CA2106952A1 - A single dose vaccination system - Google Patents
A single dose vaccination systemInfo
- Publication number
- CA2106952A1 CA2106952A1 CA002106952A CA2106952A CA2106952A1 CA 2106952 A1 CA2106952 A1 CA 2106952A1 CA 002106952 A CA002106952 A CA 002106952A CA 2106952 A CA2106952 A CA 2106952A CA 2106952 A1 CA2106952 A1 CA 2106952A1
- Authority
- CA
- Canada
- Prior art keywords
- water
- biologically active
- active material
- implantation
- excipient
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0002—Galenical forms characterised by the drug release technique; Application systems commanded by energy
- A61K9/0004—Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
Abstract
The invention provides a pharmaceutical or veterinary implant, which when parenterally administered releases a pulse of at least one biologically active material at a controllable time interval after implantation. The implant comprises the biologically active material; an excipient comprising at least one water soluble material and at least one water insoluble material; and a polymer film coating adapted to rupture at a predetermined period of time after implantation, and wherein the excipients and polymers are biocompatible.
The biologically active material is selected from the.
group consisting of antigens, antibodies, hormones, growth promotants, antibiotics, nutrients, minerals and vitamins. Preferably the excipient comprises a combination of two or more water-soluble and water-insoluble materials.
The biologically active material is selected from the.
group consisting of antigens, antibodies, hormones, growth promotants, antibiotics, nutrients, minerals and vitamins. Preferably the excipient comprises a combination of two or more water-soluble and water-insoluble materials.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AUPK526891 | 1991-03-26 | ||
AUPK5268 | 1991-03-26 | ||
PCT/AU1992/000124 WO1992017165A1 (en) | 1991-03-26 | 1992-03-25 | A single dose vaccination system |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2106952A1 true CA2106952A1 (en) | 1992-09-27 |
CA2106952C CA2106952C (en) | 2003-01-21 |
Family
ID=3775296
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002106952A Expired - Fee Related CA2106952C (en) | 1991-03-26 | 1992-03-25 | A single dose vaccination system |
Country Status (8)
Country | Link |
---|---|
US (1) | US5593697A (en) |
EP (1) | EP0576522B1 (en) |
AT (1) | ATE194910T1 (en) |
CA (1) | CA2106952C (en) |
DE (1) | DE69231291T2 (en) |
ES (1) | ES2149174T3 (en) |
NZ (2) | NZ286242A (en) |
WO (1) | WO1992017165A1 (en) |
Families Citing this family (62)
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US5358502A (en) * | 1993-02-25 | 1994-10-25 | Pfizer Inc | PH-triggered osmotic bursting delivery devices |
ES2199227T5 (en) * | 1993-03-29 | 2007-12-01 | Pfizer Inc. | MULTICOMPONENT CLOSTRIDIAL VACCINES USING SAPONINA ASSISTANTS. |
CA2183684C (en) * | 1994-02-18 | 2008-07-15 | Richard D. Hansen | Inoculation of animals with dried, pelleted biological materials |
CA2193806A1 (en) * | 1994-06-22 | 1995-12-28 | Michael Cardamone | Controlled release device and method |
FR2723536A1 (en) * | 1994-08-11 | 1996-02-16 | Seth Pawan | COMPOSITION FOR SELECTIVE RELEASE OF AN ACTIVE INGREDIENT |
AUPM897594A0 (en) * | 1994-10-25 | 1994-11-17 | Daratech Pty Ltd | Controlled release container |
US5840332A (en) * | 1996-01-18 | 1998-11-24 | Perio Products Ltd. | Gastrointestinal drug delivery system |
US6143037A (en) * | 1996-06-12 | 2000-11-07 | The Regents Of The University Of Michigan | Compositions and methods for coating medical devices |
US6140475A (en) * | 1997-04-11 | 2000-10-31 | Altus Biologics Inc. | Controlled dissolution crosslinked protein crystals |
PL203733B1 (en) * | 1997-10-09 | 2009-11-30 | Dexcel Pharma Technologies Ltd | System for delivering a drug of retarded total release within the region of gastrointestinal tract |
US6541606B2 (en) | 1997-12-31 | 2003-04-01 | Altus Biologics Inc. | Stabilized protein crystals formulations containing them and methods of making them |
CN1299272A (en) * | 1998-03-02 | 2001-06-13 | 应用疫苗技术公司 | Method and device for modulating the immune response |
US6531152B1 (en) | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
US20030099682A1 (en) * | 1998-11-20 | 2003-05-29 | Francis Moussy | Apparatus and method for control of tissue/implant interactions |
EP1130996B1 (en) | 1998-11-20 | 2005-04-13 | The University of Connecticut | Generic integrated implantable potentiostat telemetry unit for electrochemical sensors |
US6217895B1 (en) | 1999-03-22 | 2001-04-17 | Control Delivery Systems | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
US20040121014A1 (en) * | 1999-03-22 | 2004-06-24 | Control Delivery Systems, Inc. | Method for treating and/or preventing retinal diseases with sustained release corticosteroids |
US6632451B2 (en) | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
US6245913B1 (en) | 1999-06-30 | 2001-06-12 | Wockhardt Europe Limited | Synthetic procedure for 5-methoxy-2-[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methylthio]-IH-benzimidazole hydrochloride and its conversion to omeprazole |
US7030097B1 (en) | 1999-07-14 | 2006-04-18 | Cornell Research Foundation, Inc. | Controlled nucleic acid delivery systems |
US6592869B2 (en) * | 1999-08-24 | 2003-07-15 | Teva Pharmaceutical Industries, Ltd. | Vaccine composition and method of using the same |
CN100406004C (en) | 1999-08-24 | 2008-07-30 | 特瓦制药工业有限公司 | Vaccine composition and method of using same |
US6375972B1 (en) | 2000-04-26 | 2002-04-23 | Control Delivery Systems, Inc. | Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof |
DE10035156A1 (en) * | 2000-07-19 | 2002-02-07 | Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh | New protein complex containing complex protein from botulinum toxin, useful for oral delivery of therapeutic polypeptide or low molecular weight pharmaceutical |
US7575780B2 (en) * | 2000-08-07 | 2009-08-18 | Orthogen Llc | Method for manufacturing particles for use in forming a resorbable implant for stimulating bone growth |
GB0025208D0 (en) * | 2000-10-13 | 2000-11-29 | Euro Celtique Sa | Delayed release pharmaceutical formulations |
US20070281003A1 (en) | 2001-10-12 | 2007-12-06 | Fuisz Richard C | Polymer-Based Films and Drug Delivery Systems Made Therefrom |
US11207805B2 (en) | 2001-10-12 | 2021-12-28 | Aquestive Therapeutics, Inc. | Process for manufacturing a resulting pharmaceutical film |
US20190328679A1 (en) | 2001-10-12 | 2019-10-31 | Aquestive Therapeutics, Inc. | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US10285910B2 (en) | 2001-10-12 | 2019-05-14 | Aquestive Therapeutics, Inc. | Sublingual and buccal film compositions |
US7357891B2 (en) | 2001-10-12 | 2008-04-15 | Monosol Rx, Llc | Process for making an ingestible film |
US8765167B2 (en) | 2001-10-12 | 2014-07-01 | Monosol Rx, Llc | Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions |
US20110033542A1 (en) | 2009-08-07 | 2011-02-10 | Monosol Rx, Llc | Sublingual and buccal film compositions |
US8603514B2 (en) | 2002-04-11 | 2013-12-10 | Monosol Rx, Llc | Uniform films for rapid dissolve dosage form incorporating taste-masking compositions |
US8900497B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for making a film having a substantially uniform distribution of components |
US8900498B2 (en) | 2001-10-12 | 2014-12-02 | Monosol Rx, Llc | Process for manufacturing a resulting multi-layer pharmaceutical film |
AU2003232078A1 (en) | 2002-05-06 | 2003-11-17 | Massachusetts Institute Of Technology | Diffusion-controlled dosage form and method of fabrication including three dimensional printing |
US8871241B2 (en) * | 2002-05-07 | 2014-10-28 | Psivida Us, Inc. | Injectable sustained release delivery devices |
US20050152939A1 (en) * | 2002-05-22 | 2005-07-14 | Bunt Craig R. | Delivery technology |
AU2003231878A1 (en) * | 2002-05-31 | 2003-12-19 | Solux Corporation | Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use |
KR100628263B1 (en) * | 2002-08-21 | 2006-09-27 | 엘지.필립스 엘시디 주식회사 | Liquid crystal display device |
US7452350B2 (en) * | 2003-07-09 | 2008-11-18 | Yeakley Rourke M | Pre-dosed oral liquid medication dispensing system |
CA2536622C (en) * | 2003-08-29 | 2014-02-11 | The Brigham And Women's Hospital, Inc. | Inhibitors of cellular necrosis |
US20060280795A1 (en) * | 2005-06-08 | 2006-12-14 | Dexcel Pharma Technologies, Ltd. | Specific time-delayed burst profile delivery system |
WO2007025191A1 (en) | 2005-08-23 | 2007-03-01 | Smith & Nephew, Inc. | Telemetric orthopaedic implant |
CN101370477A (en) * | 2006-01-20 | 2009-02-18 | 莫诺索尔克斯有限公司 | Film lined pouch and method of manufacturing this pouch |
US9849216B2 (en) * | 2006-03-03 | 2017-12-26 | Smith & Nephew, Inc. | Systems and methods for delivering a medicament |
US20080081071A1 (en) * | 2006-09-29 | 2008-04-03 | Pradeep Sanghvi | Film Embedded Packaging and Method of Making Same |
WO2010075561A1 (en) | 2008-12-23 | 2010-07-01 | President And Fellows Of Harvard College | Small molecule inhibitors of necroptosis |
US20110238036A1 (en) * | 2009-12-23 | 2011-09-29 | Psivida Us, Inc. | Sustained release delivery devices |
US8109917B2 (en) * | 2010-01-18 | 2012-02-07 | Rourke M. Yeakley | Twistable medication dispensing system |
US8206368B2 (en) * | 2010-01-18 | 2012-06-26 | Rourke M. Yeakley | Multi-chamber mixture dispensing system |
US9149959B2 (en) | 2010-10-22 | 2015-10-06 | Monosol Rx, Llc | Manufacturing of small film strips |
ES2675307T3 (en) | 2011-12-22 | 2018-07-10 | Centre Hospitalier Universitaire Vaudois (Chuv) | Selective plasma activation for medical implants and wound healing devices |
CN104136004B (en) | 2012-02-22 | 2018-03-06 | 达切斯内公司 | Doxylamine and pyridoxol and/or the preparation of its metabolin or salt |
US9717583B2 (en) | 2014-03-13 | 2017-08-01 | Cell and Molecular Tissue Engineering, LLC | Sensors, cannulas, collars and coated surgical mesh, and corresponding systems and methods |
US9725452B2 (en) | 2013-03-15 | 2017-08-08 | Presidents And Fellows Of Harvard College | Substituted indoles and pyrroles as RIP kinase inhibitors |
JP6395800B2 (en) * | 2013-03-15 | 2018-09-26 | インキューブ ラブズ, エルエルシー | Multi-stage biodegradable drug delivery platform |
KR102242391B1 (en) | 2013-07-22 | 2021-04-21 | 듀체스나이 아이엔씨 | Composition for the management of nausea and vomiting |
AR102981A1 (en) | 2014-12-11 | 2017-04-05 | Harvard College | INHIBITORS OF CELL NECROSIS AND METHODS OF PREPARATION OF THE SAME |
CN109310646A (en) | 2016-05-05 | 2019-02-05 | 阿奎斯蒂弗医疗股份有限公司 | Enhance the adrenaline composition of delivering |
US11273131B2 (en) | 2016-05-05 | 2022-03-15 | Aquestive Therapeutics, Inc. | Pharmaceutical compositions with enhanced permeation |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3247066A (en) * | 1962-09-12 | 1966-04-19 | Parke Davis & Co | Controlled release dosage form containing water-swellable beadlet |
FR2454804B1 (en) * | 1979-04-26 | 1986-11-21 | Sanofi Sa | DIHYDROERGOTOXIN-BASED MEDICINAL PRODUCT AND PROCESS FOR PREPARING THE SAME |
ZA86252B (en) * | 1985-01-30 | 1986-09-24 | Warner Lambert Co | Coated dosage forms |
DE3678641D1 (en) * | 1985-08-16 | 1991-05-16 | Procter & Gamble | PARTICLES WITH CONSTANT RELEASE OF ACTIVE SUBSTANCES. |
JPH0778017B2 (en) * | 1985-12-28 | 1995-08-23 | 住友製薬株式会社 | Pulsed and sustained release formulation |
EP0270575A4 (en) * | 1986-05-16 | 1988-10-20 | Victoria State | Biocompatible implants. |
JPH04504122A (en) * | 1989-03-17 | 1992-07-23 | ピットマン―ムーア・インコーポレイテッド | Controlled release devices for macromolecular proteins |
US5026559A (en) * | 1989-04-03 | 1991-06-25 | Kinaform Technology, Inc. | Sustained-release pharmaceutical preparation |
EP0408496A3 (en) * | 1989-07-12 | 1992-07-01 | Ciba-Geigy Ag | Solid dosage form for pharmaceutical substances |
JPH03197421A (en) * | 1989-12-26 | 1991-08-28 | Takeda Chem Ind Ltd | Sustainingly releasable tablet |
US5091185A (en) * | 1990-06-20 | 1992-02-25 | Monsanto Company | Coated veterinary implants |
-
1992
- 1992-03-19 NZ NZ286242A patent/NZ286242A/en unknown
- 1992-03-19 NZ NZ242065A patent/NZ242065A/en unknown
- 1992-03-25 US US08/119,174 patent/US5593697A/en not_active Expired - Fee Related
- 1992-03-25 ES ES92907229T patent/ES2149174T3/en not_active Expired - Lifetime
- 1992-03-25 CA CA002106952A patent/CA2106952C/en not_active Expired - Fee Related
- 1992-03-25 AT AT92907229T patent/ATE194910T1/en not_active IP Right Cessation
- 1992-03-25 DE DE69231291T patent/DE69231291T2/en not_active Expired - Fee Related
- 1992-03-25 WO PCT/AU1992/000124 patent/WO1992017165A1/en active IP Right Grant
- 1992-03-25 EP EP92907229A patent/EP0576522B1/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
EP0576522B1 (en) | 2000-07-26 |
ATE194910T1 (en) | 2000-08-15 |
ES2149174T3 (en) | 2000-11-01 |
WO1992017165A1 (en) | 1992-10-15 |
DE69231291D1 (en) | 2000-08-31 |
US5593697A (en) | 1997-01-14 |
EP0576522A1 (en) | 1994-01-05 |
CA2106952C (en) | 2003-01-21 |
NZ242065A (en) | 1996-06-25 |
NZ286242A (en) | 1997-11-24 |
EP0576522A4 (en) | 1994-06-01 |
DE69231291T2 (en) | 2001-01-18 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
EEER | Examination request | ||
MKLA | Lapsed |