CA2106952A1 - A single dose vaccination system - Google Patents

A single dose vaccination system

Info

Publication number
CA2106952A1
CA2106952A1 CA002106952A CA2106952A CA2106952A1 CA 2106952 A1 CA2106952 A1 CA 2106952A1 CA 002106952 A CA002106952 A CA 002106952A CA 2106952 A CA2106952 A CA 2106952A CA 2106952 A1 CA2106952 A1 CA 2106952A1
Authority
CA
Canada
Prior art keywords
water
biologically active
active material
implantation
excipient
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002106952A
Other languages
French (fr)
Other versions
CA2106952C (en
Inventor
Ian George Barr
William James Thiel
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CSL Ltd
Monash University
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2106952A1 publication Critical patent/CA2106952A1/en
Application granted granted Critical
Publication of CA2106952C publication Critical patent/CA2106952C/en
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0002Galenical forms characterised by the drug release technique; Application systems commanded by energy
    • A61K9/0004Osmotic delivery systems; Sustained release driven by osmosis, thermal energy or gas
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5031Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A61K9/5047Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings

Abstract

The invention provides a pharmaceutical or veterinary implant, which when parenterally administered releases a pulse of at least one biologically active material at a controllable time interval after implantation. The implant comprises the biologically active material; an excipient comprising at least one water soluble material and at least one water insoluble material; and a polymer film coating adapted to rupture at a predetermined period of time after implantation, and wherein the excipients and polymers are biocompatible.
The biologically active material is selected from the.
group consisting of antigens, antibodies, hormones, growth promotants, antibiotics, nutrients, minerals and vitamins. Preferably the excipient comprises a combination of two or more water-soluble and water-insoluble materials.
CA002106952A 1991-03-26 1992-03-25 A single dose vaccination system Expired - Fee Related CA2106952C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
AUPK526891 1991-03-26
AUPK5268 1991-03-26
PCT/AU1992/000124 WO1992017165A1 (en) 1991-03-26 1992-03-25 A single dose vaccination system

Publications (2)

Publication Number Publication Date
CA2106952A1 true CA2106952A1 (en) 1992-09-27
CA2106952C CA2106952C (en) 2003-01-21

Family

ID=3775296

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002106952A Expired - Fee Related CA2106952C (en) 1991-03-26 1992-03-25 A single dose vaccination system

Country Status (8)

Country Link
US (1) US5593697A (en)
EP (1) EP0576522B1 (en)
AT (1) ATE194910T1 (en)
CA (1) CA2106952C (en)
DE (1) DE69231291T2 (en)
ES (1) ES2149174T3 (en)
NZ (2) NZ286242A (en)
WO (1) WO1992017165A1 (en)

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US6541606B2 (en) 1997-12-31 2003-04-01 Altus Biologics Inc. Stabilized protein crystals formulations containing them and methods of making them
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US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
US20030099682A1 (en) * 1998-11-20 2003-05-29 Francis Moussy Apparatus and method for control of tissue/implant interactions
EP1130996B1 (en) 1998-11-20 2005-04-13 The University of Connecticut Generic integrated implantable potentiostat telemetry unit for electrochemical sensors
US6217895B1 (en) 1999-03-22 2001-04-17 Control Delivery Systems Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US20040121014A1 (en) * 1999-03-22 2004-06-24 Control Delivery Systems, Inc. Method for treating and/or preventing retinal diseases with sustained release corticosteroids
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
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US7030097B1 (en) 1999-07-14 2006-04-18 Cornell Research Foundation, Inc. Controlled nucleic acid delivery systems
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CN100406004C (en) 1999-08-24 2008-07-30 特瓦制药工业有限公司 Vaccine composition and method of using same
US6375972B1 (en) 2000-04-26 2002-04-23 Control Delivery Systems, Inc. Sustained release drug delivery devices, methods of use, and methods of manufacturing thereof
DE10035156A1 (en) * 2000-07-19 2002-02-07 Biotecon Ges Fuer Biotechnologische Entwicklung & Consulting Mbh New protein complex containing complex protein from botulinum toxin, useful for oral delivery of therapeutic polypeptide or low molecular weight pharmaceutical
US7575780B2 (en) * 2000-08-07 2009-08-18 Orthogen Llc Method for manufacturing particles for use in forming a resorbable implant for stimulating bone growth
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US20190328679A1 (en) 2001-10-12 2019-10-31 Aquestive Therapeutics, Inc. Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US10285910B2 (en) 2001-10-12 2019-05-14 Aquestive Therapeutics, Inc. Sublingual and buccal film compositions
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US8765167B2 (en) 2001-10-12 2014-07-01 Monosol Rx, Llc Uniform films for rapid-dissolve dosage form incorporating anti-tacking compositions
US20110033542A1 (en) 2009-08-07 2011-02-10 Monosol Rx, Llc Sublingual and buccal film compositions
US8603514B2 (en) 2002-04-11 2013-12-10 Monosol Rx, Llc Uniform films for rapid dissolve dosage form incorporating taste-masking compositions
US8900497B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for making a film having a substantially uniform distribution of components
US8900498B2 (en) 2001-10-12 2014-12-02 Monosol Rx, Llc Process for manufacturing a resulting multi-layer pharmaceutical film
AU2003232078A1 (en) 2002-05-06 2003-11-17 Massachusetts Institute Of Technology Diffusion-controlled dosage form and method of fabrication including three dimensional printing
US8871241B2 (en) * 2002-05-07 2014-10-28 Psivida Us, Inc. Injectable sustained release delivery devices
US20050152939A1 (en) * 2002-05-22 2005-07-14 Bunt Craig R. Delivery technology
AU2003231878A1 (en) * 2002-05-31 2003-12-19 Solux Corporation Pharmaceutical preparation of botulinum neurotoxin, methods of synthesis and methods of clinical use
KR100628263B1 (en) * 2002-08-21 2006-09-27 엘지.필립스 엘시디 주식회사 Liquid crystal display device
US7452350B2 (en) * 2003-07-09 2008-11-18 Yeakley Rourke M Pre-dosed oral liquid medication dispensing system
CA2536622C (en) * 2003-08-29 2014-02-11 The Brigham And Women's Hospital, Inc. Inhibitors of cellular necrosis
US20060280795A1 (en) * 2005-06-08 2006-12-14 Dexcel Pharma Technologies, Ltd. Specific time-delayed burst profile delivery system
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CN101370477A (en) * 2006-01-20 2009-02-18 莫诺索尔克斯有限公司 Film lined pouch and method of manufacturing this pouch
US9849216B2 (en) * 2006-03-03 2017-12-26 Smith & Nephew, Inc. Systems and methods for delivering a medicament
US20080081071A1 (en) * 2006-09-29 2008-04-03 Pradeep Sanghvi Film Embedded Packaging and Method of Making Same
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US8109917B2 (en) * 2010-01-18 2012-02-07 Rourke M. Yeakley Twistable medication dispensing system
US8206368B2 (en) * 2010-01-18 2012-06-26 Rourke M. Yeakley Multi-chamber mixture dispensing system
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Also Published As

Publication number Publication date
EP0576522B1 (en) 2000-07-26
ATE194910T1 (en) 2000-08-15
ES2149174T3 (en) 2000-11-01
WO1992017165A1 (en) 1992-10-15
DE69231291D1 (en) 2000-08-31
US5593697A (en) 1997-01-14
EP0576522A1 (en) 1994-01-05
CA2106952C (en) 2003-01-21
NZ242065A (en) 1996-06-25
NZ286242A (en) 1997-11-24
EP0576522A4 (en) 1994-06-01
DE69231291T2 (en) 2001-01-18

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