CA2323680A1 - Orally disintegrable tablets - Google Patents
Orally disintegrable tablets Download PDFInfo
- Publication number
- CA2323680A1 CA2323680A1 CA002323680A CA2323680A CA2323680A1 CA 2323680 A1 CA2323680 A1 CA 2323680A1 CA 002323680 A CA002323680 A CA 002323680A CA 2323680 A CA2323680 A CA 2323680A CA 2323680 A1 CA2323680 A1 CA 2323680A1
- Authority
- CA
- Canada
- Prior art keywords
- administered
- orally disintegrable
- fine granules
- average particle
- particle diameter
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
- A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
- A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Abstract
An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 µm or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CA002587022A CA2587022A1 (en) | 1998-05-18 | 1999-05-17 | Orally disintegrable tablets |
Applications Claiming Priority (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP10/135472 | 1998-05-18 | ||
JP13547298 | 1998-05-18 | ||
JP21926698 | 1998-08-03 | ||
JP10/219266 | 1998-08-03 | ||
JP10/222151 | 1998-08-05 | ||
JP22215198 | 1998-08-05 | ||
JP514499 | 1999-01-12 | ||
JP11/5144 | 1999-01-12 | ||
JP11/15851 | 1999-01-25 | ||
JP1585199 | 1999-01-25 | ||
PCT/JP1999/002548 WO1999059544A2 (en) | 1998-05-18 | 1999-05-17 | Orally disintegrable tablets |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002587022A Division CA2587022A1 (en) | 1998-05-18 | 1999-05-17 | Orally disintegrable tablets |
Publications (2)
Publication Number | Publication Date |
---|---|
CA2323680A1 true CA2323680A1 (en) | 1999-11-25 |
CA2323680C CA2323680C (en) | 2007-05-22 |
Family
ID=27518561
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002323680A Expired - Lifetime CA2323680C (en) | 1998-05-18 | 1999-05-17 | Orally disintegrable tablets |
CA002587022A Abandoned CA2587022A1 (en) | 1998-05-18 | 1999-05-17 | Orally disintegrable tablets |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CA002587022A Abandoned CA2587022A1 (en) | 1998-05-18 | 1999-05-17 | Orally disintegrable tablets |
Country Status (16)
Country | Link |
---|---|
US (5) | US6328994B1 (en) |
EP (3) | EP1121103B1 (en) |
JP (2) | JP3746167B2 (en) |
KR (2) | KR101032289B1 (en) |
CN (1) | CN1195500C (en) |
AT (1) | ATE348601T1 (en) |
AU (1) | AU3731699A (en) |
CA (2) | CA2323680C (en) |
CY (2) | CY1105908T1 (en) |
DE (1) | DE69934505T2 (en) |
DK (3) | DK1121103T3 (en) |
ES (2) | ES2274625T3 (en) |
HK (2) | HK1096021A1 (en) |
PT (3) | PT1736144E (en) |
TW (1) | TWI243062B (en) |
WO (1) | WO1999059544A2 (en) |
Families Citing this family (216)
Publication number | Priority date | Publication date | Assignee | Title |
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US8071128B2 (en) | 1996-06-14 | 2011-12-06 | Kyowa Hakko Kirin Co., Ltd. | Intrabuccally rapidly disintegrating tablet and a production method of the tablets |
ATE348601T1 (en) * | 1998-05-18 | 2007-01-15 | Takeda Pharmaceutical | ORACULATE TABLET CONTAINING A BENZIMIDAZOLE |
ES2347968T3 (en) * | 1998-07-28 | 2010-11-26 | Takeda Pharmaceutical Company Limited | SOLID PREPARATION THAT DISAPPEARS RAPIDLY. |
EP1203580A4 (en) * | 1999-06-18 | 2004-06-30 | Takeda Chemical Industries Ltd | Quickly disintegrating solid preparations |
JP2001058944A (en) * | 1999-06-18 | 2001-03-06 | Takeda Chem Ind Ltd | Rapidly disintegrating solid formulation |
US20030180352A1 (en) * | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
US20060034937A1 (en) * | 1999-11-23 | 2006-02-16 | Mahesh Patel | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
WO2001064189A1 (en) * | 2000-03-02 | 2001-09-07 | Basf Aktiengesellschaft | Coated granules and foaming compositions containing the same |
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US20020192299A1 (en) * | 2000-12-28 | 2002-12-19 | Rajneesh Taneja | Pharmaceutical compositions of a non-enteric coated proton pump inhibitor with a carbonate salt and bicarbonate salt combination |
ATE452637T1 (en) | 2001-01-29 | 2010-01-15 | Shionogi & Co | MEDICINAL PREPARATION CONTAINING 5-METHYL-1-PHENYL-2-(1H)-PYRIDONE AS AN ACTIVE INGREDIENT |
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1999
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- 1999-05-17 PT PT60766342T patent/PT1736144E/en unknown
- 1999-05-17 EP EP99919614A patent/EP1121103B1/en not_active Revoked
- 1999-05-17 US US09/355,781 patent/US6328994B1/en not_active Expired - Lifetime
- 1999-05-17 EP EP10177471.9A patent/EP2263660B1/en not_active Expired - Lifetime
- 1999-05-17 DK DK99919614T patent/DK1121103T3/en active
- 1999-05-17 ES ES99919614T patent/ES2274625T3/en not_active Expired - Lifetime
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- 1999-05-17 WO PCT/JP1999/002548 patent/WO1999059544A2/en active IP Right Grant
- 1999-05-17 PT PT99919614T patent/PT1121103E/en unknown
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- 1999-05-17 KR KR1020047021546A patent/KR101032289B1/en not_active IP Right Cessation
- 1999-05-17 DK DK06076634.2T patent/DK1736144T3/en active
- 1999-05-17 EP EP06076634.2A patent/EP1736144B1/en not_active Expired - Lifetime
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- 1999-05-17 JP JP13517799A patent/JP3746167B2/en not_active Expired - Fee Related
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2001
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