DE3463211D1 - Biodegradable polypeptide and its use in the sustained release of medicaments - Google Patents
Biodegradable polypeptide and its use in the sustained release of medicamentsInfo
- Publication number
- DE3463211D1 DE3463211D1 DE8484810156T DE3463211T DE3463211D1 DE 3463211 D1 DE3463211 D1 DE 3463211D1 DE 8484810156 T DE8484810156 T DE 8484810156T DE 3463211 T DE3463211 T DE 3463211T DE 3463211 D1 DE3463211 D1 DE 3463211D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- medicaments
- sustained release
- sec
- biodegradable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
- A61K9/7007—Drug-containing films, membranes or sheets
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/14—Macromolecular materials
- A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
- A61L27/227—Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G69/00—Macromolecular compounds obtained by reactions forming a carboxylic amide link in the main chain of the macromolecule
- C08G69/02—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids
- C08G69/08—Polyamides derived from amino-carboxylic acids or from polyamines and polycarboxylic acids derived from amino-carboxylic acids
- C08G69/10—Alpha-amino-carboxylic acids
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G73/00—Macromolecular compounds obtained by reactions forming a linkage containing nitrogen with or without oxygen or carbon in the main chain of the macromolecule, not provided for in groups C08G12/00 - C08G71/00
- C08G73/06—Polycondensates having nitrogen-containing heterocyclic rings in the main chain of the macromolecule
- C08G73/10—Polyimides; Polyester-imides; Polyamide-imides; Polyamide acids or similar polyimide precursors
- C08G73/1092—Polysuccinimides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/60—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a special physical form
- A61L2300/602—Type of release, e.g. controlled, sustained, slow
- A61L2300/604—Biodegradation
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S930/00—Peptide or protein sequence
- Y10S930/01—Peptide or protein sequence
- Y10S930/29—Polyamino acid or polypeptide with an uninterrupted series of peptide repeating units
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
CH361983 | 1983-07-01 |
Publications (1)
Publication Number | Publication Date |
---|---|
DE3463211D1 true DE3463211D1 (en) | 1987-05-21 |
Family
ID=4259870
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE8484810156T Expired DE3463211D1 (en) | 1983-07-01 | 1984-04-02 | Biodegradable polypeptide and its use in the sustained release of medicaments |
Country Status (11)
Country | Link |
---|---|
US (1) | US4675381A (de) |
EP (2) | EP0150184A1 (de) |
JP (1) | JPS60501759A (de) |
AT (1) | ATE26584T1 (de) |
AU (1) | AU2698684A (de) |
CA (1) | CA1241322A (de) |
DE (1) | DE3463211D1 (de) |
DK (1) | DK88385A (de) |
FI (1) | FI73448C (de) |
NO (1) | NO850771L (de) |
WO (1) | WO1985000372A1 (de) |
Families Citing this family (64)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5288498A (en) * | 1985-05-01 | 1994-02-22 | University Of Utah Research Foundation | Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments |
JPS60237015A (ja) * | 1984-05-11 | 1985-11-25 | Koken:Kk | 医薬徐放剤 |
US4880635B1 (en) * | 1984-08-08 | 1996-07-02 | Liposome Company | Dehydrated liposomes |
ATE60340T1 (de) * | 1984-10-19 | 1991-02-15 | Battelle Memorial Institute | Durch mikroorganismen abbaubares polypeptid und seine verwendung fuer die fortschreitende abgabe von medikamenten. |
US4863735A (en) * | 1985-02-19 | 1989-09-05 | Massachusetts Institute Of Technology | Biodegradable polymeric drug delivery system with adjuvant activity |
CS252559B1 (en) * | 1985-03-22 | 1987-09-17 | Frantisek Rypacek | Polymer stabilizer of emulsion type water in oil |
US4895724A (en) * | 1985-06-07 | 1990-01-23 | Pfizer Inc. | Chitosan compositions for controlled and prolonged release of macromolecules |
CH667874A5 (fr) * | 1985-12-19 | 1988-11-15 | Battelle Memorial Institute | Polypeptide synthetique biodegradable et son utilisation pour la preparation de medicaments. |
IL78826A (en) * | 1986-05-19 | 1991-05-12 | Yissum Res Dev Co | Precursor composition for the preparation of a biodegradable implant for the sustained release of an active material and such implants prepared therefrom |
CA1257199A (en) * | 1986-05-20 | 1989-07-11 | Paul Y. Wang | Preparation containing bioactive macromolecular substance for multi-months release in vivo |
DE3700128A1 (de) * | 1987-01-03 | 1988-07-14 | Hoechst Ag | Biologisch abbaubare poly- (hydroxyalkyl)- aminodicarbonsaeure-derivate, verfahren zu ihrer herstellung und verwendung derselben fuer depotzubereitungen mit kontrollierter wirkstoffabgabe |
US4916204A (en) * | 1987-07-31 | 1990-04-10 | Massachusetts Institute Of Technology | Pure polyanhydride from dicarboxylic acid and coupling agent |
US5681543A (en) * | 1988-02-29 | 1997-10-28 | Shering Aktiengesellschaft | Polymer-bonded complexing agents and pharmaceutical agents containing them for MRI |
GB8805286D0 (en) * | 1988-03-05 | 1988-04-07 | Schering Agrochemicals Ltd | Trypanocides |
US5023080A (en) * | 1988-06-17 | 1991-06-11 | Basic Bio Systems, Inc. | Time release protein |
US5700479A (en) * | 1988-12-23 | 1997-12-23 | Guidor Ab | Surgical element and method for selective tissue regeneration |
US4990336A (en) * | 1989-02-08 | 1991-02-05 | Biosearch, Inc. | Sustained release dosage form |
US5126147A (en) * | 1990-02-08 | 1992-06-30 | Biosearch, Inc. | Sustained release dosage form |
GB9107628D0 (en) | 1991-04-10 | 1991-05-29 | Moonbrook Limited | Preparation of diagnostic agents |
US5993805A (en) | 1991-04-10 | 1999-11-30 | Quadrant Healthcare (Uk) Limited | Spray-dried microparticles and their use as therapeutic vehicles |
GB9204918D0 (en) * | 1992-03-06 | 1992-04-22 | Nycomed As | Chemical compounds |
ES2161747T3 (es) * | 1993-11-24 | 2001-12-16 | Rhodia Chimie Sa | Procedimiento de preparacion de poliimidas o de sus hidrolizados polipeptidicos biodegradables. |
FR2712892B1 (fr) * | 1993-11-24 | 1995-12-22 | Rhone Poulenc Chimie | Procédé de préparation de polyimides ou de leurs hydrolysats biodégradables. |
US5904935A (en) * | 1995-06-07 | 1999-05-18 | Alza Corporation | Peptide/protein suspending formulations |
DE19545678A1 (de) * | 1995-12-07 | 1997-06-12 | Goldschmidt Ag Th | Copolymere Polyaminosäureester |
US6231888B1 (en) | 1996-01-18 | 2001-05-15 | Perio Products Ltd. | Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps |
US6441025B2 (en) * | 1996-03-12 | 2002-08-27 | Pg-Txl Company, L.P. | Water soluble paclitaxel derivatives |
AU5546698A (en) * | 1997-01-13 | 1998-08-03 | Universite Laval | Membrane-permeable derivatives converted intracellularly into active peptides |
US6517869B1 (en) | 1997-12-12 | 2003-02-11 | Expression Genetics, Inc. | Positively charged poly(alpha-(omega-aminoalkyl)lycolic acid) for the delivery of a bioactive agent via tissue and cellular uptake |
DE19822600C2 (de) * | 1998-05-20 | 2003-08-21 | Goldschmidt Ag Th | Copolymere, hydrophob modifizierte Polyasparaginsäureester mit erhöhter Molekularmasse |
DE19822599C2 (de) * | 1998-05-20 | 2003-02-06 | Goldschmidt Ag Th | Copolymere hydrophob modifizierte Polyasparaginsäureesteramide und ihre Verwendung |
US6531152B1 (en) | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
US6632451B2 (en) | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
JP4987205B2 (ja) * | 2000-03-03 | 2012-07-25 | ジェネトロニクス, インコーポレイテッド | 遺伝子送達用核酸製剤および使用方法 |
EP2286843A3 (de) | 2000-06-02 | 2011-08-03 | Bracco Suisse SA | Arzneimitteln zur Zielgerichtung von Endothelzellen |
DE60223239T2 (de) * | 2001-04-06 | 2008-08-14 | Bracco Research S.A. | Vorrichtung zur Messung lokaler physikalischer Parameter in einem flüssigkeitsgefüllten Hohlraum |
AUPR610501A0 (en) * | 2001-07-04 | 2001-07-26 | Smart Drug Systems Inc | Treatment of parasitic disease |
US20030109432A1 (en) * | 2001-12-10 | 2003-06-12 | Zuo William W. | Anticancer polypeptide-metal complexes and compositions, methods of making, and methods of using same |
ES2377318T3 (es) | 2002-09-06 | 2012-03-26 | Cerulean Pharma Inc. | Polímeros a base de ciclodextrina para el suministro de los agentes terapéuticos enlazados covalentemente a ellos |
EP1590006B1 (de) * | 2003-02-04 | 2010-09-08 | Bracco Suisse SA | Ultraschall kontrastmittel und verfahren zur erstellung |
US20070128117A1 (en) * | 2003-02-04 | 2007-06-07 | Bracco International B.V. | Ultrasound contrast agents and process for the preparation thereof |
CA2547024C (en) | 2003-12-22 | 2013-12-17 | Bracco Research Sa | Gas-filled microvesicle assembly for contrast imaging |
US20060067972A1 (en) * | 2004-06-23 | 2006-03-30 | Flowmedica, Inc. | Devices for renal-based heart failure treatment |
JP4837663B2 (ja) * | 2004-08-18 | 2011-12-14 | ブラッコ・シュイス・ソシエテ・アノニム | 造影画像化のためのガス充填微小胞組成物 |
EP1714642A1 (de) | 2005-04-18 | 2006-10-25 | Bracco Research S.A. | Pharmazeutische Formulierung mit gasgefüllten Mikrokapseln zur ultraschallgesteuerten Freisetzung |
KR20080068048A (ko) | 2005-10-28 | 2008-07-22 | 메이지 세이카 가부시키가이샤 | 녹농균의 외막 단백질 pa5158 |
JP5237821B2 (ja) * | 2005-12-05 | 2013-07-17 | 日東電工株式会社 | ポリグルタミン酸−アミノ酸結合体および方法 |
CN101454446A (zh) | 2006-03-30 | 2009-06-10 | 明治制果株式会社 | 绿脓杆菌的外膜蛋白pa0427 |
JP2010516625A (ja) | 2007-01-24 | 2010-05-20 | インサート セラピューティクス, インコーポレイテッド | 制御された薬物送達のためのテザー基を有するポリマー−薬物コンジュゲート |
US20080181852A1 (en) * | 2007-01-29 | 2008-07-31 | Nitto Denko Corporation | Multi-functional Drug Carriers |
WO2008124735A2 (en) * | 2007-04-10 | 2008-10-16 | Nitto Denko Corporation | Multi-functional polyglutamate drug carriers |
JP2010528122A (ja) * | 2007-05-09 | 2010-08-19 | 日東電工株式会社 | 白金薬剤と結合されたポリマー |
WO2008141110A2 (en) * | 2007-05-09 | 2008-11-20 | Nitto Denko Corporation | Polyglutamate conjugates and polyglutamate-amino acid conjugates having a plurality of drugs |
PT2155255E (pt) | 2007-05-09 | 2013-10-15 | Nitto Denko Corp | Composições que incluem um composto hidrofóbico e um conjugado de poliaminoácido |
WO2009005040A1 (ja) * | 2007-06-29 | 2009-01-08 | Meiji Seika Kaisha Ltd. | 緑膿菌の外膜タンパク質pa4710 |
EP2236515A4 (de) | 2007-12-25 | 2012-10-31 | Meiji Seika Kaisha | Komponentenprotein pa1698 für das typ-iii-sekretionssystem von pseudomonas aeruginosa |
JP2011513412A (ja) * | 2008-03-06 | 2011-04-28 | 日東電工株式会社 | ポリマーパクリタキセル結合体を含む癌を治療するための薬学組成物 |
MX2012003078A (es) * | 2009-09-15 | 2012-08-03 | Alomone Preclinical Ltd | Nuevos peptidos aislados de veneno de araña y sus usos. |
AU2010321533A1 (en) * | 2009-11-23 | 2012-05-31 | Cerulean Pharma Inc. | Cyclodextrin-based polymers for therapeutic delivery |
US20110237686A1 (en) | 2010-03-26 | 2011-09-29 | Cerulean Pharma Inc | Formulations and methods of use |
EP2686010A2 (de) | 2011-03-16 | 2014-01-22 | Regents of the University of Minnesota | Zusammensetzungen und verfahren zur induktion von immunreaktionen gegen bakterien des genus staphylococcus |
US20150147328A1 (en) | 2012-05-07 | 2015-05-28 | Mogam Biotechnology Institute | Vaccine composition for preventing staphyllococcus aureus infection |
WO2014055493A1 (en) | 2012-10-02 | 2014-04-10 | Cerulean Pharma Inc. | Methods and systems for polymer precipitation and generation of particles |
JP2021521270A (ja) | 2018-04-06 | 2021-08-26 | アンマ セラピューティクス インコーポレイテッドAmma Therapeutics, Inc. | 治療剤の制御放出用組成物 |
Family Cites Families (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3230274A (en) * | 1960-12-30 | 1966-01-18 | Merck & Co Inc | Preparation of linear polypeptides |
US3371069A (en) * | 1963-03-20 | 1968-02-27 | Ajinomoto Kk | Filaments and surgical sutures of polyl-glutamic acid partly esterified with lower alkanols and process therefor |
JPS5031905B1 (de) * | 1971-07-05 | 1975-10-16 | ||
CA1045977A (en) * | 1973-05-17 | 1979-01-09 | Arthur D. Little | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
US4351337A (en) * | 1973-05-17 | 1982-09-28 | Arthur D. Little, Inc. | Biodegradable, implantable drug delivery device, and process for preparing and using the same |
US4356166A (en) * | 1978-12-08 | 1982-10-26 | University Of Utah | Time-release chemical delivery system |
-
1984
- 1984-04-02 EP EP84901314A patent/EP0150184A1/de active Pending
- 1984-04-02 AU AU26986/84A patent/AU2698684A/en not_active Abandoned
- 1984-04-02 JP JP84501341A patent/JPS60501759A/ja active Pending
- 1984-04-02 DE DE8484810156T patent/DE3463211D1/de not_active Expired
- 1984-04-02 US US06/711,469 patent/US4675381A/en not_active Expired - Fee Related
- 1984-04-02 AT AT84810156T patent/ATE26584T1/de active
- 1984-04-02 WO PCT/CH1984/000052 patent/WO1985000372A1/fr active IP Right Grant
- 1984-04-02 EP EP84810156A patent/EP0130935B1/de not_active Expired
- 1984-06-26 CA CA000457454A patent/CA1241322A/fr not_active Expired
-
1985
- 1985-02-26 NO NO850771A patent/NO850771L/no unknown
- 1985-02-27 DK DK88385A patent/DK88385A/da not_active Application Discontinuation
- 1985-02-28 FI FI850835A patent/FI73448C/fi not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
DK88385D0 (da) | 1985-02-27 |
CA1241322A (fr) | 1988-08-30 |
FI850835A0 (fi) | 1985-02-28 |
DK88385A (da) | 1985-02-27 |
NO850771L (no) | 1985-02-26 |
EP0150184A1 (de) | 1985-08-07 |
FI73448C (fi) | 1987-10-09 |
US4675381A (en) | 1987-06-23 |
WO1985000372A1 (fr) | 1985-01-31 |
AU2698684A (en) | 1985-02-07 |
ATE26584T1 (de) | 1987-05-15 |
EP0130935A1 (de) | 1985-01-09 |
EP0130935B1 (de) | 1987-04-15 |
JPS60501759A (ja) | 1985-10-17 |
FI850835L (fi) | 1985-02-28 |
FI73448B (fi) | 1987-06-30 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE3463211D1 (en) | Biodegradable polypeptide and its use in the sustained release of medicaments | |
EP0179023A3 (en) | With micro-organisms degradable polypeptide, and its use for the progressive release of medicaments | |
GR3025333T3 (en) | Cross-linking agent | |
ES8200127A1 (es) | Un procedimiento para la preparacion de copoliesteres formadores de fibras. | |
NO931635L (no) | Fremgangsmaate for fremstilling av kinazolin-derivater | |
MX9304975A (es) | Una composicion en polvo para inhalacion y procedimiento para preparar la misma. | |
MY109310A (en) | Antimicrobial method and formulation employing type ii endoglucosidase and antimicrobial agent | |
TR199902994T2 (xx) | K�r�k veya hastal�kl� kemi�in tadavisinde geni�leyebilir cisimler kullanan sistemler. | |
EP0737700A3 (de) | Blockcopolymer enthaltendes Trennmittel, Diaminvorläufer und Verfahren zu ihrer Herstellung und daraus hergestellte Produkte die das Trennmittel enthalten | |
DE69407404D1 (de) | Feste zubereitung mit hoher freisetzung, ihre herstellung und verwendung | |
ES2012561A6 (es) | Metodo de fabricar un vehiculo de farmacos en forma de particulas de una emulsion de grasa. | |
IE801178L (en) | 4-substituted-3-hydroxy-3-pyrroline-2,5-diones. | |
MY105493A (en) | Contrast media | |
GR3029791T3 (en) | Improved immunogenic compositions against human gastrin 17 | |
IL115138A0 (en) | Implantable polymer-containing molded articles for the administration of active substances to plants and processes for the preparation thereof | |
PL268927A1 (en) | Method of obtaining novel derivatives of benzimidazole | |
ZA884622B (en) | Pharmaceutical compositions in the form of pellets with enzymatically controlled release of the pharmaceutical,substance | |
IT218609Z2 (it) | Supporto gonfiabile del busto e di altre parti del corpo umano. | |
EP0326155A3 (en) | Polyaluminum dialkyl phosphate, oil gelling agent comprising the same, and composition for external application comprising the same | |
PH24445A (en) | Pharmaceutical compositions for the therapy of cerebropathies on functional and organic base | |
EP0457127A3 (en) | Spermicidal coating | |
GR3018795T3 (en) | Emulsion-free emulsion polymers in sustained-release pharmaceutical compositions and their production | |
EP0300741A3 (de) | Humanes Thymopoietin | |
MY113423A (en) | Substituted thiophenesulfonylureas and -thioureas processes for their preparation, their use as amedicament or diagnostic, and medicament contiaining them | |
Pagnoulle | Ngugi's “Journey of the Magi”: Part II of Petals of Blood |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |