DE3918736A1 - PTFE coating for metal mesh prosthesis used in artery expansion - internal and external coatings are applied to mesh and prevent thrombosis and further arterial restriction - Google Patents

PTFE coating for metal mesh prosthesis used in artery expansion - internal and external coatings are applied to mesh and prevent thrombosis and further arterial restriction

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Publication number
DE3918736A1
DE3918736A1 DE19893918736 DE3918736A DE3918736A1 DE 3918736 A1 DE3918736 A1 DE 3918736A1 DE 19893918736 DE19893918736 DE 19893918736 DE 3918736 A DE3918736 A DE 3918736A DE 3918736 A1 DE3918736 A1 DE 3918736A1
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Prior art keywords
mesh
metal
metal mesh
ptfe
stent
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DE19893918736
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German (de)
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DE3918736C2 (en
Inventor
Christian Dr Vallbracht
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Atrium Medical Corp
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Christian Dr Vallbracht
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Priority to DE19893918736 priority Critical patent/DE3918736C2/en
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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/82Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/86Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure
    • A61F2/90Stents in a form characterised by the wire-like elements; Stents in the form characterised by a net-like or mesh-like structure characterised by a net-like or mesh-like structure
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/28Materials for coating prostheses
    • A61L27/34Macromolecular materials
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/072Encapsulated stents, e.g. wire or whole stent embedded in lining
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2/00Filters implantable into blood vessels; Prostheses, i.e. artificial substitutes or replacements for parts of the body; Appliances for connecting them with the body; Devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents
    • A61F2/02Prostheses implantable into the body
    • A61F2/04Hollow or tubular parts of organs, e.g. bladders, tracheae, bronchi or bile ducts
    • A61F2/06Blood vessels
    • A61F2/07Stent-grafts
    • A61F2002/075Stent-grafts the stent being loosely attached to the graft material, e.g. by stitching
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61FFILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F2230/00Geometry of prostheses classified in groups A61F2/00 - A61F2/26 or A61F2/82 or A61F9/00 or A61F11/00 or subgroups thereof
    • A61F2230/0002Two-dimensional shapes, e.g. cross-sections
    • A61F2230/0004Rounded shapes, e.g. with rounded corners
    • A61F2230/0013Horseshoe-shaped, e.g. crescent-shaped, C-shaped, U-shaped

Abstract

A prosthesis is described which consists of an expandable metal wire mesh (2). The prosthesis has a thin coating (3) of polytetrafluoroethylene on the inner surface. A further coating (4) can if necessary be applied to the outer surface. The PTFE (3) can be applied to the mesh (2) as a film and sintered, as a tube which can be stitched around the mesh (2) or as a dispersion which is sintered. USE/ADVANTAGE - As a prosthesis for insertion into restricted arteries for maintaining a constant expansion of the restricted canal. Onset of thrombosis is prevented and cell growth through the grid is prevented thus avoiding further arterial restriction.

Description

Gegenstand der Erfindung sind kunststoffüberzogene Metallgitter­ stents zur permanenten Dehnung von arteriellen Verengungen.The invention relates to plastic-coated metal grids stents for permanent stretching of arterial constrictions.

Nach transluminaler Dehnung von arteriellen Stenosen mit einem Ballonkatheter oder nach Wiedereröffnung komplett verschlossener Gefäße kann in vielen Fällen das Lumen nicht bleibend offen gehalten werden, da sich Teile der Intima wie ein Ventil verschließend nach innen legen.After transluminal stretching of arterial stenoses with a Balloon catheter or completely closed after reopening In many cases, vessels cannot keep the lumen open be held as parts of the intima like a valve put in a closing position.

Dies führt bei bestimmten Lokalisationen (z.B. der Koronar­ arterien) zu einer kritischen Situation, die eine notfallmäßige Bypass-Operation mit hohem Risiko für den Patienten erforderlich macht; in jedem Fall verhindert es jedoch den angestrebten Akuterfolg.This leads to certain locations (e.g. the coronary arteries) to a critical situation requiring an emergency Bypass surgery with high risk required for the patient makes; in any case, however, it prevents the desired one Acute success.

Seit einigen Jahren wird mit Gefäßendoprothesen, sogenannten Stents, experimentiert, die aus einem Geflecht von Metalldrähten (meist in Gitterform) bestehen und entweder als selbstexpan­ dierende (aktive) Stents (Sigwart, U., Puel, J. Mirkovitch, V., Joffre, F., Kappenberger, L.: "Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty", New Engl. J. Med. 316, 701 (1987) und Palmaz, J.C., Richter, G.M., Noeldge, G. et al: Intraluminal stents in atherosclerotic iliuc artery stenoses. Preliminary report of an multicenter study, Radiology 168 (1988), 727) oder mit dem Ballonkatheter an Ort und Stelle aufzudehnende (passive) Stents (Strecker, E.P., Romaniuk, R., Schneider, B., Westphal, M., Zeitler, E., Wolf, H.R.D., Freudenberg, N.: Perkutan implantierbare, durch Ballon aufdehn­ bare Gefäßprothese DMW 113 (1988), 538) vorliegen und als innere Stütze das Gefäß offenhalten. Vascular endoprostheses, so-called Stents, experimented from a mesh of metal wires (usually in the form of a grid) and either as self-expand active stents (Sigwart, U., Puel, J. Mirkovitch, V., Joffre, F., Kappenberger, L .: "Intravascular stents to prevent occlusion and restenosis after transluminal angioplasty ", New Engl. J. Med. 316, 701 (1987) and Palmaz, J.C., Richter, G.M., Noeldge, G. et al: Intraluminal stents in atherosclerotic iliuc artery stenoses. Preliminary report of an multicenter study, Radiology 168 (1988), 727) or with the balloon catheter in place and Place expanding (passive) stents (Strecker, E.P., Romaniuk, R., Schneider, B., Westphal, M., Zeitler, E., Wolf, H.R.D., Freudenberg, N .: Percutaneously implantable, balloon-expandable bare vascular prosthesis DMW 113 (1988), 538) and internal Support the jar open.  

Obwohl diese Gefäßendoprothesen aus einem blut- und gewebever­ träglichen Material, z.B. vergoldetem Stahldraht, hergestellt werden, weisen sie jedoch eine nicht zu unterschätzende Thrombogenität auf, der, um Frühverschlüsse zu vermeiden, mit hohen (potentiell gefährlichen) Dosen von gerinnungshemmenden Medikamenten begegnet werden muß. Danach, d.h. in wenigen Wochen, werden die Metalldrähte durch die Gefäß-Innenhaut, das Endothel, überwachsen, so daß eine glatte, relativ athrombogene Oberfläche entsteht. Die Hoffnung , die Rate der Rezidive durch die Einlage solcher Gefäßendoprothesen senken zu können, hat sich jedoch bisher nicht bestätigen lassen (Mahler, F., Do, D., Triller, J., Thalmann, R., Walpoth, B.:Verlaufsergebnisse nach perkutaner Einlage arterieller Endoprothesen (stents) in die Beinarterien, VASA, Suppl. 23, 176-177 (1988). Das Problem scheint in der Durchwachsung des Gitters durch Gewebszellen zu sein. Deren Wachstum, welches durch das eingeführte Stent stimuliert wurde, hört nämlich nicht nach vollständiger Umkleidung des Geflechts auf, sondern geht weiter und kann dadurch zu einem erneuten vollständigen oder teilweisen Verschluß des Gefäßes führen.Although these vascular endoprostheses consist of a blood and tissue ver inert material, e.g. gilded steel wire However, they show a not to be underestimated Thrombogenicity to prevent early occlusion with high (potentially dangerous) doses of anticoagulant Medicines must be countered. After that, i.e. in a few weeks, the metal wires through the inner lining of the vessel, the endothelium, overgrown so that a smooth, relatively athrombogenic surface arises. Hope, the rate of recurrence through the deposit to be able to lower such vascular endoprostheses, however have not yet been confirmed (Mahler, F., Do, D., Triller, J., Thalmann, R., Walpoth, B.: History results after percutaneous Insertion of arterial endoprostheses (stents) into the leg arteries, VASA, Suppl. 23, 176-177 (1988). The problem appears in the Grid growth through tissue cells. Theirs Growth stimulated by the inserted stent it does not stop after the braid has been completely covered but goes on and can thus lead to a new one complete or partial closure of the vessel.

Aufgabe der vorliegenden Erfindung war es daher, eine Gefäßendo­ prothese zu entwickeln, welche einerseits ein verengtes Gefäß dauerhaft aufweitet; andererseits nicht thrombogen wirkt und eine Durchwachsung durch Gewebszellen verhindert.The object of the present invention was therefore to provide a vascular duo to develop prosthesis, which on the one hand is a constricted vessel permanently expanding; on the other hand does not have a thrombogenic effect and prevents growth through tissue cells.

Diese Aufgabe wird überraschenderweise gelöst, indem man ein an sich bekanntes Metallgitterstent innen (und eventuell außen) mit einem dünnen Überzug aus Polytetrafluorethylen (PTFE oder PTF) überkleidet.This task is surprisingly achieved by using an well-known metal mesh stent inside (and possibly outside) with a thin coating of polytetrafluoroethylene (PTFE or PTF) overclothed.

Polytetrafluorethylen, ein Polymerisat der Formel -(CF2-CF2)n- mit n = 5000-100 000 ist ein bekanntes Produkt, welches aufgrund seiner großen chemischen Beständigkeit in großem Umfang für vielfältige Beschichtungen und Auskleidungen im chemischen Apparatebau verwendet wird. Seit einiger Zeit findet dieses Material auch medizinische Anwendung zur Beschichtung von Gelenkprothesen. Seit längerem werden dünne Schläuche aus PTFE mit großem Erfolg auch als Gefäßprothesen (Bypässe) eingesetzt. Eine spezielle mikroporöse Struktur sorgt für ein organisches Verwachsen der Enden mit den zu verbindenden Gefäßen.Polytetrafluoroethylene, a polymer of the formula - (CF 2 -CF 2 ) n - with n = 5000-100 000 is a well-known product which, due to its great chemical resistance, is widely used for a wide variety of coatings and linings in chemical apparatus engineering. For some time now, this material has also been used in medicine to coat prosthetic joints. For a long time, thin tubes made of PTFE have also been used with great success as vascular prostheses (bypasses). A special microporous structure ensures an organic growth of the ends with the vessels to be connected.

Erfindungsgemäß wird entweder eine Dispersion aus PTF um ein entsprechendes Stent aus Metallgitter herumgesintert oder eine sehr dünne, von einem Block aus PTF abgeschälte Folie von innen in das Stent eingelegt und unter Erwärmen bis zu 370-380°C und/oder unter Anwendung von Druck mit dem Stent verbunden. Gegebenenfalls kann eine weitere Folie von außen um das Stent gelegt werden, um eine vollständige Einschließung des Metalls zu erreichen. Die Folie kann gegebenenfalls auch zu einem Schlauch vernäht werden.According to the invention, either a dispersion of PTF is one Corresponding stent sintered around from a metal grid or a very thin film peeled off from a block of PTF from the inside inserted into the stent and heated to 370-380 ° C and / or connected to the stent using pressure. If necessary, another film can be placed around the outside of the stent be placed to complete containment of the metal to reach. The film can optionally also form a tube to be sewn.

Auf diese Weise wird die Thrombogenität, die zu Frühverschlüssen führen kann und die Durchwachsbarkeit, die die Spätverschlüsse der Gefäßendoprothesen bewirkt, vermieden.In this way the thrombogenicity leads to early occlusion and lead to the tractability that the latex closures the vascular endoprosthesis avoided.

Da das Metall des Stents somit nicht mehr mit dem Blut und dem Gewebe in Berührung kommt, kann das Geflecht aus relativ preiswertem Stahldraht, vorzugsweise einem rostfreien Stahl, bestehen, wobei natürlich auch gewebeverträgliche Metalle genügender Härte wie Titan oder Edelmetalle eingesetzt werden können.Since the metal of the stent is no longer with the blood and the When tissue comes into contact, the braid can be made out of relative inexpensive steel wire, preferably a stainless steel, exist, of course also tissue compatible metals sufficient hardness such as titanium or precious metals can be used can.

Die erfindungsgemäßen Stents werden in üblicher Weise über einen in das Gefäß eingebrachten Katheter in die verengte Stelle eingebracht. Damit der Stent dabei das Gefäß passieren kann, muß er vorher nach Möglichkeit um den Katheter komprimiert werden, um erst am Wirkort durch die eigene Spannkraft oder mit Hilfe eines Ballon-Katheters auf die benötigte Weite ausgedehnt zu werden. The stents according to the invention are in the usual way over a catheter inserted into the vessel in the narrowed area brought in. So that the stent can pass through the vessel it should be compressed around the catheter beforehand if possible only at the site of action through your own resilience or with the help of Balloon catheter to be expanded to the required width.  

Die vorgeformte endgültige Weite beginnt bei etwa 2 mm Durch­ messer, größere Durchmesser von z.B. 3-12 mm ermöglichen den Einsatz in anderen Gefäßgebieten (z.B. Bein-, Becken- oder Nierenarterien, Aorta, Halsschlagadern, Koronararterien usw.).The preformed final width starts at about 2 mm through knife, larger diameter e.g. 3-12 mm allow the Use in other vascular areas (e.g. leg, pelvis or Renal arteries, aorta, carotid arteries, coronary arteries, etc.).

Während die bekannten, nur aus einem Metallgitter bestehenden Stents dehnbar sind und sich zusammendrücken oder durch Längsdehnung im Querschnitt verengen lassen, ist der erfindungs­ gemäße PTFE-Überzug nicht bzw. nur sehr wenig dehnbar. Die notwendige Querschnittsverringerung beim Einführen in das Gefäß wird daher vorzugsweise durch eine oder mehrere Längsfalten erreicht und der ursprüngliche Querschnitt durch Dehnung mit einem Ballon-Katheter erreicht, wobei die Falte ausgeklappt wird. Alternativ kann bei einer schraubenförmigen Metalleinlage die Querschnittsverengung durch Verdrillen erzeugt werden. Die Erfindung soll jedoch nicht auf diese Ausführungsformen beschränkt sein.While the well-known, consisting only of a metal grid Stents are stretchable and squeeze or through Allow longitudinal elongation to narrow in cross section is the fiction appropriate PTFE coating not or only very little stretch. The necessary reduction in cross-section when inserting into the vessel is therefore preferably by one or more longitudinal folds reached and the original cross section by stretching with reached a balloon catheter, the fold being unfolded. Alternatively, with a helical metal insert Cross-sectional narrowing are generated by twisting. The However, the invention is not intended to cover these embodiments be limited.

Die notwendige Flexibilität des Stents wird durch den PTFE-Über­ zug nicht beeinträchtigt; dies ist für den Einschub in Gefäß­ biegungen wichtig.The necessary flexibility of the stent is due to the PTFE over train not affected; this is for insertion in the vessel bends important.

In den folgenden Figuren ist die Erfindung näher erläutert, ohne daß diese dadurch begrenzt sein soll.The invention is explained in more detail in the following figures, without that this should be limited.

Fig. 1 zeigt ein konventionelles Metallgitterstent. Fig. 1 shows a conventional metal mesh stent.

Fig. 2 zeigt ein Metallgitterstent mit PFTE-Innenauskleidung. Fig. 2 shows a metal mesh stent with PFTE inner lining.

Fig. 3 zeigt ein Metallgitterstent mit Innenauskleidung in komprimiertem Zustand. Fig. 3 shows a metal mesh stent with an inner lining in a compressed state.

Fig. 4 zeigt ein Metallgitterstent mit Innen- und Außenbelag von PTFE. Fig. 4 shows a metal mesh stent with inner and outer coating of PTFE.

Im einzelnen zeigt die Fig. 1 ein konventionelles Metallgitter­ stent, wobei aus dünnen Drähten, die beispielsweise aus Tantal oder einem Edelmetall bestehen können, ein Schlauch (1) gewirkt ist, dessen Drahtmaschen (2) zur Einführung in ein Gefäß komprimiert oder in die Länge gezogen werden können, so daß sich der Querschnitt des Stents verringert. Nach Einbringen in das Gefäß kann das Stent dann auf den Gefäßdurchmesser wieder aufgeweitet werden.In detail, the FIG. 1 shows a conventional metal mesh stent, being knitted from thin wires, which can consist of tantalum or a noble metal, for example, a hose (1), the wire mesh (2) is compressed for introduction into a vessel or in the length can be pulled so that the cross section of the stent is reduced. After insertion into the vessel, the stent can then be expanded again to the vessel diameter.

Die Fig. 2 zeigt ein entsprechendes Metallgitterstent (1) im Querschnitt, wobei die Metalldrahtmaschen (2) durch dicke und dünne Umfangslinien angedeutet sind. Das Stent ist innen mit einer PTFE-Schicht (3) ausgekleidet, wobei aus zeichentechnischen Gründen ein Abstand zu den Drahtmaschen (2) angedeutet ist, im Gebrauch liegen Schlauch und Maschen allerdings eng aneinander. Fig. 2 shows a corresponding metal grid stent ( 1 ) in cross section, the metal wire mesh ( 2 ) being indicated by thick and thin circumferential lines. The inside of the stent is lined with a PTFE layer ( 3 ), a distance from the wire mesh ( 2 ) being indicated for technical reasons, but in use the tube and mesh are close together.

In Fig. 3 ist ein entsprechender Stent (1) aus Tantaldraht (2) mit einer Innenauskleidung aus PTFE (3) in komprimiertem Zustand abgebildet, was dadurch angedeutet ist, daß die Metalldraht­ maschen sich fast berühren. Der PTFE-Innenschlauch ist zum Ausgleich des verringerten Umfangs mit einer zusätzlichen Falte (4) abgebildet, welche sich beim Ausdehnen des Stents, wie in Fig. 2 dargestellt, glatt an das Metallgitter anliegt.In Fig. 3 a corresponding stent ( 1 ) made of tantalum wire ( 2 ) with an inner lining made of PTFE ( 3 ) is shown in a compressed state, which is indicated by the fact that the metal wire mesh almost touch. To compensate for the reduced circumference, the PTFE inner tube is shown with an additional fold ( 4 ) which, when the stent is expanded, lies flat against the metal grid, as shown in FIG. 2.

In Fig. 4 ist ein weiterer Metallgitterstent (1) mit einem Innenschlauch (3) und einem Außenmantel (5) wiedergegeben. Je nach Herstellungsweise sind diese beiden PTFE-Hüllen zwischen den Drahtmaschen (2) miteinander verbunden.In FIG. 4, a further metal mesh stent (1) is shown with an inner tube (3) and an outer jacket (5). Depending on the production method, these two PTFE sleeves are connected to one another between the wire meshes ( 2 ).

Claims (7)

1. Metallgitterstents zur permanenten Dehnung von arteriellen Verengungen, dadurch gekennzeichnet, daß sie an der Innenseite mit einem dünnen Überzug aus Polytetrafluorethylen überkleidet sind.1. Metal mesh stents for permanent expansion of arterial constrictions, characterized in that they are covered on the inside with a thin coating of polytetrafluoroethylene. 2. Metallgitterstents gemäß Ansruch 1, dadurch gekennzeichnet, daß Innen- und Außenseite mit PTFE überkleidet sind.2. Metal lattice stents according to claim 1, characterized in that that the inside and outside are covered with PTFE. 3. Metallgitterstents gemäß Anspruch 1, dadurch gekennzeichnet, daß der Überzug als Folie auf das Metallgitter aufgesintert oder als Schlauch am oder um dasselbe vernäht ist.3. Metal mesh stents according to claim 1, characterized in that that the coating is sintered onto the metal grid as a film or sewn as a hose on or around the same. 4. Metallgitterstents gemäß Anspruch 2, dadurch gekennzeichnet, daß zwei Folien um das Metallgitter herum aneinander gesintert sind.4. Metal mesh stents according to claim 2, characterized in that that two foils together around the metal grid are sintered. 5. Metallgitterstents gemäß Anspruch 2, dadurch gekennzeichnet, daß eine PTFE-Dispersion auf das Metallgitter aufgebracht und zu einem Überzug zusammengesintert ist.5. metal grid stents according to claim 2, characterized in that a PTFE dispersion is applied to the metal grid and is sintered together to form a coating. 6. Metallgitterstents gemäß Ansprüchen 1-5, dadurch gekennzeich­ net, daß der Querschnitt des Stents über eine Längsfalte veränderbar ist.6. metal mesh stents according to claims 1-5, characterized net that the cross section of the stent over a longitudinal fold is changeable. 7. Metallgitterstents gemäß Ansprüchen 1-5, dadurch gekennzeich­ net, daß der Querschnitt über eine longitudinale Verdrillung veränderbar ist.7. metal mesh stents according to claims 1-5, characterized net that the cross section has a longitudinal twist is changeable.
DE19893918736 1989-06-08 1989-06-08 Plastic-coated metal mesh stents Expired - Lifetime DE3918736C2 (en)

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DE3918736C2 DE3918736C2 (en) 1998-05-14

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Cited By (65)

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DE4102550A1 (en) * 1990-02-02 1991-08-08 Stephan Prof Dr Bockenheimer Sealing blood vessel fistula - involves inserted sleeve with spiral support with turns bridged by impervious elastic material
EP0480667A1 (en) * 1990-10-09 1992-04-15 Cook Incorporated Percutaneous stent assembly
WO1993017636A1 (en) * 1992-03-12 1993-09-16 Laboratoire Perouse Implant Expansible endoprosthesis for human or animal tubular organs and tool for positioning said endoprosthesis
WO1994003127A1 (en) * 1992-08-06 1994-02-17 William Cook Europe A/S A prosthetic device for sustaining a blood-vessel or hollow organ lumen
EP0603959A1 (en) * 1992-12-21 1994-06-29 Jean-Pierre George Emile Dereume Endoluminal prosthesis and production method
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