DE602005027229D1 - Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür - Google Patents

Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür

Info

Publication number
DE602005027229D1
DE602005027229D1 DE602005027229T DE602005027229T DE602005027229D1 DE 602005027229 D1 DE602005027229 D1 DE 602005027229D1 DE 602005027229 T DE602005027229 T DE 602005027229T DE 602005027229 T DE602005027229 T DE 602005027229T DE 602005027229 D1 DE602005027229 D1 DE 602005027229D1
Authority
DE
Germany
Prior art keywords
particles
mammal
core
therapeutic
polyphosphazine
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE602005027229T
Other languages
English (en)
Inventor
Philipp Harder
Olaf Fritz
Ulf Fritz
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Celonova Biosciences Germany GmbH
Original Assignee
Celonova Biosciences Germany GmbH
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Celonova Biosciences Germany GmbH filed Critical Celonova Biosciences Germany GmbH
Publication of DE602005027229D1 publication Critical patent/DE602005027229D1/de
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0404—X-ray contrast preparations containing barium sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
DE602005027229T 2004-10-25 2005-10-24 Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür Active DE602005027229D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US62172904P 2004-10-25 2004-10-25
US68430705P 2005-05-24 2005-05-24
PCT/IB2005/004007 WO2006046155A2 (en) 2004-10-25 2005-10-24 Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same

Publications (1)

Publication Number Publication Date
DE602005027229D1 true DE602005027229D1 (de) 2011-05-12

Family

ID=36228155

Family Applications (1)

Application Number Title Priority Date Filing Date
DE602005027229T Active DE602005027229D1 (de) 2004-10-25 2005-10-24 Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür

Country Status (14)

Country Link
US (4) US8318209B2 (de)
EP (1) EP1804773B1 (de)
JP (1) JP4885866B2 (de)
KR (1) KR101153785B1 (de)
AT (1) ATE503465T1 (de)
AU (1) AU2005298344B2 (de)
BR (1) BRPI0518383A2 (de)
CA (1) CA2584122C (de)
DE (1) DE602005027229D1 (de)
HK (1) HK1116058A1 (de)
IL (1) IL182650A (de)
MY (1) MY147841A (de)
TW (1) TW200626178A (de)
WO (1) WO2006046155A2 (de)

Families Citing this family (67)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60130743T2 (de) 2000-03-24 2008-07-17 Biosphere Medical, Inc., Rockland Mikrokugeln zur aktiven embolisierung
US9080146B2 (en) 2001-01-11 2015-07-14 Celonova Biosciences, Inc. Substrates containing polyphosphazene as matrices and substrates containing polyphosphazene with a micro-structured surface
US20080226723A1 (en) * 2002-07-05 2008-09-18 Celonova Biosciences, Inc. Loadable Polymeric Particles for Therapeutic Use in Erectile Dysfunction and Methods of Preparing and Using the Same
US20040166088A1 (en) * 2003-01-15 2004-08-26 Shalaby Shalaby W. Polymeric precursors of non-absorbable, in situ-forming hydrogels and applications thereof
US7702764B1 (en) * 2004-01-30 2010-04-20 Cisco Technology, Inc. System and method for testing network protocols
US9114162B2 (en) 2004-10-25 2015-08-25 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
US11426355B2 (en) 2004-10-25 2022-08-30 Varian Medical Systems, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
US20210299056A9 (en) 2004-10-25 2021-09-30 Varian Medical Systems, Inc. Color-Coded Polymeric Particles of Predetermined Size for Therapeutic and/or Diagnostic Applications and Related Methods
US9107850B2 (en) * 2004-10-25 2015-08-18 Celonova Biosciences, Inc. Color-coded and sized loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
BRPI0518383A2 (pt) 2004-10-25 2008-11-18 Polyzenix Gmbh partÍculas polimÉricas carregÁveis para aplicaÇÕes terepÊuticas e/ou diagnàstico e mÉtodos para preparar e usar as mesmas
CN104815331A (zh) 2005-05-09 2015-08-05 生物领域医疗公司 使用微球和非离子型造影剂的组合物和方法
DE102005023094A1 (de) * 2005-05-13 2006-11-16 Nies, Berthold, Dr. Bioaktiver Knochenzement und seine Herstellung
US20080181965A1 (en) * 2006-04-10 2008-07-31 Leon Jeffrey W Loaded latex optical molecular imaging probes
WO2007090130A2 (en) * 2006-01-30 2007-08-09 Surgica Corporation Porous intravascular embolization particles and related methods
WO2007090127A2 (en) 2006-01-30 2007-08-09 Surgica Corporation Compressible intravascular embolization particles and related methods and delivery systems
US20080234810A1 (en) * 2006-06-28 2008-09-25 Abbott Cardiovascular Systems Inc. Amorphous Glass-Coated Drug Delivery Medical Device
ES2378905T3 (es) 2006-10-10 2012-04-19 Celonova Biosciences, Inc. Válvula cardiaca bioprotésica con polifosfaceno
ES2564151T3 (es) * 2007-07-25 2016-03-18 Celonova Biosciences, Inc. Partículas poliméricas que se pueden cargar codificadas con color y dimensionadas para aplicaciones terapéuticas y/o de diagnóstico y métodos de preparación y uso de las mismas
WO2009067105A1 (en) * 2007-10-24 2009-05-28 Celonova Biosciences, Inc. Loadable polymeric particles for enhanced imaging in clinical applications and methods of preparing and using the same
WO2009054853A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for cosmetic and reconstructive tissue augmentation applications and methods of preparing and using the same
US20090110738A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Cosmetic and Reconstructive Tissue Augmentation Applications and Methods of Preparing and Using the Same
WO2009054854A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090111763A1 (en) * 2007-10-26 2009-04-30 Celonova Biosciences, Inc. Loadable polymeric particles for bone augmentation and methods of preparing and using the same
US20090110731A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Microparticles for Therapeutic Use in Alopecia and Methods of Preparing and Using the Same
WO2009058134A1 (en) * 2007-10-30 2009-05-07 Celonova Biosciences, Inc. Loadable polymeric particles for marking or masking individuals and methods of preparing and using the same
US20090110730A1 (en) * 2007-10-30 2009-04-30 Celonova Biosciences, Inc. Loadable Polymeric Particles for Marking or Masking Individuals and Methods of Preparing and Using the Same
WO2009058135A1 (en) * 2007-10-30 2009-05-07 Celonova Biosciences, Inc. Loadable polymeric microparticles for therapeutic use in alopecia and methods of preparing and using the same
WO2009058147A1 (en) * 2007-10-31 2009-05-07 Celonova Biosciences, Inc. Loadable polymeric particles for therapeutic use in erectile dysfunction
CN102176868A (zh) * 2008-02-11 2011-09-07 西洛诺瓦生物科学公司 组织紧固物品和装置以及相关方法
US20090274764A1 (en) * 2008-04-30 2009-11-05 Do Hiep Q Hollow Foam Beads for Treatment of Glioblastoma
EP2349051A1 (de) * 2008-08-20 2011-08-03 Allergan, Inc. Selbstabdichtende schale für aufblasbare prothesen
US9012240B2 (en) * 2008-08-26 2015-04-21 George Mason Research Foundation, Inc. Hydrogel nanoparticle based immunoassay
KR101061224B1 (ko) * 2008-10-08 2011-08-31 포항공과대학교 산학협력단 Ｘ 선을 이용한 유동정보 측정용 캡슐
AU2010210620B2 (en) 2009-02-03 2016-02-25 Microbion Corporation Bismuth-thiols as antiseptics for epithelial tissues, acute and chronic wounds, bacterial biofilms and other indications
US9028878B2 (en) 2009-02-03 2015-05-12 Microbion Corporation Bismuth-thiols as antiseptics for biomedical uses, including treatment of bacterial biofilms and other uses
CA2765867A1 (en) * 2009-06-19 2010-12-23 Lance Liotta Bait chemistries in hydrogel particles for serum biomarker analysis
MX371047B (es) * 2010-02-03 2020-01-14 Microbion Corp Tioles de bismuto como antisépticos para usos biomédicos, que incluyen tratamiento de biopelículas bacterianas y otros usos.
KR20130004575A (ko) 2010-02-05 2013-01-11 알러간, 인코포레이티드 팽창성 보형물 및 그의 제작방법
US8636797B2 (en) 2010-02-05 2014-01-28 Allergan, Inc. Inflatable prostheses and methods of making same
AU2011220876A1 (en) * 2010-02-23 2012-09-06 University Of Connecticut Natural polymer-based orthopedic fixation screw for bone repair and regeneration
EP2452622A1 (de) 2010-11-11 2012-05-16 Philips Intellectual Property & Standards GmbH Dickdarmuntersuchung mithilfe der Magnetpartikelabbildung
EP2699903B1 (de) * 2011-04-20 2018-07-18 Life Technologies Corporation Verfahren, zusammensetzungen und systeme zur probenablagerung
CN104363922B (zh) 2012-06-14 2017-06-30 微仙美国有限公司 聚合物治疗组合物
AU2013331439B2 (en) 2012-10-15 2016-05-12 Microvention, Inc. Polymeric treatment compositions
CN110279885B (zh) 2013-09-19 2022-07-26 泰尔茂株式会社 聚合物颗粒
KR102340388B1 (ko) 2013-09-19 2021-12-17 마이크로벤션, 인코포레이티드 중합체 필름
US9688788B2 (en) 2013-11-08 2017-06-27 Terumo Corporation Polymer particles
CN103751857A (zh) * 2014-01-22 2014-04-30 同济大学 一种载药二氧化硅栓塞微球及其制备方法
GB201415681D0 (en) * 2014-09-04 2014-10-22 Cambridge Entpr Ltd And President And Fellows Of Harvard College Protien Capsules
US9907880B2 (en) 2015-03-26 2018-03-06 Microvention, Inc. Particles
US20190070332A1 (en) 2016-03-14 2019-03-07 Biocompatibles Uk Limited Oily compositions
US10368874B2 (en) 2016-08-26 2019-08-06 Microvention, Inc. Embolic compositions
EP3518994B1 (de) 2016-09-28 2024-02-07 Terumo Corporation Polymerpartikel
US10344588B2 (en) * 2016-11-07 2019-07-09 Saudi Arabian Oil Company Polymeric tracers
JP7362598B2 (ja) 2017-10-09 2023-10-17 マイクロベンション インコーポレイテッド 放射性液体塞栓物質
AU2019315509A1 (en) 2018-07-31 2021-02-18 Microbion Corporation Bismuth-thiol compositions and methods of use
WO2020028561A1 (en) 2018-07-31 2020-02-06 Microbion Corporation Bismuth-thiol compositions and methods for treating wounds
CN108956897B (zh) * 2018-08-29 2021-10-08 西安石油大学 一种缓释型示踪剂缓释速率测定实验装置及实验方法
JP7153790B2 (ja) 2018-09-13 2022-10-14 アラーガン、インコーポレイテッド 組織伸展装置
USD896383S1 (en) 2018-09-13 2020-09-15 Allergan, Inc. Tissue expansion device
CN109289058B (zh) * 2018-10-30 2021-12-03 河北科技大学 一种不透x线标志物硫酸钡微丸及其制备方法
CN111007593B (zh) * 2019-05-12 2022-05-13 桂林电子科技大学 基于热扩散融嵌芯毛细管光纤微小粒子输运装置
US11773715B2 (en) 2020-09-03 2023-10-03 Saudi Arabian Oil Company Injecting multiple tracer tag fluids into a wellbore
US11660595B2 (en) 2021-01-04 2023-05-30 Saudi Arabian Oil Company Microfluidic chip with multiple porosity regions for reservoir modeling
US11534759B2 (en) 2021-01-22 2022-12-27 Saudi Arabian Oil Company Microfluidic chip with mixed porosities for reservoir modeling
WO2023132810A1 (en) * 2022-01-06 2023-07-13 Trakya Üni̇versi̇tesi̇ Rektörlüğü Liquid skin marker
GB2616873A (en) 2022-03-23 2023-09-27 Ide8 Ltd Superabsorbent Polymer based Biosensor Apparatus and Methods

Family Cites Families (183)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US424208A (en) * 1890-03-25 Whiffletree
SE420565B (sv) 1974-06-06 1981-10-19 Pharmacia Ab Hjelpmedel for intravaskuler administraring for anvendning i samband med intravaskuler administrering av en losning eller en suspension av ett diagnostiseringsmedel
US4107288A (en) 1974-09-18 1978-08-15 Pharmaceutical Society Of Victoria Injectable compositions, nanoparticles useful therein, and process of manufacturing same
US3949073A (en) 1974-11-18 1976-04-06 The Board Of Trustees Of Leland Stanford Junior University Process for augmenting connective mammalian tissue with in situ polymerizable native collagen solution
US4166800A (en) 1977-08-25 1979-09-04 Sandoz, Inc. Processes for preparation of microspheres
DE2905878A1 (de) 1979-02-16 1980-08-28 Merck Patent Gmbh Implantationsmaterialien und verfahren zu ihrer herstellung
FR2482112B1 (fr) 1980-05-09 1985-06-07 Pharmindustrie Nouveaux copolymeres hydrophiles a base de n-(tris (hydroxymethyl) methyl) acrylamide, procedes pour leur preparation, gels aqueux desdits copolymeres et leur utilisation comme echangeurs d'ions
US4698373A (en) 1981-01-21 1987-10-06 Dentsply Research & Development Corp. Stable one part dental compositions employing ipn technology
US4424208A (en) 1982-01-11 1984-01-03 Collagen Corporation Collagen implant material and method for augmenting soft tissue
US4440750A (en) 1982-02-12 1984-04-03 Collagen Corporation Osteogenic composition and method
US4582640A (en) 1982-03-08 1986-04-15 Collagen Corporation Injectable cross-linked collagen implant material
US4547390A (en) * 1982-03-12 1985-10-15 Medical Biological Sciences, Inc. Process of making implantable prosthesis material of modified polymeric acrylic (PMMA) beads coated with PHEMA and barium sulfate
US4535485A (en) 1982-03-12 1985-08-20 Medical Biological Sciences, Inc. Polymeric acrylic prothesis
SU1085993A1 (ru) * 1983-01-24 1984-04-15 Московский ордена Ленина и ордена Трудового Красного Знамени химико-технологический институт им.Д.И.Менделеева Способ получени гидрофильных полиорганофосфазенов
JPS59164723A (ja) 1983-03-10 1984-09-17 Koken:Kk 再生コラーゲンフイブリルを含有する基質及びその製造方法
CA1225585A (en) 1983-06-30 1987-08-18 Maria T. Litvinova Composition for embolization of blood vessels
US4837285A (en) 1984-03-27 1989-06-06 Medimatrix Collagen matrix beads for soft tissue repair
US4537916A (en) 1984-06-25 1985-08-27 The Dow Chemical Company Structured latex particles which are film forming and a process for their preparation
US4557764A (en) 1984-09-05 1985-12-10 Collagen Corporation Process for preparing malleable collagen and the product thereof
US4595713A (en) 1985-01-22 1986-06-17 Hexcel Corporation Medical putty for tissue augmentation
DE3503584C1 (de) 1985-02-02 1986-06-12 Degussa Ag, 6000 Frankfurt Verfahren zur Herstellung von Suspensionspolymerisaten
US4592755A (en) * 1985-06-11 1986-06-03 Ethyl Corporation Mammary implant
US4851046A (en) 1985-06-19 1989-07-25 University Of Florida Periodontal osseous defect repair
JPH0678434B2 (ja) * 1985-10-14 1994-10-05 チッソ株式会社 球形粒子状ポリホスファゼン及びその製法
US4728570A (en) 1985-10-29 1988-03-01 United States Surgical Corporation Calcium-hydroxide-treated polymeric implant matrial
US4803075A (en) 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US4849285A (en) 1987-06-01 1989-07-18 Bio Med Sciences, Inc. Composite macrostructure of ceramic and organic biomaterials
US4912141A (en) 1987-07-28 1990-03-27 Kronman Joseph H Fibrous and cartilaginous tissue replacement
US4902511A (en) 1987-07-28 1990-02-20 Kronman Joseph H Fibrous and cartilaginous tissue replacement
JPH01265970A (ja) 1988-04-19 1989-10-24 Shiseido Co Ltd ヒアルロン酸を含有させたコラーゲン水溶液又は水分散液
US4938763B1 (en) 1988-10-03 1995-07-04 Atrix Lab Inc Biodegradable in-situ forming implants and method of producing the same
US5162430A (en) 1988-11-21 1992-11-10 Collagen Corporation Collagen-polymer conjugates
US5306500A (en) 1988-11-21 1994-04-26 Collagen Corporation Method of augmenting tissue with collagen-polymer conjugates
US5304595A (en) 1988-11-21 1994-04-19 Collagen Corporation Collagen-polymer conjugates
US5510418A (en) 1988-11-21 1996-04-23 Collagen Corporation Glycosaminoglycan-synthetic polymer conjugates
DE3841401A1 (de) 1988-12-08 1990-06-13 Martin Lemperle Alloplastisches implantat
US5258028A (en) 1988-12-12 1993-11-02 Ersek Robert A Textured micro implants
US5395620A (en) 1989-01-31 1995-03-07 Coletica Biodegradable microcapsules having walls composed of crosslinked atelocollagen and polyholoside
US5019400A (en) 1989-05-01 1991-05-28 Enzytech, Inc. Very low temperature casting of controlled release microspheres
US5158573A (en) 1989-06-09 1992-10-27 American Medical Systems, Inc. Injectable polymeric bodies
US5007940A (en) 1989-06-09 1991-04-16 American Medical Systems, Inc. Injectable polymeric bodies
US5116387A (en) 1989-06-09 1992-05-26 American Medical Systems, Inc. Preparation of injectable polymeric bodies
US5077049A (en) 1989-07-24 1991-12-31 Vipont Pharmaceutical, Inc. Biodegradable system for regenerating the periodontium
US5487897A (en) 1989-07-24 1996-01-30 Atrix Laboratories, Inc. Biodegradable implant precursor
WO1991001720A1 (en) 1989-08-07 1991-02-21 Herman Wade Schlameus Composition and method of promoting hard tissue healing
US5143724A (en) 1990-07-09 1992-09-01 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
US5246698A (en) 1990-07-09 1993-09-21 Biomatrix, Inc. Biocompatible viscoelastic gel slurries, their preparation and use
DE4024371C2 (de) 1990-08-01 1994-10-13 Degussa Verfahren zur Herstellung von Suspensionspolymerisaten unter Verwendung von Phosphonsäuren bzw. deren Ammonium- oder Alkalimetallsalzen als Dispergierhilfsmittel-Additive
US5487390A (en) 1990-10-05 1996-01-30 Massachusetts Institute Of Technology Gas-filled polymeric microbubbles for ultrasound imaging
US5562099A (en) * 1990-10-05 1996-10-08 Massachusetts Institute Of Technology Polymeric microparticles containing agents for imaging
US5149543A (en) 1990-10-05 1992-09-22 Massachusetts Institute Of Technology Ionically cross-linked polymeric microcapsules
US5342557A (en) 1990-11-27 1994-08-30 United States Surgical Corporation Process for preparing polymer particles
US6391343B1 (en) 1991-01-15 2002-05-21 Hemosphere, Inc. Fibrinogen-coated particles for therapeutic use
CA2060223C (en) 1991-02-12 1999-07-20 Clarence C. Lee Injectable medical lubricating fluid composition and method of use
FR2676927B1 (fr) 1991-05-29 1995-06-23 Ibf Microspheres utilisables pour les occlusions vasculaires therapeutiques et solutions injectables les contenant.
CA2071137A1 (en) 1991-07-10 1993-01-11 Clarence C. Lee Composition and method for revitalizing scar tissue
JP3356447B2 (ja) 1991-10-16 2002-12-16 テルモ株式会社 乾燥高分子ゲルからなる血管病変塞栓材料
US7060287B1 (en) 1992-02-11 2006-06-13 Bioform Inc. Tissue augmentation material and method
US7968110B2 (en) 1992-02-11 2011-06-28 Merz Aesthetics, Inc. Tissue augmentation material and method
US6537574B1 (en) 1992-02-11 2003-03-25 Bioform, Inc. Soft tissue augmentation material
ATE269371T1 (de) 1992-02-28 2004-07-15 Cohesion Tech Inc Injektierbare, keramische verbindungen sowie verfahren zu deren herstellung und anwendung
US5204382A (en) 1992-02-28 1993-04-20 Collagen Corporation Injectable ceramic compositions and methods for their preparation and use
DK0632820T3 (da) 1992-02-28 2000-10-02 Collagen Corp Højkoncentrerede, homogeniserede collagensammensætninger
US6235313B1 (en) 1992-04-24 2001-05-22 Brown University Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
AU4926193A (en) 1992-09-21 1994-04-12 Vitaphore Corporation Embolization plugs for blood vessels
CA2158638C (en) 1993-03-19 1999-11-30 Bengt Agerup A composition and a method for tissue augmentation
US5562909A (en) 1993-07-12 1996-10-08 Massachusetts Institute Of Technology Phosphazene polyelectrolytes as immunoadjuvants
US5397352A (en) 1993-08-27 1995-03-14 Burres; Steven Method of recollagenation
US5500161A (en) 1993-09-21 1996-03-19 Massachusetts Institute Of Technology And Virus Research Institute Method for making hydrophobic polymeric microparticles
US5681873A (en) 1993-10-14 1997-10-28 Atrix Laboratories, Inc. Biodegradable polymeric composition
US5962427A (en) 1994-02-18 1999-10-05 The Regent Of The University Of Michigan In vivo gene transfer methods for wound healing
US5464932A (en) 1994-04-15 1995-11-07 The Penn State Research Foundation Photocrosslinkable polyphosphazenes and their use as microencapsulation materials
FR2721198B1 (fr) 1994-06-16 1996-10-31 Caravel Jean Baudoin Prothèse implantable souple, utilisée en chirurgie pour l'augmentation de volume ou la reconstruction des tissus mous, notamment prothèse mammaire.
US5855895A (en) 1995-06-07 1999-01-05 Virus Research Institute Polyphosphazene polyelectrolyte immunoadjuvants
US5451406A (en) 1994-07-14 1995-09-19 Advanced Uroscience, Inc. Tissue injectable composition and method of use
US5516532A (en) 1994-08-05 1996-05-14 Children's Medical Center Corporation Injectable non-immunogenic cartilage and bone preparation
AU706434B2 (en) 1994-10-18 1999-06-17 Ethicon Inc. Injectable liquid copolymers for soft tissue repair and augmentation
US6335383B1 (en) 1994-10-18 2002-01-01 Ethicon, Inc. Microdispersions for coating surgical devices
US5599852A (en) 1994-10-18 1997-02-04 Ethicon, Inc. Injectable microdispersions for soft tissue repair and augmentation
EP0713707A1 (de) 1994-11-23 1996-05-29 Collagen Corporation Injizierbare, in Situ vernetzbare Kollagenszusammensetzung für die Weichgewebevermehrung
US6281015B1 (en) 1994-12-16 2001-08-28 Children's Medical Center Corp. Localized delivery of factors enhancing survival of transplanted cells
US6962979B1 (en) 1995-03-14 2005-11-08 Cohesion Technologies, Inc. Crosslinkable biomaterial compositions containing hydrophobic and hydrophilic crosslinking agents
US6337389B1 (en) 1995-03-17 2002-01-08 Bioscience Consultants, L.L.C. Method and process for the production of collagen preparations from invertebrate marine animals and compositions thereof
US6214331B1 (en) 1995-06-06 2001-04-10 C. R. Bard, Inc. Process for the preparation of aqueous dispersions of particles of water-soluble polymers and the particles obtained
US6284284B1 (en) 1995-06-06 2001-09-04 Advanced Tissue Sciences, Inc. Compositions and methods for production and use of an injectable naturally secreted extracellular matrix
US6413536B1 (en) 1995-06-07 2002-07-02 Southern Biosystems, Inc. High viscosity liquid controlled delivery system and medical or surgical device
US5776193A (en) 1995-10-16 1998-07-07 Orquest, Inc. Bone grafting matrix
US6458889B1 (en) 1995-12-18 2002-10-01 Cohesion Technologies, Inc. Compositions and systems for forming crosslinked biomaterials and associated methods of preparation and use
US5752974A (en) 1995-12-18 1998-05-19 Collagen Corporation Injectable or implantable biomaterials for filling or blocking lumens and voids of the body
AU1354497A (en) 1995-12-21 1997-07-14 Drexel University Hollow polymer microcapsules and method of producing
US6387390B1 (en) 1998-10-05 2002-05-14 The Penn State Research Foundation Compositions and methods for enhancing receptor-mediated cellular internalization
FR2747682B1 (fr) 1996-04-17 1998-06-05 Atochem Elf Sa Procede pour la preparation de poudres de polymere par polymerisation en suspension
US5840290A (en) 1996-05-30 1998-11-24 University Of Florida Research Foundation Injectable bio-active glass in a dextran suspension
US6190684B1 (en) 1996-05-30 2001-02-20 University Of Florida Research Foundation, Inc. Injectable bio-active glass in a dextran suspension
JP2001508762A (ja) * 1996-06-27 2001-07-03 ジー．ディー．サール アンド カンパニー 架橋した外殻領域および内部芯領域を有する両親媒性コポリマーからなり、医薬およびその他の用途に有用な粒子
US6666892B2 (en) 1996-08-23 2003-12-23 Cook Biotech Incorporated Multi-formed collagenous biomaterial medical device
US6066325A (en) 1996-08-27 2000-05-23 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
US6063061A (en) 1996-08-27 2000-05-16 Fusion Medical Technologies, Inc. Fragmented polymeric compositions and methods for their use
AU4648697A (en) 1996-09-23 1998-04-14 Chandrashekar Pathak Methods and devices for preparing protein concentrates
US5785642A (en) * 1996-10-18 1998-07-28 Micro Therapeutics, Inc. Methods for treating urinary incontinence in mammals
BR9606075C1 (pt) 1996-12-19 2002-05-07 Mateus Sommer Neto Composição injetável para uso médico.
AU6946198A (en) 1997-04-01 1998-10-22 Cap Biotechnology, Inc. Calcium phosphate microcarriers and microspheres
DK0996426T3 (da) 1997-06-05 2007-07-02 Bertex Pharma Gmbh Multifasesystem
US7192984B2 (en) 1997-06-17 2007-03-20 Fziomed, Inc. Compositions of polyacids and polyethers and methods for their use as dermal fillers
US6309420B1 (en) 1997-10-14 2001-10-30 Parallax Medical, Inc. Enhanced visibility materials for implantation in hard tissue
US6423343B1 (en) 1998-01-23 2002-07-23 Usbiomaterials Corporation Bioactive glass treatment of inflammation in skin conditions
US6660301B1 (en) 1998-03-06 2003-12-09 Biosphere Medical, Inc. Injectable microspheres for dermal augmentation and tissue bulking
CA2322954C (en) 1998-03-06 2011-06-07 Biosepra Inc. Implantable particles for tissue bulking and the treatment of gastroesophageal reflux disease, urinary incontinence, and skin wrinkles
US6207171B1 (en) 1998-03-27 2001-03-27 Avant Immunotherapeutics, Inc. Polyphosphazene microspheres
US6933326B1 (en) 1998-06-19 2005-08-23 Lifecell Coporation Particulate acellular tissue matrix
US6514534B1 (en) 1998-08-14 2003-02-04 Incept Llc Methods for forming regional tissue adherent barriers and drug delivery systems
GB2345638A (en) 1998-09-11 2000-07-19 Tissue Science Lab Limited Injectable collagen compositions
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
FR2784580B1 (fr) 1998-10-16 2004-06-25 Biosepra Inc Microspheres de polyvinyl-alcool et procedes de fabrication de celles-ci
US6261573B1 (en) 1998-10-30 2001-07-17 Avant Immunotherapeutics, Inc. Immunoadjuvants
US6238335B1 (en) 1998-12-11 2001-05-29 Enteric Medical Technologies, Inc. Method for treating gastroesophageal reflux disease and apparatus for use therewith
US6251064B1 (en) 1998-12-11 2001-06-26 Enteric Medical Technologies, Inc. Method for creating valve-like mechanism in natural body passageway
US20020016637A1 (en) 1998-12-16 2002-02-07 Mark A. Anton Soft tissue filler
IT1302534B1 (it) 1998-12-21 2000-09-05 Fidia Advanced Biopolymers Srl Composizioni iniettabili, biocompatibili e biodegradabili comprendentialmeno un derivato dell'acido ialuronico, cellule condrogeniche, per
EP1031354A3 (de) 1999-01-19 2003-02-05 Rohm And Haas Company Polymere MRI Kontrastmittel
US6662805B2 (en) 1999-03-24 2003-12-16 The Johns Hopkins University Method for composite cell-based implants
US6689823B1 (en) 1999-03-31 2004-02-10 The Brigham And Women's Hospital, Inc. Nanocomposite surgical materials and method of producing them
US6423818B1 (en) 1999-07-30 2002-07-23 Takehisa Matsuda Coumarin endcapped absorbable polymers
US7025980B1 (en) 1999-09-14 2006-04-11 Tepha, Inc. Polyhydroxyalkanoate compositions for soft tissue repair, augmentation, and viscosupplementation
US6277392B1 (en) 1999-09-16 2001-08-21 Carbon Medical Technologies, Inc. Tissue injectable composition
US6431174B1 (en) 2000-08-10 2002-08-13 Pi Medical, Inc. Method and apparatus to treat conditions of the naso-pharyngeal area
US6458387B1 (en) 1999-10-18 2002-10-01 Epic Therapeutics, Inc. Sustained release microspheres
US7004977B2 (en) 1999-11-24 2006-02-28 A Enterprises, Inc. Soft tissue substitute and method of soft tissue reformation
DE60130544T2 (de) 2000-03-13 2008-06-26 Biocure, Inc. Embolische zusammensetzungen
CA2427543A1 (en) 2000-03-15 2004-11-02 Yu-Ling Cheng Thermally reversible implant and filler
ES2222352T3 (es) * 2000-03-18 2005-02-01 Polyzenix Gmbh Uso de derivados de polifosfaceno para recubrimientos antibacterianos.
US7338657B2 (en) 2001-03-15 2008-03-04 Biosphere Medical, Inc. Injectable microspheres for tissue construction
US6436424B1 (en) 2000-03-20 2002-08-20 Biosphere Medical, Inc. Injectable and swellable microspheres for dermal augmentation
DE60130743T2 (de) 2000-03-24 2008-07-17 Biosphere Medical, Inc., Rockland Mikrokugeln zur aktiven embolisierung
US6263930B1 (en) 2000-04-11 2001-07-24 Scott A. Wiley Stump grinder
US7265199B2 (en) * 2000-04-11 2007-09-04 Celonova Biosciences Germany Gmbh Poly-tri-fluoro-ethoxypolyphosphazene coverings and films
US6682760B2 (en) 2000-04-18 2004-01-27 Colbar R&D Ltd. Cross-linked collagen matrices and methods for their preparation
US6869445B1 (en) 2000-05-04 2005-03-22 Phillips Plastics Corp. Packable ceramic beads for bone repair
US6423332B1 (en) 2000-05-26 2002-07-23 Ethicon, Inc. Method and composition for deforming soft tissues
US6620185B1 (en) 2000-06-27 2003-09-16 Smith & Nephew, Inc. Surgical procedures and instruments
US7144414B2 (en) 2000-06-27 2006-12-05 Smith & Nephew, Inc. Surgical procedures and instruments
WO2002011696A2 (en) 2000-08-08 2002-02-14 Ev & M Active tissue augmentation materials and method
EP1179353A1 (de) * 2000-08-11 2002-02-13 B. Braun Melsungen Ag Antithrombogene Implantate mit Beschichtung aus Polyphosphazenen und einem pharmakologisch aktiven Wirkstoff
US6858634B2 (en) 2000-09-15 2005-02-22 Monsanto Technology Llc Controlled release formulations and methods for their production and use
US20040047892A1 (en) 2000-11-15 2004-03-11 Desrosiers Eric Andre Filler composition for soft tissue augmentation and reconstructive surgery
US6767637B2 (en) 2000-12-13 2004-07-27 Purdue Research Foundation Microencapsulation using ultrasonic atomizers
DE10100961B4 (de) * 2001-01-11 2005-08-04 Polyzenix Gmbh Körperverträglicher Werkstoff und mit diesem Werkstoff beschichtetes Substrat für die Züchtung von Zellen und künstlichen aus Zellen aufgebauten oder gewachsenen organischen Implantaten
US6949251B2 (en) 2001-03-02 2005-09-27 Stryker Corporation Porous β-tricalcium phosphate granules for regeneration of bone tissue
US20070191964A1 (en) 2001-04-04 2007-08-16 Arthrocare Corporation Enhanced visibility materials for implantation in hard tissue
GB0115320D0 (en) 2001-06-22 2001-08-15 Univ Nottingham Matrix
EP1411861B1 (de) 2001-06-29 2012-04-04 Medgraft Microtech, Inc. Biologisch abbaubare injizierbare implantate und verwandte herstellungs- und verwendungsmethoden
US6967234B2 (en) 2002-12-18 2005-11-22 Ethicon, Inc. Alkyd-lactone copolymers for medical applications
US7131997B2 (en) 2002-03-29 2006-11-07 Scimed Life Systems, Inc. Tissue treatment
US7094369B2 (en) 2002-03-29 2006-08-22 Scimed Life Systems, Inc. Processes for manufacturing polymeric microspheres
US7053134B2 (en) 2002-04-04 2006-05-30 Scimed Life Systems, Inc. Forming a chemically cross-linked particle of a desired shape and diameter
US6713646B2 (en) 2002-04-12 2004-03-30 Biosphere Medical Degradable crosslinkers, and degradable crosslinked hydrogels comprising them
WO2003091337A1 (en) 2002-04-24 2003-11-06 Rutgers, The State University New polyarylates for drug delivery and tissue engineering
US7838699B2 (en) 2002-05-08 2010-11-23 Biosphere Medical Embolization using degradable crosslinked hydrogels
US20040028676A1 (en) 2002-08-06 2004-02-12 Klein Dean A. Swallowing system tissue modifier
US7026374B2 (en) 2002-06-25 2006-04-11 Aruna Nathan Injectable microdispersions for medical applications
US7272144B2 (en) 2002-06-26 2007-09-18 Arris International, Inc. Method and apparatus for queuing data flows
AU2003246387A1 (en) * 2002-07-05 2004-01-23 Celonova Biosciences Germany Gmbh Implant for transport and release for pharmacologically active agents as well as a process for producing the same
US20050136093A1 (en) * 2002-07-05 2005-06-23 Polyzenix Gmbh Implant for transport and release for pharmacologically active agents as well as a process for producing the same
US6884905B2 (en) 2002-07-23 2005-04-26 Biosphere Medical Degradable carbamate-containing bis(acryloyl) crosslinkers, and degradable crosslinked hydrogels comprising them
US6872799B2 (en) 2002-12-18 2005-03-29 Ethicon, Inc. Functionalized polymers for medical applications
US6866860B2 (en) 2002-12-19 2005-03-15 Ethicon, Inc. Cationic alkyd polyesters for medical applications
US7655048B2 (en) 2003-04-02 2010-02-02 Furlow Jr Leonard T Materials and methods for soft tissue augmentation
US20050037047A1 (en) 2003-08-11 2005-02-17 Young-Ho Song Medical devices comprising spray dried microparticles
CA2536041A1 (en) 2003-11-10 2005-05-26 Angiotech International Ag Medical implants and fibrosis-inducing agents
US20050208095A1 (en) 2003-11-20 2005-09-22 Angiotech International Ag Polymer compositions and methods for their use
TW200603843A (en) 2004-04-20 2006-02-01 Technology Dev Company Ltd Tissue enhancement implant and method
WO2006036203A2 (en) * 2004-04-20 2006-04-06 Parallel Solutions, Inc. Polyphosphazenes including ionic or ionizable moieties and fluorine-containing moieties
US7244270B2 (en) 2004-09-16 2007-07-17 Evera Medical Systems and devices for soft tissue augmentation
JP5079510B2 (ja) 2004-09-24 2012-11-21 バイオスフィア メディカル， インコーポレイテッド 放射性同位体を結合し得、任意選択的に金属微粒子を含むミクロスフェア、およびそれらの使用方法
BRPI0518383A2 (pt) 2004-10-25 2008-11-18 Polyzenix Gmbh partÍculas polimÉricas carregÁveis para aplicaÇÕes terepÊuticas e/ou diagnàstico e mÉtodos para preparar e usar as mesmas
US20070009612A1 (en) * 2004-12-16 2007-01-11 Barefoot Robert R Method for administering a composition to an animal
CN104815331A (zh) 2005-05-09 2015-08-05 生物领域医疗公司 使用微球和非离子型造影剂的组合物和方法
US8263109B2 (en) 2005-05-09 2012-09-11 Boston Scientific Scimed, Inc. Injectable bulking compositions
CA2610592A1 (en) 2005-06-16 2006-12-28 Artes Medical, Inc. Liquid crystal polymer syringes and containers and methods of use for long term storage of filler materials
US20070077544A1 (en) 2005-06-16 2007-04-05 Gottfried Lemperle Life-like anatomic feature for testing injection of soft tissue fillers
US20070100449A1 (en) 2005-10-31 2007-05-03 O'neil Michael Injectable soft tissue fixation technique
US8673019B2 (en) 2006-04-13 2014-03-18 Warsaw Orthopedic, Inc. Use of anti-inflammatory compounds with allograft tissue implantation
US20080058954A1 (en) 2006-08-22 2008-03-06 Hai Trieu Methods of treating spinal injuries using injectable flowable compositions comprising organic materials

Also Published As

Publication number Publication date
US9511153B2 (en) 2016-12-06
HK1116058A1 (en) 2008-12-19
US20130052142A1 (en) 2013-02-28
ATE503465T1 (de) 2011-04-15
JP4885866B2 (ja) 2012-02-29
BRPI0518383A2 (pt) 2008-11-18
MY147841A (en) 2013-01-31
KR20070084341A (ko) 2007-08-24
TW200626178A (en) 2006-08-01
WO2006046155A3 (en) 2006-08-17
US20170172933A1 (en) 2017-06-22
IL182650A (en) 2013-01-31
EP1804773B1 (de) 2011-03-30
KR101153785B1 (ko) 2012-07-09
US20060088476A1 (en) 2006-04-27
EP1804773A2 (de) 2007-07-11
AU2005298344A1 (en) 2006-05-04
US20210290555A1 (en) 2021-09-23
IL182650A0 (en) 2007-07-24
US8318209B2 (en) 2012-11-27
AU2005298344B2 (en) 2011-02-10
CA2584122A1 (en) 2006-05-04
WO2006046155A2 (en) 2006-05-04
CA2584122C (en) 2013-04-30
JP2008517899A (ja) 2008-05-29
US11052050B2 (en) 2021-07-06

Similar Documents

Publication Publication Date Title
DE602005027229D1 (de) Beladbare polyphosphazenhaltige teilchen für therapeutische und/oder diagnostische anwendungen sowie herstellungs- und verwendungsverfahren dafür
JP5415262B2 (ja) 活性剤送達用の涙点プラグ
US20070208134A1 (en) Anti-scarring drug combinations and use thereof
US20070299043A1 (en) Anti-scarring drug combinations and use thereof
JP2010533225A5 (de)
PT1133269E (pt) Sistema de libertação controlada para a administração de agêntes terapêuticos no interior do ouvido interno
WO2010129545A3 (en) Porous silicon drug-eluting particles
BRPI0820800B8 (pt) dispositivo médico implantável para liberação controlada de droga
AU2008261901A1 (en) Topical poloxamer formulations for enhancing microvascular flow: compositions and uses thereof
JP2017508749A (ja) 薬物送達システム及びゲムシタビンによる膀胱がんの治療方法
JP2021049427A (ja) 涙器系薬剤送達装置
RU2576029C2 (ru) Способы и композиции для нанесения моксифлоксацина в ухо
US20230075003A1 (en) Methods of treating overactive bladder using trospium
CN101947350A (zh) 一种偏心中空式球囊导管
KR102338402B1 (ko) 마이크로 버블을 포함하는 주입구를 가진 조직 확장기
JP2008522747A (ja) 造影剤でコーティングされた医療機器
CN201847799U (zh) 一种新型球囊导管
JP2019516496A (ja) 涙腺ドラッグ送給デバイス
CN107019843B (zh) 负压透皮给药装置
Shin et al. Brain targeted xenon protects cerebral vasculature after traumatic brain injury
Li et al. Advances in the Application of Microneedles in the Treatment of Local Organ Diseases
CN108926323A (zh) 一种带混合涂层螺纹软镜鞘的分体式膀胱硬镜
CN216725412U (zh) 一种输液港
Lesimple et al. Phase I study of topotecan in combination with concurrent radiotherapy in adults with glioblastoma
Kilicoglu et al. Case report: Mesenteric schwannoma