US5064653A - Hydrophilic foam compositions - Google Patents
Hydrophilic foam compositions Download PDFInfo
- Publication number
- US5064653A US5064653A US07/175,036 US17503688A US5064653A US 5064653 A US5064653 A US 5064653A US 17503688 A US17503688 A US 17503688A US 5064653 A US5064653 A US 5064653A
- Authority
- US
- United States
- Prior art keywords
- hydrophilic
- foam composition
- adjuvant
- prepolymer
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/0208—Tissues; Wipes; Patches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/26—Macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/425—Porous materials, e.g. foams or sponges
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0019—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G18/00—Polymeric products of isocyanates or isothiocyanates
- C08G18/06—Polymeric products of isocyanates or isothiocyanates with compounds having active hydrogen
- C08G18/08—Processes
- C08G18/10—Prepolymer processes involving reaction of isocyanates or isothiocyanates with compounds having active hydrogen in a first reaction step
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F2013/00361—Plasters
- A61F2013/00365—Plasters use
- A61F2013/00463—Plasters use haemostatic
- A61F2013/00472—Plasters use haemostatic with chemical means
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/53—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
- A61F2013/530481—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium having superabsorbent materials, i.e. highly absorbent polymer gel materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
- A61F13/53—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium
- A61F2013/530802—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators characterised by the absorbing medium characterized by the foam or sponge other than superabsorbent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2101/00—Manufacture of cellular products
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2110/00—Foam properties
- C08G2110/0041—Foam properties having specified density
- C08G2110/0066—≥ 150kg/m3
-
- C—CHEMISTRY; METALLURGY
- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08G—MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- C08G2110/00—Foam properties
- C08G2110/0083—Foam properties prepared using water as the sole blowing agent
Definitions
- the present invention is predicated on the discovery that a highly absorbent hydrophilic polyurethane foam composition which releasably carries an adjuvant and is capable of releasing at least a portion of the adjuvant while preferentially absorbing external liquid upon exposure of the foam composition to the external liquid, can be made by incorporating a hydrophilic agent and a releasably carried adjuvant in the foam composition. Incorporation of the adjuvant in the resulting foam is achieved by the in situ reaction of a hydrophilic isocyanate-capped polyether prepolymer, a hydrophilic agent, water, adjuvant and a wetting agent.
- the hydrophilic foam is capable of exchanging an external fluid and tightly carrying the external fluid in preference to at least a portion of the adjuvant so that upon exposure of the hydrophilic foam composition to an external fluid, such as, for example, to the exudate of a wound, the composition will absorb the external fluid and tightly carry it in preference to at least a portion of the adjuvant so that at least a portion of the adjuvant is released from the foam.
- the foam composition of the present invention When applied to a wound, the foam composition of the present invention will absorb and retain a high volume of aqueous fluid, i.e., wound exudate, and will release the adjuvant to the wound situs.
- a wound dressing which incorporates the foam composition of the present invention may be prepared which is advantageously capable of providing enhanced hemostatic and chemical debridement characteristics as well as transdermal, bacteriostatic, emollifying, demulcifying and wound cleansing characteristics.
- the concentration of prepolymer further depends on its isocyanate functionality and the degree of crosslinking desired in the final foam composition. In general, the greater the isocyanate functionality, the greater the degree of cross-linking in the cured foam matrix.
- the reactant composition will comprise from about 20% to about 60% by weight prepolymer.
- the reactant composition will comprise from about 45% to about 50% by weight of the prepolymer.
- the prepolymers may be used alone or in combination.
- the amount of adjuvant included in the reactant composition should preferably be sufficient to impart softness and pliability to the foam composition and be capable of delivering a therapeutic agent or the like, if included, to the environment of application. However, the volume of adjuvant should not be so great as to weaken or gel the composition. Generally, it has been found that the amount of adjuvant in the reactant composition should be from about 5 wt. % to about 30 wt. % of the reactant composition.
- PLURONIC F-68 is especially preferred because of its cleansing action, particularly because a portion of the surfactant may be released when the foam composition is exposed to the exudate of the wound.
- the amount of wetting agent should be from about 1% to about 10% by weight of the reactant composition, preferably from about 5% to about 7% by weight.
- the source of the water required for the foaming reaction is not critical.
- the water so required may be provided as a separate component of the reactant composition, or, for example, it may be provided by one of the other components of the reactant composition.
- the required water may be provided with an aqueous-based cosmetic which may be incorporated into the foam composition.
- the resulting foam composition has an extended cure time with decreased ability to tightly hold external liquid and it may have an oily or spongy nonuniform surface.
- the resulting foam composition has been found to be less uniform, has relatively poor flow and porosity characteristics, has relatively poor dimensional stability, and absorbs liquid at a slower rate.
- the weight ratio of prepolymer to hydrophilic agent will desirably be in the range of from about 20:1 to about 20:10 and the ratio of prepolymer to adjuvant will desirably be in the range of from about 20:2 to about 20:30.
- hydrophilic polyurethane foam composition was formulated by separately preparing an aqueous phase and an organic phase then mixing both phases at room temperature, and casting the mixture onto a film substrate.
- the aqueous phase was prepared by dissolving the alcohol, wetting agent and colorant in distilled water using a laboratory grade magnetic stirrer. It should be noted that some surfactants (especially the paste types) required heating to 150° F. before dissolution or even dispersion was possible. All other mixing was done at ambient temperature. When Pluronic F-68 was used, solution required about one hour of mixing at 1000 rpm on the stirrer to complete dissolution.
- Tightly held liquid is a measure of the relative amount of liquid retained by the sample after compression. It is determined by rolling an 8 pound roller over the sample ten times, and then, using the retained liquid formula to calculate the relative proportion of liquid that was not squeezed out of the composition.
- Examples 1-8 illustrate variations in the amount of water and in the wetting agent used in the reactant composition.
- Example 8 illustrates the wide range of the ratio of prepolymer to hydrophilic agent and prepolymer to adjuvant that can be employed in making the foam composition of this invention.
- the reactant compositions are set forth in Table I below.
- the retained liquid, tightly held liquid, extractable materials and absorption rate for the foam compositions of Examples 1 through 8 are set forth in Table II.
- the foams of Examples 9-12, 17 and 18 were acceptable. However, the foams of Examples 13 and 15 exhibited gross porosity, while the foams of Examples 14 and 16 had excessively high absorption rates, and were thus more hydrophobic.
Abstract
A hydrophilic foam composition comprising the in situ reaction product of an isocyanate-capped polyether prepolymer, a hydrophilic agent capable of absorbing water, an adjuvant comprising an alcohol, a wetting agent, and water.
Description
1. Field of the Invention
The present invention relates to novel foam products and, more particularly, to highly absorbent hydrophilic polyurethane foam compositions which have liquid release and exchange characteristics.
2. Background of the Invention
Absorbent pads, such as for use in contact with the skin for absorbing body fluids, are well known. Such pads are useful for numerous applications, including for example as a diaper, sanitary napkin, bandage, wound dressing or the like.
Absorbent pads have been made of a wide variety of materials. For example, such pads have been made using graft copolymers, as described in U.S. Pat. No. 4,055,184. The absorbent pad therein described includes an absorbent mass comprising a solid finely-divided mixture of a completely hydrolyzed starch-polyacrylonitrile graft copolymer and a non-irritating and non-toxic water-soluble basic material such as, for example, sodium bicarbonate which may be admixed with and distributed in a highly porous web or batt of cotton linters, layers of creped tissue or a mass of shredded polyurethane foam particles.
Pads in the form of a foam and which have been made from various superabsorbent materials are likewise known. For example, U.S. Pat. No. 4,394,930 discloses an absorbent foam product prepared by mixing together a solid, particulate, water-insoluble, water-swellable polymer such as "hydrogels", "hydrocolloids" or "superabsorbents" which are lightly cross-linked polymers containing a plurality of hydrophilic groups, such as carboxyl, carboxamide, sulfonate salt or hydroxyl groups, a blowing agent, and a liquid polyhydroxy organic compound and allowing the mixture to foam.
Polyurethane foams, treated and/or prepared in a manner so as to render them hydrophilic are also known. For example, U.S. Pat. No. 3,586,648 discloses a hydrophilic polyurethane foam prepared by the so-called "one-shot" technique and is stated to include a carboxymethyl cellulose or a carboxymethyl cellulose salt.
U.S. Pat. No. 4,497,914 discloses an ostomy gasket composition derived from the non-aqueous reaction of a polyisocyanate and a polyoxyalkylene polyol. A hydrophilic filler, such as hydroxyethylcellulose, hydroxypropylcellulose or mixtures thereof, are incorporated into the polyol phase prior to reaction.
Hydrophilic cross-linked polyurethane foams are disclosed in U.S. Pat. No. 3,903,232. Such foams are prepared by reacting particular isocyanate-capped polyoxyethylene polyols having an isocyanate functionality greater than two with large amounts of an aqueous reactant, preferably water. The foam is said to be useful for the absorption of body fluids and may be used for external body cleaning, for internal body usage, such as is necessary in dental and medical applications, and as intimate absorptive products such as diapers, sanitary napkins, catamenial devices and the like.
Other adsorbent pads using hydrophilic foam include U.S. Pat. No. 3,961,629, which discloses a hydrophilic polyurethane foam in which the foam pores have a surfactant coating to accelerate absorption of body fluids into the pores at medically acceptable rates. The foam is rendered hydrophilic by coating the pore walls with a thin layer of a surfactant. Hygroscopic agents such as glycerine as well as other agents, such as germicidal and therapeutic agents, may be incorporated into the foam.
U.S. Pat. No. 4,664,662 discloses an absorbent wound dressing which comprises an absorbent foam material retained in a water permeable, porous bag. The absorbent foam is preferably a hydrophilic polyurethane foam which can be made from HYPOL isocyanate-capped polyether prepolymer marketed by W. R. Grace and Co. and non-ionic surfactants. Physiologically active components such as local anaesthetics, antibacterial agents, antifungal agents and the like which are compatible with the absorbent material may be incorporated into the wound dressing.
Hydrophilic polyurethane foam compositions are also disclosed in U.S. Pat. No. 4,339,550. The hydrophilic foam composition is prepared by the "in situ" reaction of an isocyanate-capped polyether prepolymer having a functionality of from about 2 to about 8, water, and a chemically compatible, essentially non-polar, volatile organic compound. The foam is stated to be capable of achieving a sustained, controlled release of the volatile materials from the foam structure. Suitable "control release" ingredients for use in controlling the rate of release of the volatile ingredients include polyols, such as propylene glycol and glycerin, and materials classified as gums.
Despite the wide variety of known absorbent pads and polyurethane foam compositions there still remains a need for a highly absorbent hydrophilic polyurethane foam composition which releasably carries an adjuvant and which is capable of both absorbing an external liquid and releasing the adjuvant carried by the foam composition in the presence of the external liquid.
Accordingly, it is a principal object of the present invention to provide a polyurethane foam composition which is hydrophilic, highly absorbent and which releasably carries an adjuvant which is capable of being released from the foam in the presence of an external liquid which is preferentially absorbed by the foam composition. A more detailed object of the present invention is to provide a foam composition which is capable of releasing an adjuvant to a designated situs and which is capable of absorbing external liquids from that situs. A related object is to provide such a polyurethane foam composition which will tightly hold the external fluid once it is absorbed.
Another object of the invention is to provide a hydrophilic foam composition that can be prepared at ambient temperature.
It is a further object of the present invention to provide a wound dressing using a highly absorbent hydrophilic polyurethane foam composition. It is yet another object of the present invention to provide such a foam composition which includes a therapeutic, cosmetic or other like agent for release to and treatment of the situs of application. A still further object is to provide a foam composition which has hemostatic, bacteriostatic, emollifying, demulcifying and wound cleansing properties.
It is yet another object to provide a method of treating a wound by applying to the wound a wound dressing which includes a hydrophilic foam composition as described herein.
A further object of the present invention is to provide a composite for use in a wound dressing which includes a hydrophilic foam composition as described herein. Another object is to provide a method for making such a composite.
These and other objects and advantages of the present invention will be apparent from the following description of the invention.
The present invention is predicated on the discovery that a highly absorbent hydrophilic polyurethane foam composition which releasably carries an adjuvant and is capable of releasing at least a portion of the adjuvant while preferentially absorbing external liquid upon exposure of the foam composition to the external liquid, can be made by incorporating a hydrophilic agent and a releasably carried adjuvant in the foam composition. Incorporation of the adjuvant in the resulting foam is achieved by the in situ reaction of a hydrophilic isocyanate-capped polyether prepolymer, a hydrophilic agent, water, adjuvant and a wetting agent.
Thus, in one aspect, the present invention provides a hydrophilic polyurethane foam composition comprising the in situ reaction product of an isocyanate-capped polyether prepolymer, a hydrophilic agent capable of absorbing water, an adjuvant comprising a mono or polyhydric alcohol, a wetting agent for enhancing the wettability of the foam composition, and water. The hydrophilic foam is capable of exchanging an external fluid and tightly carrying the external fluid in preference to at least a portion of the adjuvant so that upon exposure of the hydrophilic foam composition to an external fluid, such as, for example, to the exudate of a wound, the composition will absorb the external fluid and tightly carry it in preference to at least a portion of the adjuvant so that at least a portion of the adjuvant is released from the foam.
In another aspect, the present invention provides a novel wound dressing which incorporates the novel hydrophilic polyurethane foam. In yet another aspect, the present invention provides a method of treating a wound which includes applying to the wound the novel hydrophilic foam composition disclosed herein or a wound dressing made therefrom. In still other aspects of the invention, composites which include the hydrophilic foam composition described herein and a method for making such composites are provided.
While the invention will be described in connection with the preferred embodiments, it will be understood that the invention is not intended to be so limited. On the contrary, it is intended to cover all alternatives, modifications and equivalents as may be included within the spirit and scope of the invention as defined by the appended claims. As an example, while the present invention will be described herein in relation to the use of the highly absorbent hydrophilic foam composition as a wound dressing, it should be appreciated that the foam composition of this invention is likewise useful in other applications where it is desired to releasably carry an adjuvant to a situs for subsequent application and to absorb an external liquid, such as water, from the situs of application. Such uses include, for example, cosmetic applications.
In accordance with the present invention there is provided a highly absorbent hydrophilic polyurethane foam composition which includes a releasably carried adjuvant which is capable of being emitted from the composition in the presence of an external liquid. The foam composition of this invention is the in situ reaction product of a reactant composition comprising an isocyanate-capped polyether prepolymer, a hydrophilic agent, an adjuvant, water and a surfactant or wetting agent.
In keeping with the invention, the hydrophilic foam composition, when applied to a moisture laden surface will preferentially absorb moisture from that surface while releasing the adjuvant carried by the composition. The hydrophilic polyurethane foam composition of the present invention is particularly useful as the absorbent pad of an occlusive or semi-occlusive wound dressing, commonly applied to injuries such as abrasions, incisions, punctures, lacerations, ulcers, sores, burns and the like to aid in stopping bleeding and in protecting the wound from contamination.
When applied to a wound, the foam composition of the present invention will absorb and retain a high volume of aqueous fluid, i.e., wound exudate, and will release the adjuvant to the wound situs. By proper selection of the adjuvant and, optionally, additives, such as therapeutic agents, medicaments and the like incorporated into the foam and releasably carried with the adjuvant, a wound dressing which incorporates the foam composition of the present invention may be prepared which is advantageously capable of providing enhanced hemostatic and chemical debridement characteristics as well as transdermal, bacteriostatic, emollifying, demulcifying and wound cleansing characteristics.
Once affixed to the skin surface, the foam composition absorbs exudate moisture from the wound. In absorbing the exudate moisture, the foam swells to conform to the wound contour so as to become thermally insulative to the surface of application, while at the same time holding moisture against the surface in order to keep that surface moist. The foam composition will then assist in maintaining a warm, moist and sealed wound with appropriate pH to promote epidermal resurfacing and re-epithelization. A wound dressing which includes the foam composition of the present invention does not adhere to the wound and thus does not cause reinjury upon its removal from the wound. This is believed to be due to the liquid exchange and the maintenance of a moist environment about the wound.
The hydrophilic polyurethane foam compositions of the present invention are prepared using an isocyanate-capped polyether prepolymer. Generally, these prepolymers must be safe for use in the human body, and are preferably capable of foaming in an aqueous system in the absence of a catalyst. On the other hand, such prepolymers should not dissolve in the aqueous liquid. Additionally, it is highly desirable that these prepolymers cure to form a porous cellular foam matrix to enable both absorption of external fluids and carriage of the chosen adjuvant in the foam composition. The formation of a cellular foam matrix is preferred due to a large volume available not only for absorption but the containment of the chosen adjuvant. It is further desirable that the prepolymers are capable of curing in the presence of water, in the absence of catalyst, and at ambient temperature.
Isocyanate-capped polyether prepolymers such as those disclosed in U.S. Pat. Nos. 3,903,232 and U.S. Pat. No. 4,137,200 are suitable for use in the present invention. These prepolymers have a defined average isocyanate functionality greater than 2. These prepolymers may be capped with aromatic isocyanates, such as, for example, toluene diisocyanate or methylene diphenyl isocyanate, or with aliphatic isocyanates, such as isophorone diisocyanate. Isocyanate-capped polyether prepolymers which have been found suitable for use in the practice of the present invention include prepolymers sold under the trademark HYPOL. Examples include HYPOL FHP 2000, HYPOL FHP 2002, HYPOL FHP 3000, HYPOL FHP 4000, HYPOL FHP 5000, HYPOL X6100 and HYPOL hydrogel.
HYPOL 2000, HYPOL 2002 and HYPOL 3000 prepolymers are derived from toluene diisocyanate. FHP 2000 and FHP 2002 both have an equivalent weight (per NCO) of 625, an NCO content of 1.60 meq/g and a specific gravity of 1.19. The viscosity of FHP 2000 is 18,500 cps (Brookfield LVF, #4 Spindle, 12 rpm at 25° C.) and that of FHP 2002 is 20,000. FHP 3000 has an equivalent weight (per NCO) of 425, an NCO content of 2.35 meq/g, a specific gravity of 1.15 and a viscosity (measured as described above) of 10,500. HYPOL hydrogel is likewise derived from toluene diisocyanate. It has an NCO content of 0.5-0.9 meq/g and a viscosity of 10,000 to 12,000 cps at 25° C.
Another example of an isocyanate-capped prepolymer suitable for use in the present invention and derived from toluene diisocyanate is AQUAPOL prepolymer, commercially available from Freeman Chemical Corporation. AQUAPOL prepolymers have an NCO-value of 2.5 to 3.0 and are formed from the reaction of toluene diisocyanate and an organic polyether polyol containing at least 40 percent by weight ethylene oxide adducts as described at Col. 2, lines 3-22 of U.S. Pat. No. 4,517,326.
A further example of an isocyanate-capped prepolymer suitable for use in the present invention and which is derived from toluene diisocyanate is sold under the trademark TREPOL, and is commercially available from Twin Rivers Engineering. TREPOL prepolymers have an --NCO content of 1.4 milliequivalents per gram and a viscosity at 90° C. of 4,700 cps.
The HYPOL FHP 4000 and HYPOL FHP 5000 prepolymers are derived from methylene diisocyanate. FHP 4000 has an equivalent weight (per NCO) of 476, an NCO content of 2.10 meq/g, a Brookfield viscosity (LVF, #4 Spindle, 12 r.p.m. at 25° C.) of 20,000 and specific gravity of 1.17. FHP 5000 has an equivalent weight (per NCO) of 392, an NCO content of 2.55 meq/g, a Brookfield viscosity (measured as for FHP 4000) of 18,000 and a specific gravity of 1.17.
An example of an isocyanate-capped prepolymer suitable for use in the present invention and derived from isophorone diisocyanate is HYPOL X6100. It has an --NCO content of 1.8 meq/grams and a viscosity at 25° C. of 12,000 cps.
The amount of prepolymer in the reactant composition used to prepare the hydrophilic foam composition is not particularly critical, but depends on a number of factors, including the proportion of other components in the reactant composition as will be described in greater detail hereinafter. However, there should be sufficient prepolymer to form a polyurethane foam, to releasably contain the adjuvant and to adequately contain the hydrophilic agent. To that end, the ratio of prepolymer to hydrophilic agent should be such that the reactant composition does not degrade or break up into its separate constituents. Furthermore, while there should be sufficient prepolymer to provide integrity to the foam matrix, there should not be so much prepolymer that the resulting polyurethane composition becomes unworkable. In short, and particularly where the final composition is to be applied to the skin, the resulting foam composition is desirably relatively smooth and soft while exhibiting the desired absorbence characteristics so that it does not irritate or otherwise harm the skin.
The concentration of prepolymer further depends on its isocyanate functionality and the degree of crosslinking desired in the final foam composition. In general, the greater the isocyanate functionality, the greater the degree of cross-linking in the cured foam matrix. Typically, the reactant composition will comprise from about 20% to about 60% by weight prepolymer. Preferably the reactant composition will comprise from about 45% to about 50% by weight of the prepolymer. Advantageously, the prepolymers may be used alone or in combination.
The reactant composition further includes a hydrophilic agent which is incorporated into the foam composition to absorb external liquid, such as wound exudate, and to retain such liquid in the composition. When applied to a wound, the hydrophilic agent is believed to work in conjunction with the foam matrix to hold moisture at the surface of the wound. This allows healing agents exuded by the wound to be concentrated and held at the wound surface. At the same time, the hydrophilic agent incorporated into the composition is believed to absorb fluid from the wound to assist thickening of the blood, i.e., it serves as a hemostat. The absorption of exudate by the hydrophilic agent, and the subsequent swelling of the agent results in the removal of inflammatory exudates and particles that would otherwise hinder tissue repair or cause eschar formation. Necrotic debris and bacteria are likewise removed as autolysis, i.e. chemical debridement is stimulated.
The hydrophilic agent is preferably a highly absorbent polymer, commonly known as a superabsorbent polymer. One measure of polymer absorbency is its fluid uptake capability, well known by those skilled in the art. Hydrophilic agents suitable for use in the present invention include polymers that are capable of absorbing at least 50 times their weight of water, that is, such agents have a fluid uptake of at least 50 ml/g. Hydrophilic agents having an even higher fluid uptake, such as of at least about 100 ml/g and even higher, that is, at least about 150 ml/g are preferred. Suitable superabsorbent polymers include sodium and aluminum salts of starch grafted copolymers of acrylates and acrylamides and combinations thereof, as well as polyacrylate salts. Of course, other absorbent materials may be used in combination with such highly absorbent polymers, provided the fluid uptake of the overall combination used for the hydrophilic agent is greater than 50 ml/g. When such agents are employed, either alone or in combination, the resulting foam composition desirably has the ability to hold at least about 3 times its weight in liquid. In the preferred embodiment, the resulting foam composition will have the ability to tightly hold at least about 3 times its weight in fluid. As used herein "tightly hold" or "tightly bound" liquid means the relative amount of liquid retained by the sample after compression, as described in detail hereinafter.
Hydrophilic polymers which have been found suitable for use in the foam composition of this invention are commercially available from Grain Processing Corporation. These polymers include a starch-g-poly(2-propenamide-co-2-propenoic acid, mixed sodium and aluminum salt) sold under the trademark WATER LOCK A-222; a starch-graft copolymer of polyacrylic acid and polyacrylamide having the chemical name starch-g-poly(2-propenamide-co-2-propenoic acid, sodium salt), sold under the trademark WATER LOCK A-100; a starch g-poly(2-propenamide-co-2-propenoic acid, sodium salt), sold under the trademark WATER LOCK A-200. Superabsorbent polymers commercially available from Grain Processing Corporation under the trademark WATER LOCK D-212 and WATER LOCK D-242 are likewise suitable. These polymers have the chemical name starch-g-poly(2-propenamide-co-2-propenoic acid, mixed sodium and aluminum salt). The superabsorbent polymer commercially available under the trademark WATER LOCK G-400 is also suitable for use in the making of the hydrophilic foam composition of the present invention. This superabsorbent polymer may be chemically identified as a poly(2-propenamide-co-2-propenoic acid, sodium salt). Other super absorbent powders suitable for use in the present invention are sold by Grain Processing Corporation under the trademark WATER LOCK B, C, and H.
Another example of a suitable superabsorbent polymer is poly-2-propenoic acid, sodium salt, sold under the trademark AQUA KEEP J-500 supplied by Sanyo Corp. In addition, super absorbent polymers sold by Arakawa Chemical (USA) Inc. under the trademark ARASORB are suitable. The preferred hydrophilic polymers are WATER LOCK A-100, A-200, A-222 and AQUA KEEP J-500. The hydrophilic polymers may be used alone, or in combination to achieve the desired absorptivity characteristics in the foam composition.
The hydrophilic agent may comprise additives in addition to the superabsorbent polymers, provided, as discussed above, the additives do not reduce the fluid uptake of the hydrophilic agent to below about 50 ml water per gram of hydrophilic agent and the fluid uptake of the final foam composition is not less than about 3 times its weight. Examples of such additives include methylcellulose, guar gum, pectin, karaya gum, chitosan, agar, acacia powder, carrageenan, gelatin and combinations thereof.
The amount of hydrophilic agent used and the type of it, in terms of its fluid uptake, that may be satisfactorily used to make the foam composition is not critical, but is, instead, dependent on the intended application of the composition. Stated another way, the greater the quantity of external liquid to be absorbed, e.g., the greater the amount of wound exudate, the greater the amount of hydrophilic agent that should be employed. In the alternative, the greater the amount of wound exudate to be absorbed, the greater the fluid uptake of the hydrophilic agent used, should be. For example, for an ulcerated wound where there is a high volume of wound exudate, a hydrophilic agent with high uptake is desirable. In addition, it may well be determined that the amount of hydrophilic agent may need to be increased. On the other hand, where the foam is to be applied to a small cut or light burn it may be suitable to use less hydrophilic agent or to use a hydrophilic agent with a lower fluid uptake. Determination of the type and amount of hydrophilic agent used is well within the ability of one skilled in the art in light of the disclosure herein.
The amount of hydrophilic agent should not be so great as to undesirably reduce the strength of the foam composition or result in a loss of polymer from the foam, although some loss of hydrophilic agent may be tolerated without adversely affecting the ability of the foam to absorb external liquid. The amount of hydrophilic agent employed in the reactant composition will also depend on the absorbency of the material used. As previously indicated, it is preferable that a sufficient amount of hydrophilic agent be employed so that the resulting foam composition is capable of absorbing at least about 3 times its weight in external liquid. Typically this can be achieved by including from about 5 wt. % to about 20 wt. % hydrophilic agent in the reactant composition.
The reactant composition of this invention further includes an adjuvant; preferably, a water-soluble adjuvant. The adjuvant is releasably carried by the resulting foam composition for subsequent release to a chosen situs of application. Release of the adjuvant occurs in the presence of an external liquid, such as wound exudate, which is preferentially absorbed by the foam composition. Absorption of the external liquid causes at least a portion of the adjuvant to be released.
It will be appreciated by those skilled in the art that not all of the liquid adjuvant is necessarily released (or need it be) in the presence of the external fluid. However, a sufficient amount of adjuvant must be released in order to achieve the desired result. To that end, it will be appreciated that the efficacy of the adjuvant is realized upon its release from the foam composition to the situs of application. In the case of a wound dressing, the situs is the wound, burn or the like, itself. Release of the adjuvant thus provides beneficial treatment to the wound.
Prior to curing, the adjuvant serves as a plasticizer for the reactant composition. It extends the curing time of the composition thereby allowing it to be more thoroughly mixed and formed. Once cured, the foam composition is softened by the adjuvant, allowing the foam to be more pliable and more easily applied to the skin surface or other surface of choice. Additionally, the adjuvant may be somewhat hygroscopic lending further to the hydrophilic nature of the foam composition.
Adjuvants suitable for use in the foam composition of the present invention are mono, di and polyhydric alcohols. Preferably the adjuvants are water soluble so that they may be readily released from the composition upon contact of the foam composition with an external liquid. For wound dressing applications, it is also desirable that the adjuvant be capable of contacting skin without adverse side effects. To that end, it is also preferable that the adjuvant comprise a chemical compound that will have the ability to open the skin pores to achieve a demulcent effect to relieve pain and/or irritation and to achieve an emollient effect to soften the skin and prevent maceration. It is also preferred that the adjuvant be compatible with therapeutic or other agents which may be carried by the adjuvant for subsequent delivery to the situs of application. Suitable adjuvants include water soluble alcohols, including monols, diols and polyhydric alcohols. Examples of monols include ethyl alcohol and isopropyl alcohol. Exemplary of suitable diols are propylene glycol, polyethylene glycol and polypropylene glycol. Exemplary of suitable polyhydric alcohols are glycerin, 1,2,4-butanetriol, trimethylolpropane, pentaerythritol and sorbitol. In general, the molecular weight of the alcohols should be less than about 1000. Mixtures of alcohols can likewise be used.
Glycerin is the preferred adjuvant because it has the attributes of a medicament, cosmetic or therapeutic agent. When glycerin is used and the hydrophilic agent is starch-based, it is believed that glycerin coats the hydrophilic agent to form a starch glycerite. When fluid is absorbed by the foam, glycerin is released, thereby allowing the hydrophilic agent to swell as it absorbs fluid from the wound and causing the foam to conform to the wound contour.
Various additional medicaments, cosmetics and therapeutic agents may be carried with the adjuvant and released with it to the desired situs. This release thus allows the transmission of such therapeutic or other agents carried in the adjuvant to the area of application outside the foam composition, further assisting in the beneficial treatment of the wound.
Illustrative of therapeutic agents which may be incorporated into the foam composition are Collasol 2400, Crotein SPA, Cromoist HYA, Crotein CAA and hydrocortisone acetate. Illustrative of cosmetic agents which may be incorporated into the foam composition are European Collagen Complex, Capture Complex Liposomes, Sardo® bath oil, a hand lotion sold under the trademark Jergens®, Noxema® skin cream, Oil of Olay® BF, Keri® lotion, Vaseline® herbal and aloe lotion, Ben Gay® ointment and Retin-A® cream.
The amount of adjuvant included in the reactant composition should preferably be sufficient to impart softness and pliability to the foam composition and be capable of delivering a therapeutic agent or the like, if included, to the environment of application. However, the volume of adjuvant should not be so great as to weaken or gel the composition. Generally, it has been found that the amount of adjuvant in the reactant composition should be from about 5 wt. % to about 30 wt. % of the reactant composition.
A wetting agent is included in the reactant composition to provide more uniform wettability of the resulting foam. The wetting agent also aids in controlling the cell size of the foam and in the reticulation of the final foam. Wetting agents suitable for use include non-ionic surfactants. Examples of materials that may be used as the wetting agent, either alone or in admixture, include block copolymers of ethylene oxide and propylene oxide sold under the trademark PLURONIC by BASF Wyandotte corporation, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, and silicone fluids. PLURONIC F-68 and L-62 are preferred. As is known, PLURONIC F-68 aids in wound cleansing without causing tissue damage. The use of PLURONIC F-68 is especially preferred because of its cleansing action, particularly because a portion of the surfactant may be released when the foam composition is exposed to the exudate of the wound. Generally, the amount of wetting agent should be from about 1% to about 10% by weight of the reactant composition, preferably from about 5% to about 7% by weight.
The wetting agent should not react with the foam composition or any component of the foam formulation to create difficulties during foam formation or to adversely affect the desired characteristics of the foam composition in use or while being stored.
It should be appreciated that the source of the water required for the foaming reaction is not critical. The water so required may be provided as a separate component of the reactant composition, or, for example, it may be provided by one of the other components of the reactant composition. By way of illustration, and not in limitation, the required water may be provided with an aqueous-based cosmetic which may be incorporated into the foam composition.
The type of water used is likewise not critical. However, for medical applications, purified water such as deionized or distilled water may be used. Saline solutions may also be used satisfactorily.
It will be appreciated that the relative proportion of prepolymer, adjuvant and hydrophilic agent included in the reactant composition can be varied over wide ranges in order to prepare a hydrophilic foam composition having the desired release and exchange characteristics previously described, while likewise providing a foam composition that is aesthetically satisfactory, insofar as its oilyness, touch, appearance and general feel. In general, for use as a wound dressing, it is preferable that the foam composition be soft and generally smooth to the touch so that it does not irritate the skin. These characteristics may be achieved by properly balancing the relative proportion of adjuvant, prepolymer hydrophilic agent wetting agent and water.
By way of illustration, it has been found that if excess glycerin is used in the reactant composition the resulting foam composition has an extended cure time with decreased ability to tightly hold external liquid and it may have an oily or spongy nonuniform surface. On the other hand, if insufficient glycerin is included in the reactant composition, the resulting foam composition has been found to be less uniform, has relatively poor flow and porosity characteristics, has relatively poor dimensional stability, and absorbs liquid at a slower rate.
Similarly, if the relative proportion of prepolymer to hydrophilic agent is too high or too low, the resulting product will not be satisfactory. The amount of hydrophilic agent must be sufficient to absorb the external liquid and to promote the release of the adjuvant. If the amount of hydrophilic agent is too low, there is insufficient absorption of external liquid. On the other hand, if the amount of hydrophilic agent is too high, then the viscosity of the reactant composition will be too high for appropriate mixing.
In general, in order for the foam composition to have the desired liquid release and exchange characteristics and to provide a foam composition that is soft to the touch and not oily, the weight ratio of prepolymer to hydrophilic agent will desirably be in the range of from about 20:1 to about 20:10 and the ratio of prepolymer to adjuvant will desirably be in the range of from about 20:2 to about 20:30.
It will likewise be appreciated that the wetting agent employed and the amount thereof used may effect the characteristics of the resulting foam composition. It is generally desired that the wetting agent be used in an amount such that the foam is substantially uniform and readily wettable.
To effect foaming and the preparation of the hydrophilic polyurethane foam composition of the present invention it is preferred to prepare and mix an organic phase and an aqueous phase. The organic phase comprises the isocyanate-capped prepolymer and optionally, but preferably, the hydrophilic agent. The aqueous phase comprises the adjuvant, wetting agent, optionally the hydrophilic agent if it is not included in the organic phase, and other desired additives, such as, for example, dyes or the like to color the resulting foam. If a medicament, cosmetic or therapeutic agent is included in the reactant composition it will preferably be included in the aqueous phase. To prepare the foam, the organic phase and aqueous phase are simply mixed at room temperature, the resulting mixture is then cast or extruded, and the foam will form.
To prepare the foam for subsequent use in a wound dressing or the like the following process is preferred. A suitable substrate, such as a plastic (e.g. in the form of a sheet, laminate or fibrous mat), paper, foil, or the like is provided and coated with a medically acceptable adhesive. Such adhesives are generally well known to those skilled in the art. Then the reactant composition as described herein is poured directly onto the adhesive where the foam is formed. The foam may then be covered by a cover sheet if desired. The resulting composite which comprises the substrate, adhesive, and foam may be die cut and later used itself, or it may be used as part of an occlusive or semi-occlusive wound dressing.
The following examples will aid in demonstrating the present invention.
In all of the examples which follow a hydrophilic polyurethane foam composition was formulated by separately preparing an aqueous phase and an organic phase then mixing both phases at room temperature, and casting the mixture onto a film substrate.
The aqueous phase was prepared by dissolving the alcohol, wetting agent and colorant in distilled water using a laboratory grade magnetic stirrer. It should be noted that some surfactants (especially the paste types) required heating to 150° F. before dissolution or even dispersion was possible. All other mixing was done at ambient temperature. When Pluronic F-68 was used, solution required about one hour of mixing at 1000 rpm on the stirrer to complete dissolution.
The organic phase was prepared by mixing the isocyanate-capped prepolymer and hydrophilic agent for about 5 to 10 seconds in a plastic vessel using an electric drill with a paint mixer blade.
To prepare the foam composition, the aqueous phase was poured into the organic phase contained in a suitable mixing vessel. The two phases were then mixed using a drill with the paint mixer for about 15 to about 50 seconds at about 1200 rpm of the drill. Mixing time may be varied for different formulations, but generally mixing time was about 25 seconds.
The resulting mixture was evenly poured as a bead down a paper substrate coated with a medical grade adhesive, and covered with the silicone treated side of a 5 mil polystyrene sheet. The paper substrate was about four inches wide and bordered by 0.025 inch plastic strips to contain the mixture during compression. The bead was compressed and spread using a 30 pound steel cylinder. The mixture was rolled at the rate of two inches per second first at 90 seconds after the two phases are combined and then after 120 seconds after combination. The foam was allowed to set for approximately seven minutes, then the cover sheet was removed.
The resulting foams varied in thickness from about 0.050 inch to about 0.10 inch and varied in density from about 10 to about 20 lbs/ft3.
As used in the Examples appearing below, the following designations, symbols, terms and abbreviations have the indicated meanings:
______________________________________
I. Prepolymers:
Prepolymer A
denotes an isocyanate-capped
polyoxyethylene polyol
polyurethane prepolymer derived
from toluene diisocyanate having
an equivalent weight (per-NCO
group) of 625, an NCO content of
1.6 meq/gram, a functionality
(--NCO/mole) of 2.3 and a
viscosity at 25° C. of 20,000
cps. (HYPOL 2002)
Prepolymer B
denotes an isocyanate-capped
polyoxyethylene polyol
polyurethane prepolymer derived
from toluene diisocyanate having
an NCO content of 0.5-0.9 meq/g.
and a viscosity at 25° C. of 10,000
to 12,000 cps. (HYPOL HYDROGEL)
Prepolymer C
denotes an isocyanate-capped
polyoxyethylene polyol
polyurethane prepolymer derived
from isophorone diisocyanate
having an NCO content of 1.8
meq/gram and a viscosity at 25° C.
of 12,000 cps. (HYPOL X6100)
Prepolymer D
denotes an isocyanate-capped
polyoxyethylene polyol
polyurethane prepolymer derived
from toluene diisocyanate having
an --NCO content of 1.4 meq/gram
and a viscosity at 90° C. of 4,700
cps. (TREPOL)
Prepolymer E
denotes an isocyanate-capped
polyoxyethylene polyol
polyurethane prepolymer derived
from methylenediphenyl
diisocyanate having an NCO
content of 2.55 meq/g, an
equivalent weight (per-NCO group)
of 392 and a viscosity at 25° C. of
18,000 cps. (HYPOL FHP 5000)
Prepolymer F
denotes an isocyanate-capped
polyoxyethylene polyol
polyurethane prepolymer derived
from methylenediphenyl
diisocyanate having an equivalent
weight (per-NCO group) of 476, an
--NCO content of 2.10 meq/g and a
viscosity at 25° C. of 20,000
cps. (HYPOL FHP 4000)
Prepolymer G
denotes a diisocyanate prepolymer
derived from toluene diisocyanate
sold under the trademark AQUAPOL
035-0019 by Freeman Chemical
Corporation.
II. Hydrophilic agents:
A denotes a starch-g-poly(2-propenamide-co-2-
propenoic acid, mixed sodium and aluminum
salt) sold under the trademark WATER LOCK
superabsorbent polymer A-222.
B denotes a starch-g-poly(2-propenamide-co-2-
propenoic acid, sodium salt) sold under the
trademark WATER LOCK superabsorbent
polymer A-200.
C denotes a starch-g-poly(2-propenamide-co-2-
propenoic acid, sodium salt) sold under the
trademark WATER LOCK superabsorbent
polymer A-100.
D denotes a polymer consisting of 2-propenoic
acid, sodium salt sold under the trademark
WATER LOCK superabsorbent polymer J-500.
E denotes an absorbent polymer sold under the
trademark ARASORB.
F denotes a polyacrylic acid, sodium salt sold
under the trademark AQUA KEEP J-500.
III. Absorption and Extraction Test:
Each of the foams of Examples 1-57 was tested to determine the
release characteristics of the foam, especially the adjuvant, and
to determine the ability of the foam to absorb external liquid.
The foams were immersed in one or more of the following:
water, a normal saline solution, a 0.03% HCl solution and/or a
0.05% NaOH solution. The pH of these solutions fall within the
range of pH 2 to pH 12. Both the liquid held by the sample and
the liquid tightly held by the sample were measured.
The liquid held by the sample is reported as retained liquid.
Retained liquid is the unit weight of liquid per unit weight of
foam. It is determined by the formula:
##STR1##
______________________________________
Tightly held liquid is a measure of the relative amount of liquid retained by the sample after compression. It is determined by rolling an 8 pound roller over the sample ten times, and then, using the retained liquid formula to calculate the relative proportion of liquid that was not squeezed out of the composition.
To determine whether the adjuvant is efficiently released from the foam, the % extractables is measured in deionized water, normal saline, 0.03%HCl and/or 0.05%NaOH solutions. The percent extractable material is determined under static conditions at room temperature. In addition, the dehydrated extracted residues were visually examined for the adjuvant. In general, it was found that from about 90 to 95% of the adjuvant is released from the foam In general, when deionized water was used, the pH of the extract was 7.0±1.0 pH units.
The absorption rate was determined for the foam compositions. The absorption rate is the time, in seconds, for 0.1 g of fluid to be absorbed by the foam composition. The fluid used was either deionized water, distilled water or normal saline. An absorption rate of less than 10 is satisfactory, and a rate of less than 5 is preferred.
The data for these studies is set forth in Tables immediately following the Examples.
Unless otherwise noted, for the compositions set forth in the Tables hereinafter all parts are in part by weight.
These Examples illustrate reactant compositions used to make hydrophilic foams of the present invention. Examples 1-8 illustrate variations in the amount of water and in the wetting agent used in the reactant composition. Example 8 illustrates the wide range of the ratio of prepolymer to hydrophilic agent and prepolymer to adjuvant that can be employed in making the foam composition of this invention. The reactant compositions are set forth in Table I below.
The retained liquid, tightly held liquid, extractable materials and absorption rate for the foam compositions of Examples 1 through 8 are set forth in Table II.
TABLE I
__________________________________________________________________________
EXAMPLE No.
REACTANT COMPOSITION
1 2 3 4 5 6 7 8
__________________________________________________________________________
I. PREPOLYMER 20.00
20.00
20.00
20.00
20.00
20.00
20.00
9.00
Prepolymer A
II.
HYDROPHILIC AGENT
2.00
2.00
2.00
2.00
2.00
2.00
2.00
3.00
A
III.
WATER 14.50
10.00
14.50
10.00
12.25
15.00
13.00
18.00
IV.
ADJUVANT SYSTEM 5.00
5.00
5.00
5.00
5.00
5.00
5.00
15.00
glycerin
V. WETTING AGENT
Pluronic F-68 2.50 1.25
Pluronic L-62 1.00 0.50 0.70
Pluronic F-88 2.50
Pluronic L-92 1.00
TMAZ 85 sorbitan 2.00
trioleate
Mazol 80 MG-K 2.00
VI.
DYES/DEFOAMING AGENTS
FD & C Blue 0.05
0.05 0.025
No. 1 Solution
FD & C Red 0.025
No. 3 & 40 Solution
__________________________________________________________________________
TABLE II
__________________________________________________________________________
EXAMPLE NO.
RETAINED LIQUID
1 2 3 4 5 6 7 8
__________________________________________________________________________
Water 5.4
5.3
6.1
6.4
5.6
6.2
5.9
7.1
Tightly Held Water
3.3
2.9
2.8
3.3
3.0
3.4
3.0
4.9
% Extractable Material
22.0
19.0
21.0
20.0
20.0
16.0
18.0
46.0
Saline 3.9
3.6
-- -- 3.6
4.4
-- --
Tightly Held Saline
1.3
1.4
-- -- 1.4
1.4
-- --
% Extractable Material
22.5
19.6
-- -- 19.0
16.0
-- --
0.03% HCl Solution
4.0
3.6
3.8
4.0
3.3
-- -- --
Tightly Held 0.03% HCl
0.92
0.97
0.89
0.87
0.95
-- -- --
Solution
% Extractable Material
22.7
18.6
23.0
22.0
20.0
-- -- --
0.05% NaOH 5.2
4.9
5.1
5.8
4.7
-- -- --
Tightly Held 0.05% NaOH
2.6
2.4
2.3
2.8
2.4
-- -- --
% Extractable Material
21.2
18.2
22.0
19.2
19.0
-- -- --
ABSORPTION RATE
3.0
3.0
2.0
3.5
1.0
6.0
1.0
2.5
__________________________________________________________________________
As can be seen by the data in Tables I and II, all of the foams were satisfactory according to the desired physical and chemical criteria. The foams of Examples 1 and 2 are preferred.
These Examples illustrate reactant compositions suitable for preparing hydrophilic foam compositions of the present invention wherein various adjuvants and combinations of adjuvants are used. The reactant compositions are set forth in Table III.
The retained liquid, tightly held liquid, extractable materials and absorption rate for the foam compositions of Examples 9 through 18 are set forth in Table IV.
TABLE III
__________________________________________________________________________
EXAMPLE No.
REACTANT COMPOSITION
9 10 11 12 13 14 15 16 17 18
__________________________________________________________________________
I. PREPOLYMER 20.00
20.00
20.00
20.00
20.00
20.00
20.00
20.00
20.00
20.00
Prepolymer A
II.
HYDROPHILIC AGENT
2.00
2.00
2.00
2.00
2.00
2.00
2.00
2.00
2.00
2.00
A
III.
WATER 14.50
14.50
14.50
14.50
14.50
14.50
14.50
14.50
14.50
14.50
IV.
ADJUVANT SYSTEM
1,2,4-butanetriol
5.00
trimethylol propane
5.00
glycerin 4.00
2.50 2.50
4.00
4.50
polypropylene glycol 500
1.00 5.00 2.50
1.00
propylene glycol 2.50
5.00
ethyl alcohol 5.00
penetaerythritol 0.50
V. WETTING AGENT
2.50
2.50
2.50
2.50
2.50
2.50
2.50
2.50
2.50
2.50
Pluronic F-68
VI.
OTHER 0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
FD & C Blue
No. 1 Solution
__________________________________________________________________________
TABLE IV
__________________________________________________________________________
EXAMPLE NO.
RETAINED LIQUID
9 10 11 12 13 14 15 16 17 18
__________________________________________________________________________
Water 4.7
5.9
4.4
5.9
5.1
4.7
7.6
3.8
4.4
6.6
Tightly Held Water
2.8
3.6
2.8
2.9
3.0
4.3
4.8
3.3
2.8
2.8
% Extractable Material
23.0
19.0
22.2
17.0
17.5
19.0
11.1
15.0
22.2
21.0
Saline 3.4
3.4
3.4
-- 3.7
2.9
3.9
3.0
3.4
--
Tightly Held Saline
1.3
1.5
1.5
-- 1.5
2.4
2.2
1.9
1.5
--
% Extractable Material
22.0
18.0
19.6
-- 17.4
16.5
7.2
14.0
19.6
--
ABSORPTION RATE
5.5
4.5
4.5
2.0
2.0
>60
2.5
>60
4.5
2.0
__________________________________________________________________________
The foams of Examples 9-12, 17 and 18 were acceptable. However, the foams of Examples 13 and 15 exhibited gross porosity, while the foams of Examples 14 and 16 had excessively high absorption rates, and were thus more hydrophobic.
These Examples illustrate reactant compositions suitable for preparing hydrophilic foam compositions of the present invention wherein various prepolymers and mixtures of prepolymers are used in the reactant composition. The reactant compositions are set forth in Table V.
The retained liquid, tightly held liquid, extractable materials and absorption rate for the foam compositions of Examples 19 through 26 are set forth in Table VI.
TABLE V
__________________________________________________________________________
EXAMPLE No.
REACTANT COMPOSITION
19 20 21 22 23 24 25 26
__________________________________________________________________________
I. PREPOLYMER
Prepolymer A 15.00
Prepolymer B 20.00 5.00 10.00 10.00
Prepolymer C 10.00
Prepolymer D 20.00
10.00
Prepolymer E 20.00
Prepolymer F 20.00
Prepolymer G 20.00
II.
HYDROPHILIC AGENT
A 2.00
2.00
2.00
2.00
2.00
2.00
2.00
2.50
D 2.00 0.50
III.
WATER 14.50
14.50
14.50
10.00
14.50
14.50
14.50
Normal saline, 14.50
0.85% NaCl
IV.
ADJUVANT SYSTEM
glycerin 5.00
5.00
5.00
5.00
5.00
10.00
5.00
10.00
honey 0.50 0.50
V. WETTING AGENT
Pluronic F-68
2.50
2.50
2.50 2.50
2.50
2.50
2.50
Pluronic L-92 1.00
VI.
OTHER 0.05
0.05
0.05 0.05
0.05
0.05
0.05
FD & C Blue
No. 1 Solution
__________________________________________________________________________
TABLE VI
__________________________________________________________________________
EXAMPLE NO.
RETAINED LIQUID
19 20 21 22 23 24 25 26
__________________________________________________________________________
Water 7.1
5.4
5.9
3.1
3.8
8.5
7.9
10.0
Tightly Held Water
5.9
4.9
2.0
2.5
2.2
6.0
4.8
6.6
% Extractable Material
20.2
16.0
21.2
18.0
21.0
30.0
21.0
24.2
Saline 5.8
4.0
-- -- -- -- -- --
Tightly Held Saline
4.5
3.6
-- -- -- -- -- --
% Extractable Material
16.2
12.4
-- -- -- -- -- --
ABSORPTION RATE
4.0
>60
3.0
1.0
1.0
75 2.5
2.5
__________________________________________________________________________
The foams of Examples 21 and 26 were acceptable as determined by all visual and measured properties. However, the foams of Examples 19 and 20 exhibit relatively poorer dimensional stability and a slower absorption rate. The foams of Examples 22-25 were less uniform than the preferred composition of Examples 1 and 2.
These Examples illustrate the wide variety of hydrophilic agents that may be suitably employed in the reactant composition used to prepare the hydrophilic foam compositions of the present invention. The reactant compositions are set forth in Table VII.
The retained liquid, tightly held liquid, extractable materials and absorption rate for the foam compositions of these Examples are set forth in Table VIII.
TABLE VII
______________________________________
EXAMPLE No.
REACTANT
COMPOSITION 27 28 29 30 31 32
______________________________________
I. PREPOLYMER 20.00 20.00
20.00
20.00
20.00
20.00
Prepolymer A
II. HYDROPHILIC
AGENT
D 2.00
C 4.00
E 2.00
Carrageenan 2.00
A 2.00 2.00
poly D-glucosamine 1.00
pectin 2.00
III. WATER 14.50 14.50
10.00
10.00
14.50
10.00
IV. ADJUVANT 5.00 5.00 5.00 5.00 5.00 5.00
SYSTEM
glycerin
V. WETTING
AGENT
Pluronic F-68 2.50 2.50 1.10 2.50 2.50
Pluronic L-62 1.00
VI. OTHER
FD & C Blue 0.05 0.05 0.05
No. 1 Solution
FD & C Red 0.05 0.05 0.05
No. 2 & 40 Solution
10% Dimethylpoly- 0.10
siloxane
______________________________________
TABLE VIII
______________________________________
EXAMPLE NO.
RETAINED LIQUID 27 28 29 30 31 32
______________________________________
Water 8.2 9.4 4.7 8.8 5.3 7.5
Tightly Held Water
6.6 6.0 0.92 4.5 2.8 2.5
% Extractable Material
20.7 20.7 -- -- 22.0 --
Saline -- -- -- -- 3.9 --
Tightly Held Saline
-- -- -- -- 1.3 --
% Extractable Material
-- -- -- -- 21.0 --
ABSORPTION RATE 2.0 1.0 2.0 3.5 2.0 4.5
______________________________________
The foams of Examples 27-32 were all acceptable by all criteria. However, the tightly held liquid of Example 29 is somewhat low.
These Examples illustrate the addition of therapeutic agents suitable for use in wound dressing applications to the adjuvant of the reactant composition used to prepare hydrophilic foam compositions of the present invention. The reactant compositions are set forth in Table IX.
The retained liquid, tightly held liquid, extractable materials and absorption rate for the foam compositions of these Examples are set forth in Table X.
TABLE IX
______________________________________
EXAMPLE No.
REACTANT COMPOSITION
33 34 35 36 37
______________________________________
I. PREPOLYMER 20.00 20.00
20.00
20.00
20.00
Prepolymer A
II. HYDROPHILIC AGENT
2.00 2.00 2.00 2.00 2.00
A
III. WATER 14.50 14.50
14.50
14.50
14.50
IV. ADJUVANT SYSTEM
glycerin 5.00 5.00 5.00 5.00 5.00
Collasol 2400 2.00
Crotein SPA 2.00
Cromoist HYA 2.00
Crotein CAA 2.00
Hydrocortisone 2.00
acetate, 0.5%
V. WETTING AGENT 2.50 2.50 2.50 2.50 2.50
Pluronic F-68
VI. OTHER 0.05 0.05 0.05 0.05 0.05
FD & C Blue
No. 1 Solution
______________________________________
TABLE X
______________________________________
EXAMPLE NO.
RETAINED LIQUID
33 34 35 36 37
______________________________________
Water 5.6 6.8 6.4 5.7 6.6
Tightly Held Water
2.6 2.7 2.8 2.3 2.7
% Extractable Material
23.0 24.0 20.0 29.0 21.0
ABSORPTION RATE
2.0 2.0 3.0 2.0 4.0
______________________________________
As can be seen by the data, all the foams of Examples 33-37 were acceptable.
These Examples illustrate the addition of cosmetic agents suitable for use in the hydrophilic foam compositions of the present invention. The reactant compositions are set forth in Table XI.
In Examples 43-47 the water needed for the foaming reaction was provided by the water contained by the cosmetic. The surfactant was also included in the cosmetic.
The retained liquid, tightly held liquid, extractable materials and absorption rate for the foam compositions of these Examples are set forth in Table XII.
TABLE XI
__________________________________________________________________________
EXAMPLE No.
REACTANT COMPOSITION
38 39 40 41 42 43 44 45 46 47
__________________________________________________________________________
I. PREPOLYMER 20.00
20.00
20.00
20.00
20.00
20.00
20.00
20.00
20.00
10.00
Prepolymer A
II.
HYDROPHILIC AGENT
2.00
2.00
2.00
2.00
2.00
2.00
2.00
2.00
2.00
1.00
A
III.
WATER 14.50
14.50
14.50
14.50
14.50
-- -- -- -- --
IV.
ADJUVANT SYSTEM
glycerin 2.50
4.00
5.00
5.00
5.00
5.00
5.00
5.00
5.00
2.50
European Collagen
2.50
Complex
Capture Complex 1.00
Liposomes
Sardo bath oil 2.00
Jergens lotion 2.00
Noxema skin cream 2.00
Oil of Olay BF 20.00
Keri lotion 20.00
Vaseline Herbal & 20.00
Aloe lotion
Ben Gay ointment 20.00
Retin-A cream 10.00
V. WETTING AGENT
2.50
2.50
2.50
2.50
2.50
-- -- -- --
Pluronic F-68
VI.
OTHER 0.05
0.05
0.05
0.05
0.05
-- -- -- --
FD & C Blue
No. 1 Solution
__________________________________________________________________________
TABLE XII
__________________________________________________________________________
EXAMPLE NO.
RETAINED LIQUID
38 39 40 41 42 43 44 45 46 47
__________________________________________________________________________
Water 5.2
5.3
6.1
6.7
6.2
6.2
6.3
5.9
6.5
6.0
Tightly Held Water
3.0
2.9
2.8
3.0
2.8
3.0
2.9
3.2
3.3
3.0
% Extractable Material
15.0
19.0
22.0
22.0
25.0
14.0
24.2
16.0
22.0
15.0
ABSORPTION RATE
8.5
3.0
2.0
16 2.5
7.0
5.0
7.5
6.5
30
__________________________________________________________________________
The foams of Examples 41 and 47 were less hydrophilic than desired as can be seen by their high absorption rates. The foams of all the other Examples were satisfactory. The foams of Examples 43-46 were especially soft and uniform with distinct cosmetic odor.
These Examples illustrate the wide variety of combinations of isocyanate prepolymer, hydrophilic agent, adjuvant and wetting agent that may be used to form a hydrophilic foam composition in accordance with the present invention. The composition of the reactant compositions used are set forth in Table XIII.
The retained liquid, tightly held liquid, extractable materials and absorption rate for the foam compositions of these Examples are set forth in Table XIV.
TABLE XIII
__________________________________________________________________________
EXAMPLE No.
REACTANT COMPOSITION
48 49 50 51 52 53 54 55 56 57
__________________________________________________________________________
I. PREPOLYMER
Prepolymer A 20.00
20.00
10.00
10.00
20.00
15.00
10.00
10.00
10.00
10.00
Prepolymer B 10.00
10.00 5.00
10.00
10.00
10.00
10.00
II.
HYDROPHILIC AGENT
A 2.00
2.00
2.00
2.00
4.00
2.00
2.00
2.00
2.00
2.00
D 1.00
1.00
1.00
2.00
2.00
2.00
2.00
2.00
2.00
III.
WATER 14.50
14.50
14.50
14.50
14.50
14.50
12.00
23.00
14.50
Normal saline 14.50
(0.85% NaCl)
IV.
ADJUVANT SYSTEM
glycerin 5.00
5.00
5.00
15.00
10.00
9.00
13.00
10.00
10.00
10.00
Honey 1.00
1.00
3.00
1.00
1.00
1.00
0.50
0.50
0.15
propylene glycol
1.00
2.00
V. WETTING AGENT
Pluronic F-68
2.50
2.50
2.50
2.50
2.50
2.50
2.00
4.00
2.50
2.50
Pluronic L-62 1.00
Crodesta SL-40 1.00
VI.
OTHER 0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
0.05
FD & C Blue
No. 1 Solution
__________________________________________________________________________
TABLE XIV
__________________________________________________________________________
EXAMPLE NO.
RETAINED LIQUID
48 49 50 51 52
53 54 55 56 57
__________________________________________________________________________
Water 5.1
6.5
6.3
6.9
--
11.1
12.2
8.5
11.6
12.2
Tightly Held Water
2.6
4.1
4.6
5.0
--
6.3
6.7
6.0
8.1
6.3
% Extractable Material
25.0
17.0
24.0
29.3
--
29.0
26.3
30.0
26.8
28.0
ABSORPTION RATE
2.0
1.5
2.0
2.0
1.0
1.5
2.0
9.0
1.0
1.0
__________________________________________________________________________
The foams of Examples 48, 50, 56 and 57 were acceptable. The foams of Examples 51 through 54 were more porous than desired, although the liquid retention and extractability were good. The amount of extractable material for the foam of Example 49 was somewhat low.
Claims (40)
1. A hydrophilic foam composition comprising the in situ reaction product of: a) an isocyanate-capped polyether prepolymer, b) a polymeric hydrophilic agent capable of absorbing water, c) an adjuvant comprising an alcohol selected from the group consisting of water soluble monols, diols and polyhydric alcohols, d) a wetting agent, and e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.
2. The hydrophilic foam composition of claim 1 wherein said prepolymer is a member selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 3.0 meq/g and mixtures thereof.
3. The hydrophilic foam composition of claim 1 wherein said prepolymer is present in an amount of from about 20 wt. % to about 60 wt. % of the total reactant composition.
4. The hydrophilic foam composition of claim 1 wherein said prepolymer is present in an amount of from about 45 to about 50 wt. % of the total reactant composition.
5. The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is an absorptive polymer capable of absorbing water and having a fluid uptake of at least about 50 ml of water per gram of said polymer.
6. The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is an absorptive polymer having a fluid uptake of at least about 100 ml of water per gram of said polymer.
7. The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is an absorptive polymer having a fluid uptake of at least about 150 ml of water per gram of said polymer.
8. The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts, and mixtures thereof.
9. The hydrophilic foam composition of claim 1 wherein said hydrophilic agent is present in an amount sufficient to provide a foam composition capable of absorbing at least about 3 times its weight of liquid.
10. The hydrophilic foam composition of claim 8 wherein said hydrophilic agent is present in an amount sufficient to provide a foam composition capable of absorbing at least about 3 times its weight of liquid.
11. The hydrophilic foam composition of claim 9 wherein said foam composition is capable of tightly carrying at least about 3 times its weight of liquid.
12. The hydrophilic foam composition of claim 10 wherein said foam composition is capable of tightly carrying at least about 3 times its weight of liquid.
13. The hydrophilic foam composition of claim 1 wherein said alcohol is a monol.
14. The hydrophilic foam composition of claim 1 wherein said alcohol is a diol.
15. The hydrophilic foam composition of claim 1 wherein said alcohol is a polyhydric alcohol.
16. The hydrophilic foam composition of claim 15 wherein said polyhydric alcohol has a molecular weight of less than about 1000.
17. The hydrophilic foam composition of claim 1 wherein said alcohol is a member selected from the group consisting of isopropyl alcohol, ethanol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof.
18. The hydrophilic foam composition of claim 10 wherein said alcohol is glycerin.
19. The hydrophilic foam composition of claim 1 wherein said alcohol is present in an amount of from about 5% to about 30% by weight of the reactant composition.
20. The hydrophilic foam composition of claim 1 wherein said wetting agent is a non-ionic surfactant selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof.
21. The hydrophilic foam composition of claim 20 wherein said wetting agent is present in an amount of from about 1% to about 10% by weight of said reactant composition.
22. The hydrophilic foam composition of claim 1 wherein said prepolymer, said hydrophilic agent and said adjuvant are present in the reactant composition such that the ratio of prepolymer to hydrophilic agent is in the range of from about 20:1 to about 20:10 and the ratio of prepolymer to adjuvant is in the range of from about 20:2 to about 20:30.
23. A hydrophilic foam composition comprising the in situ reaction product of : a) an isocyanate-capped polyether prepolymer, wherein said prepolymer is a member selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 3.0 meq/g, b) a hydrophilic agent capable of absorbing water, said hydrophilic agent being a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts and mixtures thereof; c) an adjuvant comprising an alcohol, said adjuvant being a member selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4- butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof; said reactant composition (d) including a wetting agent selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof, and e) water, said water being a member selected from the group consisting of deionized water, distilled water and normal saline.
24. The hydrophilic foam composition of claim 23 wherein said prepolymer is an isocyanate-capped polyether prepolymer having an isocyanate equivalent weight of about 1.6 meq/g and an equivalent weight per isocyanato group of about 625; said hydrophilic agent is starch-g-poly(2-propenamide-co-2-propenoic acid, mixed sodium and aluminum salt); said adjuvant comprises glycerine, and said wetting agent is a member selected from the group consisting of block copolymers of ethylene oxide and propylene oxide.
25. A wound dressing comprising the in situ reaction product of: a) an isocyanate-capped polyether prepolymer, b) a polymeric hydrophilic agent capable of absorbing water, c) an adjuvant comprising an alcohol selected from the group consisting of water soluble monols, diols and polyhydric alcohols, d) a wetting agent, and e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.
26. A wound dressing composition comprising the in situ reaction product of: a) an isocyanate-capped polyether prepolymer selected from the group consisting of isocyanate-capped polyether polyols having an isocyanate equivalent weight of from about 0.5 meq/g to about 7.5 meq/g, b) a hydrophilic agent capable of absorbing water selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts, and mixtures thereof, c) an adjuvant comprising an alcohol selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, sorbitol, pentaerythritol, and mixtures thereof, d) a wetting agent selected from the group consisting of block copolymers of ethylene oxide and propyleneoxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids, and mixtures thereof, and e) water selected from the group consisting of deionized water, distilled water, and normal saline, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released in the presence of the external liquid.
27. A wound dressing comprising a hydrophilic foam composition comprising the in situ reaction product of
(a) an isocyanate-capped polyether prepolymer having an isocyanate equivalent weight of from about 0.5 meq/g to about 3 meq/g;
(b) a hydrophilic agent capable of absorbing water and having a fluid uptake of at least about 50 ml of water per gram of said agent, and wherein said hydrophilic agent comprises a hydrophilic material which is a member selected from the group consisting of starch grafted copolymers of acrylate salts, starch grafted copolymers of acrylamide salts, polyacrylate salts and mixtures thereof;
(c) an adjuvant comprising an alcohol selected from the group consisting of ethanol, isopropyl alcohol, propylene glycol, polyethylene glycol, polypropylene glycol, glycerine, 1,2,4-butanetriol, trimethylolpropane, pentaerythritol sorbitol, and mixtures thereof;
(d) a wetting agent comprising a non-ionic surfactant selected from the group consisting of block copolymers of ethylene oxide and propylene oxide, ethoxylated sorbitan fatty acid esters, glycerol esters, polyglycerol esters, silicone fluids and mixtures thereof; and
(e) water, said hydrophilic foam composition releasably carrying said adjuvant so that said foam composition is capable of absorbing an external liquid and tightly carrying said liquid in preference to at least a portion of said adjuvant so that said adjuvant is released from said foam composition in the presence of the external liquid.
28. The wound dressing of claim 27 wherein said water is selected from the group consisting of deionized water, distilled water and normal saline.
29. The wound dressing of claim 25 wherein said hydrophilic agent comprises an additive selected from the group consisting of methylcellulose, guar gum, pectin, karaya gum, chitosan, agar, acacia powder, carrageenan, gelatin, and mixtures thereof.
30. The wound dressing of claim 25 wherein said adjuvant comprises a therapeutic agent.
31. The wound dressing of claim 25 wherein said adjuvant comprises a medicament.
32. The wound dressing of claim 25 wherein said adjuvant comprises a cosmetic.
33. The wound dressing of claim 30 wherein said therapeutic agent is selected from the group consisting of soluble collagen, hydrolyzed collagen, collagen amino acids salt free, hydrolyzed animal protein and hyaluronic acid, an ointment including methyl salicylate and menthol and hydrocortisone acetate.
34. The wound dressing of claim 32 wherein said cosmetic is selected from the group consisting of collagen complex, liposomes, bath oil, a lotion, a cream, a herbal and aloe lotion, an ointment and tretinoin cream.
35. The wound dressing of claim 27 wherein said isocyanate-capped polyether prepolymer has an isocyanate equivalent weight of about 1.6 meq/g and an equivalent weight per isocyanato group of about 625; said hydrophilic agent is starch-g-poly(2-propenamide-co-2-propenoic acid, mixed sodium and aluminum salt), said adjuvant comprises glycerin, said wetting agent is a member selected from the group consisting of block copolymers of ethylene oxide and propylene oxide.
36. The wound dressing of claim 35 wherein said prepolymer, said hydrophilic agent and said adjuvant are present in the reactant composition such that the ratio of prepolymer o hydrophilic agent is in the range of from about 20:1 to about 20:10 and the ratio of prepolymer to adjuvant is in the range of from about 20:2 to about 20:30.
37. A method for treating a wound comprising applying to the wound a wound dressing as claimed in claim 25.
38. A method for treating a wound comprising applying to the wound a wound dressing as claimed in claim 27.
39. A method for treating a wound comprising applying to the wound a wound dressing as claimed in claim 35.
40. The hydrophilic foam composition of claim 23 wherein said prepolymer, said hydrophilic agent and said adjuvant are present in the reactant composition such that the ratio of prepolymer to hydrophilic agent is in the range of from about 20:1 to about 20:10 and the ratio of prepolymer to adjuvant is in the range of from about 20:2 about 20:30.
Priority Applications (12)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/175,036 US5064653A (en) | 1988-03-29 | 1988-03-29 | Hydrophilic foam compositions |
| ES89303064T ES2057111T3 (en) | 1988-03-29 | 1989-03-28 | HYDROPHILIC FOAM COMPOSITIONS. |
| DE89303064T DE68907362T2 (en) | 1988-03-29 | 1989-03-28 | Hydrophilic foam compositions. |
| AT89303064T ATE91074T1 (en) | 1988-03-29 | 1989-03-28 | HYDROPHILIC FOAM COMPOSITIONS. |
| EP89303064A EP0335669B1 (en) | 1988-03-29 | 1989-03-28 | Hydrophilic foam compositions |
| CA000594916A CA1322072C (en) | 1988-03-29 | 1989-03-28 | Hydrophilic foam compositions |
| CN89103214A CN1037523A (en) | 1988-03-29 | 1989-03-29 | Hydrophilic foam compositions |
| KR1019890004007A KR0131075B1 (en) | 1988-03-29 | 1989-03-29 | Hydrophilic foam compositions |
| JP1077972A JPH07113067B2 (en) | 1988-03-29 | 1989-03-29 | Hydrophilic foam composition |
| US07/705,938 US5065752A (en) | 1988-03-29 | 1991-05-28 | Hydrophilic foam compositions |
| US08/014,044 US5254301A (en) | 1988-03-29 | 1993-02-05 | Process for preparing a sheet of polymer-based foam |
| US08/819,397 US5916928A (en) | 1988-03-29 | 1995-06-05 | Polymer-based porous foam |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/175,036 US5064653A (en) | 1988-03-29 | 1988-03-29 | Hydrophilic foam compositions |
Related Child Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US42295489A Continuation-In-Part | 1988-03-29 | 1989-10-18 | |
| US07/705,938 Division US5065752A (en) | 1988-03-29 | 1991-05-28 | Hydrophilic foam compositions |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| US5064653A true US5064653A (en) | 1991-11-12 |
Family
ID=22638574
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| US07/175,036 Expired - Lifetime US5064653A (en) | 1988-03-29 | 1988-03-29 | Hydrophilic foam compositions |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US5064653A (en) |
| EP (1) | EP0335669B1 (en) |
| JP (1) | JPH07113067B2 (en) |
| KR (1) | KR0131075B1 (en) |
| CN (1) | CN1037523A (en) |
| AT (1) | ATE91074T1 (en) |
| CA (1) | CA1322072C (en) |
| DE (1) | DE68907362T2 (en) |
| ES (1) | ES2057111T3 (en) |
Cited By (105)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5266608A (en) * | 1990-06-29 | 1993-11-30 | Technion Research & Dev't Foundation, Ltd. | Biomedical adhesive compositions |
| DE4233289A1 (en) * | 1992-10-02 | 1994-04-07 | Beiersdorf Ag | Self adhesive polyurethane foam gel contg. water absorber - with non-aq. foaming agents, useful as plasters, wound dressings, etc., adheres to skin but not to wet wounds |
| WO1994008604A1 (en) * | 1992-10-16 | 1994-04-28 | Affinity Biotech, Inc. | Convertible microemulsion formulations |
| DE4308445A1 (en) * | 1993-03-17 | 1994-09-22 | Beiersdorf Ag | Wound dressing based on hydrophilic polyurethane gel foams and process for their production |
| DE4308347A1 (en) * | 1993-03-17 | 1994-09-29 | Beiersdorf Ag | Hydrophilic polyurethane foam gels, in particular for the treatment of deep wounds and process for their production |
| DE4328190A1 (en) * | 1993-08-23 | 1995-03-02 | Beiersdorf Ag | Wound care articles with selective absorbency |
| US5444041A (en) * | 1991-04-19 | 1995-08-22 | Ibah, Inc. | Convertible microemulsion formulations |
| US5506277A (en) * | 1994-06-30 | 1996-04-09 | Kimberly-Clark Corporation | Starch foams for absorbent articles |
| WO1996016643A1 (en) * | 1994-11-28 | 1996-06-06 | The Government Of The United States, As Represented By The Secretary Of The Army | Drug releasing surgical implant or dressing material |
| US5562914A (en) * | 1990-12-06 | 1996-10-08 | Zeneca Inc. | Impregnated porous granules and a polyurethane matrix held within the pores thereof and holding a liquid material for controlled release of liquid material and process therefor |
| US5571529A (en) * | 1991-11-07 | 1996-11-05 | Johnson & Johnson Medical, Inc. | Method of making polyurethane foam |
| US5578317A (en) * | 1995-03-31 | 1996-11-26 | Mulder; Gerit D. | Wound filler and method of manufacture |
| US5578310A (en) * | 1992-04-23 | 1996-11-26 | Berlex Laboratories Inc. | Topical bioadhesive ointment compositions and their use in wound healing |
| US5650450A (en) * | 1996-01-25 | 1997-07-22 | Foamex L.P. | Hydrophilic urethane foam |
| US5685834A (en) * | 1994-07-29 | 1997-11-11 | Barth; Alan H. | Surgical dressing material |
| US5688761A (en) * | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
| US5833665A (en) * | 1990-06-14 | 1998-11-10 | Integra Lifesciences I, Ltd. | Polyurethane-biopolymer composite |
| US5849850A (en) * | 1994-11-22 | 1998-12-15 | Imperial Chemical Industries Plc | Process for making flexible foams |
| US5916928A (en) * | 1988-03-29 | 1999-06-29 | Ferris Corporation | Polymer-based porous foam |
| US6198016B1 (en) | 1998-12-01 | 2001-03-06 | 3M Innovative Properties Company | Wet skin adhesive article |
| US6326410B1 (en) | 1992-11-04 | 2001-12-04 | Johnson & Johnson Medical, Inc. | Wound dressing comprising polyurethane foam |
| US6349828B1 (en) | 1997-02-06 | 2002-02-26 | Ferris Pharmaceuticals Inc. | Tamper evident packaging |
| US6399092B1 (en) * | 2000-12-27 | 2002-06-04 | Healthpoint, Ltd. | Anhydrous, hydrophilic absorbent wound dressing (tube) with antimicrobials or other pharmaceutically active agents |
| US6447802B2 (en) | 1998-06-08 | 2002-09-10 | Ferris Corporation | Analgesic and antinociceptive methods |
| US6528483B2 (en) | 1995-06-07 | 2003-03-04 | André Beaulieu | Method of producing concentrated non-buffered solutions of fibronectin |
| US6548727B1 (en) | 2000-02-17 | 2003-04-15 | 3M Innovative Properties Company | Foam/film composite medical articles |
| US6559353B1 (en) * | 1995-01-19 | 2003-05-06 | Christopher H. Sheridan | Treated disposable articles for reducing skin breakdown |
| US6617014B1 (en) * | 1999-09-01 | 2003-09-09 | Hydrophilix, Llc | Foam composite |
| WO2003084579A1 (en) * | 2002-04-02 | 2003-10-16 | H.H. Brown Shoe Technologies, Inc. Doing Business As Dico Technologies | Polyurethane foam products with controlled release of agents and additives |
| US20040030312A1 (en) * | 2002-07-30 | 2004-02-12 | Kainth Arvinder Pal Singh | Superabsorbent materials having low, controlled gel-bed friction angles and composites made from the same |
| US20040044320A1 (en) * | 2002-08-27 | 2004-03-04 | Kainth Arvinder Pal Singh | Composites having controlled friction angles and cohesion values |
| US20040142020A1 (en) * | 2003-01-16 | 2004-07-22 | Healthpoint, Ltd. | Anhydrous, hydrophilic absorbent wound dressing |
| US6768040B1 (en) | 2000-03-27 | 2004-07-27 | Ferris Pharmaceuticals Inc. | Wound dressing for treating injury to nasal passages |
| US20050003178A1 (en) * | 2003-04-21 | 2005-01-06 | Detert James W. | Apparatus and methods for the attachment of materials to polyurethane foam, and articles made using them |
| US20050013987A1 (en) * | 2003-07-16 | 2005-01-20 | Roy Carr | Foam-layered dressing, a method for making the same, a method for applying a dressing, a foam composition, and a foam layer composition produced by a process |
| US6894204B2 (en) | 2001-05-02 | 2005-05-17 | 3M Innovative Properties Company | Tapered stretch removable adhesive articles and methods |
| US20050107731A1 (en) * | 2003-09-22 | 2005-05-19 | Ferris Pharmaceuticals Inc. | Wound dressing suitable for insertion in nasal passages |
| US20050147679A1 (en) * | 1998-03-24 | 2005-07-07 | Petito George D. | Composition and method for healing tissues |
| US20050208114A1 (en) * | 1998-03-24 | 2005-09-22 | Petito George D | Composition and method for healing tissues |
| US6977323B1 (en) | 2000-02-17 | 2005-12-20 | 3M Innovative Properties Company | Foam-on-film medical articles |
| US20060142529A1 (en) * | 2004-02-06 | 2006-06-29 | Verena Thiede | Hydrophilic polyurethane polymers derived from a mdi-based isocyanate-terminated prepolymer |
| US7078582B2 (en) | 2001-01-17 | 2006-07-18 | 3M Innovative Properties Company | Stretch removable adhesive articles and methods |
| US7112320B1 (en) | 1995-06-07 | 2006-09-26 | Andre Beaulieu | Solid wound healing formulations containing fibronectin |
| US20070179210A1 (en) * | 2006-01-31 | 2007-08-02 | Tyco Healthcare Group Lp | Super soft foams |
| US20080021358A1 (en) * | 2005-05-23 | 2008-01-24 | Tucker Kenneth H | Blister inhibiting cover dressing and method of using same |
| US20080146983A1 (en) * | 2006-12-19 | 2008-06-19 | Biopol Co., Ltd. | Polyurethane foam dressing with improved moisturization |
| US20080197065A1 (en) * | 2006-08-18 | 2008-08-21 | Wingo James P | Sintered polymeric materials and applications thereof |
| US7485111B1 (en) * | 2006-06-05 | 2009-02-03 | Eugene Choi | Medicated sleeve |
| US20090069736A1 (en) * | 2002-10-29 | 2009-03-12 | Biopol Co., Ltd. | Polyurethane Foam Dressing for Wound Filler and Method for Manufacturing Thereof |
| US20090112141A1 (en) * | 2007-10-31 | 2009-04-30 | Derr Michael J | Method and apparatus for providing a medical dressing |
| US20090234039A1 (en) * | 2006-05-22 | 2009-09-17 | Basf Se | Shoe soles displaying water absorbing properties |
| US20090250183A1 (en) * | 2008-04-03 | 2009-10-08 | Basf Se | Paper coating or binding formulations and methods of making and using same |
| EP2143744A1 (en) | 2008-07-09 | 2010-01-13 | Bayer MaterialScience AG | Hydrophilic aliphatic polyurethane foams |
| US20100106122A1 (en) * | 2008-10-27 | 2010-04-29 | Sessions Pharmaceuticals Inc. | Fluid extracting wound dressing |
| US20100135915A1 (en) * | 2007-04-21 | 2010-06-03 | Bryan Greener | Foam material for medical use and method for producing same |
| EP2289959A1 (en) | 2009-08-29 | 2011-03-02 | Bayer Material Science AG | Hydrophilic aliphatic polyurethane foams |
| WO2011069972A2 (en) | 2009-12-12 | 2011-06-16 | Bayer Materialscience Ag | Hydrophilic, aliphatic polyurethane foams |
| WO2011083144A1 (en) | 2010-01-11 | 2011-07-14 | Bayer Materialscience Ag | Hydrophilic, aliphatic polyurethane foams |
| WO2012001707A1 (en) | 2010-07-02 | 2012-01-05 | Indian Council Of Agricultural Research | Novel superabsorbents and the method(s) of obtaining the same |
| WO2012055834A1 (en) | 2010-10-27 | 2012-05-03 | Bayer Materialscience Ag | Hydrophilic, aliphatic polyurethane foams |
| WO2012067620A1 (en) * | 2010-11-18 | 2012-05-24 | The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of William Beaumont Army | Spray foam splint |
| WO2012109535A3 (en) * | 2011-02-11 | 2013-02-14 | Bezwada Biomedical, Llc | Amino acid derivatives and absorbable polymers therefrom |
| US20130060216A1 (en) * | 2009-12-24 | 2013-03-07 | Martin Junginger | Hydrogel matrix having improved adhesive properties |
| US8535296B2 (en) | 2002-10-28 | 2013-09-17 | Smith & Nephew Plc | Apparatus for aspirating, irrigating and cleansing wounds |
| US8604099B2 (en) * | 2000-10-20 | 2013-12-10 | Promethean Surgical Devices | In situ bulking composition |
| US8690981B2 (en) | 2011-06-15 | 2014-04-08 | Porex Corporation | Sintered porous plastic liquid barrier media and applications thereof |
| US8901341B2 (en) | 2011-02-11 | 2014-12-02 | Bezwada Biomedical, Llc | Amino acid derivatives and absorbable polymers therefrom |
| US8998866B2 (en) | 2010-07-02 | 2015-04-07 | Smith & Nephew Plc | Provision of wound filler |
| US9040093B2 (en) | 2013-03-13 | 2015-05-26 | Orthovita, Inc. | Bone graft materials containing calcium phosphate and chitosan |
| US9044569B2 (en) | 2004-04-28 | 2015-06-02 | Smith & Nephew Plc | Wound dressing apparatus and method of use |
| US9198801B2 (en) | 2004-04-05 | 2015-12-01 | Bluesky Medical Group, Inc. | Flexible reduced pressure treatment appliance |
| US9358256B2 (en) | 2013-07-11 | 2016-06-07 | Links Medical Products, Inc. | Gap-patterned foam dressing and method of making same |
| WO2017019868A1 (en) | 2015-07-28 | 2017-02-02 | Curaline Inc. | Systems and methods for making hydrophilic foams |
| US9956121B2 (en) | 2007-11-21 | 2018-05-01 | Smith & Nephew Plc | Wound dressing |
| US10058642B2 (en) | 2004-04-05 | 2018-08-28 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
| US10071190B2 (en) | 2008-02-27 | 2018-09-11 | Smith & Nephew Plc | Fluid collection |
| USD830530S1 (en) | 2017-03-17 | 2018-10-09 | Novia Products, Llc | Scent dispenser |
| US10130521B2 (en) | 2008-07-03 | 2018-11-20 | Paul Hartmann Ag | Wound dressing |
| US10143784B2 (en) | 2007-11-21 | 2018-12-04 | T.J. Smith & Nephew Limited | Suction device and dressing |
| US10159604B2 (en) | 2010-04-27 | 2018-12-25 | Smith & Nephew Plc | Wound dressing and method of use |
| US10207035B2 (en) | 2004-05-21 | 2019-02-19 | Smith & Nephew, Inc. | Flexible reduced pressure treatment appliance |
| US10265445B2 (en) | 2002-09-03 | 2019-04-23 | Smith & Nephew, Inc. | Reduced pressure treatment system |
| CN110099941A (en) * | 2016-12-29 | 2019-08-06 | 爱乐康株式会社 | Foaming body and foaming compositions |
| US10537500B2 (en) | 2011-03-24 | 2020-01-21 | Amorepacific Corporation | Cosmetic including urethane foam impregnated with cosmetic composition |
| US10537657B2 (en) | 2010-11-25 | 2020-01-21 | Smith & Nephew Plc | Composition I-II and products and uses thereof |
| US10675392B2 (en) | 2007-12-06 | 2020-06-09 | Smith & Nephew Plc | Wound management |
| USRE48117E1 (en) | 2010-05-07 | 2020-07-28 | Smith & Nephew, Inc. | Apparatuses and methods for negative pressure wound therapy |
| US10912855B2 (en) | 2017-11-02 | 2021-02-09 | Novia Products, Llc | Scent dispenser/absorber and method using same |
| USD910159S1 (en) | 2019-01-30 | 2021-02-09 | Novia Products, Llc | Scent dispenser |
| US11058588B2 (en) | 2009-12-22 | 2021-07-13 | Smith & Nephew, Inc. | Apparatuses and methods for negative pressure wound therapy |
| CN113456877A (en) * | 2021-07-09 | 2021-10-01 | 广西德之然生物科技有限公司 | Organosilicon foam medical dressing and preparation method and application thereof |
| US11207439B2 (en) | 2018-05-01 | 2021-12-28 | Novia Products, Llc | Scent dispenser/absorber |
| USRE48906E1 (en) | 2012-04-12 | 2022-02-01 | Amorepacific Corporation | Foam having improved feeling during use |
| US11247034B2 (en) | 2010-12-22 | 2022-02-15 | Smith & Nephew, Inc. | Apparatuses and methods for negative pressure wound therapy |
| US11255051B2 (en) | 2017-11-29 | 2022-02-22 | Kimberly-Clark Worldwide, Inc. | Fibrous sheet with improved properties |
| US11253399B2 (en) | 2007-12-06 | 2022-02-22 | Smith & Nephew Plc | Wound filling apparatuses and methods |
| US11313061B2 (en) | 2018-07-25 | 2022-04-26 | Kimberly-Clark Worldwide, Inc. | Process for making three-dimensional foam-laid nonwovens |
| US20220241112A1 (en) * | 2010-07-14 | 2022-08-04 | Bard Access Systems, Inc. | Dressing Device for use with a Cannula or a Catheter |
| CN114949334A (en) * | 2013-05-30 | 2022-08-30 | 医疗行业产品有限公司 | Degradable haemostat composition |
| US11591755B2 (en) | 2015-11-03 | 2023-02-28 | Kimberly-Clark Worldwide, Inc. | Paper tissue with high bulk and low lint |
| US11638666B2 (en) | 2011-11-25 | 2023-05-02 | Smith & Nephew Plc | Composition, apparatus, kit and method and uses thereof |
| US11753514B2 (en) * | 2018-08-24 | 2023-09-12 | Cosmetic Foam Llc | Modified formula for hydrophilic foam |
| US11819386B2 (en) | 2018-07-12 | 2023-11-21 | T.J.Smith And Nephew, Limited | Apparatuses and methods for negative pressure wound therapy |
| US11931226B2 (en) | 2013-03-15 | 2024-03-19 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
| US11938231B2 (en) | 2010-11-25 | 2024-03-26 | Smith & Nephew Plc | Compositions I-I and products and uses thereof |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU636668B2 (en) * | 1989-10-18 | 1993-05-06 | Ferris Corp. | Process for preparing a sheet of polymer-based foam |
| US5059424A (en) * | 1989-11-01 | 1991-10-22 | Ndm Acquisition Corp. | Hydrogel wound dressing product |
| GB9102660D0 (en) * | 1991-02-07 | 1991-03-27 | Ultra Lab Ltd | Wound dressing materials |
| DE4111098A1 (en) * | 1991-04-05 | 1992-10-08 | Beiersdorf Ag | HYDROPHILIC SHEARS AND METHOD FOR THE PRODUCTION THEREOF |
| GB9123707D0 (en) * | 1991-11-07 | 1992-01-02 | Johnson & Johnson Medical Ltd | Polyurethane foam |
| DE4242015A1 (en) * | 1992-04-02 | 1993-10-07 | Sebapharma Gmbh & Co | Wound dressing, wound dressing or carrier matrix |
| AU720116B2 (en) * | 1994-11-22 | 2000-05-25 | Huntsman Ici Chemicals Llc | Process for making flexible foams |
| CN1097066C (en) * | 1994-11-22 | 2002-12-25 | 亨茨曼Ici化学品有限公司 | Process for making flexible foams |
| DE19804665B4 (en) * | 1998-02-06 | 2004-09-23 | Beiersdorf Ag | Opaque eye patch |
| GB2336367B (en) * | 1998-04-15 | 2002-03-27 | Johnson & Johnson Medical Ltd | Polyurethane foams for use in wound dressings |
| US6861067B2 (en) | 1998-09-17 | 2005-03-01 | Sherwood Services Ag | Hydrogel wound dressing and the method of making and using the same |
| CN1081527C (en) * | 1998-10-15 | 2002-03-27 | 张坤潢 | Method for producing high-density polyurethane foamed material |
| GB9903097D0 (en) | 1999-02-11 | 1999-03-31 | Johnson & Johnson Medical Ltd | Poyurethane foams for use in wound dressings |
| GB0222522D0 (en) | 2002-09-27 | 2002-11-06 | Controlled Therapeutics Sct | Water-swellable polymers |
| CN101816801B (en) * | 2003-01-09 | 2012-11-14 | 聚合物器官股份有限公司 | Biomedical foams, preparation thereof and application |
| GB2410748A (en) * | 2004-02-03 | 2005-08-10 | Johnson & Johnson Medical Ltd | Medicated polyurethane foams |
| GB0613333D0 (en) | 2006-07-05 | 2006-08-16 | Controlled Therapeutics Sct | Hydrophilic polyurethane compositions |
| KR100937816B1 (en) * | 2007-06-21 | 2010-01-20 | 주식회사 원바이오젠 | A Method for Manufacturing Hydrophilic Wound Dressing and the Hydrophilic Wound Dressing |
| JP5264545B2 (en) * | 2008-06-16 | 2013-08-14 | テルモ株式会社 | Liquid mixing method |
| EP2140888A1 (en) * | 2008-07-04 | 2010-01-06 | Bayer MaterialScience AG | Layered compound, intended as wound dressing, containing a polyurethane foam layer, an absorbent layer and a covering layer |
| SE0901356A1 (en) | 2009-10-20 | 2011-04-21 | Moelnlycke Health Care Ab | Article for use in wound care |
| EP2702969B1 (en) | 2010-08-19 | 2014-10-08 | Paul Hartmann AG | Wound dressing containing foam and ointment base for vacuum therapy, and device for vacuum therapy |
| US9364577B2 (en) | 2011-05-04 | 2016-06-14 | Covestro Deutschland Ag | Hydrophilic polyurethane foam with low volume swelling |
| EP2532326B1 (en) | 2011-06-09 | 2016-03-30 | Paul Hartmann AG | Wound dressing comprising non-woven and salve basis for negative pressure therapy |
| EP2532325B1 (en) | 2011-06-09 | 2014-03-05 | Paul Hartmann AG | Wound dressing comprising foam and cream base and swelling material for negative pressure therapy |
| FR2978443B1 (en) * | 2011-07-26 | 2014-05-09 | Thales Sa | MATERIAL FOR DIELECTRIC SUBSTRATE FOR PRINTED CIRCUIT AND ANTENNAS, METHOD FOR MANUFACTURING SUCH SUBSTRATE CARRYING MEANS FOR INTERCONNECTION BETWEEN TRACKS AND DIELECTRIC SUBSTRATE THUS OBTAINED |
| MX2014007137A (en) | 2011-12-15 | 2014-09-04 | Colgate Palmolive Co | Cleansing compositions with polyurethane-34. |
| NL2008038C2 (en) | 2011-12-23 | 2013-06-26 | Polyganics Bv | Activated or biologically functionalised polymer network. |
| US10092062B2 (en) | 2014-08-27 | 2018-10-09 | Nike, Inc. | Article of footwear with soil-shedding performance |
| TWI706737B (en) | 2014-08-27 | 2020-10-11 | 荷蘭商耐基創新公司 | Article of footwear with soil-shedding performance |
| CN107148226B (en) | 2014-08-27 | 2020-05-22 | 耐克创新有限合伙公司 | Article of footwear, article of clothing and article of sports equipment with water-absorbing properties |
| WO2016181857A1 (en) | 2015-05-08 | 2016-11-17 | バンドー化学株式会社 | Optical transparent adhesive sheet, method for producing optical transparent adhesive sheet, laminate and display device with touch panel |
| JP6163272B1 (en) | 2015-09-29 | 2017-07-12 | バンドー化学株式会社 | Optically transparent adhesive sheet, laminate, laminate production method, and display device with touch panel |
| US11447662B2 (en) | 2015-11-26 | 2022-09-20 | Bando Chemical Industries, Ltd. | Optical transparent adhesive sheet, method for producing optical transparent adhesive sheet, laminated body, and display device with touch panel |
| EP3412740B1 (en) * | 2016-02-02 | 2023-07-12 | Bando Chemical Industries, Ltd. | Optical transparent adhesive sheet, optical transparent adhesive sheet production method, laminate, and touch panel-equipped display device |
| US10531705B2 (en) | 2016-03-02 | 2020-01-14 | Nike, Inc. | Hydrogel tie layer |
| US10975190B2 (en) * | 2016-07-21 | 2021-04-13 | Bionanofoam Llc | Bio-based and hydrophilic polyurethane prepolymer and foam made therefrom |
| CN108355162B (en) * | 2018-05-14 | 2021-07-23 | 江西省科学院应用化学研究所 | Medical dressing of antibiotic hydrophilic polyurethane foam |
| TWI733503B (en) * | 2020-06-22 | 2021-07-11 | 中鎮醫療產品科技股份有限公司 | Polyurethane foam dressing and wound dressing products |
| CN113912817A (en) * | 2021-11-18 | 2022-01-11 | 中电保力（北京）科技有限公司 | Water-swelling and water-blocking filling material and preparation method thereof |
Citations (47)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2017596A (en) * | 1934-05-11 | 1935-10-15 | Otto J Kuhlke | Flexible vehicle |
| US2900278A (en) * | 1956-06-15 | 1959-08-18 | Scott Paper Co | Cellular product and method of making the same |
| US2957834A (en) * | 1953-03-23 | 1960-10-25 | Scholten Chemische Fab | Method of stabilizing soil with an aqueous solution of a cold water swelling starch and a resin |
| US2982394A (en) * | 1955-07-13 | 1961-05-02 | Ohio Commw Eng Co | Soil conditioning package |
| US3419506A (en) * | 1963-02-28 | 1968-12-31 | Johnson & Johnson | Pressurized composition for applying foamed dressings |
| US3419006A (en) * | 1966-08-08 | 1968-12-31 | Union Carbide Corp | Novel dressing and use thereof |
| US3586648A (en) * | 1967-11-13 | 1971-06-22 | Elekal | Flexible and hydrophilic polyurethane foam and a method of making same |
| US3798836A (en) * | 1972-12-04 | 1974-03-26 | Dow Chemical Co | A hydroponic bed for growing plants |
| US3805532A (en) * | 1970-12-21 | 1974-04-23 | Minnesota Mining & Mfg | Consolidation of aggregate material |
| US3889417A (en) * | 1972-08-10 | 1975-06-17 | Grace W R & Co | Method for preparing horticultural foam structures |
| US3961629A (en) * | 1968-06-11 | 1976-06-08 | American Cyanamid Company | Using hydrophilic polyurethane laparotomy sponges |
| US3973355A (en) * | 1974-01-18 | 1976-08-10 | Agritec Co. | Self-contained hydrophilic plant growth matrix and method |
| US4055184A (en) * | 1976-05-10 | 1977-10-25 | Colgate-Palmolive Company | Absorbent pad |
| US4069177A (en) * | 1976-06-21 | 1978-01-17 | Theodore Smith | Water absorbing and urine stable step-wise grafted starch-polyacrylonitrile copolymers |
| US4132839A (en) * | 1976-10-12 | 1979-01-02 | W. R. Grace & Co. | Biodegradable hydrophilic foams and method |
| US4137200A (en) * | 1973-10-09 | 1979-01-30 | W. R. Grace & Co. | Crosslinked hydrophilic foams and method |
| US4156067A (en) * | 1977-06-23 | 1979-05-22 | Tyndale Plains - Hunter Ltd. | Polyurethane polymers characterized by lactone groups and hydroxyl groups in the polymer backbone |
| US4181637A (en) * | 1976-12-24 | 1980-01-01 | Hoechst Aktiengesellschaft | Sheet-like structure of polyurethane, which is capable of absorbing water vapor and transmitting water vapor |
| US4188447A (en) * | 1976-07-20 | 1980-02-12 | Collo Gmbh | Polymeric foam cleaning product |
| US4190563A (en) * | 1977-10-18 | 1980-02-26 | Lever Brothers Company, Inc. | Particulate absorbant material surface treated with polyether to improve dispersibility in blood |
| US4194998A (en) * | 1976-12-06 | 1980-03-25 | The United States Of America As Represented By The Secretary Of Agriculture | Highly absorbent polyhydroxy polymer graft copolymers without saponification |
| US4241537A (en) * | 1979-05-10 | 1980-12-30 | W. R. Grace & Co. | Plant growth media utilizing polyurethane hydrogel |
| US4306551A (en) * | 1980-07-28 | 1981-12-22 | Lectec Corporation | Sterile improved bandage and sealant |
| US4307717A (en) * | 1977-11-07 | 1981-12-29 | Lectec Corporation | Sterile improved bandage containing a medicament |
| US4339550A (en) * | 1981-01-26 | 1982-07-13 | Carter-Wallace, Inc. | Foam products |
| US4341215A (en) * | 1980-09-04 | 1982-07-27 | Tampax Incorporated | Absorbent device |
| US4363319A (en) * | 1980-06-30 | 1982-12-14 | Applied Medical Devices, Inc. | Ready-to-use bandage incorporating a coagulant composition and method of preparing same |
| US4374208A (en) * | 1980-02-20 | 1983-02-15 | Dunlop Limited | Polyether-urethane foams |
| US4394930A (en) * | 1981-03-27 | 1983-07-26 | Johnson & Johnson | Absorbent foam products |
| US4410571A (en) * | 1980-08-25 | 1983-10-18 | Johnson & Johnson | Absorbent products, process and compositions for immobilization of particulate absorbents |
| US4412036A (en) * | 1981-08-05 | 1983-10-25 | Grain Processing Corporation | Composition for absorbent film and method and preparation |
| US4411262A (en) * | 1978-04-21 | 1983-10-25 | Bayer Aktiengesellschaft | Constructional material |
| US4415388A (en) * | 1981-06-22 | 1983-11-15 | Johnson & Johnson | Method of making absorbent bearing products |
| US4497914A (en) * | 1982-07-16 | 1985-02-05 | C. R. Bard, Inc. | Breathable ostomy gasket composition |
| US4517326A (en) * | 1981-06-15 | 1985-05-14 | Freeman Chemical Corporation | Aqueous liquid filled polyurethane gels and method of making the same |
| US4554317A (en) * | 1982-04-06 | 1985-11-19 | David Behar | Synthetic wound covering |
| US4579578A (en) * | 1983-06-04 | 1986-04-01 | Chemical Discoveries S.A. | Plant growing media |
| EP0184233A2 (en) * | 1984-11-13 | 1986-06-11 | Thermedics, Inc. | Drug dispensing wound dressing |
| US4617326A (en) * | 1984-03-14 | 1986-10-14 | Landstingens Inkopscentral Lic Ekonomisk Forening | Bacteria adsorbing composition |
| US4625720A (en) * | 1981-07-02 | 1986-12-02 | Lock Peter M | Wound dressing material |
| US4631227A (en) * | 1982-12-08 | 1986-12-23 | Kenji Nakamura | Toilet article |
| US4664662A (en) * | 1984-08-02 | 1987-05-12 | Smith And Nephew Associated Companies Plc | Wound dressing |
| US4668564A (en) * | 1985-12-26 | 1987-05-26 | Spenco Medical Corporation | Hydrogel materials for hot and cold therapy and method for forming same |
| US4671267A (en) * | 1984-05-30 | 1987-06-09 | Edward I. Stout | Gel-based therapy member and method |
| US4675009A (en) * | 1977-11-07 | 1987-06-23 | Lec Tec Corporation | Drug dispensing device for transdermal delivery of medicaments |
| USRE32476E (en) * | 1970-12-21 | 1987-08-18 | Minnesota Mining And Manufacturing Company | Consolidation of aggregate material |
| US4693713A (en) * | 1981-07-16 | 1987-09-15 | Miroslav Chmelir | Absorbents for blood and serous body fluids |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GR75732B (en) * | 1980-08-25 | 1984-08-02 | Johnson & Johnson | |
| US4731391A (en) * | 1986-07-18 | 1988-03-15 | Kimberly-Clark Corporation | Process of making a superabsorbent polyurethane foam |
-
1988
- 1988-03-29 US US07/175,036 patent/US5064653A/en not_active Expired - Lifetime
-
1989
- 1989-03-28 AT AT89303064T patent/ATE91074T1/en not_active IP Right Cessation
- 1989-03-28 EP EP89303064A patent/EP0335669B1/en not_active Expired - Lifetime
- 1989-03-28 ES ES89303064T patent/ES2057111T3/en not_active Expired - Lifetime
- 1989-03-28 DE DE89303064T patent/DE68907362T2/en not_active Expired - Lifetime
- 1989-03-28 CA CA000594916A patent/CA1322072C/en not_active Expired - Lifetime
- 1989-03-29 CN CN89103214A patent/CN1037523A/en active Pending
- 1989-03-29 KR KR1019890004007A patent/KR0131075B1/en not_active IP Right Cessation
- 1989-03-29 JP JP1077972A patent/JPH07113067B2/en not_active Expired - Fee Related
Patent Citations (50)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2017596A (en) * | 1934-05-11 | 1935-10-15 | Otto J Kuhlke | Flexible vehicle |
| US2957834A (en) * | 1953-03-23 | 1960-10-25 | Scholten Chemische Fab | Method of stabilizing soil with an aqueous solution of a cold water swelling starch and a resin |
| US2982394A (en) * | 1955-07-13 | 1961-05-02 | Ohio Commw Eng Co | Soil conditioning package |
| US2900278A (en) * | 1956-06-15 | 1959-08-18 | Scott Paper Co | Cellular product and method of making the same |
| US3419506A (en) * | 1963-02-28 | 1968-12-31 | Johnson & Johnson | Pressurized composition for applying foamed dressings |
| US3419006A (en) * | 1966-08-08 | 1968-12-31 | Union Carbide Corp | Novel dressing and use thereof |
| US3586648A (en) * | 1967-11-13 | 1971-06-22 | Elekal | Flexible and hydrophilic polyurethane foam and a method of making same |
| US3961629A (en) * | 1968-06-11 | 1976-06-08 | American Cyanamid Company | Using hydrophilic polyurethane laparotomy sponges |
| US3805532A (en) * | 1970-12-21 | 1974-04-23 | Minnesota Mining & Mfg | Consolidation of aggregate material |
| US3805532B1 (en) * | 1970-12-21 | 1985-07-16 | ||
| USRE32476E (en) * | 1970-12-21 | 1987-08-18 | Minnesota Mining And Manufacturing Company | Consolidation of aggregate material |
| US3889417A (en) * | 1972-08-10 | 1975-06-17 | Grace W R & Co | Method for preparing horticultural foam structures |
| US3798836A (en) * | 1972-12-04 | 1974-03-26 | Dow Chemical Co | A hydroponic bed for growing plants |
| US4137200A (en) * | 1973-10-09 | 1979-01-30 | W. R. Grace & Co. | Crosslinked hydrophilic foams and method |
| US3973355A (en) * | 1974-01-18 | 1976-08-10 | Agritec Co. | Self-contained hydrophilic plant growth matrix and method |
| US4055184A (en) * | 1976-05-10 | 1977-10-25 | Colgate-Palmolive Company | Absorbent pad |
| US4069177A (en) * | 1976-06-21 | 1978-01-17 | Theodore Smith | Water absorbing and urine stable step-wise grafted starch-polyacrylonitrile copolymers |
| US4188447A (en) * | 1976-07-20 | 1980-02-12 | Collo Gmbh | Polymeric foam cleaning product |
| US4132839A (en) * | 1976-10-12 | 1979-01-02 | W. R. Grace & Co. | Biodegradable hydrophilic foams and method |
| US4194998A (en) * | 1976-12-06 | 1980-03-25 | The United States Of America As Represented By The Secretary Of Agriculture | Highly absorbent polyhydroxy polymer graft copolymers without saponification |
| US4181637A (en) * | 1976-12-24 | 1980-01-01 | Hoechst Aktiengesellschaft | Sheet-like structure of polyurethane, which is capable of absorbing water vapor and transmitting water vapor |
| US4156067A (en) * | 1977-06-23 | 1979-05-22 | Tyndale Plains - Hunter Ltd. | Polyurethane polymers characterized by lactone groups and hydroxyl groups in the polymer backbone |
| US4190563A (en) * | 1977-10-18 | 1980-02-26 | Lever Brothers Company, Inc. | Particulate absorbant material surface treated with polyether to improve dispersibility in blood |
| US4675009A (en) * | 1977-11-07 | 1987-06-23 | Lec Tec Corporation | Drug dispensing device for transdermal delivery of medicaments |
| US4307717A (en) * | 1977-11-07 | 1981-12-29 | Lectec Corporation | Sterile improved bandage containing a medicament |
| US4411262B1 (en) * | 1978-04-21 | 1985-07-16 | ||
| US4411262A (en) * | 1978-04-21 | 1983-10-25 | Bayer Aktiengesellschaft | Constructional material |
| US4241537A (en) * | 1979-05-10 | 1980-12-30 | W. R. Grace & Co. | Plant growth media utilizing polyurethane hydrogel |
| US4374208A (en) * | 1980-02-20 | 1983-02-15 | Dunlop Limited | Polyether-urethane foams |
| US4363319A (en) * | 1980-06-30 | 1982-12-14 | Applied Medical Devices, Inc. | Ready-to-use bandage incorporating a coagulant composition and method of preparing same |
| US4306551A (en) * | 1980-07-28 | 1981-12-22 | Lectec Corporation | Sterile improved bandage and sealant |
| US4410571A (en) * | 1980-08-25 | 1983-10-18 | Johnson & Johnson | Absorbent products, process and compositions for immobilization of particulate absorbents |
| US4341215A (en) * | 1980-09-04 | 1982-07-27 | Tampax Incorporated | Absorbent device |
| US4339550A (en) * | 1981-01-26 | 1982-07-13 | Carter-Wallace, Inc. | Foam products |
| US4394930A (en) * | 1981-03-27 | 1983-07-26 | Johnson & Johnson | Absorbent foam products |
| US4517326A (en) * | 1981-06-15 | 1985-05-14 | Freeman Chemical Corporation | Aqueous liquid filled polyurethane gels and method of making the same |
| US4415388A (en) * | 1981-06-22 | 1983-11-15 | Johnson & Johnson | Method of making absorbent bearing products |
| US4625720A (en) * | 1981-07-02 | 1986-12-02 | Lock Peter M | Wound dressing material |
| US4693713A (en) * | 1981-07-16 | 1987-09-15 | Miroslav Chmelir | Absorbents for blood and serous body fluids |
| US4412036A (en) * | 1981-08-05 | 1983-10-25 | Grain Processing Corporation | Composition for absorbent film and method and preparation |
| US4554317A (en) * | 1982-04-06 | 1985-11-19 | David Behar | Synthetic wound covering |
| US4497914A (en) * | 1982-07-16 | 1985-02-05 | C. R. Bard, Inc. | Breathable ostomy gasket composition |
| US4631227A (en) * | 1982-12-08 | 1986-12-23 | Kenji Nakamura | Toilet article |
| US4579578A (en) * | 1983-06-04 | 1986-04-01 | Chemical Discoveries S.A. | Plant growing media |
| US4617326A (en) * | 1984-03-14 | 1986-10-14 | Landstingens Inkopscentral Lic Ekonomisk Forening | Bacteria adsorbing composition |
| US4671267A (en) * | 1984-05-30 | 1987-06-09 | Edward I. Stout | Gel-based therapy member and method |
| US4664662A (en) * | 1984-08-02 | 1987-05-12 | Smith And Nephew Associated Companies Plc | Wound dressing |
| US4614787A (en) * | 1984-11-13 | 1986-09-30 | Thermedics, Inc. | Drug dispensing wound dressing |
| EP0184233A2 (en) * | 1984-11-13 | 1986-06-11 | Thermedics, Inc. | Drug dispensing wound dressing |
| US4668564A (en) * | 1985-12-26 | 1987-05-26 | Spenco Medical Corporation | Hydrogel materials for hot and cold therapy and method for forming same |
Non-Patent Citations (6)
| Title |
|---|
| Hypol Laboratory Procedures and Foam Formulations, published by W. R. Grace & Co. * |
| Hypol Plus Laboratory Procedures and Foam Formulations, published by W. R. Grace & Co. * |
| Hypol Plus™ Laboratory Procedures and Foam Formulations, published by W. R. Grace & Co. |
| Hypol® Laboratory Procedures and Foam Formulations, published by W. R. Grace & Co. |
| Witkowski and Parish, Cutaneous Ulcer Therapy, Intermational Journal of Dermatolog vol. 25, No. 7, pp. 420 426, Sep., 1986. * |
| Witkowski and Parish, Cutaneous Ulcer Therapy, Intermational Journal of Dermatolog vol. 25, No. 7, pp. 420-426, Sep., 1986. |
Cited By (208)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5916928A (en) * | 1988-03-29 | 1999-06-29 | Ferris Corporation | Polymer-based porous foam |
| US5833665A (en) * | 1990-06-14 | 1998-11-10 | Integra Lifesciences I, Ltd. | Polyurethane-biopolymer composite |
| US5266608A (en) * | 1990-06-29 | 1993-11-30 | Technion Research & Dev't Foundation, Ltd. | Biomedical adhesive compositions |
| US5562914A (en) * | 1990-12-06 | 1996-10-08 | Zeneca Inc. | Impregnated porous granules and a polyurethane matrix held within the pores thereof and holding a liquid material for controlled release of liquid material and process therefor |
| US5688761A (en) * | 1991-04-19 | 1997-11-18 | Lds Technologies, Inc. | Convertible microemulsion formulations |
| US5646109A (en) * | 1991-04-19 | 1997-07-08 | Lds Technologies, Inc. | Convertible microemulsion formulations |
| US5444041A (en) * | 1991-04-19 | 1995-08-22 | Ibah, Inc. | Convertible microemulsion formulations |
| US5633226A (en) * | 1991-04-19 | 1997-05-27 | Lds Technologies, Inc. | Convertible microemulsion formulations |
| US5571529A (en) * | 1991-11-07 | 1996-11-05 | Johnson & Johnson Medical, Inc. | Method of making polyurethane foam |
| US5578310A (en) * | 1992-04-23 | 1996-11-26 | Berlex Laboratories Inc. | Topical bioadhesive ointment compositions and their use in wound healing |
| DE4233289A1 (en) * | 1992-10-02 | 1994-04-07 | Beiersdorf Ag | Self adhesive polyurethane foam gel contg. water absorber - with non-aq. foaming agents, useful as plasters, wound dressings, etc., adheres to skin but not to wet wounds |
| WO1994008604A1 (en) * | 1992-10-16 | 1994-04-28 | Affinity Biotech, Inc. | Convertible microemulsion formulations |
| US6326410B1 (en) | 1992-11-04 | 2001-12-04 | Johnson & Johnson Medical, Inc. | Wound dressing comprising polyurethane foam |
| DE4308347A1 (en) * | 1993-03-17 | 1994-09-29 | Beiersdorf Ag | Hydrophilic polyurethane foam gels, in particular for the treatment of deep wounds and process for their production |
| DE4308445A1 (en) * | 1993-03-17 | 1994-09-22 | Beiersdorf Ag | Wound dressing based on hydrophilic polyurethane gel foams and process for their production |
| DE4328190A1 (en) * | 1993-08-23 | 1995-03-02 | Beiersdorf Ag | Wound care articles with selective absorbency |
| US5506277A (en) * | 1994-06-30 | 1996-04-09 | Kimberly-Clark Corporation | Starch foams for absorbent articles |
| US5685834A (en) * | 1994-07-29 | 1997-11-11 | Barth; Alan H. | Surgical dressing material |
| US5849850A (en) * | 1994-11-22 | 1998-12-15 | Imperial Chemical Industries Plc | Process for making flexible foams |
| WO1996016643A1 (en) * | 1994-11-28 | 1996-06-06 | The Government Of The United States, As Represented By The Secretary Of The Army | Drug releasing surgical implant or dressing material |
| AU698113B2 (en) * | 1994-11-28 | 1998-10-22 | Government Of The United States Of America, As Represented By The Secretary Of The Army, The | Drug releasing surgical implant or dressing material |
| US5660854A (en) * | 1994-11-28 | 1997-08-26 | Haynes; Duncan H | Drug releasing surgical implant or dressing material |
| US6559353B1 (en) * | 1995-01-19 | 2003-05-06 | Christopher H. Sheridan | Treated disposable articles for reducing skin breakdown |
| US5578317A (en) * | 1995-03-31 | 1996-11-26 | Mulder; Gerit D. | Wound filler and method of manufacture |
| US6528483B2 (en) | 1995-06-07 | 2003-03-04 | André Beaulieu | Method of producing concentrated non-buffered solutions of fibronectin |
| US7112320B1 (en) | 1995-06-07 | 2006-09-26 | Andre Beaulieu | Solid wound healing formulations containing fibronectin |
| US5650450A (en) * | 1996-01-25 | 1997-07-22 | Foamex L.P. | Hydrophilic urethane foam |
| US6349828B1 (en) | 1997-02-06 | 2002-02-26 | Ferris Pharmaceuticals Inc. | Tamper evident packaging |
| US8168599B2 (en) | 1998-03-24 | 2012-05-01 | Petito George D | Composition and method for healing tissues |
| US20100173868A1 (en) * | 1998-03-24 | 2010-07-08 | Petito George D | Composition and method for healing tissues |
| US7691829B2 (en) | 1998-03-24 | 2010-04-06 | Petito George D | Composition and method for healing tissues |
| US20050147679A1 (en) * | 1998-03-24 | 2005-07-07 | Petito George D. | Composition and method for healing tissues |
| US20050208114A1 (en) * | 1998-03-24 | 2005-09-22 | Petito George D | Composition and method for healing tissues |
| US7709005B2 (en) | 1998-06-08 | 2010-05-04 | Sessions Pharmaceuticals Inc. | Method of attenuating neurogenic swelling or neurogenic inflammation |
| US7625585B2 (en) | 1998-06-08 | 2009-12-01 | Sessions Pharmaceuticals Inc. | Method of attenuating neurogenic bruise formation |
| US8486454B2 (en) | 1998-06-08 | 2013-07-16 | Sessions Pharmaceuticals Inc. | Method of attenuating neurogenic pain |
| US7078056B2 (en) | 1998-06-08 | 2006-07-18 | Ferris Pharmaceuticals Inc. | Method of attenuating bruise formation |
| US8101206B2 (en) | 1998-06-08 | 2012-01-24 | Sessions Pharmaceuticals Inc. | Method of attenuating swelling or inflammation |
| US7875294B2 (en) | 1998-06-08 | 2011-01-25 | Sessions Pharmaceuticals Inc. | Method of attenuating bruise formation |
| US20100267640A1 (en) * | 1998-06-08 | 2010-10-21 | Sessions Pharmaceuticals, Inc. | Method of Attenuating Neurogenic Swelling or Neurogenic Inflammation |
| US20060210529A1 (en) * | 1998-06-08 | 2006-09-21 | Ferris Pharmaceuticals Inc. | Method of attenuating neurogenic bruise formation |
| US6447802B2 (en) | 1998-06-08 | 2002-09-10 | Ferris Corporation | Analgesic and antinociceptive methods |
| US6451301B1 (en) * | 1998-06-08 | 2002-09-17 | Ferris Corporation | Analgesic and antinociceptive methods |
| US20070025924A1 (en) * | 1998-06-08 | 2007-02-01 | Ferris Pharmaceuticals, Inc. | Method of attenuating swelling or inflammation |
| US7078055B2 (en) * | 1998-06-08 | 2006-07-18 | Ferris Pharmaceuticals Inc. | Method of attenuating swelling or inflammation |
| US20070025925A1 (en) * | 1998-06-08 | 2007-02-01 | Ferris Pharmaceuticals, Inc. | Method of attenuating neurogenic swelling or neurogenic inflammation |
| US20070059251A1 (en) * | 1998-06-08 | 2007-03-15 | Ferris Pharmaceuticals, Inc. | Method of attenuating bruise formation |
| US20070025922A1 (en) * | 1998-06-08 | 2007-02-01 | Ferris Pharmaceuticals, Inc. | Method of attenuating neurogenic pain |
| US6198016B1 (en) | 1998-12-01 | 2001-03-06 | 3M Innovative Properties Company | Wet skin adhesive article |
| US6617014B1 (en) * | 1999-09-01 | 2003-09-09 | Hydrophilix, Llc | Foam composite |
| US6881875B2 (en) | 2000-02-17 | 2005-04-19 | 3M Innovative Properties Company | Foam/film composite medical articles |
| US6977323B1 (en) | 2000-02-17 | 2005-12-20 | 3M Innovative Properties Company | Foam-on-film medical articles |
| EP2138194A1 (en) | 2000-02-17 | 2009-12-30 | 3M Innovative Properties Company | Foam-on-film medical articles |
| US6548727B1 (en) | 2000-02-17 | 2003-04-15 | 3M Innovative Properties Company | Foam/film composite medical articles |
| US6768040B1 (en) | 2000-03-27 | 2004-07-27 | Ferris Pharmaceuticals Inc. | Wound dressing for treating injury to nasal passages |
| US7048966B2 (en) | 2000-03-31 | 2006-05-23 | Hydrophilix, Llc | Foam composite |
| US20060216492A1 (en) * | 2000-03-31 | 2006-09-28 | Hydrophilix, Llc | Foam Composite |
| US20060013963A1 (en) * | 2000-03-31 | 2006-01-19 | Hydrophilix, Llc | Foam composite |
| US8604099B2 (en) * | 2000-10-20 | 2013-12-10 | Promethean Surgical Devices | In situ bulking composition |
| EP1345636B1 (en) * | 2000-12-27 | 2005-03-16 | Healthpoint, LTD. | Anhydrous, hydrophilic absorbent wound dressing |
| US6399092B1 (en) * | 2000-12-27 | 2002-06-04 | Healthpoint, Ltd. | Anhydrous, hydrophilic absorbent wound dressing (tube) with antimicrobials or other pharmaceutically active agents |
| US7078582B2 (en) | 2001-01-17 | 2006-07-18 | 3M Innovative Properties Company | Stretch removable adhesive articles and methods |
| US6894204B2 (en) | 2001-05-02 | 2005-05-17 | 3M Innovative Properties Company | Tapered stretch removable adhesive articles and methods |
| WO2003084579A1 (en) * | 2002-04-02 | 2003-10-16 | H.H. Brown Shoe Technologies, Inc. Doing Business As Dico Technologies | Polyurethane foam products with controlled release of agents and additives |
| US20030207954A1 (en) * | 2002-04-02 | 2003-11-06 | H.H. Brown Shoe Technologies, Inc. D/B/A Dicon Technologies | Urethane polymer foam composites with controlled release of agents and additives having abrasive qualities |
| US20030216483A1 (en) * | 2002-04-02 | 2003-11-20 | H.H. Brown Shoe Technologies, Inc. D/B/A Dicon Technologies | Urethane polymer foam composites in sized particulate form with controlled release of agents and additives |
| US6706775B2 (en) | 2002-04-02 | 2004-03-16 | H. H. Brown Shoe Technologies, Inc. | Polyurethane foam products with controlled release of agents and additives |
| US20040030312A1 (en) * | 2002-07-30 | 2004-02-12 | Kainth Arvinder Pal Singh | Superabsorbent materials having low, controlled gel-bed friction angles and composites made from the same |
| US7297395B2 (en) | 2002-07-30 | 2007-11-20 | Kimberly-Clark Worldwide, Inc. | Superabsorbent materials having low, controlled gel-bed friction angles and composites made from the same |
| US20040044320A1 (en) * | 2002-08-27 | 2004-03-04 | Kainth Arvinder Pal Singh | Composites having controlled friction angles and cohesion values |
| US11376356B2 (en) | 2002-09-03 | 2022-07-05 | Smith & Nephew, Inc. | Reduced pressure treatment system |
| US10265445B2 (en) | 2002-09-03 | 2019-04-23 | Smith & Nephew, Inc. | Reduced pressure treatment system |
| US11298454B2 (en) | 2002-09-03 | 2022-04-12 | Smith & Nephew, Inc. | Reduced pressure treatment system |
| US9205001B2 (en) | 2002-10-28 | 2015-12-08 | Smith & Nephew Plc | Apparatus for aspirating, irrigating and cleansing wounds |
| US8535296B2 (en) | 2002-10-28 | 2013-09-17 | Smith & Nephew Plc | Apparatus for aspirating, irrigating and cleansing wounds |
| US10842678B2 (en) | 2002-10-28 | 2020-11-24 | Smith & Nephew Plc | Apparatus for aspirating, irrigating and cleansing wounds |
| US8834451B2 (en) | 2002-10-28 | 2014-09-16 | Smith & Nephew Plc | In-situ wound cleansing apparatus |
| US9387126B2 (en) | 2002-10-28 | 2016-07-12 | Smith & Nephew Plc | Apparatus for aspirating, irrigating and cleansing wounds |
| US10278869B2 (en) | 2002-10-28 | 2019-05-07 | Smith & Nephew Plc | Apparatus for aspirating, irrigating and cleansing wounds |
| US9844474B2 (en) | 2002-10-28 | 2017-12-19 | Smith & Nephew Plc | Apparatus for aspirating, irrigating and cleansing wounds |
| US9844473B2 (en) | 2002-10-28 | 2017-12-19 | Smith & Nephew Plc | Apparatus for aspirating, irrigating and cleansing wounds |
| US7777090B2 (en) | 2002-10-29 | 2010-08-17 | Biopol Co., Ltd. | Polyurethane foam dressing for wound filler and method for manufacturing thereof |
| US20090069736A1 (en) * | 2002-10-29 | 2009-03-12 | Biopol Co., Ltd. | Polyurethane Foam Dressing for Wound Filler and Method for Manufacturing Thereof |
| US20040142020A1 (en) * | 2003-01-16 | 2004-07-22 | Healthpoint, Ltd. | Anhydrous, hydrophilic absorbent wound dressing |
| WO2004064882A1 (en) * | 2003-01-16 | 2004-08-05 | Healthpoint, Ltd. | Anhydrous, hydrophilic superabsorbent wound dressing |
| US20090008021A1 (en) * | 2003-04-21 | 2009-01-08 | Rynel, Inc. | Apparatus and Methods for the Attachment of Materials to Polyurethane Foam, and Articles Made Using Them |
| US8211255B2 (en) | 2003-04-21 | 2012-07-03 | Rynel Inc. | Apparatus and methods for the attachment of materials to polyurethane foam, and articles made using them |
| US20050003178A1 (en) * | 2003-04-21 | 2005-01-06 | Detert James W. | Apparatus and methods for the attachment of materials to polyurethane foam, and articles made using them |
| US20050013987A1 (en) * | 2003-07-16 | 2005-01-20 | Roy Carr | Foam-layered dressing, a method for making the same, a method for applying a dressing, a foam composition, and a foam layer composition produced by a process |
| US20050107731A1 (en) * | 2003-09-22 | 2005-05-19 | Ferris Pharmaceuticals Inc. | Wound dressing suitable for insertion in nasal passages |
| US7022890B2 (en) | 2003-09-22 | 2006-04-04 | Ferris Pharmaceuticals | Wound dressing suitable for insertion in nasal passages |
| US20060142529A1 (en) * | 2004-02-06 | 2006-06-29 | Verena Thiede | Hydrophilic polyurethane polymers derived from a mdi-based isocyanate-terminated prepolymer |
| US10363346B2 (en) | 2004-04-05 | 2019-07-30 | Smith & Nephew, Inc. | Flexible reduced pressure treatment appliance |
| US10350339B2 (en) | 2004-04-05 | 2019-07-16 | Smith & Nephew, Inc. | Flexible reduced pressure treatment appliance |
| US10058642B2 (en) | 2004-04-05 | 2018-08-28 | Bluesky Medical Group Incorporated | Reduced pressure treatment system |
| US10842919B2 (en) | 2004-04-05 | 2020-11-24 | Smith & Nephew, Inc. | Reduced pressure treatment system |
| US9198801B2 (en) | 2004-04-05 | 2015-12-01 | Bluesky Medical Group, Inc. | Flexible reduced pressure treatment appliance |
| US11730874B2 (en) | 2004-04-05 | 2023-08-22 | Smith & Nephew, Inc. | Reduced pressure treatment appliance |
| US10105471B2 (en) | 2004-04-05 | 2018-10-23 | Smith & Nephew, Inc. | Reduced pressure treatment system |
| US9044569B2 (en) | 2004-04-28 | 2015-06-02 | Smith & Nephew Plc | Wound dressing apparatus and method of use |
| US10758425B2 (en) | 2004-04-28 | 2020-09-01 | Smith & Nephew Plc | Negative pressure wound therapy dressing system |
| US10758424B2 (en) | 2004-04-28 | 2020-09-01 | Smith & Nephew Plc | Dressing and apparatus for cleansing the wounds |
| US10039868B2 (en) | 2004-04-28 | 2018-08-07 | Smith & Nephew Plc | Dressing and apparatus for cleansing the wounds |
| US9950100B2 (en) | 2004-04-28 | 2018-04-24 | Smith & Nephew Plc | Negative pressure wound therapy dressing system |
| US10207035B2 (en) | 2004-05-21 | 2019-02-19 | Smith & Nephew, Inc. | Flexible reduced pressure treatment appliance |
| US20080021358A1 (en) * | 2005-05-23 | 2008-01-24 | Tucker Kenneth H | Blister inhibiting cover dressing and method of using same |
| US20070179210A1 (en) * | 2006-01-31 | 2007-08-02 | Tyco Healthcare Group Lp | Super soft foams |
| US9808554B2 (en) | 2006-01-31 | 2017-11-07 | Covidien Lp | Super soft foams |
| US20090234039A1 (en) * | 2006-05-22 | 2009-09-17 | Basf Se | Shoe soles displaying water absorbing properties |
| US20090118685A1 (en) * | 2006-06-05 | 2009-05-07 | United Exchange Corporation | Medicated sleeve |
| US7485111B1 (en) * | 2006-06-05 | 2009-02-03 | Eugene Choi | Medicated sleeve |
| US7959616B2 (en) | 2006-06-05 | 2011-06-14 | Eugene Choi | Medicated sleeve |
| US20110208137A1 (en) * | 2006-06-05 | 2011-08-25 | United Exchange Corporation | Medicated sleeve |
| US8141717B2 (en) * | 2006-08-18 | 2012-03-27 | Porex Corporation | Sintered polymeric materials and applications thereof |
| US20080197065A1 (en) * | 2006-08-18 | 2008-08-21 | Wingo James P | Sintered polymeric materials and applications thereof |
| US20080146983A1 (en) * | 2006-12-19 | 2008-06-19 | Biopol Co., Ltd. | Polyurethane foam dressing with improved moisturization |
| US7777091B2 (en) | 2006-12-19 | 2010-08-17 | Biopol Co., Ltd. | Polyurethane foam dressing with improved moisturization |
| US20100135915A1 (en) * | 2007-04-21 | 2010-06-03 | Bryan Greener | Foam material for medical use and method for producing same |
| US20090112141A1 (en) * | 2007-10-31 | 2009-04-30 | Derr Michael J | Method and apparatus for providing a medical dressing |
| US10744041B2 (en) | 2007-11-21 | 2020-08-18 | Smith & Nephew Plc | Wound dressing |
| US11351064B2 (en) | 2007-11-21 | 2022-06-07 | Smith & Nephew Plc | Wound dressing |
| US10231875B2 (en) | 2007-11-21 | 2019-03-19 | Smith & Nephew Plc | Wound dressing |
| US10143784B2 (en) | 2007-11-21 | 2018-12-04 | T.J. Smith & Nephew Limited | Suction device and dressing |
| US11364151B2 (en) | 2007-11-21 | 2022-06-21 | Smith & Nephew Plc | Wound dressing |
| US11766512B2 (en) | 2007-11-21 | 2023-09-26 | T.J.Smith And Nephew, Limited | Suction device and dressing |
| US11179276B2 (en) | 2007-11-21 | 2021-11-23 | Smith & Nephew Plc | Wound dressing |
| US10016309B2 (en) | 2007-11-21 | 2018-07-10 | Smith & Nephew Plc | Wound dressing |
| US11129751B2 (en) | 2007-11-21 | 2021-09-28 | Smith & Nephew Plc | Wound dressing |
| US11344663B2 (en) | 2007-11-21 | 2022-05-31 | T.J.Smith And Nephew, Limited | Suction device and dressing |
| US9956121B2 (en) | 2007-11-21 | 2018-05-01 | Smith & Nephew Plc | Wound dressing |
| US10555839B2 (en) | 2007-11-21 | 2020-02-11 | Smith & Nephew Plc | Wound dressing |
| US10675392B2 (en) | 2007-12-06 | 2020-06-09 | Smith & Nephew Plc | Wound management |
| US11253399B2 (en) | 2007-12-06 | 2022-02-22 | Smith & Nephew Plc | Wound filling apparatuses and methods |
| US11141520B2 (en) | 2008-02-27 | 2021-10-12 | Smith & Nephew Plc | Fluid collection |
| US10071190B2 (en) | 2008-02-27 | 2018-09-11 | Smith & Nephew Plc | Fluid collection |
| US9074322B2 (en) | 2008-04-03 | 2015-07-07 | Basf Se | Paper coating or binding formulations and methods of making and using same |
| US8613834B2 (en) | 2008-04-03 | 2013-12-24 | Basf Se | Paper coating or binding formulations and methods of making and using same |
| US20090250183A1 (en) * | 2008-04-03 | 2009-10-08 | Basf Se | Paper coating or binding formulations and methods of making and using same |
| US10130521B2 (en) | 2008-07-03 | 2018-11-20 | Paul Hartmann Ag | Wound dressing |
| US20110184080A1 (en) * | 2008-07-09 | 2011-07-28 | Bayer Materialscience Ag | Hydrophilic, aliphatic polyurethane foams |
| EP2143744A1 (en) | 2008-07-09 | 2010-01-13 | Bayer MaterialScience AG | Hydrophilic aliphatic polyurethane foams |
| US20100106122A1 (en) * | 2008-10-27 | 2010-04-29 | Sessions Pharmaceuticals Inc. | Fluid extracting wound dressing |
| WO2011023762A2 (en) | 2009-08-29 | 2011-03-03 | Bayer Materialscience Ag | Hydrophilic aliphatic polyurethane foams |
| US8980966B2 (en) | 2009-08-29 | 2015-03-17 | Bayer Materialscience Ag | Hydrophilic aliphatic polyurethane foams |
| EP2289959A1 (en) | 2009-08-29 | 2011-03-02 | Bayer Material Science AG | Hydrophilic aliphatic polyurethane foams |
| EP2336211A1 (en) | 2009-12-12 | 2011-06-22 | Bayer MaterialScience AG | Hydrophilic aliphatic polyurethane foams |
| WO2011069972A2 (en) | 2009-12-12 | 2011-06-16 | Bayer Materialscience Ag | Hydrophilic, aliphatic polyurethane foams |
| US11058588B2 (en) | 2009-12-22 | 2021-07-13 | Smith & Nephew, Inc. | Apparatuses and methods for negative pressure wound therapy |
| US20130060216A1 (en) * | 2009-12-24 | 2013-03-07 | Martin Junginger | Hydrogel matrix having improved adhesive properties |
| US9579413B2 (en) * | 2009-12-24 | 2017-02-28 | Paul Hartmann Ag | Hydrogel matrix having improved adhesive properties |
| WO2011083144A1 (en) | 2010-01-11 | 2011-07-14 | Bayer Materialscience Ag | Hydrophilic, aliphatic polyurethane foams |
| US8946315B2 (en) | 2010-01-11 | 2015-02-03 | Bayer Intellectual Property Gmbh | Hydrophilic aliphatic polyurethane foams |
| US11090195B2 (en) | 2010-04-27 | 2021-08-17 | Smith & Nephew Plc | Wound dressing and method of use |
| US11058587B2 (en) | 2010-04-27 | 2021-07-13 | Smith & Nephew Plc | Wound dressing and method of use |
| US10159604B2 (en) | 2010-04-27 | 2018-12-25 | Smith & Nephew Plc | Wound dressing and method of use |
| USRE48117E1 (en) | 2010-05-07 | 2020-07-28 | Smith & Nephew, Inc. | Apparatuses and methods for negative pressure wound therapy |
| US9801761B2 (en) | 2010-07-02 | 2017-10-31 | Smith & Nephew Plc | Provision of wound filler |
| US9833767B2 (en) | 2010-07-02 | 2017-12-05 | Indian Council Of Agricultural Research | Superabsorbents and the method(s) of obtaining the same |
| US8998866B2 (en) | 2010-07-02 | 2015-04-07 | Smith & Nephew Plc | Provision of wound filler |
| WO2012001707A1 (en) | 2010-07-02 | 2012-01-05 | Indian Council Of Agricultural Research | Novel superabsorbents and the method(s) of obtaining the same |
| US20220241112A1 (en) * | 2010-07-14 | 2022-08-04 | Bard Access Systems, Inc. | Dressing Device for use with a Cannula or a Catheter |
| WO2012055834A1 (en) | 2010-10-27 | 2012-05-03 | Bayer Materialscience Ag | Hydrophilic, aliphatic polyurethane foams |
| US9458300B2 (en) | 2010-10-27 | 2016-10-04 | Covestro Deutschland Ag | Hydrophilic, aliphatic polyurethane foams |
| US9427489B2 (en) * | 2010-11-18 | 2016-08-30 | Kevin D. Martin | Spray foam splint |
| US20130324897A1 (en) * | 2010-11-18 | 2013-12-05 | Usa, As Represented By The Secretary Of The Army | Spray foam splint |
| WO2012067620A1 (en) * | 2010-11-18 | 2012-05-24 | The United States Of America, As Represented By The Secretary Of The Army, On Behalf Of William Beaumont Army | Spray foam splint |
| US11730876B2 (en) | 2010-11-25 | 2023-08-22 | Smith & Nephew Plc | Composition I-II and products and uses thereof |
| US10537657B2 (en) | 2010-11-25 | 2020-01-21 | Smith & Nephew Plc | Composition I-II and products and uses thereof |
| US11938231B2 (en) | 2010-11-25 | 2024-03-26 | Smith & Nephew Plc | Compositions I-I and products and uses thereof |
| US11247034B2 (en) | 2010-12-22 | 2022-02-15 | Smith & Nephew, Inc. | Apparatuses and methods for negative pressure wound therapy |
| US10689330B2 (en) | 2011-02-11 | 2020-06-23 | Bezwada Biomedical, Llc | Amino acid derivatives and absorbable polymers therefrom |
| US9868696B2 (en) | 2011-02-11 | 2018-01-16 | Bezwada Biomedial, LLC | Amino acid derivatives and absorbable polymers therefrom |
| US9012677B2 (en) | 2011-02-11 | 2015-04-21 | Bezwada Biomedical, Llc | Amino acid derivatives and absorbable polymers therefrom |
| US10550072B2 (en) | 2011-02-11 | 2020-02-04 | Bezwada Biomedical, Llc | Amino acid derivatives and absorbable polymers therefrom |
| WO2012109535A3 (en) * | 2011-02-11 | 2013-02-14 | Bezwada Biomedical, Llc | Amino acid derivatives and absorbable polymers therefrom |
| US8901341B2 (en) | 2011-02-11 | 2014-12-02 | Bezwada Biomedical, Llc | Amino acid derivatives and absorbable polymers therefrom |
| US8461372B2 (en) | 2011-02-11 | 2013-06-11 | Rao S. Bezwada | Amino acid derivatives and absorbable polymers therefrom |
| US10925812B2 (en) | 2011-03-24 | 2021-02-23 | Amorepacific Corporation | Urethane foam for use in impregnating cosmetic composition |
| US10537500B2 (en) | 2011-03-24 | 2020-01-21 | Amorepacific Corporation | Cosmetic including urethane foam impregnated with cosmetic composition |
| US10537501B2 (en) | 2011-03-24 | 2020-01-21 | Amorepacific Corporation | Urethane foam for use in impregnating cosmetic composition |
| US10603254B2 (en) | 2011-03-24 | 2020-03-31 | Amorepacific Corporation | Urethane foam for use in impregnating cosmetic composition |
| US8690981B2 (en) | 2011-06-15 | 2014-04-08 | Porex Corporation | Sintered porous plastic liquid barrier media and applications thereof |
| US9370731B2 (en) | 2011-06-15 | 2016-06-21 | Porex Corporation | Sintered porous plastic liquid barrier media and applications thereof |
| US11638666B2 (en) | 2011-11-25 | 2023-05-02 | Smith & Nephew Plc | Composition, apparatus, kit and method and uses thereof |
| USRE48906E1 (en) | 2012-04-12 | 2022-02-01 | Amorepacific Corporation | Foam having improved feeling during use |
| USRE49062E1 (en) | 2012-04-12 | 2022-05-10 | Amorepacific Corporation | Foam having improved feeling during use |
| US9040093B2 (en) | 2013-03-13 | 2015-05-26 | Orthovita, Inc. | Bone graft materials containing calcium phosphate and chitosan |
| US11931226B2 (en) | 2013-03-15 | 2024-03-19 | Smith & Nephew Plc | Wound dressing sealant and use thereof |
| CN114949334A (en) * | 2013-05-30 | 2022-08-30 | 医疗行业产品有限公司 | Degradable haemostat composition |
| US9358256B2 (en) | 2013-07-11 | 2016-06-07 | Links Medical Products, Inc. | Gap-patterned foam dressing and method of making same |
| EP3328460A4 (en) * | 2015-07-28 | 2019-03-27 | NewMedical Technology, Inc. | Systems and methods for making hydrophilic foams |
| US11246957B2 (en) | 2015-07-28 | 2022-02-15 | Newmedical Technology, Inc. | Systems and methods for making hydrophilic foams |
| WO2017019868A1 (en) | 2015-07-28 | 2017-02-02 | Curaline Inc. | Systems and methods for making hydrophilic foams |
| US11591755B2 (en) | 2015-11-03 | 2023-02-28 | Kimberly-Clark Worldwide, Inc. | Paper tissue with high bulk and low lint |
| CN110099941A (en) * | 2016-12-29 | 2019-08-06 | 爱乐康株式会社 | Foaming body and foaming compositions |
| EP3564281A4 (en) * | 2016-12-29 | 2020-09-09 | Alcare Co., Ltd. | Foam body and foam body composition |
| US11952455B2 (en) | 2016-12-29 | 2024-04-09 | Alcare Co., Ltd. | Foam and composition for foam |
| USD830530S1 (en) | 2017-03-17 | 2018-10-09 | Novia Products, Llc | Scent dispenser |
| US10912855B2 (en) | 2017-11-02 | 2021-02-09 | Novia Products, Llc | Scent dispenser/absorber and method using same |
| US11255051B2 (en) | 2017-11-29 | 2022-02-22 | Kimberly-Clark Worldwide, Inc. | Fibrous sheet with improved properties |
| US11207439B2 (en) | 2018-05-01 | 2021-12-28 | Novia Products, Llc | Scent dispenser/absorber |
| US11819386B2 (en) | 2018-07-12 | 2023-11-21 | T.J.Smith And Nephew, Limited | Apparatuses and methods for negative pressure wound therapy |
| US11788221B2 (en) | 2018-07-25 | 2023-10-17 | Kimberly-Clark Worldwide, Inc. | Process for making three-dimensional foam-laid nonwovens |
| US11313061B2 (en) | 2018-07-25 | 2022-04-26 | Kimberly-Clark Worldwide, Inc. | Process for making three-dimensional foam-laid nonwovens |
| US11753514B2 (en) * | 2018-08-24 | 2023-09-12 | Cosmetic Foam Llc | Modified formula for hydrophilic foam |
| USD910159S1 (en) | 2019-01-30 | 2021-02-09 | Novia Products, Llc | Scent dispenser |
| CN113456877B (en) * | 2021-07-09 | 2023-04-11 | 广西德之然生物科技有限公司 | Organosilicon foam medical dressing and preparation method and application thereof |
| CN113456877A (en) * | 2021-07-09 | 2021-10-01 | 广西德之然生物科技有限公司 | Organosilicon foam medical dressing and preparation method and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CA1322072C (en) | 1993-09-07 |
| ATE91074T1 (en) | 1993-07-15 |
| JPH07113067B2 (en) | 1995-12-06 |
| KR0131075B1 (en) | 1998-04-17 |
| KR890014642A (en) | 1989-10-25 |
| ES2057111T3 (en) | 1994-10-16 |
| EP0335669A2 (en) | 1989-10-04 |
| CN1037523A (en) | 1989-11-29 |
| EP0335669B1 (en) | 1993-06-30 |
| EP0335669A3 (en) | 1990-01-31 |
| DE68907362T2 (en) | 1993-10-14 |
| DE68907362D1 (en) | 1993-08-05 |
| JPH0243231A (en) | 1990-02-13 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| US5064653A (en) | Hydrophilic foam compositions | |
| US5065752A (en) | Hydrophilic foam compositions | |
| US5254301A (en) | Process for preparing a sheet of polymer-based foam | |
| AU2003208303B2 (en) | A wound care device | |
| US20220331478A1 (en) | Systems and Methods for Making Hydrophilic Foams | |
| JP3345059B2 (en) | Production method of polyurethane foam | |
| CA2082365C (en) | Wound dressing comprising polyurethane foam | |
| JP5020639B2 (en) | Medicinal polyurethane foam | |
| US6326410B1 (en) | Wound dressing comprising polyurethane foam | |
| CA2486057A1 (en) | Hydrophilic foam compositions having antimicrobial properties | |
| JPH04122255A (en) | Multilayer bandage | |
| AU756214B2 (en) | Polyurethane foams for use in wound dressings | |
| CA2027894C (en) | Process for preparing a sheet of polymer-based foam | |
| AU624808B2 (en) | Hydrophilic foam compositions | |
| EP4338762A1 (en) | Process of producing a highly absorbent hydrogel composition for medical purposes, in particular for wound treatment |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| AS | Assignment |
Owner name: FERRIS MFG. CO., 300 W. 83RD STREET, BURR RIDGE, I Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:SESSIONS, ROBERT W.;CARR, ROY D.;REEL/FRAME:004887/0337 Effective date: 19880329 Owner name: FERRIS MFG. CO., A CORPORATION OF DELAWARE,ILLINOI Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNORS:SESSIONS, ROBERT W.;CARR, ROY D.;REEL/FRAME:004887/0337 Effective date: 19880329 |
|
| AS | Assignment |
Owner name: FERRIS MFG. CORP., A CORP. OF DELAWARE, ILLINOIS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST.;ASSIGNORS:SESSIONS, ROBERT W.;CARR, ROY D.;REEL/FRAME:005278/0831 Effective date: 19900410 |
|
| STCF | Information on status: patent grant |
Free format text: PATENTED CASE |
|
| CC | Certificate of correction | ||
| AS | Assignment |
Owner name: FERRIS CORP., ILLINOIS Free format text: ASSIGNMENT OF ASSIGNORS INTEREST;ASSIGNOR:FERRIS MANUFACTURING CORP.;REEL/FRAME:006721/0419 Effective date: 19930927 |
|
| FEPP | Fee payment procedure |
Free format text: PAYOR NUMBER ASSIGNED (ORIGINAL EVENT CODE: ASPN); ENTITY STATUS OF PATENT OWNER: SMALL ENTITY |
|
| FPAY | Fee payment |
Year of fee payment: 4 |
|
| FPAY | Fee payment |
Year of fee payment: 8 |
|
| AS | Assignment |
Owner name: FERRIS PHARMACEUTICALS INC., ILLINOIS Free format text: CHANGE OF NAME;ASSIGNOR:FERRIS CORPORATION;REEL/FRAME:010901/0993 Effective date: 19980718 |
|
| FPAY | Fee payment |
Year of fee payment: 12 |