US5262164A - Sustained release compositions for treating periodontal disease - Google Patents

Sustained release compositions for treating periodontal disease Download PDF

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Publication number
US5262164A
US5262164A US07/439,064 US43906489A US5262164A US 5262164 A US5262164 A US 5262164A US 43906489 A US43906489 A US 43906489A US 5262164 A US5262164 A US 5262164A
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United States
Prior art keywords
oral cavity
composition
drug active
compositions
monoolein
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US07/439,064
Inventor
Nalinkant C. Damani
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Xellia Pharmaceuticals ApS
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Procter and Gamble Co
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Priority to US07/439,064 priority Critical patent/US5262164A/en
Assigned to PROCTER & GAMBLE COMPANY, THE reassignment PROCTER & GAMBLE COMPANY, THE ASSIGNMENT OF ASSIGNORS INTEREST. Assignors: DAMANI, NALINKANT C.
Priority to CA002029050A priority patent/CA2029050C/en
Priority to DE69025270T priority patent/DE69025270T2/en
Priority to EP90312246A priority patent/EP0429224B1/en
Priority to ES90312246T priority patent/ES2082833T3/en
Priority to DK90312246.3T priority patent/DK0429224T3/en
Priority to AT90312246T priority patent/ATE133858T1/en
Priority to EP95106829A priority patent/EP0671175A3/en
Priority to KR1019900018464A priority patent/KR0156916B1/en
Priority to PT95896A priority patent/PT95896B/en
Priority to IE414990A priority patent/IE72515B1/en
Priority to JP2311261A priority patent/JPH03209313A/en
Priority to AU66678/90A priority patent/AU648761B2/en
Priority to FI905682A priority patent/FI98124C/en
Publication of US5262164A publication Critical patent/US5262164A/en
Application granted granted Critical
Priority to GR950403547T priority patent/GR3018933T3/en
Assigned to DUMEX-ALPHARMA A/S reassignment DUMEX-ALPHARMA A/S ASSIGNMENT OF ASSIGNORS INTEREST (SEE DOCUMENT FOR DETAILS). Assignors: PROCTER & GAMBLE COMPANY, THE
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/10Dispersions; Emulsions
    • A61K9/127Liposomes
    • A61K9/1274Non-vesicle bilayer structures, e.g. liquid crystals, tubules, cubic phases, cochleates; Sponge phases
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0063Periodont
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/20Pills, tablets, discs, rods
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis

Definitions

  • This invention relates to compositions for treating diseases of the oral cavity, which compositions are placed in or around the periodontal pocket.
  • the invention also relates to methods of using the compositions in humans and lower animals suffering from such diseases.
  • Periodontal disease for example, is a major cause of tooth loss in adults. Tooth loss from periodontal disease is a significant problem beginning at age 35, but even by age 15 it is estimated that about 4 out of 5 persons already have gingivitis and 4 out of 10 have periodontitis.
  • Gel forming materials like hydroxypropyl methyl cellulose or pluronic F-127 polyol have been utilized in the past without success. It has been found that instead of using such hydrophilic or water soluble materials, desirable physical properties, convenience of placement and duration of retention can also be achieved by using materials that have limited water solubility. What is surprising, however, is that some of these materials are capable of absorbing water and undergoing increase in viscosity, providing a most desirable feature to treat disorders of the oral cavity.
  • compositions employing glycerol monooleate (monoolein) gels provide for easy placement in and around the periodontal pocket and good drug release.
  • a material such as monoolein
  • an active agent When a material such as monoolein is compounded with an active agent and placed into or around the periodontal cavity, it absorbs water from the surrounding body fluid and becomes more viscous. Since monoolein is not miscible with water, it provides extended duration of retention at the site of treatment. The active agent is slowly released from the composition in a controlled manner over extended duration.
  • the present invention relates to compositions and methods for treating diseases of the oral cavity by inserting the compositions into or around the periodontal pocket of humans and/or lower animals.
  • the compositions comprise monooleate and an agent providing relief of diseases of the oral cavity.
  • the gelling agent useful with the present invention is a monooleate ester of glycerol (monoolein).
  • Monoolein is an item of commerce and is available from C. P. Hall and Co. as CPH-362-N. This agent can easily be formulated with the drug active and be easily positioned into and around the periodontal pocket.
  • Monoolein comprises the bulk of the compositions of the present invention.
  • the amount employed is generally in the range of from about 1% to about 99%, preferably from about 10% to about 90%, most preferably from about 20% to about 80%.
  • the drugs useful for use in the present compositions are varied and many and include any agent which provides treatment of diseases of the oral cavity.
  • Some therapeutic agents which are amenable to delivery by this means and are potentially of value for periodontal therapy include (but are not limited to) antimicrobial agents/antibacterial agents such as iodine, sulfonamides, mercurials, bisbiguanides, or phenolics; antibiotics such as tetracycline, neomycin, kanamycin, metronidazole, or clindamycin; antiinflammatory agents such as aspirin, naproxen, ibuprofen, flurbiprofen, indomethacin, eugenol, or hydrocortisone; immune-suppressive or stimulatory agents such as methotrexate or levamasole; dentinal desensitizing agents such as strontium chloride or sodium fluoride; odor masking agents such as peppermint oil or chlorphyll; immune reagents such as
  • the drug active is used at a level of from about 1% to about 90%, preferably from about 5% to about 50% of the compositions.
  • compositions can be desirably tailored to provide sustained retention and slow release of one or more actives at the treatment site, by varying the ratios of components and, quantity of the product applied at the treatment site.
  • compositions of the present invention may include a variety of optional components.
  • Such components include, but are not limited to, surfactants, viscosity controlling agents, complexing agents, antioxidants, other polymers such as carboxymethyl cellulose, gums such as guar gum, waxes/oils such as castor wax, castor oil, glycerol, dibutyl phthalate and di(2-ethylhexyl phthalate) as well as many others. If used, these optional components comprise from about 0.1% to about 20%, preferably from about 0.5% to about 5% of the total composition.
  • the above composition can be prepared in a number of different ways.
  • One way is as follows: The monooleate is heated to about 5° C. The hydroxypropyl cellulose is then added in powdered form and dissolved. The drug is added and mixed until uniform. The mixture is then cooled and packaged.
  • compositions of the invention of this application are inserted into or around the periodontal pocket or gingival region, and are administered in the form of a gel which sets up.
  • the composition can be put into or around the pocket in any number of ways such as with a syringe.

Abstract

This invention relates to compositions and methods for treating diseases of the oral cavity in humans and lower animals using a glycerol monooleate gel for releasing drugs in the oral cavity.

Description

TECHNICAL FIELD
This invention relates to compositions for treating diseases of the oral cavity, which compositions are placed in or around the periodontal pocket. The invention also relates to methods of using the compositions in humans and lower animals suffering from such diseases.
Periodontal disease, for example, is a major cause of tooth loss in adults. Tooth loss from periodontal disease is a significant problem beginning at age 35, but even by age 15 it is estimated that about 4 out of 5 persons already have gingivitis and 4 out of 10 have periodontitis.
While good oral hygiene, as achieved by brushing the teeth with a cleansing dentifrice, may help reduce the incidence of periodontal disease, it does not necessarily prevent or eliminate its occurrence. This is because microorganisms contribute to both the initiation and progress of periodontal disease. Thus, in order to prevent or treat periodontal disease, these microorganisms must be suppressed by some means other than simple mechanical scrubbing. Towards this end, there has been a great deal of research aimed at developing therapeutic dentifrices, mouthwashes, and methods of treating periodontal disease which are effective in suppressing these microorganisms.
Recent developments in the art are directed toward delivering the therapeutic agent directly to the periodontal pocket, in some cases in a controlled release formulation. Gordon et al. have described the use of a drug-filled polymer hollow fiber. (J.M. Goodson et al., "Periodontal Therapy by Local Delivery of Tetracycline", J. Clin. Periodontal. 6, 83 (1979), J. Lindhe et al., "Local Tetracycline Delivery Using Hollow Fiber Devices in Periodontal Therapy", J. Clin. Periodontal. 6, 141 (1979) and R.L. Dunn et al., "Monolithic Fibers for Controlled Delivery of Tetracycline", in Proc. Ninth Int. Symposium on Controlled Release of Bioactive Materials, Ft. Lauderdale, FL, July (1982). This device is tied around a tooth and gently pressed below the margin of the gingiva so that it resides in the periodontal pocket, and is capable of delivering an effective dose of 2.5 micrograms of tetracycline per day per periodontal pocket for a prolonged period of a week or more. Similar results have been obtained by Coventry and Newman (J. Coventry and H. N. Newman, "Experimental Use of a Slow Release Device Employing Chlorhexidine Gluconate in Areas of Acute Periodontal Inflammation", J. Clin. Periodontal. 9, 129 (1982) and Addy et al. (M. Addy et al., "The Development and in vitro Evaluation of Acrylic Strips and Dialysis Tubing for Local Drug Delivery", J. Periodontal 53, 693 (1982) using acrylic strips 1 mm or more long, impregnated with chlorhexidine, tetracycline or metronidazole, which were inserted into the periodontal pocket with tweezers. Such a strip, formed from ethylcellulose impregnated with metronidazole, is disclosed by Loesche in U.S. Pat. No. 4,568,538 (February 1986). Another strip, employing a water soluble polymer of a particular elasticity and viscosity, is disclosed by Suzuki et al. in U.S. Pat. No. 4,569,837.
In addition to the above approaches, the prior art also discloses using putty-like compositions containing an antimicrobial for insertion into the periodontal pocket. See U.S. Pat. No. 4,650,665, Mar. 17, 1987 to Kronenthal et al., incorporated herein by reference.
Gel forming materials like hydroxypropyl methyl cellulose or pluronic F-127 polyol have been utilized in the past without success. It has been found that instead of using such hydrophilic or water soluble materials, desirable physical properties, convenience of placement and duration of retention can also be achieved by using materials that have limited water solubility. What is surprising, however, is that some of these materials are capable of absorbing water and undergoing increase in viscosity, providing a most desirable feature to treat disorders of the oral cavity.
The present inventor has discovered that compositions employing glycerol monooleate (monoolein) gels provide for easy placement in and around the periodontal pocket and good drug release.
When a material such as monoolein is compounded with an active agent and placed into or around the periodontal cavity, it absorbs water from the surrounding body fluid and becomes more viscous. Since monoolein is not miscible with water, it provides extended duration of retention at the site of treatment. The active agent is slowly released from the composition in a controlled manner over extended duration.
It is therefore an object of the present invention to provide monoolein compositions suitable for treating diseases of the oral cavity.
It is a further object of the present invention to provide such compositions using monoolein compositions which additionally employ a polymer.
It is still a further object of the present invention to provide a method of treating periodontal disease.
All percentages and ratios used in here are by weight unless otherwise indicated.
All measurements are made at 25° C. unless otherwise indicated.
SUMMARY OF INVENTION
The present invention relates to compositions and methods for treating diseases of the oral cavity by inserting the compositions into or around the periodontal pocket of humans and/or lower animals. The compositions comprise monooleate and an agent providing relief of diseases of the oral cavity.
DETAILED DESCRIPTION OF THE INVENTION
The essential as well as optional components of the compositions of this invention are described below.
Monoolein
The gelling agent useful with the present invention is a monooleate ester of glycerol (monoolein). Monoolein is an item of commerce and is available from C. P. Hall and Co. as CPH-362-N. This agent can easily be formulated with the drug active and be easily positioned into and around the periodontal pocket.
Monoolein comprises the bulk of the compositions of the present invention. The amount employed is generally in the range of from about 1% to about 99%, preferably from about 10% to about 90%, most preferably from about 20% to about 80%.
Drug Active
The drugs useful for use in the present compositions are varied and many and include any agent which provides treatment of diseases of the oral cavity. Some therapeutic agents which are amenable to delivery by this means and are potentially of value for periodontal therapy, include (but are not limited to) antimicrobial agents/antibacterial agents such as iodine, sulfonamides, mercurials, bisbiguanides, or phenolics; antibiotics such as tetracycline, neomycin, kanamycin, metronidazole, or clindamycin; antiinflammatory agents such as aspirin, naproxen, ibuprofen, flurbiprofen, indomethacin, eugenol, or hydrocortisone; immune-suppressive or stimulatory agents such as methotrexate or levamasole; dentinal desensitizing agents such as strontium chloride or sodium fluoride; odor masking agents such as peppermint oil or chlorphyll; immune reagents such as immunoglobulin or antigens; local anesthetic agents such as lidocaine or benzocaine; nutritional agents such as amino acids, essential fats, and vitamin C; antioxidants such as alphatocopherol and butylated hydroxy toluene; lipopolysaccharide complexing agents such as polymyxin; or peroxides such as urea peroxide. It is recognized that in certain forms of therapy, combinations of these agents in the same delivery system may be useful in order to obtain an optimal effect. Thus, for example, an antibacterial and an antiinflammatory agent may be combined in a single delivery system to provide combined effectiveness.
The drug active is used at a level of from about 1% to about 90%, preferably from about 5% to about 50% of the compositions.
Compositions can be desirably tailored to provide sustained retention and slow release of one or more actives at the treatment site, by varying the ratios of components and, quantity of the product applied at the treatment site.
Optional Components
In addition to the drug active, the compositions of the present invention may include a variety of optional components. Such components include, but are not limited to, surfactants, viscosity controlling agents, complexing agents, antioxidants, other polymers such as carboxymethyl cellulose, gums such as guar gum, waxes/oils such as castor wax, castor oil, glycerol, dibutyl phthalate and di(2-ethylhexyl phthalate) as well as many others. If used, these optional components comprise from about 0.1% to about 20%, preferably from about 0.5% to about 5% of the total composition.
METHOD OF MANUFACTURE
Methods of manufacturing the compositions of this invention are disclosed in the Examples.
The following Examples further describe and demonstrate the preferred embodiments within the scope of the present invention. The Examples are given solely for the purpose of illustration and are not to be constructed as limitations of the present invention as many variations thereof are possible without departing from its spirit and scope.
EXAMPLE I
The following is an exemplary composition of the present invention.
______________________________________                                    
                  Weight %                                                
______________________________________                                    
Tetracycline hydrochloride                                                
                    49.9                                                  
Hydroxypropyl cellulose                                                   
                     2.5                                                  
Glycerol monooleate 47.6                                                  
______________________________________                                    
The above composition can be prepared in a number of different ways. One way is as follows: The monooleate is heated to about 5° C. The hydroxypropyl cellulose is then added in powdered form and dissolved. The drug is added and mixed until uniform. The mixture is then cooled and packaged.
The compositions of the invention of this application are inserted into or around the periodontal pocket or gingival region, and are administered in the form of a gel which sets up. The composition can be put into or around the pocket in any number of ways such as with a syringe.
EXAMPLE II
Given below is another composition of the present invention:
______________________________________                                    
                 Wt. %                                                    
______________________________________                                    
Clindamycin phosphate                                                     
                   35                                                     
Hydroxypropyl cellulose                                                   
                    5                                                     
Lecithin           25                                                     
Glycerol monooleate                                                       
                   30                                                     
Polyethylene glycol-400                                                   
                    5                                                     
______________________________________                                    
EXAMPLE III
Given below is still another composition representative of the present invention:
______________________________________                                    
                 Wt. %                                                    
______________________________________                                    
Metronidazole      30                                                     
Hydroxypropyl cellulose                                                   
                    2                                                     
Lecithin           15                                                     
Glycerol monooleate                                                       
                   53                                                     
______________________________________                                    

Claims (12)

What is claimed is:
1. A composition suitable for insertion into or around the periodontal pocket of a person or lower animal suffering from diseases of the oral cavity consisting essentially of from about 1% to about 99% of monoolein and from about 1% to about 90% of a drug active suitable for treating diseases of the oral cavity selected from the group consisting of antiinflammatory agents, antimicrobials, antibiotics, peroxides, anesthetic agents and vitamins.
2. A composition according to claim 1 wherein the concentration of the drug active is from about 5% to about 50% and the active is selected from the tetracycline group of antibiotics.
3. A composition according to claim 2 which in addition contains another polymer.
4. A composition according to claim 3 wherein the polymer is carboxymethyl cellulose.
5. A method of treating diseases of the oral cavity in a person or lower animal suffering from such disease by placing a composition according to claim 1 into or around the periodontal pocket of said person or lower animal.
6. A method according to claim 5 wherein the composition has a monoolein concentration of from about 20% to about 80%.
7. A method according to claim 6 wherein the drug active is selected from the group consisting of antiinflammatory agents, antibiotics, antimicrobials, peroxides, anesthetic agents, vitamins and mixtures thereof.
8. A method according to claim 7 wherein the drug active is selected from the tetracycline group of antibiotics.
9. A method according to claim 7 wherein said composition additionally contains another polymer.
10. A method according to claim 7 wherein the drug active is an antiinflammatory agent.
11. A method according to claim 7 wherein the drug active is a bisbiguanide compound.
12. A composition suitable for insertion into or around the periodontal pocket of a person or lower animal suffering from diseases of the oral cavity consisting essentially of monoolein, a drug active suitable for treating diseases of the oral cavity, and a wax or oil.
US07/439,064 1989-11-17 1989-11-17 Sustained release compositions for treating periodontal disease Expired - Lifetime US5262164A (en)

Priority Applications (15)

Application Number Priority Date Filing Date Title
US07/439,064 US5262164A (en) 1989-11-17 1989-11-17 Sustained release compositions for treating periodontal disease
CA002029050A CA2029050C (en) 1989-11-17 1990-10-31 Sustained release compositions for treating periodontal disease
DE69025270T DE69025270T2 (en) 1989-11-17 1990-11-08 Use of monoolein in the treatment of the periodontal pocket
EP90312246A EP0429224B1 (en) 1989-11-17 1990-11-08 Use of monoolein in the treatment of the periodontal pocket
ES90312246T ES2082833T3 (en) 1989-11-17 1990-11-08 USE OF MONOOLEIN IN THE TREATMENT OF THE PERIODONTAL BAG.
DK90312246.3T DK0429224T3 (en) 1989-11-17 1990-11-08 Use of monoolein in the treatment of periodontal pockets
AT90312246T ATE133858T1 (en) 1989-11-17 1990-11-08 USE OF MONOOLEIN IN THE TREATMENT OF THE PERIODONTAL POCKET
EP95106829A EP0671175A3 (en) 1989-11-17 1990-11-08 Sustained release compositions for treating periodontal disease.
KR1019900018464A KR0156916B1 (en) 1989-11-17 1990-11-15 Sustained release compositions for treating periodontal disease
PT95896A PT95896B (en) 1989-11-17 1990-11-15 PROCESS FOR THE PREPARATION OF A DELAYED LIBERATION COMPOSITION FOR TREATMENT OF PERIODONTIC DISEASES
IE414990A IE72515B1 (en) 1989-11-17 1990-11-16 Use of monoolein in the treatment of the peridontal pocket
JP2311261A JPH03209313A (en) 1989-11-17 1990-11-16 Sustainably releasable therapeutic composition for treating gum infection
AU66678/90A AU648761B2 (en) 1989-11-17 1990-11-16 Sustained release compositions for treating periodontal disease
FI905682A FI98124C (en) 1989-11-17 1990-11-16 A process for preparing sustained release compositions
GR950403547T GR3018933T3 (en) 1989-11-17 1996-02-08 Use of monoolein in the treatment of the periodontal pocket

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/439,064 US5262164A (en) 1989-11-17 1989-11-17 Sustained release compositions for treating periodontal disease

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US5262164A true US5262164A (en) 1993-11-16

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Country Status (14)

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US (1) US5262164A (en)
EP (2) EP0429224B1 (en)
JP (1) JPH03209313A (en)
KR (1) KR0156916B1 (en)
AT (1) ATE133858T1 (en)
AU (1) AU648761B2 (en)
CA (1) CA2029050C (en)
DE (1) DE69025270T2 (en)
DK (1) DK0429224T3 (en)
ES (1) ES2082833T3 (en)
FI (1) FI98124C (en)
GR (1) GR3018933T3 (en)
IE (1) IE72515B1 (en)
PT (1) PT95896B (en)

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US5230895A (en) * 1990-05-01 1993-07-27 Copley Pharmaceutical Inc. Sustained released delivery system for use in the periodontal pocket
BR9612039A (en) * 1995-12-20 1999-02-09 Unilever Nv Use of an amphiphilic organic material and anti-sensitive toothpaste
GB9617001D0 (en) 1996-08-13 1996-09-25 Tillotts Pharma Ag Oral composition
GB9618964D0 (en) * 1996-09-11 1996-10-23 Tillotts Pharma Ag Oral composition
CA2286052A1 (en) * 1997-04-17 1998-10-29 Lise Sylvest Nielsen A novel bioadhesive drug delivery system based on liquid crystals
BE1011899A6 (en) * 1998-04-30 2000-02-01 Ucb Sa PHARMACEUTICAL USE gelling.
AU4825200A (en) * 1999-05-07 2000-11-21 Board Of Regents, The University Of Texas System Oral steroidal hormone compositions and methods of use
AU2001278516A1 (en) * 2000-08-07 2002-02-18 Unilever Plc Oral cosmetic composition comprising petroleum jelly enrobing an active agent
US7008646B2 (en) * 2001-02-20 2006-03-07 Patrick Thomas Spicer Cubic liquid crystalline compositions and methods for their preparation
GB2381449A (en) * 2001-10-31 2003-05-07 Smithkline Beecham Plc Oral hygiene compositions comprising an electron acceptor
BRPI0611560A2 (en) * 2005-03-18 2010-09-21 Lg Household & Health Care Ltd dental whitener
US20080219935A1 (en) * 2005-07-08 2008-09-11 Sang-Hoon Kwak Phase Transitive Breath Care Products
US8778386B2 (en) 2005-12-13 2014-07-15 Kimberly-Clark Worldwide, Inc. Anti-microbial substrates with peroxide treatment
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IE72515B1 (en) 1997-04-23
KR0156916B1 (en) 1998-11-16
KR910009242A (en) 1991-06-28
ES2082833T3 (en) 1996-04-01
IE904149A1 (en) 1991-05-22
GR3018933T3 (en) 1996-05-31

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