US650760A - Gelatin capsule. - Google Patents
Gelatin capsule. Download PDFInfo
- Publication number
- US650760A US650760A US73899399A US1899738993A US650760A US 650760 A US650760 A US 650760A US 73899399 A US73899399 A US 73899399A US 1899738993 A US1899738993 A US 1899738993A US 650760 A US650760 A US 650760A
- Authority
- US
- United States
- Prior art keywords
- capsule
- pepsin
- gelatin
- stomach
- pill
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000007903 gelatin capsule Substances 0.000 title description 4
- 239000002775 capsule Substances 0.000 description 17
- 102000057297 Pepsin A Human genes 0.000 description 13
- 108090000284 Pepsin A Proteins 0.000 description 13
- 229940111202 pepsin Drugs 0.000 description 13
- 239000006187 pill Substances 0.000 description 11
- 239000000203 mixture Substances 0.000 description 10
- 239000008273 gelatin Substances 0.000 description 9
- 229920000159 gelatin Polymers 0.000 description 9
- 108010010803 Gelatin Proteins 0.000 description 8
- 235000019322 gelatine Nutrition 0.000 description 8
- 235000011852 gelatine desserts Nutrition 0.000 description 8
- 210000002784 stomach Anatomy 0.000 description 8
- 239000003814 drug Substances 0.000 description 6
- 150000001875 compounds Chemical class 0.000 description 5
- 239000011248 coating agent Substances 0.000 description 4
- 238000000576 coating method Methods 0.000 description 4
- 230000029087 digestion Effects 0.000 description 3
- 229940079593 drug Drugs 0.000 description 3
- 239000007788 liquid Substances 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 2
- 241000661938 Capsus Species 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 238000010276 construction Methods 0.000 description 1
- 235000011389 fruit/vegetable juice Nutrition 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 1
Images
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/4841—Filling excipients; Inactive ingredients
- A61K9/4858—Organic compounds
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S206/00—Special receptacle or package
- Y10S206/819—Material
Definitions
- ranonmcx 1-1 ranonmcx 1-1.
- METCALF or FRANKLIN, ILLINOiS.
- This invention relates to improvements in gelatin capsules and gelatin-coated pills and tablets, and has especial reference to capsules, increasing their solubility when used in connection with compounds which they incase.
- the object of the invention is to provide a capsule and coating for pills which will be more soluble and susceptible to digestion when taken into the stomach than the ordinary capsule or gelatin-coated pill or tablet, as is now marketed.
- the invention consists of mixing in the gelatin composition while it is in a liquid state a' sufficient quantity of pepsin or other drug which will assist the stomach to digest the capsule-shell or coating of pill or tablet.
- Figure 1 is a section of the capsule.
- Fig. 2 is a similar View showing the application of the invention to pills.
- Fig. 3 is a sectional view of a capsule, showing another mode of applying my invention.
- Fig. at is a sectional View of a further modification of a capsule.
- FIG. 1 represents a capsule provided with a mixture of pepsin
- Fig. 2 the invention is applied to a pill, the mode of operation and advantages obtained being substantially the same.
- the mixture is first reduced by heat and water to a-liquid form and the composition thoroughly mixed. It is at this stage of the preparation of the composition that I put in a sufficient quantity of pepsin according to the intended purpose of the-capsule.
- the same principle is em ployed.
- the pill is prepared in the usual manner, after which it is rolled in a liquid composition of capsule-gelatin combined with pepsin, as before stated. I do not limit myself to the specific use of pepsin, as any analogous drug which can be mixed in with the composition without destroying or in any way affecting the gelatin can be substituted.
- the invention is extremely simple and of great value where it is of absolute necessity in many cases that the medicine within the capsule should reach the stomach and act immediately.
- the capsule-shell can be used to assist digestion a suflicient quantity of the pepsin having been mixed with the gelatin in its manufacture.
- the walls of the capsule are made double and a layer of pepsin is interposed, and in Fig. 41- the construction is substantially the same, except that a small opening, 4 is provided in the outer capsule, so as to permit the juices in the stomach to immediately coact with the pepsin between the Walls.
Description
Patented May 29, I900.
F. H. METCALF.
GELAT-IN CAPSULE. (Applica tion filed Dec. 2, 1399.
(No Model.)
wwmm
5L4 JV M THE NORRXS PETERS CO, PNOYO-UTHO. WASHINGTON. n. C
Fries.
ranonmcx 1-1. METCALF, or FRANKLIN, ILLINOiS.
GELATIN CAPSU LE.
S PECIFICATION forming part of Letters Patent No. 650,760, dated May 29, 1900.
Application filed December 2, 18991 $erial No.'738;993. (No infidel.)
To all whom it may concern.-
Be it known that I FREDERICK H. CALF, a citizen of the United States, residing at Franklin, in the county of Morgan and State of Illinois, have invented new and useful Im provements in Capsules; of which the following is a specification.
This invention relates to improvements in gelatin capsules and gelatin-coated pills and tablets, and has especial reference to capsules, increasing their solubility when used in connection with compounds which they incase.
The object of the invention is to provide a capsule and coating for pills which will be more soluble and susceptible to digestion when taken into the stomach than the ordinary capsule or gelatin-coated pill or tablet, as is now marketed.
The invention consists of mixing in the gelatin composition while it is in a liquid state a' sufficient quantity of pepsin or other drug which will assist the stomach to digest the capsule-shell or coating of pill or tablet.
Many other objects and advantages will be hereinafter referred to, and particularly pointed out in the claim.
In the drawings forming a part of this specification, Figure 1 is a section of the capsule. Fig. 2 is a similar View showing the application of the invention to pills. Fig. 3 is a sectional view of a capsule, showing another mode of applying my invention. Fig. at is a sectional View of a further modification of a capsule.
In the drawings, 1 represents a capsule provided with a mixture of pepsin In Fig. 2 the invention is applied to a pill, the mode of operation and advantages obtained being substantially the same.
It is a well-known fact that frequently capsules are not easily digestible and under some circumstances tend to deter the quick and active operation of the medicine after it reaches the stomach. It is the purpose of this invention to assist the stomach in reducing the capsule-shell when it incases a compound or the coating of pill or tablet. The proportion of pepsin mixed with the capsule orcoating of pill or tablet when used for this purpose will be such as to not aifect the medicine contained within it, but to cowork with it. A
sufficient quantity is used to quickly and eliec= tually reduce the capsule-shell or coating of pill or tablet immediately after it is taken into the stomach, so as to expose the compound to the quick motion of the system to which and for which it was intended;
I propose to make a capsule especially pre} pared to contain compounds intended to aid digestion. For such purposes a greater quantity of pepsin will be added to the gelatin mixture than would otherwise be added when the capsules are to be used for ordinary purposes. In such cases the pepsin not only as sists the stomach to digest the capsule, but also acts in conjunction with the compound to accomplish its mission.
In the manufacture of gelatin capsules the mixture is first reduced by heat and water to a-liquid form and the composition thoroughly mixed. It is at this stage of the preparation of the composition that I put in a sufficient quantity of pepsin according to the intended purpose of the-capsule. In applying the improvement to pills the same principle is em ployed. The pill is prepared in the usual manner, after which it is rolled in a liquid composition of capsule-gelatin combined with pepsin, as before stated. I do not limit myself to the specific use of pepsin, as any analogous drug which can be mixed in with the composition without destroying or in any way affecting the gelatin can be substituted.
, It will be seen that the invention is extremely simple and of great value where it is of absolute necessity in many cases that the medicine within the capsule should reach the stomach and act immediately. By mixing the pepsin in the composition as above described I have not only produced a novel means of assisting nature, but have provided something which can be produced cheaply and at the same time have not added any thing to the weight of the capsule-shell, nor have I mixed a drug with the gelatin which will in any way destroy any element of the composition.
In many cases the capsule-shell can be used to assist digestion a suflicient quantity of the pepsin having been mixed with the gelatin in its manufacture.
As shown in Fig. 3 the walls of the capsule are made double and a layer of pepsin is interposed, and in Fig. 41- the construction is substantially the same, except that a small opening, 4 is provided in the outer capsule, so as to permit the juices in the stomach to immediately coact with the pepsin between the Walls.
' Having thus described my invention, What I claim is- As an article of man u facture, a gelatin capsule having pepsin incorporated with its 00111' to position, as set forth.
In testimony whereof I have hereunto set my hand in the presence of two subscribing witnesses.
FREDERICK H. MEICALF.
\Vitnesses:
OHAs. A. BARNES, LENA C. ENGEL.
Priority Applications (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73899399A US650760A (en) | 1899-12-02 | 1899-12-02 | Gelatin capsule. |
US18307A US671804A (en) | 1899-12-02 | 1900-05-28 | Coated pill, &c. |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US73899399A US650760A (en) | 1899-12-02 | 1899-12-02 | Gelatin capsule. |
Publications (1)
Publication Number | Publication Date |
---|---|
US650760A true US650760A (en) | 1900-05-29 |
Family
ID=2719330
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US73899399A Expired - Lifetime US650760A (en) | 1899-12-02 | 1899-12-02 | Gelatin capsule. |
Country Status (1)
Country | Link |
---|---|
US (1) | US650760A (en) |
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2911338A (en) * | 1954-03-09 | 1959-11-03 | Abbott Lab | Capsules and method of producing |
US3285408A (en) * | 1964-10-16 | 1966-11-15 | Lilly Co Eli | Capsule with integral locking band |
US3403106A (en) * | 1965-07-12 | 1968-09-24 | Armour & Co | Buoyant soap cake and preparation thereof |
US3493652A (en) * | 1962-09-14 | 1970-02-03 | Charles W Hartman | Controlled release medicament |
US3639259A (en) * | 1969-04-09 | 1972-02-01 | Ncr Co | Enzymatic treatment of gelled proteinaceous film material |
US3943238A (en) * | 1972-11-01 | 1976-03-09 | Meija Seika Co., Ltd. | Method for the preparation of medicinal capsules |
US4115534A (en) * | 1976-08-19 | 1978-09-19 | Minnesota Mining And Manufacturing Company | In vitro diagnostic test |
US4169804A (en) * | 1976-08-19 | 1979-10-02 | Minnesota Mining And Manufacturing Company | Magnetically responsive composite microparticle |
US4261969A (en) * | 1979-05-03 | 1981-04-14 | World Health Organization | Controlled drug release composition |
US4609403A (en) * | 1984-03-12 | 1986-09-02 | Warner-Lambert Company | Foam soft gelatin capsules and their method of manufacture |
US5750145A (en) * | 1995-07-28 | 1998-05-12 | Bristol-Myers Squibb Company | Stable gelatin coated aspirin tablets |
-
1899
- 1899-12-02 US US73899399A patent/US650760A/en not_active Expired - Lifetime
Cited By (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2911338A (en) * | 1954-03-09 | 1959-11-03 | Abbott Lab | Capsules and method of producing |
US3493652A (en) * | 1962-09-14 | 1970-02-03 | Charles W Hartman | Controlled release medicament |
US3285408A (en) * | 1964-10-16 | 1966-11-15 | Lilly Co Eli | Capsule with integral locking band |
US3403106A (en) * | 1965-07-12 | 1968-09-24 | Armour & Co | Buoyant soap cake and preparation thereof |
US3639259A (en) * | 1969-04-09 | 1972-02-01 | Ncr Co | Enzymatic treatment of gelled proteinaceous film material |
US3943238A (en) * | 1972-11-01 | 1976-03-09 | Meija Seika Co., Ltd. | Method for the preparation of medicinal capsules |
US4115534A (en) * | 1976-08-19 | 1978-09-19 | Minnesota Mining And Manufacturing Company | In vitro diagnostic test |
US4169804A (en) * | 1976-08-19 | 1979-10-02 | Minnesota Mining And Manufacturing Company | Magnetically responsive composite microparticle |
US4261969A (en) * | 1979-05-03 | 1981-04-14 | World Health Organization | Controlled drug release composition |
US4609403A (en) * | 1984-03-12 | 1986-09-02 | Warner-Lambert Company | Foam soft gelatin capsules and their method of manufacture |
US5750145A (en) * | 1995-07-28 | 1998-05-12 | Bristol-Myers Squibb Company | Stable gelatin coated aspirin tablets |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US650760A (en) | Gelatin capsule. | |
US710060A (en) | Capsule for medicines. | |
US671804A (en) | Coated pill, &c. | |
GB191300392A (en) | Medicinal Preparation in Tablet Form. | |
US1746984A (en) | Vehicle for acetyl-salicylic acid tablets | |
US2870060A (en) | Stable encapsulated solution of a salt of a dialkyl sulfosuccinate | |
US1021674A (en) | Medicinal tablet. | |
US279166A (en) | William huffman | |
US132275A (en) | Improvement in medical compounds | |
US206676A (en) | Improvement in medical compounds | |
US152327A (en) | Improvement in medical compounds | |
USD50538S (en) | Design foe a candy tablet | |
US294687A (en) | Medical compound | |
USD43263S (en) | Design foe an advebtising-sign structure | |
US266778A (en) | Ments | |
Velasquez et al. | Precipitous resolution of type-A intramural hematoma with medical management in a patient with metastatic stage 4 renal cell carcinoma | |
US102788A (en) | Improved medical compound | |
US57561A (en) | Improved medicine | |
USD52688S (en) | Design for | |
AT35705B (en) | Process for the production of easily soluble gelatin capsules. | |
Kulkarni | Clopidogrel in cardiovascular disorders | |
US327233A (en) | caenrick | |
US192590A (en) | In hog-cholera compounds | |
USD49123S (en) | Design for a bottle-stopper | |
US54492A (en) | Improved compound sirup |