WO1997047323A3 - Chitosan drug delivery system - Google Patents

Chitosan drug delivery system Download PDF

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Publication number
WO1997047323A3
WO1997047323A3 PCT/US1997/010028 US9710028W WO9747323A3 WO 1997047323 A3 WO1997047323 A3 WO 1997047323A3 US 9710028 W US9710028 W US 9710028W WO 9747323 A3 WO9747323 A3 WO 9747323A3
Authority
WO
WIPO (PCT)
Prior art keywords
drug delivery
chitosan
compositions
delivery system
drug
Prior art date
Application number
PCT/US1997/010028
Other languages
French (fr)
Other versions
WO1997047323A2 (en
Inventor
Joseph S Podolski
Kuang T Hsu
Gurpreet Singh
Original Assignee
Zonagen Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zonagen Inc filed Critical Zonagen Inc
Priority to JP10501772A priority Critical patent/JPH10513202A/en
Priority to AU34814/97A priority patent/AU3481497A/en
Priority to EP97931091A priority patent/EP0843559A2/en
Publication of WO1997047323A2 publication Critical patent/WO1997047323A2/en
Publication of WO1997047323A3 publication Critical patent/WO1997047323A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin

Abstract

The present invention relates generally to a novel drug delivery composition. More specifically, the invention relates to a drug delivery compositions comprising an iron/chitosan particulate in combination with a desired drug, a chitosan-formulated drug compound, or chitosan/oil-surfactant in combination with a desired substance. The invention also contemplates methods for drug delivery involving the compositions as well as methods for producing the compositions.
PCT/US1997/010028 1996-06-11 1997-06-11 Chitosan drug delivery system WO1997047323A2 (en)

Priority Applications (3)

Application Number Priority Date Filing Date Title
JP10501772A JPH10513202A (en) 1996-06-11 1997-06-11 Chitosan drug delivery system
AU34814/97A AU3481497A (en) 1996-06-11 1997-06-11 Chitosan drug delivery system
EP97931091A EP0843559A2 (en) 1996-06-11 1997-06-11 Chitosan drug delivery system

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1954396P 1996-06-11 1996-06-11
US60/019,543 1996-06-11

Publications (2)

Publication Number Publication Date
WO1997047323A2 WO1997047323A2 (en) 1997-12-18
WO1997047323A3 true WO1997047323A3 (en) 1998-04-23

Family

ID=21793774

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/010028 WO1997047323A2 (en) 1996-06-11 1997-06-11 Chitosan drug delivery system

Country Status (6)

Country Link
EP (1) EP0843559A2 (en)
JP (1) JPH10513202A (en)
CN (1) CN1198100A (en)
AU (1) AU3481497A (en)
CA (1) CA2228251A1 (en)
WO (1) WO1997047323A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE19940794A1 (en) * 1999-08-27 2001-03-01 Lohmann Therapie Syst Lts Pharmaceutical preparation
FR2854072B1 (en) * 2003-04-23 2006-08-04 Centre Nat Rech Scient VECTOR FOR ORAL ADMINISTRATION
US7588774B2 (en) 2003-05-12 2009-09-15 Becton, Dickinson And Company Molecules enhancing dermal delivery of influenza vaccines
CA2621641C (en) * 2005-09-15 2014-10-21 Council Of Scientific And Industrial Research Ph sensitive nanoparticle formulation for oral delivery of proteins/peptides
EP1797870A1 (en) * 2005-12-14 2007-06-20 The Jordanian Pharmaceutical Manufacturing Co. Oral delivery of protein drugs using microemulsion
EP2042166A1 (en) * 2007-09-25 2009-04-01 The Jordanian Pharmaceutical Manufacturing Co. Nanocapsules for oral delivery of proteins
US9161901B2 (en) 2008-02-21 2015-10-20 University Of South Florida Nanoparticle targeted drug delivery to the lungs using extra-testicular Sertoli cells
WO2013152314A1 (en) * 2012-04-06 2013-10-10 University Of North Texas A facile method for making non-toxic biomedical compositions comprising hybrid metal-polymer microparticles
CN112999198A (en) * 2021-03-10 2021-06-22 中农宠物营养研究院(江苏)有限公司 Synbiotic microcapsule capable of resisting gastric acid and achieving intestinal tract targeted release based on chitosan-Fe coating and preparation method thereof

Citations (18)

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Publication number Priority date Publication date Assignee Title
EP0194497A2 (en) * 1985-03-14 1986-09-17 Etablissement Texcontor Chitosan derivatives in the form of coordinated complexes with ferrous ions
EP0200902A2 (en) * 1985-03-26 1986-11-12 Fujisawa Pharmaceutical Co., Ltd. Drug carrier and pharmaceutical preparation comprising it
JPS6281328A (en) * 1985-10-03 1987-04-14 Rooman Kogyo:Kk Long-acting drug preparation for oral administration
JPS63254102A (en) * 1985-03-14 1988-10-20 エタブリスメント・エクスコントール Ferrous ion ligand complex like chitosan derivatives
EP0392396A2 (en) * 1989-04-10 1990-10-17 Etablissement TEXCONTOR Complexes of iron or other metals with sulphonated derivatives of chitosan
EP0454383A1 (en) * 1990-04-23 1991-10-30 Aicello Chemical Co., Ltd. Large intestinal dissociative polypeptide series oral formulation
EP0466566A2 (en) * 1990-07-10 1992-01-15 Shin-Etsu Chemical Co., Ltd. Coated solid medicament form having releasebility in large intestine
JPH04247026A (en) * 1991-01-31 1992-09-03 Teikoku Seiyaku Co Ltd Oral agent disintegrating in lower part of digestive tract
JPH04327528A (en) * 1991-04-23 1992-11-17 Lion Corp S0lid pharmaceutical for oral use
EP0526862A1 (en) * 1991-08-06 1993-02-10 VECTORPHARMA INTERNATIONAL S.p.A. Solid pharmaceutical compositions for oral administration with prolonged gastric residence
EP0576675A1 (en) * 1991-03-25 1994-01-05 Fujisawa Pharmaceutical Co., Ltd. Long-acting pharmaceutical preparation
JPH06256166A (en) * 1993-01-06 1994-09-13 ▲寛▼治 ▲高▼田 Pharmaceutical preparation for controlling release of medicine
EP0619322A2 (en) * 1993-04-07 1994-10-12 Pfizer Inc. Prolonged delivery of peptides
EP0622077A1 (en) * 1993-04-22 1994-11-02 Takeda Chemical Industries, Ltd. Angiotensin II antagonists as a prophylactic or therapeutic drug for renal diseases
JPH07258087A (en) * 1994-03-25 1995-10-09 Toko Yakuhin Kogyo Kk Allopurinol gargarisma
EP0687466A1 (en) * 1994-06-16 1995-12-20 Tapuach Natural Technologies (1993) Ltd. Homeopathic formulations
EP0705607A2 (en) * 1994-10-07 1996-04-10 Takeda Chemical Industries, Ltd. Condensed seven- or eight-membered heterocyclic compounds useful as antihypertriglyceridemic agents
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides

Patent Citations (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS63254102A (en) * 1985-03-14 1988-10-20 エタブリスメント・エクスコントール Ferrous ion ligand complex like chitosan derivatives
EP0194497A2 (en) * 1985-03-14 1986-09-17 Etablissement Texcontor Chitosan derivatives in the form of coordinated complexes with ferrous ions
EP0200902A2 (en) * 1985-03-26 1986-11-12 Fujisawa Pharmaceutical Co., Ltd. Drug carrier and pharmaceutical preparation comprising it
JPS6281328A (en) * 1985-10-03 1987-04-14 Rooman Kogyo:Kk Long-acting drug preparation for oral administration
EP0392396A2 (en) * 1989-04-10 1990-10-17 Etablissement TEXCONTOR Complexes of iron or other metals with sulphonated derivatives of chitosan
EP0454383A1 (en) * 1990-04-23 1991-10-30 Aicello Chemical Co., Ltd. Large intestinal dissociative polypeptide series oral formulation
EP0466566A2 (en) * 1990-07-10 1992-01-15 Shin-Etsu Chemical Co., Ltd. Coated solid medicament form having releasebility in large intestine
JPH04247026A (en) * 1991-01-31 1992-09-03 Teikoku Seiyaku Co Ltd Oral agent disintegrating in lower part of digestive tract
EP0576675A1 (en) * 1991-03-25 1994-01-05 Fujisawa Pharmaceutical Co., Ltd. Long-acting pharmaceutical preparation
JPH04327528A (en) * 1991-04-23 1992-11-17 Lion Corp S0lid pharmaceutical for oral use
EP0526862A1 (en) * 1991-08-06 1993-02-10 VECTORPHARMA INTERNATIONAL S.p.A. Solid pharmaceutical compositions for oral administration with prolonged gastric residence
JPH06256166A (en) * 1993-01-06 1994-09-13 ▲寛▼治 ▲高▼田 Pharmaceutical preparation for controlling release of medicine
EP0619322A2 (en) * 1993-04-07 1994-10-12 Pfizer Inc. Prolonged delivery of peptides
EP0622077A1 (en) * 1993-04-22 1994-11-02 Takeda Chemical Industries, Ltd. Angiotensin II antagonists as a prophylactic or therapeutic drug for renal diseases
US5514670A (en) * 1993-08-13 1996-05-07 Pharmos Corporation Submicron emulsions for delivery of peptides
JPH07258087A (en) * 1994-03-25 1995-10-09 Toko Yakuhin Kogyo Kk Allopurinol gargarisma
EP0687466A1 (en) * 1994-06-16 1995-12-20 Tapuach Natural Technologies (1993) Ltd. Homeopathic formulations
EP0705607A2 (en) * 1994-10-07 1996-04-10 Takeda Chemical Industries, Ltd. Condensed seven- or eight-membered heterocyclic compounds useful as antihypertriglyceridemic agents

Non-Patent Citations (10)

* Cited by examiner, † Cited by third party
Title
CHANDY T. ET AL.: "Biodegradable chitosan matrix for the controlled release of steroids", BIOMATER. ARTIF. CELLS IMMOBILIZATION BIOTECHNOL., vol. 19, no. 4, 1991, USA, pages 745 - 760, XP002055071 *
DATABASE WPI Section Ch Week 8720, Derwent World Patents Index; Class A96, AN 87-140921, XP002055074 *
DATABASE WPI Section Ch Week 8848, Derwent World Patents Index; Class A96, AN 88-341892, XP002048975 *
DATABASE WPI Section Ch Week 9242, Derwent World Patents Index; Class A96, AN 92-343803, XP002055076 *
DATABASE WPI Section Ch Week 9252, Derwent World Patents Index; Class B07, AN 92-430051, XP002055077 *
DATABASE WPI Section Ch Week 9441, Derwent World Patents Index; Class A96, AN 94-329906, XP002055075 *
DATABASE WPI Section Ch Week 9549, Derwent World Patents Index; Class A96, AN 95-379983, XP002055073 *
GEARY R.S. ET AL.: "Vancomycin and insulin used as models for oral delivery of peptides", J.CONTROL.RELEASE, vol. 23, no. 1, January 1993 (1993-01-01), NETHERLANDS, pages 65 - 74, XP000332069 *
HARI,P.R. ET AL.: "Chitosan/calcium-alginate beads for oral delivery of insulin", J.APPL.POLYM.SCI., vol. 59, no. 11, 1996, pages 1795 - 1801, XP002055072 *
HIROFUMI TAKEUCHI ET AL.: "Enteral absorption in rats from mucoadhesive chitosan-coated liposomes", PHARM. RES., vol. 13, no. 6, June 1996 (1996-06-01), USA, pages 896 - 901, XP002055070 *

Also Published As

Publication number Publication date
CA2228251A1 (en) 1997-12-18
WO1997047323A2 (en) 1997-12-18
JPH10513202A (en) 1998-12-15
CN1198100A (en) 1998-11-04
AU3481497A (en) 1998-01-07
EP0843559A2 (en) 1998-05-27

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