WO1998009597A3 - Cushioning beads and tablet comprising the same capable of forming a suspension - Google Patents

Cushioning beads and tablet comprising the same capable of forming a suspension Download PDF

Info

Publication number
WO1998009597A3
WO1998009597A3 PCT/US1997/015573 US9715573W WO9809597A3 WO 1998009597 A3 WO1998009597 A3 WO 1998009597A3 US 9715573 W US9715573 W US 9715573W WO 9809597 A3 WO9809597 A3 WO 9809597A3
Authority
WO
WIPO (PCT)
Prior art keywords
beads
biologically active
tablets
active ingredient
cushioning
Prior art date
Application number
PCT/US1997/015573
Other languages
French (fr)
Other versions
WO1998009597A2 (en
Inventor
Yacoub S Habib
Ralph F Shangraw
Larry L Augsburger
Original Assignee
Univ Maryland
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Maryland filed Critical Univ Maryland
Priority to AU41814/97A priority Critical patent/AU4181497A/en
Publication of WO1998009597A2 publication Critical patent/WO1998009597A2/en
Publication of WO1998009597A3 publication Critical patent/WO1998009597A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01J—CHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
    • B01J13/00—Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
    • B01J13/02—Making microcapsules or microballoons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose

Abstract

Cushioning beads comprising microcrystalline cellulose and a disintegrant (preferably croscarmellose sodium) are disclosed. The cushioning beads are prepared by extrusion-spheronization, followed by freeze-drying. Also disclosed are water-dispersible tablets having high tensile strength, comprising the cushioning beads and biologically active ingredient-loaded beads, wherein optionally, the tablets can contain a viscosity enhancer in the form of separate beads, or as a component of the biologically active ingredient-loaded beads such that viscosity is rapidly generated when the tablets come in contact with water, and a homogeneous suspension is formed, which can be easily swallowed by children and the elderly, with minimal effect on the biologically active ingredient release properties. The tablets are useful for sustained delivery of large doses of biologically active ingredients where swallowing of a large tablet or capsule poses a problem.
PCT/US1997/015573 1996-09-06 1997-09-04 Cushioning beads and tablet comprising the same capable of forming a suspension WO1998009597A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU41814/97A AU4181497A (en) 1996-09-06 1997-09-04 Cushioning beads and tablet comprising the same capable of forming a suspension

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/709,415 1996-09-06
US08/709,415 US5780055A (en) 1996-09-06 1996-09-06 Cushioning beads and tablet comprising the same capable of forming a suspension

Publications (2)

Publication Number Publication Date
WO1998009597A2 WO1998009597A2 (en) 1998-03-12
WO1998009597A3 true WO1998009597A3 (en) 2001-06-28

Family

ID=24849759

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/015573 WO1998009597A2 (en) 1996-09-06 1997-09-04 Cushioning beads and tablet comprising the same capable of forming a suspension

Country Status (3)

Country Link
US (1) US5780055A (en)
AU (1) AU4181497A (en)
WO (1) WO1998009597A2 (en)

Families Citing this family (69)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030138485A1 (en) * 1998-01-14 2003-07-24 Daiichi Pharmaceutical Co., Ltd. Disintegrant
US6365185B1 (en) * 1998-03-26 2002-04-02 University Of Cincinnati Self-destructing, controlled release peroral drug delivery system
AU4288599A (en) * 1998-07-01 2000-01-24 Sun Pharmaceutical Industries Ltd. Stable pharmaceutical compositions of thieno (3,2-c) pyridine derivatives
US6126967A (en) * 1998-09-03 2000-10-03 Ascent Pediatrics Extended release acetaminophen particles
US6254891B1 (en) * 1998-09-03 2001-07-03 Ascent Pediatrics, Inc. Extended release acetaminophen
US5997905A (en) * 1998-09-04 1999-12-07 Mcneil-Ppc Preparation of pharmaceutically active particles
US6531152B1 (en) 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
US6160165A (en) * 1998-12-10 2000-12-12 Aesgen, Inc. Method for preparation of disodium pamidronate
US6794536B1 (en) 1998-12-10 2004-09-21 Aesqen, Inc. Method for preparation of disodium pamidronate
US20090060995A1 (en) 2005-01-13 2009-03-05 Kamalinder Kaur Singh Dispersible sustained release pharmaceutical compositions
CA2360938C (en) * 1999-02-02 2008-01-08 Warren Oliver Haggard Controlled release composite
US6632451B2 (en) 1999-06-04 2003-10-14 Dexcel Pharma Technologies Ltd. Delayed total release two pulse gastrointestinal drug delivery system
EP1228125A4 (en) * 1999-09-14 2009-09-02 Smithkline Beecham Corp Process for making aqueous coated beadlets
GB9921933D0 (en) 1999-09-17 1999-11-17 Univ Gent Solid shaped articles comprising biologically active substances and a method for their production
KR100329685B1 (en) * 1999-09-17 2002-03-25 강덕영 Quick Dispersible Formulation with Acetaminophen Tablet and Its process
DE10003757A1 (en) * 2000-01-28 2001-08-02 Knoll Ag Ibuprofen drug preparation
IL151475A0 (en) * 2000-03-30 2003-04-10 Bristol Myers Squibb Co Beadlets containing stavudine
FR2807973B1 (en) 2000-04-21 2002-11-15 Filtrauto VEHICLE INTERIOR AIR FILTER, VEHICLE COMPRISING SUCH A FILTER, AND MANUFACTURING METHOD
US6623756B1 (en) * 2000-04-27 2003-09-23 Noveon Ip Holdings Corp. Directly compressed solid dosage articles
US6258343B1 (en) * 2000-08-15 2001-07-10 Colgate-Palmolive Company Method for encapsulating reactive dental agents
CA2372450A1 (en) * 2001-05-10 2001-09-19 Pharmaceutical Partners Of Canada Inc. Liquid injectable formulation of disodium pamidronate
US8101209B2 (en) 2001-10-09 2012-01-24 Flamel Technologies Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles
FR2830447B1 (en) * 2001-10-09 2004-04-16 Flamel Tech Sa MICROPARTICULAR ORAL GALENIC FORM FOR DELAYED AND CONTROLLED RELEASE OF PHARMACEUTICAL ACTIVE INGREDIENTS
SE0103613D0 (en) * 2001-10-30 2001-10-30 Astrazeneca Ab Novel formulation
IL164221A0 (en) * 2002-04-09 2005-12-18 Flamel Tech Sa Oral pharmaceutical formulation in the form of aqueous suspension of microcapsules for modified release of amoxicillim
EP1492511B3 (en) 2002-04-09 2012-05-02 Flamel Technologies Oral pharmaceutical formulation in the form of aqueous suspension for modified release of active principle(s)
US7125563B2 (en) * 2002-04-12 2006-10-24 Dava Pharmaceuticals, Inc. Sustained release pharmaceutical preparations and methods for producing the same
US6958161B2 (en) 2002-04-12 2005-10-25 F H Faulding & Co Limited Modified release coated drug preparation
WO2003091290A1 (en) * 2002-04-23 2003-11-06 Boehringer Ingelheim Pharmaceuticals, Inc. Method for reduction of residual organic solvent in carbomer
US20050020613A1 (en) * 2002-09-20 2005-01-27 Alpharma, Inc. Sustained release opioid formulations and method of use
FR2845289B1 (en) * 2002-10-04 2004-12-03 Ethypharm Sa SPHEROIDS, PREPARATION METHOD AND PHARMACEUTICAL COMPOSITIONS.
WO2004060354A1 (en) * 2002-12-31 2004-07-22 Augsburger Larry L Methods for making pharmaceutical dosage forms containing active cushioning components
US20040161459A1 (en) * 2002-12-31 2004-08-19 Ngoc Do Fast-dissolve tablet technology
WO2004087175A1 (en) * 2003-04-04 2004-10-14 Pharmacia Corporation Oral extended release compressed tablets of multiparticulates
US6959588B2 (en) * 2003-06-19 2005-11-01 Schlumberger Technology Corporation Couette device and method to study solids deposition from flowing fluids
EP2112920B1 (en) 2003-06-26 2018-07-25 Intellipharmaceutics Corp. Proton pump-inhibitor-containing capsules which comprise subunits differently structured for a delayed release of the active ingredient
CA2533150C (en) * 2003-07-25 2013-03-12 Warner Chilcott Company, Inc. A doxycycline metal complex in a solid dosage form
WO2005061088A1 (en) * 2003-12-22 2005-07-07 Finlay Warren H Powder formation by atmospheric spray-freeze drying
US7207505B2 (en) * 2004-06-04 2007-04-24 Bender Martin P Method for producing small granules
US20070224269A1 (en) * 2004-06-10 2007-09-27 Rubino Orapin P Controlled Release Pharmaceutical Formulation
US8394409B2 (en) 2004-07-01 2013-03-12 Intellipharmaceutics Corp. Controlled extended drug release technology
US10624858B2 (en) 2004-08-23 2020-04-21 Intellipharmaceutics Corp Controlled release composition using transition coating, and method of preparing same
DE602005022462D1 (en) * 2004-09-20 2010-09-02 Ltb4 Sweden Ab STABILIZED LEUKOTRIEN B4 (LTB4) PHARMACEUTICAL
JP5235416B2 (en) * 2005-01-21 2013-07-10 ワーナー・チルコット・カンパニー・エルエルシー Tetracycline metal complexes in solid dosage forms.
US20060263429A1 (en) 2005-05-20 2006-11-23 Hengsheng Feng Compressible mixture, compressed pharmaceutical compositions, and method of preparation thereof
WO2006133733A1 (en) * 2005-06-13 2006-12-21 Flamel Technologies Oral dosage form comprising an antimisuse system
US8652529B2 (en) 2005-11-10 2014-02-18 Flamel Technologies Anti-misuse microparticulate oral pharmaceutical form
FR2892937B1 (en) * 2005-11-10 2013-04-05 Flamel Tech Sa MICROPARTICULAR ORAL PHARMACEUTICAL FORM ANTI-MEASURING
US8685478B2 (en) 2005-11-21 2014-04-01 Philip Morris Usa Inc. Flavor pouch
US10064828B1 (en) 2005-12-23 2018-09-04 Intellipharmaceutics Corp. Pulsed extended-pulsed and extended-pulsed pulsed drug delivery systems
CN101453993A (en) 2006-04-03 2009-06-10 伊萨·奥迪迪 Controlled release delivery device comprising an organosol coat
US10960077B2 (en) 2006-05-12 2021-03-30 Intellipharmaceutics Corp. Abuse and alcohol resistant drug composition
US8637076B2 (en) * 2006-06-01 2014-01-28 Cima Labs Inc. Prednisolone salt formulations
WO2008140772A2 (en) * 2007-05-08 2008-11-20 Hercules Incorporated Robust rapid disintegration tablet formulation
US8424541B2 (en) 2007-07-16 2013-04-23 Philip Morris Usa Inc. Tobacco-free oral flavor delivery pouch product
WO2009010881A2 (en) * 2007-07-16 2009-01-22 Philip Morris Products S.A. Oral pouch products with immobilized flavorant particles
KR101109633B1 (en) * 2007-08-03 2012-01-31 제이더블유중외제약 주식회사 Composition for manufacturing orally disintegrating dosage forms, for protecting the coating of active substance
EP2203174A4 (en) * 2007-09-19 2010-09-29 Combinatorx Inc Therapeutic regimens for the treatment of immunoinflammatory disorders
WO2010017056A1 (en) * 2008-08-07 2010-02-11 Merck & Co., Inc. Orally administered solid formulations containing a hydrophobic drug and tpgs
DE102008048729A1 (en) * 2008-09-24 2010-03-25 Add Technologies Ltd Advanced Drug Delivery Multiparticulate tablets and process for their preparation
PL2378883T3 (en) * 2008-12-04 2016-06-30 Intec Pharma Ltd Zaleplon gastroretentive drug delivery system
US8747562B2 (en) * 2009-10-09 2014-06-10 Philip Morris Usa Inc. Tobacco-free pouched product containing flavor beads providing immediate and long lasting flavor release
CA2781089C (en) * 2009-11-19 2015-01-27 Nippon Soda Co., Ltd. Reduction treatment method for ballast water
CN102762198A (en) * 2010-05-15 2012-10-31 欢腾生命科学有限公司 Multi-unit compositions
US9119793B1 (en) 2011-06-28 2015-09-01 Medicis Pharmaceutical Corporation Gastroretentive dosage forms for doxycycline
KR20130076015A (en) * 2011-12-28 2013-07-08 주식회사 삼양바이오팜 Highly robust fast disintegrating tablet and process for manufacturing the same
EP2841057B1 (en) 2012-04-25 2019-03-20 SPI Pharma, INC. Crystalline microspheres and the process for manufacturing the same
US10842802B2 (en) 2013-03-15 2020-11-24 Medicis Pharmaceutical Corporation Controlled release pharmaceutical dosage forms
EP3043779B1 (en) 2013-09-13 2018-05-16 R.P. Scherer Technologies, LLC Encased-pellet tablets

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049394A (en) * 1987-09-11 1991-09-17 E. R. Squibb & Sons, Inc. Pharmaceutical composition containing high drug load and method for preparing same

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8628359D0 (en) * 1986-11-27 1986-12-31 Zyma Sa Galenical formulation
DK130287D0 (en) * 1987-03-13 1987-03-13 Benzon As Alfred ORAL PREPARATION
EP0418596A3 (en) * 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
US5643591A (en) * 1991-01-16 1997-07-01 Fmc Corporation Solid dosage forms

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5049394A (en) * 1987-09-11 1991-09-17 E. R. Squibb & Sons, Inc. Pharmaceutical composition containing high drug load and method for preparing same

Also Published As

Publication number Publication date
US5780055A (en) 1998-07-14
AU4181497A (en) 1998-03-26
WO1998009597A2 (en) 1998-03-12

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