WO1998024412A3 - Compounds useful against diseases of the colon and methods for orally administering same - Google Patents

Compounds useful against diseases of the colon and methods for orally administering same Download PDF

Info

Publication number
WO1998024412A3
WO1998024412A3 PCT/US1997/022352 US9722352W WO9824412A3 WO 1998024412 A3 WO1998024412 A3 WO 1998024412A3 US 9722352 W US9722352 W US 9722352W WO 9824412 A3 WO9824412 A3 WO 9824412A3
Authority
WO
WIPO (PCT)
Prior art keywords
colon
methods
compounds useful
orally administering
against diseases
Prior art date
Application number
PCT/US1997/022352
Other languages
French (fr)
Other versions
WO1998024412A2 (en
Inventor
Michael Groves
Original Assignee
Univ Pennsylvania
Michael Groves
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Pennsylvania, Michael Groves filed Critical Univ Pennsylvania
Publication of WO1998024412A2 publication Critical patent/WO1998024412A2/en
Publication of WO1998024412A3 publication Critical patent/WO1998024412A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)

Abstract

This invention is an enteric-coated granular formulation capable of targeting or persisting in the colonic region and a method for using the formulation to treat disorders of the colon wall.
PCT/US1997/022352 1996-12-05 1997-12-03 Compounds useful against diseases of the colon and methods for orally administering same WO1998024412A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US3323596P 1996-12-05 1996-12-05
US60/033,235 1996-12-05

Publications (2)

Publication Number Publication Date
WO1998024412A2 WO1998024412A2 (en) 1998-06-11
WO1998024412A3 true WO1998024412A3 (en) 1998-11-26

Family

ID=21869269

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1997/022352 WO1998024412A2 (en) 1996-12-05 1997-12-03 Compounds useful against diseases of the colon and methods for orally administering same

Country Status (1)

Country Link
WO (1) WO1998024412A2 (en)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU766293B2 (en) * 1998-11-27 2003-10-16 Kanji Takada An oral formulation for gastrointestinal drug delivery
EP1284137B1 (en) * 2000-05-26 2010-12-01 TAKADA, Kanji Nonoral preparation having three-layer structure
DE10120092B4 (en) * 2001-04-25 2008-03-20 Lts Lohmann Therapie-Systeme Ag Gastro-resistant device for the release of mucoadhesive active substance carriers and method for the production of the enteric device
CN102813654A (en) * 2002-04-05 2012-12-12 欧洲凯尔蒂克公司 Matrix for sustained, invariant and independent release of active compounds
CN108066296B (en) * 2016-11-11 2020-11-17 南京益恒寿生命科技有限公司 Colon targeting composition containing biological active components and application thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077956A1 (en) * 1981-10-15 1983-05-04 Tanabe Seiyaku Co., Ltd. Enteric microcapsules and process for the preparation thereof
EP0250374A1 (en) * 1986-06-17 1987-12-23 RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. Therapeutic system for controlled release of drugs
WO1996029058A1 (en) * 1995-03-21 1996-09-26 Orion-Yhtymä Oy Peroral composition for controlled release in the lower gastrointestinal tract

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0077956A1 (en) * 1981-10-15 1983-05-04 Tanabe Seiyaku Co., Ltd. Enteric microcapsules and process for the preparation thereof
EP0250374A1 (en) * 1986-06-17 1987-12-23 RECORDATI INDUSTRIA CHIMICA E FARMACEUTICA S.p.a. Therapeutic system for controlled release of drugs
WO1996029058A1 (en) * 1995-03-21 1996-09-26 Orion-Yhtymä Oy Peroral composition for controlled release in the lower gastrointestinal tract

Also Published As

Publication number Publication date
WO1998024412A2 (en) 1998-06-11

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