WO1999059544A3 - Orally disintegrable tablets - Google Patents

Orally disintegrable tablets Download PDF

Info

Publication number
WO1999059544A3
WO1999059544A3 PCT/JP1999/002548 JP9902548W WO9959544A3 WO 1999059544 A3 WO1999059544 A3 WO 1999059544A3 JP 9902548 W JP9902548 W JP 9902548W WO 9959544 A3 WO9959544 A3 WO 9959544A3
Authority
WO
WIPO (PCT)
Prior art keywords
administered
orally disintegrable
fine granules
average particle
particle diameter
Prior art date
Application number
PCT/JP1999/002548
Other languages
French (fr)
Other versions
WO1999059544A9 (en
WO1999059544A2 (en
Inventor
Toshihiro Shimizu
Shuji Morimoto
Tetsuro Tabata
Original Assignee
Takeda Chemical Industries Ltd
Toshihiro Shimizu
Shuji Morimoto
Tetsuro Tabata
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27518561&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=WO1999059544(A3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority to DE69934505T priority Critical patent/DE69934505T2/en
Priority to KR1020047021546A priority patent/KR101032289B1/en
Priority to DK99919614T priority patent/DK1121103T3/en
Priority to AU37316/99A priority patent/AU3731699A/en
Priority to EP99919614A priority patent/EP1121103B1/en
Priority to CA002323680A priority patent/CA2323680C/en
Priority to US09/355,781 priority patent/US6328994B1/en
Application filed by Takeda Chemical Industries Ltd, Toshihiro Shimizu, Shuji Morimoto, Tetsuro Tabata filed Critical Takeda Chemical Industries Ltd
Publication of WO1999059544A2 publication Critical patent/WO1999059544A2/en
Publication of WO1999059544A3 publication Critical patent/WO1999059544A3/en
Priority to HK01106717A priority patent/HK1036401A1/en
Priority to US10/017,755 priority patent/US7431942B2/en
Priority to CY20071100020T priority patent/CY1105908T1/en
Publication of WO1999059544A9 publication Critical patent/WO1999059544A9/en
Priority to US12/151,572 priority patent/US7875292B2/en
Priority to US12/967,858 priority patent/US20110081412A1/en
Priority to US14/287,740 priority patent/US9901546B2/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A61K9/0056—Mouth soluble or dispersible forms; Suckable, eatable, chewable coherent forms; Forms rapidly disintegrating in the mouth; Lozenges; Lollipops; Bite capsules; Baked products; Baits or other oral forms for animals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1611—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Abstract

An orally disintegrable tablet, of the present invention, which comprises (i) fine granules having an average particle diameter of 400 νm or less, which fine granules comprise a composition coated by an enteric coating layer, said composition having 10 weight % or more of an acid-labile physiologically active substance and (ii) an additive, has superior disintegrability or dissolution in the oral cavity so that it can be used for treatment or prevention of various diseases, as an orally disintegrable tablet capable of being administered to the aged or children and easily administered without water. Also, because the tablet of the present invention contains fine granules having the average particle diameter such that it will not impart roughness in mouth, it can be administered easily without discomfort at the administration.
PCT/JP1999/002548 1998-05-18 1999-05-17 Orally disintegrable tablets WO1999059544A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
DE69934505T DE69934505T2 (en) 1998-05-18 1999-05-17 IN THE MUND DISSOLVING TABLET CONTAINING A BENZIMIDAZOLE
KR1020047021546A KR101032289B1 (en) 1998-05-18 1999-05-17 Fine granules
DK99919614T DK1121103T3 (en) 1998-05-18 1999-05-17 Orally disintegrable tablets comprising a benzimidazole
AU37316/99A AU3731699A (en) 1998-05-18 1999-05-17 Orally disintegrable tablets
EP99919614A EP1121103B1 (en) 1998-05-18 1999-05-17 Orally disintegrable tablets comprising a benzimidazole
CA002323680A CA2323680C (en) 1998-05-18 1999-05-17 Orally disintegrable tablets
US09/355,781 US6328994B1 (en) 1998-05-18 1999-05-17 Orally disintegrable tablets
HK01106717A HK1036401A1 (en) 1998-05-18 2001-09-22 Orally disintegrable tablets comprising a benzimidazole
US10/017,755 US7431942B2 (en) 1998-05-18 2001-10-30 Orally disintegrable tablets
CY20071100020T CY1105908T1 (en) 1998-05-18 2007-01-08 BENZIMIDAZOLE ORODICALLY DISPERSIBLE TABLETS
US12/151,572 US7875292B2 (en) 1998-05-18 2008-05-07 Orally disintegrable tablets
US12/967,858 US20110081412A1 (en) 1998-05-18 2010-12-14 Orally disintegrable tablets
US14/287,740 US9901546B2 (en) 1998-05-18 2014-05-27 Orally disintegrable tablets

Applications Claiming Priority (10)

Application Number Priority Date Filing Date Title
JP13547298 1998-05-18
JP10/135472 1998-05-18
JP10/219266 1998-08-03
JP21926698 1998-08-03
JP22215198 1998-08-05
JP10/222151 1998-08-05
JP11/5144 1999-01-12
JP514499 1999-01-12
JP1585199 1999-01-25
JP11/15851 1999-01-25

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US09/355,781 A-371-Of-International US6328994B1 (en) 1998-05-18 1999-05-17 Orally disintegrable tablets
US10/017,755 Continuation US7431942B2 (en) 1998-05-18 2001-10-30 Orally disintegrable tablets

Publications (3)

Publication Number Publication Date
WO1999059544A2 WO1999059544A2 (en) 1999-11-25
WO1999059544A3 true WO1999059544A3 (en) 2001-05-03
WO1999059544A9 WO1999059544A9 (en) 2008-02-21

Family

ID=27518561

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP1999/002548 WO1999059544A2 (en) 1998-05-18 1999-05-17 Orally disintegrable tablets

Country Status (16)

Country Link
US (5) US6328994B1 (en)
EP (3) EP2263660B1 (en)
JP (2) JP3746167B2 (en)
KR (2) KR100554924B1 (en)
CN (1) CN1195500C (en)
AT (1) ATE348601T1 (en)
AU (1) AU3731699A (en)
CA (2) CA2587022A1 (en)
CY (2) CY1105908T1 (en)
DE (1) DE69934505T2 (en)
DK (3) DK1736144T3 (en)
ES (2) ES2274625T3 (en)
HK (2) HK1096021A1 (en)
PT (3) PT1736144E (en)
TW (1) TWI243062B (en)
WO (1) WO1999059544A2 (en)

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