WO2002040072A3 - Filler composition for soft tissue augmentation and reconstructive surgery - Google Patents

Filler composition for soft tissue augmentation and reconstructive surgery Download PDF

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Publication number
WO2002040072A3
WO2002040072A3 PCT/CA2001/001622 CA0101622W WO0240072A3 WO 2002040072 A3 WO2002040072 A3 WO 2002040072A3 CA 0101622 W CA0101622 W CA 0101622W WO 0240072 A3 WO0240072 A3 WO 0240072A3
Authority
WO
WIPO (PCT)
Prior art keywords
tissue augmentation
reconstructive surgery
mono
salt
soft tissue
Prior art date
Application number
PCT/CA2001/001622
Other languages
French (fr)
Other versions
WO2002040072A2 (en
Inventor
Eric Andre Desrosiers
Abdellatif Chenite
Cyril Chaput
Matthew Shive
Original Assignee
Biosyntech Canada Inc
Eric Andre Desrosiers
Abdellatif Chenite
Cyril Chaput
Matthew Shive
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Biosyntech Canada Inc, Eric Andre Desrosiers, Abdellatif Chenite, Cyril Chaput, Matthew Shive filed Critical Biosyntech Canada Inc
Priority to CA002429165A priority Critical patent/CA2429165A1/en
Priority to EP01996399A priority patent/EP1333869A2/en
Priority to AU2002220396A priority patent/AU2002220396A1/en
Priority to US10/416,942 priority patent/US20040047892A1/en
Publication of WO2002040072A2 publication Critical patent/WO2002040072A2/en
Publication of WO2002040072A3 publication Critical patent/WO2002040072A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/52—Hydrogels or hydrocolloids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
    • A61K8/73—Polysaccharides
    • A61K8/736—Chitin; Chitosan; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
    • A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
    • A61L24/08—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
    • A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
    • A61L26/0023—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/20—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14—Macromolecular materials
    • A61L27/22—Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/24—Collagen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91—Injection

Abstract

The present invention relates to a filler composition for soft-tissue augmentation and reconstructive surgery comprising an effective amount of an injectable thermo-gelling solution comprising 0.1 to 5.0 % by weight of chitosan or collagen or a derivative thereof; and 1.0 to 20 % by weight of a salt of polyol or sugar selected from the group consisting of mono-phosphate dibasic salt, mono-sulfate salt and a mono-carboxylic acid salt of polyol or sugar. The solution is stable and turns into a gel within a tem-perature range from 20 to 70 °C. The gel has a cosmetically acceptable consistency for providing a mechanical support to surrounding soft tissues once injected therein. The composition can thus be used as filler for soft tissue augmentation and reconstructive surgery.
PCT/CA2001/001622 2000-11-15 2001-11-15 Filler composition for soft tissue augmentation and reconstructive surgery WO2002040072A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002429165A CA2429165A1 (en) 2000-11-15 2001-11-15 Filler composition for soft tissue augmentation and reconstructive surgery
EP01996399A EP1333869A2 (en) 2000-11-15 2001-11-15 Filler composition for soft tissue augmentation
AU2002220396A AU2002220396A1 (en) 2000-11-15 2001-11-15 Filler composition for soft tissue augmentation and reconstructive surgery
US10/416,942 US20040047892A1 (en) 2000-11-15 2001-11-15 Filler composition for soft tissue augmentation and reconstructive surgery

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US24822700P 2000-11-15 2000-11-15
US60/248,227 2000-11-15

Publications (2)

Publication Number Publication Date
WO2002040072A2 WO2002040072A2 (en) 2002-05-23
WO2002040072A3 true WO2002040072A3 (en) 2002-09-19

Family

ID=22938214

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/CA2001/001622 WO2002040072A2 (en) 2000-11-15 2001-11-15 Filler composition for soft tissue augmentation and reconstructive surgery

Country Status (4)

Country Link
EP (1) EP1333869A2 (en)
AU (1) AU2002220396A1 (en)
CA (1) CA2429165A1 (en)
WO (1) WO2002040072A2 (en)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003247816A1 (en) * 2002-07-02 2004-01-23 Procyte Corporation Compositions containing peptide copper complexes and soft tissue fillers
JPWO2005037292A1 (en) * 2003-10-21 2006-12-28 株式会社ネーテック Endoscopic submucosal bulging fluid composition containing a sugar chain-containing chitosan derivative
GB0403938D0 (en) * 2004-02-21 2004-03-24 West Pharm Serv Drug Res Ltd Chitosan containing solution
FR2867073B1 (en) * 2004-03-08 2006-05-05 Europlak COSMETIC USE OF CHITOSAN FOR THE TREATMENT AND COMBULATION OF WRINKLES
FR2897775B1 (en) * 2006-02-24 2013-05-03 Elisabeth Laugier BIOMATERIAU, INJECTABLE IMPLANT COMPRISING IT, PROCESS FOR PREPARING THE SAME AND USES THEREOF
US7776840B2 (en) 2007-02-21 2010-08-17 Cutanea Life Sciences, Inc. Methods of use of biomaterial and injectable implant containing biomaterial
JP5860406B2 (en) * 2010-10-15 2016-02-16 国立大学法人京都大学 Sustained release pharmaceutical composition
WO2014100837A1 (en) * 2012-12-17 2014-06-26 Bui The Duy Computer aided implantation of body implants
US9226797B2 (en) 2012-11-04 2016-01-05 Miba Medical Inc. Computer aided implantation of body implants
KR20150126647A (en) * 2013-03-04 2015-11-12 더멜, 엘엘씨 디/비/에이 에테르노젠, 엘엘씨 Injectable in situ polymerizable collagen composition
US9192574B2 (en) * 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan paste wound dressing
US9192692B2 (en) 2013-10-24 2015-11-24 Medtronic Xomed, Inc. Chitosan stenting paste

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731081A (en) * 1984-09-11 1988-03-15 Mentor Corporation Rupture-resistant prosthesis with creasable shell and method of forming same
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
WO1995025549A1 (en) * 1994-03-23 1995-09-28 Lipomatrix Incorporated Synthetic triglyceride filler material for surgically implanted prostheses
WO1996002276A2 (en) * 1994-07-18 1996-02-01 Gel Sciences, Inc. Novel polymer gel networks and methods of use
US5658593A (en) * 1992-01-16 1997-08-19 Coletica Injectable compositions containing collagen microcapsules
WO1999007416A1 (en) * 1997-08-04 1999-02-18 Bio-Syntech Ltd. TEMPERATURE-CONTROLLED pH-DEPENDANT FORMATION OF IONIC POLYSACCHARIDE GELS
WO2001036000A1 (en) * 1999-11-15 2001-05-25 Bio Syntech Canada, Inc. Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
WO2001041822A1 (en) * 1999-12-09 2001-06-14 Biosyntech Canada Inc. Mineral-polymer hybrid composition

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4731081A (en) * 1984-09-11 1988-03-15 Mentor Corporation Rupture-resistant prosthesis with creasable shell and method of forming same
US4803075A (en) * 1986-06-25 1989-02-07 Collagen Corporation Injectable implant composition having improved intrudability
US5658593A (en) * 1992-01-16 1997-08-19 Coletica Injectable compositions containing collagen microcapsules
WO1995025549A1 (en) * 1994-03-23 1995-09-28 Lipomatrix Incorporated Synthetic triglyceride filler material for surgically implanted prostheses
WO1996002276A2 (en) * 1994-07-18 1996-02-01 Gel Sciences, Inc. Novel polymer gel networks and methods of use
WO1999007416A1 (en) * 1997-08-04 1999-02-18 Bio-Syntech Ltd. TEMPERATURE-CONTROLLED pH-DEPENDANT FORMATION OF IONIC POLYSACCHARIDE GELS
WO2001036000A1 (en) * 1999-11-15 2001-05-25 Bio Syntech Canada, Inc. Temperature-controlled and ph-dependant self-gelling biopolymeric aqueous solution
WO2001041822A1 (en) * 1999-12-09 2001-06-14 Biosyntech Canada Inc. Mineral-polymer hybrid composition

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
CHENITE A ET AL: "Novel injectable neutral solutions of chitosan form biodegradable gels in situ", BIOMATERIALS, ELSEVIER SCIENCE PUBLISHERS BV., BARKING, GB, vol. 21, no. 21, 1 November 2000 (2000-11-01), pages 2155 - 2161, XP004216030, ISSN: 0142-9612 *

Also Published As

Publication number Publication date
CA2429165A1 (en) 2002-05-23
EP1333869A2 (en) 2003-08-13
WO2002040072A2 (en) 2002-05-23
AU2002220396A1 (en) 2002-05-27

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