WO2004016248A8 - Forme galenique pour la delivrance colique de principes actifs - Google Patents

Forme galenique pour la delivrance colique de principes actifs

Info

Publication number
WO2004016248A8
WO2004016248A8 PCT/FR2003/002474 FR0302474W WO2004016248A8 WO 2004016248 A8 WO2004016248 A8 WO 2004016248A8 FR 0302474 W FR0302474 W FR 0302474W WO 2004016248 A8 WO2004016248 A8 WO 2004016248A8
Authority
WO
WIPO (PCT)
Prior art keywords
targeted delivery
active principles
colon targeted
galenic formulation
colon
Prior art date
Application number
PCT/FR2003/002474
Other languages
English (en)
Other versions
WO2004016248A3 (fr
WO2004016248A2 (fr
Inventor
Sandrine Bourgeois
Elias Fattal
Antoine Andremont
Patrick Couvreur
Original Assignee
Centre Nat Rech Scient
Da Volterra
Sandrine Bourgeois
Elias Fattal
Antoine Andremont
Patrick Couvreur
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR0210151A external-priority patent/FR2843301B1/fr
Priority to AU2003274229A priority Critical patent/AU2003274229B2/en
Priority to DE60327772T priority patent/DE60327772D1/de
Priority to JP2004528586A priority patent/JP2006500359A/ja
Priority to EP03758212A priority patent/EP1526841B1/fr
Priority to CA002495291A priority patent/CA2495291A1/fr
Priority to US10/524,318 priority patent/US7485294B2/en
Priority to BR0313469-5A priority patent/BR0313469A/pt
Application filed by Centre Nat Rech Scient, Da Volterra, Sandrine Bourgeois, Elias Fattal, Antoine Andremont, Patrick Couvreur filed Critical Centre Nat Rech Scient
Priority to MXPA05001607A priority patent/MXPA05001607A/es
Priority to CN038213656A priority patent/CN1681480B/zh
Priority to AT03758212T priority patent/ATE432066T1/de
Publication of WO2004016248A2 publication Critical patent/WO2004016248A2/fr
Publication of WO2004016248A3 publication Critical patent/WO2004016248A3/fr
Publication of WO2004016248A8 publication Critical patent/WO2004016248A8/fr
Priority to US12/345,647 priority patent/US7833765B2/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/48Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005Wall or coating material
    • A61K9/5021Organic macromolecular compounds
    • A61K9/5036Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/43Enzymes; Proenzymes; Derivatives thereof
    • A61K38/46Hydrolases (3)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605Excipients; Inactive ingredients
    • A61K9/1629Organic macromolecular compounds
    • A61K9/1652Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10Laxatives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents

Abstract

Formes galéniques multiparticulaires aptes à être utilisées par voie orale et destinées à la délivrance colique de principes actifs choisis dans le groupe comprenant les enzymes capables d'inactiver les macrolides et apparentés, les enzymes capables d'inactiver les quinolones et les β-lactamases.
PCT/FR2003/002474 2002-08-09 2003-08-06 Forme galenique pour la delivrance colique de principes actifs WO2004016248A2 (fr)

Priority Applications (11)

Application Number Priority Date Filing Date Title
AT03758212T ATE432066T1 (de) 2002-08-09 2003-08-06 Arzneimittel für die dickdarmverabreichung von wirkstoffen
BR0313469-5A BR0313469A (pt) 2002-08-09 2003-08-06 Forma galêmica para a liberação cólica de princìpios ativos
JP2004528586A JP2006500359A (ja) 2002-08-09 2003-08-06 有効成分の結腸標的指向送達用ガレヌス製剤形態
EP03758212A EP1526841B1 (fr) 2002-08-09 2003-08-06 Forme galenique pour la delivrance colique de principes actifs
CA002495291A CA2495291A1 (fr) 2002-08-09 2003-08-06 Forme galenique pour la delivrance colique de principes actifs
US10/524,318 US7485294B2 (en) 2002-08-09 2003-08-06 Galenic pectinate formulation for colon-targeted delivery of antibiotic-inactivating enzymes and method of use thereof
MXPA05001607A MXPA05001607A (es) 2002-08-09 2003-08-06 Forma galenica para suministro de ingredientes activos dirigido al colon.
AU2003274229A AU2003274229B2 (en) 2002-08-09 2003-08-06 Galenic formulation for colon targeted delivery of active ingredients
DE60327772T DE60327772D1 (de) 2002-08-09 2003-08-06 Arzneimittel für die dickdarmverabreichung von wirkstoffen
CN038213656A CN1681480B (zh) 2002-08-09 2003-08-06 用于活性成分结肠靶向释放的盖仑制剂
US12/345,647 US7833765B2 (en) 2002-08-09 2008-12-29 Galenic formulation for colon-targeted delivery of active ingredients

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR02/10151 2002-08-09
FR0210151A FR2843301B1 (fr) 2002-08-09 2002-08-09 Forme galenique pour la delivrance colique de principes actifs
FR0213514A FR2843302B1 (fr) 2002-08-09 2002-10-29 Forme galenique pour la delivrance colique de principes actifs
FR02/13514 2002-10-29

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US10/524,318 A-371-Of-International US7485294B2 (en) 2002-08-09 2003-08-06 Galenic pectinate formulation for colon-targeted delivery of antibiotic-inactivating enzymes and method of use thereof
US12/345,647 Continuation US7833765B2 (en) 2002-08-09 2008-12-29 Galenic formulation for colon-targeted delivery of active ingredients

Publications (3)

Publication Number Publication Date
WO2004016248A2 WO2004016248A2 (fr) 2004-02-26
WO2004016248A3 WO2004016248A3 (fr) 2004-04-08
WO2004016248A8 true WO2004016248A8 (fr) 2004-05-21

Family

ID=30772009

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/FR2003/002474 WO2004016248A2 (fr) 2002-08-09 2003-08-06 Forme galenique pour la delivrance colique de principes actifs

Country Status (14)

Country Link
US (2) US7485294B2 (fr)
EP (2) EP1992336A3 (fr)
JP (1) JP2006500359A (fr)
KR (1) KR101080577B1 (fr)
CN (1) CN1681480B (fr)
AT (1) ATE432066T1 (fr)
AU (1) AU2003274229B2 (fr)
BR (1) BR0313469A (fr)
CA (1) CA2495291A1 (fr)
DE (1) DE60327772D1 (fr)
ES (1) ES2327630T3 (fr)
FR (1) FR2843302B1 (fr)
MX (1) MXPA05001607A (fr)
WO (1) WO2004016248A2 (fr)

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JP4694145B2 (ja) * 2004-05-17 2011-06-08 株式会社 メドレックス 経口腸溶性製剤
JP2008529996A (ja) * 2005-02-09 2008-08-07 ダ・ボルテラ 活性因子の大腸送達
WO2006122835A1 (fr) * 2005-05-18 2006-11-23 Da Volterra Administration colonique d'adsorbants
JP4962888B2 (ja) * 2005-06-03 2012-06-27 株式会社 メドレックス 経口腸溶性医薬組成物
US8048413B2 (en) * 2006-05-17 2011-11-01 Helene Huguet Site-specific intestinal delivery of adsorbents, alone or in combination with degrading molecules
FI119190B (fi) 2006-06-21 2008-08-29 Ipsat Therapies Oy Modifioitu beta-laktamaasi ja menetelmä sen valmistamiseksi
US8273376B2 (en) 2006-11-17 2012-09-25 Da Volterra Colonic delivery of metallo-dependent enzymes
US20080124279A1 (en) * 2006-11-17 2008-05-29 Antoine Andremont Colonic delivery using Zn/pectin beads with a Eudragit coating
FI119678B (fi) * 2006-11-28 2009-02-13 Ipsat Therapies Oy Beta-laktamaasin käyttö
GB0713116D0 (en) * 2007-07-06 2007-08-15 Therapeutics Ltd E Treatment of melanoma
GB0714226D0 (en) * 2007-07-20 2007-08-29 Therapeutics Ltd E anti-bacterial combination therapy
US20100239682A1 (en) * 2007-09-17 2010-09-23 Antoine Andremont Colonic delivery of antimicrobial agents
GB0719771D0 (en) * 2007-10-10 2007-11-21 Therapeutics Ltd E Dexanabinol in combination with inhibitors of BRAF or MEK for the treatment of melanoma
GB0813211D0 (en) 2008-07-18 2008-08-27 E Therapeutics Plc Antibacterial combination therapy for the treatment of gram positive bacterial infections
FR2950252B1 (fr) * 2009-09-23 2012-01-20 Centre Nat Rech Scient Forme galenique capable d'adsorber de maniere specifique les molecules indesirables
EP2538930B1 (fr) 2010-02-23 2016-06-15 Da Volterra Formulation pour l'administration orale d'adsorbants dans l'intestin
FI20105572A0 (fi) 2010-05-24 2010-05-24 Prevab R Lcc Muokattu beeta-laktamaasi ja siihen liittyvät menetelmät ja käytöt
AU2015247382B2 (en) 2014-04-17 2020-04-23 Theriva Biologics, Inc. Beta-lactamases with improved properties for therapy
WO2016033327A1 (fr) 2014-08-28 2016-03-03 Synthetic Biologics, Inc. Production de bêta-lactamase à partir d'e-coli
EP3204495B1 (fr) 2014-10-08 2020-04-22 Synthetic Biologics, Inc. Formulations de bêta-lactamase et utilisations de celles-ci
FR3027307B1 (fr) 2014-10-16 2016-11-04 Azurrx Sas Molecule proteique hybride apte a inhiber au moins un antibiotique et composition pharmaceutique la comportant
EP3236993B1 (fr) 2014-12-23 2023-09-13 Theriva Biologics, Inc. Méthodes et compositions pour inhiber ou prévenir les effets néfastes des antibiotiques oraux
JP6810697B2 (ja) 2015-02-23 2021-01-13 シンセティック・バイオロジクス・インコーポレイテッド 腸内マイクロバイオームの保護のために抗生物質と共に使用するカルバペネマーゼ
EP3265119B1 (fr) 2015-03-06 2023-10-11 Theriva Biologics, Inc. Dosage de beta-lactamase sûr et efficace pour la protection du microbiome
US10182993B2 (en) 2015-04-06 2019-01-22 Patheon Softgels Inc. Compositions for colonic delivery of drugs
US10988749B2 (en) 2016-02-23 2021-04-27 Da Volterra Beta-lactamase variants
EP3420078B1 (fr) 2016-02-23 2022-05-25 Da Volterra Variants de beta-lactamase
BR112020000196A2 (pt) 2017-07-07 2020-07-07 Epicentrx, Inc. composições para administração parenteral de agentes terapêuticos
BR112020007974A2 (pt) 2017-10-25 2020-10-27 Da Volterra variantes de beta- lactamase

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Also Published As

Publication number Publication date
CN1681480A (zh) 2005-10-12
EP1992336A2 (fr) 2008-11-19
KR20050083628A (ko) 2005-08-26
EP1526841A2 (fr) 2005-05-04
WO2004016248A3 (fr) 2004-04-08
AU2003274229B2 (en) 2009-05-21
US7833765B2 (en) 2010-11-16
EP1992336A3 (fr) 2009-05-13
ES2327630T3 (es) 2009-11-02
WO2004016248A2 (fr) 2004-02-26
ATE432066T1 (de) 2009-06-15
FR2843302B1 (fr) 2004-10-22
US20090162339A1 (en) 2009-06-25
CA2495291A1 (fr) 2004-02-26
US20050249716A1 (en) 2005-11-10
KR101080577B1 (ko) 2011-11-04
US7485294B2 (en) 2009-02-03
CN1681480B (zh) 2010-04-14
FR2843302A1 (fr) 2004-02-13
DE60327772D1 (de) 2009-07-09
EP1526841B1 (fr) 2009-05-27
AU2003274229A1 (en) 2004-03-03
BR0313469A (pt) 2005-07-12
JP2006500359A (ja) 2006-01-05
MXPA05001607A (es) 2005-09-20

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