WO2005023176A3 - Delivery of physiologixal agents with in-situ gels comprising anionic polysaccharides - Google Patents

Delivery of physiologixal agents with in-situ gels comprising anionic polysaccharides Download PDF

Info

Publication number
WO2005023176A3
WO2005023176A3 PCT/US2004/016146 US2004016146W WO2005023176A3 WO 2005023176 A3 WO2005023176 A3 WO 2005023176A3 US 2004016146 W US2004016146 W US 2004016146W WO 2005023176 A3 WO2005023176 A3 WO 2005023176A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
agents
anionic polysaccharides
physiologixal
tissues
Prior art date
Application number
PCT/US2004/016146
Other languages
French (fr)
Other versions
WO2005023176A2 (en
Inventor
Yawei Ni
Kenneth M Yates
Original Assignee
Delsite Biotechnologies Inc
Yawei Ni
Kenneth M Yates
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Delsite Biotechnologies Inc, Yawei Ni, Kenneth M Yates filed Critical Delsite Biotechnologies Inc
Priority to CA2537290A priority Critical patent/CA2537290C/en
Priority to AU2004270101A priority patent/AU2004270101A1/en
Priority to JP2006524618A priority patent/JP4765020B2/en
Priority to EA200600484A priority patent/EA010351B1/en
Priority to EP04753044A priority patent/EP1663111A4/en
Publication of WO2005023176A2 publication Critical patent/WO2005023176A2/en
Publication of WO2005023176A3 publication Critical patent/WO2005023176A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1825—Fibroblast growth factor [FGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/05—Actinobacteria, e.g. Actinomyces, Streptomyces, Nocardia, Bifidobacterium, Gardnerella, Corynebacterium; Propionibacterium
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/12—Viral antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5252—Virus inactivated (killed)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A61K2039/541—Mucosal route
    • A61K2039/543—Mucosal route intranasal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55583—Polysaccharides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B82—NANOTECHNOLOGY
    • B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
    • C12N2760/00011—Details
    • C12N2760/16011—Orthomyxoviridae
    • C12N2760/16111—Influenzavirus A, i.e. influenza A virus
    • C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein

Abstract

In-situ gelling compositions for delivering pharmacologically active substances to the tissues, body fluids, and mucosal surfaces of animal patients in the form of liquids, solids and powders, comprising anionic polysaccharides and especially low methoxyl pectins as gelling agents, methods of preparation, and method of use of the in-situ gelling compositions for the delivery and sustained release of a physiologically active agent, and especially vaccine antigens, to the tissues and mucosal surfaces of an animal.
PCT/US2004/016146 2003-08-29 2004-05-24 Delivery of physiologixal agents with in-situ gels comprising anionic polysaccharides WO2005023176A2 (en)

Priority Applications (5)

Application Number Priority Date Filing Date Title
CA2537290A CA2537290C (en) 2003-08-29 2004-05-24 Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
AU2004270101A AU2004270101A1 (en) 2003-08-29 2004-05-24 Delivery of physiologixal agents with in-situ gels comprising anionic polysaccharides
JP2006524618A JP4765020B2 (en) 2003-08-29 2004-05-24 Physiological drug delivery in situ gels containing anionic polysaccharides
EA200600484A EA010351B1 (en) 2003-08-29 2004-05-24 Delivery of physiological agents withgels comprising anionic polysaccharides
EP04753044A EP1663111A4 (en) 2003-08-29 2004-05-24 Delivery of physiologixal agents with in-situ gels comprising anionic polysaccharides

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/652,622 US7494669B2 (en) 2001-02-28 2003-08-29 Delivery of physiological agents with in-situ gels comprising anionic polysaccharides
US10/652,622 2003-08-29

Publications (2)

Publication Number Publication Date
WO2005023176A2 WO2005023176A2 (en) 2005-03-17
WO2005023176A3 true WO2005023176A3 (en) 2006-06-15

Family

ID=34273408

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2004/016146 WO2005023176A2 (en) 2003-08-29 2004-05-24 Delivery of physiologixal agents with in-situ gels comprising anionic polysaccharides

Country Status (9)

Country Link
US (1) US7494669B2 (en)
EP (1) EP1663111A4 (en)
JP (1) JP4765020B2 (en)
KR (1) KR20060127841A (en)
CN (1) CN1874679A (en)
AU (1) AU2004270101A1 (en)
CA (1) CA2537290C (en)
EA (1) EA010351B1 (en)
WO (1) WO2005023176A2 (en)

Families Citing this family (50)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7022683B1 (en) * 1998-05-13 2006-04-04 Carrington Laboratories, Inc. Pharmacological compositions comprising pectins having high molecular weights and low degrees of methoxylation
US20050113730A1 (en) * 2003-11-24 2005-05-26 Sca Hygiene Products Ab Absorbent Article Containing A Skin Care Product
AR048709A1 (en) * 2004-04-26 2006-05-17 Cp Kelco Aps DERMOPROTECTOR COMPOSITION TO CONTROL THE ALKALINITY AND USE OF IT
US20060106117A1 (en) * 2004-11-12 2006-05-18 Kimberly-Clark Worldwide, Inc. Compound and method for prevention and/or treatment of vaginal infections
US20060223765A1 (en) * 2005-03-30 2006-10-05 Kimberly-Clark Worldwide, Inc. Method for inhibiting and/or treating vaginal infection
US7786176B2 (en) 2005-07-29 2010-08-31 Kimberly-Clark Worldwide, Inc. Vaginal treatment composition containing xylitol
CA2633655A1 (en) * 2005-12-19 2007-07-05 Comentis, Inc. Topical mecamylamine formulations for ocular administration and uses therof
KR20100014509A (en) * 2007-03-13 2010-02-10 바이오라인알엑스 리미티드 A method of promoting tissue repair
CN101720226B (en) * 2007-05-11 2013-01-30 芦荟研究实验室公司 Aloe preparation for skin enhancement
PT2268142T (en) 2007-11-27 2017-06-02 Algipharma As Use of alginated oligomers in combating biofilms
JP2009209086A (en) * 2008-03-04 2009-09-17 Masami Moriyama Mucous membrane administration-type vaccine
US7833829B2 (en) * 2008-10-28 2010-11-16 Honeywell International Inc. MEMS devices and methods of assembling micro electromechanical systems (MEMS)
GB0909557D0 (en) 2009-06-03 2009-07-15 Algipharma Ipr As Anti-microbial alginate oligomers
GB0909529D0 (en) 2009-06-03 2009-07-15 Algipharma Ipr As Alginate oligomers for the inhibition of microbial adherence to surfaces
ES2444541T3 (en) 2009-06-03 2014-02-25 Algipharma As Alginate oligomers to use to overcome drug multiresistance in bacteria
JP2011057605A (en) * 2009-09-09 2011-03-24 Masami Moriyama Vaccine to be applied to mucous membrane
CN101703490B (en) * 2009-11-13 2013-08-07 杭州师范大学 Polysaccharide/inorganic nanoparticles hybrid micron-nano medicine-carrying capsule
US8852645B2 (en) 2009-11-19 2014-10-07 The Board Of Trustees Of The University Of Illinois Self-assembled toroidal-spiral particles and manufacture and uses thereof
US9439958B2 (en) * 2009-12-23 2016-09-13 Arizona Board Of Regents Acting For And On Behalf Of Arizona State University Stabilized virus like particles having enhanced mucosal immunogenicity
JP5996837B2 (en) * 2010-05-28 2016-09-21 小林製薬株式会社 Influenza virus infection inhibitor
FR2960775A1 (en) * 2010-06-07 2011-12-09 Ethypharm Sa MICROGRANULES RESISTANT TO MISMATCH
ITVR20100140A1 (en) * 2010-07-13 2012-01-14 Eurocoating S P A COMPOSITE MATERIAL FORMED BY PECTIN AND CALCIUM PHOSPHATE AND METHOD FOR ITS REALIZATION
SG10201507554RA (en) 2010-09-13 2015-10-29 Bev Rx Inc Aqueous drug delivery system comprising off - flavor masking agent
CA2833369C (en) * 2011-04-18 2020-09-08 Donald A. Harn Vaccine delivery method
GB2490516A (en) 2011-05-03 2012-11-07 Systagenix Wound Man Ip Co Bv Polysaccharide mould for wound treatment
GB201116010D0 (en) 2011-09-15 2011-10-26 Algipharma As Use of alginate oligomers to enhance the effects of antifungal agents
EP2782603A1 (en) 2011-11-25 2014-10-01 Danmarks Tekniske Universitet Formulation of solid nano-sized particles in a gel-forming system
CN102429862B (en) * 2011-11-29 2013-05-01 江苏德达医药科技有限公司 Sustained-release povidone iodine eye drops
GB201322777D0 (en) 2013-12-20 2014-02-05 Algipharma As Use of alginate oligomers as blood anticoagulants
US20160158174A1 (en) * 2014-12-09 2016-06-09 Intercontinental Great Brands Llc Enteric-Coated Functional Food Ingredients And Methods For Making The Enteric-Coated Functional Food Ingredients
EP3034070A1 (en) * 2014-12-18 2016-06-22 Omya International AG Method for the production of a pharmaceutical delivery system
US20180008646A1 (en) * 2015-01-30 2018-01-11 Nissan Chemical Industries, Ltd. Method for cultivating vascular smooth muscle cells
KR101777910B1 (en) * 2015-04-30 2017-09-13 주식회사 제네웰 A composition for wound healing, method of producing the same and dressing using the same
US11045578B2 (en) 2015-06-24 2021-06-29 Biovotec As Tissue engineering scaffolds comprising particulate egg shell membrane
US20180243397A1 (en) 2015-08-28 2018-08-30 Ron Cobb Norovirus vaccine
GB201517639D0 (en) 2015-10-06 2015-11-18 Algipharma As Use of alginate oligomers to treat or prevent microbial overgrowth in the intestinal tract
GB201519923D0 (en) 2015-11-11 2015-12-23 Biovotec Dac And Biovotec As Dry biocompatible disintegrateable films for delivering particulate egg shell membrane to a wound
WO2017151651A1 (en) * 2016-02-29 2017-09-08 Belmont University Pharmaceutical in situ gelling compositions
GB201618291D0 (en) 2016-10-28 2016-12-14 Bergen Teknologioverf�Ring As Novel immunotherapeutic treatments for tumours
US10912858B2 (en) * 2017-05-01 2021-02-09 The Brigham And Women's Hospital, Inc. Pectin-carboxymethylcellulose mesothelial sealants and protectants
EP3651588B1 (en) 2017-07-11 2024-03-13 Givaudan SA Method for preparing a colour-stable preparation of a magnesium chlorophyllin alkali metal salt or alkali earth metal salt from natural sources of chlorophyll
EP3694491A1 (en) 2017-10-10 2020-08-19 Capsugel Belgium NV Gelling multiparticulates
WO2019092608A1 (en) 2017-11-08 2019-05-16 Materias S.R.L. In situ gelifying powder
EP3556398A1 (en) 2018-04-16 2019-10-23 Croda Denmark A/S Phytates for use as a biomolecules delivery or adsorption system
GB201908639D0 (en) 2019-06-17 2019-07-31 Algipharma Ipr As Use of alginate oligomers in the anticoagulation therapy of subjects at risk of blood clots which have an abnormally dense microstructure
US11793230B2 (en) 2019-12-09 2023-10-24 Nicoventures Trading Limited Oral products with improved binding of active ingredients
US11872231B2 (en) 2019-12-09 2024-01-16 Nicoventures Trading Limited Moist oral product comprising an active ingredient
US11826462B2 (en) 2019-12-09 2023-11-28 Nicoventures Trading Limited Oral product with sustained flavor release
CN114146169B (en) * 2021-12-28 2023-08-25 佛山市正典生物技术有限公司 Carrier composition for chicken coccidium spray-drop immunization, using method and chicken coccidium spray-drop immunization composition
WO2024004159A1 (en) * 2022-06-30 2024-01-04 Ｅｐｓ創薬株式会社 Vaccine composition for sublingual administration

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978528A (en) * 1986-06-23 1990-12-18 Bio Serae Laboratoires S.A. Process for preventing degradation of an anti-bacterial composition

Family Cites Families (157)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2629665A (en) * 1951-10-31 1953-02-24 James B Gordon Dietetic food product and method of preparing the same
US3622559A (en) 1967-11-01 1971-11-23 Sunkist Growers Inc Method for producing pectins having high resistance to breakage and high capability for gelling in the presence of calcium
US3946110A (en) * 1974-05-30 1976-03-23 Peter, Strong Research And Development Company, Inc. Medicinal compositions and methods of preparing the same
US3982003A (en) 1974-09-04 1976-09-21 Mars Limited Gelling and thickening agents
US4016351A (en) 1976-02-04 1977-04-05 Eschinasi Emile H Pectic substances with varying methoxyl content and process therefor
HU179474B (en) 1978-02-24 1982-10-28 Laszlo Gyarmati Process for preparing solid oral pharmaceutical compositons with increased length of activity and with a regulated release of the active material
US4305933A (en) 1980-03-10 1981-12-15 Wiczer Sol B Thickened gelatinous edible alcoholic medicated carrier
JPS607965B2 (en) * 1980-08-07 1985-02-28 帝人株式会社 Method for manufacturing powder for nasal mucosal administration
US4497838A (en) 1982-02-17 1985-02-05 Tropicana Products, Inc. Process for the production of useful products from orange peel
US4735935A (en) 1985-12-17 1988-04-05 Carrington Laboratories, Inc. Process for preparation of aloe products products, produced thereby and compositions thereof
US4966892A (en) 1982-05-07 1990-10-30 Carrington Laboratories, Inc. Processes for preparation of aloe products products produced thereby and compositions thereof
US5106616A (en) 1988-01-14 1992-04-21 Carrington Laboratories, Inc. Administration of acemannan
US5308838A (en) 1982-05-07 1994-05-03 Carrington Laboratories, Inc. Uses of aloe products
US5118673A (en) 1982-05-07 1992-06-02 Carrington Laboratories, Inc. Uses of aloe products
US4917890A (en) 1985-06-28 1990-04-17 Carrington Laboratories, Inc. Processes for preparation of aloe products, products produced thereby and compositions thereof
US4851224A (en) 1986-06-05 1989-07-25 Carrington Laboratories, Inc. Process for preparation of aloe products
US5443830A (en) 1982-05-07 1995-08-22 Carrington Laboratories, Inc. Drink containing mucilaginous polysaccharides and its preparation
US5656587A (en) 1982-09-24 1997-08-12 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Promotion of cell proliferation by use of transforming growth factor beta (TGF-β)
US4500510A (en) 1982-09-29 1985-02-19 Aquarium Pharmaceuticals, Inc. Damaged fish tissue treating method and composition containing Aloe vera extract
JPS59163313A (en) 1983-03-09 1984-09-14 Teijin Ltd Peptide hormone composition for nasal administration
JPS60100516A (en) 1983-11-04 1985-06-04 Takeda Chem Ind Ltd Preparation of sustained release microcapsule
US5288498A (en) 1985-05-01 1994-02-22 University Of Utah Research Foundation Compositions of oral nondissolvable matrixes for transmucosal administration of medicaments
DE3583799D1 (en) 1985-01-11 1991-09-19 Abbott Lab Ltd SOLID PREPARATION WITH SLOW RELEASE.
US4957907A (en) 1985-06-28 1990-09-18 Carrington Laboratories Inc. Process for preparation of aloe products
US4959214A (en) 1985-06-28 1990-09-25 Carrington Laboratories Inc. Processes for preparation of aloe products products produced thereby and compositions thereof
EP0248051A1 (en) 1985-11-29 1987-12-09 FISONS plc Pharmaceutical composition including sodium cromoglycate
DE3601132A1 (en) 1986-01-16 1987-07-23 Christian Bannert METHOD FOR TREATING THE MUCUS
DE3601923A1 (en) 1986-01-23 1987-07-30 Behringwerke Ag NASAL APPLICABLE MEDICINE, METHOD FOR THE PRODUCTION AND USE THEREOF
US5552528A (en) 1986-03-03 1996-09-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Bovine b-endothelial cell growth factor
US4725438A (en) 1986-05-29 1988-02-16 Leazer Billie S Aloe vera ointment
US5288500A (en) 1987-03-13 1994-02-22 Benzon Pharma A/S Oral composition containing particles comprising an active substance
FR2613936B1 (en) 1987-04-17 1990-03-30 Centre Nat Rech Scient APPLICATION OF RESINS CONSTITUTED BY FUNCTIONAL POLYMERS AS A STATIONARY PHASE IN AFFINITY CHROMATOGRAPHY FOR THE PURIFICATION OF GROWTH FACTORS AND CORRESPONDING PURIFICATION METHOD
US5690954A (en) 1987-05-22 1997-11-25 Danbiosyst Uk Limited Enhanced uptake drug delivery system having microspheres containing an active drug and a bioavailability improving material
DE3726797A1 (en) 1987-08-12 1989-02-23 Bayer Ag MEDICINAL PRODUCTS FOR ORAL CAVES
US5059189A (en) 1987-09-08 1991-10-22 E. R. Squibb & Sons, Inc. Method of preparing adhesive dressings containing a pharmaceutically active ingredient
EP0308181A1 (en) * 1987-09-14 1989-03-22 Novo Nordisk A/S Trans-mucosal delivery formulations and a method for preparation thereof
GB8723846D0 (en) 1987-10-10 1987-11-11 Danbiosyst Ltd Bioadhesive microsphere drug delivery system
DE3886880T2 (en) * 1987-10-15 1994-07-14 Syntex Inc Powdery preparations for intranasal administration of polypeptides.
US5246708A (en) 1987-10-28 1993-09-21 Pro-Neuron, Inc. Methods for promoting wound healing with deoxyribonucleosides
US5064650A (en) 1988-04-19 1991-11-12 Southwest Research Institute Controlled-release salt sensitive capsule for oral use and adhesive system
US5438076A (en) 1988-05-03 1995-08-01 Perio Products, Ltd. Liquid polymer composition, and method of use
US4925677A (en) 1988-08-31 1990-05-15 Theratech, Inc. Biodegradable hydrogel matrices for the controlled release of pharmacologically active agents
GB8826116D0 (en) * 1988-11-08 1988-12-14 Danbiosyst Ltd Adhesive drug delivery composition
GEP20022681B (en) 1989-01-31 2002-04-25 Aaronson Us Stuart A Protein KFG, Antibodies, Pharmaceutical Composition, Their Use, recombinant DNA, Cell, Method for Discoveries and Production of Proteins, Method for Stimulation of Epithelial Cells Growth
US5356630A (en) 1989-02-22 1994-10-18 Massachusetts Institute Of Technology Delivery system for controlled release of bioactive factors
US5576288A (en) 1989-04-27 1996-11-19 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US5191067A (en) 1989-04-27 1993-03-02 The Salk Institute For Biological Studies Fibroblast growth factor conjugates
US5130418A (en) 1989-05-02 1992-07-14 California Biotechnology Inc. Method to stabilize basic fibroblast growth factor
US5599551A (en) 1989-06-06 1997-02-04 Kelly; Patrick D. Genital lubricants containing zinc as an anti-viral agent
US5545673A (en) 1989-06-06 1996-08-13 Kelly; Patrick D. Method for reducing risk of infection by sexually transmitted viruses
US5208031A (en) 1989-06-06 1993-05-04 Kelly Patrick D Sexual lubricants containing zinc as an anti-viral agent
US5079018A (en) 1989-08-14 1992-01-07 Neophore Technologies, Inc. Freeze dry composition and method for oral administration of drugs, biologicals, nutrients and foodstuffs
US5158934A (en) 1989-09-01 1992-10-27 Genentech, Inc. Method of inducing bone growth using TGF-β
US5422340A (en) 1989-09-01 1995-06-06 Ammann; Arthur J. TGF-βformulation for inducing bone growth
JP2911496B2 (en) 1989-09-11 1999-06-23 帝國製薬株式会社 Highly absorbable vaginal agent containing bioactive polypeptide
US5707644A (en) 1989-11-04 1998-01-13 Danbiosyst Uk Limited Small particle compositions for intranasal drug delivery
GB2237510B (en) * 1989-11-04 1993-09-15 Danbiosyst Uk Small particle drug compositions for nasal administration
US5512306A (en) 1992-06-19 1996-04-30 Pharmica Ab Smoking substitute
US5188825A (en) 1989-12-28 1993-02-23 Iles Martin C Freeze-dried dosage forms and methods for preparing the same
US5284659A (en) 1990-03-30 1994-02-08 Cherukuri Subraman R Encapsulated flavor with bioadhesive character in pressed mints and confections
US5217954A (en) 1990-04-04 1993-06-08 Scios Nova Inc. Formulations for stabilizing fibroblast growth factor
IL98087A (en) 1990-05-04 1996-11-14 Perio Prod Ltd Colonic drug delivery system
US5612211A (en) 1990-06-08 1997-03-18 New York University Stimulation, production and culturing of hematopoietic progenitor cells by fibroblast growth factors
SE9002339L (en) 1990-07-04 1992-01-05 Kabi Pharmacia Ab THERAPEUTIC COMPOSITION AND PROCEDURE FOR ITS PREPARATION
US5714458A (en) 1990-07-18 1998-02-03 Farmitalia Carlo Erba S.R.L. Stable pharmaceutical compositions containing a fibroblast growth factor
US5071644A (en) 1990-08-07 1991-12-10 Mediventures, Inc. Topical drug delivery with thermo-irreversible gels
KR930006431B1 (en) 1990-10-11 1993-07-16 재단법인 한국화학연구소 Microcapsulation of drugs
DK0486862T3 (en) 1990-11-23 1996-06-24 American Cyanamid Co Chimeric fibrolast growth factor
US5215758A (en) 1991-09-11 1993-06-01 Euroceltique, S.A. Controlled release matrix suppository for pharmaceuticals
US5192802A (en) 1991-09-25 1993-03-09 Mcneil-Ppc, Inc. Bioadhesive pharmaceutical carrier
US5318780A (en) 1991-10-30 1994-06-07 Mediventures Inc. Medical uses of in situ formed gels
ATE140594T1 (en) 1991-11-14 1996-08-15 Gist Brocades Nv METHOD FOR PRODUCING JUICES FROM FRUITS AND VEGETABLES
US6033712A (en) * 1994-05-13 2000-03-07 Ei Du Pont De Nemours And Company Gel production from plant matter
US5266318A (en) 1991-12-09 1993-11-30 Royale Renaissance, Inc. Skin therapeutic mixture containing cold-processsed aloe vera extract, with yellow sap and aloin removed
EP0661966B1 (en) 1991-12-17 2000-07-19 Biovail Technologies Ltd. Ulcer prevention and treatment composition and method
DE4201172C1 (en) 1992-01-17 1993-07-22 Alfatec-Pharma Gmbh, 6900 Heidelberg, De Pellets contg. Aloe vera extract - useful, e.g. as antiinflammatory of antibiotic agents, or for treating gastric ulcers
US5578307A (en) 1992-01-17 1996-11-26 Alfatec-Pharma Gmbh Shaped articles containing plant extract(s), in particular pellets, and their pharmaceutical or cosmetic use
CA2108277A1 (en) 1992-02-14 1993-08-15 Mitsuru Watanuki Preparation for the therapy of respiratory tract diseases
US6197346B1 (en) * 1992-04-24 2001-03-06 Brown Universtiy Research Foundation Bioadhesive microspheres and their use as drug delivery and imaging systems
US6582728B1 (en) * 1992-07-08 2003-06-24 Inhale Therapeutic Systems, Inc. Spray drying of macromolecules to produce inhaleable dry powders
US5589451A (en) 1992-09-21 1996-12-31 Board Of Regents, The University Of Texas System Methods and treaments for corneal healing with hepatocyte and keratinocyte growth factors
US5703047A (en) 1992-09-21 1997-12-30 Board Of Regents, The University Of Texas System Methods and treatments for corneal healing with growth factors
US5645827A (en) 1992-09-30 1997-07-08 Union Carbide Chemicals & Plastics Technology Corporation Muco-adhesive polymers
JP3266674B2 (en) * 1992-11-19 2002-03-18 クミアイ化学工業株式会社 Plant growth regulator composition
GB9310412D0 (en) * 1993-05-20 1993-07-07 Danbiosyst Uk Nasal nicotine system
US5409703A (en) 1993-06-24 1995-04-25 Carrington Laboratories, Inc. Dried hydrogel from hydrophilic-hygroscopic polymer
US5453492A (en) 1993-07-28 1995-09-26 La Jolla Cancer Research Foundation 60 kDa transforming growth factor-β-binding protein and its use to detect or purify TGF-β
US5464815A (en) 1993-09-08 1995-11-07 Genentech, Inc. Inhibition of heparin-binding
US5435997A (en) 1994-02-08 1995-07-25 Burns; Michael J. Topical agent and method for the treatment of pseudofolliculitis barbae
DK0881908T3 (en) 1994-03-08 2004-10-25 Osteosa Inc Use of fiber blast growth factors to stimulate bone growth
US5656598A (en) 1994-03-08 1997-08-12 Rhone-Poulenc Rorer Pharmaceuticals Inc. Use of fibroblast growth factors to stimulate bone growth
US5503822A (en) 1994-04-01 1996-04-02 Schulman; Jerome M. Medicated gel
US5571531A (en) 1994-05-18 1996-11-05 Mcmaster University Microparticle delivery system with a functionalized silicone bonded to the matrix
GB9412394D0 (en) * 1994-06-21 1994-08-10 Danbiosyst Uk Colonic drug delivery composition
US5849327A (en) 1994-07-29 1998-12-15 Advanced Polymer Systems, Inc. Delivery of drugs to the lower gastrointestinal tract
JPH08198772A (en) * 1994-11-25 1996-08-06 Kirin Brewery Co Ltd Powdery transnasal preparation containing granulocyte colony stimulation factor (g-csf)
US5674495A (en) 1995-02-27 1997-10-07 Purdue Research Foundation Alginate-based vaccine compositions
AU695207B2 (en) * 1995-03-28 1998-08-06 Fidia Farmaceutici S.P.A. Nanospheres comprising a biocompatible polysaccharide
US5612053A (en) * 1995-04-07 1997-03-18 Edward Mendell Co., Inc. Controlled release insufflation carrier for medicaments
US5753622A (en) 1995-05-10 1998-05-19 University Technologies International, Inc. Use of epidermal growth factor as a gastrointestinal therapeutic agent
US5693775A (en) 1995-05-12 1997-12-02 The Johns Hopkins University School Of Medicine Fibroblast growth factor homologous factor-1 (FHF-1) and methods of use
JP3098401B2 (en) * 1995-07-12 2000-10-16 株式会社エルティーティー研究所 Formulation for nasal administration
GB9514438D0 (en) * 1995-07-14 1995-09-13 Danisco Stabilisation process and an enzyme for use in such a process
US5900238A (en) * 1995-07-27 1999-05-04 Immunex Corporation Vaccine delivery system
US5902796A (en) * 1995-09-22 1999-05-11 Carrington Laboratories, Inc. Bioactive factors of aloe vera plants
US5656734A (en) 1995-10-30 1997-08-12 Systems Bio-Industries Methods for making pectin and pectocellulosic products
GB9525083D0 (en) * 1995-12-07 1996-02-07 Danbiosyst Uk Vaccine compositions
GB9600272D0 (en) * 1996-01-06 1996-03-06 Univ Nottingham Polymers
US5840332A (en) 1996-01-18 1998-11-24 Perio Products Ltd. Gastrointestinal drug delivery system
US6231888B1 (en) * 1996-01-18 2001-05-15 Perio Products Ltd. Local delivery of non steroidal anti inflammatory drugs (NSAIDS) to the colon as a treatment for colonic polyps
US5760102A (en) 1996-02-20 1998-06-02 Carrington Laboratories, Inc. Uses of denture adhesive containing aloe extract
ATE260646T1 (en) * 1996-04-16 2004-03-15 Novartis Consumer Health Sa RAPID DISSOLVING ORAL DOSAGE FORM
DK0928207T4 (en) * 1996-07-10 2008-05-05 Coloplast As Adhesive and use of this agent
GB9707934D0 (en) * 1997-04-18 1997-06-04 Danbiosyst Uk Improved delivery of drugs to mucosal surfaces
US6210710B1 (en) * 1997-04-28 2001-04-03 Hercules Incorporated Sustained release polymer blend for pharmaceutical applications
US6197327B1 (en) * 1997-06-11 2001-03-06 Umd, Inc. Device and method for treatment of dysmenorrhea
US6416779B1 (en) * 1997-06-11 2002-07-09 Umd, Inc. Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections
US5874094A (en) * 1997-08-05 1999-02-23 Costello; Jeremiah Cream formulation for topical application
AR017512A1 (en) * 1997-08-22 2001-09-12 Smithkline Beecham Corp TABLETS OF QUICKLY DISPOSABLE METILCELLULOSE FOR ORAL ROUTE ADMINISTRATION AND PROCEDURE TO PREPARE THEM
NZ504108A (en) * 1997-09-26 2002-06-28 Noven Pharma Bioadhesive compositions comprising a polyvinylpyrrolidone polymer and methods for topical administration of active agents
JP4234803B2 (en) * 1997-10-27 2009-03-04 久光製薬株式会社 Pharmaceutical composition with controlled drug release rate
GB9725084D0 (en) * 1997-11-28 1998-01-28 Medeva Europ Ltd Vaccine compositions
DK1035833T3 (en) * 1997-12-02 2006-01-09 Archimedes Dev Ltd Composition for nasal administration
US6383495B1 (en) * 1997-12-08 2002-05-07 Council Of Scientific & Industrial Research Herbal formulation useful for treatment of skin disorders
GB9726916D0 (en) * 1997-12-19 1998-02-18 Danbiosyst Uk Nasal formulation
US6290964B1 (en) * 1998-03-06 2001-09-18 Kathleen Shupe Antimicrobial agents isolated from aloe vera
US6423345B2 (en) * 1998-04-30 2002-07-23 Acusphere, Inc. Matrices formed of polymer and hydrophobic compounds for use in drug delivery
US6313103B1 (en) * 1998-05-13 2001-11-06 Carrington Laboratories, Inc. Pectic substance as a growth factor stabilizer
US5929051A (en) * 1998-05-13 1999-07-27 Carrington Laboratories, Inc. Aloe pectins
FR2778566B1 (en) * 1998-05-15 2001-07-20 Sep Tarral PECTIC PREPARATIONS FOR USE AS MEDICINAL MEDIA
US6033651A (en) * 1998-06-10 2000-03-07 Revlon Consumer Products Corporation Gel cosmetic compositions
KR20000011247A (en) * 1998-07-23 2000-02-25 김윤 Composition and pharmaceutical dosage form for colonic drug delivery using polysaccharides
US6063915A (en) * 1998-07-30 2000-05-16 Hercules Incorporated Carrageenan compositions and methods for their production
US6080783A (en) * 1998-09-01 2000-06-27 Gum Tech International, Inc. Method and composition for delivering zinc to the nasal membrane
US6060078A (en) * 1998-09-28 2000-05-09 Sae Han Pharm Co., Ltd. Chewable tablet and process for preparation thereof
US6531152B1 (en) * 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
GB9828861D0 (en) * 1998-12-31 1999-02-17 Danbiosyst Uk Compositions
US6552024B1 (en) * 1999-01-21 2003-04-22 Lavipharm Laboratories Inc. Compositions and methods for mucosal delivery
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
DE60030418T2 (en) * 1999-03-17 2007-08-30 Coloplast A/S PRESSURE-SENSITIVE ADHESIVE COMPOSITION
US6375963B1 (en) * 1999-06-16 2002-04-23 Michael A. Repka Bioadhesive hot-melt extruded film for topical and mucosal adhesion applications and drug delivery and process for preparation thereof
GB9924797D0 (en) * 1999-10-20 1999-12-22 West Pharm Serv Drug Res Ltd Compound
ES2254164T3 (en) * 1999-10-29 2006-06-16 Nektar Therapeutics DRY POWDER COMPOSITIONS WITH IMPROVED DISPERSABILITY.
WO2003024427A1 (en) * 1999-12-20 2003-03-27 Temple University Of The Commonwealth System Of Higher Education Tableted oral extended release dosage form
DE60005469T3 (en) * 1999-12-22 2007-08-09 Dsm Ip Assets B.V. Pharmaceutical composition containing ascorbic acid and pectin
US7833549B2 (en) * 2000-01-19 2010-11-16 Mannkind Corporation Dry powder formulations of antihistamine for nasal administration
US6228387B1 (en) * 2000-01-27 2001-05-08 Murray Borod Integrated comprehensive hemorrhoid treatment compositions and regimen
JP4711520B2 (en) * 2000-03-21 2011-06-29 日本ケミカルリサーチ株式会社 Bioactive peptide-containing powder
US6368639B1 (en) * 2000-03-24 2002-04-09 Council Of Scientific And Industrial Research Herbal skin care formulation and a process for the preparation thereof
US6248360B1 (en) * 2000-06-21 2001-06-19 International Health Management Associates, Inc. Complexes to improve oral absorption of poorly absorbable antibiotics
US6365200B1 (en) * 2000-07-19 2002-04-02 Jason C. Birnholz Topical skin sensitizer
EP1320387B1 (en) * 2000-09-13 2012-04-11 Praecis Pharmaceuticals Incorporated Pharmaceutical compositions for sustained delivery of peptides
US6596297B2 (en) * 2000-10-30 2003-07-22 New York Blood Center, Inc. Biodegradable microbicidal vaginal barrier device
US6777000B2 (en) * 2001-02-28 2004-08-17 Carrington Laboratories, Inc. In-situ gel formation of pectin
MXPA04001768A (en) * 2001-09-03 2004-11-22 Dsm Ip Assets Bv Compositions comprising pectin and ascorbic acid.
BR0214279A (en) * 2001-11-19 2005-12-20 Becton Dickinson Co Pharmaceutical compositions in particulate form
JP2004002320A (en) * 2002-03-04 2004-01-08 Medorekkusu:Kk Liquid matrix causing in-vivo phase transition and liquid oral preparation

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4978528A (en) * 1986-06-23 1990-12-18 Bio Serae Laboratoires S.A. Process for preventing degradation of an anti-bacterial composition

Also Published As

Publication number Publication date
CN1874679A (en) 2006-12-06
WO2005023176A2 (en) 2005-03-17
CA2537290C (en) 2013-07-09
US7494669B2 (en) 2009-02-24
JP4765020B2 (en) 2011-09-07
JP2007504129A (en) 2007-03-01
EA200600484A1 (en) 2006-10-27
EP1663111A4 (en) 2009-10-21
KR20060127841A (en) 2006-12-13
US20050084534A1 (en) 2005-04-21
AU2004270101A1 (en) 2005-03-17
CA2537290A1 (en) 2005-03-17
EP1663111A2 (en) 2006-06-07
EA010351B1 (en) 2008-08-29

Similar Documents

Publication Publication Date Title
WO2005023176A3 (en) Delivery of physiologixal agents with in-situ gels comprising anionic polysaccharides
WO2002067897A3 (en) In-situ gel formation of pectins
EP2322215A3 (en) Combination treatment for non-hematologic malignancies using an anti-IGF-1R antibody
EP1790340A3 (en) Combination chemotherapy
WO2005039499A3 (en) Rapidly disintegrating film
EP2626368A3 (en) Insulin-oligomer conjugates, formulations and uses thereof
WO2004071529A3 (en) Uses of anti-insulin-like growth factor i receptor antibodies
IL192104A (en) Formulation suitable for subcutaneous administration comprising ctla4ig molecules, sugar and a pharmaceutically acceptable aqueous carrier and use thereof for preparation of a medicament
WO2009102467A3 (en) Devices, formulations, and methods for delivery of multiple beneficial agents
WO2002045684A3 (en) Rapidly dispersing pharmaceutical composition comprising effervescent agents
WO2007079147A3 (en) A delivery vehicle for probiotic bacteria comprising a dry matrix of polysaccharides, saccharides and polyols in a glass form and methods of making same
WO2009048945A8 (en) Rapid mucosal gel or film insulin compositions
WO2004070017A3 (en) Long-lasting, flavored dosage forms for sustained release of beneficial agents within the mouth
MY145790A (en) Composition
EP3492069A3 (en) Pharmaceutical compositions
MX2009003030A (en) Galenic form for the trans-mucosal delivery of active ingredients.
EP2402003A3 (en) Diclofenac formulations and methods of use
WO2006124681A3 (en) Oral drug delivery system and methods of use thereof
WO2006121522A3 (en) Implantable sensors and pumps, anti-scarring agents, and therapeutic compositions
WO2003047552A3 (en) Pharmaceutical composition comprising a 5ht1 receptor agonist
WO2004066983A3 (en) Controlled release of highly soluble agents
IL179177A (en) Pharmaceutical composition comprising acyclovir and a delivery agent, a dosage unit, use of acyclovir in the preparation of the pharmaceutical composition, use of the pharmaceutical composition in the preparation of a medicament and a method of preparing the pharmaceutical composition
ATE454136T1 (en) THERAPEUTIC COMPOSITIONS FOR PULMONARY ADMINISTRATION
WO2006050246A3 (en) Formulations of water insoluble or poorly water soluble drugs in lipidated glycosaminoglycan particles, their manufacturing and their use for diagnostics and therapy
HK1120417A1 (en) Stable nanoparticle formulations

Legal Events

Date Code Title Description
WWE Wipo information: entry into national phase

Ref document number: 200480024847.8

Country of ref document: CN

AK Designated states

Kind code of ref document: A2

Designated state(s): AE AG AL AM AT AU AZ BA BB BG BR BW BY BZ CA CH CN CO CR CU CZ DE DK DM DZ EC EE EG ES FI GB GD GE GH GM HR HU ID IL IN IS JP KE KG KP KR KZ LC LK LR LS LT LU LV MA MD MG MK MN MW MX MZ NA NI NO NZ OM PG PH PL PT RO RU SC SD SE SG SK SL SY TJ TM TN TR TT TZ UA UG UZ VC VN YU ZA ZM ZW

AL Designated countries for regional patents

Kind code of ref document: A2

Designated state(s): BW GH GM KE LS MW MZ NA SD SL SZ TZ UG ZM ZW AM AZ BY KG KZ MD RU TJ TM AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HU IE IT LU MC NL PL PT RO SE SI SK TR BF BJ CF CG CI CM GA GN GQ GW ML MR NE SN TD TG

121 Ep: the epo has been informed by wipo that ep was designated in this application
WWE Wipo information: entry into national phase

Ref document number: 2006524618

Country of ref document: JP

WWE Wipo information: entry into national phase

Ref document number: 2537290

Country of ref document: CA

Ref document number: 1020067004256

Country of ref document: KR

WWE Wipo information: entry into national phase

Ref document number: 2004270101

Country of ref document: AU

ENP Entry into the national phase

Ref document number: 2004270101

Country of ref document: AU

Date of ref document: 20040524

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 2004753044

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 1695/DELNP/2006

Country of ref document: IN

Ref document number: 200600484

Country of ref document: EA

WWP Wipo information: published in national office

Ref document number: 2004753044

Country of ref document: EP