WO2005032513A3 - Pantoprazole multiparticulate formulations - Google Patents
Pantoprazole multiparticulate formulations Download PDFInfo
- Publication number
- WO2005032513A3 WO2005032513A3 PCT/US2004/033058 US2004033058W WO2005032513A3 WO 2005032513 A3 WO2005032513 A3 WO 2005032513A3 US 2004033058 W US2004033058 W US 2004033058W WO 2005032513 A3 WO2005032513 A3 WO 2005032513A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- coat
- pantoprazole
- hypromellose
- multiparticulate formulations
- multiparticulates
- Prior art date
Links
- IQPSEEYGBUAQFF-UHFFFAOYSA-N Pantoprazole Chemical compound COC1=CC=NC(CS(=O)C=2NC3=CC=C(OC(F)F)C=C3N=2)=C1OC IQPSEEYGBUAQFF-UHFFFAOYSA-N 0.000 title abstract 3
- 229960005019 pantoprazole Drugs 0.000 title abstract 3
- 238000009472 formulation Methods 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 239000001866 hydroxypropyl methyl cellulose Substances 0.000 abstract 4
- 229920003088 hydroxypropyl methyl cellulose Polymers 0.000 abstract 4
- 235000010979 hydroxypropyl methyl cellulose Nutrition 0.000 abstract 4
- UFVKGYZPFZQRLF-UHFFFAOYSA-N hydroxypropyl methyl cellulose Chemical compound OC1C(O)C(OC)OC(CO)C1OC1C(O)C(O)C(OC2C(C(O)C(OC3C(C(O)C(O)C(CO)O3)O)C(CO)O2)O)C(CO)O1 UFVKGYZPFZQRLF-UHFFFAOYSA-N 0.000 abstract 2
- 229960003943 hypromellose Drugs 0.000 abstract 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 2
- 229960004048 pantoprazole sodium Drugs 0.000 abstract 1
- YNWDKZIIWCEDEE-UHFFFAOYSA-N pantoprazole sodium Chemical compound [Na+].COC1=CC=NC(CS(=O)C=2[N-]C3=CC=C(OC(F)F)C=C3N=2)=C1OC YNWDKZIIWCEDEE-UHFFFAOYSA-N 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000004094 surface-active agent Substances 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5084—Mixtures of one or more drugs in different galenical forms, at least one of which being granules, microcapsules or (coated) microparticles according to A61K9/16 or A61K9/50, e.g. for obtaining a specific release pattern or for combining different drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1611—Inorganic compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1617—Organic compounds, e.g. phospholipids, fats
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1635—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
Abstract
Priority Applications (18)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ZA2006/02682A ZA200602682B (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
CN200480035251.8A CN1886119B (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
RS20060238A RS54699B1 (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
CA2539982A CA2539982C (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
YUP-2006/0238A RS20060238A (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
ES04789540.4T ES2529570T3 (en) | 2003-10-01 | 2004-09-30 | Multiparticulate formulations of pantoprazole |
UAA200604671A UA83255C2 (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
PL04789540T PL1667660T3 (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
BRPI0415014A BRPI0415014A8 (en) | 2003-10-01 | 2004-09-30 | PANTOPRAZOLE MULTIPARTICLE FORMULATIONS, CAPSULES AND PACKAGING THAT COMPRISE THEM, METHOD OF PRODUCTION OF THE FORMULATIONS, USE AND COMPOSITION |
EP04789540.4A EP1667660B1 (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
AU2004278037A AU2004278037B2 (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
JP2006534330A JP4789806B2 (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulation |
US10/574,210 US7838027B2 (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
MXPA06003602 MX266708B (en) | 2003-10-01 | 2004-09-30 | FORMULATIONS OF PANTOPRAZOL MICROPARTICLES. |
KR1020067008414A KR101141508B1 (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
IL174432A IL174432A (en) | 2003-10-01 | 2006-03-21 | Pantoprazole multiparticulate formulations |
NO20061471A NO339714B1 (en) | 2003-10-01 | 2006-03-31 | Multiparticle pantoprazole and its use |
HK06109106.6A HK1086766A1 (en) | 2003-10-01 | 2006-08-16 | Pantoprazole multiparticulate formulations |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US50781003P | 2003-10-01 | 2003-10-01 | |
US60/507,810 | 2003-10-01 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2005032513A2 WO2005032513A2 (en) | 2005-04-14 |
WO2005032513A3 true WO2005032513A3 (en) | 2005-08-18 |
Family
ID=34421667
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2004/033058 WO2005032513A2 (en) | 2003-10-01 | 2004-09-30 | Pantoprazole multiparticulate formulations |
Country Status (29)
Country | Link |
---|---|
US (4) | US7544370B2 (en) |
EP (1) | EP1667660B1 (en) |
JP (1) | JP4789806B2 (en) |
KR (1) | KR101141508B1 (en) |
CN (1) | CN1886119B (en) |
AR (1) | AR045956A1 (en) |
AU (1) | AU2004278037B2 (en) |
BR (1) | BRPI0415014A8 (en) |
CA (1) | CA2539982C (en) |
CO (1) | CO5690538A2 (en) |
CR (1) | CR8318A (en) |
EC (1) | ECSP066538A (en) |
ES (1) | ES2529570T3 (en) |
GT (1) | GT200400194A (en) |
HK (1) | HK1086766A1 (en) |
IL (1) | IL174432A (en) |
MX (1) | MX266708B (en) |
MY (1) | MY147180A (en) |
NO (1) | NO339714B1 (en) |
NZ (1) | NZ581267A (en) |
PE (1) | PE20050960A1 (en) |
PL (1) | PL1667660T3 (en) |
RS (2) | RS54699B1 (en) |
RU (1) | RU2361574C2 (en) |
SG (1) | SG146656A1 (en) |
TW (1) | TWI372066B (en) |
UA (1) | UA83255C2 (en) |
WO (1) | WO2005032513A2 (en) |
ZA (1) | ZA200602682B (en) |
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CL2004000983A1 (en) | 2003-05-08 | 2005-03-04 | Altana Pharma Ag | ORAL PHARMACEUTICAL COMPOSITION IN THE FORM OF A TABLET THAT INCLUDES DIHYDRATED MAGNETIC PANTOPRAZOL, WHERE THE TABLET FORM IS COMPOSED BY A NUCLEUS, A MIDDLE COAT AND AN OUTER LAYER; AND USE OF PHARMACEUTICAL COMPOSITION IN ULCERAS AND |
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US8808736B2 (en) * | 2011-02-11 | 2014-08-19 | Zx Pharma, Llc | Enteric coated multiparticulate controlled release peppermint oil composition and related methods |
US8911780B2 (en) | 2011-02-11 | 2014-12-16 | Zx Pharma, Llc | Multiparticulate L-menthol formulations and related methods |
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CN102670528A (en) * | 2012-05-29 | 2012-09-19 | 海南卫康制药(潜山)有限公司 | Pantoprazole sodium lyophilized powder composition for injection and preparation method thereof |
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