WO2005084636A3 - A process for the preparation of controlled-release pharmaceutical composition of metoprolol - Google Patents

A process for the preparation of controlled-release pharmaceutical composition of metoprolol Download PDF

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Publication number
WO2005084636A3
WO2005084636A3 PCT/IB2005/000501 IB2005000501W WO2005084636A3 WO 2005084636 A3 WO2005084636 A3 WO 2005084636A3 IB 2005000501 W IB2005000501 W IB 2005000501W WO 2005084636 A3 WO2005084636 A3 WO 2005084636A3
Authority
WO
WIPO (PCT)
Prior art keywords
metoprolol
release pharmaceutical
pharmaceutical composition
controlled
preparation
Prior art date
Application number
PCT/IB2005/000501
Other languages
French (fr)
Other versions
WO2005084636A2 (en
Inventor
Rajeev Singh Raghuvanshi
Pramod Kharwade
Prashant Manohar Mandaogade
Ashok Rampal
Original Assignee
Ranbaxy Lab Ltd
Rajeev Singh Raghuvanshi
Pramod Kharwade
Prashant Manohar Mandaogade
Ashok Rampal
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ranbaxy Lab Ltd, Rajeev Singh Raghuvanshi, Pramod Kharwade, Prashant Manohar Mandaogade, Ashok Rampal filed Critical Ranbaxy Lab Ltd
Publication of WO2005084636A2 publication Critical patent/WO2005084636A2/en
Publication of WO2005084636A3 publication Critical patent/WO2005084636A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/138—Aryloxyalkylamines, e.g. propranolol, tamoxifen, phenoxybenzamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A61K9/2081—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets with microcapsules or coated microparticles according to A61K9/50
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
    • A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose

Abstract

The present invention relates to processes for preparing an oral controlled-release pharmaceutical composition of metoprolol succinate comprising a plurality of beads, which comprise a water soluble or water swellable inert core. Further, the present invention relates to processes of preparing oral controlled-release pharmaceutical compositions of metoprolol succinate comprising a plurality of beads, which comprise an inert core and one or more drug layers comprising metoprolol, wherein the soluble component of inert core and one or more drug layers comprise less than 95% w/w of a salt of metoprolol.
PCT/IB2005/000501 2004-02-27 2005-02-25 A process for the preparation of controlled-release pharmaceutical composition of metoprolol WO2005084636A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IN305DE2004 2004-02-27
IN305/DEL/2004 2004-02-27

Publications (2)

Publication Number Publication Date
WO2005084636A2 WO2005084636A2 (en) 2005-09-15
WO2005084636A3 true WO2005084636A3 (en) 2006-11-30

Family

ID=34917507

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/000501 WO2005084636A2 (en) 2004-02-27 2005-02-25 A process for the preparation of controlled-release pharmaceutical composition of metoprolol

Country Status (1)

Country Link
WO (1) WO2005084636A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE102005060393A1 (en) 2005-12-16 2007-06-21 Add Advanced Drug Delivery Technologies Ltd. Pharmaceutical pellet, useful for the production of tablet, comprises a spherical active agent, preferably metroprololsuccinate, comprising core with smooth surface and a coat on the core, where the active agent release is pH-independent
CN101516356A (en) * 2006-02-24 2009-08-26 特瓦制药工业有限公司 Metoprolol succinate e.r. tablets and methods for their preparation
JP5242576B2 (en) 2007-08-27 2013-07-24 旭化成ケミカルズ株式会社 Method for producing crystalline cellulose and granule-containing tablet
WO2013084089A1 (en) * 2011-12-09 2013-06-13 Wockhardt Limited Methods for treating cardiovascular disorder
CN102973515B (en) * 2012-11-28 2016-12-21 康普药业股份有限公司 One treats hypertension, anginal slow releasing preparation
CN104274387A (en) * 2013-07-03 2015-01-14 广东东阳光药业有限公司 Metoprolol slow-release composition
IN2013MU03221A (en) * 2013-10-14 2015-07-03 Zim Lab Ltd
CN105193757A (en) * 2014-06-23 2015-12-30 中国人民解放军军事医学科学院毒物药物研究所 Metoprolol sustained-release composition and preparation method thereof
CN111419813A (en) * 2020-05-09 2020-07-17 深圳市道科思医药有限公司 Metoprolol succinate sustained-release tablet and preparation method thereof
WO2022074681A1 (en) * 2020-10-08 2022-04-14 Harman Finochem Limited Pharmaceutical compositions with enhanced blend uniformity and content uniformity

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871549A (en) * 1985-07-19 1989-10-03 Fujisawa Pharmaceutical Co., Ltd. Time-controlled explosion systems and processes for preparing the same
US5246714A (en) * 1985-10-11 1993-09-21 Aktiebolaget Hassle Drug preparation
WO2003051340A1 (en) * 2001-12-19 2003-06-26 Astrazeneca Ab New film coating
US20030185887A1 (en) * 2002-03-28 2003-10-02 Chih-Ming Chen Controlled release oral dosage form of beta-adrenergic blocking agents
US20050008701A1 (en) * 2003-07-11 2005-01-13 Mongkol Sriwongjanva Formulation and process for drug loaded cores

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4871549A (en) * 1985-07-19 1989-10-03 Fujisawa Pharmaceutical Co., Ltd. Time-controlled explosion systems and processes for preparing the same
US5246714A (en) * 1985-10-11 1993-09-21 Aktiebolaget Hassle Drug preparation
WO2003051340A1 (en) * 2001-12-19 2003-06-26 Astrazeneca Ab New film coating
US20030185887A1 (en) * 2002-03-28 2003-10-02 Chih-Ming Chen Controlled release oral dosage form of beta-adrenergic blocking agents
US20050008701A1 (en) * 2003-07-11 2005-01-13 Mongkol Sriwongjanva Formulation and process for drug loaded cores

Also Published As

Publication number Publication date
WO2005084636A2 (en) 2005-09-15

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