WO2005118166A2 - Pharmaceutical composition containing irbesartan - Google Patents
Pharmaceutical composition containing irbesartan Download PDFInfo
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- WO2005118166A2 WO2005118166A2 PCT/IB2005/002689 IB2005002689W WO2005118166A2 WO 2005118166 A2 WO2005118166 A2 WO 2005118166A2 IB 2005002689 W IB2005002689 W IB 2005002689W WO 2005118166 A2 WO2005118166 A2 WO 2005118166A2
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- composition
- irbesartan
- tablet
- weight
- povidone
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4184—1,3-Diazoles condensed with carbocyclic rings, e.g. benzimidazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyethylene oxide, poloxamers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/10—Antioedematous agents; Diuretics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Definitions
- This application relates to pharmaceutical compositions containing irbesartan, and to pharmaceutical compositions containing irbesartan and hydrochlorothiazide.
- Irbesartan is chemically described as 2-butyl-3-[[29-(lH-tetrazol-5-yl) [1,19- biphenyl]-4-yl] methyl] 1, 3 -diazaspiro [4,4] non-l-en-4-one, also as 2-n-butyl-4- spirocyclopentane-l-[(2'-(tetrazol-5-yl)biphenyl-4-yl)methyl]-2-imidazolin-5-one, also as 2- butyl-3-[[2'-(l H-tetrazol-5-yl) [l,l'-biphenyl]-4-y]methyl]-l,3-diazaspiro [4,4] non-l-en-4- one. Its empirical formula is C 2 H 28 N 6 O, and it has the following structure:
- Irbesartan has a molecular weight of 428.5. The compound is described in U.S. Patent 5,270,317, which is incorporated herein in its entirety. [004] In the United States, irbesartan is available for oral administration tablets containing 75 mg, 150 mg, or 300 mg of irbesartan, which are sold under the trade name AVAPRO. The drug also is formulated as 150 and 300 mg tablets that also include 12.5 mg hydrochlorothiazide, which are sold under the trade name AVALLDE. [005] As noted in United States Patent 6,342,247, irbesartan is a fluffy material with relatively low bulk, and tap densities.
- irbesartan has certain undesirable flow characteristics. These properties make it difficult to formulate a large amount of the drug into a small tablet. Indeed, the '247 patent describes an oral formulation of irbesartan containing only up to 70% of the drug. Accordingly, there is a need for an improved formulation of irbesartan that contains a higher amount of the active ingredient.
- This invention relates to pharmaceutical compositions comprising irbesartan, providing oral formulations with a high relative amount or concentration of irbesartan.
- the present invention provides an oral formulation of irbesartan containing greater than 70% w/w irbesartan.
- the invention provides an oral formulation of irbesartan which exhibits a dissolution profile according to which greater than about 85% of the irbesartan is dissolved within about 30 minutes, preferably greater than about 80% of the irbesartan is dissolved within about 10 minutes, using USP apparatus 2, placing the tablet in lOOOmL of 0.1 N hydrochloric acid at 37°C with paddle speed of 50 rpm.
- the invention provides an oral formulation of two active pharmaceutical agents, irbesartan, and a diuretic, such as hydrochlorothiazide.
- a diuretic such as hydrochlorothiazide.
- the invention provides an oral formulation comprising irbesartan, and it provides an oral composition comprising irbesartan and hyhdrochlorothiazide.
- the irbesartan for inclusion in the inventive formulation can be manufactured according to any desired method, many of which are known to those of ordinary skill in the art. Examples of suitable methods to manufacture irbesartan are described in U.S. Patent 5,270,317, which is incorporated herein in its entirety. Hydrochlorothiazide is also well known and can be manufactured by methods known in the art.
- the invention provides an oral formulation comprising irbesartan that includes at least about 70% irbesartan w/w.
- the formulation includes at least about 75% w/w irbesartan, and more preferably the formulation includes from about 75% w/w to about 80%w/w irbesartan.
- a higher relative amount or concentration of irbesartan can be included, if desired.
- the invention provides an oral formulation comprising irbesartan which exhibits an improved dissolution profile according to the U.S. Pharmacopeia, using USP apparatus 2, placing the tablet in lOOOmL of 0.1N hydrochloric acid at 37°C with paddle speed of 50 rpm.
- the oral formulation comprising irbesartan exhibits a dissolution profile according to which greater than about 80% of the irbesartan is dissolved within about 10 minutes, and even more preferably greater than about 85% of the irbesartan is dissolved within about 10 minutes.
- the present invention provides, in another aspect, an oral formulation comprising irbesartan which exhibits a dissolution profile according to which at least about 75% of the irbesartan is dissolved within about 5 minutes, at least about 85% of the irbesartan is dissolved within about 10 minutes and at least about 95% of the irbesartan is dissolved in about 20 minutes.
- an oral formulation comprising irbesartan is provided which exhibits a dissolution profile according to which at least 97% of irbesartan is dissolved within 30 minutes.
- the oral formulation comprising irbesartan exhibits a dissolution profile according to which greater than about 85% of the irbesartan is dissolved within about 30 minutes.
- the oral formulation can include at least one additional active agent or combination of additional active agents.
- a preferred active agent to include in the formulation is a diuretic agent, such as hydrochlorothiazide, bendroflumethiazide, benzthiazide, chlorothiazide, chlorthalidone, cyclothiazide, hydroflumethiazide, methyclothiazide, metolazone, polythiazide, quinethazone, and trichlormethiazide.
- a diuretic is a thiazidic such as chlorothiazide and hydrochlorothiazide.
- Hydrochlorothiazide, the 3,4-dihydro derivative of chlorothiazide is the preferred diuretic for inclusion in the inventive composition.
- Hydrochlorothiazide can be prepared by methods known to those of skill in the art The amount of diuretic, such as hydrochlorothiazide is included in the formulation can be varied to achieve the desired therapeutic effect. In a preferred embodiment, the amount of diuretic is from about 3% to about 7% by weight of the formulation, more preferably, 3.32 to about 6.65% by weight of the formulation. The preferred diuretic is hydrochlorothiazide.
- the formulation contains at least one pharmaceutically acceptable excipient.
- excipient refers to pharmaceutically acceptable chemicals known to those of ordinary skill in the art of pharmacy to aid the administration of the medicinal agent.
- Preferable excipients for inclusion in the inventive formulation include binders, surfactants, diluents, disintegrants, antiadherents, and lubricants.
- the inventive composition comprises, one or more binders.
- Suitable "binders" can be selected from those capable of facilitating granulation of the irbesartan into larger, denser, and more free-flowing particles.
- Preferred binders include povidone (most preferably employed in the range of 1.0 - 7.0% by weight), pregelatinized starch (most preferably employed in the range of 1.0 - 10.0% by weight), algenic acid (most preferably employed in the range of 1.0 - 7.0% by weight) or sodium alginate (most preferably employed in the range of 1.0 - 5.0% by weight), cellulose or cellulose derivatives such as carboxymethylcellulose sodium (most preferably employed in the range of 1.0 - 6.0% by weight), ethylcellulose (most preferably employed in the range of 1.0 - 4.0% by weight), hydroxyethyl cellulose (most preferably employed in the range of 1.0 - 5.0%> by weight), hydroxypropyl cellulose (most preferably employed in the range
- the binder is povidone, most preferably, PVP K-30, and, where present, it can represent of from about 2.0%) w/w to about 2.15% w/w, most preferably 2.13% w/w, of the formulation.
- Another preferred binder is pregelatinized starch, most preferably, starch 1500 and, where present, the pregelatinized starch (starch 1500) typically represents from about 6.35%, most preferably, 6.38% w/w, and about 8.0 % w/w of the formulation.
- the inventive composition preferably includes at least one disintegrant.
- Suitable "disintegrants" can be selected from one or more components, which facilitate the break up of a tablet prepared from the composition when placed in contact with an aqueous medium. Any suitable disintegrant can be employed within the inventive formulation.
- Preferred disintegrant are croscarmellose sodium, such as Ac-Di-Sol (most preferably employed in the range of 1.0 - 7.0%> by weight), algenic acid (most preferably employed in the range of 1.0 - 7.0%) by weight) or sodium alginate (most preferably employed in the range of 1.0 - 7.0% by weight), carboxymethylcellulose sodium (most preferably employed in the range of 1.0 - 7.0%) by weight), crospovidone (most preferably employed in the range of 1.0 - 7.0%) by weight), sodium starch glycolate (most preferably employed in the range of 1.0 - 7.0%) by weight), pregelatinized starch (most preferably employed in the range of 1.0 - 7.0%) by weight).
- Ac-Di-Sol most preferably employed in the range of 1.0 - 7.0%> by weight
- algenic acid most preferably employed in the range of 1.0 - 7.0%) by weight
- sodium alginate most preferably employed in the range of 1.0 - 7.0% by weight
- croscarmellose typically croscarmellose.
- croscarmellose sodium (Ac-Di-Sol) represents from about 3.15%, preferably 3.19%, w/w to about 5.0%), preferably 4.0%, w/w of the formulation.
- the inventive composition preferably includes at least one surfactant.
- Suitable "surfactants” include compounds which aid in wetting so as to enhance dissolution. Any suitable surfactant can be employed in the inventive formulation.
- Preferred surfactants are sodium lauryl sulfate (most preferably employed in the range of 0.2-6.0%) by weight), poly(oxyethylene), poly(oxypropylene) block co-polymers such as poloxamers, especially Poloxamer 188 (most preferably employed in the range of 0.2-6.0%) by weight).
- the Poloxamer 188 typically represents from about 1.00%>, preferably 1.06%, w/w to about 2.0%) w/w of the formulation.
- the formulation preferably includes one or more diluents.
- Suitable "diluents" include compounds which are capable of providing bulk to obtain a desired mass, such as desired tablet mass. Any suitable diluent can be employed in the inventive formulation.
- Preferred diluents are microcrystalline cellulose, such as Avicel PH 102 FMC, inorganic phosphates such as dibasic calcium phosphate, sugars such as lactose hydrous or lactose anhydrous and mannitol. Diluents are preferably included in the range of 2-10%> by weight of the formulation. Where present, the microcrystalline cellulose typically represents from about 1% w/w to about 7.5% w/w of the formulation.
- microcrystalline cellulose For formulations that include only irbesartan as the active pharmaceutical agent, microcrystalline cellulose, where present, typically represents from about 1.9% w/w, to about 7.5% w/w of the formulation.
- microcrystalline cellulose For formulations which include irbesartan and diuretics, such as hydrochlorothiazide, as the active pharmaceutical agents, microcrystalline cellulose, when present, typically represents from about 1.9% w/w to about 6% w/w of the formulation.
- microcrystalline cellulose preferably is present in an amount of from about 1.97%) w/w to about 5.3% w/w of the formulation, preferably 5.29% w/w.
- microcrystalline cellulose preferably is present in an amount of from about 3.56%) w/w to about 5.96% w/w of the formulation.
- the inventive composition can further include at lease one antiadherent.
- Suitable "antiadherents” include compounds that contribute to the flowability of the formulation. Any suitable antiadherents can be employed in the inventive formulation.
- Preferred antiadherents are silicon dioxide, such as Syloid 244 (most preferably employed in the range of 0.2-2.0%) by weight) or talc (most preferably employed in the range of 0.5-5.0%) by weight). Where present, the silicon dioxide typically represents from about 0.4% w/w to about 0.5% w/w of the formulation.
- the composition of the present invention preferably includes at least one lubricant.
- Suitable "lubricants” include compounds that assist in preparing the desired form of the formulation for administration, such as tabletting. Any suitable lubricant can be employed in the inventive formulation.
- Preferred lubricants are fatty acids or fatty acid derivatives such as calcium stearate (most preferably employed in the range of 0.5-2.0%) by weight), glyceryl monostearate (most preferably employed in the range of 0.5-2.0% by weight), glyceryl palmitostearate (most preferably employed in the range of 0.5-2.0%) by weight), magnesium stearate (most preferably employed in the range of 0.2-2.0%) by weight), sodium lauryl sulfate (most preferably employed in the range of 0.5-2.0%» by weight), sodium stearyl fumarate (most preferably employed in the range of 0.5-2.0%) by weight), zinc stearate, stearic acid (most preferably employed in the range of 0.5-3.0%)
- the magnesium stearate represents from about 1.0% w/w to about 1.1% w/w of the formulation, preferably from about 1.0% w/w to about 1.06% w/w of the formulation.
- Preferred compositions according to the invention is set forth in Table 1 : TABLE 1
- the inventive formulation includes any form of irbesartan for oral administration, or any form of irbesartan and diuretic, such as hydrochlorothiazide, such as a tablet, caplet, capsule or the like.
- the preferred formulation is a tablet.
- tablets of the present invention contain (per tablet) 300mg of irbesartan.
- the total weight of the tablet preferably is between 376mg and 400mg.
- Formulations containing irbesartan can be prepared by any suitable method.
- a preferred method for forming a tablet formulation comprising irbesartan according to one embodiment of the present invention is by a wet granulation process.
- the irbesartan formulation can be prepared according to the following method: 1. Irbesartan is partially granulated with granulating solution of povidone in purified water using high shear mixer. 2. Pregelatinized starch is mixed with the mixture of step 1 in high shear mixer. 3. The blend of step 2 is granulated with a granulating solution of Poloxamer 188 in purified water using high shear mixer. 4. The granules formed in step 3 are dried in fluid bed dryer.
- Formulations that include irbesartan and a diuretic, such as hydrochlorothiazide, can include binders such as povidone, without a surfactant, and they can include binders such as povidone and surfactant, such as poloxamer, preferably Poloxamer 188.
- povidone comprises from about 2 to about 2.5%) w/w and preferably 2.13% w/w of a composition comprising irbesartan and diuretic such as hydrochlorothiazide.
- the composition comprises povidone in an amount of from about 2 to about 2.5% w/w, more preferably 2.13%> w/w of the composition, and poloxamer of from about 1 to about 1.2% w/w, more preferably 1.06% w/w of the composition.
- Formulations containing irbesartan and diuretic can be prepared by any suitable method.
- a preferred method for forming a tablet formulation comprising irbesartan and hydrochlorothiazide according to one embodiment of the present invention is by a wet granulation process.
- a formulation comprising irbesartan and hydrochlorothiazide can be prepared according to the following method: 1. Irbesartan and hydrochlorothiazide are mixed using high shear mixer. 2. Pregelatinized Starch is mixed with the mixture of step 1 in high shear mixer. 3. The mixture from step 2 is granulated with granulating solution of povidone in purified water using high shear mixer. 4.
- the granules are dried in fluid bed dryer. 5.
- the dried granules are sized by using oscillating granulator. 6.
- the milled dried granulate is mixed with microcrystalline cellulose, croscarmellose sodium and silicon dioxide in a blender. 7.
- the mixture of step 6 is mixed with magnesium stearate as a lubricant.
- the mixture from step 7 is mixed to form tablets using tablet press.
- a formulation comprising irbesartan and hydrochlorothiazide can be prepared according to the following method: 1. Irbesartan and hydrochlorothiazide are mixed using high shear mixer. 2. The mixture of step 1 is partially granulated with a granulating solution of povidone in purified water using high shear mixer. * 3. Pregelatinized Starch is mixed with the mixture of step 2 in high shear mixer. 4. The mixture from step 3 is granulated with granulating solution of Poloxamer 188 in purified water using high shear mixer. 5. The granules are dried in fluid bed dryer. 6. The dried granules are sized by using oscillating granulator. 7.
- the milled dried granulate is mixed with microcrystalline cellulose, croscarmellose sodium and silicon dioxide in a blender. 8.
- the mixture of step 7 is mixed with magnesium stearate as a lubricant.
- the mixture from step 8 is mixed to form tablets using tablet press.
- the tablets comprising irbesartan and hydrochlorothiazide prepared from the compositions of the present invention preferably contain (per tablet), 150 mg of irbesartan and 12.5 mg of hydrochlorothiazide, or 300mg of irbesartan and 12.5 mg of hydrochlorothiazide.
- the total weight of the tablet comprising 150 mg of irbesartan and 12.5 mg of hydrochlorothiazide is 188 mg and the total weight of the tablet comprising 300 mg irbesartan and 12.5 mg hydrochlorothiazide is 376mg to 400mg.
- Preferred compositions according to the invention comprising irbesartan and hydrochlorothiazide are as follows:
- This example illustrates the preparation of tablets containing 75%> irbesartan.
- Tablets containing irbesartan were prepared in three potencies using the composition of the present invention described in Table 2.
- tablets were prepared by an aqueous wet granulation process, in accordance with the method described above.
- the partial granulation of irbesartan with granulating solution of povidone in purified water was carried out in a high shear mixer (Diosna). This mixture was mixed with pregelatinized starch and then granulated with the granulating fluid of Poloxamer 188 in purified water.
- the granules obtained were dried in a fluid bed dryer until the loss-on-drying (LOD) was 1.5% or less.
- the dried granules were passed through an oscillating granulator.
- LOD loss-on-drying
- the milled granulates were mixed with the microcrystalline cellulose, croscarmellose sodium and silicon dioxide in a blender. The blend obtained was then mixed with magnesium stearate. By compressing the mixture using tabletting equipment, tablets were prepared for each potency having the composition as shown in Table 3.
- EXAMPLE 2 This example illustrates the preparation of tablets containing 80%> irbesartan.
- Tablets containing irbesartan were prepared in these potencies from the composition of present invention describe in Table 4.
- [0036] 75mg irbesartan with a total weight of 94mg per tablet.
- EXAMPLE 3 This example illustrates the preparation of tablets comprising irbesartan in an amount of approximately 80%> by weight of the formulation, and hydrochlorothiazide in an amount of approximately 3.32%> -6.65%> by weight of the formulation.
- Tablets containing irbesartan and hydrochlorothiazide were prepared in various potencies in accordance with the present invention as described in Table 6.
- the tablets a) comprisel50mg irbesartan and 12.5 mg hydrochlorothiazide with a total weight of 188mg per tablet and b) comprise 300mg irbesartan and 12.5 mg hydrochlorothiazide with a total weight of 376mg per tablet.
- tablets were prepared by wet granulation. Irbesartan and hydrochlorothiazide were mixed in a high shear mixer (Diosna). This mixture was mixed with pregelatinized starch and then granulated with the granulating fluid of povidone in purified water. The granules obtained were dried in a fluid bed dryer until the loss-on- drying (LOD) is 1.5% or less. The dried granules were passed through an oscillating granulator. The milled granulates were mixed with the microcrystalline cellulose, croscarmellose sodium and silicon dioxide in a blender. The blend obtained was then mixed with magnesium stearate. By compressing the mixture using tabletting equipment, tablets were prepared for each potency having the composition as shown in the table above.
- Liosna loss-on- drying
- This example illustrates another formulation containing irbesartan and hydrochlorothiazide in accordance with the invention.
- the formulations were made by wet granulation, as described above.
- EXAMPLE 5 This example illustrates another formulation containing irbesartan and hydrochlorothiazide in accordance with the invention. The formulations were made by wet granulation as described above. TABLE 8
- EXAMPLE 6 This example illustrates another formulation containing irbesartan and hydrochlorothiazide in accordance with the invention. The formulations were made by wet granulation as described above.
Abstract
Description
Claims
Priority Applications (8)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
AT05775601T ATE493973T1 (en) | 2004-06-04 | 2005-06-02 | PHARMACEUTICAL COMPOSITION CONTAINING IRBESARTAN |
EP05775601A EP1750862B1 (en) | 2004-06-04 | 2005-06-02 | Pharmaceutical composition containing irbesartan |
AU2005249794A AU2005249794A1 (en) | 2004-06-04 | 2005-06-02 | Pharmaceutical composition containing irbesartan |
DE602005025755T DE602005025755D1 (en) | 2004-06-04 | 2005-06-02 | IRBESARTAN PHARMACEUTICAL COMPOSITION CONTAINING |
JP2007514218A JP4880591B2 (en) | 2004-06-04 | 2005-06-02 | Pharmaceutical composition comprising irbesartan |
PL05775601T PL1750862T3 (en) | 2004-06-04 | 2005-06-02 | Pharmaceutical composition containing irbesartan |
CA2568640A CA2568640C (en) | 2004-06-04 | 2005-06-02 | Pharmaceutical composition containing irbesartan |
IL179718A IL179718A0 (en) | 2004-06-04 | 2006-11-30 | Pharmaceutical composition containing irbesartan |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US57742704P | 2004-06-04 | 2004-06-04 | |
US60/577,427 | 2004-06-04 |
Publications (2)
Publication Number | Publication Date |
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WO2005118166A2 true WO2005118166A2 (en) | 2005-12-15 |
WO2005118166A3 WO2005118166A3 (en) | 2006-07-27 |
Family
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Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
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PCT/IB2005/002689 WO2005118166A2 (en) | 2004-06-04 | 2005-06-02 | Pharmaceutical composition containing irbesartan |
Country Status (11)
Country | Link |
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US (2) | US8226977B2 (en) |
EP (1) | EP1750862B1 (en) |
JP (2) | JP4880591B2 (en) |
AT (1) | ATE493973T1 (en) |
AU (1) | AU2005249794A1 (en) |
CA (1) | CA2568640C (en) |
DE (1) | DE602005025755D1 (en) |
ES (1) | ES2282062T1 (en) |
IL (1) | IL179718A0 (en) |
PL (1) | PL1750862T3 (en) |
WO (1) | WO2005118166A2 (en) |
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DE102006006588A1 (en) * | 2006-02-13 | 2007-08-16 | Ratiopharm Gmbh | Fast-release irbesartan-containing pharmaceutical composition |
JP2008156258A (en) * | 2006-12-22 | 2008-07-10 | Ss Pharmaceut Co Ltd | Oral solid composition having covered bitterness |
EP2065035A1 (en) * | 2007-11-28 | 2009-06-03 | Laboratorios Lesvi, S.L. | Pharmaceutical formulations containing irbesartan |
JP2009541239A (en) * | 2006-06-23 | 2009-11-26 | ノバルティス アクチエンゲゼルシャフト | Galenic formulation of aliskiren and hydrochlorothiazide |
JP2010535212A (en) * | 2007-08-01 | 2010-11-18 | テバ ファーマシューティカル インダストリーズ リミティド | Improved candesartan formulation |
WO2011010316A1 (en) * | 2009-07-20 | 2011-01-27 | Hetero Research Foundation | Pharmaceutical compositions of irbesartan |
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EP1806130B1 (en) * | 2006-01-09 | 2010-03-31 | KRKA, D.D., Novo Mesto | Solid pharmaceutical composition comprising irbesartan |
GB0617171D0 (en) * | 2006-08-31 | 2006-10-11 | Generics Uk Ltd | Novel compositions and methods |
CA2563690C (en) * | 2006-10-12 | 2014-10-07 | Pharmascience Inc. | Pharmaceutical compositions comprising intra- and extra- granular fractions |
WO2008102235A1 (en) * | 2007-02-20 | 2008-08-28 | Aurobindo Pharma Limited | Controlled release formulations of alfuzosin |
JP5296456B2 (en) * | 2008-08-26 | 2013-09-25 | 大日本住友製薬株式会社 | Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet |
WO2011141783A2 (en) | 2010-04-13 | 2011-11-17 | Micro Labs Limited | Pharmaceutical composition comprising irbesartan |
JP5946135B2 (en) * | 2012-03-29 | 2016-07-05 | 塩野義製薬株式会社 | Solid formulation containing trichloromethiazide and crystalline cellulose |
JP6018420B2 (en) * | 2012-06-05 | 2016-11-02 | ニプロ株式会社 | Pharmaceutical composition comprising an angiotensin II receptor antagonist and thiazide diuretic |
KR20140030505A (en) * | 2012-08-31 | 2014-03-12 | 한미약품 주식회사 | Pharmaceutical composite capsule formulation comprising irbesartan and hmg-coa reductase inhibitor |
JP5714652B2 (en) * | 2013-06-13 | 2015-05-07 | 大日本住友製薬株式会社 | Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet |
JP5978335B2 (en) * | 2015-03-11 | 2016-08-24 | 大日本住友製薬株式会社 | Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet |
JP6445923B2 (en) * | 2015-04-22 | 2018-12-26 | ダイト株式会社 | Preparation of irbesartan-containing tablets |
JP6737060B2 (en) * | 2015-09-11 | 2020-08-05 | ニプロ株式会社 | Method for producing pharmaceutical composition containing irbesartan |
JP6151413B2 (en) * | 2016-07-25 | 2017-06-21 | 大日本住友製薬株式会社 | Irbesartan-containing pharmaceutical composition with good dissolution and orally disintegrating tablet |
NZ755597A (en) | 2017-02-17 | 2023-06-30 | Eidos Therapeutics Inc | Processes for preparing ag-10, its intermediates, and salts thereof |
JP2017141299A (en) * | 2017-05-24 | 2017-08-17 | 大日本住友製薬株式会社 | Irbesartan-containing pharmaceutical composition showing excellent elution, and orally disintegrable tablet |
JP2018168185A (en) * | 2018-07-05 | 2018-11-01 | 大日本住友製薬株式会社 | Irbesartan-containing pharmaceutical composition and orally disintegrable tablet with excellent elution |
JP2019203031A (en) * | 2019-09-06 | 2019-11-28 | 大日本住友製薬株式会社 | Irbesartan-containing pharmaceutical composition showing excellent elution, and orally disintegrable tablet |
Family Cites Families (371)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4327080A (en) | 1981-07-13 | 1982-04-27 | E. R. Squibb & Sons, Inc. | Novel Bendroflumethiazide formulations and method |
US5002776A (en) | 1983-12-22 | 1991-03-26 | Elan Corporation, Plc | Controlled absorption diltiazem formulations |
GB8608335D0 (en) | 1986-04-04 | 1986-05-08 | Pfizer Ltd | Pharmaceutically acceptable salts |
US4808413A (en) | 1987-04-28 | 1989-02-28 | E. R. Squibb & Sons, Inc. | Pharmaceutical compositions in the form of beadlets and method |
US5049394A (en) | 1987-09-11 | 1991-09-17 | E. R. Squibb & Sons, Inc. | Pharmaceutical composition containing high drug load and method for preparing same |
US5744166A (en) | 1989-02-25 | 1998-04-28 | Danbiosyst Uk Limited | Drug delivery compositions |
US5212165A (en) | 1989-10-23 | 1993-05-18 | E. R. Squibb & Sons, Inc. | Method for rehabilitating the vasorelaxant action of the coronary arteries impaired through atherosclerosis or hypercholesterolemia employing an ace inhibitor |
US5707644A (en) | 1989-11-04 | 1998-01-13 | Danbiosyst Uk Limited | Small particle compositions for intranasal drug delivery |
US5270317A (en) | 1990-03-20 | 1993-12-14 | Elf Sanofi | N-substituted heterocyclic derivatives, their preparation and the pharmaceutical compositions in which they are present |
FR2665702B1 (en) | 1990-08-08 | 1994-02-25 | Sanofi | N-SUBSTITUTED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. |
PT97078B (en) | 1990-03-20 | 1997-07-31 | Sanofi Sa | PROCESS FOR THE PREPARATION OF N-SUBSTITUTED HETEROCYCLIC DERIVATIVES AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
FR2681067B1 (en) | 1991-09-10 | 1993-12-17 | Elf Sanofi | N-SUBSTITUTED HETEROCYCLIC DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. |
FR2659967B1 (en) | 1990-03-20 | 1992-07-24 | Sanofi Sa | N-SUBSTITUTED IMIDAZOLINONE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING SAME. |
US5298497A (en) | 1990-05-15 | 1994-03-29 | E. R. Squibb & Sons, Inc. | Method for preventing onset of hypertension employing a cholesterol lowering drug |
US5140012A (en) | 1990-05-31 | 1992-08-18 | E. R. Squibb & Sons, Inc. | Method for preventing onset of restenosis after angioplasty employing pravastatin |
US5622985A (en) | 1990-06-11 | 1997-04-22 | Bristol-Myers Squibb Company | Method for preventing a second heart attack employing an HMG CoA reductase inhibitor |
US5137902A (en) | 1990-07-13 | 1992-08-11 | E. I. Du Pont De Nemours And Company | 4-alkylimidazole derivatives and anti-hypertensive use thereof |
US5089626A (en) | 1990-08-23 | 1992-02-18 | Merck & Co., Inc. | Process for preparing an angiotensin II antagonist |
US5032578A (en) | 1990-09-17 | 1991-07-16 | E. R. Squibb & Sons, Inc. | Method for preventing or treating depression employing a combination of an ace inhibitor and a drug that acts at serotonin receptors |
US5098889A (en) | 1990-09-17 | 1992-03-24 | E. R. Squibb & Sons, Inc. | Method for preventing or inhibiting loss of cognitive function employing a combination of an ace inhibitor and a drug that acts at serotonin receptors |
US6034114A (en) | 1990-12-14 | 2000-03-07 | Smithkline Beecham Plc | Medicament |
WO1992010097A1 (en) | 1990-12-14 | 1992-06-25 | Smithkline Beecham Corporation | Angiotensin ii receptor blocking compositions |
US6025380A (en) | 1990-12-14 | 2000-02-15 | Smithkline Beecham Plc | Medicament |
US20010016594A1 (en) | 1990-12-14 | 2001-08-23 | Smithkline Beecham P.L.C. | Medicament |
US6028091A (en) | 1990-12-14 | 2000-02-22 | Smithkline Beecham Plc | Medicament |
US5472967A (en) | 1991-02-20 | 1995-12-05 | Synthelabo | 4-pyrimidinone derivatives their preparation and their application in therapy |
FR2673427B1 (en) | 1991-03-01 | 1993-06-18 | Sanofi Elf | N-SUBSTITUTED DIAZOTATED HETEROCYCLIC DERIVATIVES BY A BIPHENYLMETHYL GROUP, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. |
FR2677984B1 (en) | 1991-06-21 | 1994-02-25 | Elf Sanofi | N-SUBSTITUTED IMIDAZOLINE DERIVATIVES, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME. |
EP0521388B1 (en) | 1991-07-01 | 1995-05-10 | Gerhard Dr. Gergely | Process for the preparation of a pharmaceutical preparation containing at least two different actives and use thereof |
AU2494792A (en) | 1991-08-19 | 1993-03-16 | E.I. Du Pont De Nemours And Company | Angiotensin ii receptor blocking imidazolinone derivatives |
CZ36294A3 (en) | 1991-08-19 | 1994-07-13 | Du Pont | Substituted imidazilonone derivatives and pharmaceutical preparations based thereon |
DE69331839T2 (en) | 1992-01-29 | 2002-12-12 | Takeda Chemical Industries Ltd | Fast-dissolving tablet and its manufacture |
FR2688781B1 (en) | 1992-03-23 | 1994-07-01 | Sanofi Elf | IMIDAZOLINES N-SUBSTITUTED BY A BIPHENYLMETHYL GROUP, THEIR PREPARATION, THE PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. |
GB9208116D0 (en) | 1992-04-13 | 1992-05-27 | Ici Plc | Therapeutic agents |
US6673824B1 (en) | 1992-05-06 | 2004-01-06 | Bristol-Myers Squibb Co. | Phenyl sulfonamide endothelin antagonists |
EP0577023A3 (en) | 1992-07-01 | 1996-12-18 | Hoechst Ag | Angiotensin-ii receptor-antagonists for the treatment of arrhythmices |
US5472711A (en) | 1992-07-30 | 1995-12-05 | Edward Mendell Co., Inc. | Agglomerated hydrophilic complexes with multi-phasic release characteristics |
AU5449194A (en) | 1992-10-26 | 1994-05-24 | Merck & Co., Inc. | Combinations of angiotensin-ii receptor antagonists and diuretics |
US5457112A (en) | 1992-12-14 | 1995-10-10 | Synthelabo | 3-(6-quinolylmethyl)-4H-imidazol-4-one derivatives, their preparation and their application in therapy |
WO1994018954A1 (en) | 1993-02-22 | 1994-09-01 | Vivorx Pharmaceuticals, Inc. | Methods for in vivo delivery of biologics and compositions useful therefor |
US5914132A (en) | 1993-02-26 | 1999-06-22 | The Procter & Gamble Company | Pharmaceutical dosage form with multiple enteric polymer coatings for colonic delivery |
EP0635263A3 (en) | 1993-06-28 | 1995-09-27 | American Cyanamid Co | Angiotensin (AII) antagonists as inhibitors of the growth of adipose tissue. |
FR2708608B1 (en) | 1993-07-30 | 1995-10-27 | Sanofi Sa | N-sulfonylbenzimidazolone derivatives, their preparation, pharmaceutical compositions containing them. |
FR2708606B1 (en) | 1993-07-30 | 1995-10-27 | Sanofi Sa | N-phenylalkylindol-2-one derivatives, their preparation, pharmaceutical compositions containing them. |
US5514670A (en) | 1993-08-13 | 1996-05-07 | Pharmos Corporation | Submicron emulsions for delivery of peptides |
US5824696A (en) | 1993-09-01 | 1998-10-20 | Smithkline Beecham Corporation | Medicaments |
US6174917B1 (en) | 1993-09-08 | 2001-01-16 | Pharmacy And Therapeutic Advisory Consultancy Ltd. | Method of treating liver disease and like indications with vasodilating agents |
US5464854A (en) | 1993-11-11 | 1995-11-07 | Depadova; Anathony S. | Method of modifying ovarian hormone-regulated AT1 receptor activity as treatment of incapacitating symptom(s) of P.M.S. |
JPH09510182A (en) | 1993-11-17 | 1997-10-14 | エルディーエス・テクノロジーズ・インコーポレーテッド | Encapsulated transparent liquid for drug delivery |
US5536505A (en) | 1993-12-15 | 1996-07-16 | Eastman Chemical Company | Controlled release matrix system using cellulose acetate/poly-2-ethyl-2-oxazoline blends |
US5523095A (en) | 1993-12-15 | 1996-06-04 | Eastman Chemical Company | Controlled release matrix system using cellulose acetate/polyvinylpyrrolidone blends |
DK0743852T3 (en) | 1994-02-08 | 2005-10-17 | Novartis Ag | Treatment of normal pressure glaucoma with valsartan |
JP3414539B2 (en) | 1994-05-11 | 2003-06-09 | 有限会社ドット | Composition for nasal absorption |
US6645463B1 (en) | 1994-05-16 | 2003-11-11 | The Board Of Regents Of The University Of Michigan | Blood-pool selective carrier for lipophilic imaging agents |
US5464633A (en) | 1994-05-24 | 1995-11-07 | Jagotec Ag | Pharmaceutical tablets releasing the active substance after a definite period of time |
US5541209A (en) | 1994-08-22 | 1996-07-30 | Bristol-Myers Squibb Company | Method of treating or preventing cardiac arrhythmia employing an N-substituted heterocyclic derivative |
US5612359A (en) | 1994-08-26 | 1997-03-18 | Bristol-Myers Squibb Company | Substituted biphenyl isoxazole sulfonamides |
FR2725987B1 (en) | 1994-10-19 | 1997-01-10 | Sanofi Sa | PROCESS FOR THE PREPARATION OF A TETRAZOLE DERIVATIVE IN TWO CRYSTALLINE FORMS AND NOVEL CRYSTALLINE FORM THEREOF |
US6485726B1 (en) | 1995-01-17 | 2002-11-26 | The Brigham And Women's Hospital, Inc. | Receptor specific transepithelial transport of therapeutics |
US5780473A (en) | 1995-02-06 | 1998-07-14 | Bristol-Myers Squibb Company | Substituted biphenyl sulfonamide endothelin antagonists |
CA2168066A1 (en) | 1995-02-08 | 1996-08-09 | James R. Powell | Treatment of hypertension and congestive heart failure |
FR2732223B1 (en) | 1995-03-30 | 1997-06-13 | Sanofi Sa | PHARMACEUTICAL COMPOSITION FOR TRANSDERMAL ADMINISTRATION |
US5731339A (en) * | 1995-04-28 | 1998-03-24 | Zonagen, Inc. | Methods and formulations for modulating the human sexual response |
US20020094346A1 (en) | 1995-05-17 | 2002-07-18 | M. D. Henry C. Lin | Method and compositions for improving digestion and absorption in the small intestine |
US5686106A (en) | 1995-05-17 | 1997-11-11 | The Procter & Gamble Company | Pharmaceutical dosage form for colonic delivery |
SE9501881D0 (en) | 1995-05-19 | 1995-05-19 | Astra Ab | New pharmacological use of AII receptor antagonists |
US5645839A (en) | 1995-06-07 | 1997-07-08 | Trustees Of Boston University | Combined use of angiotensin inhibitors and nitric oxide stimulators to treat fibrosis |
US5994348A (en) | 1995-06-07 | 1999-11-30 | Sanofi | Pharmaceutical compositions containing irbesartan |
ES2167571T3 (en) | 1995-06-07 | 2002-05-16 | Searle & Co | ANTIGONIST COMBINATION THERAPY OF ALDOSTERONE EPOXY-STEROID AND ANGIOTENSIN II ANTAGONIST FOR THE TREATMENT OF CONGESTIVE CARDIAC FAILURE. |
TW442301B (en) | 1995-06-07 | 2001-06-23 | Sanofi Synthelabo | Pharmaceutical compositions containing irbesartan |
FR2735365B1 (en) | 1995-06-14 | 1997-09-05 | Sanofi Sa | USE OF AN ANGIOTENSIN II ANTAGONIST AND A BENZOFURANE DERIVATIVE FOR THE PREPARATION OF A MEDICAMENT USEFUL IN THE TREATMENT OF CARDIOVASCULAR CONDITIONS |
SE9502219D0 (en) | 1995-06-19 | 1995-06-19 | Astra Ab | Novel medical use |
US6057139A (en) * | 1995-06-29 | 2000-05-02 | Mcneil-Ppc, Inc. | Preblend of microcrystalline cellulose and lactase for making tablets |
US5846990A (en) | 1995-07-24 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
FR2740136B1 (en) | 1995-10-24 | 1998-01-09 | Sanofi Sa | INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
FR2740686B1 (en) | 1995-11-03 | 1998-01-16 | Sanofi Sa | STABLE LYOPHILIZED PHARMACEUTICAL FORMULATION |
AU1791497A (en) | 1996-02-29 | 1997-09-16 | Novartis Ag | At1 receptor antagonist for the stimulation of apoptosis |
FR2746013B1 (en) | 1996-03-18 | 1998-05-29 | Sanofi Sa | USE OF ANTIARRHYTHMIC COMPOUNDS IN THE PREVENTION OF POST INFARCT MORTALITY |
US5939446A (en) | 1996-04-09 | 1999-08-17 | Bristol-Myers Squibb Co. | Heteroaryl substituted phenyl isoxazole sulfonamide endothelin antagonists |
AU714618B2 (en) | 1996-07-15 | 2000-01-06 | Sankyo Company Limited | Medicinal composition |
US5891469A (en) | 1997-04-02 | 1999-04-06 | Pharmos Corporation | Solid Coprecipitates for enhanced bioavailability of lipophilic substances |
HRP970493A2 (en) | 1996-09-23 | 1998-08-31 | Wienman E. Phlips | Oral delayed immediate release medical formulation and method for preparing the same |
ATE314097T1 (en) | 1996-10-28 | 2006-01-15 | Amersham Health As | CONTRAST AGENTS |
US6008221A (en) | 1996-11-06 | 1999-12-28 | Bristol-Myers Squibb Company | Method for treating Alzheimer's disease with folic acid |
US6019988A (en) | 1996-11-18 | 2000-02-01 | Bristol-Myers Squibb Company | Methods and compositions for enhancing skin permeation of drugs using permeation enhancers, when drugs and/or permeation enhancers are unstable in combination during long-term storage |
FR2757157B1 (en) | 1996-12-13 | 1999-12-31 | Sanofi Sa | INDOLIN-2-ONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM |
US6201002B1 (en) | 1997-01-10 | 2001-03-13 | Merck & Co., Inc. | Method for reducing mortality with an angiotensin II antagonist |
EP0855392A3 (en) | 1997-01-22 | 2000-01-05 | Hoechst Aktiengesellschaft | Five-membered heterocycles having biphenylsulphonyl substituents, processes for the preparation thereof, their use as medicaments or diagnostic agent and medicaments containing them |
US5788987A (en) | 1997-01-29 | 1998-08-04 | Poli Industria Chimica Spa | Methods for treating early morning pathologies |
TW536540B (en) | 1997-01-30 | 2003-06-11 | Bristol Myers Squibb Co | Endothelin antagonists: N-[[2'-[[(4,5-dimethyl-3-isoxazolyl)amino]sulfonyl]-4-(2-oxazolyl)[1,1'-biphenyl]-2-yl]methyl]-N,3,3-trimethylbutanamide and N-(4,5-dimethyl-3-isoxazolyl)-2'-[(3,3-dimethyl-2-oxo-1-pyrrolidinyl)methyl]-4'-(2-oxazolyl)[1,1'-biphe |
WO1998033781A1 (en) | 1997-01-30 | 1998-08-06 | Bristol-Myers Squibb Company | Method for preventing or treating low renin hypertension by administering an endothelin antagonist |
US5846985A (en) | 1997-03-05 | 1998-12-08 | Bristol-Myers Squibb Co. | Substituted biphenyl isoxazole sulfonamides |
TW580397B (en) | 1997-05-27 | 2004-03-21 | Takeda Chemical Industries Ltd | Solid preparation |
DE19724696A1 (en) | 1997-06-12 | 1998-12-24 | Hexal Ag | Pharmaceutical preparation with three types of pellets |
CA2295177C (en) | 1997-06-13 | 2007-01-09 | Medinova Medical Consulting Gmbh | Drug targeting system, method of its preparation and its use |
IT1292437B1 (en) | 1997-06-30 | 1999-02-08 | Zambon Spa | ORTHO-METALLATION PROCESS USEFUL FOR THE SYNTHESIS OF 1 - TETRAZOL- 5-IL) 2-SUBSTITUTED BENZENES |
HU218679B (en) | 1997-07-25 | 2000-10-28 | Sanofi-Synthelabo | Process for preparation of imidazolones and intermediates thereof |
US20010044584A1 (en) | 1997-08-28 | 2001-11-22 | Kensey Kenneth R. | In vivo delivery methods and compositions |
GT199800126A (en) | 1997-08-29 | 2000-01-29 | COMBINATION THERAPY. | |
NL1006903C2 (en) * | 1997-09-01 | 1999-03-04 | Johannes Gerardus Van Gemert | Method for compacting molding sand. |
EP0942780B1 (en) | 1997-09-09 | 2003-07-30 | Select Release, L.C. | Coated particles, methods of making and using |
US6248358B1 (en) | 1998-08-25 | 2001-06-19 | Columbia Laboratories, Inc. | Bioadhesive progressive hydration tablets and methods of making and using the same |
US20030077229A1 (en) | 1997-10-01 | 2003-04-24 | Dugger Harry A. | Buccal, polar and non-polar spray or capsule containing cardiovascular or renal drugs |
DE69830069T3 (en) | 1997-10-17 | 2012-02-09 | Ark Therapeutics Ltd. | USE OF INHIBITORS OF THE RENIN-ANGIOTENSIN SYSTEM FOR THE TREATMENT OF HYPOXIA OR REDUCED METABOLIC CHANGE |
DE19750529A1 (en) | 1997-11-14 | 1999-05-20 | Basf Ag | New heterocyclic alpha-hydroxycarboxylic acid derivatives useful for treating hypertension, chronic coronary insufficiency, asthma, prostate cancer etc. |
JPH11137208A (en) | 1997-11-14 | 1999-05-25 | Nikken Chem Co Ltd | Solid material rapidly soluble in oral cavity and its production |
CN100379407C (en) * | 1997-12-19 | 2008-04-09 | 史密丝克莱恩比彻姆公司 | Process for manufacturing bite-dispersion tablets |
US6162922A (en) | 1998-01-30 | 2000-12-19 | Bristol-Myers Squibb Co. | Method for preparing N-substituted heterocyclic derivatives using a phase-transfer catalyst |
HRP980532B1 (en) | 1998-10-02 | 2005-06-30 | Pliva | Novel crystalline torasemide modification |
AU747110B2 (en) | 1998-02-25 | 2002-05-09 | Merck & Co., Inc. | Method for decreasing QT dispersion or inhibiting the progression of QT dispersion with an angiotensin II receptor antagonist |
ATE258430T1 (en) | 1998-03-04 | 2004-02-15 | Takeda Chemical Industries Ltd | PREPARATION WITH DELAYED RELEASE FOR AII ANTAGONISTS, THEIR PRODUCTION AND USE |
FR2775598A1 (en) | 1998-03-06 | 1999-09-10 | Sanofi Sa | PHARMACEUTICAL COMPOSITIONS COMPRISING A SELECTIVE ANTAGONIST OF ARGININE-VASOPRESSIN V1A RECEPTORS AND A SELECTIVE ANTAGONIST OF ARGININE-VASOPRESSIN V2 RECEPTORS |
US6284363B1 (en) | 1998-03-23 | 2001-09-04 | Fuji Polymer Industries Co., Ltd. | Electromagnetic wave absorbing thermoconductive silicone gel molded sheet and method for producing the same |
US20040062802A1 (en) | 1998-04-02 | 2004-04-01 | Hermelin Victor M. | Maximizing effectiveness of substances used to improve health and well being |
FR2778103A1 (en) | 1998-04-29 | 1999-11-05 | Sanofi Sa | PHARMACEUTICAL COMPOSITIONS CONTAINING IN ASSOCIATION A V1A ARGININE-VASOPRESSIN ANTAGONIST AND AN ANGIOTENSIN II AT1 RECEPTOR ANTAGONIST |
AU766831B2 (en) | 1998-05-11 | 2003-10-23 | Takeda Pharmaceutical Company Limited | Oxyiminoalkanoic acid derivatives with hypoglycemic and hypolipidemic activity |
AU750122C (en) | 1998-06-17 | 2003-02-27 | Bristol-Myers Squibb Company | Preventing cerebral infarction through administration of ADP-receptor antiplatelet and antihypertensive drugs in combination |
IT1301759B1 (en) | 1998-06-19 | 2000-07-07 | Nicox Sa | NITRATED SALTS OF ANTI-HYPERTENSIVE DRUGS |
FR2780403B3 (en) * | 1998-06-24 | 2000-07-21 | Sanofi Sa | NOVEL FORM OF IRBESARTAN, METHODS FOR OBTAINING SAID FORM AND PHARMACEUTICAL COMPOSITIONS CONTAINING THE SAME |
US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
FR2780890B3 (en) | 1998-07-10 | 2000-09-01 | Sanofi Sa | USE OF A PHARMACEUTICAL COMPOSITION CONTAINING, IN COMBINATION, AN ANTAGONIST OF ANGIOTENSIN II AT1 RECEPTORS AND INDOMETHACIN FOR THE TREATMENT OF CHRONIC GLOMERULONEPHRITES |
TW585786B (en) | 1998-07-28 | 2004-05-01 | Takeda Chemical Industries Ltd | Lansoprazole-containing rapidly disintegrable solid pharmaceutical composition |
AU5403499A (en) | 1998-08-26 | 2000-03-21 | Queen's University At Kingston | Methods for remodeling neuronal and cardiovascular pathways |
US6489307B1 (en) | 1998-09-14 | 2002-12-03 | University Of Florida | Antisense compositions targeted to β1-adrenoceptor-specific mRNA and methods of use |
FR2783422A1 (en) | 1998-09-21 | 2000-03-24 | Sanofi Sa | Composition for reducing treating hypertension or platelet aggregation disorders, contains angiotensin II receptor antagonist and platelet anti-aggregation agent |
US6531152B1 (en) | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
US7815937B2 (en) | 1998-10-27 | 2010-10-19 | Biovail Laboratories International Srl | Quick dissolve compositions and tablets based thereon |
US6596747B2 (en) | 1998-10-29 | 2003-07-22 | Bristol-Myers Squibb Company | Compounds derived from an amine nucleus and pharmaceutical compositions comprising same |
US20040141925A1 (en) | 1998-11-12 | 2004-07-22 | Elan Pharma International Ltd. | Novel triamcinolone compositions |
CA2350706A1 (en) | 1998-11-13 | 2000-05-25 | Elan Pharma International Limited | Drug delivery systems and methods |
TNSN99224A1 (en) | 1998-12-01 | 2005-11-10 | Inst For Pharm Discovery Inc | METHODS OF REDUCING GLUCOSE AND TRIGLYCERIDE LEVELS IN SERUM AND FOR ANTIGENESIS SUPPRESSION USING INDOLEALKANOIC ACIDS |
FR2787330A1 (en) | 1998-12-18 | 2000-06-23 | Sanofi Sa | Compositions containing an immunosuppressant and an AT1 angiotensin II receptor antagonist, for prevention and treatment of vascular complications due to graft rejection |
KR100349597B1 (en) | 1999-01-12 | 2002-08-22 | 삼성전자 주식회사 | Optical wave-guide device and manufacturing method thereof |
US20030104048A1 (en) | 1999-02-26 | 2003-06-05 | Lipocine, Inc. | Pharmaceutical dosage forms for highly hydrophilic materials |
US6294192B1 (en) | 1999-02-26 | 2001-09-25 | Lipocine, Inc. | Triglyceride-free compositions and methods for improved delivery of hydrophobic therapeutic agents |
US7374779B2 (en) | 1999-02-26 | 2008-05-20 | Lipocine, Inc. | Pharmaceutical formulations and systems for improved absorption and multistage release of active agents |
US6248363B1 (en) | 1999-11-23 | 2001-06-19 | Lipocine, Inc. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
EP1169322B8 (en) | 1999-03-08 | 2006-09-13 | Medicure Inc. | Pyridoxal analogues for the treatment of disorders caused by a deficiency in vitamin b6 |
JP3695978B2 (en) | 1999-03-16 | 2005-09-14 | 三洋電機株式会社 | Alkaline storage battery with spiral electrode body |
US6548529B1 (en) | 1999-04-05 | 2003-04-15 | Bristol-Myers Squibb Company | Heterocyclic containing biphenyl aP2 inhibitors and method |
US6383471B1 (en) | 1999-04-06 | 2002-05-07 | Lipocine, Inc. | Compositions and methods for improved delivery of ionizable hydrophobic therapeutic agents |
US6632451B2 (en) | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
US6387894B1 (en) | 1999-06-11 | 2002-05-14 | Pfizer Inc. | Use of CRF antagonists and renin-angiotensin system inhibitors |
KR20020013936A (en) | 1999-06-25 | 2002-02-21 | 추후제출 | Substituted phenoxyacetic acids |
US6309663B1 (en) | 1999-08-17 | 2001-10-30 | Lipocine Inc. | Triglyceride-free compositions and methods for enhanced absorption of hydrophilic therapeutic agents |
US20030235595A1 (en) | 1999-06-30 | 2003-12-25 | Feng-Jing Chen | Oil-containing, orally administrable pharmaceutical composition for improved delivery of a therapeutic agent |
SE9902597D0 (en) | 1999-07-06 | 1999-07-06 | Astra Ab | New use |
US6677356B1 (en) | 1999-08-24 | 2004-01-13 | Medicure International Inc. | Treatment of cardiovascular and related pathologies |
US6432989B1 (en) | 1999-08-27 | 2002-08-13 | Pfizer Inc | Use of CRF antagonists to treat circadian rhythm disorders |
US20030225124A1 (en) | 1999-08-31 | 2003-12-04 | Spiridon Spireas | Stable formulations of ACE inhibitors, and methods for preparation thereof |
US6555551B1 (en) | 1999-08-31 | 2003-04-29 | Mutual Pharmaceutical Co., Inc. | Stable formulations of ACE inhibitors, and methods for preparation thereof |
WO2001017528A1 (en) | 1999-09-08 | 2001-03-15 | Nitromed, Inc. | Methods of treating and preventing congestive heart failure with hydralazine compounds and isosorbide dinitrate or isosorbide mononitrate |
US6414002B1 (en) | 1999-09-22 | 2002-07-02 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
US6515117B2 (en) | 1999-10-12 | 2003-02-04 | Bristol-Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
PH12000002657B1 (en) | 1999-10-12 | 2006-02-21 | Bristol Myers Squibb Co | C-aryl glucoside SGLT2 inhibitors |
US6720001B2 (en) | 1999-10-18 | 2004-04-13 | Lipocine, Inc. | Emulsion compositions for polyfunctional active ingredients |
AU8026200A (en) | 1999-10-19 | 2001-04-30 | Board Of Regents, The University Of Texas System | Treatment of heart disease with cox-2 inhibitors |
EP1093814A1 (en) | 1999-10-22 | 2001-04-25 | Boehringer Ingelheim Pharma KG | Use of dipyridamole or mopidamol in the manufacture of a medicament for the treatment and prevention of fibrin-dependent microcirculation disorders |
US6264981B1 (en) | 1999-10-27 | 2001-07-24 | Anesta Corporation | Oral transmucosal drug dosage using solid solution |
US7537785B2 (en) | 1999-10-29 | 2009-05-26 | Nitromed, Inc. | Composition for treating vascular diseases characterized by nitric oxide insufficiency |
WO2001035961A1 (en) | 1999-10-29 | 2001-05-25 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US7235237B2 (en) | 1999-10-29 | 2007-06-26 | Nitromed, Inc. | Methods of treating vascular diseases characterized by nitric oxide insufficiency |
US20030113330A1 (en) | 1999-11-08 | 2003-06-19 | Uhal Bruce D. | Methods for treating pulmonary fibrosis |
US20030180352A1 (en) | 1999-11-23 | 2003-09-25 | Patel Mahesh V. | Solid carriers for improved delivery of active ingredients in pharmaceutical compositions |
IL133196A0 (en) | 1999-11-29 | 2001-03-19 | Yissum Res Dev Co | Gastroretentive controlled release pharmaceutical dosage forms |
MY125533A (en) | 1999-12-06 | 2006-08-30 | Bristol Myers Squibb Co | Heterocyclic dihydropyrimidine compounds |
US20020068740A1 (en) | 1999-12-07 | 2002-06-06 | Mylari Banavara L. | Combination of aldose reductase inhibitors and antihypertensive agents for the treatment of diabetic complications |
FR2803525B1 (en) | 2000-01-06 | 2002-05-03 | Sod Conseils Rech Applic | SIGNAL TRANSDUCTION INHIBITOR OF HETEROTRIMERIC PROTEINS ASSOCIATED WITH AN ANTI-HYPERTENSION AGENT IN THE TREATMENT OF ARTERIAL HYPERTENSION |
CA2396596A1 (en) | 2000-01-28 | 2001-08-02 | Bristol-Myers Squibb Company | Tetrahydropyrimidone inhibitors of fatty acid binding protein and method |
US6570013B2 (en) | 2000-02-16 | 2003-05-27 | Pfizer Inc | Salts of zopolrestat |
PL356422A1 (en) | 2000-02-18 | 2004-06-28 | Takeda Chemical Industries, Ltd. | Tnf-alpha inhibitors |
US20030068374A1 (en) | 2000-02-21 | 2003-04-10 | Shigeru Kamei | Sustained release preparations of physiologically active compound hardly soluble in water and production process and use of the same |
US20030152636A1 (en) | 2000-02-23 | 2003-08-14 | Nanopharm Ag | Method of treating cancer |
DE60133323T2 (en) | 2000-02-29 | 2009-03-05 | Medicure International Inc. | Cardioprotective phosphonates |
AU2001238718A1 (en) | 2000-03-02 | 2001-09-12 | The Institutes For Pharmaceutical Discovery, Llc | Compositions containing a substituted indolealkanoic acid and an angiotensin converting enzyme inhibitor |
CZ20023121A3 (en) | 2000-03-17 | 2003-05-14 | Ajinomoto Co., Inc. | Pharmaceutical preparations intended for treating diabetic complications and neuropathy and use of such preparations |
US6436684B1 (en) | 2000-03-27 | 2002-08-20 | Applera Corporation | Isolated human drug-metabolizing proteins, nucleic acid molecules encoding human drug-metabolizing proteins, and uses thereof |
DE10014588A1 (en) | 2000-03-27 | 2001-10-04 | Basf Ag | Sustained-release oral dosage form that floats in gastric fluid includes a blend of polyvinyl acetate and polyvinylpyrrolidone |
EP1277730A4 (en) | 2000-03-28 | 2005-03-16 | Neovascularization inhibitors | |
CA2403555A1 (en) | 2000-03-28 | 2001-10-04 | Queen's University At Kingston | Methods for effecting neuroprotection |
DE10015479A1 (en) | 2000-03-29 | 2001-10-11 | Basf Ag | Solid oral dosage forms with delayed release of active ingredient and high mechanical stability |
CA2405496A1 (en) | 2000-04-03 | 2001-10-11 | Richard A. Reeves | Vasopeptidase inhibitors to treat isolated systolic hypertension |
GB0008269D0 (en) | 2000-04-05 | 2000-05-24 | Astrazeneca Ab | Combination chemotherapy |
GB2361185A (en) | 2000-04-10 | 2001-10-17 | Nicholas J Wald | Pharmaceutical formulation for the prevention of cardiovascular disease |
AU5340101A (en) | 2000-04-11 | 2001-10-23 | Atherogenics Inc | Compounds and methods to increase plasma hdl cholesterol levels and improve hdl functionality |
WO2003030868A1 (en) | 2001-10-09 | 2003-04-17 | Bristol-Myers Squibb Company | Flashmelt oral dosage formulation |
US20030083342A1 (en) | 2002-08-27 | 2003-05-01 | Steele Ronald Edward | Combination of organic compounds |
US20040023840A1 (en) | 2000-04-12 | 2004-02-05 | Marc De Gasparo | Combination of organic compounds |
CA2311734C (en) | 2000-04-12 | 2011-03-08 | Bristol-Myers Squibb Company | Flash-melt oral dosage formulation |
AR030557A1 (en) | 2000-04-14 | 2003-08-27 | Jagotec Ag | A TABLET IN MULTI-MAP OF CONTROLLED RELEASE AND TREATMENT METHOD |
ATE389455T1 (en) | 2000-05-10 | 2008-04-15 | Jagotec Ag | GRINDING BY MEANS OF GRINDING MEDIUM |
JP2004507456A (en) | 2000-05-11 | 2004-03-11 | ブリストル−マイヤーズ スクイブ カンパニー | Tetrahydroisoquinoline analogs useful as growth hormone secretagogues |
AU2001256733A1 (en) | 2000-05-16 | 2001-11-26 | Takeda Chemical Industries Ltd. | Melanin-concentrating hormone antagonist |
US6911468B2 (en) | 2000-05-22 | 2005-06-28 | Takeda Chemical Industries, Ltd. | Tyrosine phosphatase inhibitors |
WO2001089519A1 (en) | 2000-05-22 | 2001-11-29 | Nitromed, Inc. | Thromboxane inhibitors, compositions and methods of use related applications |
US20020049155A1 (en) | 2000-05-31 | 2002-04-25 | Hogenkamp Henricus P.C. | Cobalamin compounds useful as cardiovascular agents and as imaging agents |
US20030212124A1 (en) | 2001-05-30 | 2003-11-13 | Kevorkian Robert C. | Use of ace inhibitors for treatment of patients suffering from behavioral disorders |
US20020044962A1 (en) | 2000-06-06 | 2002-04-18 | Cherukuri S. Rao | Encapsulation products for controlled or extended release |
US7678387B2 (en) | 2000-06-06 | 2010-03-16 | Capricorn Pharma, Inc. | Drug delivery systems |
US6544981B2 (en) | 2000-06-09 | 2003-04-08 | Bristol-Myers Squibb Company | Lactam inhibitors of factor Xa and method |
US20020013334A1 (en) | 2000-06-15 | 2002-01-31 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
US6627636B2 (en) | 2000-06-15 | 2003-09-30 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
US20020028826A1 (en) | 2000-06-15 | 2002-03-07 | Robl Jeffrey A. | HMG-CoA reductase inhibitors and method |
US6620821B2 (en) | 2000-06-15 | 2003-09-16 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors and method |
US6670355B2 (en) | 2000-06-16 | 2003-12-30 | Wyeth | Method of treating cardiovascular disease |
US20020013335A1 (en) | 2000-06-16 | 2002-01-31 | American Home Products Corporation | Method of treating cardiovascular disease |
DE10029201A1 (en) | 2000-06-19 | 2001-12-20 | Basf Ag | Retarded release oral dosage form, obtained by granulating mixture containing active agent and polyvinyl acetate-polyvinyl pyrrolidone mixture below the melting temperature |
US6656966B2 (en) | 2000-06-22 | 2003-12-02 | Nitromed, Inc. | Nitrosated and nitrosylated taxanes, compositions and methods of use |
KR100798566B1 (en) | 2000-06-27 | 2008-01-28 | 안제스에무지 가부시키가이샤 | Medicinal compositions for angiogenic therapy |
US7799794B2 (en) | 2000-06-28 | 2010-09-21 | Merck Sharp & Dohme Corp. | Treatment for cardiovascular disease |
US20030114420A1 (en) | 2000-06-28 | 2003-06-19 | Salvati Mark E. | Fused cyclic modulators of nuclear hormone receptor function |
WO2002002081A1 (en) | 2000-07-05 | 2002-01-10 | Capricorn Pharma, Inc. | Rapid-melt semi-solid compositions, methods of making same and methods of using same |
US6375982B1 (en) | 2000-07-05 | 2002-04-23 | Capricorn Pharma, Inc. | Rapid-melt semi-solid compositions, methods of making same and method of using same |
DE60128912T9 (en) | 2000-07-07 | 2008-06-26 | Medicure International Inc. | PYRIDOXIN AND PYRIDOXAL ANALOGUES AS CARDIOVASCULAR THERAPEUTICS |
KR100866820B1 (en) | 2000-07-13 | 2008-11-04 | 다케다 야쿠힌 고교 가부시키가이샤 | Lipid-rich plaque inhibitors |
US6610716B2 (en) | 2000-07-13 | 2003-08-26 | Alteon Incorporated | Cyanomethyl substituted thiazoliums and imidazoliums and treatments of disorders associated with protein aging |
US20030176426A1 (en) | 2000-07-13 | 2003-09-18 | Alteon, Inc. | Method for treating fibrotic diseases or other indications with imidazolium agents |
AU2001280804A1 (en) | 2000-07-27 | 2002-02-13 | Eileen R. Blasi | Aldosterone blocker therapy to prevent or treat inflammation-related disorders |
US6511973B2 (en) | 2000-08-02 | 2003-01-28 | Bristol-Myers Squibb Co. | Lactam inhibitors of FXa and method |
GB0020691D0 (en) | 2000-08-22 | 2000-10-11 | Boehringer Ingelheim Pharma | Pharmaceutical combination |
US6664230B1 (en) | 2000-08-24 | 2003-12-16 | The Regents Of The University Of California | Orally administered peptides to ameliorate atherosclerosis |
US7166578B2 (en) | 2000-08-24 | 2007-01-23 | The Regents Of The University Of California | Orally administered peptides synergize statin activity |
AU2001280135A1 (en) | 2000-08-25 | 2002-03-04 | Takeda Chemical Industries Ltd. | Fibrinogen lowering agents |
US6521747B2 (en) | 2000-08-28 | 2003-02-18 | Genaissance Pharmaceuticals, Inc. | Haplotypes of the AGTR1 gene |
CA2420844A1 (en) | 2000-08-30 | 2003-02-28 | Sankyo Company, Limited | Medicinal compositions for preventing or treating heart failure |
DE60137943D1 (en) | 2000-08-31 | 2009-04-23 | Jagotec Ag | GROUND PARTICLES |
US6576644B2 (en) | 2000-09-06 | 2003-06-10 | Bristol-Myers Squibb Co. | Quinoline inhibitors of cGMP phosphodiesterase |
US6632180B1 (en) | 2000-09-07 | 2003-10-14 | John H. Laragh | Method for evaluating and treating hypertension |
US6595926B1 (en) | 2000-09-07 | 2003-07-22 | John H. Laragh | Method for evaluating and treating hypertension |
US6821978B2 (en) | 2000-09-19 | 2004-11-23 | Schering Corporation | Xanthine phosphodiesterase V inhibitors |
US20020048599A1 (en) | 2000-10-20 | 2002-04-25 | Thomas H. Mueller | Method for increasing tissue perfusion by co-administration of an agent that increases cGMP synthesis and an agent that inhibits cGMP degradation |
CA2425280A1 (en) | 2000-10-26 | 2002-05-02 | Pfizer Products Inc. | Pyrimidine-2,4,6-trione metalloproteinase inhibitors |
US6841671B2 (en) | 2000-10-26 | 2005-01-11 | Pfizer Inc. | Spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
CA2428817C (en) | 2000-11-17 | 2010-06-01 | Takeda Chemical Industries, Ltd. | Copolyvidone-containing preparation |
US6670380B2 (en) | 2000-11-20 | 2003-12-30 | Bristol-Myers Squibb Co. | Pyridone inhibitors of fatty acid binding protein and method |
JP4107831B2 (en) | 2000-11-21 | 2008-06-25 | 第一三共株式会社 | Pharmaceutical composition |
CA2430341A1 (en) | 2000-11-28 | 2002-06-06 | The University Of Chicago | Genetically engineered herpes virus for the treatment of cardiovascular disease |
US6673802B2 (en) | 2000-12-01 | 2004-01-06 | Osi Pharmaceuticals, Inc. | Compounds specific to adenosine A3 receptor and uses thereof |
WO2002043807A2 (en) | 2000-12-01 | 2002-06-06 | Novartis Ag | Combinations of an angiotensin receptor antagonist and an anti-hypertensive drug or a statin, for the treatment of sexual dysfunction |
CA2430934C (en) | 2000-12-01 | 2011-06-21 | Takeda Chemical Industries, Ltd. | A method of producing sustained-release preparations of a bioactive substance using high-pressure gas |
US20020137755A1 (en) | 2000-12-04 | 2002-09-26 | Bilodeau Mark T. | Tyrosine kinase inhibitors |
WO2002049630A2 (en) | 2000-12-21 | 2002-06-27 | Bristol-Myers Squibb Company | Method for preventing or treating pain by administering an endothelin antagonist |
DE60138768D1 (en) | 2000-12-28 | 2009-07-02 | Kissei Pharmaceutical | Glucopyranosylpyrrazole derivatives and their use in medicines |
WO2002053161A1 (en) | 2000-12-29 | 2002-07-11 | Alteon, Inc. | Method for treating fibrotic diseases or other indications |
CA2433425A1 (en) | 2000-12-29 | 2002-09-06 | Alteon, Inc. | Method for treating fibrotic diseases or other indications iiic |
WO2002053101A2 (en) | 2000-12-29 | 2002-07-11 | Alteon, Inc. | Method for treating fibrotic diseases or other indications |
ITMI20010129A1 (en) | 2001-01-25 | 2002-07-25 | Pharmacia & Upjohn Spa | ESSENTIAL FATTY ACIDS IN THE THERAPY OF HEART INSUFFICIENCY AND HEART FAILURE |
ATE348649T1 (en) | 2001-01-26 | 2007-01-15 | Schering Corp | COMBINATIONS OF A STEROL ABSORPTION INHIBITOR AND A PPAR ACTIVATOR FOR THE TREATMENT OF CARDIOVASCULAR INDICATIONS |
US20030053981A1 (en) | 2001-01-26 | 2003-03-20 | Schering Corporation | Combinations of bile acid sequestrant(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
SK9502003A3 (en) | 2001-01-26 | 2003-12-02 | Schering Corp | Combinations of sterol absorption inhibitor(s) with blood modifier(s) for treating vascular conditions |
EP1671650A1 (en) | 2001-01-26 | 2006-06-21 | Schering Corporation | Combinations of nicotinic acid and derivatives thereof and sterol absorption inhibitor(s) and treatments for vascular indications |
MXPA03006724A (en) | 2001-01-26 | 2003-10-24 | Schering Corp | Combinations of sterol absorption inhibitor(s) with cardiovascular agent(s) for the treatment of vascular conditions. |
EP1358178A2 (en) | 2001-01-30 | 2003-11-05 | Bristol-Myers Squibb Company | Sulfonamide lactam inhibitors of factor xa |
TWI255817B (en) | 2001-02-14 | 2006-06-01 | Kissei Pharmaceutical | Glucopyranosyloxybenzylbenzene derivatives and medicinal use thereof |
FI114483B (en) | 2001-02-20 | 2004-10-29 | Jurilab Ltd Oy | Procedure for detecting a risk of elevated blood pressure and its uses |
US7087579B2 (en) | 2001-02-26 | 2006-08-08 | Kissei Pharmaceutical Co., Ltd. | Glucopyranosyloxypyrazole derivatives and medicinal use thereof |
JP4147111B2 (en) | 2001-02-27 | 2008-09-10 | キッセイ薬品工業株式会社 | Glucopyranosyloxypyrazole derivative and its pharmaceutical use |
DE60204611T2 (en) | 2001-02-28 | 2006-05-11 | Pfizer Products Inc., Groton | Sulfonyl-pyridazinone derivatives for use as aldose reductase inhibitors |
US20030119010A1 (en) | 2001-03-01 | 2003-06-26 | University Of Queensland | Polynucleotides and polypeptides linked to a disease or condition |
EP1370211A4 (en) | 2001-03-02 | 2005-02-09 | Bristol Myers Squibb Co | Co-administration of melanocortin receptor agonist and phosphodiesterase inhibitor for treatment of cyclic-amp associated disorders |
JP2004532838A (en) | 2001-03-02 | 2004-10-28 | ブリストル−マイヤーズ スクイブ カンパニー | Compounds useful as melanocortin receptor modulators and pharmaceutical compositions containing them |
US6936590B2 (en) | 2001-03-13 | 2005-08-30 | Bristol Myers Squibb Company | C-aryl glucoside SGLT2 inhibitors and method |
US6642244B2 (en) | 2001-03-16 | 2003-11-04 | Bristol-Myers Squibb Co. | Pyrazolopyridopyrimidine inhibitors of cGMP phosphodiesterase |
EP1247809A3 (en) | 2001-03-30 | 2003-12-17 | Pfizer Products Inc. | Triazine compounds useful as sorbitol dehydrogenase inhibitors |
PL365294A1 (en) | 2001-03-30 | 2004-12-27 | Pfizer Products Inc. | Pyridazinone aldose reductase inhibitors |
ES2258141T3 (en) | 2001-04-11 | 2006-08-16 | Bristol-Myers Squibb Company | C-ARILO GLUCOSIDE AMINO ACIDS COMPLEX FOR DIABETES TREATMENT AND PROCEDURE. |
US20030004199A1 (en) | 2001-04-12 | 2003-01-02 | Isabelle Ounis | Method for preventing or treating pulmonary inflammation by administering an endothelin antagonist |
WO2002083074A2 (en) | 2001-04-13 | 2002-10-24 | Children's Hospital Medical Center | Methods for the treatment of hepatic disorders |
WO2002087503A2 (en) | 2001-04-26 | 2002-11-07 | Vanderbilt University | Compositions and methods for treating colorectal polyps and cancer |
EP1406608B1 (en) | 2001-05-02 | 2009-07-29 | Nitromed, Inc. | Nitrosated and nitrosylated nebivolol and its metabolites, compositions and methods of use |
US20020168393A1 (en) | 2001-05-08 | 2002-11-14 | Ryota Sugimoto | Implantable medical material and implantable medical device |
US20030073705A1 (en) | 2001-05-14 | 2003-04-17 | Shahnaz Shahinfar | Method of treatment |
US6777443B2 (en) | 2001-05-15 | 2004-08-17 | Novartis Ag | Dipeptide derivatives |
US20030078190A1 (en) | 2001-05-25 | 2003-04-24 | Weinberg Marc S. | Methods for tissue protection using highly effective inhibition of the renin-angiotensin system |
US20030060451A1 (en) | 2001-05-29 | 2003-03-27 | Rajneesh Taneja | Enhancement of oral bioavailability of non-emulsified formulations of prodrug esters with lecithin |
EP1406611A2 (en) | 2001-05-30 | 2004-04-14 | Alteon, Inc. | Method for treating fibrotic diseases or other indications |
US20030092736A1 (en) | 2001-05-30 | 2003-05-15 | Cheng Peter T. | Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method |
EP1404339A4 (en) | 2001-05-30 | 2004-08-25 | Alteon Inc | Method for treating fibrotic diseases or other indications vi |
US6967212B2 (en) | 2001-05-30 | 2005-11-22 | Bristol-Myers Squibb Company | Substituted azole acid derivatives useful as antidiabetic and antiobesity agents and method |
US7105556B2 (en) | 2001-05-30 | 2006-09-12 | Bristol-Myers Squibb Company | Conformationally constrained analogs useful as antidiabetic and antiobesity agents and method |
US20040156903A1 (en) | 2002-05-22 | 2004-08-12 | Abrams Andrew L.. | Metering and packaging of controlled release medication |
AU2002320038B2 (en) | 2001-06-18 | 2007-07-05 | Noven Pharmaceuticals, Inc. | Enhanced drug delivery in transdermal systems |
EP1414461A4 (en) | 2001-07-13 | 2005-10-26 | Bristol Myers Squibb Co | Pyrazinone inhibitors of fatty acid binding protein and method |
US20030158090A1 (en) | 2001-07-23 | 2003-08-21 | Ulrik Pedersen-Bjergaard | Renin-angiotensin system in diabetes mellitus |
EP1414795A4 (en) | 2001-07-31 | 2006-03-01 | Bristol Myers Squibb Co | Bicyclic modulators of androgen receptor function |
US6825208B2 (en) | 2001-08-20 | 2004-11-30 | Bristol-Myers Squibb Pharma Company | Tetrahydroquinoline derivatives as antithrombotic agents |
US20030124196A1 (en) | 2001-08-22 | 2003-07-03 | Susan Weinbach | Pulsatile release compositions and methods for enhanced intestinal drug absorption |
US20030083286A1 (en) | 2001-08-22 | 2003-05-01 | Ching-Leou Teng | Bioadhesive compositions and methods for enhanced intestinal drug absorption |
US6669955B2 (en) | 2001-08-28 | 2003-12-30 | Longwood Pharmaceutical Research, Inc. | Combination dosage form containing individual dosage units of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
DE60226615D1 (en) | 2001-08-28 | 2008-06-26 | Schering Corp | |
US6576256B2 (en) | 2001-08-28 | 2003-06-10 | The Brigham And Women's Hospital, Inc. | Treatment of patients at elevated cardiovascular risk with a combination of a cholesterol-lowering agent, an inhibitor of the renin-angiotensin system, and aspirin |
US20030087843A1 (en) | 2001-09-05 | 2003-05-08 | Washburn William N. | O-pyrazole glucoside SGLT2 inhibitors and method of use |
US20030050620A1 (en) | 2001-09-07 | 2003-03-13 | Isa Odidi | Combinatorial type controlled release drug delivery device |
CA2460117A1 (en) | 2001-09-11 | 2003-03-20 | The Regents Of The University Of Colorado, A Body Corporate | Expression profiling in the intact human heart |
US6638542B2 (en) | 2001-09-20 | 2003-10-28 | Nutricia N.V. | Reducing appetite in mammals by administering procyanidin and hydroxycitric acid |
US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
TWI331526B (en) | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
US20030119808A1 (en) | 2001-09-21 | 2003-06-26 | Schering Corporation | Methods of treating or preventing cardiovascular conditions while preventing or minimizing muscular degeneration side effects |
US7019010B2 (en) | 2001-09-27 | 2006-03-28 | Novertis Ag | Combinations |
US20030114469A1 (en) | 2001-09-27 | 2003-06-19 | Cohen David Saul | Combinations |
EP1298223A3 (en) | 2001-09-28 | 2003-07-23 | Pfizer Products Inc. | Methods related to the A-C repeat Z-sequence upstream from the aldose reductase gene |
US20030144198A1 (en) | 2001-09-28 | 2003-07-31 | Collins Douglas A. | Coadministration of transport protein with conjugated cobalamin to deliver agents |
US20030134810A1 (en) | 2001-10-09 | 2003-07-17 | Chris Springate | Methods and compositions comprising biocompatible materials useful for the administration of therapeutic agents |
US6592901B2 (en) | 2001-10-15 | 2003-07-15 | Hercules Incorporated | Highly compressible ethylcellulose for tableting |
CA2463908A1 (en) | 2001-10-18 | 2003-04-24 | Bristol-Myers Squibb Company | Human glucagon-like-peptide-1 mimics and their use in the treatment of diabetes and related conditions |
US20030152622A1 (en) | 2001-10-25 | 2003-08-14 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral diuretic |
US20030091630A1 (en) | 2001-10-25 | 2003-05-15 | Jenny Louie-Helm | Formulation of an erodible, gastric retentive oral dosage form using in vitro disintegration test data |
FR2831446B1 (en) | 2001-10-26 | 2004-03-05 | Sanofi Synthelabo | USE OF IRBESARTAN FOR THE PREPARATION OF MEDICINES USEFUL FOR THE PREVENTION OR TREATMENT OF PULMONARY HYPERTENSION |
AU2916902A (en) | 2001-10-29 | 2003-05-01 | Caritas St. Elizabeth's Medical Center Of Boston, Inc. | Glycogen synthase kinase function in endothelial cells |
US20030083614A1 (en) | 2001-10-30 | 2003-05-01 | Boehringer Ingelheim Pharma Kg | Controlled release endoprosthetic device |
US20030195205A1 (en) | 2001-11-02 | 2003-10-16 | Pfizer Inc. | PDE9 inhibitors for treating cardiovascular disorders |
WO2003040114A1 (en) | 2001-11-06 | 2003-05-15 | Bristol-Myers Squibb Company | Substituted acid derivatives useful as antidiabetic and antiobesity agents and method |
MXPA04004370A (en) | 2001-11-09 | 2004-08-11 | Schering Corp | Polycyclic guanine derivative phosphodiesterase v inhibitors. |
PE20030592A1 (en) | 2001-11-13 | 2003-07-07 | Schering Corp | NK1 ANTAGONIST |
US7361671B2 (en) | 2001-11-15 | 2008-04-22 | The Institute For Pharmaceutical Discovery, Inc. | Substituted heteroarylalkanoic acids |
WO2003043624A1 (en) | 2001-11-16 | 2003-05-30 | Bristol-Myers Squibb Company | Dual inhibitors of adipocyte fatty acid binding protein and keratinocyte fatty acid binding protein |
US20030206978A1 (en) | 2001-11-29 | 2003-11-06 | Bob Sherwood | Agglomerated particles including an active agent coprocessed with silicified microcrystalline cellulose |
TW200303309A (en) | 2001-12-04 | 2003-09-01 | Bristol Myers Squibb Co | Novel n-[4-(1h-imidazol-1-yl)-2-fluorophenyl]-3-trifluoromethyl)-1h-pyrazole-5-carboxamides as factor Xa inhibitors |
TW200302225A (en) | 2001-12-04 | 2003-08-01 | Bristol Myers Squibb Co | Substituted amino methyl factor Xa inhibitors |
WO2003048081A2 (en) | 2001-12-04 | 2003-06-12 | Bristol-Myers Squibb Company | Glycinamides as factor xa inhibitors |
US6831102B2 (en) | 2001-12-07 | 2004-12-14 | Bristol-Myers Squibb Company | Phenyl naphthol ligands for thyroid hormone receptor |
WO2003050110A1 (en) | 2001-12-10 | 2003-06-19 | Dr. Reddy's Laboratories Ltd. | Amorphous form of 2-n-butyl-3-( (2-(1h-tetrazol-5-yl) (1,1'-biphenyl)-4-yl) methyl) -1,3-diazaspiro (4,4') non-1-en-4-one |
PE20030762A1 (en) | 2001-12-18 | 2003-09-05 | Schering Corp | HETEROCYCLIC COMPOUNDS AS NK1 ANTAGONISTS |
ATE404544T1 (en) | 2001-12-19 | 2008-08-15 | Bristol Myers Squibb Co | CONDENSED HETEROCYCLIC COMPOUNDS AND ANALOGUES THEREOF; MODULATORS OF THE FUNCTION OF NUCLEAR HORMONE RECEPTORS |
EP1463510A2 (en) | 2001-12-20 | 2004-10-06 | Bristol-Myers Squibb Company | Administration of vasopeptidase inhibitors to reduce pulse pressure |
ES2294197T3 (en) | 2001-12-21 | 2008-04-01 | Supernus Pharmaceuticals, Inc. | FORMULATION OF ORAL CAPSULA WITH INCREASED PHYSICAL STABILITY. |
JP2005516968A (en) | 2001-12-29 | 2005-06-09 | ノボ ノルディスク アクティーゼルスカブ | Combination use of GLP-1 compound and late diabetic complication modulator |
EP1478648B1 (en) | 2002-02-01 | 2014-04-30 | ARIAD Pharmaceuticals, Inc. | Phosphorus-containing compounds and uses thereof |
WO2003065997A2 (en) | 2002-02-06 | 2003-08-14 | Vicor Technologies, Inc. | Anti-infarction molecules |
US20030221207A1 (en) | 2002-02-13 | 2003-11-27 | Pharmacia Corporation, Global Patent Department | Cardiac-specific 11beta hydroxysteroid dehydrogenase type 2 transgenic mice |
WO2003070278A1 (en) | 2002-02-19 | 2003-08-28 | Boehringer Ingelheim International Gmbh | Pharmaceutical combination of angiotensin ii antagonists and angiotensin i converting enzyme inhibitors |
US6951869B2 (en) | 2002-02-26 | 2005-10-04 | Schlesinger Stephen L | Use of leukotriene receptor antagonist for treatment of scarring |
ATE303178T1 (en) | 2002-02-27 | 2005-09-15 | Pfizer Prod Inc | ACC INHIBITORS |
US20040116510A1 (en) | 2002-03-05 | 2004-06-17 | Nichtberger Steven A. | Antihypertensive agent and cholesterol absorption inhibitor combination therapy |
US20030215526A1 (en) | 2002-03-08 | 2003-11-20 | Scott Stofik | Stable formulations of angiotensin converting enzyme (ACE) inhibitors |
CN101143221A (en) | 2002-03-15 | 2008-03-19 | 布赖汉姆妇女医院 | Central airway administration for systemic delivery of therapeutics |
JP2005531516A (en) | 2002-03-18 | 2005-10-20 | ファイザー・プロダクツ・インク | Method of treatment with selective EP4 receptor agonist |
US20030199424A1 (en) | 2002-03-20 | 2003-10-23 | Smith Maree Therese | Method of treatment and/or prophylaxis |
JP2005530719A (en) | 2002-03-29 | 2005-10-13 | ニューロジェン コーポレーション | Combination therapy for the treatment of conditions with pathogenic inflammatory components |
AU2003223491A1 (en) | 2002-04-05 | 2003-10-27 | Nitromed, Inc. | Nitric oxide donors, compositions and methods of use |
US6930085B2 (en) | 2002-04-05 | 2005-08-16 | The Regents Of The University Of California | G-type peptides to ameliorate atherosclerosis |
AU2003225102A1 (en) | 2002-04-23 | 2003-11-10 | Bristol-Myers Squibb Company | Modified-release vasopeptidase inhibitor formulation, combinations and method |
US20030203027A1 (en) | 2002-04-26 | 2003-10-30 | Ethicon, Inc. | Coating technique for deposition of drug substance on a substrate |
CA2480092A1 (en) | 2002-04-26 | 2003-11-06 | Pfizer Products Inc. | N-substituted-heteroaryloxy-aryl-spiro-pyrimidine-2,4,6-trione metalloproteinase inhibitors |
NI200300045A (en) | 2002-04-26 | 2005-07-08 | Pfizer Prod Inc | INHIBITORS OF TRIARILOXIARILOXIPIRIMIDIN-2,4,6-METALOPROTEINASE TRION. |
BR0309556A (en) | 2002-04-26 | 2005-02-09 | Pfizer Prod Inc | Pyrimidine-2,4,6-trione metalloproteinase inhibitors |
WO2003090755A1 (en) | 2002-04-26 | 2003-11-06 | Schering Aktiengesellschaft | Treatment of hypertension in women receiving hormone replacement therapy |
WO2003091259A1 (en) | 2002-04-26 | 2003-11-06 | Pfizer Products Inc. | Triaryl-oxy-aryl-spiro-pyrimidine-2, 4, 6-trione metalloproteinase inhibitors |
US20030203019A1 (en) | 2002-04-30 | 2003-10-30 | Cornelius John Mark | Coated conditioners for use in foods and pharmaceuticals |
TW200307667A (en) | 2002-05-06 | 2003-12-16 | Bristol Myers Squibb Co | Sulfonylaminovalerolactams and derivatives thereof as factor Xa inhibitors |
US7276514B2 (en) | 2002-05-15 | 2007-10-02 | Charitable Leadership Foundation - Medical Technology Acceleration Program | Pyrroloquinoline quinone drugs for treatment of cardiac injury and methods of use thereof |
AUPS236902A0 (en) | 2002-05-16 | 2002-06-13 | Northern Sydney Area Health Service | Composition and method for treating hypertension |
TW200407324A (en) | 2002-05-17 | 2004-05-16 | Bristol Myers Squibb Co | Bicyclic modulators of androgen receptor function |
US7375138B2 (en) | 2002-05-18 | 2008-05-20 | Sanofi-Aventis Deutschland Gmbh | Pentafluorosulfanylbenzoylguanidines, processes for their preparation, their use as medicaments or diagnostic aids, and medicaments comprising them |
US7057046B2 (en) | 2002-05-20 | 2006-06-06 | Bristol-Myers Squibb Company | Lactam glycogen phosphorylase inhibitors and method of use |
WO2003099206A2 (en) | 2002-05-21 | 2003-12-04 | Bristol-Myers Squibb Company | Indole compounds useful as impdh inhibitors |
US20030229007A1 (en) | 2002-05-30 | 2003-12-11 | Roberto Levi | Form of human renin and its use as a target in treatments for cardiac ischemia and arrhythmia |
ATE390425T1 (en) | 2002-05-31 | 2008-04-15 | Schering Corp | XANTHINE PHOSPHODIESTERASE V INHIBITOR POLYMORPHOS |
US20030233118A1 (en) | 2002-06-13 | 2003-12-18 | Hui John C. K. | Method for treating congestive heart failure using external counterpulsation |
US7157100B2 (en) | 2002-06-04 | 2007-01-02 | J.B. Chemicals & Pharmaceuticals Ltd. | Pharmaceutical composition for controlled drug delivery system |
US7049333B2 (en) | 2002-06-04 | 2006-05-23 | Sanofi-Aventis Deutschland Gmbh | Substituted thiophenes: compositions, processes of making, and uses in disease treatment and diagnosis |
US7763278B2 (en) | 2002-06-10 | 2010-07-27 | Elan Pharma International Ltd. | Nanoparticulate polycosanol formulations and novel polycosanol combinations |
US20040009972A1 (en) | 2002-06-17 | 2004-01-15 | Ding Charles Z. | Benzodiazepine inhibitors of mitochondial F1F0 ATP hydrolase and methods of inhibiting F1F0 ATP hydrolase |
AU2003245614A1 (en) | 2002-06-19 | 2004-01-06 | Bristol-Myers Squibb Company | Ureido-substituted aniline compounds useful as serine protease inhibitors |
EP1382334A1 (en) | 2002-07-11 | 2004-01-21 | Université de Picardie Jules Verne | Use of angiotensin II AT1-receptor blockers (ARB), alone or combined with thiazide or angiotensin II for the treatment of stroke |
US20040138306A1 (en) | 2002-07-25 | 2004-07-15 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Use of a specific cyclic amine derivative or the pharmaceutically acceptable salts thereof for the treatment or prevention of heart failure |
US7985422B2 (en) | 2002-08-05 | 2011-07-26 | Torrent Pharmaceuticals Limited | Dosage form |
AU2003279842A1 (en) | 2002-10-04 | 2004-05-04 | Microchips, Inc. | Medical device for controlled drug delivery and cardiac monitoring and/or stimulation |
US20040106954A1 (en) | 2002-11-15 | 2004-06-03 | Whitehurst Todd K. | Treatment of congestive heart failure |
US7268157B2 (en) | 2002-11-26 | 2007-09-11 | Shenzhen Chipscreen Biosciences, Ltd. | Substituted arylalcanoic acid derivatives as PPAR pan agonists with potent antihyperglycemic and antihyperlipidemic activity |
-
2005
- 2005-06-02 US US11/143,556 patent/US8226977B2/en not_active Expired - Fee Related
- 2005-06-02 CA CA2568640A patent/CA2568640C/en not_active Expired - Fee Related
- 2005-06-02 EP EP05775601A patent/EP1750862B1/en active Active
- 2005-06-02 PL PL05775601T patent/PL1750862T3/en unknown
- 2005-06-02 DE DE602005025755T patent/DE602005025755D1/en active Active
- 2005-06-02 WO PCT/IB2005/002689 patent/WO2005118166A2/en not_active Application Discontinuation
- 2005-06-02 ES ES05775601T patent/ES2282062T1/en active Pending
- 2005-06-02 AT AT05775601T patent/ATE493973T1/en not_active IP Right Cessation
- 2005-06-02 AU AU2005249794A patent/AU2005249794A1/en not_active Abandoned
- 2005-06-02 JP JP2007514218A patent/JP4880591B2/en not_active Expired - Fee Related
-
2006
- 2006-11-30 IL IL179718A patent/IL179718A0/en unknown
-
2011
- 2011-08-19 JP JP2011179762A patent/JP2011252022A/en not_active Withdrawn
-
2012
- 2012-05-31 US US13/485,493 patent/US8414920B2/en not_active Expired - Fee Related
Non-Patent Citations (2)
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See also references of EP1750862A4 |
Cited By (7)
Publication number | Priority date | Publication date | Assignee | Title |
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DE102006006588A1 (en) * | 2006-02-13 | 2007-08-16 | Ratiopharm Gmbh | Fast-release irbesartan-containing pharmaceutical composition |
JP2009541239A (en) * | 2006-06-23 | 2009-11-26 | ノバルティス アクチエンゲゼルシャフト | Galenic formulation of aliskiren and hydrochlorothiazide |
US8618172B2 (en) | 2006-06-23 | 2013-12-31 | Novartis Ag | Galenical formulations of organic compounds |
JP2008156258A (en) * | 2006-12-22 | 2008-07-10 | Ss Pharmaceut Co Ltd | Oral solid composition having covered bitterness |
JP2010535212A (en) * | 2007-08-01 | 2010-11-18 | テバ ファーマシューティカル インダストリーズ リミティド | Improved candesartan formulation |
EP2065035A1 (en) * | 2007-11-28 | 2009-06-03 | Laboratorios Lesvi, S.L. | Pharmaceutical formulations containing irbesartan |
WO2011010316A1 (en) * | 2009-07-20 | 2011-01-27 | Hetero Research Foundation | Pharmaceutical compositions of irbesartan |
Also Published As
Publication number | Publication date |
---|---|
JP2011252022A (en) | 2011-12-15 |
US20050271720A1 (en) | 2005-12-08 |
DE602005025755D1 (en) | 2011-02-17 |
EP1750862B1 (en) | 2011-01-05 |
JP4880591B2 (en) | 2012-02-22 |
US8226977B2 (en) | 2012-07-24 |
ES2282062T1 (en) | 2007-10-16 |
EP1750862A2 (en) | 2007-02-14 |
CA2568640C (en) | 2011-08-09 |
US20120238555A1 (en) | 2012-09-20 |
PL1750862T3 (en) | 2011-06-30 |
CA2568640A1 (en) | 2005-12-15 |
EP1750862A4 (en) | 2008-06-11 |
JP2008501680A (en) | 2008-01-24 |
ATE493973T1 (en) | 2011-01-15 |
WO2005118166A3 (en) | 2006-07-27 |
IL179718A0 (en) | 2007-05-15 |
US8414920B2 (en) | 2013-04-09 |
AU2005249794A1 (en) | 2005-12-15 |
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