WO2006046155A3 - Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same - Google Patents

Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same Download PDF

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Publication number
WO2006046155A3
WO2006046155A3 PCT/IB2005/004007 IB2005004007W WO2006046155A3 WO 2006046155 A3 WO2006046155 A3 WO 2006046155A3 IB 2005004007 W IB2005004007 W IB 2005004007W WO 2006046155 A3 WO2006046155 A3 WO 2006046155A3
Authority
WO
WIPO (PCT)
Prior art keywords
particles
mammal
core
therapeutic
polyphosphazene
Prior art date
Application number
PCT/IB2005/004007
Other languages
French (fr)
Other versions
WO2006046155A2 (en
Inventor
Phillip Harder
Olaf Fritz
Ulf Fritz
Original Assignee
Polyzenix Gmbh
Phillip Harder
Olaf Fritz
Ulf Fritz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to CA2584122A priority Critical patent/CA2584122C/en
Priority to JP2007537420A priority patent/JP4885866B2/en
Priority to KR1020077011286A priority patent/KR101153785B1/en
Priority to AU2005298344A priority patent/AU2005298344B2/en
Application filed by Polyzenix Gmbh, Phillip Harder, Olaf Fritz, Ulf Fritz filed Critical Polyzenix Gmbh
Priority to DE602005027229T priority patent/DE602005027229D1/en
Priority to CN2005800366229A priority patent/CN101090710B/en
Priority to BRPI0518383-9A priority patent/BRPI0518383A2/en
Priority to EP05825096A priority patent/EP1804773B1/en
Priority to AT05825096T priority patent/ATE503465T1/en
Priority to TW094137269A priority patent/TW200626178A/en
Priority to MYPI20055024A priority patent/MY147841A/en
Publication of WO2006046155A2 publication Critical patent/WO2006046155A2/en
Publication of WO2006046155A3 publication Critical patent/WO2006046155A3/en
Priority to IL182650A priority patent/IL182650A/en
Priority to HK08105450.4A priority patent/HK1116058A1/en

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5031—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poly(lactide-co-glycolide)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0404—X-ray contrast preparations containing barium sulfate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/04—X-ray contrast preparations
    • A61K49/0409—Physical forms of mixtures of two different X-ray contrast-enhancing agents, containing at least one X-ray contrast-enhancing agent which is not a halogenated organic compound
    • A61K49/0414—Particles, beads, capsules or spheres
    • A61K49/0419—Microparticles, microbeads, microcapsules, microspheres, i.e. having a size or diameter higher or equal to 1 micrometer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1641—Organic macromolecular compounds obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, poloxamers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1682—Processes
    • A61K9/1694—Processes resulting in granules or microspheres of the matrix type containing more than 5% of excipient
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5089—Processes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

Abstract

Particles are provided for use in therapeutic and/or diagnostic procedures. The particles include poly[bis(trifluoroethoxy) phosphazene] and/or a derivatives thereof which may be present throughout the particles or within an outer coating of the particles. The particles can also include a core having a hydrogel formed from an acrylic-based polymer. Barium sulfate may also be provided to the core of the particles as a coating or absorbed within the core of the particles. The particles can be used to minimize blood flow to mammalian tissues by occluding at least a portion of a blood vessel of the mammal, or to deliver an active agent to a localized area within a body of a mammal by contacting a localized area with at least one of the particles. Further, the particles are useful in sustained release formulations including active agent(s) for oral administration, as tracer particles for injection into the bloodstream of a mammal or for use in enhanced ultrasound imaging. The particles may include agents for increasing density for achieving useful buoyancy levels in suspension.
PCT/IB2005/004007 2004-10-25 2005-10-24 Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same WO2006046155A2 (en)

Priority Applications (13)

Application Number Priority Date Filing Date Title
CN2005800366229A CN101090710B (en) 2004-10-25 2005-10-24 Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
KR1020077011286A KR101153785B1 (en) 2004-10-25 2005-10-24 Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
AU2005298344A AU2005298344B2 (en) 2004-10-25 2005-10-24 Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
EP05825096A EP1804773B1 (en) 2004-10-25 2005-10-24 Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
DE602005027229T DE602005027229D1 (en) 2004-10-25 2005-10-24 LOADABLE POLYPHOSPHAZINE-HOLDING PARTICLES FOR THERAPEUTIC AND / OR DIAGNOSTIC APPLICATIONS AND MANUFACTURING AND USE METHOD THEREFOR
JP2007537420A JP4885866B2 (en) 2004-10-25 2005-10-24 Fillable polyphosphazene-containing particles for therapeutic and / or diagnostic applications and methods for their preparation and use
BRPI0518383-9A BRPI0518383A2 (en) 2004-10-25 2005-10-24 Chargeable polymeric particles for therapeutical and / or diagnostic applications and methods for preparing and using them
CA2584122A CA2584122C (en) 2004-10-25 2005-10-24 Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
AT05825096T ATE503465T1 (en) 2004-10-25 2005-10-24 LOADABLE POLYPHOSPHAZENE-CONTAINING PARTICLES FOR THERAPEUTIC AND/OR DIAGNOSTIC APPLICATIONS AND PRODUCTION AND USE METHODS THEREOF
TW094137269A TW200626178A (en) 2004-10-25 2005-10-25 Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
MYPI20055024A MY147841A (en) 2004-10-25 2005-10-25 Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
IL182650A IL182650A (en) 2004-10-25 2007-04-18 Loadable polymeric particles for therapeutic and/or diagnostic applications and methods of preparing and using the same
HK08105450.4A HK1116058A1 (en) 2004-10-25 2008-05-16 Loadable polymeric particles contaning polyphosphazene for therapeutic and/or diagnostic applications and methods of preparing and using the same

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US62172904P 2004-10-25 2004-10-25
US60/621,729 2004-10-25
US68430705P 2005-05-24 2005-05-24
US60/684,307 2005-05-24

Publications (2)

Publication Number Publication Date
WO2006046155A2 WO2006046155A2 (en) 2006-05-04
WO2006046155A3 true WO2006046155A3 (en) 2006-08-17

Family

ID=36228155

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/IB2005/004007 WO2006046155A2 (en) 2004-10-25 2005-10-24 Loadable polyphosphazene-comprising particles for therapeutic and/or diagnostic applications and methods of preparing and using the same

Country Status (14)

Country Link
US (4) US8318209B2 (en)
EP (1) EP1804773B1 (en)
JP (1) JP4885866B2 (en)
KR (1) KR101153785B1 (en)
AT (1) ATE503465T1 (en)
AU (1) AU2005298344B2 (en)
BR (1) BRPI0518383A2 (en)
CA (1) CA2584122C (en)
DE (1) DE602005027229D1 (en)
HK (1) HK1116058A1 (en)
IL (1) IL182650A (en)
MY (1) MY147841A (en)
TW (1) TW200626178A (en)
WO (1) WO2006046155A2 (en)

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