WO2006085075A3 - Colonic delivery of active agents - Google Patents
Colonic delivery of active agents Download PDFInfo
- Publication number
- WO2006085075A3 WO2006085075A3 PCT/GB2006/000448 GB2006000448W WO2006085075A3 WO 2006085075 A3 WO2006085075 A3 WO 2006085075A3 GB 2006000448 W GB2006000448 W GB 2006000448W WO 2006085075 A3 WO2006085075 A3 WO 2006085075A3
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- colon
- polyethyleneimine
- pectin
- beads
- amount
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1605—Excipients; Inactive ingredients
- A61K9/1629—Organic macromolecular compounds
- A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/465—Hydrolases (3) acting on ester bonds (3.1), e.g. lipases, ribonucleases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/47—Hydrolases (3) acting on glycosyl compounds (3.2), e.g. cellulases, lactases
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/1682—Processes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/10—Laxatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P39/00—General protective or antinoxious agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y305/00—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5)
- C12Y305/02—Hydrolases acting on carbon-nitrogen bonds, other than peptide bonds (3.5) in cyclic amides (3.5.2)
- C12Y305/02006—Beta-lactamase (3.5.2.6)
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/06—Gastro-intestinal diseases
- G01N2800/065—Bowel diseases, e.g. Crohn, ulcerative colitis, IBS
Abstract
Priority Applications (6)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP06709686A EP1845948A2 (en) | 2005-02-09 | 2006-02-09 | Colonic delivery of active agents |
AU2006211996A AU2006211996A1 (en) | 2005-02-09 | 2006-02-09 | Colonic delivery of active agents |
JP2007553714A JP2008529996A (en) | 2005-02-09 | 2006-02-09 | Intestinal delivery of active factors |
CA002595526A CA2595526A1 (en) | 2005-02-09 | 2006-02-09 | Colonic delivery of active agents |
BRPI0606943-6A BRPI0606943A2 (en) | 2005-02-09 | 2006-02-09 | delivery of active agents to the colon |
US11/628,832 US20080317666A1 (en) | 2005-02-09 | 2006-02-09 | Colonic Delivery of Active Agents |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US65134205P | 2005-02-09 | 2005-02-09 | |
US60/651,342 | 2005-02-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
WO2006085075A2 WO2006085075A2 (en) | 2006-08-17 |
WO2006085075A3 true WO2006085075A3 (en) | 2007-08-30 |
Family
ID=36793399
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/GB2006/000448 WO2006085075A2 (en) | 2005-02-09 | 2006-02-09 | Colonic delivery of active agents |
Country Status (8)
Country | Link |
---|---|
US (1) | US20080317666A1 (en) |
EP (1) | EP1845948A2 (en) |
JP (1) | JP2008529996A (en) |
CN (1) | CN101128187A (en) |
AU (1) | AU2006211996A1 (en) |
BR (1) | BRPI0606943A2 (en) |
CA (1) | CA2595526A1 (en) |
WO (1) | WO2006085075A2 (en) |
Families Citing this family (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7943328B1 (en) | 2006-03-03 | 2011-05-17 | Prometheus Laboratories Inc. | Method and system for assisting in diagnosing irritable bowel syndrome |
US20080085524A1 (en) | 2006-08-15 | 2008-04-10 | Prometheus Laboratories Inc. | Methods for diagnosing irritable bowel syndrome |
US8916182B2 (en) * | 2006-11-28 | 2014-12-23 | Universite De Namur | Composition comprising oligogalacturonans and polycationic saccharides |
WO2009040020A1 (en) * | 2007-09-11 | 2009-04-02 | Mondobiotech Laboratories Ag | Amylin as a therapeutic agent |
JP2010538994A (en) * | 2007-09-11 | 2010-12-16 | モンドバイオテック ラボラトリーズ アクチエンゲゼルシャフト | Use of BFGF1-24 and optionally (ARG8) vasopressin, for example to treat Streptococcus pneumoniae infection |
WO2009046874A1 (en) * | 2007-09-11 | 2009-04-16 | Mondobiotech Laboratories Ag | Therapeutic combination of trh-potentiating peptide and stresscopin |
US20100204145A1 (en) * | 2007-09-11 | 2010-08-12 | Dorian Bevec | Use of a peptide as a therapeutic agent |
ZA200903858B (en) * | 2008-06-19 | 2013-10-30 | Univ Of Witwatesrand Johannesburg | Pharmaceutical dosage form |
EP2393472B1 (en) | 2008-12-05 | 2019-06-05 | NanoMed Holdings Pty Ltd | Amphiphile prodrugs |
JP5504666B2 (en) * | 2009-03-25 | 2014-05-28 | ニプロ株式会社 | PHARMACEUTICAL COMPOSITION, PROCESS FOR PRODUCING THE SAME AND SUSTAINED RELEASE BASE |
US8852645B2 (en) | 2009-11-19 | 2014-10-07 | The Board Of Trustees Of The University Of Illinois | Self-assembled toroidal-spiral particles and manufacture and uses thereof |
CZ302789B6 (en) * | 2009-11-25 | 2011-11-09 | Zentiva, K. S. | Method of increasing solubility of pharmaceutically active compounds and targeted (controlled) transport thereof into intestine |
FR3027307B1 (en) * | 2014-10-16 | 2016-11-04 | Azurrx Sas | HYBRID PROTEIN MOLECULE CAPABLE OF INHIBITING AT LEAST ONE ANTIBIOTIC AND PHARMACEUTICAL COMPOSITION COMPRISING THE SAME |
CN108289894A (en) | 2015-09-29 | 2018-07-17 | 前药扩展私人有限公司 | New formulation and therapy |
US10940113B2 (en) * | 2017-02-24 | 2021-03-09 | Medical And Pharmaceutical Industry Technology And Development Center | Pharmaceutical composition for colon targeting, method for treating a colon-related disease using the same and preparation method thereof |
CA3106429A1 (en) * | 2018-08-05 | 2020-02-13 | Da Volterra | Method for improving anticancer agent efficacy |
CN113730374B (en) * | 2021-08-05 | 2023-03-24 | 中新国际联合研究院 | Sugar beet pectin-based oral sustained-release gel beads and preparation method thereof |
Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2843301A1 (en) * | 2002-08-09 | 2004-02-13 | Centre Nat Rech Scient | Orally administrable multiparticular formulation for intestinal delivery of active agents, comprises pectin granules in the form of a cationic salt containing the active agent, where the pectin is crosslinked with a cationic polymer |
WO2004016248A2 (en) * | 2002-08-09 | 2004-02-26 | Centre National De La Recherche Scientifique (Cnrs) | Galenic formulation for colon targeted delivery of active principles |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3959457A (en) * | 1970-06-05 | 1976-05-25 | Temple University | Microparticulate material and method of making such material |
FR2608456B1 (en) * | 1986-12-18 | 1993-06-18 | Mero Rousselot Satia | MICROCAPSULES BASED ON GELATIN AND POLYSACCHARIDES AND PROCESS FOR OBTAINING THEM |
DK0454044T3 (en) * | 1990-04-25 | 1996-04-22 | Hoechst Ag | Pharmacological preparation containing polyelectrolyte complexes in microparticle form and at least one active substance |
FI920206A0 (en) * | 1992-01-17 | 1992-01-17 | Pekka Untamo Heino | MEDICINSK ANVAENDNING, MEDICINSKT FOERFARANDE OCH PREPARAT. |
DE69726446T2 (en) * | 1996-10-09 | 2004-08-26 | Givaudan S.A. | METHOD FOR PRODUCING A PEARL-BASED FOOD ADDITIVE |
US6531152B1 (en) * | 1998-09-30 | 2003-03-11 | Dexcel Pharma Technologies Ltd. | Immediate release gastrointestinal drug delivery system |
IL130303A0 (en) * | 1999-06-03 | 2000-06-01 | M G Novobiotech Ltd | A bacterial strain processed plant extracts and probiotic compositions for human and veterinary use |
US6632451B2 (en) * | 1999-06-04 | 2003-10-14 | Dexcel Pharma Technologies Ltd. | Delayed total release two pulse gastrointestinal drug delivery system |
IL152127A0 (en) * | 2002-10-06 | 2003-05-29 | Bio Balance Corp | Probiotic compositions for the treatment of inflammatory bowel disease |
-
2006
- 2006-02-09 BR BRPI0606943-6A patent/BRPI0606943A2/en not_active Application Discontinuation
- 2006-02-09 EP EP06709686A patent/EP1845948A2/en not_active Withdrawn
- 2006-02-09 WO PCT/GB2006/000448 patent/WO2006085075A2/en active Application Filing
- 2006-02-09 JP JP2007553714A patent/JP2008529996A/en not_active Withdrawn
- 2006-02-09 AU AU2006211996A patent/AU2006211996A1/en not_active Abandoned
- 2006-02-09 US US11/628,832 patent/US20080317666A1/en not_active Abandoned
- 2006-02-09 CA CA002595526A patent/CA2595526A1/en not_active Abandoned
- 2006-02-09 CN CNA200680005835XA patent/CN101128187A/en active Pending
Patent Citations (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2843301A1 (en) * | 2002-08-09 | 2004-02-13 | Centre Nat Rech Scient | Orally administrable multiparticular formulation for intestinal delivery of active agents, comprises pectin granules in the form of a cationic salt containing the active agent, where the pectin is crosslinked with a cationic polymer |
WO2004016248A2 (en) * | 2002-08-09 | 2004-02-26 | Centre National De La Recherche Scientifique (Cnrs) | Galenic formulation for colon targeted delivery of active principles |
Also Published As
Publication number | Publication date |
---|---|
US20080317666A1 (en) | 2008-12-25 |
CA2595526A1 (en) | 2006-08-17 |
CN101128187A (en) | 2008-02-20 |
BRPI0606943A2 (en) | 2009-07-28 |
AU2006211996A1 (en) | 2006-08-17 |
WO2006085075A2 (en) | 2006-08-17 |
EP1845948A2 (en) | 2007-10-24 |
JP2008529996A (en) | 2008-08-07 |
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