WO2007021968A3 - Sustained release antihistamine and decongestant composition - Google Patents

Sustained release antihistamine and decongestant composition Download PDF

Info

Publication number
WO2007021968A3
WO2007021968A3 PCT/US2006/031434 US2006031434W WO2007021968A3 WO 2007021968 A3 WO2007021968 A3 WO 2007021968A3 US 2006031434 W US2006031434 W US 2006031434W WO 2007021968 A3 WO2007021968 A3 WO 2007021968A3
Authority
WO
WIPO (PCT)
Prior art keywords
decongestant
release
composition
sustained release
agent
Prior art date
Application number
PCT/US2006/031434
Other languages
French (fr)
Other versions
WO2007021968A2 (en
Inventor
Ronald L Perry
Jack T Irwin
Original Assignee
Perrigo L Co
Ronald L Perry
Jack T Irwin
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Perrigo L Co, Ronald L Perry, Jack T Irwin filed Critical Perrigo L Co
Priority to CA002618702A priority Critical patent/CA2618702A1/en
Publication of WO2007021968A2 publication Critical patent/WO2007021968A2/en
Publication of WO2007021968A3 publication Critical patent/WO2007021968A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/13—Amines
    • A61K31/135—Amines having aromatic rings, e.g. ketamine, nortriptyline
    • A61K31/137—Arylalkylamines, e.g. amphetamine, epinephrine, salbutamol, ephedrine or methadone

Abstract

A controlled-release, non-sedating antihistamine and decongestant composition which provides a 24-hour decongestant dissolution profile using standard ungranulated xanthan gum as the sole controlled-release agent and a process for preparing the same is provided. The pharmaceutical composition of the present invention typically includes: a compressed extended-release core comprising a pharmaceutically effective amount of decongestant, ungranulated xanthan gum, one or more binders, a flow agent, and a lubricant. An immediate-release coating composition is disposed on the core that typically includes a non-sedating antihistamine and at least one coating agent.
PCT/US2006/031434 2005-08-11 2006-08-11 Sustained release antihistamine and decongestant composition WO2007021968A2 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CA002618702A CA2618702A1 (en) 2005-08-11 2006-08-11 Sustained release antihistamine and decongestant composition

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US70726705P 2005-08-11 2005-08-11
US60/707,267 2005-08-11
US11/502,114 2006-08-10
US11/502,114 US20070036859A1 (en) 2005-08-11 2006-08-10 Sustained release antihistamine and decongestant composition

Publications (2)

Publication Number Publication Date
WO2007021968A2 WO2007021968A2 (en) 2007-02-22
WO2007021968A3 true WO2007021968A3 (en) 2007-11-22

Family

ID=37742808

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2006/031434 WO2007021968A2 (en) 2005-08-11 2006-08-11 Sustained release antihistamine and decongestant composition

Country Status (3)

Country Link
US (1) US20070036859A1 (en)
CA (1) CA2618702A1 (en)
WO (1) WO2007021968A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109966254B (en) * 2017-12-28 2021-06-01 广州医药研究总院有限公司 Compound pseudoephedrine hydrochloride sustained-release pellet and preparation method thereof

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20100143471A1 (en) * 2007-03-21 2010-06-10 Lupin Limited Novel reduced dose pharmaceutical compositions of fexofenadine and pseudoephedrine
CN101848706A (en) * 2007-06-01 2010-09-29 先灵-普劳健康护理产品公司 Pharmaceutical composition comprising a substrate and a coating containing an active ingredient and polyvinylalcohol
WO2010078543A1 (en) 2009-01-05 2010-07-08 Mcneil-Ppc, Inc. Tablet containing cetirizine pseudoephedrine, and naproxen containing a barrier layer
WO2010078541A1 (en) 2009-01-05 2010-07-08 Mcneil-Ppc, Inc. Tablet containing coated particles of cetirizine, pseudoephedrine, and/or naproxen
WO2010078542A1 (en) 2009-01-05 2010-07-08 Mcneil-Ppc, Inc. Three layer tablet containing cetirizine, pseudoephedrine, and naproxen
CN102210687B (en) * 2011-04-13 2013-05-15 赛乐医药科技(上海)有限公司 Compound methoxyphenamine sustained release preparation
US20180187263A1 (en) 2017-01-05 2018-07-05 Iowa State University Research Foundation, Inc. Kits for diagnostic detection and prevention of feedlot bovine respiratory disease
EP3655418A4 (en) 2017-06-22 2021-05-19 Triact Therapeutics, Inc. Methods of treating glioblastoma
US11628144B2 (en) 2017-09-29 2023-04-18 Triact Therapeutics, Inc. Iniparib formulations and uses thereof

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5314697A (en) * 1992-10-23 1994-05-24 Schering Corporation Stable extended release oral dosage composition comprising loratadine and pseudoephedrine
US5427799A (en) * 1992-03-25 1995-06-27 Valentine Enterprises, Inc. Sustained release composition and method utilizing xanthan gum and an active ingredient
US20050147673A1 (en) * 1996-06-10 2005-07-07 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible sustained release formulation containing microcrystalline cellulose

Family Cites Families (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NL132137C (en) * 1963-04-24
US3717647A (en) * 1971-04-09 1973-02-20 Schering Corp Alpha-nicotinoyl phenylacetonitriles
US4248858A (en) * 1979-08-09 1981-02-03 American Home Products Corporation Sustained release pharmaceutical compositions
US4832952A (en) * 1983-07-07 1989-05-23 American Home Products Corporation Pharmaceutical composition containing a liquid lubricant
HU194864B (en) * 1984-02-15 1988-03-28 Schering Corp Process for production of 8-chlor-6,11-dihydro-11-(4-piperidilidene)-5h-benzo (5,6)-cyclo-hepta (1,2-b) pyridine and its salts
GB8414221D0 (en) * 1984-06-04 1984-07-11 Sterwin Ag Unit dosage form
US4731447A (en) * 1985-05-13 1988-03-15 Schering Corporation Process for preparing piperidylidene dihydro-dibenzo(a,d)-cycloheptenes or aza-derivatives thereof
JPS62103012A (en) * 1985-10-23 1987-05-13 Eisai Co Ltd Multi-layered granule
US4753801A (en) * 1985-10-25 1988-06-28 Eli Lilly And Company Sustained release tablets
GB8601204D0 (en) * 1986-01-18 1986-02-19 Boots Co Plc Therapeutic agents
US4826853A (en) * 1986-10-31 1989-05-02 Schering Corporation 6,11-Dihydro-11-(N-substituted-4-piperidylidene)-5H-benzo(5,6)cyclohepta(1,2-B)pyridines and compositions and methods of use
US4990335A (en) * 1987-03-25 1991-02-05 E. I. Du Pont De Nemours And Company Use of vinyl alcohol homopolymer and copolymers for tableting active materials
US5219575A (en) * 1987-06-26 1993-06-15 Duphar International Research B.V. Compositions with controlled zero-order delivery rate and method of preparing these compositions
US5004613A (en) * 1987-07-27 1991-04-02 Mcneil-Ppc, Inc. Oral sustained release pharmaceutical formulation and process
US4915948A (en) * 1987-08-31 1990-04-10 Warner-Lambert Company Tablets having improved bioadhesion to mucous membranes
US4910023A (en) * 1988-06-09 1990-03-20 Warner-Lambert Company Drug in combination with flavor masking agent and method for making same
US5009897A (en) * 1988-06-24 1991-04-23 Abbott Laboratories Pharmaceutical granules and tablets made therefrom
JP2514078B2 (en) * 1988-08-22 1996-07-10 エスエス製薬株式会社 Compressed formulation
US5186930A (en) * 1988-11-14 1993-02-16 Schering Corporation Sustained release oral suspensions
US5202128A (en) * 1989-01-06 1993-04-13 F. H. Faulding & Co. Limited Sustained release pharmaceutical composition
US4990535A (en) * 1989-05-03 1991-02-05 Schering Corporation Pharmaceutical composition comprising loratadine, ibuprofen and pseudoephedrine
US5019396A (en) * 1989-05-12 1991-05-28 Alza Corporation Delivery dispenser for treating cardiac arrhythmias
EP0418596A3 (en) * 1989-09-21 1991-10-23 American Cyanamid Company Controlled release pharmaceutical compositions from spherical granules in tabletted oral dosage unit form
IT1237904B (en) * 1989-12-14 1993-06-18 Ubaldo Conte CONTROLLED SPEED RELEASE TABS OF ACTIVE SUBSTANCES
IT1241417B (en) * 1990-03-06 1994-01-14 Vectorpharma Int THERAPEUTIC COMPOSITIONS WITH CONTROLLED RELEASE OF DRUGS SUPPORTED ON CROSS-LINKED POLYMERS AND COATED WITH POLYMER FILM, AND THEIR PREPARATION PROCESS
IE61651B1 (en) * 1990-07-04 1994-11-16 Zambon Spa Programmed release oral solid pharmaceutical dosage form
JPH0794379B2 (en) * 1990-08-07 1995-10-11 ファイザー・インコーポレーテッド Methods of using interfacial polymerized membranes in release formulations
US5098715A (en) * 1990-12-20 1992-03-24 Burroughs Wellcome Co. Flavored film-coated tablet
DE4122217C2 (en) * 1991-07-04 1997-02-13 Merz & Co Gmbh & Co Process for the preparation of mechanically stable, well decomposing compressed products from small active substance-containing moldings
US5183829A (en) * 1991-09-27 1993-02-02 Applied Analytical Industries, Inc. Oral liquid compositions of non-steroidal anti-inflammatory drugs
US5407686A (en) * 1991-11-27 1995-04-18 Sidmak Laboratories, Inc. Sustained release composition for oral administration of active ingredient
ES2042421B1 (en) * 1992-05-22 1994-08-01 Uriach & Cia Sa J PROCEDURE FOR OBTAINING 8-CHLORINE-11- * 1 - * (5-METHYL-3-PIRIDIL) METHYL * -4-PIPERIDILIDEN * -6,11-DIHYDRO-5H-BENZO * 5,6 * CYCLOHEPTA * 1 , 2-B * PIRIDINE.
IT1255522B (en) * 1992-09-24 1995-11-09 Ubaldo Conte COMPRESSED FOR THERAPEUTIC USE SUITABLE FOR SELLING ONE OR MORE ACTIVE SUBSTANCES WITH DIFFERENT SPEEDS
FI101039B (en) * 1992-10-09 1998-04-15 Eeva Kristoffersson Method for preparing medicated pellets
US5411746A (en) * 1993-02-24 1995-05-02 Warner-Jenkinson Company, Inc. Dye compositions and methods for film coating tablets and the like
CA2128820A1 (en) * 1993-07-27 1995-01-28 Walter G. Gowan, Jr. Rapidly disintegrating pharmaceutical dosage form and process for preparation thereof
US5773025A (en) * 1993-09-09 1998-06-30 Edward Mendell Co., Inc. Sustained release heterodisperse hydrogel systems--amorphous drugs
KR950007873A (en) * 1993-09-20 1995-04-15 후꾸하라 요시하루 Biologics Sustained-Release Pharmaceutical Formulations
US6183778B1 (en) * 1993-09-21 2001-02-06 Jagotec Ag Pharmaceutical tablet capable of liberating one or more drugs at different release rates
US6210714B1 (en) * 1993-11-23 2001-04-03 Euro-Celtique S.A. Immediate release tablet cores of acetaminophen having sustained-release coating
US5500227A (en) * 1993-11-23 1996-03-19 Euro-Celtique, S.A. Immediate release tablet cores of insoluble drugs having sustained-release coating
US5419917A (en) * 1994-02-14 1995-05-30 Andrx Pharmaceuticals, Inc. Controlled release hydrogel formulation
ES2210321T3 (en) * 1994-12-19 2004-07-01 Daiichi Pharmaceutical Co., Ltd. GRANULAR PREPARATION OF PROLONGED RELEASE AND PRODUCTION PROCEDURE.
NZ280610A (en) * 1994-12-29 1997-08-22 Mcneil Ppc Inc Soft gelatin-like pharmaceutical carrier: gelled polyethylene glycol and dispersed active agent
IL116674A (en) * 1995-01-09 2003-05-29 Mendell Co Inc Edward Microcrystalline cellulose-based excipient having improved compressibility, pharmaceutical compositions containing the same and methods for the preparation of said excipient and of solid dosage form thereof
US5585115A (en) * 1995-01-09 1996-12-17 Edward H. Mendell Co., Inc. Pharmaceutical excipient having improved compressability
FR2729857B1 (en) * 1995-01-27 1997-04-04 Rhone Poulenc Chimie PHARMACEUTICAL COMPOSITIONS IN THE FORM OF SUSTAINED-RELEASE TABLETS BASED ON GRANULES OF HIGH MOLECULAR POLYSACCHARIDES
US5616621A (en) * 1995-01-30 1997-04-01 American Home Products Corporation Taste masking liquids
GB9507348D0 (en) * 1995-04-08 1995-05-31 Knoll Ag Therapeutic agents
US5900425A (en) * 1995-05-02 1999-05-04 Bayer Aktiengesellschaft Pharmaceutical preparations having controlled release of active compound and processes for their preparation
US5766623A (en) * 1996-03-25 1998-06-16 State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon State University Compactable self-sealing drug delivery agents
US5858409A (en) * 1996-04-17 1999-01-12 Fmc Corporation Hydrolyzed cellulose granulations for pharmaceuticals
US6024980A (en) * 1996-06-28 2000-02-15 Mcneil-Ppc, Inc. Multiphase soft gelatin dosage form
HRP970493A2 (en) * 1996-09-23 1998-08-31 Wienman E. Phlips Oral delayed immediate release medical formulation and method for preparing the same
US6361796B1 (en) * 1996-10-25 2002-03-26 Shire Laboratories, Inc. Soluble form osmotic dose delivery system
US6024981A (en) * 1997-04-16 2000-02-15 Cima Labs Inc. Rapidly dissolving robust dosage form
US6210710B1 (en) * 1997-04-28 2001-04-03 Hercules Incorporated Sustained release polymer blend for pharmaceutical applications
US5895663A (en) * 1997-07-31 1999-04-20 L. Perrigo Company Pseudoephedrine hydrochloride extended-release tablets
ES2234139T3 (en) * 1997-08-11 2005-06-16 Alza Corporation DOSAGE FORM OF AN ACTIVE PROLONGED RELEASE AGENT ADAPTED FOR GASTRIC RETENTION.
US5869479A (en) * 1997-08-14 1999-02-09 Schering Corporation Treatment of upper airway allergic responses
US5885616A (en) * 1997-08-18 1999-03-23 Impax Pharmaceuticals, Inc. Sustained release drug delivery system suitable for oral administration
US5904937A (en) * 1997-10-03 1999-05-18 Fmc Corporation Taste masked pharmaceutical compositions
US6335347B1 (en) * 1997-10-10 2002-01-01 Schering Corporation Ethyl 4-(8-chloro-5,6-dihydro-11 H-benzo[5,6]cyclohepta[1,2-b]pyridin-11-ylidene)-1-piperidene carboxylate polymorph
US6022554A (en) * 1997-12-15 2000-02-08 American Home Products Corporation Polymeric microporous film coated subcutaneous implant
US6365180B1 (en) * 1998-01-20 2002-04-02 Glenn A. Meyer Oral liquid compositions
IL128818A0 (en) * 1998-03-12 2000-01-31 Akzo Nobel Nv Making dosage units using low shear granulation
US6365185B1 (en) * 1998-03-26 2002-04-02 University Of Cincinnati Self-destructing, controlled release peroral drug delivery system
US6372254B1 (en) * 1998-04-02 2002-04-16 Impax Pharmaceuticals Inc. Press coated, pulsatile drug delivery system suitable for oral administration
US6531152B1 (en) * 1998-09-30 2003-03-11 Dexcel Pharma Technologies Ltd. Immediate release gastrointestinal drug delivery system
US6521254B2 (en) * 1998-12-07 2003-02-18 J-Med Pharmaceuticals, Inc. Single-dose antihistamine/decongestant formulations for treating rhinitis
US6051585A (en) * 1998-12-07 2000-04-18 Weinstein; Robert E. Single-dose antihistamine/decongestant formulations for treating rhinitis
US6248363B1 (en) * 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
SK287684B6 (en) * 1999-12-20 2011-06-06 Schering Corporation Sustained release solid oral pharmaceutical dosage composition
IN192160B (en) * 2000-07-17 2004-02-28 Ranbaxy Lab
US6358526B1 (en) * 2000-08-16 2002-03-19 Rexall Sundown Method of making tablets and tablet compositions produced therefrom
AU2002220248A1 (en) * 2000-11-06 2002-05-15 Andrx Pharmaceuticals, Inc. Once a day antihistamine and decongestant formulation
CA2440588C (en) * 2001-03-13 2010-02-09 Penwest Pharmaceuticals Co. Chronotherapeutic dosage forms
US6524617B1 (en) * 2001-07-25 2003-02-25 Isp Investments Inc. Synergistic filler composition
CN100478026C (en) * 2001-09-28 2009-04-15 纽特休迪克斯公司 Delivery system for biological component
US6933380B2 (en) * 2001-10-19 2005-08-23 Yung-Zip Chemical Ind. Co., Ltd. Excipients containing low residual solvent and method for producing the same
FR2832311B1 (en) * 2001-11-21 2004-04-16 Besins Int Belgique FILM-FORMING POWDER, COMPOSITIONS COMPRISING SAME, PREPARATION METHODS AND USES THEREOF

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5427799A (en) * 1992-03-25 1995-06-27 Valentine Enterprises, Inc. Sustained release composition and method utilizing xanthan gum and an active ingredient
US5314697A (en) * 1992-10-23 1994-05-24 Schering Corporation Stable extended release oral dosage composition comprising loratadine and pseudoephedrine
US20050147673A1 (en) * 1996-06-10 2005-07-07 J. Rettenmaier & Soehne Gmbh + Co. Kg Directly compressible sustained release formulation containing microcrystalline cellulose

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109966254B (en) * 2017-12-28 2021-06-01 广州医药研究总院有限公司 Compound pseudoephedrine hydrochloride sustained-release pellet and preparation method thereof

Also Published As

Publication number Publication date
WO2007021968A2 (en) 2007-02-22
US20070036859A1 (en) 2007-02-15
CA2618702A1 (en) 2007-02-22

Similar Documents

Publication Publication Date Title
WO2007021968A3 (en) Sustained release antihistamine and decongestant composition
MX2009000320A (en) Controlled-release formulations.
WO2006058059A3 (en) Composition comprising a sustained release coating or matrix and an nmda receptor antagonist, method for administration such nmda antagonist to a subject
WO2004108067A3 (en) Programmed drug delivery system
WO2008081891A1 (en) Orally disintegrating solid preparation
TWI347850B (en) Extended release tablet formulation containing pramipexole or a pharmaceutically acceptable salt thereof, method for manufacturing the same and use thereof
WO2006039499A3 (en) Method for improving the biovailability of orally delivered therapeutics
WO2005048979A3 (en) Pharmaceutical composition having casing with multiple micro tablets
WO2004000197A3 (en) Quick dissolve compositions and tablets based thereon
WO2003005968A3 (en) Dual release levodopa ethyl ester and decarboxylase inhibitor with immediate release levodopa
WO2005009381A3 (en) Immediate-release formulation of acid-labile pharmaceutical compositions
WO2010066749A3 (en) Ulipristal acetate tablets
CA2622805A1 (en) Compressed tablets comprising valsartan
MY151470A (en) Controlled release solid preparation
WO2005027843A3 (en) Chronotherapeutic dosage forms
MX2010003439A (en) Pharmaceutical combination of aliskiren and valsartan.
WO2004071374A3 (en) Once a day orally administered pharmaceutical compositions
MX2008002493A (en) Solid pharmaceutical composition comprising 1-(4-chloroanilino)-4 -(4-pyridylmethyl)phthalazine and a ph modifier.
WO2003057150A3 (en) A stable pharmaceutical formulation of paroxetine hydrochloride and a process for preparation thereof
WO2007143163A3 (en) Pharmaceutical compositions for sustained release of phenyephrine
WO2003059329A3 (en) Polytartrate composition
WO2008039351A3 (en) Method of manufacturing tablets containing pharmacologically active agents
WO2004062552A3 (en) Pharmaceutical composition containing a nsaid and a benzimidazole derivative
WO2003086362A3 (en) Method of stabilizing bupropion hydrochloride tablets
WO2007065625A3 (en) Pharmaceutical compositions of short-acting hypnotic agents in modified-release forms and the procedures to prepare the mentioned formulations

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application
ENP Entry into the national phase

Ref document number: 2618702

Country of ref document: CA

NENP Non-entry into the national phase

Ref country code: DE

122 Ep: pct application non-entry in european phase

Ref document number: 06801289

Country of ref document: EP

Kind code of ref document: A2