WO2007075963A3 - Systems and methods for the delivery of corticosteroids - Google Patents

Systems and methods for the delivery of corticosteroids Download PDF

Info

Publication number
WO2007075963A3
WO2007075963A3 PCT/US2006/048927 US2006048927W WO2007075963A3 WO 2007075963 A3 WO2007075963 A3 WO 2007075963A3 US 2006048927 W US2006048927 W US 2006048927W WO 2007075963 A3 WO2007075963 A3 WO 2007075963A3
Authority
WO
WIPO (PCT)
Prior art keywords
delivery
corticosteroid
systems
methods
inhalable
Prior art date
Application number
PCT/US2006/048927
Other languages
French (fr)
Other versions
WO2007075963A2 (en
Inventor
Malcolm R Hill
Original Assignee
Tika Laekemedel Ab
Malcolm R Hill
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Tika Laekemedel Ab, Malcolm R Hill filed Critical Tika Laekemedel Ab
Priority to JP2008547580A priority Critical patent/JP2009520828A/en
Priority to EP06845981A priority patent/EP1971346A2/en
Publication of WO2007075963A2 publication Critical patent/WO2007075963A2/en
Publication of WO2007075963A3 publication Critical patent/WO2007075963A3/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/56Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/57Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone
    • A61K31/573Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/70Carbohydrates; Sugars; Derivatives thereof
    • A61K31/715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
    • A61K31/716Glucans
    • A61K31/724Cyclodextrins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0078Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/08Antiallergic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/38Drugs for disorders of the endocrine system of the suprarenal hormones
    • A61P5/40Mineralocorticosteroids, e.g. aldosterone; Drugs increasing or potentiating the activity of mineralocorticosteroids

Abstract

The present invention relates to methods and systems for the delivery of a corticosteroid comprising (1) an inhalable aqueous mixture comprising a corticosteroid and a solubility enhancer and (2) an inhalable nebulizer, wherein the delivery of the aqueous mixture comprising the corticosteroid by the nebulizer results in an enhanced pharmacokinetic profile of the corticosteroid as compared to conventional inhalable therapies and/or increase lung deposition.
PCT/US2006/048927 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids WO2007075963A2 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
JP2008547580A JP2009520828A (en) 2005-12-20 2006-12-19 Systems and methods for delivering corticosteroids
EP06845981A EP1971346A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids

Applications Claiming Priority (8)

Application Number Priority Date Filing Date Title
US75233205P 2005-12-20 2005-12-20
US75273505P 2005-12-20 2005-12-20
US75276505P 2005-12-20 2005-12-20
US77399806P 2006-02-15 2006-02-15
US77399906P 2006-02-15 2006-02-15
US82009206P 2006-07-21 2006-07-21
US82009406P 2006-07-21 2006-07-21
US82009606P 2006-07-21 2006-07-21

Publications (2)

Publication Number Publication Date
WO2007075963A2 WO2007075963A2 (en) 2007-07-05
WO2007075963A3 true WO2007075963A3 (en) 2008-11-27

Family

ID=38218568

Family Applications (6)

Application Number Title Priority Date Filing Date
PCT/US2006/048628 WO2007075798A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048927 WO2007075963A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids
PCT/US2006/048631 WO2007075801A2 (en) 2005-12-20 2006-12-19 Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048630 WO2007075800A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids
PCT/US2006/048735 WO2007075859A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048629 WO2007075799A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile

Family Applications Before (1)

Application Number Title Priority Date Filing Date
PCT/US2006/048628 WO2007075798A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an increased lung deposition

Family Applications After (4)

Application Number Title Priority Date Filing Date
PCT/US2006/048631 WO2007075801A2 (en) 2005-12-20 2006-12-19 Method and system for the delivery of corticosteroids having an enhanced pharmacokinetic profile
PCT/US2006/048630 WO2007075800A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids
PCT/US2006/048735 WO2007075859A2 (en) 2005-12-20 2006-12-19 Systems and methods for the delivery of corticosteroids having an increased lung deposition
PCT/US2006/048629 WO2007075799A2 (en) 2005-12-20 2006-12-19 Methods and systems for the delivery of corticosteroids having an enhanced pharmacokinetic profile

Country Status (5)

Country Link
EP (6) EP1971345A2 (en)
JP (6) JP2009520821A (en)
BR (1) BRPI0620225A2 (en)
CA (2) CA2634413A1 (en)
WO (6) WO2007075798A2 (en)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20070020299A1 (en) 2003-12-31 2007-01-25 Pipkin James D Inhalant formulation containing sulfoalkyl ether cyclodextrin and corticosteroid
US7973929B2 (en) * 2007-11-16 2011-07-05 Particle Measuring Systems, Inc. System and method for calibration verification of an optical particle counter
JP2012505236A (en) * 2008-10-10 2012-03-01 シェーリング コーポレイション Corticosteroid composition and method of treatment thereof
EP3094355A1 (en) * 2014-01-17 2016-11-23 Nephron Pharmaceuticals Corporation Budesonide cyclodextrin formulation
EP2923702A1 (en) * 2014-03-28 2015-09-30 Universite De Liege Composition of cyclodextrin with budesonide derivatives for treatment and prevention of pulmonary inflammatory disease
CN106413759B (en) * 2014-03-28 2022-02-22 列日大学 Composition comprising cyclodextrin and budesonide derivatives for the treatment and prevention of pulmonary inflammation
WO2019217286A1 (en) 2018-05-07 2019-11-14 Prana Biosciences Inc Metaxalone formulations
EP3906263A4 (en) 2019-01-03 2022-08-31 Underdog Pharmaceuticals, Inc. Cyclodextrin dimers, compositions thereof, and uses thereof
CN113491677B (en) * 2020-03-18 2023-09-26 南京知和医药科技有限公司 Novel medicinal antiviral drug inhalant preparation and preparation method thereof
WO2022217029A1 (en) * 2021-04-09 2022-10-13 Arizona Board Of Regents On Behalf Of The University Of Arizona Compositions and methods for delivering pharmaceutical agents

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
US20040228805A1 (en) * 2002-08-17 2004-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
US20050065141A1 (en) * 2003-07-31 2005-03-24 Odink Debra A. Carbapenems useful in treating and preventing pulmonary infections, pharmaceutical compositions thereof and modes of administration thereof

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5376645A (en) * 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
US6598603B1 (en) * 1997-12-31 2003-07-29 Astra Aktiebolag Method for treating respiratory diseases
US20020183292A1 (en) * 2000-10-31 2002-12-05 Michel Pairet Pharmaceutical compositions based on anticholinergics and corticosteroids
GB0029562D0 (en) * 2000-12-04 2001-01-17 Novartis Ag Organic compounds
HUP0302891A2 (en) * 2001-01-31 2003-12-29 Pfizer Products Inc. Ether derivatives useful as inhibitors of pde4 isozymes, their use and pharmaceutical compositions containing them
EP1383445A4 (en) * 2001-03-20 2005-04-13 Cydex Inc Formulations containing propofol and a sulfoalkyl ether cyclodextrin
US20030055026A1 (en) * 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
EP2359859A1 (en) * 2002-12-09 2011-08-24 Abraxis BioScience, LLC Compositions comprising albumin nanoparticles and methods of delivery of pharmacological agents
WO2005051293A2 (en) * 2003-11-21 2005-06-09 Combinatorx, Incorporated Methods and reagents for the treatment of inflammatory disorders
KR20070007076A (en) * 2003-12-31 2007-01-12 사이덱스 인크 INHALANT FORMULATION CONTAINING SULFOALKYL ETHER gamma;-CYCLODEXTRIN AND CORTICOSTEROID

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5192528A (en) * 1985-05-22 1993-03-09 Liposome Technology, Inc. Corticosteroid inhalation treatment method
US5874418A (en) * 1997-05-05 1999-02-23 Cydex, Inc. Sulfoalkyl ether cyclodextrin based solid pharmaceutical formulations and their use
US20040228805A1 (en) * 2002-08-17 2004-11-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Pharmaceutical compositions for inhalation containing an anticholinergic, corticosteroid and betamimetic
US20050065141A1 (en) * 2003-07-31 2005-03-24 Odink Debra A. Carbapenems useful in treating and preventing pulmonary infections, pharmaceutical compositions thereof and modes of administration thereof

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
GESSLER ET AL.: "Ultrasonic versus jet nebulization of iloprost in several pulmonary ypertension?", EUROPEAN RESPIRATORY JOURNAL, vol. 17, 2001, pages 14 - 19, XP008129043 *

Also Published As

Publication number Publication date
WO2007075800A2 (en) 2007-07-05
WO2007075801A3 (en) 2008-12-31
WO2007075798A3 (en) 2008-11-20
EP1971347A2 (en) 2008-09-24
JP2009520822A (en) 2009-05-28
EP1973550A2 (en) 2008-10-01
BRPI0620225A2 (en) 2011-11-01
JP2009520823A (en) 2009-05-28
WO2007075798A2 (en) 2007-07-05
CA2634398A1 (en) 2007-07-05
WO2007075963A2 (en) 2007-07-05
WO2007075859A3 (en) 2008-12-11
WO2007075801A2 (en) 2007-07-05
EP1971349A2 (en) 2008-09-24
EP1971345A2 (en) 2008-09-24
EP1971348A2 (en) 2008-09-24
WO2007075799A2 (en) 2007-07-05
WO2007075798A9 (en) 2007-08-23
WO2007075799A3 (en) 2009-01-15
EP1971346A2 (en) 2008-09-24
JP2009520828A (en) 2009-05-28
WO2007075800A3 (en) 2008-11-20
CA2634413A1 (en) 2007-07-05
JP2009520821A (en) 2009-05-28
JP2009520827A (en) 2009-05-28
JP2009524590A (en) 2009-07-02
WO2007075859A2 (en) 2007-07-05

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