sunday, april 25 across societies â Experimental Biology

Sunday, April 25Across Societies – Experimental Biology444. Teaching, Learning and Testing in theBiological and Biomedical Sciences IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDEducationPresentation time: 12:30 p m-2:30 p mRecognizing that techniques and issues related to teachingand the use of computers in research and teaching cross allbiomedical disciplines, Experimental Biology 2010 has combinededucation posters from all participating societies. Please note:Posters are on display Sunday through Tuesday. Presentationtime is for Sunday only.T1 444.1 Learner assessment using interactive webbasedinstructional techniques enhances preclinical education.P.S. Klinkhachorn, E. Allen and F.D. Reilly. West VirginiaUniv.T2 444.2 Cadaver-based practicals versus electronicpracticals: same students, different exams. F. Daly. Univ. ofNew England.T3 444.3 Novel case-based learning approach tointegrate basic and clinical sciences. D.B. Averill, A. Yin, R.Miller, B. Engelbert and B.E. Wright. Ross Univ. Sch. of Med.,North Brunswick, NJ and Southwest Georgia Tech Col.T4 444.4 The Physician’s Statement: a novel test itemstrategy for medical education. B.E. Wright, D.B. Averill andH.F. Janssen. Ross Univ. Sch. of Med., Dominica and TexasTech Univ. Hlth. Sci. Ctr., El Paso.T5 444.5 Teaching pharmacology and pharmacovigilancein an integrated medical curriculum. C.L. Faingold andG.A. Dunaway. Southern Illinois Univ. Sch. of Med.T6 444.6 Relationships between pathophysiology courseperformance and primary care didactic and clinical coursesand NCCPA board scores. V.L. McCleary, C.C. Hosford, S.J.Kuntz, A.C. Larson, M.A.J. Laxen and J.M. McHugo. Univ. ofNorth Dakota Sch. of Med. & Hlth. Sci.T7 444.7 Teaching pathophysiology in a systemsbasedcurriculum: use of a Student Auscultation Manikin. D.E.Fitzovich and R.C. Yonts. Lincoln Mem. Univ. DeBusk Col. ofOsteo. Med., TN.T8 444.8 Thoracic-pulmonary mechanic model forthe comprehension of lung ventilation and water seal chestdrainage. A.C. Soto-Saucedo, J.A. Gómez-Gallardo-O’Leary, E. Almanza-Huante, L. Castillo-Hernández and A.Quintanar-Stephano. Autonomous Univ. of Aguascalientes,Mexico.T9 444.9 New tools for teaching energy transfer inbiology—effects of a randomized, controlled trial in progress.A. Batiza, M. Gruhl, T. Herman, D. Nelson and B. Zhang.Milwaukee Sch. of Engin., Gruhl Educ. Consultants LLC,Washburn, WI, Univ. of Wisconsin-Madison and Univ. ofWisconsin-Milwaukee.T10 444.10 Detecting protein unfolding with a UV light pen.L. West, L. Sherwood, S. Bergeron and P. DeLaLuz. LeeUniv., TN.445. Teaching, Learning and Testing in theBiological and Biomedical Sciences IIPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDEducationPresentation time: 1:30 p m-3:30 p mRecognizing that techniques and issues related to teachingand the use of computers in research and teaching cross allbiomedical disciplines, Experimental Biology 2010 has combinededucation posters from all participating societies. Please note:Posters are on display Sunday through Tuesday. Presentationtime is for Sunday only.T11 445.1 Investigation of the virtual physiology ofexercise laboratory. J. Dobson. Univ. of Florida.T12 445.2 Blood pressure and heart rate changes insimulated human apnea diving. Z. Valic, M. Valic, J.A. Giaconiand K. Peros. Univ. of Split Sch. of Med., Croatia, UCLA andUniv. of Zagreb Sch. of Dent., Croatia.T13 445.3 A physiological model of factors that determineskeletal muscle hemoglobin oxygen saturation. R.E. Klabunde.Ohio Univ.T14 445.4 A simple lab exercise to challenge student’sability to predict changes in the functional state of thecardiovascular system. R. Appleyard. Natl. Univ. of Hlth. Sci. ,IL.T15 445.5 Qualitative research to improve teaching ofexperimental, ethical and quantitative biology. S. Neroorkar, E.Gundlach and N. Pelaez. Purdue Univ.T16 445.6 Calibrated peer review: the application ofstatistical concepts to a biological research question. A.Dasgupta, S. Neroorkar, E. Gundlach and N. Pelaez. PurdueUniv.T17 445.7 Gender differences in thinking about ethical,experimental and quantitative biology related to functionaldiversity of the vasopressin and oxytocin receptor superfamily.D. Dutta and N. Pelaez. Purdue Univ.T18 445.8 Team-based learning: using case studiesand team exams to integrate physiological concepts. L.R.DeRuisseau. Le Moyne Col., NY.T19 445.9 Collaboration in the classroom: integratingfundamental physiological concepts through experimentaldesign and disease. K.M.S. Johnson. Beloit Col., WI.T20 445.10 From Claude Bernard to the Batcave andbeyond: using the life of the caped crusader to explore theintegrative physiology of stress, exercise and injury. E.P. Zehr.Univ. of Victoria, Canada.T21 445.11 Using general models, summary sheets andlearning paragraphs to integrate learning in physiology. M.P.Wenderoth. Univ. of Washington.T22 445.12 Interdisciplinary physiology: walkableneighborhoods, obesity and diabetes. J.L. McFarland.Edmonds Community Col., Lynnwood, WA.sun119

anatomyT23 445.13 Integrative learning of physiology and otherbiomedical sciences organized around primary care cases withhealthy patients. P.A. Hansen, S. Peters and M. Wells. Mem.Univ. of Newfoundland, Canada.T24 445.14 Playing a jeopardy-like quiz game to integratenew material in A & P. P.A. Halpin. Univ. of New Hampshire.sundayT25 445.15 Synthetic education in pathophysiology: role ofetiopathogenetic clusters. Z. Kovac. Med. Fac., Univ. of Zagreb,Croatia.T26 445.16 Frontiers in Physiology: a fellowship programthat fosters the teaching and learning of science. M. Limson,K.K. Ngo and M.L. Matyas. American Physiol. Soc.,Bethesda.Anatomy446. Anatomy Form and Variation: Neck,Thorax and AbdomenPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:00 p mC179 446.1 Anomalous muscle found between spleniusand suboccipital group of posterior cervical muscles. K.M.Gana and J. Ball. New York Chiropractic, Seneca Falls.C180 446.2 Morphology of the thoracic intervertebral disc inthe adult spine. H. Gillis, M. Johnson, B. Padfield, K. Obright,K. Galil and A.W. Hrycyshyn. Univ. of Western Ontario.C181 446.3 Morphology of longissimus thoracis andits clinical applications. M. Kumka and S.R. Truszkowski.Canadian Mem. Chiropractic Col., Toronto.C182 446.4 A detailed anatomical study of the papillarymuscles and chordae tendineae of the left ventricle in perfusionfixed human hearts. M.G. Bateman, C.E. Russell, B.Y. Chanand P.A. Iaizzo. Univ. of Minnesota, Minneapolis.C183 446.5 Factors influencing variation in the diameterof anterior and posterior intercostal arteries. R.D. Lane, C.Baptista, M. Hankin and C. Bennett-Clarke. Univ. of ToledoCol. of Med.C184 446.6 Location of sentinel lymph node in breastcancer. P.L. Matusz, A.M. Pusztai, D. Grujic, M. Mastacaneanuand T. Bratu. Univ. of Med. and Pharm. “Victor Babes” andEmergency County Hosp., Timisoara, Romania.C185 446.7 Segmentation of liver caudate lobe: study oncorrosion casts. P.L. Matusz and E-C. Hordovan. Univ. of Med.and Pharm. “Victor Babes”, Timisoara, Romania.C186 446.8 Aorto- and caval-renal corrosion casts madeby in situ injection. P.L. Matusz, P. Bordei, E. Sapte and B.Hoinoiu. Univ. of Med. and Pharm. “Victor Babes” Timisoaraand Fac. of Med., Univ. “Ovidius” Constanta, Romania.C187 446.9 Variation of the chorda tympani in theinfratemporal fossa. F. Dare, M. Ruiz and T.C. Crawford. DesMoines Univ. Col. of Osteo. Med.C188 446.10 Assessment of hepatic steatosis and fibrosisin embalmed cadavers. A.J. Kwong, E. Chu and K.M. Mak.Mount Sinai Sch. of Med.C189 446.11 Histochemical and immunohistochemicalstaining for markers of fibrosis in embalmed cadavers. K.M.Mak, E. Chu and A.J. Kwong. Mount Sinai Sch. of Med.C190 446.12 Study of multiple renal arteries using corrosioncasts and CT angiography. D.E. Zahoi, G.D. Miclaus, A. Alexa,D. Sztika and M. Farca. Univ. of Med. and Pharm. “Victor Babes”and Diagnostic Imaging Ctr. Neuromed, Timisoara, Romania.C191 446.13 Hepatopancreaticobiliary pathology in thePCK model of ARPKD. S.B. Mason, T. Eggleston-Gulyas, X.Lai, F.A. Witzmann and V.H. Gattone II. Indiana Univ. Sch. ofMed.447. Anatomy Form and Variation:ExtremitiesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:00 p mC192 447.1 Osseous anatomy of scapula obtained fromsouthwestern Nigerians. F.C. Osuagwu and O. Owoeye. DavidGeffen Sch. of Med. at UCLA and Univ. of Ibadan, Nigeria.C193 447.2 Variation in the bifurcation of the radial nerve:clinical implications. D.A. Ross, M. Kershaw and S. Marquez.SUNY Downstate Col. of Med.C194 447.3 Relationship of brachial artery blood flow rateand muscle activity in the anterior flexor compartment of thearm: a test of asymmetry. Y. Vilnits, C. Barry, G. Parnes, A.S.Pagano and S. Marquez. Col. of Med., SUNY Downstate andMount Sinai Sch. of Med.C195 447.4 An unusual branching pattern of the axillaryartery. K. Singh and R. Rao. Univ. of West Indies, Jamaica andJIPMER, Pondicherry, India.C196 447.5 Correlation between hard and soft tissuedimensions of the human foot. F.A. Narvaez, J. Cardona, A.S.Pagano and S. Marquez. SUNY Downstate Med. Ctr. andMount Sinai Sch. of Med.C197 447.6 An anatomic study of the genicular arterialanastomosis—a dissection and 3D model. M. Sabalbal and V.McAlister. Univ. of Western Ontario and Univ. Hosp.C198 447.7 An anatomical comparative study of lower limbdiscrepancy and scoliosis. L.M. Santoriello, W.R. Aibinder, A.Pagano and S. Marquez. SUNY Downstate Col. of Med. andMount Sinai Sch. of Med.C199 447.8 The bilateral nature and origin of the lateralcircumflex femoral artery. T. Ahamed, J. Abramowitz, A.S.Pagano and S. Marquez. SUNY Downstate Med. Ctr. andMount Sinai Sch. of Med.120

sunday448. Anatomy: Muscle, Tendons andLigamentsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:00 p mC200 448.1 Histologic analysis of horses afflicted withidiopathic laryngeal hemiplegia: nerve and muscular properties.J.W. Hermanson, S.M. Svoboda, J. Cheetham and N.G.Ducharme. Cornell Univ.C201 448.2 Morphological contribution of the pectoralismajor muscle to the stability of the pectoral girdle. M. Kumka.Canadian Mem. Chiropractic Col.C202 448.3 The frequency and predictability of the palmarislongus and plantaris muscles: a five year study. J. Abramowitz,T. Ahamed, J. Weedon and S. Marquez. SUNY DownstateCol. of Med.C203 448.4 The functional and comparative anatomy ofthe forelimb muscles in the sun bear (Helarctos malayanus). B.Adrian, M. Barton, S.Y. Tang and R.E. Fisher. Univ. of ArizonaCol. of Med.-Phoenix and Arizona State Univ.C204 448.5 Fixing the all variable of tendineous insertion inthe long abductor muscle of the thumb: dissection, dissectingroom, Medical School, National University San Agustin,Arequipa, Peru, 1998-2002. H-J. Mayta-Coaguila. Med. Fac.,Natl. Univ. of San Agustin, Peru.C205 448.6 The role of the transverse carpal ligamentin carpal stability: an in vitro study. H.E. Bortier, M.Tengrootenhuysen, R. van Riet, P. Pimontel and F. VanGlabbeek. Univ. of Antwerp, Univ. Hosp. of Antwerp, MonicaHosp., Deurne and Campus Stuivenberg, Antwerp, Belgium.449. Biological AnthropologyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:00 p mC206 449.1 The maxillary bone and its dental and softtissue interfaces in newborn primates. T.D. Smith and V.B.DeLeon. Slippery Rock Univ. and Johns Hopkins Univ.C207 449.2 Geometric morphometric investigation of sizeand shape in prosimian molar morphology: incorporatingphylogeny into allometric analyses. E. St Clair, D. Boyer, K.Baab and J. Perry. Stony Brook Univ. and Midwestern Univ.,IL.C208 449.3 The jaw adductor resultant vector in primates.J.M.G. Perry and R.L. Logan. Midwestern Univ., IL.C209 449.4 Heterochrony of cranial features associatedwith wide jaw gapes in common marmosets (callithrix jacchus).A.L. Mork and C.J. Vinyard. Northeastern Ohio Univs. Col. ofMed.C210 449.5 Anatomy of the facial musculature in twodiurnal anthropoid primates: exploring the relationship betweenfacial mobility and the muscles of facial expression. R.E.Kandath, K.M. Muldoon and S.D. Dobson. Dartmouth Col.and Dartmouth Med. Sch.C211 449.6 Basicranial and temporal bone morphology ofa sample of early human fossils. H.F. Smith. Arizona Col. ofOsteo. Med., Midwestern Univ.anatomyC212 449.7 Auditory functional analysis: lessons from theprimate auditory ossicles. Y. Carter and M.T. Silcox. Univ. ofSaskatchwan and Univ. of Winnipeg, Canada.C213 449.8 Distribution of mucusal surface area in nasaland paranasal spaces of a monkey and mouse lemur. T.D.Smith, T.P. Eiting and J.B. Rossie. Slippery Rock Univ., Univ.of Massachusetts Amherst and Stony Brook Univ.C214 449.9 Supernumerary lumbar rib in human prehistory.K.L. Eaves-Johnson. Univ. of Iowa.C215 449.10 The estimation of sex from lumbar spine. M.Jelaca-Tavakoli and M.E. Lewis. San Diego City Col. andUniv. of Reading, U.K.C216 449.11 Patterns of strain in the primate pelvis:implications for theoretical models of pelvic biomechanics. K.L.Lewton. Sch. of Human Evol. and Social Change, ArizonaState Univ.C217 449.12 What does modern human variation in MT1abduction angle and arch height reveal about hominid pedalmorphology? P.A. Kramer. Univ. of Washington.C218 449.13 Base composition changes indicate biasedgene conversion is a major factor in the evolution of the Fam53Agene. A.D. Bergemann, J.S. Reidenberg, J.T. Laitman, L.Skrabanek and I. Genecin. Mount Sinai Sch. of Med. andWeill Med. Col. of Cornell Univ.450. Growth and Development: Epigenetics,Teratogenesis and DiseasePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:00 p mC219 450.1 Efficacies of DNA and protein-based gammaglutamylcysteine synthetase (γgcs) vaccines fromLeishmania donovani on the cutaneous lesions in Leishmaniamajor-infected BALB/c mice. J.N. Alawa, A.J. Nok, H.O.Kwanashie and C.B. Alawa. Ahmadu Bello Univ., Nigeria andStrathclyde Inst. for Pharm. and Biomed. Sci., Glasgow.C220 450.2 Fetal malformations in mice caused by tapwater exposure. T.C. Hrubec, E.E. Ferguson, M.K. Mallelaand V.E. Keller. E. Via Virginia Col. of Osteo. Med. and VA-MDCol. of Vet. Med., Blacksburg.C221 450.3 Further characterization of a teratogen in tapwater. T.C. Hrubec, M.K. Mallela, J. Przbyla, F.A. Etzkorn andD. Blodgett. E. Via Virginia Col. of Osteo. Med., VA-MD Reg.Col. of Vet. Med., Virginia Tech.C222 450.4 Effect of low doses of nicotine on early aviandevelopment. P.R. Brauer, J.T. Olley, E.Q. Pham and M.V.Reedy. Creighton Univ.451. Growth and Development: Gene andProtein ExpressionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:00 p mC223 451.1 Positional variation in the molecular regulationof mammary gland development. J.M. Veltmaat. A*STAR Inst.of Molec. and Cell Biol., Singapore.C224 451.2 Functionality of bundle branches in developinghearts of Cx40 deficient mice. J. Benes, B. Sankova and D.Sedmera. First Fac. of Med., Charles Univ. in Prague.121sun

anatomyC225 451.3 Investigating the effects of zinc on rat neuralcrest cells using an in vitro model. H. Yang, C.L. Keen and L.Lanoue. Univ. of California, Davis.C226 451.4 Regulator of G protein signaling 3 modulatesWnt5b calcium dynamics and somite patterning. C.M.Freisinger and D.C. Slusarski. Univ. of Iowa.C227 451.5 Myogenin expression is independent of agrintreatment in C2C12 cell culture. W.A. Grow and J.B. Henley.Midwestern Univ., AZ.452. Growth and Development: Head andFacePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:00 p mC228 452.1 E.E. Just, Johannes Holtfreter, and the originof certain concepts in embryo morphogenesis. W.M. Byrnes.Howard Univ.C229 452.2 Assessment of a time-frame for postnatalchanges in the aerodigestive tract during the first year of life. H.Raja and J.T. Laitman. Mount Sinai Sch. of Med.C230 452.3 A craniosynostosis-syndrome related Fgfr2mutation promotes early craniofacial defects in chick. X. Li,S. Tropp and R. Marcucio. Sch. of Dent., UCSF and SanFrancisco Gen. Hosp.C231 452.4 Discovering interactions present during thegrowth and development of a craniofacial bone. K.L. Duenchand T. Franz-Odendaal. Saint Mary’s Univ. and Mount SaintVincent Univ., Halifax, Canada.C232 452.5 Cryptic emergence of craniofacial secondarymyoblasts. D.M. Noden and C. Lance-Jones. Cornell Col. ofVet. Med. and Univ. of Pittsburgh Sch. of Med.C233 452.6 Ephs and ephrins control palate fusion. I.Khobahy, S. San Miguel, M. Serrano, M. Miller, K. Svobodaand M.D. Benson. Texas A&M Hlth. Sci. Ctr. Baylor Col. ofDent.453. Growth and Development:ReproductionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:00 p mC234 453.1 Pathophysiological changes associated withsustained delivery of DHT and TP by means of hydroxyapatitedelivery system. H. Benghuzzi and M. Tucci. Univ. of MississippiMed. Ctr.C235 453.2 The effects of estrogen, parathyroid hormone,and testosterone on activated raw cells. M. Anderson, L.Rose, M. Tucci, H. Benghuzzi and J.A. Cameron. JacksonState Univ. and Univ. of Mississippi Med. Ctr.C236 453.3 VEGF induces cervical epithelial proliferationin mice: a molecular and morphological study. K.M. Scott,S.D. Kephart, S.B. Rhyne and C.N. Mowa. Appalachian StateUniv.C237 453.4 VEGF upregulates pro-inflammatory factors inthe cervix of mice. J. Schwabe, B. Boggess, B-T. Nguyen,P.G. Gosai, P. Tashakkori, N.K. Mowa and C.N. Mowa.Appalachian State Univ.454. Growth and Development: LimbDevelopment and GrowthPostersundaySu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:00 p mC239 454.1 Coincindent activation of the WNT and SHHpathways by FGF in the posterior limb bud. J.M. Van Arsdale ,J.M. Feenstra, C.U. Pira and K.C. Oberg. Loma Linda Univ.C240 454.2 How to attach the limb to the body axis. J.Streicher and C. Pomikal. Med. Univ. of Vienna.C241 454.3 The postnatal development of the feline distalphalanx. H.H. Bragulla and D.G. Homberger. LSU Sch. of Vet.Med.455. Imaging: AnatomyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:00 p mC242 455.1 An EGFP reporter system to visualizehomologous recombination in vivo. M.R. Sukup Jackson, V.Jonnalagadda, T. Matsuguchi and B.P. Engelward. MIT.C243 455.2 Multiphoton microscopy for detection of GFPlabeledmesenchymal stem cells in porcine AAA model. T.R.Shah, H.J. Shin, D.K. Han, E.Y. Galende, R.K. Malik, A.Salloum and P.L. Faries. Mount Sinai Med. Ctr.C244 455.3 Automated analysis of skeletal muscle fibercross-sectional area using CyteSeer image analysis program.T.Y. Kostrominova, R. Ingermanson, C.A. Laris, P. Loy andP.M. McDonough. Indiana Univ. Sch. of Med.-Northwest andVala Sci. Inc., San Diego.C245 455.4 Magnetic resonance imaging in evaluation oftumoral lesions of the heart. G.D. Miclaus, G. Catau, D.E. Zahoiand H. Ples. Diagnostic Imaging Ctr. Neuromed, Timisoara andUniv. of Med. and Pharm. “Victor Babes”, Romania.C246 455.5 MDCT in detection of anomalous coronaryorigin. G.D. Miclaus, D.E. Zahoi and H. Ples. DiagnosticImaging Ctr. Neuromed, Timisoara and Univ. of Med. andPharm. “Victor Babes”, Romania.C247 455.6 Anatomy of the azygos lobe and vein incostoclavicular compression with decreased venous return inpatients with thoracic outlet syndrome: MRI/MRA/MRV. J.D.Collins, E.H. Saxton, S.S. Ahn, H. Gelabert and A. Carnes.UCLA Sch. of Med.C248 455.7 Coexisting Chiari malformation and thoracicoutlet syndrome in patients presenting with migraine: MRI/MRA/MRV. E.H. Saxton, J.D. Collins, S.S. Ahn, H. Gelabertand A. Carnes. UCLA Sch. of Med.C249 455.8 Ultrasound-guided suprascapular nerve blocks:an anatomical pilot study. C. Barry, G. Parnes, Y. Vilnits, M.Stone and S. Marquez. SUNY Downstate Med. Ctr.C250 455.9 Differential pattern of fMRI signal in patients withmild cognitive impairment compared to healthy controls duringworking memory tasks involving a task-irrelevant fearful facedistracter. E. Tichenoff, M. McClure and A. Burhan. Univ. ofWestern Ontario and Lawson Hlth. Res. Inst., London, Canada.C251 455.10 Biometric iris recognition system evaluation.N.S. Latman and E. Herb. West Texas A&M Univ.122

sundayBiochemistryBiochemistry and Molecular Biology456. Chromatin and TranscriptionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB1 456.1 Chromatin-associated HMG-17 is a majorregulator of transcription factor activity modulated by Wnt/betacateninsignaling. B.A. Amendt and J. Wang. Texas A&M Hlth.Sci. Ctr. at Houston.B2 456.2 Mechanisms of transcription repression byHIV-1 Vpr binding protein. W. An. Univ. of Southern California.B3 456.3 The regulation of SWI/SNF chromatinremodeling complexes on human genes under heat shock andIFN-gamma treatment. M-B. Cheng, Y. Zhang, Y. Zhang andY-f. Shen. Chinese Acad. Med. Sci., Beijing.B4 456.4 Role of the H4K20me1/H3K9me1 trans-tailhistone code in transcriptional regulation. L.M. Congdon, J.K.Sims and J.C. Rice. Univ. of Southern California.B5 456.5 CDK8 is a positive regulator of transcriptionalelongation within the serum response network. J.M. Espinosa,A.J. Donner, M. Galbraith, D. Taatjes and C. Ebmeier. Univ.of Colorado at Boulder.B6 456.6 Hepatic eEF2K downregulation is associatedwith altered nucleosome positioning in neonatal IUGR rats.Q. Fu, R.A. McKnight, X. Yu, C.W. Callaway and R.H. Lane.Univ. of Utah.B7 456.7 Interactions between the U2 snRNP and SAGAreveal new links between co-transcriptional RNA splicing andchromatin modification. T.L. Johnson. UCSD.B8 456.8 Inhibiting the 26S proteasome expandsglucocorticoid receptor transcriptional networks via chromatinmodifications. H.K. Kinyamu, J. Yang and T. Archer. NIEHS,NIH, Research Triangle Park.B9 456.9 MLL histone methylases in estrogen-mediatedregulation of HOX genes involved in hair follicle developmentand leukemia. S.S. Mandal, K.I. Ansari, I. Hussain, S. Kasiriand B. Shrestha. Univ. of Texas at Arlington.B10 456.10 Regulation of the transcription of the UbDpromoter and identification of ISRE sequence. J. Oliva, F.Bardag-Gorce and S.W. French. LABioMed, Torrance.B11 456.11 Molecular and genetic studies of histonemodifyingcomplexes in thyroid hormone action during Xenopusdevelopment. Y-B. Shi. NICHD, NIH.B12 456.12 UBC9-mediated sumoylation of PR-Set7 isinvolved in regulation of gene repression. T.M. Spektor andJ.C. Rice. Univ. of Southern California.B13 456.13 Uncovering a conserved role for JMJD2 histonetridemethylases from worm to human. J.R. Whetstine, J.C.Black, A. Allen, E. Forbes, A. Smallwood, M. Longworth, K.Tschoep, B. Ulmschneider, R. Walsh, B. Ren and N. Dyson.Massachusetts Gen. Hosp., Harvard Med. Sch., Charlestownand UCSD Sch. of Med.457. Chromatin ModificationsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB14 457.1 Role of Gbg in regulation of class II histonedeacetylases. H. Budayeva, H.E. Hamm and B.D. Spiegelberg.Rider Univ. and Vanderbilt Univ.B15 457.2 Expression of DNA methyltransferases andtheir variants are altered in male IUGR rat liver. H.D. Cox, B.Burshears, C.W. Callaway, X. Yu, R.A. McKnight and R.H.Lane. Univ. of Utah.B16 457.3 Cloning of histone genes from Giardia lambliafor studies of post-translational modification. J. Donkersloot,L. Guerra, B. Lamphear, A. Best and M. Pikaart. Hope Col.B17 457.4 H2B ubiquitylation regulates nucleosomestability at replication forks. C-Y. Lin, M-Y. Wu, S-I. Tseng,G-S.W. Hsu and C-F. Kao. ICOB, Acad. Sinica and Fu-JenCatholic Univ., Taiwan.B18 457.5 Temporally and functionally mapping the SV40epigenome. B. Milavetz, A. Gefroh and L. Balakrishnan. Univ.of North Dakota and Univ. of Rochester.B19 457.6 Phosphorylation of histone H1 at specific sitesduring gene transcription. C.A. Mizzen, Y. Zheng, J. Pesavento,J. Schultz-Norton, S. John, A. Nardulli, N. Kelleher and G.Hager. Univ. of Illinois, Urbana and NCI, NIH.B20 457.7 Roles for epigenetic modifications atproinflammatory genes in tumor metastatasis. A.D. Truax andS.F. Greer. Georgia State Univ.B21 457.8 The histone H2A N-terminal tail regulates H2Bmonoubiquitylation and H3 K4 methylation via a novel trans tailpathway. S. Zheng and J.C. Reese. Penn State.458. Chromatin Recognition and AssemblyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB22 458.1 Kinetic mechanism of a novel HAT-histonechaperone complex, Rtt109-Vps75. B.N. Albaugh and J.M.Denu. Univ. of Wisconsin-Madison.459. Chromatin Structure in Gene ActivationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB23 459.1 p300 Mediates DNA looping between farupstream enhancer and core promoter of human iNOS gene.Z. Guo, L. Shao and D. Geller. Univ. of Pittsburgh.B24 459.2 Enrichment of short interspersed transposableelements in hypomethylated genic regions in embryonic stemcells. H. Muramoto, S. Yagi, K. Hirabayashi, S. Sato, J.Ohgane, S. Tanaka and K. Shiota. Univ. of Tokyo.sun123

iochemistry460. Covalent Modifications of Histonesand DNAPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB25 460.1 Structural basis for the recognition of Set1family Win motifs by WDR5. V. Dharmarajan, A. Patel, V.E.Vought and M.S. Cosgrove. Syracuse Univ.B26 460.2 Binge alcohol inhibits hepatic class I and IIhistone deacetylases: potential mechanism for alcohol-inducedliver injury. I. Kirpich, L. Gobejishvili, G. Kharebava, J. Zhang,C. McClain and S. Barve. Univ. of Louisville and Louisville VAMed. Ctr.B27 460.3 The effects of histone modifications on lenscell denucleation. R.P. Sheehan and M. Duncan. Univ. ofDelaware.B28 460.4 Mammalian tethered catalysis: a novel in vivoapproach to identify and characterize histone posttranslationalmodification binding proteins. C.T. Tuzon, T.M. Spektor andJ.C. Rice. USC Keck Sch. of Med.B29 460.5 Identification and maturation of newlysynthesized fungal histone H3. J.H. Waterborg. Univ. ofMissouri-Kansas City.461. RNA Polymerase Structure andMechanismsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB30 461.1 A stopped-flow kinetic analysis of substratebinding and catalysis by Escherichia coli RNA polymerase.R.S. Johnson and M. Strausbauch. Brody Sch. of Med., EastCarolina Univ.B31 461.2 The b subunit gate loop mediates antiterminationmodification of RNA polymerase. A. Sevostiyanova, G.A.Belogurov and I. Artsimovitch. Ohio State Univ. and Univ. ofTurku, Finland.462. Transcriptional Assemblies andMechanismsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB32 462.1 Estradiol (E2) regulation and ERa, C/EBPband SP1 interactions are essential for human prolactin receptorgene transcription in a live cell-based system. J-H. Kang, C-H.Tsai-Morris and M.L. Dufau. NICHD, NIH.463. Enzyme MechanismPostersundaySu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB33 463.1 Molecular modulation of the alpha-subunitVISIT-DG sequence in the catalytic sites of Escherichia coliATP synthase. Z. Ahmad and L.E. Brudecki. East TennesseeState Univ.B34 463.2 Mechanistic insights into the function of thea-helical tail in Haemophilus influenzae 3-deoxy-d-mannooctulosonate8-phosphate phosphatase. L.M. Briski, A.Hanuszkiewicz and R.W. Woodard. Kalamazoo Col. and Univ.of Michigan.B35 463.3 Hemoglobin-induced oxidative stress isassociated with both endogenous peroxidase activity and H 2O 2generation from polyunsaturated fatty acids. T-M. Cheng, J-P.Pan, H-W. Chen, Y-C. Chang and C-C. Chang. Col. of Biol. Sci.and Technol., Natl. Chiao Tung Univ., Taiwan, Taipei VeteransGen. Hosp. and Inst. of Physics, Acad. Sinica, Taipei.B36 463.4 Identification and characterization of a 3-deoxyd-manno-oct-2-ulosonicacid (Kdo) oxidase. H.S. Chung andC.R.H. Raetz. Duke Univ. Med. Ctr.B37 463.5 A kinetic analysis of each step of proteinsplicing of the Pyrococcus abyssi PolII intein. L.R. Duffee, D.J.York, D.M. Dorval, J.N. Reitter and K.V. Mills. Col. of the HolyCross.B38 463.6 Computational approach to investigate thecatalytic chemical reaction mechanism of glyoxysomal malatedehydrogenase. H. Guterres and E. Bell. Univ. of Richmond.B39 463.7 Catalytic activity of HDAC8 and HDAC11. C.G.Joseph, M. Fuchter and C. Fierke. Univ. of Michigan andImperial Col. London.B40 463.8 Size and stability are critical elements in thesubstrate selectivity of insulin-degrading enzyme. V. Kalas,L.A. Ralat, Z. Zheng, T.R. Sosnick and W-J. Tang. Univ. ofChicago.B41 463.9 Mutational disruption of the nitric oxidesynthase/calmodulin interaction causes increased formation ofreactive oxygen species. D.L. Kellogg III, B.S.S. Masters andL.J. Roman. Univ. of Texas Hlth. Sci. Ctr. at San Antonio.B42 463.10 Order of phosphorylation events in activationof ribosomal protein S6 kinase 1. M.M. Keshwani and S.S.Taylor. UCSD.B43 463.11 Mechanism and inhibition of thedihydroxynaphthoyl-CoA synthase MenB from Mycobacteriumtuberculosis. N. Liu, X. Li and P.J. Tonge. Stony Brook Univ.B44 463.12 Non-canonical inteins: alternate mechanismsfor protein splicing. K.V. Mills, J.N. Reitter, L.R. Duffee, D.J.York, D.M. Dorval and K.T. Lewandowski. Col. of the HolyCross.B45 463.13 Manipulation of protein splicing side-reactionsto facilitate protein purification and expressed protein ligation.A.C. Nadelson, D.J. York, D.M. Dorval, K.T. Lewandowski,K.R. Connor, J.N. Reitter and K.V. Mills. Col. of the HolyCross.B46 463.14 Ubiquitin carboxy hydrolase-L3: a molecularsensor of protein stability? O. Romo-Fewell, M. Navarro andJ.J. Love. San Diego State Univ.B47 463.15 Site-directed mutagenesis of a novel secondaryalcohol dehydrogenase from M. luteus WIUJH20. N. Shoger,J-K. Huang and L. Wen. Western Illinois Univ.124

iochemistry468. Regulation and AllosterismPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB70 468.1 The functional architecture of a cationic porethat modulates citrate synthase quaternary structure andallostery. G.D. Brayer, R. Maurus, D. Stokell, L.J. Donald, N.Nguyen and H.W. Duckworth. Univ. of British Columbia andUniv. of Manitoba.B71 468.2 R- to T-transition in fructose-1,6-bisphosphatase:loop displacement is the penultimate step to inactivation. Y.Gao, C.V. Iancu, S. Mukund and R.B. Honzatko. Iowa StateUniv.469. Structural EnzymologyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB72 469.1 Structure of the first fungal enzyme form ofaspartate b-semialdehyde dehydrogenase. B.T. Arachea, X.Liu, A. Pavlovsky and R.E. Viola. Univ. of Toledo and YaleUniv. Sch. of Med.B73 469.2 Structural basis of inter-domain electrontransfer in human Ncb5or. B. Deng, S. Parthasarathy, W.Wang, S.W. Lovell, D.R. Benson and H. Zhu. Univ. of KansasMed. Ctr. and Univ. of Kansas.B74 469.3 The varied roles of conserved arginine residuesnear beta-turns in glyoxysomal malate dehydrogenase. S.Hedrick and E. Bell. Univ. of Richmond.B75 469.4 Structure-function studies of the regulatorybicarbonate binding in H. influenzae carbonic anhydrase: afunctional reversion of allostery using multiple site mutations.K.M. Hoffmann and R.S. Rowlett. Colgate Univ.B76 469.5 Structural genomics of cancer-preventivephenylpropanoid biosynthetic pathway enzymes. W. Kim, H.J.Yang, Y.J. Yun, Y.H.H. Kim, T. Kwon, C. Kang and B. Youn.Pusan Natl. Univ., Republic of Korea and Washington StateUniv. Sch. of Molec. Biosci.B77 469.6 Kinetic and structural studies of Haemophilusinfluenzae carbonic anhydrase with altered proton transfercapacity. G. Lam, J. Ciaccia and R.S. Rowlett. Colgate Univ.B78 469.7 Characterization of a dimeric arginine kinase inthe protozoan, Phytophthora sojae, suggests an early origin ofphosphagen kinase dimers. A.K. Palmer, D. Fraga, M. Sniderand P. Edmiston. Col. of Wooster, OH.B79 469.8 Spectroscopic and structural studies of themechanism of bicarbonate-induced allostery in Haemophilusinfluenzae carbonic anhydrase. R.S. Rowlett, D. Samardzic,H. Failing, J. Williams, M. Mysliwiec and I. Stanford. ColgateUniv.B80 469.9 An effective docking model for rapid screeningof potential xanthine oxidase inhibitors. A. Stockert, L.Fakunmoju and T. Mahfouz. Ohio Northern Univ.B81 469.10 Novel alpha-glucosidase from human gutmicrobiome—substrate specificity and switch. K. Tan, C.Tesar, R. Wilton, L. Keigher, G. Babnigg and A. Joachimiak.Argonne Natl. Lab.sunday470. Structural Enzymology of MembraneProteinsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB82 470.1 A tangible 3D model of the human adipocyteplasma membrane-associated protein. Galileo SMART Team,S. Colton, T. Herman, K. Giles, B. Koo, S. Jeske, M. Hicks andS. DeBella. Galileo Acad. of Sci. & Technol., San Francisco,Milwaukee Sch. of Engin. and UCSF.471. tRNA Synthetases: Structure,Mechanism and EvolutionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p m7:30B83 471.1 Metazoan mitochondrial alanyltRNAsynthetases – varying roles for a C-terminal domain. J.Chihade, D. Anderson, K. Borchert, J. Brown, A.J. Mork, N.Natala and Y. Zhu. Carleton Col., MN.472. Emerging Concepts in the Physiologyand Pathology of Lipid MetabolismPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB84 472.1 Eicosanoid regulation of hemostasis throughconcomitant signals in the human platelet. M. Holinstat, J.Vesci, P.L. Apopa and O. Boutaud. Thomas Jefferson Univ.and Vanderbilt Univ.B85 472.2 Regulation of cholesterol biosynthetic geneexpression by the Ah receptor. R. Tanos, R.D. Patel and G.H.Perdew. Penn State.B86 472.3 ACSVL3 depletion in U87 glioma cells affectsboth fatty acid and cholesterol homeostasis. P. Watkins, E.Kolar and Z. Pei. Kennedy Krieger Inst., Baltimore and JohnsHopkins Univ. Sch. of Med.473. Enzymology of Lipid MetabolizingEnzymesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB87 473.1 Short-term feeding effects of Origanumsyriacum crude extract on blood constituents in rats. T. Al-Qirim, M. Shahwan and A. Bader. Al-Zaytoonah Univ. ofJordan.B88 473.2 Structural and functional analysis ofphospholipid-specific nucleotide pyrophosphatase/phosphodiesterase isoforms. D.L. Baker, I. Wanjala, T.C.Pham, A. Howard, J. Cox and A. Parrill. Univ. of Memphis.126

sundayB89 473.3 The C-terminus of a subunit determines thecatalytic activity of AMP-activated protein kinase. X. Cui,H. Gao, J-K. Hwang and J.Y-J. Shyy. Univ. of California,Riverside, Qi-Lu Hosp. of Shandong Univ., People’s Republicof China and Natl. Chiao Tung Univ., Taiwan.B90 473.4 Freshwater mollusc thiolase cloning, expressionand structural analysis. J.H. Dyer and R. Prezant. MontclairState Univ.B91 473.5 Hemi-bis(monoacylglycero)phosphatecomposition and biosynthesis in Escherichia coli. T.A. Garrettand R.L. Rose. Vassar Col.B92 473.6 Crystal structure and acyl chain selectivityof Francisella novicida LpxA, the first enzyme in lipid Abiosynthesis. S.H. Joo and C.R.H. Raetz. Duke Univ.474. Lipid Interactions in Physiology andDiseasePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB93 474.1 Feeding omega-3 fatty acids from differentsources on tissue fatty acid composition and oxidative stabilityin rats. E. Cordonier, S.N. Altman, J. Gigliotti and J.C. Tou.West Virginia Univ.B94 474.2 Effects of particle size and protein compositionon structural stability and functional remodeling of human highdensitylipoproteins. X. Gao, S. Yuan, S. Jayaraman and O.Gursky. Boston Univ. Sch. of Med.B95 474.3 A novel control point in cholesterol biosynthesis.S. Gill, J. Stevenson, I. Kristiana and A.J. Brown. Sch. ofBiotechnol. and Biomolec. Sci., Univ. of New South Wales.B96 474.4 Novel anti-aging small molecules greatlyextend yeast life span by specifically targeting a mechanismunderlying the essential role of cellular lipid movement andcompartmentalized metabolism in regulating longevity. V.Titorenko, A. Goldberg, S. Bourque, A. Beach, M. Burstein,V. Richard, P. Kyryakov, C. Gregg, T. Boukh-Viner and M.Juneau. Concordia Univ., Canada.B97 474.5 By increasing the level of cardiolipin in the innermitochondrial membrane, a novel anti-aging small moleculemodulates many longevity- and disease-related processesin mitochondria. V. Titorenko, A. Goldberg, S. Bourque, A.Beach, M. Burstein, V. Richard, P. Kyryakov, C. Gregg, T.Boukh-Viner and M. Juneau. Concordia Univ., Canada.B98 474.6 Effects of fatty acids on the growth of beta-cellsand on albumin-mediated cholesterol effflux from endothelialcells. V.C. Tuei, J-S. Ha, N.V. Bhagavan and C-E. Ha. Univ. ofHawaii.475. LipidomicsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB99 475.1 Effects of omega-3 fatty acids on lipidmetabolism and signaling using lipidomic analyses. J.D.Brooks, P.C. Norris and E.A. Dennis. UCSD.BiochemistryB100 475.2 Lipidomic analysis of carrageenan-inducedhyperalgesia reveals bilateral eicosanoid production in thespinal cord. D.S. Dumlao, M. Buczynski, C. Svensson, B.Fitzsimmons, J. Wirkus, F. Jacobsen, X-Y. Hua, T. Yaksh andE.A. Dennis. UCSD.B101 475.3 Quantification of prostaglandin D synthasepeptides in human cerebrospinal fluid by selective reactionmonitoring. A.N. Fonteh, D. Fisher, R. Biringer, A. Huhmer,J. Rush and M. Harrington. Huntington Med. Res. Insts.,Pasadena, Thermo Fisher Scientific, San Jose and CellSignaling Technol., Danvers, MA.B102 475.4 Increased ceramide accumulation correlateswith downregulation of the autophagy protein ATG-7 in MCF-7cells sensitized to photodamage. D. Separovic, A. Kelekar, A.Nayak, A. Tarca and J. Bielawski. Wayne State Univ., Univ. ofMinnesota, Minneapolis and Med. Univ. of South Carolina.B103 475.5 Studies on the chemical synthesis ofN-acylphosphatidylethanolamine. J. Son and T.A. Garrett.Vassar Col.B104 475.6 Investigation of lipid-based assembly of viralparticles. A. Zofkie, C.M. Cossell, E. Adu-Gyamfi and R.V.Stahelin. Univ. of Notre Dame and Indiana Univ. Sch. of Med.-South Bend.476. Lipids and InflammationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB105 476.1 Production of chlorinated lipids in neutrophilmediatedinflammation. D.S. Anbukumar, L.P. Shornick, C.J.Albert and D.A. Ford. Saint Louis Univ.B106 476.2 The role of interleukin 1 receptor-associatedkinase 1 in lipid metabolic alterations associated withendotoxemia. S.M. Chang, U. Maitra and L. Li. Virginia Tech.B107 476.3 Phosphatidylethanolamine modificationcontributes to levuglandin/isoketal-induced cytotoxicity. S.S.Davies, C.B. Sullivan, E. Matafonova, L.J. Roberts II and V.Amarnath. Vanderbilt Univ.B108 476.4 JAM-A regulates the progression of nonalcoholicfatty liver disease. M.E. Kissig and U.P. Naik. Univ. ofDelaware.B109 476.5 Inhibition of SCD activity enhances inflammationin RAW264.7 macrophages but improves cholesterol trafficking.X. Liu, D. Joo, Z. Akhtar and J. Ntambi. Univ. of Wisconsin-Madison.B110 476.6 Differential regulation of IL-27 expressionduring inflammatory stress in adipocytes. H. Nam, B.S.Ferguson, C.F. Rainey, R.G. Hopkins, J.M. Stephens andR.F. Morrison. Univ. of North Carolina at Greensboro andLSU.B111 476.7 Fatty acids modulate Toll-like receptor 4activation through regulation of receptor dimerization andrecruitment into lipid rafts in a ROS dependent manner. S.Wong, M-J. Kwon, R. Snodgrass, A.M.K. Choi, H-P. Kim, K.Nakahira and D. Hwang. USDA and Univ. of California, Davisand Harvard Med. Sch.B112 476.8 Three-tier model for inflammasome expressionand a new concept of inflammation privilege. X-F. Yang, Y. Yin,J. Mai, F. Liu, X. Jiang and H. Wang. Temple Univ. Sch. ofMed.sun127

iochemistry477. Pharmacological Targets in LipidMetabolismPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB113 477.1 Inhibition of proprotein convertase subtilisin/kexin type 9 secretion by prodomain overexpression or pefabloctreatment as measured by a luciferase assay. L. De Vries, C.Robichon, C. Cathala, M. Perez, D. Junquero and D. Cussac.Pierre Fabre Res. Inst., Castres, France.B114 477.2 HIV protease inhibitors differentially regulatePPARg expression in adipocytes. B.S. Pecora, W. Zha, P.B.Hylemon, M. Wabitsch and H. Zhou. Virginia CommonwealthUniv. and Univ. of Ulm, Germany.478. Protein-Lipid InteractionsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB115 478.1 Thermodynamic and kinetic analysis ofmembrane protein insertion: case of diphtheria toxin T-domain.A.S. Ladokhin, J. Brettmann, A. Kyrychenko, Y.O. Posokhov,M.V. Rodnin and A. Thoma. Univ. of Kansas Med. Ctr.B116 478.2 Single tryptophan mutants of apolipophorin III:binding interaction to lipopolysaccharides. D. Martinon and P.Weers. California State Univ., Long Beach.B117 478.3 Initiation of lipid binding in Locusta migratoriaapolipophorin III. Y.M. Phung, J. Rodriguez, D. Martinon, G.Abdullahi and P.M.M. Weers. California State Univ., LongBeach.B118 478.4 Mutant FAR protein construction and theirpotential as vaccine candidates. M. Scheidt, J. Bath, A.Bakken, C. Clark, P. Eneh and M. Knox. Concordia Col., MN.B119 478.5 Interdisciplinary studies of the multifacetedC2 domains. R.V. Stahelin, H. Yu, D. Olmstead and C.Gunasekaran. Indiana Univ. Sch. of Med., South Bend andUniv. of Notre Dame.B120 478.6 Molecular architecture of viral assembly andbud site formation. R.V. Stahelin, E. Adu-Gyamfi, H. Yu, C.M.Cossell and A. Zofkie. Indiana Univ. Sch. of Med., South Bendand Univ. of Notre Dame.479. Structural Biology and Mechanisms ofMembrane Lipid AssemblyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB121 479.1 Quantification of glycerophospholipids inEscherichia coli. M.L. Hopson and T.A. Garrett. Vassar Col.480. Glycobiology and ExtracellularMatrixPostersundaySu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB122 480.1 The role of syndecan-1 in arterialmechanotransduction. A.B. Baker, V. Chitalia, B.G. Steyer, S.Hirji and E.R. Edelman. MIT and Boston Univ. Sch. of Med.B123 480.2 Matrigel TM invasion and migration of capillaryendothelial cells are blocked by tunicamycin a glycosylationinhibitor. A. Banerjee, E. Duran, K. Baksi and D.K. Banerjee.Univ. of Puerto Rico and Univ. Central del Caribe, PR.B124 480.3 Chemoenzymatic synthesis of sialyl Lewis xcontaining different sialic acid forms. R.W. Huang, K. Lau, G.Sugiarto, V. Thon, Y. Li and L. Ding. Univ. of California, Davis.B125 480.4 Mutations in fibrillin-1 leading to classicaland neonatal Marfan syndrome cause differential proteasesusceptibilities and protein function. D. Hubmacher, R.Kirschner, G. Iyengar, D. Bromme, R. Bartels and D.P.Reinhardt. McGill Univ., Univ. of British Columbia and BorstelRes. Ctr., Germany,.B126 480.5 Biochemical response and secretion ofextracellular protein and carbohydrate by Pseudomonasputida grown on fluoranthene and hydrogen peroxide. M.N.Igwo-Ezikpe, G.O. Gbenle, M.O. Ilori, J. Okpuzor and A.A.Osuntoki. Univ. of Lagos, Nigeria.B127 480.6 Secretor phenotype and genotype are novelpredictors of severe outcomes in premature infants. A.L.Morrow, J. Meinzen-Derr, P. Huang, K.R. Schibler, T. Cahill,S.G. Kallapur, D.S. Newburg, M. Tabangin, B.B. Warner andX. Jiang. Cincinnati Children’s Hosp. Med. Ctr., MassachusettsGen. Hosp., Charlestown and Washington Univ.B128 480.7 Trypanosoma cruzi and its gp83 ligandmodulate host thrombospondin 1 and laminin g-1 gene networksto recruit trypanosomes in the early infection process. P. Nde,T.C. Cardenas, C.A. Johnson, S. Pratap, Y.Y. Kleshchenko,V.A. Furtak, M.F. Lima and F. Villalta. Meharry Med. Col.B129 480.8 The goldilocks effect: identifying the mechanismby which O-GlcNAc regulates the expression of OGT andO-GlcNAcase in response to changes in cellular state. B.Nimaga, S. Doshi and N.E. Zachara. Johns Hopkins Univ.Sch. of Med. and UCSD.B130 480.9 Modulation of sarcoma cell movement andmatrix interaction following manipulation of cell surfaceproteoglycans. S. Rossi, K. Lacrima, E. Garusi, P.A. Nicolosi,S. Affò, M. Gulli, G. Gobbi, M. Vitale and R. Perris. Univ. ofParma and Natl. Tumour Inst. of Aviano, Italy.B131 480.10 The role of fibronectin in microfibril assemblyand homeostasis. L. Sabatier, C. Fagotto-Kaufmann, D.Chen, D.S. Annis, D.F. Mosher and D.P. Reinhardt. McGillUniv. and Sch. of Med. and Publ. Hlth., Univ. of Wisconsin.B132 480.11 Asparagine-linked oligosaccharides presenton a nonconsensus amino acid sequence in the CH1 domainof human antibodies. J.F. Valliere-Douglass, C.M. Eakin, P.Kodama, M. Mujacic, L.J. Brady, W. Wang, A. Wallace, B. Yan,P. Reddy, M.J. Treuheit and A. Balland. Amgen Inc., Seattle.B133 480.12 Effect of precursor structures on the action ofheparan sulfate biosynthetic enzymes. X.V. Victor, P. Babu, E.Nelsen and B. Kuberan. Univ. of Utah.128

sundayB134 480.13 Kinetics of yeast dissociation from lectin beads:I. alpha methyl mannose. G.C. Zem, J. Dreyfuss, J. Allen, R.Kawashima, E. Daco, Y. Kanda, J. Yaghoobian, S. Danialian,W. Givens, A. Baghoomian, N. Zograbyan, S. Haroutounian,N. Bimanand, S. Silani, H. Khorrami, M. HashemiehShirazi, K. Keihani, G. Tafreshi, A. Jahanbakhsh, A. Solati,H. Balazadeh, H. Phan, L. Papazian, A. Moayer and S. B.Oppenheimer. California State Univ., Northridge.B135 480.14 Kinetics of yeast dissociation from lectinbeads: II. alpha methyl glucose. G.C. Zem, J. Dreyfuss, J.Allen, R. Kawashima, E. Daco, Y. Kanda, J. Yaghoobian, A.Cochrane, J. Sobhani, K. Pouromid, S. Jahanian, A. Solati,H. Balazadeh, D. Hernandez, M. Cortes, K. Kermani andS.B. Oppenheimer. California State Univ., Northridge.B136 480.15 Kinetics of yeast dissociation from lectin beads:III. potassium chloride. G.C. Zem, J. Dreyfuss, J. Allen, R.Kawashima, E. Daco, Y. Kanda, T. Koleilat, M. Khurrum, J.Yaghoobian, S. Danialian, M. Marroquin, L. Wolfenden andS.B. Oppenheimer. California State Univ., Northridge.B137 480.16 In vitro reconstitution of a bacterialpolysaccharide biosynthetic pathway. G. Zhao, R. Woodward,W. Yi, L. Li, H. Eguchi, E. Motari, L. Cai, X. Liu, J.K. Song, W.Han, W. Zhang and P.G. Wang. Ohio State Univ. and Col. ofPharm., Nankai Univ., People’s Republic of China.481. Lipid Domains and Lipid RaftsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB138 481.1 Age related decrease in postsynaptic signalingcomponents and caveolin-1 in membrane/lipid rafts andsynaptosomal membrane fractions in the CNS. J. Bonds, H.H.Patel, D.M. Roth, J.N. Peart, P.M. Patel and B.P. Head. UCSDand Sch. of Med. Sci., Griffith Univ., Australia.B139 481.2 Lipid rafts determine association of Orai1,STIM1 and the TRPC1 and TRPC6 proteins. J.A. Rosado, C.Galan and G.M. Salido. Univ. of Extremadura, Spain.482. Structure, Function, and Biogenesis ofCell MembranesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB140 482.1 Mitochondrial dysfunctions induced by oxidativestress in Caco-2 cells. T. Rame, E. Seidman, J.F. Beaulieu,F. Boudreau, F.P. Gendron, E. Delvin, A. Devendra and E.Levy. Univ. of Montreal, McGill Univ. and Fac. of Med., Univ. ofSherbrooke, Canada.483. ADAMS and Other ProteasesPosterBiochemistrySu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB141 483.1 Acute hypoxia responsive element as a newtool detecting acute hypoxia. M.Z. Cilek, S. Hirohata, O.F.Hatipoglu and Y. Ninomiya. Okayama Univ. Grad. Sch. ofMed., Dent. and Pharmaceut. Sci.B142 483.2 Urokinase plasminogen activator receptoractivation of invasion and migration in H460 cells requires Na + /H + transporter activity and expression. C. Kutz, A. Haak, D.E.Rasted, J.J. Provost and M.A. Wallert. Minnesota State Univ.Moorhead.B143 483.3 Tissue-specific regulation of calpain andcalpastatin activities by PIN1 in mice. R.A. Schneider, T. Liuand D.G. Hoyt. Col. of Pharm., Ohio State Univ.484. AgingPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB144 484.1 Effect of chronic estradiol-17b (E2) exposure onthe expression of genes related to inflammation in the arcuatenucleus of female rats: effects of aging. L. Jagannathan, S.MohanKumar and P. MohanKumar. Michigan State Univ.B145 484.2 Changes in BACE1 and BACE2 expresssion inAlzheimer’s disease and Down syndrome. A. Laux, R. Webb,C. Holler, A. Dowling, T. Beckett and M.P. Murphy. Univ. ofKentucky Col. of Med.B146 484.3 Effect of Fucus evanescensf ucoidan onexpression of matrix metalloproteinase-1 promoter, mRNA,protein and signal pathway. Y.H. Lee and M.J. Ku. Inst. ofNatural Prods. for Hlth. Promotion, Busan, Republic of Korea.B147 484.4 Uncovering novel mechanisms for limitingthe accumulation of isoaspartyl-damaged proteins. A.N.Patananan. UCLA.485. Apoptosis and Cell Stress IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mPart II - Monday, April 26thB148 485.1 Calcium/calmodulin-dependent protein kinaseII links hepatic cytosolic calcium release and apoptosis afterburn injury. N.C. Brooks, D. Boehning and M. Jeschke. Univ.of Texas Med. Branch and Shriners Hosps. for Children.B149 485.2 Caspofungin induces programmed cell deathin Saccharomyces cerevisiae. C. Chin, K. Helming and N.Austriaco. Providence Col. and Harvard Univ., Boston.B150 485.3 Ischemia-reperfusion induces transcriptionalactivation of brain natriuretic peptide gene via ERK1/2 in H9c2cells. Y-J. Choe, K-W. Ko, S-Y. Lee, H-J. Youn and H-S. Kim.Catholic Univ. Col. of Med., Republic of Korea.sun129

iochemistryB151 485.4 GAMT, a p53-inducible modulator of apoptosis,is critical for the adaptive response to nutrient stress. K. Chu,T. Ide, L. Brown-Endres and S.W. Lee. Massachusetts Gen.Hosp. and Harvard Med. Sch., Charlestown.B152 485.5 Salidroside inhibits clinorotation-inducedapoptosis in pulmonary microvascular endothelial cells byactivating PI3K/Akt pathway and inactivating of caspase 3. C.Kang, M. Yuan, L. Zhou, Y. Zhang and C. Liu. PLA Gen. Hosp.,Beijing and Astronaut Sci. Res. Trng. Ctr. of China, Beijing.B153 485.6 Tumor necrosis factor is necessary, but notsufficient, for castration-induced prostate regression. J.S.Davis, K.L. Nastiuk and J.J. Krolewski. Univ. of California,Irvine.B154 485.7 Oxidative stress injury to PC12 cells underglycating conditions. N. Habib and S. Mungre. NortheasternIllinois Univ.B155 485.8 Inflammatory cytokines induce oxidative stressand apoptosis in pcPC12 cells. N. Habib, G. Goswami and S.Mungre. Northeastern Illinois Univ. and Northside Col. Prep.H.S., Chicago.B156 485.9 Proanthocyanidins (Vaccinium macrocarpon)induce apoptosis in DU145 human prostate cancer cells. R.Hurta, B. Scott, K. Patel, K. Gottschall-Pass and C. Neto.Univ. of Prince Edward Island and Univ. of MassachusettsDartmouth.B157 485.10 Nitric oxide is involved in metamorphicprocesses in the anuran tadpole, Xenopus laevis. J.A. Johnson,E.E. Gardner and J. Menon. William Paterson Univ., NJ.B158 485.11 Autophagy as a survival response to sigmareceptor ligand-induced endoplasmic reticulum stress. F.J.Kim, S.M. Stabler, J.M. Schrock and G.W. Pasternak. Mem.Sloan-Kettering Cancer Ctr.B159 485.12 PGA2-induced heme oxygenase-1 expressionrequires both p38 MAPK and de novo protein synthesis inU2OS cells. K-W. Ko, Y-J. Choe, S-W. Jeong and H-S. Kim.Catholic Univ. Col. of Med., Republic of Korea.B160 485.13 Cleavage of arrestin3 by caspases preventsapoptosis via modulation of JNK-dependent cell death pathway.S. Kook, V. Gurevich and E. Gurevich. Vanderbilt Univ. Med.Ctr.B161 485.14 Filamentation protects the human fungalpathogen, Candida albicans, from programmed cell death. D.Laprade and N. Austriaco. Providence Col.B162 485.15 Cysteine rich protein 1 in UV radiation-inducedstress responses. L. Latonen, P.M. Jarvinen, U. Saarialho-Kere and M. Laiho. Univ. of Helsinki and Helsinki Univ. CentralHosp., Karolinska Inst. and Johns Hopkins Univ. Sch. of Med.B163 485.16 Nutlin-3, an MDM2 antagonist, induces Erk1/2activation in U2OS cells. S-Y. Lee, K-W. Ko, Y-J. Choe, S-W.Jeong and H-S. Kim. Catholic Univ. Col. of Med. , Republic ofKorea.B164 485.17 Effect of pathway-interconnectors in SEBinduced apoptosos related events in human PBMCs. C.Lillge, B. Klein, K. Zindel and C. Mendis. Univ. of Wisconsin-Platteville.B165 485.18 Role of Mst3 in oxidative phosphorylation. C-Y.Lin, H-Y. Wu and C-J. Yuan. Natl. Chiao Tung Univ., Taiwan.486. Biochemical PharmacologyPostersundaySu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB166 486.1 Antioxidant and cytoprotective effects ofajoene as a consequence of Nrf2-mediated glutamate-cysteineligase induction. H.Y. Kay, J.W. Yang, J.H. Ryu, R.O. Jeon andS.G. Kim. Seoul Natl. Univ. and Sookmyung Women’s Univ.,Republic of Korea.B167 486.2 Structure-activity comparison of the cytotoxicproperties of diethylmaleate and chemical analogs. J.D. Westand C.E. Stamm. Col. of Wooster.487. CaspasesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB168 487.1 Cloning and expression of a putative type IImetacaspase from Schizophyllum commune. D. Betancourtand K.M. Fox. Union Col., NY.B169 487.2 Developmental regulation of caspases duringdeath and regeneration events in an invertebrate chordate.L.D. Robison and R. Lauzon. Union Col., NY.B170 487.3 Exploring caspase specificity with a physicalthree-dimensional model. Galileo SMART Team, S. Colton,T. Herman, K. Giles, B. Koo, S. Jeske, E. Crawford andS. DeBella. Galileo Acad. of Sci. & Technol., San Francisco,Milwaukee Sch. of Engin. and UCSF.B171 487.4 Preliminary screening of capsaicin-basedcompounds as potential therapeutic targets for human nonsmallcell lung cancer. C. Weidman, M.A. Wallert and J.J.Provost. Minnesota State Univ. Moorhead.B172 487.5 Cloning and expression of a type I metacaspasefrom Schizophyllum commune. H. Zheng and K.M. Fox. UnionCol., NY.488. Making Sense of Whole Genome DataPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB173 488.1 Unbiased functional annotation of the humanregulatome. R. Mrowka, P.B. Persson and N. Blüthgen.Charité, Berlin.489. Signaling in Disease and TherapyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB174 489.1 Advanced glycation end products activateMMP-9 secretion in macrophage cells, the involvement of MAPkinase and NF-kB signaling pathways. G. Banker, F. Zhang,K.C. Kent and B. Liu. Univ. of Wisconsin-Madison.130

sundayB175 489.2 Functional roles of the AMP-activated proteinkinase in Huntington’s disease. Y. Chern and T-C. Ju. Inst. ofBiomed. Sci., Taipei.B176 489.3 The flavones induce breast cancer cellapoptosis via activation FOXO3a. C-H. Lin and L. Wan. Natl.Tsing Hua Univ. and China Med. Univ., Taiwan.B177 489.4 Heat shock protein 90 inhibitors exhibit antiinflammatoryresponse and differential cytoprotection patternfrom oxidative stress-induced injury. R. Kacimi and M. Yenari.UCSF.B178 489.5 The effect of bee venom against glutamatetoxicity in microglial cells. S.M. Lee and E.J. Yang. Korea Inst.of Oriental Med., Daejeon.B179 489.6 The involvement of WNT signaling pathway inhuman colon cancer metastasis. Q. Li and H. Chen. Univ. ofIllinois at Urbana-Champaign.B180 489.7 Signaling through the Aspergillus nidulansorthologue of PKC mediates septum formation. E. Ogburn,T.W. Hill, L. Jackson-Hayes, D.M. Loprete, B. Chavez, C.Groover and M. Pluta. Rhodes Col., TN.B181 489.8 Molecular pathways involved in RAGE mediatedattenuation of arteriogenesis. J.K. Rogers, J. Jones, R. Waikeland P. Anaya. Eastern Kentucky Univ. and Univ. of Kentucky.B182 489.9 Non-structural proteins of respiratory syncytialvirus target multiple components of the interferon induction andresponse pathways of innate immunity. S.F. Swedan and S.Barik. Univ. of South Alabama.B183 489.10 Targeting NF-kB in macrophages alleviatesskin inflammation in a mouse model of psoriasis. T. Syrovets,H. Wang, B. Buechele, O. Lunov, K. Scharffetter-Kochanekand T. Simmet. Ulm Univ., Germany.B184 489.11 Glycogen-synthase kinase-3beta/beta-cateninaxis promotes myocardial angiogenesis: role of VEGF. M.Thirunavukkarasu and N. Maulik. Univ. of Connecticut Med.Ctr.490. ToxinsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:20 p m-1:30 p mB185 490.1 Gene expression profile of staphylococcalenterotoxin B and lipopolysaccaride-induced human PBMCs.J. Bandle, S. Hildebrandt, M. Jett and C. Mendis. Univ. ofWisconsin-Platteville and Walter Reed Army Inst. of Res.B186 490.2 Design development and application of afluorescent probe to study changes in hERG channel densityand trafficking; a mechanistic basis for cardiac arrhythmia. Z.L.Bergeron, A. Collier, T. Cummins and J-P. Bingham. Univ.of Hawaii at Manoa, John A. Burns Sch. of Med., Honolulu,Indiana Univ. Sch. of Med. and Univ. of Hawaii.B187 490.3 Reversible negative design destabilization ofhemolysin A. A. DeVilbiss and T. Weaver. Univ. Wisconsin-LaCrosse.B188 490.4 Truncated beta-helices maintain templateassistedhemolysis. D. Laurent and T. Weaver. Univ. ofWisconsin-La Crosse.B189 490.5 Role of fluorine in distortion from planarity ofpolycyclic aromatic hydrocarbons. D. Liebowitz, F. Caruso, B.Zajc and M. Rossi. Vassar Col., CNR, Rome and City Col.,CUNY.BiochemistryB190 490.6 Negative design at the carboxy-terminal betaedgeof truncated hemolysin A. J. Mahoney and T. Weaver.Univ. of Wisconsin -La Crosse.B191 490.7 The cytotoxic A1 domain of shiga-like toxin1 interacts with two distinct sites on the ribosomal stalk. A.J.McCluskey and J. Gariepy. Univ. of Toronto.B192 490.8 Negative design inhibition of template-assistedhemolysis. T.M. Weaver. Univ. Wisconsin-La Crosse.491. DNA Synthesis and MutagenesisPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB193 491.1 Polymerase delta and epsilon proofreadingcooperate with MMR to suppress lethal mutations and cancerin mice. T.M. Albertson, L.E. Hays, J.M. Bugni, M. Ogawa,P.M. Treuting, R.E. Goldsby and B.D. Preston. Univ. ofWashington, Oregon Hlth. & Sci. Univ., UCLA and UCSF.B194 491.2 Insertion/deletion polymorphism of theangiotensin converting enzyme gene and breast cancer risk.N.K. Javaid, H. Fathima, G. Abdulla, A.S. Al-Ammari andF.A. Abbasi. Dubai Med. Col., United Arab Emirates.B195 491.3 Analysis of ciprofloxacin induced evolutionarychanges in E. coli. E. Santos, O. Khalpari, T. Holden and N.Gadura. Queensborough Community Col. and Queens Col.,CUNY.B196 491.4 Inhibition of nucleosome assembly by themismatch repair system. T. Takahashi, K. Taki, T. Higashi, T.Nakagawa and H. Masukata. Grad. Sch. of Sci., Osaka Univ.492. DNA TransactionsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB197 492.1 Acetylation of Dna2 and FEN1 by p300promotes long flaps favoring DNA stability. L. Balakrishnan,J.A. Stewart, P. Polaczek, J.L. Campbell and R.A. Bambara.Univ. of Rochester and Caltech.B198 492.2 The DNA damage inducible protein UmuDinhibits replication. P.J. Beuning, J. Sefcikova, J. Fang, J.R.Engen and M.C. Silva. Northeastern Univ.B199 492.3 SV40 large T antigen helicase/initiatorstructure and function. X. Chen and D. Gai. Univ. of SouthernCalifornia.B200 492.4 MAP kinase-mediated regulation of DNAreplication origin licensing and Cdt1 stability. J.G. Cook, S.Chandrasekaran and T.X. Tan. Univ. of North Carolina atChapel Hill.B201 492.5 Defects in DNA ligase I trigger PCNAubiquitination at lysine 107. S. Das-Bradoo, H.D. Nguyen, R.M.Ricke, J.C. Haworth and A-K. Bielinsky. Univ. of Minnesota,Minneapolis and Mayo Clin.B202 492.6 Expression profiling of cellular transformationinduced by tumor-associated DNA polymerase beta variantI260M. K.A. Donigan and J. Sweasy. Yale Univ.B203 492.7 A unique DNA binding mode enables humanmterf1 to regulate mitochondrial transcription. M. Garcia-Diaz,E. Yakubovskaya and E. Mejia. Stony Brook Univ.sun131

iochemistryB204 492.8 Translesion synthesis of abasic sites by yeastDNA polymerase epsilon. E. Johansson and N. Sabouri.Umeå Univ., Sweden and Princeton Univ.B205 492.9 Replication-dependent interactions of RECQ4with MCM holocomplex. Y. Liu. Yale Univ. Sch. of Med.B206 492.10 Interactions of human mismatch repair proteinsMutSa and MutLa with proteins of the ATR-Chk1 pathway. Y.Liu, Y. Fang, H. Shao, L. Lindsey-Boltz, A. Sancar and P.Modrich. Duke Univ. Med. Ctr. and Univ. of North Carolina Sch.of Med.B207 492.11 Subunit exchange and DNAinding dynamicsof Escherichia coli single-stranded DNA binding protein. C.E.Mason, S. Jergic, N. Dixon and J. Beck. Sch. of Chem., Univ.of Wollongong, Australia.B208 492.12 Herpes simplex virus type 1 infection disruptsthe ATR-mediated damage response. K.N. Mohni and S.K.Weller. Univ. of Connecticut Hlth. Ctr.B209 492.13 The transcriptional factor, DACH1, functionsas tumor suppressor by antagonizing FOX protein signaling. J.Zhou, K. Wu, M.C. Casimiro, V.M. Popov, R.G. Pestell and C.Wang. Thomas Jefferson Univ.493. Non-coding RNAsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB210 493.1 MYC is a target for microRNA -33b. A.A.L.Agha and Y. Li. Univ. of Louisville.B211 493.2 The large, noncoding OLE RNA is associatedwith membrane biochemistry. K.F. Block, J. Wallace, E. Puerta-Fernandez and R. Breaker. Yale Univ. and HHMI.B212 493.3 Characterizing sex differences in miRNAexpression in left ventricular hypertrophy in mice. J.O. Davidson,D. VanderPloeg and R.L. Waikel. Eastern Kentucky Univ.B213 493.4 Mechanism of downregulation of RNApolymerase III-transcribed ncRNA genes in macrophages byLeishmania. T. Rana, S. Misra, M.K. Mittal, A.L. Farrow andG. Chaudhuri. Meharry Med. Col.B214 493.5 Nuclear pore complex and epigenetic regulatorproteins share conserved domains for interaction with functionalnon-coding ncRNA. J.E. Wissler. ARCONS Inst. for AppliedRes. & Didactics, Bad Nauheim, Germany.B215 493.6 miR181 regulates Mcl-1 expression in Lyndependentimatinib-resistant CML. E. Zimmerman, C.M.Dollins, S.M. Hammond and L.M. Graves. Univ. of NorthCarolina at Chapel Hill.494. Posttranscriptional Gene RegulationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB216 494.1 Elucidating the regulation and dynamics ofO-GlcNAc during signal transduction. L.D. Carrillo and L.K.Mahal. Univ. of Texas at Austin and NYU.B217 494.2 Cold-inducible RNA binding protein modulatesproliferation in the mouse mammary epithelium. R.S. Hartley,T. Mitchell, X. Guo, Y. Wu, Y. Brandt and H.J. Hathaway. Univ.of New Mexico Hlth. Sci. Ctr.sundayB218 494.3 Post-transcriptional control of humaninterleukin-3 mediated by its 3’-UTR. M. Hernández-Pérez, N.Almodov, J.A. Gonzalez-Feliciano and C. Gonzalez. Univ. ofPuerto Rico Med. Sci. Campus and Rio Piedras Campus.B219 494.4 Identification of a translational control elementinvolved in KLF4 posttranscriptional regulation. C-C. Lin andJ.M. Ruppert. West Virginia Univ.B220 494.5 The novel gene C17orf37 is regulated at bothtranscriptional and post-transcriptional levels. S. Rajendiran,S. Dasgupta and J. Vishwanatha. Univ. of North Texas Hlth.Sci. Ctr. at Fort Worth.B221 494.6 Post-transcriptional regulation of geneexpression in response to iron deficiency in S. cerevisiae. S.V.Vergara and D.J. Thiele. Duke Univ. Med. Ctr.B222 494.7 Role of RNA-binding protein HuR and CUGBP1in LPS-induced interleukin-6 expression in macrophages. W.Zha, G. Wang, B.S. Pecora, E. Studer, P.B. Hylemon, W.M.Pandak and H. Zhou. Virginia Commonwealth Univ., ChinaPharmaceut. Univ. and McGuire VA Med. Ctr., Richmond.495. RiboregulationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB223 495.1 Engineering mRNA structural regulation oftranscription using an RNA-sensing riboregulator. J.B. Lucks,L.S. Qi, V. Mutalik and A.P. Arkin. Univ. of California, Berkeley,Joint Bioenergy Inst., Emeryville and Lawrence Berkeley Natl.Lab.496. RiboswitchesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB224 496.1 Identification and characterization of a thiaminepyrophosphate riboswitch in Mycobacterium tuberculosis: anew drug target in tuberculosis drug design. S. Mitra and F.Aboul-ela. LSU.497. RNA Editing and ModificationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB225 497.1 Alternative editing of cytochrome c oxidaseIII mRNA in trypanosome mitochondria generates proteindiversity. S.E. Sykes and S.L. Hajduk. Univ. of Georgia.B226 497.2 Non-coding ncRNA modified by environmentalfactors and the epigenetic code: translating the entangledcancer-angiogenesis-tolerance epigenome. J.H. Wissler.ARCONS Inst. for Applied Res. & Didactics, Bad Nauheim,Germany.132

sunday498. RNA TurnoverPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB227 498.1 Poly(A)-specific ribonuclease: molecularmechanisms of mRNA cap and poly(A) tail recognition. A.Virtanen, N. Henriksson, P. Nilsson, M. Wu and H. Song.Uppsala Univ., Sweden and Inst. of Molec. and Cell Biol.,Singapore.B228 498.2 A microRNA upregulates neuron-specifictranscripts through the NMD pathway. M.F. Wilkinson, L.Huang, A.D. Bhalla, A. Bhardwaj, H-W. Song, R. Karam andI.G. Bruno. UCSD and Univ. of Texas M.D. Anderson CancerCtr.499. RNA-Protein InteractionsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB229 499.1 Structural studies of an RNA aptamer with highaffinity for the B. anthracis ribosomal protein S8. M.G. Davlieva,J. Doneske, M. Michnicka, E.P. Nikonowicz and Y. Shamoo.Rice Univ. and Central Sci. Lab., Sand Hutton, U.K.B230 499.2 Systematic studies on the recognition of 3’-endmethylated small silencing RNAs by PAZ domains. L. Ding, Y.Huang, Y. Tian, D.J. Patel and J-B. Ma. Univ. of Alabama atBirmingham and Mem. Sloan-Kettering Cancer Ctr.B231 499.3 Effects of viral genome-linked protein ondepurination of viral RNA by pokeweed antiviral protein. A.Domashevskiy, D.E. Friedland and D.J. Goss. Hunter Col.and John Jay Col., CUNY.B232 499.4 Pokeweed antiviral protein exhibits variablebinding affinity to uncapped mRNA with differing structuralelements. D.E. Friedland, J. DeGrazia and A. Toney. John JayCol., CUNY.B233 499.5 Global identification of the gene-specificassociation of the exon-exon junction complex in Drosophila.N. Haque and M. Blanchette. Stowers Inst. for Med. Res. andUniv. of Kansas Sch. of Med.B234 499.6 Structural insights into mechanisms of thesmall RNA methyltransferase HEN1. Y. Huang, L. Ji, Q.Huang, D. Vassylyev, X. Chen and J-B. Ma. Univ. of Alabamaat Birmingham and Univ. of California, Riverside.B235 499.7 Kinetic analysis of iron responsive elementmRNA with iron regulatory protein (IRP1). M.A. Khan, W.E.Walden, E.C. Theil and D.J. Goss. Hunter Col., CUNY, Univ. ofIllinois, Chicago, Children’s Hosp. Oakland Res. Inst. and Univ.of California, Berkeley.B236 499.8 Biophysical characterization of features ofRNA helicase A that confer translational control of retroviraland selected cellular mRNAs. A.K. Ranji, M. Kvaratskheliaand K.A. Boris-Lawrie. Ohio State Univ.B237 499.9 How HIV-1 Rev gets its groove on. G SMARTteam, S. Colton, T. Herman, K. Giles, B. Koo, S. Jeske, J.Fernandes and S. DeBella. Galileo Acad. of Sci. & Technol.,San Francisco, Milwaukee Sch. of Engin. and UCSF.BiochemistryB238 499.10 Biophysical characterization of effect of zincon eukaryotic translation initiation factor 4B. S. Sultana, D.R.Gallie and D.J. Goss. Hunter Col. and Grad. Ctr., CUNY andUniv. of California, Riverside.B239 499.11 Identifying IRES RNA-protein complexes bySILAC-based mass spectrometry. B.P. Tsai, X. Wang, L. Huangand M.L. Waterman. Univ. of California, Irvine.B240 499.12 Dynamics of the tRNase Z flexible arm. C.Wilson, L. Levinger, E. Chang, N. Lama, M. Sabry, R. Raiand S. Paul. York Col., CUNY.B241 499.13 Mouse lipocalin-2 aptamer: an RNA probefor molecular discrimination. L. Zhai, T. Wang and M. Nilsen-Hamilton. Iowa State Univ.500. Small RNAsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB242 500.1 microRNAs associated with environmentalstress in Arabidopsis. R.S.H. Brown, D-H. Jeong, B.C. Meyersand P.J. Green. Univ. of Delaware and Delaware Biotechnol.Inst.B243 500.2 Thermodynamics of small symmetrical internalloops in RNA: sequence, pH and ion effects. S.K. Furniss andN. Grover. Colorado Col.B244 500.3 Thermodynamic examination of conservedsequences of TAR RNA in HIV-1. P.L. Hannan, G. Kresheckand N. Grover. Colorado Col. and Univ. of Colorado at ColoradoSprings.B245 500.4 Thermodynamic stablity and divalent ioninteractions of RNA containing purine-rich bulges. S.F. Stromand N. Grover. Colorado Col.501. Viral RNAs and Virus StructurePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB246 501.1 Modification of the pH-dependent functionof the HMPV F protein. B. Hackett and R. Dutch. Univ. ofKentucky Col. of Med.B247 501.2 Conversion of adenines to inosines in RNAduring virus infections activates innate immune responses.J-Y. Liao, C. Prater, S.A. Thakur and F. Imani. NIEHS, NIH,Research Triangle Park.502. Genetic and Metabolic Approaches toObesityPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB248 502.1 Association between 5-HT receptor genepromoter polymorphism and obesity. N.S.E.D. Hemimi, M.M.Abd El Salam, M.M. Khalil and H.M.G.E.D. Ahmad. AinShams Univ. and Zagazig Univ., Egypt and King Abdull AzizUniv., Saudi Arabia.sun133

iochemistryB249 502.2 Adipose tissue responses to binge andrestrictive eating in ground squirrels. B.M. Kohlnhofer, S.T.Cooper and M.A. Maher. Univ. of Wisconsin-La Crosse.B250 502.3 Chronic b3 adrenergic stimulation inducedremodeling of white adipose tissue in mice. C.R. Lindholm,J.D. Bauwens, R.L. Ertel, J.D. Mulligan, E.G. Schmuck andK.W. Saupe. Univ. of Wisconsin-Madison.503. Metabolism and CancerPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB251 503.1 Fatty acid suppression of cell proliferation isassociated with the inhibition of polyisoprenylated methylatedprotein methyl esterase. F. Aamissah, S. Taylor, R. Duvernaand N.S. Lamango. Col. of Pharm. and Pharmaceut. Sci.,Florida A&M Univ.B252 503.2 Cyclin D1 regulates hepatic lipid metabolism.E.A. Hanse, L.K. Mullany, M. Mashek, D.G. Mashek and J.H.Albrecht. Hennepin County Med. Ctr., Minneapolis and Univ.of Minnesota, St. Paul.B253 503.3 Indole-3-acetic acid/horseradish peroxidaseinduces apoptosis in TCCSUP human urinary bladdercarcinoma cells. Y.M. Jeong, S.Y. Kim, H. Li, H-Y. Yun, K.J.Baek, N.S. Kwon, W.Y. Kim and D-S. Kim. Chung-Ang Univ.,Republic of Korea.B254 503.4 The electrode-electrolyte impedancespectroscopy measurements of cancer cell culture media andKCl while calibrating a system throughout a frequency range.C. Richardson, S. Bhansali and G. Vuppala. Medgar EversCol., CUNY and Univ. of South Florida.B255 503.5 High glucose inhibits p53 function via Thr55phosphorylation. Y. Wu, J. Lin, L.G. Piluso and X. Liu. Univ. ofCalifornia, Riverside.B256 503.6 Modification of the adiponectin:leptin ratio mayunderlie obesity-dependent prostate cancer progression. J.A.Zeppieri and M.K. Connor. York Univ., Canada.504. MetabolomicsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB257 504.1 Metabolic profiling a drug subsisting Gramnegativebacteria. K.W. Armstrong , K.A. Faria, J.L. Rodriquez,R. Benner, M.E. Allen and A.J. Piefer. Hartwick Col., NY.B258 504.2 Metabolomic analysis of the hepatocyte nuclearfactor 1 alpha knockout mouse. J.A. Bonzo, A.D. Patterson,K.W. Krausz and F.J. Gonzalez. NCI and NIGMS, NIH.B259 504.3 LC-FTMS-based metabolomics reveals ageandgender-related differences in marmosets. Q.A. Soltow,D.E.L. Promislow, K.G. Mansfield, L.M. Wachtman andD.P. Jones. Emory Univ., Univ. of Georgia and New EnglandPrimate Res. Ctr., Harvard Med. Sch.B260 504.4 Partial beta-oxidation and bilateral alphaoxidationof gamma-hydroxybutyrate in perfused rat livers. G-F.Zhang, S. Sadhukhan, Y. Han, K.A. Tomcik, A.M. Murphy, S.Barnoff, G. Tochtrop and H. Brunengraber. Case WesternReserve Univ.sunday505. Quantitative Metabolomics and DiseasePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB261 505.1 Metabolomic evaluation of masseter muscle inan experimental malocclusion model. R. Farinha, M. Gomes,L. Tavares, R. Carvalho and A.M.S. Cabrita. Univ. of Coimbra,Portugal.506. Cargo Sorting and Vesicle TargetingPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB262 506.1 In search for an appropriate model to studythe role of MYO5B in apical membrane protein trafficking.K. Mackovicova, A.T. van der Goot, K.A. Sjollema, E.A.A.Nollen and S.C.D. van Ijzendoorn. Univ. Med. Ctr. and Univ.of Groningen, Netherlands.B263 506.2 ERK and p38 MAPK regulate chaperonemediatedperoxiredoxin 6 targeting to lysosomal organelles inlung epithelial cells. E.M. Sorokina, S.I. Feinstein and A.B.Fisher. Univ. of Pennsylvania.507. Cell DivisionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB264 507.1 Association of the anillin-related protein Mid1with actin. J.L. Jakubowski and D.M. Clifford Hart. GrandValley State Univ.B265 507.2 Rapamycin-sensitive co-localization of mTORto the mitotic spindle. J.S. Shenberger and L. Zhang. PennState Col. of Med.B266 507.3 Bardet-Biedl sydrome proteins play a rolein centrosome amplification. M.G. Teixeira, Q. Zhang, V.C.Sheffield and D.L. Kooyman. Brigham Young Univ. and Univ.of Iowa.508. Intracellular DynamicsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB267 508.1 Parallel increasing of a7 and b1 integrinprevents muscular dystrophy in mdx mice. J. Liu and S.J.Kaufman. UCSF and Univ. of Illinois, Urbana.134

sundayBiochemistry509. Membrane BiogenesisPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB268 509.1 Discovery, characterization, and structuraldetermination of a novel UDP-2,3-diacylglucosamine hydrolase.L.E. Metzger, J.K. Lee, R.M. Stroud and C.R.H. Raetz. DukeUniv. and UCSF.B269 509.2 The endoplasmic reticulum protein Orm2 isrequired for cold adaptation in Saccharomyces cerevisiae. J.W.Zhong and J. Loertscher. Seattle Univ.510. Mitochondrial DynamicsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB270 510.1 Intracellular growth of Toxoplasma gondiirequires association with respiration-competent mitochondria.J.F. Andrews and S. Barik. Univ. of South Alabama Col. ofMed.B271 510.2 Hydrogen peroxide effects upon viabilityand oxygen consumption by Kluyveromyces marxianus andSaccharomyces cerevisiae wild yeast. M. Arellano-Plaza, R.Noriega-Cisneros, M.M. Estrada-Villagómez, M. Clemente-Guerrero, S. Manzo-Avalos, J.C. González-Hernández andA. Saavedra-Molina. Univ. Michoacana de San Nicolás deHidalgo, Mexico.B272 510.3 Lipid peroxidation induced by H 2O 2altersthe sensitivity of complex III to oxidative stress by increasingiron labile pool. C. Cortés-Rojo, M.M. Estrada-Villagómez,E. Calderón-Cortés, R. Montoya-Pérez and A. Saavedra-Molina. Univ. Michoacana de San Nicolás de Hidalgo, Mexico.B273 510.4 ChChd3, an inner mitochondrial membraneprotein is essential for maintaining cristae integrity andmitochondrial function. M. Darshi, G.A. Perkins, M.R. Mackey,S. Petrosyan, A.N. Murphy, M.H. Ellisman and S.S. Taylor.HHMI and UCSD.B274 510.5 Protein interaction and phosphorylation ofdiaphanous 1 regulate mitochondria movement in H295Rhuman adrenocortical cells. D. Li and M.B. Sewer. SkaggsSch. of Pharm. and Pharmaceut. Sci., UCSD.B275 510.6 Mechanism of ATP-dependent release of wildtype and mutant human brain hexokinases from mitochondria. N.Mehyar, M. Watanabe, L. Shen, A. Skaff and R.B. Honzatko.Iowa State Univ.B276 510.7 Oxidation- or radiation-derived effects onhuman mitochondria as seen in a fibroblast cell line derivedfrom a family known to have elevated levels of the 4977-bpcommon deletion in its mitochondrial DNA. Z. Stoll and W.Pogozelski. SUNY Geneseo.511. BioenergeticsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB277 511.1 Influence of lipoperoxidation on the generation ofmitochondrial membrane potential. M.M. Estrada-Villagómez,C. Cortés-Rojo, E. Calderón-Cortés, R. Montoya-Pérez, M.Clemente-Guerrero, S. Manzo-Avalos and A. Saavedra-Molina. Univ. Michoacana de San Nicolás de Hidalgo and Fac.of Med. Sci. and Biol. “Dr. Ignacio Chávez”, Morelia, Mexico.B278 511.2 Mechanisms of mitochondrial dysfunctioninduced by sulfur mustard in human epidermal keratinocytes.M.E. Martens. U.S. Army Med. Res. Inst. of Chem. Defense,Aberdeen Proving Ground, MD.512. Cytochrome P450PosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB279 512.1 Regulation of hepatic CYP2B enzymes:translational control via the heme-regulated inhibitor. P.Acharya and M.A. Correia. UCSF.B280 512.2 Self-sufficient catalytic system of cytochromeP450cam, putidaredoxin, and putidaredoxin reductase providesa useful cell-based enzymatic reaction. C-Y. Eun, Y-R. Lim, S.Han, H-G. Park, P.R. Ortiz de Montellan and D. Kim. KonkukUniv., Republic of Korea and UCSF.B281 512.3 Mechanism-based inhibition of humancytochrome P450 2D6 by Schering 66712. C.S. Mocny, E.J.Arthur, B.F. Butler, L.E. Diffenderfer, J.R. Palamanda, F.P.Guengerich, A.A. Nomeir and L.L. Furge. Kalamazoo Col.,Schering-Plough Res. Inst. and Vanderbilt Univ.B282 512.4 Functional expression and characterization ofCYP51 from Candida albicans. H-G. Park, S. Han, Y-R. Lim,C-Y. Eun and D. Kim. Konkuk Univ., Republic of Korea.B283 512.5 Kinetics of substrate binding to humancytochrome P450 3A4: a study with fluorol-7GA, a fluorescentallosteric ligand. J.A.O. Rumfeldt, J.R. Halpert and D.R.Davydov. Skaggs Sch. of Pharm. and Pharmaceut. Sci.,UCSD.B284 512.6 Displaced conformational equilibrium in apiezophilic cytochrome P450. E.V. Sineva, J.R. Halpert andD.R. Davydov. Skaggs Sch. of Pharm. and Pharmaceut. Sci.,UCSD.B285 512.7 Kinetic analysis of steps involved in oxidationby cytochrome P450 19A1. C.D. Sohl and F.P. Guengerich.Vanderbilt Univ.B286 512.8 Catalysis by microsomal cytochrome P450 2B4proceeds via a stable hydroperoxo intermediate identified byfreeze quench EPR. L. Waskell, N.M. Pearl, S-C. Im, R. Kunzand S.W. Ragsdale. Univ. of Michigan.sun135

iochemistry513. FlavoproteinsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB287 513.1 Determining structural differences in thedark and light states of AppA using vibrational and ultrafastfluorescence spectroscopy. A.L. Haigney, M. Kondo, A.Stelling, A. Lukacs, A. Bacher, P.J. Tonge and S. Meech.Stony Brook Univ., Sch. of Chem. Sci. and Pharm., Univ. ofEast Anglia, U.K. and Tech Univ. of Munich.B288 513.2 Mechanistic studies on UDP-galactopyranosemutases from Aspergillus fumigatus and Trypanosoma cruzi.M.L. Oppenheimer, A. Blumer, M.B. Poulin, R.F. Helm, T.L.Lowary and P. Sobrado. Virginia Tech and Univ. of Alberta.B289 513.3 Flavin-dependent N-hydroxylating enzymesfrom Mycobacterium smegmatis and Aspergillus fumigatus. P.Sobrado, W. Chocklett and R. Robinson. Virginia Tech.B290 513.4 Expression, purification, and characterizationof a new sulfhydryl oxidase from Trypanosoma brucei. A. Styer,V. Kodali, V. Daithankar and C. Thorpe. Univ. of Delaware.514. Cell CyclePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB291 514.1 CyclinB/cdk1-mediated phosphorylation of thePR-Set7 histone methyltransferase is required for its nuclearlocalization and stability during mitosis. S. Wu and J.C. Rice.Univ. of Southern California.515. Cell Cycle and Growth ControlPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB292 515.1 Global protein synthesis and hypoxia responsesin yeast. D. Cadinu, A.N. Shah, R. Ghosh Dastidar, R.M.Henke and L. Zhang. Univ. of Texas at Dallas.B293 515.2 Kinase activity-independent regulation of GRKin zebrafish early development. X. Jiang, P. Yang and L. Ma.Fudan Univ., People’s Republic of China.B294 515.3 Liver regeneration after partial hepatectomyis regulated by a change in sulfur-containing substancemetabolomics in rats. S.J. Kim, Y.S. Jung and Y.C. Kim. Col. ofPharm., Seoul Natl. Univ.B295 515.4 Acetylbritannilactone inhibits smooth musclecell proliferation through suppression of cell cycle progression,ERK1/2 activation, and induction of apoptosis. B. Liu, M. Han,R-h. Sun, J-j. Wang, Y-p. Liu and J-k. Wen. Hebei Med. Univ.,People’s Republic of China.B296 515.5 Nuclear-mediated function of Chmp1A in theregulation of ATM signaling activity for the control of humanpancreatic tumor cell growth. S. Manohar, M. Harlow, C.R.Mackie, J. Li and M. Park. Marshall Univ. and West VirginiaState Univ.sundayB297 515.6 Pasteurella multocida toxin activates mTORC1and induces cell spreading in Swiss 3T3 cells. H. Oubrahim,B. Wilson and P.B. Chock. NHLBI, NIH and Univ. of Illinois atUrbana-Champaign.516. Cyclins and Cyclin-Dependent KinasesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB298 516.1 Cyclic AMP-independent phosphoregulationof protein kinase A in the fission yeast, Schizosaccharomycespombe. B. McInnis and S. Marcus. Univ. of Alabama.517. Fluorescence Microscopy Approachesto Understand ApoptosisPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB299 517.1 Creation of cell models from confocalmicroscopy data files using rapid prototyping. V. Paliwal, J.Konieczny, K. Eliceiri and I. Reifschneider. Milwaukee Sch. ofEngin., Ferris State Univ., MI and Univ. of Wisconsin-Madison.518. Functional Proteomic StudiesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB300 518.1 Mapping domains of anti-apoptotic Bcl-xLrequired for interaction with cell cycle check point regulatorAven. E. Datan, B. Roelofs and J.M. Hardwick. Johns HopkinsUniv. and Queens Col., CUNY.B301 518.2 Paneth cell a-defensin polymorphisms inC57Bl/6 mice and identification of vestigial myeloid a-defensingenes in the mouse genome. A.J. Ouellette, H. Tanabe andM.T. Shanahan. USC Keck Sch. of Med., Ministry of Health,Labour and Welfare, Tokyo and Univ. of North Carolina Sch. ofMed.B302 518.3 Guilt by association: functional annotationof TM0486 from Thermotoga maritima by identification of itsbound ligands. B.A. Palanski and M.J. Snider. Col. of Wooster,OH.B303 518.4 Proteomic identification of hemolymph proteinsinvolved in early stages of immune response in the insectManduca sexta. E.J. Ragan and M.R. Kanost. Kansas StateUniv.136

sundayBiochemistry519. Mass SpectroscopyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB304 519.1 A rapid method for removal of detergents fromproteins and protein digests in a spin column format. B.S.Antharavally, A.M. Salunkhe, K.A. Mallia, M.M. Rosenblatt,J.C. Rogers, N.R. Haghdoost, P.J. Haney, B. Benton andP.A. Bell. Thermo Fisher Scientific, Rockford, IL.B305 519.2 Mass spectral analysis of mutant and wild-typeselenomethionyl-dihydrofolate reductase. J.O. Boles, K.M.Broderick and K.M. Broderick. Tennessee Technol. Univ.520. NanotechnologyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB306 520.1 Molecular mechanism of nanodiamondsattacking cancer cell. H-W. Chen, T-M. Cheng, H-L. Chuand C-C. Chang. Natl. Chiao Tung Univ., Taiwan and Inst. ofPhysics, Acad. Sinica, Taipei.B307 520.2 Methotrexate encapsulated in PLGAmicroparticles conjugates with biotin as drug delivery systemfor cancer cells from domestic animals. A.J. Gomes, N.A.Oliveira, T.J.S. Alves, M.S.T. Rocha and R.B. Azevedo. Univ.of Brasilia.B308 520.3 A role for c-Jun N-terminal kinases in apoptosistriggered in human macrophages by carboxydextran-coatedsuperparamagnetic iron oxide nanoparticles. O. Lunov,T. Syrovets, B. Buechele, K. Tron, G.U. Nienhaus and T.Simmet. Ulm Univ. and Karlsruhe Univ., Germany.B309 520.4 Covalent immobilization of carbonic anhydraseinto mesoporous silica nanoparticles for drug deliveryapplications. J. Mendez and K. Griebenow. Univ. of PuertoRico.B310 520.5 Targeted nanoparticle delivery of tumorsuppressing UDP-glucuronosyltransferase genes into cancercells. A. Radominska-Pandya, A. Karmakar, S.M. Bratton, X.Yang, M.W. Mahmood, A.E. Gallus-Zawada and A.S. Biris.Univ. of Arkansas for Med. Sci. and Univ. of Arkansas at LittleRock.B311 520.6 Beta-1,3-D-glucan nanoparticle mediateddelivery of siRNAs to professional phagocytes for inhibitingleishmania infection. T. Rana, E. Chaudhuri and G. Chaudhuri.Meharry Med. Col.B312 520.7 Endocytosis of pro-apoptotic twin-baseRGDSK helical rosette nanotubes in human U937 macrophagecell line. S. Singh , H. Fenniri, U. Hemraz and B. Singh. Univ.of Saskatchewan and Univ. of Alberta.B313 520.8 Formulation and characterization of antibodycoated poly(lactic-co-glycolic acid) nanoparticles to targetmetastatic cancer. S.I. Thamake, A. Ranjan, S.L. Raut, Z.Gryczynski and J.K. Vishwanatha. Univ. of North Texas Hlth.Sci. Ctr.B314 520.9 Unraveling Spiderman’s glue silk. C.A.Vierra, Y. Hsia, P. Geurts, L. Zhao, T. Tuton-Blasingame, E.Blasingame and C. La Mattina. Univ. of Pacific.521. Protein ChemistryPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB315 521.1 ERK3-MK5 regulates interstitial fibrosis duringpressure-overload hypertrophy. D.D. Dingar, M-A. Gillis, Y. Shi,J-C. Tardif, M. Gaestel and B.G. Allen. Montreal Heart Inst.,Univ. of Montreal and Med. Sch Hannover, Germany.B316 521.2 Proximity of proregion anionic residues tothe mature region maintains proCryptdin-4 inhibition. S.M.Figueredo, J.E. Gable, J.E. Kim and A.J. Ouellette. Univ. ofCalifornia, Irvine, UCSD and USC Keck Sch. of Med.B317 521.3 Inherently antibacterial hydrogels: alteringactivity via tryptophan/arginine interactions. T.J. Larsen, D.Salick, R. Nagarkar and J. Schneider. Univ. of Delaware.B318 521.4 A sensitive fluorimetric assay for quantifyingmaleimide groups in biopolymers. J. Liao, X. Han and Z. Diwu.ABD Bioquest Inc., Sunnyvale, CA.B319 521.5 Characterizing Y532H disease-causingmutation and N-terminal domains of the human Wilson protein.J. Muia, D. Huffman, L. Banci, I. Bertini and S. Wang.Western Michigan Univ., Univ. of Florence and Univ. of Guelph,Canada.B320 521.6 Divergence in proteins: study of cytochromeb5 isoforms using core-swap mutants. S. Parthasarathy, K.Kuczera and D.R. Benson. Univ. of Kansas.B321 521.7 Electrochemical and spectroscopic studiesof stellacyanin of Japanese lacquer tree sap from Oku-kuji,Japan. R. Takahashi, H. Terakado and T. Kohzuma. IbarakiUniv. and Ibaraki Prefect. Technol. Ctr., Japan.522. Protein Profiling in Normal andDisease StatesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB322 522.1 Development of an ELISA-based screeningassay for the selection of a-synuclein phosphorylationmodulators. A. Arteaga, M. Luzardo and L. Segatori. Univ. ofTexas at El Paso and Rice Univ.B323 522.2 Proteomic profiling of unnatural amino acidtoxicity through differential expression of wild type versustelluroproteins in Eschericia coli DL41(DE3). S.C. Brinkleyand J.O. Boles. Tennessee Tech Univ.B324 522.3 Divalent interaction between HPS1 and HPS4to form the biogenesis of lysosome-related organelles 3(BLOC-3). C. Carmona-Rivera, J.S. Bonifacino, W.A. Gahland C.L. Cadilla. NHGRI and NICHD, NIH and Univ. of PuertoRico, Sch. of Med.B325 522.4 Polymorphisms in UEA-1 lectin binding tohuman buccal cells and salivary fluid. O.A. Vanderpuye.Albany State Univ.sun137

iochemistry523. Quantitative Proteomic Analysis ofProtein ComplexesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB326 523.1 Decoding proline-rich sequence recognition byepitope-based proteomics. C. Freund, M. Kofler, A. Schlundt,D. Kosslick, J. Sticht, M. Schuemann and E. Krause. FreeUniv. Berlin and Mount Sinai Hosp., Ontario.B327 523.2 Quantitative interactome analysis of RGS9-2degradation mechanisms in mammalian brain. E. Posokhova,V.N. Uversky and K.A. Martemyanov. Univ. of Minnesota,Minneapolis and Indiana Univ. Sch. of Med.524. Biosynthesis of Complex MoleculesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB328 524.1 Production of recombinant dengue virus-likeparticles by COS-1 cells in a serum-free defined medium.M.H. Simonian, M. Nair, L. Jacky and G-J. Chang. FocusDiagnositics Inc., Cypress, CA and Ctrs. for Dis. Control andPrevent., Fort Collins.525. Chemical Probes and Their Use inIdentifying New Therapeutic TargetsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB329 525.1 Endocytic nanodiamond for the labeling andtracking of cancer cells. J-I. Chao and K-K. Liu. Natl. ChiaoTung Univ., Taiwan.B330 525.2 Dabcyl /fluorescein-based probes for detectionof thiols and disulfides: proteomic application to discovery ofreactive disulfides in live cells. T. Jonhera, P.K. Pullela, W.T.Bassam, M.J. Carvan III and D.S. Sem. Marquette Univ.,Bigtec Labs, Bangalore, Med. Col. of Wisconsin and Univ. ofWisconsin-Milwaukee.526. Chemistry and Cell Biology of NaturalProductsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB331 526.1 Scorpion venom peptide accelerating theproliferation of irradiated M-NFS-60 cells. W. Dong, Y. Qiu andT. Kong. Guangzhou Med. Univ., People’s Republic of China.B332 526.2 Antibacterial activity of Co(II) complexes withsome heterocyclic compounds. S.R. Govori, N. Ajvazi, A.Buza, A. Haziri and A. Rifati. Univ. of Prishtina, Kosovo.B333 526.3 Microbiological evaluation of 3-((E)-(4-chloro-6-hydroxypyrimidin-2-ylimino)methyl)-4-chloro-2H-chromen-2-one. S.R. Govori, S. Spahiu, A. Haziri, M. Daci, M. Sehabiand K. Kurteshi. Univ. of Prishtina, Kosovo and State Univ. ofTetovo, Macedonia.B334 526.4 Antioxidant and anti-inflammatory effects ofblack rasperries in a dextran sodium sulfate model of colitis.N.A. Horelik, D.C. Montrose, J. Madigan, D. Pleau, D.W.Rosenberg and G.D. Stoner. Univ. of Connecticut Hlth. Ctr.,Saint Joseph Col., CT and Ohio State Univ. Col. of Med.B335 526.5 Analysis of aromatic analogs on cellproliferation of CRL2338, CRL2351, and CRL2315 expressingcombinations of Her2/Neu receptor and ER and PR receptors.H.T. Le and N. Hopkins. Tulane Univ.B336 526.6 Cytotoxicity screening of fungal endophytesusing metastatic Met-1 cells. K-S.S. Lee, L. Adelzadeh, M.Lloyd, C. Sweeney, J.D. Adams and A.T.W. Cheung. Univ.of California Davis, Sacramento, MIT and Univ. of SouthernCalifornia.B337 526.7 Synthesis of totarol analogs for inhibitionof FtsZ. F.U. Rutaganira, M.B. Kim and J.T. Shaw. Univ. ofCalifornia, Davis, Unversity of California and Davis.B338 526.8 Myricetin inhibits Akt survival signaling andinduces Bad-mediated apoptosis in a low dose ultraviolet-BirradiatedHaCat human immortalized keratinocytes. H.J. Yang,W. Kim, H. Youn, Y.J. Yun, K.M. Seong and B. Youn. PusanNatl. Univ., Sejong Univ., Republic of Korea and Korea Hydro &Nuclear Power Co., Ltd., Seoul.B339 526.9 Synthesis and the biological evaluation ofarylnaphthalene lignans as anti-hepatitis B virus agents. S.F.Yeh, C.H. Lin, D. Janmanchi and Y.P. Tseng. Natl. Yang-MingUniv., Taiwan and Inst. of Chem., Acad. Sinica, Taipei.527. Mechanisms of Drug ActionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p msundayB340 527.1 SRF, a novel anti-cancer drug, inhibitsmicrotubule polymerization and dynamics and induceshyperphosphorylation of Bcl-2 in cancer cells. B-H. Choi, L.Feng, H. Amaravadhi, N. Bharatham, R. Prakash and H.P.Yoon. Nanyang Technol. Univ., Singapore.B341 527.2 Superior efficacy of phosphoplatins: novelnon-DNA-binding platinum drugs for human ovarian cancer. S.Moghaddas, P. Majmudar and R.N. Bose. Ohio Univ. Col. ofOsteo. Med.B342 527.3 Determination of the drug binding site withinintegrin CD11b/CD18. K. Rands, D. Stoub and V. Gupta.Rollins Col., FL and Univ. of Miami.B343 527.4 Mitotic arrest induced by propargylic enolethers derivatives. C.P. Rios Luci, L.G. León, J.C. Montero,D. Tejedor, A. Pandiella, F. García-Tellado and J.M. Padrón.Univ. de La Laguna, Univ. of Salamanca and CSIC, Santa Cruzde Tenerife, Spain.B344 527.5 Identification of the putative drug binding sitefor novel agonists of the integrin CD11b/CD18. D.G. Stoub,V. Gupta, M. Faridi, D. Maiguel, C. Barth and S. Schurer.Rollins Col., FL and Univ. of Miami.B345 527.6 Mechanisms of successful drug action. D.C.Swinney and J. Anthony. Roche Palo Alto.138

sunday528. Mode of Action of Bioactive NaturalProductsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB346 528.1 Effects of specific phytocompounds oninduction of immunogenic tumor cell death and its applicationas adjuvant of dendritic cell-based vaccine. H-m. Chen, S-s.Chen and N-s. Yang. Agr. Biotechnol. Res. Ctr., Acad. Sinica,Natl. Yang Ming Univ., Taiwan and IgE Therapeut. Inc., SanDiego.B347 528.2 Effect and mechanism of action of pine barkextract on glucose uptake by Caco-2 cells. O.M. El-Zein andS.I. Kreydiyyeh. American Univ. of Beirut.B348 528.3 Modulatory effects of Emblica officinalis (amla)on adipocytokines in mice fed high fat diet. G.K. Kipyakwai,L.M. Buesa and P.V. Nerurkar. Univ. of Hawaii.B349 528.4 Using naturally derived compounds to combatHIV: a case for complementary and alternative medicinalmodalities. V. Narayan, C. Chiaro, A.J. Henderson and K.S.Prabhu. Penn State and Boston Univ.B350 528.5 GM-CSF plays a key role in zymosan-stimulatedhuman dendritic cells for activation of Th1 and Th17 cells. W-C.Wei, Y-H. Su, V. Staniforth, J-H. Sheu and N-S. Yang. Agr.Biotechnol. Res. Ctr., Acad. Sinica, Taipei and Natl. Sun Yat-Sen Univ., Taiwan.529. New Targets for Drug Discovery:AntibacterialsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 1:00 p m-2:10 p mB351 529.1 Efflux pump upregulation in DTAC-resistantSalmonella. A. Dvorzhinskiy, M. Kautz and D.S. Herson.Univ. of Delaware.B352 529.2 Mechanistic studies of the enoyl-ACPreductase from Yersinia pestis and its inhibition by diaryl ethercompounds. S. Ng, H. Lu, K. Bostrom, R. Slayden and P.J.Tonge. Stony Brook Univ. and Colorado State Univ.530. Evaluating Pedagogical Approaches toBMB EducationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDEducationPresentation time: 1:00 p m-2:10 p mB353 530.1 Development of a laboratory skills survey andassessment tool for use in the biochemistry teaching laboratory.B.D. Caldwell and M. Daggett. Missouri Western State Univ.B354 530.2 Using assessment data to direct instructionalpractices in the biochemistry classroom. J. Loertscher, V.Minderhout, J. Lewis and S. Villafane. Seattle Univ. and Univ.of South Florida.Biochemistry531. Innovative Approaches to Learning andProfessional DevelopmentPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDCareer DevelopmentPresentation time: 1:00 p m-2:10 p mB355 531.1 Creativity and innovation in teaching andlearning: the significant need for educational reform. S. AbdelKader. Harris-Stowe State Univ., MO.B356 531.2 When reduction leads to expansion: a simplenative PAGE gel enzyme assay experiment as a starting pointfor other structure-function investigations. J.T. Hazzard, D.Pasalic, S. Edwards and K. Friedrich. Univ. of Arizona andPortland Community Col., OR.B357 531.3 DNA analysis using polymerase chainreactions and micro-electrophoresis. R.T. Hunley, J. Harwood,J.O. Boles and M. Mancuso. Tennessee Technol. Univ.B358 531.4 Real time PCR quantification of p21upregulation in UV-irradiated HaCat cells. J.L. Middleton, J.Meads and R. Waikel. Eastern Kentucky Univ.B359 531.5 Team-based learning activities in the academicresearch laboratory. R.V. Stahelin. Indiana Univ. Sch. of Med.,South Bend and Univ. of Notre Dame.B360 531.6 A summer at the bench instead of the beach:integration of high school teachers and students in the researchlaboratory. M.A. Wallert, S. Richter, W. Vicki, D. Hammes andJ.J. Provost. Minnesota State Univ. Moorhead and DetroitLakes H.S.B361 531.7 ABO blood group genotyping by PCR-RFLP.T.W. Wheeler and R.L. Waikel. Eastern Kentucky Univ.B362 531.8 Protein analysis using microelectrophoresisand microspectroscopy. M.M. Whitson, M.C. Mancuso, J.J.Harwood and J.O. Boles. Tennessee Technol. Univ.532. Preparing BMB Students for aMultidisciplinary WorldPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDEducationPresentation time: 1:00 p m-2:10 p mB363 532.1 Post-genomics era topics in multidisciplinarybiology courses. M. Candas. Univ. of Texas at Dallas.B364 532.2 Structuring multidisciplinary biology courses—acase study: cellular microbiology. M. Candas. Univ. of Texas atDallas.B365 532.3 Multidisciplinary biology training—undergraduatestudent perspective. M. Candas, R. Sessoms and K.Lebens. Univ. of Texas at Dallas.B366 532.4 Undergraduate laboratory: increasingawareness of the role of lipids in biochemistry. R.V. Stahelin, D.Cherney and A. Kanovsky. Indiana Univ. Sch. of Med., SouthBend, Univ. of Notre Dame and Indiana Univ., South Bend.sun139

nutritionsundayNutrition533. Vitamin KPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A1 I 533.1 Measurement of vitamin Khomologues in biological fluids and tissues by APCI LC/MS.S.W. Leonard, T. Barker, D.J. Mustacich and M.G. Traber.Oregon State Univ. and Orthoped. Specialty Hosp., Murray,UT.A2 II 533.2 The action of vitamin K in brain duringaging is linked to the pAKT/AKT signaling pathway. F. Guylaine,A. Mabit, C. Fournier and J. Letourneau. Sacred Heart Hosp.of Montreal.A3 I 533.3 Phylloquinone, MK-4 and MK-7contents of some commercially available oral supplements. G.Ferland, W.R. Bartle, C. Fournier and C. Baker. Sacred HeartHosp. of Montreal and Sunnybrook Hlth. Sci. Ctr., Toronto.A4 II 533.4 Stability and clinical determinants oflong-term warfarin therapy: a retrospective study. G. Ferland,K. Desjardins, N. Presse and C. Pharand. Sacred HeartHosp. Res. Ctr., Montreal.A5 I 533.5 Influence of dietary weight-loss onvitamins D and K in obese postmenopausal women. M.K. Shea,B.J. Nicklas, D.K. Houston, E. Saltzman, S.B. Kritchevskyand S.L. Booth. Wake Forest Univ. Sch. of Med. and USDA atTufts Univ.534. Vitamin EPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A6 I 534.1 Zebrafish as a model to determinethe mechanisms of vitamin E function. G.W. Miller, E.M. Labut,K. Lebold, A. Floeter, R.L. Tanguay and M.G. Traber. OregonState Univ.A7 II 534.2 Investigation of w-hydroxylation oftocopherols by CYP4F2 and by rat liver slices. S.M. Farley,S.W. Leonard, D.J. Mustacich, E.M. Labut and M.G. Traber.Oregon State Univ.A8 I 534.3 Chronic alcohol consumption causeshyperlipidemia and depleted vitamin E status in cynomolgusmonkeys. K. Lebold, S.W. Leonard, G. Miller, K. Grant andM.G. Traber. Linus Pauling Inst., Corvallis and Oregon Hlth. &Sci. Univ.535. Antioxidant NutritionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A9 I 535.1 Endothelial protective effects oferythritol. G. den Hartog, A. Berger and A. Bast. MaastrichtUniv., Netherlands and Cargill, Wayzata, MN.A10 II 535.2 DNA damage determined by singlecell gel electrophoresis using cryopreserved lymphocyte, frozenwhole blood in EDTA tube or DNA stabilized tube. C.F. Ronchi,C.B. Berchieri-Ronchi, C.R. Correa, A.L.A. Ferreira, Y. Zhao,S.W. Kim and K-J. Yeum. USDA at Tufts Univ., Botucatu Med.Sch., São Paulo State Univ-UNESP and North Carolina StateUniv.A11 I 535.3 Antioxidant effect of ethanol extract ofpowdered grape skin in C57BL/6J mice fed high-fat diet. H-J.Park, S-J. Choi, Y-B. Park and M-S. Choi. Kyungpook Natl.Univ., Republic of Korea.A12 II 535.4 Effect of phospholipids on the stabilityand absorption of açaí anthocyanins. J.A. Cardona, S.T.Talcott and S.U. Mertens-Talcott. Texas A&M Univ.A13 I 535.5 Angiogenic and inflammatoryactivities are modulated in vivo by polyphenol supplementedbeer. R. Negrão, R. Costa, D. Duarte, T. Taveira-Gomes, M.Mendanha and R. Soares. Fac. of Med., Univ. of Porto andHosp. of São João, Portugal.A14 II 535.6 g-Tocopherol supplementationimproves postprandial vascular endothelial function in leanand obese men by decreasing oxidative and nitrative stress. E.Mah, K.D. Ballard, D.M. Kawiecki, J.S. Volek and R.S. Bruno.Univ. of Connecticut.A15 I 535.7 Antioxidants-induced cytokinealterations indicative of a better prognosis after ACL surgery. T.Barker, T.B. Martins, H.R. Hill, C.R. Kjeldsberg, R.H. Trawick,S.W. Leonard, J.A. Walker and M.G. Traber. Orthoped.Specialty Hosp., Murray, UT, ARUP, Salt Lake City, Univ. ofUtah and Linus Pauling Inst., Corvallis.A16 II 535.8 Oxidative stress status of high prolificsows during pregnancy and lactation. C.B. Berchieri-Ronchi,Y. Zhao, C.R. Correa, A.L.A. Ferreira, K-J. Yeum and S.W.Kim. USDA at Tufts Univ., Botucatu Med. Sch., São PauloState Univ. and North Carolina State Univ.A17 I 535.9 Comparison of ABTS/DPPH assaysfor the detection of antioxidant capacity in foods. A. Floegel,D-O. Kim, S-J. Chung and O.K. Chun. Univ. of Connecticut,German Inst. of Human Nutr. Potsdam-Rehbruecke and KyungHee Univ. and Kookmin Univ., Republic of Korea.A18 II 535.10 Press juices from hamour and kingfishexhibit antioxidant properties. M.I. Waly, J.N. Al-Sabahi, M. Al-Bulishi and B. Soussi. CAMS, Sultan Qaboos Univ., Omanand Gothenburg Univ., Sweden.536. Regulation of Mineral MetabolismPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A19 I 536.1 Genetic determinants for yeast’sresistance to copper, iron and zinc overload. W. Jo, A.Loguinov, M. Chang, P. Wong, H. Wintz, L. Zhang, M. Smithand C. Vulpe. Sch. of Publ. Hlth., Univ. of California, Berkeley.A20 II 536.2 The role of non-synonymous ZnT2gene polymorphisms in cellular Zn homeostasis in mammaryepithelial cells. Y.A. Seo and S.L. Kelleher. Penn State.A21 I 536.3 Zip5: a candidate protein for zinctransport from maternal circulation into the mammary gland.V.R. Velasquez and S.L. Kelleher. Penn State.140

sunday537. Vitamin and MineralsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A22 I 537.1 Methodological issues in assessing25-hydroxy-vitamin D levels in newborns. S. Gallo, S. Agellon,C.A. Vanstone, H.A. Weiler and C. Rodd. McGill Univ., Ste.Anne de Bellevue and Montreal Children’s Hosp., McGill Univ.Hlth. Ctr.A23 II 537.2 Dietary vitamin D intake and foodsources of U.S. and Canadian population. S.S. Jonnalagadda,A.M. Albertson, N. Joshi, K. Moore, B. Sharma and J.M.Culp. General Mills Inc., Golden Valley, MN and General MillsIndia Pvt Ltd., Mumbai.A24 I 537.3 Oral dosing of vitamins K1 and K2in ovariectomized rats: effects on bone loss and serum/bonelevels. J. Moreines, X. Fu and S. Booth. Wyeth ConsumerHealthcare, Madison, NJ and USDA at Tufts Univ.A25 II 537.4 Riboflavin protects againstlipopolysaccharide-induced shock via HSP25 in mice. C-Y.O.Chen, C-M. Chen, C-K. Shih, H-T. Chou, J-F. Liu and S-C.Li. USDA at Tufts Univ. and Shih Chien Univ., Taiwan, Sch. ofNutr. and Hlth. Sci., Taipei Med. Univ. and Taipei Med. Univ.-Wan Fang Hosp.A26 I 537.5 Sequence of the peptide componentof low-molecular-weight chromium-binding substance. J.B.Vincent, Y. Chen, H. Watson and C.J. Cassady. Univ. ofAlabama.A27 II 537.6 Urinary chromium loss associatedwith diabetes is offset by increases in absorption. J.B. Vincent,N.R. Rhodes, D. McAdory, S. Love, K.R. Di Bona and J.F.Rasco. Univ. of Alabama.A28 I 537.7 Effect of long-term Western style dietand folate supplementation on aortic response and hepaticC-reactive protein level in C57BL/6 mice. E.H. Kong, S.T.Hasan, H. Jang, E.M. Zimmerly, S.W. Choi and M. Meydani.Kosin Univ., Republic of Korea and USDA at Tufts Univ.A29 II 537.8 Analysis of mineral contents in bottlednatural water and estimation of their intake in Korean adults.M-K. Choi, M-K. Kim, J-A. Sim, H-J. Eom, M-H. Kim and M-H.Kang. Kongju Natl. Univ. and Hoseo Univ., Republic of Korea.A30 I 537.9 Dietary intakes of vitamin A and Eof Korean adults living in Seoul, Korea. Y-N. Kim, J.Y. Jang,H. Roh and Y-O. Cho. Duksung Women’s Univ., Republic ofKorea.A31 II 537.10 Maternal serum retinol and theoutcome of pregnancy (Camden Study). T.O. Scholl, X. Chen,M. Schluter, M. Leskiw and T.P. Stein. UMDNJ-Sch. of Osteo.Med.A32 I 537.11 Vitamin D dose response study inCanadian infants: 25-hydroxy-vitamin D status during a 20-week intervention. S. Gallo, C.A. Vanstone, K. Comeau, S.Agellon, C. Rodd, A. Sharma and H.A. Weiler. McGill Univ.,Ste. Anne de Bellevue and Montreal Children’s Hosp.A33 II 537.12 Vitamin D status in overweightand obese individuals during a controlled calorie restrictedintervention. B. Piccolo, E.R. Gertz, L. Hall, M. Cheema,L. Woodhouse, E. Souza, N.L. Keim, S.H. Adams, C.B.Stephensen and M.D. Van Loan. Univ. of California, Davis,USDA, Davis and California Polytech State Univ., San LuisObispo.nutritionA34 I 537.13 Investigating the complex formationbetween boron and riboflavin using electrospray ionizationmass spectrometry and fluorescence spectroscopy. D.H. Kim,K.F. Faull and C.D. Eckhert. California State Univ., Fullertonand UCLA.A35 II 537.14 Improved HPLC method for vitamin Canalysis in serum. N.E. Craft and H. Park. Craft Technol. Inc.,Wilson, NC.A36 I 537.15 Vitamin D status of Florida collegestudents. W.J. Dahl, B. Langkamp-Henken, L. Foster, J.Stolarz and S.J. Whiting. Univ. of Florida and Col. of Pharm.and Nutr., Univ. of Saskatchewan.A37 II 537.16 Cancer chemotherapeutic effects ofmodified sodium silicate (alkahydroxy/Alka V6). D. Townsend,L. White, T. Chesnut, S. Duesler, I. Cisneros, C.R. Richardsonand D. Vattem. Texas State Univ. and Orizon Res. Inst. andCisne Enterprises Inc., Odessa, TX.A38 I 537.17 Long-term, physiological dose ofprednisolone treatment alters vitamin B6 metabolism invivo. H-Y. Chang and E-P.I. Chiang. Dept. of Food Sci. andBiotechnol., Taichung, Taiwan.A39 II 537.18 Association of dietary and serumfolate in a cohort of asymptomatic HIV + patients in Botswana. R.Marlink, H. Bussmann, H. Masmouie, P.J. Burns, L. Tsalaile,M. Raesi, J. Makhema, A. Campa and M.K. Baum. HarvardSch. of Publ. Hlth., Botswana Harvard Partnership, Gaborone,Botswana and Col. of Publ. Hlth., Florida Intl. Univ.A40 I 537.19 Anti-retroviral effects of modifiedsodium silicate (Alkahydroxy/Alka V6). D. Townsend, L. White,T. Chesnut, S. Duesler, I. Cisneros, C.R. Richardson andD. Vattem. Texas State Univ. and Orizon Res. Inst. and CisneEnterprises Inc., Odessa, TX.A41 II 537.20 Differential modulation of biomarkersof metabolic syndrome in C57BL/6J mice by isomers oftocopherol. S. Sundaresan, N. Mills, C. Prasad, S. Juma, P.Vijayagopal and V. Imrhan. Texas Woman’s Univ.A42 I 537.21 Altered nutrient status in alcoholexposedpregnant women. J.Y. Uriu-Adams, H.B. Gross, C.D.Chambers, K. Green, J.L. Ensunsa, A. Le, L. Yevtushok, W.Wertelecki and C.L. Keen. Univ. of California, Davis, UCSD,OMNI-Net, Rivne, Ukraine and Univ. of South Alabama.A43 II 537.22 Blood mineral levels of Mexicanadults, results of a national probabilistic survey. T. ShamahLevy, S. Villalpando and F. Mejía-Rodríguez. Natl. Publ. Hlth.Inst., Cuernavaca.A44 I 537.23 Evidence of in vivo immunemodulation with vitamin D3 and calcium supplementation inmultiple sclerosis. S.M. Kimball, R. Vieth, A. Bar-Or, D. Gagne,H.M. Dosch, R. Cheung, P.G. O’Connor and J. Burton. Univ.of Toronto, Mount Sinai Hosp., Toronto, Montreal Neurol. Inst.,Hosp. for Sick Children and St. Michael’s Hosp., Toronto andUniv. of Calgary.A45 II 537.24 Provitamin A from Golden Rice is aseffective as provitamin A in oil to children. G. Tang, S-a. Yin, Y.Wang, M. Grusak and R. Russell. USDA at Tufts Univ., Natl.Inst. for Nutr. and Food Safety, Beijing, Zhejiang Acad. of Med.Sci., People’s Republic of China and USDA, Houston.A46 I 537.25 The effect of sulfasalazine onhomocysteine metabolism in vivo. Y-T. Wu and E-P.I. Chiang.Natl. Chung Hsing Univ., Taiwan.sun141

nutrition538. International Nutrition: MicronutrientDeficienciesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A47 I 538.1 Hemoglobin and blood leadassociated with mothers’ perceptions of the relationship withtheir children. K. Kordas, E.I. Queirolo, G. Ardoino and N.Manay. Penn State, Catholic Univ. of Uruguay and Univ. ofRepublic, Uruguay.A48 II 538.2 A randomized trial of multivitaminsupplementation in children with tuberculosis in Tanzania. S.Mehta, F.M. Mugusi, R.J. Bosch, S. Aboud, A. Chatterjee,J.L. Finkelstein, M. Fataki, R. Kisenge and W.W. Fawzi.Harvard Sch. of Publ. Hlth., Muhimbili Univ. of Hlth. and AlliedSci., Tanzania and UNICEF, NY.A49 I 538.3 Can dietary treatment without ironsupplementation correct mild iron deficiency anemia in youngBeninese adolescent girls? H. Alaofè, J. Zee, R. Dossa andH. Turgeon O’Brien. Univ. Laval, Canada and Univ. d’AbomeyCalavi, Benin.A50 II 538.4 Iron deficiency in adolescent schoolgirls from Tigray, Northern Ethiopia. A. Mulugeta, M. Gebre,M. Abdelkadir, A. G.tsadik, A. G.yesus and B.J. Stoecker.Mekelle Univ., Ethiopia, Oklahoma State Univ. and Tigray Hlth.Bureau, Ethiopia.A51 I 538.5 Assessment of iron and zinc statusof women and their children in Jordan and evaluation ofsensitivity and specificity of transferrin receptors in identifyingiron deficiency. M. Gharaibeh and B.J. Stoecker. OklahomaState Univ.A52 II 538.6 Zinc absorption from traditional mealsby vitamin A-depleted Bangladeshi women is greater in thosewith altered intestinal permeability, while iron absorption is notaffected. A.B. Perez-Exposito, L. Woodhouse, M.J. Haskell,K.M. Jamil, G. Barfod, M.A. Wahed and K.H. Brown. Univ.of California, Davis, USDA, Davis and ICDDR,B, Dhaka,Bangladesh.A53 I 538.7 Capillary versus venous blood:delayed measurement of hemoglobin concentrations andhematocrit. B.S. Drammeh, U. Mandava, M. Zhang, R.L.Schleicher and C.M. Pfeiffer. Ctrs. for Dis. Control andPrevent. and Battelle Mem. Inst.A54 II 538.8 Three models of HemoCuephotometers: comparison of venous blood hemoglobinconcentrations and influence of heat on cuvettes. U. Mandava,B.S. Drammeh, M. Zhang, R.L. Schleicher and C.M. Pfeiffer.Ctrs. for Dis. Control and Prevent. and Battelle Mem. Inst.A55 I 538.9 Mapping of anemia prevalence amongHonduran children ages 6-60 months using global positioningsystem data. A.A. Stoltenburg, T.M. Kemmer, V. Gidvani-Diaz, D. Lougee, M. Coello, W.E. Amador, J. Lynch and P.Thanapura. South Dakota State Univ., San Antonio MilitaryPediat. Ctr., Joint Task Force Bravo, Honduras and Walter ReedArmy Inst. of Res.A56 II 538.10 Low dietary intake of vitamina B12predicts hyperhomocysteinemia in Mexican women. M.A.Anaya-Loyola, C. Sosa Alvarez, J.L. Rosado Loria and L.H.Allen. Autonomous Univ. of Querétaro, Mexico and USDA,Davis.sundayA57 I 538.11 Iodine status of women from selectedrural areas of Sidama Zone, southern Ethiopia. T. G/Egziabher,B.J. Stoecker, A. Mulugeta, A. Bogale, M. Girma, Y. Abebeand K.M. Hambidge. Oklahoma State Univ., Hawassa Univ.and Mekelle Univ., Ethiopia and Univ. of Colorado Denver.A58 II 538.12 Effect of zinc supplementation ondiarrhea and malaria morbidity in adults in rural Kenya. A.G.Scrimgeour, H.C. Lukaski, M.E. Polhemus, L. Otieno, S.M.McGraw, A.J. Young and M.E. Bovill. U.S. Army Res. Inst.of Envrn. Med., Natick, MA, USDA, Grand Forks, USAMRU-Kenya and KEMRI/Walter Reed Project, Kisumu, Kenya.539. Carotenoids and Health IIPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A59 I 539.1 Bioconversion of b-cryptoxanthininto polar metabolites other than vitamin A. J.R. Mein, G.Dolnikowski, R. Russell and X-D. Wang.A60 II 539.2 Tomato extract supplementationresults in a preferential accumulation of hepatic phytoene andphytofluene and decreased plasma total cholesterol levels inhigh fat diet fed rats. A.J. Melendez-Martinez, Y. Wang, J.R.Mein and X-D. Wang. USDA at Tufts Univ. and Univ. of Seville.A61 I 539.3 Dietary fats with increasedratio of unsaturated to saturated fatty acids enhanceabsorption of carotenoid and vitamin E by increasing bothefficiency of micellarization and lipoprotein secretion. C.Chitchumroonchokchai, M.L. Failla, M.G. Ferruzzi and W.W.Campbell. Ohio State Univ. and Purdue Univ.A62 II 539.4 Efficiency of intestinal absorption ofbeta-carotene is not correlated with cholesterol absorption inhumans. M.K. Fleshman, K.A. Cope, J.A. Novotny, K. Riedl,S.J. Schwartz, P.J. Jones, D.J. Baer and E.H. Harrison. OhioState Univ., NHLBI, NIH, USDA, Beltsville, MD and Univ. ofManitoba.A63 I 539.5 Carotenoid levels in aging humanbrain with reduced cognitive function. M.G. Ferruzzi, L. Ho andG.M. Pasinetti. Purdue Univ., Mount Sinai Sch. of Med. andJames J. Peters VA Med. Ctr., Bronx.A64 II 539.6 Production of [ 13 C]-lycopene from highlycopene tomato cell suspension cultures. N.J. Engelmann,R.B. Rogers, S.I. Rupassara, P.J. Garlick, M.A. Lila and J.W.Erdman, Jr. Univ. of Illinois, Urbana.A65 I 539.7 Genotype and diet alter carotenoidbioaccumulation and the expression of carotenoid cleavageenzymes in CMO-I KO, CMO-II KO, and wild-type mice. N.A.Ford, S.K. Clinton, J. von Lintig and J.W. Erdman, Jr. Univ.of Illinois at Urbana Champaign, Ohio State Univ. Col. of Med.and Case Western Reserve Univ.A66 II 539.8 Does lycopene or tomato powderimpact lipid metabolism in CMO-I KO and CMO-II KO mice?A.C. Elsen, N.A. Ford, J. von Lintig and J.W. Erdman, Jr.Univ. of Illinois at Urbana-Champaign and Case WesternReserve Univ.A67 I 539.9 Effects of lutein and b-cryptoxanthinon MMP-13, PGE2 and cytokine production in humanchondrosarcoma cells stimulated with IL-1a in vitro. B.P.Chew, M.M. Di Filippo and B. Mathison. Sch. of Food Sci.,Washington State Univ.142

sundayA68 II 539.10 Tomato carotenoid bioaccumulationand gene expression of carotenoid cleavage enzymes arealtered by soy germ in male Copenhagen rat tissues. K.E.Zuniga and J.W. Erdman, Jr. Univ. of Illinois at Urbana-Champaign.A69 I 539.11 A lutein enriched diet modifiedlipoprotein subfractions and prevented cholesterol accumulationin aortas in guinea pigs. J.E. Kim, J.O. Leite, R. DeOgburn,R.M. Clark and M.L. Fernandez. Univ. of Connecticut.A70 II 539.12 Reductions of atherogenic lipoproteinsare related to concentrations of plasma carotenoids inwomen following a Mediterranean-style low glycemic diet. J.Barona, R. Kopec, J. Jones, R. Lerman, S. Schwartz andM.L. Fernandez. Univ. of Connecticut, Ohio State Univ. andMetaProteomics LLC, Gig Harbor, WA.A71 I 539.13 Developmental aspects of lycopeneaction to disaccharidases kinetic parameters of chickenjejunal brush border. A.A. Bugay and M.I. Tsvilikhovskii.Dnipropetrovs’k State Agr. Univ. and Natl. Univ. of Envrn. andLife Sci., Ukraine.A72 II 539.14 Aggregation behavior of xanthophylls.J.T. Landrum and D. Babino. Florida Intl. Univ.A73 I 539.15 The dose-response effects ofthe amount of oil in salad dressing on the bioavailability ofcarotenoids and fat-soluble vitamins in salad vegetables. A.Agustiana, Y. Zhou, L. Flendrig and W.S. White. Iowa StateUniv. and Unilever R&D, Vlaardingen, Netherlands.A74 II 539.16 Intracellular accumulation andmetabolism of beta-carotene and lycopene in normal andnon-small cell lung cancer cells. R. Marisiddaiah, X. Gong, D.Wiener and L.P. Rubin. Univ. of South Florida.540. Dietary Bioactive Compounds IncludingBotanicals IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A75 I 540.1 The effect of soy diets on obesityrelatedpathologies in lean and obese Zucker rats. J. Cain, J.E.Davis, A. Strader and D. Butteiger. Southern Illinois Univ. andSolae LLC , St. Louis.A76 II 540.2 Endocrine and safety assessmentpre- and post-ingestion of natural S-equol for 12 weeks inhealthy Japanese adult males. B.H. Jenks, S. Iwashita andS. Uchiyama. Pharmavite LLC, Northridge, CA and OtsukaPharmaceut. Co., Saga, Japan.A77 I 540.3 Preventing bone loss and weight gainwith combinations of vitamin D and phytochemicals. C-Y. Lai,S. Ambati, M.A. Della-Fera, M.W. Hamrick, S. Rayalam, M.Wolfe, J-Y. Yang, D.L. Hartzell, R. Lewis and C.A. Baile. Univ.of Georgia and Med. Col. of Georgia.A78 II 540.4 Pharmacokinetics of dietary equol inovariectomized rats. L.L. Legette, J.K. Prasain, A. Arabshahi,S. Barnes and C.M. Weaver. Purdue Univ. and Univ. of Alabamaat Birmingham.A79 I 540.5 Effect of soy diets and equol onfemale depressive behaviors and body weight in Long-Evansrats. C. Blake, K.D.R. Setchell, T.D. Lund and E.D. Lephart.Brigham Young Univ., Cincinnati Children’s Hosp. Med. Ctr. andStoelting Co., Wood Dale, IL.nutritionA80 II 540.6 Lifetime dietary exposure to soyisoflavones is beneficial to prostate and testicular health in 100day-old male Long-Evans rats. C. Blake, T. Hansen, B. Hogen,I. Bourgeois and E.D. Lephart. Brigham Young Univ.A81 I 540.7 Arterial tissue culture mediumaccelerates anthocyanin degradation and polymeric formationin extracts from chokeberry, bilberry and elderberry. D.R. Bell,R.E. Nalliah, S.J. Cressman, A.J. Swartz and H. Moon.Indiana Univ. Sch. of Med. and Huntington Univ., IN.A82 II 540.8 Chocolate matrix factors modulatepharmacokinetic behavior of cocoa flavan-3-ols followingoral consumption by Sprague-Dawley rats. A.P. Neilson, T.N.Sapper, E.M. Janle, R.D. Mattes, R. Rudolph, N.V. Matusheskiand M.G. Ferruzzi. Purdue Univ. and Kraft Foods Inc., Munichand Glenview, IL.A83 I 540.9 Comparison for bioavailability of1-deoxynojirimycin with mulberry water extract in rat. J.Y. Kim,H.J. Kwon, J.Y. Jung, D.R. Kim, Y.S. Kim and O. Kwon. EwhaWomans Univ., Republic of Korea.A84 II 540.10 Adjunctive effects of a dietarysupplement comprising dried whole fruit, vegetable andberry juice concentrates on clinical outcomes of treatmentof periodontitis. I.L.C. Chapple, M.M. Milward, N. Ling-Mountford, P. Weston, G.E. Dallal and J.B. Matthews. Univ.of Birmingham and USDA at Tufts Univ.A85 I 540.11 Poly-g-glutamate intake increasesglutamate and GABA concentrations of serum and brain.S-H. Kim, H-S. Lee, B. Kim and M-J. Chang. Kookmin Univ.,Republic of Korea.A86 II 540.12 Impact of orally consumed Lyciumbarbarum on various urinary neurotransmitter levels in healthyhuman male adults. H. Amagase. FreeLife Intl., Phoenix.A87 I 540.13 Comparison of Lycium barbarumcontainingliquid dietary supplements to caffeinated beverageson energy/caloric metabolism activity and salivary adrenocorticalhormone levels in healthy human adults. H. Amagase. FreeLifeIntl., Phoenix.A88 II 540.14 Cassia cinnamon supplementationbefore an oral glucose tolerance test in overweight or obeseyoung women. J.L. Gutierrez, M. Cooke, R. Lutz, B. Rodney,R. Kane and D. Willoughby. George Washington Univ. andBaylor Univ.A89 I 540.15 Quercetin causes dose-relatedincreases in energy expenditure and PGC1a in muscle ofC57BL/6J mice. T.M. Henagan, N.R. Lenard, H. Rietschier, S.Anaya, T.W. Gettys, W.T. Cefalu and L.K. Stewart. LSU, OurLady of Lake Col. and Pennington Biomed. Res. Ctr., BatonRouge.A90 II 540.16 Compound K produces cardiacprotection by activating Akt phosphorylation. R. Tsutsumi, K.Mawatari, E. Katayama, Y. Nakaya and Y.M. Tsutsumi. Univ.of Tokushima, Japan.A91 I 540.17 Saponins from yerba mate (Ilexparaguariensis St. Hilaire) leaves inhibit markers of inflammationin vitro through NFkB pathways. S. Puangpraphant, M. Berhowand E. Gonzalez de Mejia. Univ. of Illinois, Urbana and USDA,Peoria.A92 II 540.18 Improved prep-scale isolation ofglucosinolates from cruciferous vegetables using a novelstationary phase. C. Scholl, D. Barnes and P. Hanlon.Standard Process Inc., Palmyra, WI.sun143

nutritionA93 I 540.19 Dietary cotton-seed oil attenuatessecretion of adhesion molecules by human umbilical veinendothelial cells. S. Sundaresan, S. Sodhani, P. Vijayagopal,N. Mills, V. Imrhan and C. Prasad. Texas Woman’s Univ.A94 II 540.20 Effects of a single high-fat meal rich incottonseed oil on lipid profile, insulin sensitivity, and multimericforms of adiponectin of healthy females. S. Sodhani, S.Sundaresan, K. Makkieh, V. Imrhan, N. Mills, P. Vijayagopaland C. Prasad. Texas Woman’s Univ.A95 I 540.21 Pyrroloquinoline quinone nutritionalstatus in humans after oral supplementation. C. Harris, W.Chowanadisai, M. Satre, K. Bauerly, K. Bauerly and E.Tchaparian. Univ. of California, Davis and Amgen Inc.541. Dietary Bioactive Compounds I:Mechanisms of Action and MolecularTargets IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A96 I 541.1 Hepatoprotective effects of soybeanvarieties containing different levels of isoflavones andanthocyanins against carbon tetrachloride-induced liver injuryin mice. J-S. Kim, J. Park, J. Lim, D.H. Nam, Y.S. Hong, M.Y.Han, H.J. Kim and J.Y. Seo. Sch. of Applied Biosci., KyungpookNatl. Univ, Republic of Korea.A97 II 541.2 Antioxidative activities of isoflavonesmetabolites generated by fermentation with Bacillus speciesisolated from cheonggukjang, a traditional Korean fermentedsoyfood. J-S. Kim, D.H. Nam, J.S. Lim, J. Park, Y.S. Hong,J.Y. Seo, M.Y. Han and H.J. Kim. Sch. of Applied Biosci.,Kyungpook Natl. Univ., Republic of Korea.A98 I 541.3 Indole-3-carbinol suppressedinflammation-associated factors in mice fed with high-fat dietand in cocultured cells. H-P. Chang and Y-H. Chen. Sch. ofPharm. and Sch. of Nutr. and Hlth. Sci., Taipei Med. Univ.A99 II 541.4 Hepatoprotective effect ofdehydroglyasperin C against carbon tetrachloride-inducedtissue damage in mice model. J-S. Kim, J-Y. Seo, H-J. Kim,J.S. Lim, J-A. Park, D.H. Nam, Y-S. Hong, M.Y. Han, S.S. Limand J.H. Yoon Park. Sch. of Applied Biosci., Kyungpook Natl.Univ. and Hallym Univ, Republic of Korea.A100 I 541.5 Effects of green tea and EGCG onIL-8 inflammatory responses in LPS and TNF-a-induced,differentiated HT-29 human colon cancer cells. E. Story and G.Harris. North Carolina State Univ.A101 II 541.6 Cranberry phytochemicals act asnonmicrobial antigens for different types of human peripheralblood mononuclear cells. C.A. Rowe, C. Montero, M.P. Nantz,C. Khoo and S.S. Percival. Univ. of Florida and Ocean SprayCranberries Inc., Lakeville, MA.A102 I 541.7 Genistein stimulates nitric oxidesynthesis in human vascular endothelial cells via activationof cAMP-response element binding protein. D. Liu and H. Si.Virginia Tech.A103 II 541.8 Modulation of redox/nitric oxidesignaling by Lamiaceae herbs in seminal vesicles of Lumbricusterrestris. R.C. DeLeon, C. Lester, V. Maitin and D. Vattem.Texas State Univ., San Marcos.sundayA104 I 541.9 Curcumin modulates hemeoxygenase-1, eNOS, and endothelial cell cycle progression. S.J.T.Jackson, R.C. Venema, L.L. Murphy, K.W. Singletary andA.J. Young. U.S. Army Res. Inst. of Envrn. Med., Natick, MA,Med. Col. of Georgia, Southern Illinois Univ. and Univ. of Illinois,Urbana.A105 II 541.10 The roles of caveolin-1 and hemeoxygenase-1 in EGCG-mediated protection against TNFa-inducedendothelial inflammation. Y. Zheng, J. Layne, M.Toborek and B. Hennig. Col. of Agr., Univ. of Kentucky.A106 I 541.11 Effects of epigallocatechin gallate onregulatory T cell number and function in obese versus leanvolunteers. J-M. Yun and I. Jialal. Univ. of California DavisMed. Ctr.A107 II 541.12 Dietary sitosterol, stigmasterol,and stigmastanol stearate esters elicit similar responses onhepatic and plasma lipids and cholesterol absorption in Syrianhamsters. M.M. Ash, J. Hang, P.H. Dussault and T.P. Carr.Univ. of Nebraska-Lincoln.A108 I 541.13 Strawberry extract attenuatesoxidative stress-induced impaired insulin signaling in vitro inhuman skeletal muscle cells. K. Sandhya, R. Tadapaneni, K.Banaszewski, J. Cappozzo, I. Edirisinghe and B.M. Burton-Freeman. Illinois Inst. of Technol.A109 II 541.14 Dark chocolate upregulated LDLreceptor gene expression and downregulated fatty acidsynthase expression. N. Shadwell and M.Y. Hong. San DiegoState Univ.A110 I 541.15 Regulation of sterol transporterexpression by plant sterols in HepG2 cells. Y-K. Park and T.P.Carr. Univ. of Nebraska-Lincoln.A111 II 541.16 Molecular structures of citruspolymethoxylated flavonoids determine their inhibitory effecton apoB secretion in HepG2 cells. M.A. Vermeer, Y. Lin, W.Bos, L. van Buren, E. Schuurbiers, S. Miret-Catalan andE.A. Trautwein. Unilever R&D, Netherlands.A112 I 541.17 Effect of pre-adipocyte anddifferentiated adipocyte-conditioned media on galectin-3expression in mouse intestinal epithelial cell. J-S. Kim, A.Garcia, J-Y. Seo, J.S. Lim, J. Park, D.H. Nam and M-K. Sung.Sch. of Applied Biosci., Kyungpook Natl. Univ. and SookmyungWomen’s Univ., Republic of Korea.A113 II 541.18 Epigallocatechin-3-gallate increasesthe expression and secretion of adiponectin protein in 3T3-L1adipocytes. C. Montero, S.C. Frost and S.S. Percival. Univ. ofFlorida.A114 I 541.19 Phytosterols and fatty acids, but notphytosterol esters, affect cholesterol micellarization in vitro.A.W. Brown, J. Hang, P.H. Dussault and T.P. Carr. Univ. ofNebraska-Lincoln.A115 II 541.20 Adiponectin mediates leucine-inducedadipocyte-muscle cross-talk. X. Sun and M.B. Zemel. Univ. ofTennessee, Knoxville.A116 I 541.21 Cinnamon increases liver glycogen,improves insulin sensitivity, and regulates glycogen synthesisrelated gene expression in an animal model of the metabolicsyndrome. B. Qin, K. Couturier, C. Batandier, M. Awada, I.Hininger-Favier, F. Canini, A-M. Roussel and R.A. Anderson.USDA, Beltsville, MD and Joseph Fourier Univ., France.A117 II 541.22 Time-dependent comparison ofconjugated linoleic acid and conjugated nonadecadienoic acidon lipid metabolism in mice. Y. Park, J. Wong, B.H. Kim and Y.Park. Univ. of Massachusetts Amherst and Chung-Ang Univ.,Republic of Korea.144

sundayA118 I 541.23 Tea and policosanol act throughdifferent mechanisms to activate AMP-kinase and suppressHMG-CoA reductase to inhibit cholesterol synthesis. S.Banerjee and T.D. Porter. Univ. of Kentucky.A119 II 541.24 The major green tea polyphenol,epigallocatechin gallate, inhibits 11b-hydroxysteroiddehydrogenase type 1 activity in rodent adipocytes. Y.Kobayashi, M. Wakabayashi, Y. Yamaguchi, D. Kiyonagaand N. Tagawa. Kobe Pharmaceut. Univ.542. Metabolic Phenotyping, Metabolomicsand BiomarkersPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A120 I 542.1 Type 2 diabetes-associated changesin the plasma lipidome in obese women. D. Grapov, S.H.Adams, W.T. Garvey, K.H. Lok and J.W. Newman. Univ. ofCalifornia, Davis and USDA, Davis and Univ. of Alabama atBirmingham.A121 II 542.2 A validated sandwich ELISA for thedetection of von Willebrand factor in rabbit plasma. B.W. Smith,J. Strakova, J.L. King, M.J. Tu, J.W. Erdman, Jr. and W.D.O’Brien, Jr. Univ. of Illinois at Urbana-Champaign.A122 I 542.3 Validated biomarkers of caloricrestriction in rats: markers of disease risk in humans? B. Kristal,W. Matson, W. Willett, S. Hankinson, Y. Shurubor, D. Sheldon,B. Krasnikov, N. Russell, M. Sniatynski and V. Marur. HarvardMed. Sch., Brigham and Women’s Hosp., Bedford VA Hosp.,Harvard Sch. of Publ. Hlth. and BMRI, NY.A123 II 542.4 Changes in small molecular weightbiomarkers identified by NMR spectroscopy in response todietary treatment with two conjugated linoleic acid isomers(c9,t11; t10,c12) in a murine collagen-induced arthritis model.S. Huebner, D.E. Butz, J.P. Campbell, M.E. Cook and F.Assadi-Porter. Univ. of Wisconsin-Madison.A124 I 542.5 Metabolic phenotyping to assesspersonalized nutrition: use of the response-to-challenge model.J.T. Smilowitz, N. Argov, R.A. Eigenheer, D.G. Lemay andJ.B. German. Univ. of California, Davis and Hebrew Univ. ofJerusalem.543. Integrative Biology, Adipocyte Biology,Nutrient Amino Acid and Fatty AcidMetabolismPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A125 I 543.1 Oleic acid enhances GPRr43 andAMPKka in a muscle cell transdifferentiation model. K.Y.Chung and B.J. Johnson. Texas Tech Univ.A126 II 543.2 PFKFB3/iPFK2 links nutrientmetabolism and overnutrition-associated adipocyteinflammatory response through controlling oxidative stress. X.Guo, H. Li and C. Wu. Texas A&M Univ.nutritionA127 I 543.3 Lipin 1 represses NFATc4 transcriptionalactivity in adipocytes to inhibit secretion of inflammatoryfactors. T.E. Harris, H.B. Kim, A. Kumar, L. Wang, S.R. Keller,B.N. Finck and J.C. Lawrence, Jr. Univ. of Virginia andWashington Univ.544. Maternal-Fetal Programming of GeneExpression IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A128 I 544.1 Influence of maternal hypothyroidismin fetal cardiac renin-angiotensin system. C.A. Lino, C.E.R.Shibata and M.L. Barreto-Chaves. Univ. of São Paulo.A129 II 544.2 Nutrient restriction and hypoxiaindependently decrease placental cell proliferation anddifferentially regulate Igf2, Mtd and Phlda 2 gene expression invitro. P.M. Brannon and S. Jones. Cornell Univ.A130 I 544.3 Fructose consumption duringgestation alters glucose metabolism and placental expression ofTNF-a and SNAT2. C. Lineker, N. Patel, A. Dunichand-Hoedland R.C. Bell. Univ. of Alberta and Univ. of Nottingham.A131 II 544.4 Maternal consumption of soy proteinaffects lipid metabolism in the offspring of rats. Y.H. Kwon, S.B.Won and A. Han. Seoul Natl. Univ.A132 I 544.5 Effects of maternal bitter melon(Momordica charantia) supplementation on hepatic lipidmetabolism of fructose-fed dams and their progeny. H.H. Chingand E.T.S. Li. Sch. of Biol. Sci., Univ. of Hong Kong.545. Nutrient Effects of Stem CellDifferentiation and PluripotencyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A133 I 545.1 Dietary calcium affects thedifferentiation potential of mesenchymal stem cells. A. Mahajan,L.S. Alexander, B.S. Seabolt, J. Odle, E.G. Loboa and C.H.Stahl. North Carolina State Univ.A134 II 545.2 Identification of bioactive dietary andnatural components for targeting cancer stem cells. J-R. Zhou,Y. Li, Y. Gong and G. Blackburn. Beth Israel Deaconess Med.Ctr., Harvard Med. Sch.546. Genetics and ObesityPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A135 I 546.1 Association of leptin receptorgene polymorphisms with body fat distribution in multiethnicadolescent girls of Hawaii. V. Vijayadeva, J. Grove, R. Novotny,L. Le Marchand and Y. Daida. Univ. of Hawaii.sun145

nutritionA136 II 546.2 LIPC and LEPR gene polymorphisms:associations with biochemical parameters and obesityphenotypes in Mexican northwest children from the urbanregion. J. Magaña-Gomez, M. Arias-Gastélum, M. Castro-Acosta, J. Hernandez-Morga and M. Vergara-Jimenez.Autonomous Univ. of Sinaloa, Mexico.A137 I 546.3 Association between obesity andmolecular and biochemical parameters related with diabetes inchildren from Sinaloa, Mexico. M. Vergara-Jimenez, M. Arias-Gastélum, M. Castro-Acosta, J. Hernandez-Morga and J.Magaña-Gomez. Autonomous Univ. of Sinaloa, Mexico.547. Metabolic Consequences of Obesity:Molecular Mechanisms IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A138 I 547.1 Total and high molecular weightadiponectin levels in mice with altered GH signaling. E. Lubbers,D.B. Miles, E.O. List, J.J. Kopchick and D.E. Berryman. OhioUniv.A139 II 547.2 Alterations of adipose tissuephenotype and gene expression in olanzapine-treated rats. M.Victoriano, R. de Beaurepaire, N. Naour, M. Guerre-Millo,A. Quignard-Boulange, J-F. Huneau, V. Mathé, D. Toméand D. Hermier. AgroParisTech, Paul Guiraud Hosp., Villejuif,INSERM, Paris and INRA, Paris.A140 I 547.3 Regulation of adipose triglyceridelipase in vivo. D.A. Elkins and D.M. Spurlock. Iowa StateUniv.A141 II 547.4 Transcription factor HBP1 functions asa regulator of adipocyte differentiation. C-Y. Chan, F-T. Chang,H-C. Hung and C-Y. Huang. China Med. Univ., Taiwan.A142 I 547.5 Detection of gamma synuclein proteinin adipocytes. V. Narayanan. Florida Intl. Univ.A143 II 547.6 Regulation of cathepsins in adiposetissue and macrophages in obesity. J.E. Hannaford and X.Chen. Univ. of Minnesota, St. Paul.A144 I 547.7 The pro-adipogenic effect ofadvanced glycation end-products in adipogenesis. C.Y. Chen,A. Martorano and K-H. Kim. Purdue Univ.A145 II 547.8 Sodium selenate inhibits adipogenesisin vitro. J.L. Wiacek and K-H. Kim. Purdue Univ.A146 I 547.9 Obesity induces tissue-specificchanges in lipid peroxidation defense enzymes. M.J. Picklo,Sr. and J. Idso. USDA, Grand Forks.A147 II 547.10 High fat diet-induced obesity inmyostatin null mice. A.C. Dilger, S.R. Gabriel, L.W. Kutzler,D.D. Boler and J. Killefer. Univ. of Illinois, Urbana.A148 I 547.11 The role ofTNFa in circadian rhythmicresponses and regulation of metabolic regulator SIRT1 in liver.J. Menio, I.N. Hines and M.D. Wheeler. East Carolina Univ.and Univ. of North Carolina at Chapel Hill.A149 II 547.12 Disturbances in cardiac glutathioneaugments cardiac lipotoxicity in mice with diet-induced obesity.S. Ghosh, D.C. Sulistyoningrum, M.B. Glier and A.M. Devlin.Univ. of British Columbia.548. Assessment of Obesity: MedicalEvaluation and RiskPostersundaySu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A150 I 548.1 Family dysfunction and obesityin children aged 6 to 9 years old in Guadalajara, Mexico.E. Romero-Velarde, I. Sandoval-Montes, E.M. Vásquez-Garibay, J.L. González-Rico, H. Martínez-Ramírez, E.Sánchez-Talamantes and R. Troyo-Sanromán. Univ. ofGuadalajara, Mexico.A151 II 548.2 Evaluation of abdominal obesity bya portable stereo vision body imaging system. J. Freeland-Graves, M.R. Pepper, J. Lee, Y. Zhu, D. Bean, M. Yao and B.Xu. Univ. of Texas at Austin.549. Comprehensive Weight ManagementPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A152 I 549.1 Comprehensive weight managementprogram for Army ROTC cadets. A. Cardenas, J. Rogers, J.Von Bank, B.J. Friedman and S. Crixell. Texas State Univ.A153 II 549.2 Assessing the role of potatoes andglycemic index in body weight management and glucosetolerance. J.M. Randolph, S. Cheema, C.T. Kappagoda, I.Edirisinghe and B. Burton-Freeman. Univ. of California,Davis, Univ. of California Davis Med. Ctr. and Natl. Ctr. for FoodSafety & Technol., Summit-Argo, IL.A154 I 549.3 A group visit model integratingmedications, nutrition, and behavioral change to treat obesity.W.T. Donahoo and J.K. McGuire. Kaiser PermanenteColorado, Denver.550. EpigeneticsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A155 I 550.1 Characterization of the H4K16biomark in human lymphoid cells. L. Rios-Avila, S.S.K. Wijeratne,V. Pestinger and J. Zempleni. Univ. of Nebraska-Lincoln.A156 II 550.2 Identification of a potential roleof K9-biotinylated histone H3 in honeybee (Apis mellifera)development. R. Rodriguez Melendez, D-C. Bui, M.D. Ellis,R.M. Johnson and J. Zempleni. Univ. of Nebraska-Lincoln.146

sunday551. Nutritional Genomics and Regulationof Gene ExpressionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A157 I 551.1 Melissa officinalis essential oilreduces plasma triglyceride levels by downregulating SREBP-1c expression and the epigenetic modifications on SREBP-1ctarget genes. H-J. Jun, J.Y. Kim, S-Y. Cho, J. Jeun and S-J.Lee. Korea Univ.A158 II 551.2 Anti-inflammatory and metabolicmechanisms by which omega-3 fatty acids improve insulinresistance in high fat diet-induced obese mice. N.S.Kalupahana, K. Claycombe, T. Stewart, R. Hadidsaz, S.Booker, N. Siriwardhana and N. Moustaid-Moussa. Univ. ofTennessee, Knoxville and Michigan State Univ.A159 I 551.3 Genomic approach to evaluate theanti-obesity potential of (-)-hydroxycitric acid (HCA-SX). D.Bagchi, F.C. Lau, M. Bagchi and C.K. Sen. Univ. of HoustonCol. of Pharm., InterHlth. Res. Ctr., Benicia, CA and Ohio StateUniv. Med. Ctr.A160 II 551.4 miR-103 modulates G1/S transitionin IGF-1 stimulated mouse intestinal crypt cell proliferation. Y.Liao and B. Lonnerdal. Univ. of California, Davis.A161 I 551.5 A gel-based proteomic analysis ofgreen tea polyphenols effects on ovariectomized rats. C. Shao,L. Chen, C. Lu, C-L. Shen and W. Gao. Texas Tech Univ./TexasTech Hlth. Sci. Ctr.A162 II 551.6 Interaction of the pepsin resistant soyproteins to the intestinal mucosa of rat. M. Kong, J-W. Lee,S. Park, A. Lee and J.S. Kim. Kyungpook Univ., Republic ofKorea.A163 I 551.7 Effects of riboflavin deficiency onhepatic gene expression of rats. Y-T. Shih and F.L. Yang. FuJen Catholic Univ., Taiwan.552. Gene Variation on Nutrient MetabolismPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A164 I 552.1 Molecular cloning and characterizationof the human lactoferrin receptor gene promoter. R. Jiangand B. Lonnerdal. Univ. of California, Davis.A165 II 552.2 Two common variants in the humanCYP4F2 gene result in substantial alterations in vitamin E-whydroxylasespecific activity. S.A. Bardowell, D.E. Stec andR.S. Parker. Cornell Univ. and Univ. of Mississippi Med. Ctr.A166 I 552.3 A forward genetics approach toidentify genetic regulators of liver mineral accumulation in mice.R. McCreedy, L. Wang, M. Zhang, B.C. Jones, J. Beard andJ.C. Fleet. Purdue Univ. and Penn State.A167 II 552.4 Adaptation of bone and calciummetabolism to low dietary calcium stress is affected by geneticbackground in mice. R. McCreedy, A. Arges and J.C. Fleet.Purdue Univ.A168 I 552.5 Genotype-based online nutritionguidance. M. Kohlmeier. Univ. of North Carolina at ChapelHill.nutritionA169 II 552.6 Folate network genetic variation,plasma homocysteine, and global genomic methylation content.S.M. Wernimont, E.M. Smith, A.G. Clark, P.J. Stover, M.T.Wells, A.A. Litonjua, S.T. Weiss, J.M. Gaziano, K.L. Tucker,A. Baccarelli, J. Schwartz and P.A. Cassano. Cornell Univ.,Brigham and Women’s Hosp., USDA at Tufts Univ., IRCCSOMPoMaRe Fndn., Milan, Univ. of Milan and Harvard Sch. ofPubl. Hlth.A170 I 552.7 Single nucleotide polymorphisms inthe phosphatidylethanolamine N-methyltransferase gene mayinfluence choline requirement. K-A. da Costa, L. Fischer, H.M.Hwang and S.H. Zeisel. Univ. of North Carolina at Chapel Hilland Kannapolis.A171 II 552.8 The influence of glutathione-Stransferasepolymorphisms on the level of oxidative DNAdamage, antioxidant status and lipid profiles in healthy Koreanadults. H.R. Jo, H-J. Lee, J.H. Han, M.R. Cho, Y.K. Park, E.Park and M-H. Kang. Hannam Univ., Kyung Hee Univ. andKyungnam Univ., Republic of Korea.553. Carbohydrate Metabolism IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A172 I 553.1 Acute and chronic toxicity of d-allosein rats. T. Matsuo, Y. Iga, K. Nakamichi and Y. Shirai. KagawaUniv. and Natl. Inst. for Materials Sci., Ibaraki, Japan.A173 II 553.2 The effects of cooking, cooling andreheating on the glycemic index depends on potato variety. T.S.Kinnear and T.M.S. Wolever. Univ. of Toronto.A174 I 553.3 Effects of agave nectar versussucrose on weight gain, adiposity, blood glucose, insulin andlipid responses in mice. T. Nemoseck, S. Cole, Y. Petriskoand M. Kern. Sch. of Exercise and Nutr. Sci., San Diego StateUniv.A175 II 553.4 Effects of consumption of honey,sucrose and glucose on satiety and postprandial metabolism inhealthy subjects. T. Nemoseck, D. Cholish, Y. Petrisko and M.Kern. Sch. of Exercise and Nutr. Sci., San Diego State Univ.A176 I 553.5 Menstrual cycle affects postprandialglucose responses to a hyperlipidic meal in young adult women.I.L. Silva and A.G. Torres. Fed. Univ. of Rio de Janeiro.A177 II 553.6 Influence of honey versus sucrose onglucose, insulin and lipid responses in mice. T. Nemoseck, S.Cole, Y. Petrisko, M.Y. Hong and M. Kern. San Diego StateUniv.554. Energy and Macronutrient Metabolism IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A178 I 554.1 Postprandial energy availability withthree popular diets during weight maintenance after weightloss. C.O. Walsh, C. Ebbeling, J. Swain, H. Feldman andD. Ludwig. Harvard Med. Sch., Childrens Hosp. Boston andBrigham and Women’s Hosp.sun147

nutritionA179 II 554.2 Study of dietary reference intakesof protein for Chinese male youths with labeled leucine andlysine. X. Yang. Natl. Inst. of Nutr. and Food Safety, China CDC,Beijing.A180 I 554.3 Reproducibility of 24-hour energyexpenditure measured by whole-room indirect calorimetry inlean and obese males. K.D. Corbin, A.M. Knab, R.A. Shanely,D.C. Nieman and S.H. Zeisel. Univ. of North Carolina atChapel Hill, Kannapolis, Appalachian State Univ. and Univ. ofNorth Carolina at Chapel Hill.A181 II 554.4 No effect of a rapidly fermentable fiberon satiety in healthy subjects. J. Hess, A. Birkett, W. Thomasand J. Slavin. Univ. of Minnesota, St. Paul, GTC Nutr., Golden,CO and Sch. of Publ. Hlth., Univ. of Minnesota, Minneapolis.A182 I 554.5 Oxidation of energy substrates inrat brown adipose tissue. P. Xi, Z. Jiang, Z. Dai, X. Li, K. Yao,W. Jobgen, M.C. Satterfield and G. Wu. Guandong Inst. ofAnimal Sci., People’s Republic of China and Texas A&M Univ.A183 II 554.6 C57BL/6NHsd male mice started onhigh-fat diets at three, six, or nine weeks of age attain similarobesity phenotypes. J. Flowers and B. Mickelson. HarlanLabs. Inc., Madison, WI.555. Energy Balance, Macronutrient andWeight IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A184 I 555.1 The effect of dietary macrocompositionon weight loss and nonalcoholic fatty liver disease in bariatricsurgery candidates. V.E. Uhley, A. Neidert, J. Birkmeyer, J.F.Finks, C. Burant and E.A. Oral. Univ. of Michigan.A185 II 555.2 The effects of cocaine use on dietaryintake and BMI changes in HIV + adults. O. Lin, A. Campa,P. Johnson, T. Stewart, S. Sales and M.K. Baum. RobertStempel Col. of Publ. Hlth. and Social Work, Florida Intl. Univ.A186 I 555.3 Dietary intake, drug use andsymptomatology in HIV-infected individuals. I. Hatsu , A.Campa, S. Sales, P. Johnson, S. Lai and M.K. Baum. FloridaIntl. Univ. and Johns Hopkins Univ. Bloomberg Sch. of Publ.Hlth.A187 II 555.4 Hydration, nutrition, and energyexpenditure of female collegiate gymnasts at Southern UtahUniversity. M.C. Schmidt, S.E. Sorenson, A.R. Smailes andD.J. Snelling. Southern Utah Univ.A188 I 555.5 Using fitness devices and globalpositioning systems technology in measuring energyexpenditure and distance walked over flat and incline surfaces.R.G. Reed, M.I. Mosqueda, S.B. Going, B.J. Orr and N.Hongu. Univ. of Arizona.A189 II 555.6 How does the DRI and other predictionequations for energy intake compare to energy fed? E. Souza,N.L. Keim, S.H. Adams, J. Watson, S. Stoffel, D. Burnett, J.Blankenship and M.D. Van Loan. Univ. of California, Davisand USDA, Davis.A190 I 555.7 Chokeberry extract consumptioninhibits weight gain by modulating adipogenesis, insulinsignaling, and inflammatory related gene expression inadipose tissue in rats fed a fructose rich diet. B. Qin and R.A.Anderson. USDA, Beltsville, MD.sundayA191 II 555.8 Impact of a 16-week behavioral weightloss program on diet quality. E. Lee and K.H. Webber. Univ. ofKentucky.A192 I 555.9 Ingestion of deoxynivalenol reducesdiet-induced obesity in the mouse. B. Flannery, C. Amuzie, A.Ulrich, D. Romsos and J. Pestka. Michigan State Univ.556. LactationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A193 I 556.1 Toward understanding of disparitiesin exclusive breastfeeding. Y. Bai, S.M. Wunderlich and A.D.Fly. Montclair State Univ. and Indiana Univ.A194 II 556.2 A Mediterranean diet interventionrich in walnuts among lactating women: study design andbaseline characteristics. N.R. Stendell-Hollis, P. Thompson,M. Laudermilk, J. Winzerling, M. Daines and C. Thomson.Univ. of Arizona and Univ. Med. Ctr.A195 I 556.3 Prenatal supplements in thepostpartum period are effective in increasing breast milkdocosahexaenoic acid (DHA, 22:6n3) concentration. H.A.Durham, J. Salguero, E. Gilbert, A. Page, R.T. Tulley and C.J.Lammi-Keefe. LSU.A196 II 556.4 Breastfeeding practices in Mexico: ananalysis through four decades. M.E. Flores-Quijano and C.J.Echarri-Cánovas. Natl. Inst. of Perinatol., Mexico City and TheCol. of Mexico.A197 I 556.5 Infant feeding modifies the relationshipbetween rapid weight gain in infancy and childhood obesity. Z.Maalouf Manasseh, M.S. Kramer and K.G. Dewey. Univ. ofCalifornia, Davis and McGill Univ.A198 II 556.6 Practices of obstetricians regardingearly mother-to-newborn skin-to-skin contact, early initiation ofbreastfeeding and delayed cord clamping. K. Begum and K.G.Dewey. Univ. of California, Davis.A199 I 556.7 Anti-inflammatory, anti-oxidant, antimicrobialproperties of human milk-derived peptides. J.K. Frieland A. Tsopmo. Univ. of Manitoba.A200 II 556.8 The International Milk GenomicsConsortium web portal. D.G. Lemay, M.C. Lange, S.C. Crook,D.A. Sela, C. Lefèvre, P. Church, G. Pasin, M.A. Hauser,J.A.M. van Arendonk, D. Boichard, I.H. Mather, P.D. Martin,S.S. Moore, M.C. Neville, M. Rijnkels, K. Singh, C. Stanton,P. Williamson and J.B. German. Univ. of California, Davis,California Dairy Res. Fndn., Davis, Deakin Univ., Australia,Wageningen Univ., Netherlands, INRA, Jouy-en-Josas, Univ.of Maryland College Park, Univ. of Alberta, Univ. of ColoradoDenver, Aurora, USDA and Baylor Col. of Med.,A201 I 556.9 Site-specific evolution of caseinproteins. W.F. Martin, D.G. Lemay, M. Rijnkels and B. German.Univ. of California, Davis, USDA and Baylor Col. of Med. andNestlé Res. Ctr., Lausanne.A202 II 556.10 A low body mass index reduces humanmilk oligosaccharide concentration in breast milk of Bangladeshiwomen. C. Nissan, R. Sultana, S. El-Arifeen, R. Raqib and L.Bode. UCSD and ICDDR,B, Dhaka, Bangladesh.148

sundayA203 I 556.11 High cell plating density initiatesrapid self-assembly of multipotent mammary cells in threedimensionalbiomatrix. P.E. Hartmann, F. Hassiotou and E.Thomas. Sch. of Biomed., Biomolec. and Chem. Sci., Univ. ofWestern Australia.A204 II 556.12 Favorable views of breastfeedingbut misconceptions of recommendations in college studentstaking nutrition classes. A.M. Schroeder, R.S. Pobocik, N.S.Boudreau and D.J. Boardley. Bowling Green State Univ. andUniv. of Toledo.A205 I 556.13 Relations between diet intake andparenting stress in breastfeeding women. K. Butler, T. Kennedy,N. Aubuchon-Endsley, T. Valtr, R. Rudluff and D.G. Thomas.Oklahoma State Univ.A206 II 556.14 Dietary docosahexaenoic acid in aMidwestern donor milk population. C.J. Valentine, G. Morrow,A. Haban-Bartz, K. Collins, A. Hodge, M. Pennell, S. Weltyand L.K. Rogers. Ohio State Univ. and Nationwide Children’sHosp.A207 I 556.15 Development of an instrument tomeasure manager attitudes toward workplace breastfeedingsupport. T. Chow, I. Fulmer and B. Olson. Michigan StateUniv. and Georgia Tech.A208 II 556.16 Relationship of early infant feeding(breast versus formula) and fruit and vegetable variety in dietaryintake of 2-3 year olds. L.A. Strong, E. Strong, D. West, R.Brouwer, T. Ostbye and C. Lovelady. Univ. of North Carolinaat Greensboro and Duke Univ. Med. Ctr.A209 I 556.17 Some but not all breast-fed infantsbenefit from iron supplementation. J.K. Friel. Univ. ofManitoba.A210 II 556.18 Creatine synthesis: the origin ofcreatine in rat milk. S.G. Lamarre, E.E. Edisson, E.P. Wijekoon,M.E. Brosnan and J.T. Brosnan. Mem. Univ. of Newfoundlandand Univ. of Guelph, Canada.A211 I 556.19 Oligosaccharide diversity: bovineglycans through lactation. H.F. Yeung, S.S. Hua, E. DePeters,C.B. Lebrilla and J.B. German. Univ. of California, Davis.A212 II 556.20 A new HPLC-based method to profileand quantify human milk oligosaccharides from as little as 1uL milk. C. Nissan, N. Naidu, B. Choudhury and L. Bode.UCSD.A213 I 556.21 Concentration of milk-free fattyacids is increased during lactational mastitis. K.M. Hunt, J.E.Williams, M.K. Hunt, R. Ting, R. Behre, M.K. McGuire, B.Shafii and M.A. McGuire. Univ. of Idaho, Washington StateUniv., Moscow Family Med. and Gritman Med. Ctr., Moscow,ID.557. Medical/Nutrition EducationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A214 I 557.1 Compliance of energy and proteinintake correlates with changes in renal functions of patients withchronic kidney disease. M-E. Chen, S-J. Hwang, H-C. Chenand M-C. Huang. Kaohsiung Med. Univ. Hosp. and KaohsiungMed. Univ., Taiwan.A215 II 557.2 Validation of nutrition standardizedlanguage using Fehring model. P. Ritter-Gooder and N.M.Lewis. Univ. of Nebraska-Lincoln.nutritionA216 I 557.3 Tracking the effectiveness of variouscombinations of diet tips: results of the National Mindless EatingChallenge. R.W. Patterson, C.R. Payne and B. Wansink.Cornell Univ. and New Mexico State Univ.558. Community and Public Health NutritionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A217 I 558.1 Do knowledge and attitudes affectdietary behaviors in a population undergoing a radical transitionin food access, acquisition, and preparation? E.L. Mead, J.Gittelsohn, C. Roache and S. Sharma. Univ. of North Carolinaat Chapel Hill, Johns Hopkins Bloomberg Sch. of Publ. Hlth.and Dept. of Hlth. and Soc. Svcs., Govt. of Nunavut, Canada.A218 II 558.2 Iron deficiency and iron-deficiencyanemia among pregnant women in Kuwait. F. Ahmed and M.A.Al-Sumaie. Col. for Women, Kuwait Univ. and Ministry of Hlth.,Safat, Kuwait.A219 I 558.3 Milk intake and milk-related perceptionof Korean middle and high school students. K.J. Chang andW.I. Jung. Grad. Sch. of Educ., Inha Univ., Republic of Korea.A220 II 558.4 Attitudes and knowledge of fruit andvegetable recommendations among adults using the NationalCancer Institute Food Attitudes and Behaviors Survey. T.Erinosho, O. Thompson, R. Moser, L. Nebeling, F. Thompsonand A. Yaroch. NCI, NIH, Rockville and Ctr. for Human Nutr.,Omaha.A221 I 558.5 Child feeding behaviors of AsianIndian mothers. S.R. Momin and B.H. Olson. Michigan StateUniv.A222 II 558.6 Gestational weight gain knowledgeamong low-income pregnant Latinas. A. Hromi-Fiedler, A.Bermúdez-Millán, D. Chapman, S. Segura-Pérez, G. Damioand R. Pérez-Escamilla. Univ. of Connecticut, Connecticut NIHEXPORT Ctr. for Eliminating Hlth. Disparities among Latinos,Hispanic Hlth. Council, Hartford and Yale Sch. of Publ. Hlth.A223 I 558.7 Relationship between diabetesand bone health variables in adults with diabetes. G. NaseriKouzehgarani, T. Rogers and K. Chapman-Novakofski.Univ. of Illinois, Urbana.A224 II 558.8 A survey of pesticide use and safetypractices among farm-workers in Kentucky. F.N. Bebe and M.Panemangalore. Kentucky State Univ.A225 I 558.9 Prevalence of chronic healthconditions and risk factors among participants in a faith-basedhealth campaign. J. Hoy-Rosas and K.J. Lancaster. NYU.A226 II 558.10 The development of an interdisciplinarymodel to examine environmental factors on child healthand development. L.S. Brann and A. Krishnakumar. SyracuseUniv.A227 I 558.11 Responses to a health survey inpreparation for a cancer awareness and prevention program.N.L. Dawkins, V. Carter and B. Howard. Tuskegee Univ.A228 II 558.12 Job performance of school dietitianswas different than their percived job importance. J. Khil andH-K. Kim. Grad. Sch. of Educ., Honam Univ., Republic ofKorea.sun149

nutritionA229 I 558.13 Relationship of overweight-obesitywith some health conditions in women beneficiaries ofOportunidades, results of a national probabilistic survey. F.Mejia-Rodriguez, D. Quezada-Sanchez, T. Shamah-Levy andS. Villalpando-Hernandez. Natl. Publ. Hlth. Inst., Cuernavaca.A230 II 558.14 The effects of acculturation on thehealth status of Haitian-American mothers. J.M. Filemon, P.Chakraborty and A.K. Anderson. Univ. of Georgia.A231 I 558.15 Feeding practices of infants andtoddlers in the special supplemental nutrition program forwomen, infants and children in San Marcos, Texas. J. VonBank, H. van der Heijden, J. Rogers, S. Crixell and B.J.Friedman. Texas State Univ.A232 II 558.16 Food environment around recreationcenters in low-income neighborhoods of Baltimore City. L.Dennisuk, S.H. Lee, M. Rowan, S. Suratkar, K. Christiansen,S. Sharma and J. Gittelsohn. Johns Hopkins BloombergSch. of Publ. Hlth. and Univ. of North Carolina at Chapel Hill,Kannapolis.A233 I 558.17 Development of screening toolidentifying Korean adolescent females at Fe deficiency anemicstatus. S.Y. Park and S.M. Son. Catholic Univ., Republic ofKorea.A234 II 558.18 Food choices of Mexican high schoolstudents deviate from their perceptions of food healthiness. G.Rodriguez, S. Villalpando, B. Gaona, E.A. Frongillo and J.A.Rivera. Natl. Publ. Hlth. Inst., Cuernavaca and Univ. of SouthCarolina.A235 I 558.19 An apple a day? Factors associatedwith fruit and vegetable intake among African Americans inrural Texas. G. Curry, J.R. Sharkey and W.R. Dean. Sch. ofRural Publ. Hlth., Texas A&M Univ.A236 II 558.20 B12 vitamin And folate nutritionalstatus in Mexican children under five years old. L. Cuevas-Nasu, T. Shamah-Levy, S. Villalpando and I. Méndez Gómez-Humarán. Natl. Inst. of Publ. Hlth., Morelos, Mexico.A237 I 558.21 Overweight and obesity inOportunidades program beneficiary women. M.C. Morales-Ruán , L. Cuevas-Nasu, T. Shamah-Levy and I. Méndez.Natl. Publ. Hlth. Inst., Mexico City and Cuernavaca.559. Diet, Health and the EnvironmentPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A238 I 559.1 Comparison of dietary intake betweenfemale Vietnamese immigrants to Korea and Vietnamesefemales and immigrant’s sisters living in Haiphong, Vietnam.J-Y. Hwang, S.H. Kim, H.N. Choi, Y.A. Lee, H.W. Chung,T.T.P. Nguyet, N. Chang and W.Y. Kim. Ewha Womans Univ.,Republic of Korea and Hanoi Med. Univ., Vietnam.A239 II 559.2 Assessment of dietary intake in anInuvialuit population undergoing a rapid nutrition transition. X.Cao, E. Erber, E. DeRoose, L. Beck, J. Gittelsohn and S.Sharma. Univ. of North Carolina at Chapel Hill, Kannapolis,Dept. of Hlth. and Soc. Svcs., Govt. of Northwest Territories,Canadian Publ. Hlth. Assn., Inuvik and Johns Hopkins Univ.Bloomberg Sch. of Publ. Hlth.sundayA240 I 559.3 Inadequate diets in an Arcticpopulation undergoing a drastic environmental change. S.Sharma, B.N. Hopping, E.L. Mead, E. Erber, A. Buchan andC. Roache. Univ. of North Carolina at Chapel Hill and Dept. ofHlth. and Soc. Svcs., Govt. of Nunavut, Canada.A241 II 559.4 Prevalence and predictors of bodyimage discrepancy and dissatisfaction among Filipino youngadults. K.E. Branch, L.S. Adair and S. Agustin. Univ. of NorthCarolina at Chapel Hill and Univ. of San Carlos, Philippines.A242 I 559.5 Food frequency questionnaire testingin Puerto Rican children. A.M. Preston, C.A. Palacios, C.A.Rodriguez and R.M. Velez Rodriguez. Univ. Puerto Rico MedSci Campus.A243 II 559.6 Environmental and gender-relatedbarriers are limiting physical activity in Mexican public highschool students. G. Rodriguez, S. Villalpando, B. Gaona, E.A.Frongillo and J.A. Rivera. Natl. Publ. Hlth. Inst., Cuernavacaand Univ. of South Carolina.A244 I 559.7 Intakes of sugars, sodium, andpotassium through school lunch meals by elementary andjunior high school students. H-S. Lim and Y-R. Heo. ChonnamNatl. Univ., Republic of Korea.A245 II 559.8 Food insecurity in female Vietnamesemarriage immigrants in South Korea. H.N. Choi, Y.A. Lee, J-Y.Hwang, H.W. Chung, W.Y. Kim and N. Chang. Ewha WomansUniv. and Ewha Womans Univ. Sch. of Med., Republic ofKorea.A246 I 559.9 Negative nutrition impacts from thefood price crisis in Latin America. L. Iannotti and M. Robles.Washington Univ. and Intl. Food Policy Res. Inst., Washington,DC.A247 II 559.10 Are price changes adequate toproduce long-term dietary change: lessons from Russia’seconomic transition? J.E. Dellava and B. Popkin. Univ. ofNorth Carolina at Chapel Hill.560. Nutritional Epidemiology: Resultsfrom National Nutrition MonitoringData SetsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A248 I 560.1 Estimation of total antioxidant capacityin U.S. diet and dietary supplements. M. Yang, S-J. Chung,C.E. Chung, W.O. Song and O.K. Chun. Univ. of Connecticut,Kookmin Univ. and Ansan Col., Republic of Korea and MichiganState Univ.A249 II 560.2 Dietary total antioxidant capacity isinversely associated with the risk of cardiovascular disease inU.S. adults. M. Yang, S-J. Chung, C.E. Chung, W.O. Song andO.K. Chun. Univ. of Connecticut, Kookmin Univ. and AnsanCol., Republic of Korea and Michigan State Univ.A250 I 560.3 Nutritional contributions of pork to thediets of the U.S. population. L. Barraj, K. Smith, C. Scrafford,M. Murphy, J.S. Douglass, X. Bi and N. Tran. Exponent,Washington, DC.150

sundayA251 II 560.4 Phytonutrient intakes by adultsmeeting fruit and vegetable recommendations versus adultsnot meeting recommendations. M.M. Murphy, L.M. Barraj, J.S.Douglass, X. Bi, R. Cheatham, K. Randolph and D. Herman.Exponent, Washington, DC, Weber Shandwick, Chicago,Nutrilite Hlth. Inst., Buena Park, CA and UCLA Sch. of Publ.Hlth.A252 I 560.5 Intake of added sugars is notassociated with weight measures in children 6-to-18-years:NHANES 2003-2006. C.E. O’Neil, T.A. Nicklas, M. Zanovecand Y. Liu. LSU AgCtr., Baylor Col. of Med. and USDA,Houston.A253 II 560.6 Improved nutrient intake and dietquality associated with lean beef consumption in the U.S.:National Health and Nutrition Examination Survey 1999-2004.M. Zanovec, C.E. O’Neil, D.R. Keast, V.L. Fulgoni III andT.A. Nicklas. LSU AgCtr., Food & Nutr. Database Res. Inc.,Okemos, MI, Nutr. Impact LLC, Battle Creek, Baylor Col. ofMed. And USDA, Houston.A254 I 560.7 The relationship between whole grainconsumption and fiber intake in American adults: results fromNHANES 1999-04. A.M. Albertson and N.M. Holschuh.General Mills Inc., Minneapolis.A255 II 560.8 Usual folic acid intake and folatestatus in U.S. women aged 12-49 years, National Health andNutrition Examination Survey, 2001-2006. M. Cogswell, C.Pfeiffer, S. Tinker and R.J. Berry. Ctrs. for Dis. Control andPrevent.A256 I 560.9 Alcoholic beverage consumption byadults 21 years and over in the United States: results fromthe National Health and Nutrition Examination Survey, 2003-2004. S. Bowman, P.M. Guenther and J.D. Goldman. USDA,Beltsville, MD and Alexandria, VA.A257 II 560.10 Usual folic acid intake among U.S.women aged 15–44 years, NHANES, 2003–2006. S.C. Tinker,M.E. Cogswell, O.J. Devine and R.J. Berry. Ctrs. for Dis.Control and Prevent.561. Nutrition Epidemiology: Children andAdultsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A258 I 561.1 Participation of 1,725 fourth-gradechildren in the School Breakfast Program and National SchoolLunch Program: comparing study records to parental responseson consent forms. S.D. Baxter, J.A. Royer, A.J. Mackelprang,C.M. Devlin, C.H. Guinn and J.W. Hardin. Univ. of SouthCarolina.A259 II 561.2 Fruit juice consumption decreases theproportion of children with inadequate intakes of key nutrients:NHANES 2003-2006. M. Zanovec, V.L. Fulgoni III, C.E. O’Neiland T.A. Nicklas. LSU AgCtr., Nutr. Impact LLC, Battle Creek,Baylor Col. of Med. and USDA, Houston.A260 I 561.3 Improved nutrient intake and dietquality with 100% fruit juice consumption in children: NHANES2003-2006. C.E. O’Neil, V.L. Fulgoni III, M. Zanovec and T.A.Nicklas. LSU AgCtr., Baton Rouge, Nutr. Impact LLC , BattleCreek and Baylor Col. of Med., USDA.nutritionA261 II 561.4 Reproducibility regarding the age ofintroduction of complementary foods to infants as self-reportedby urban and rural low-income mothers in Guatemala. M.J.Soto, R. Campos, L. Hernández, M. Vossenaar and N.W.Solomons. CeSSIAM, Guatemala City.A262 I 561.5 Infant and early childhood feedingdifficulties are not associated with anorexia nervosa subtype.J.E. Dellava, M. Strober, L.M. Thornton, W. Kaye, C.M. Bulikand Genet. of. Consortium. Univ. of North Carolina at ChapelHill, UCLA and UCSD.A263 II 561.6 Do children and their parents eat asimilar diet? Association between child and parental dietaryintakes. Y. Wang, M. Beydoun, J. Li, Y. Liu and L.A. Moreno.Johns Hopkins Bloomberg Sch. of Publ. Hlth., NIA, NIH,Baltimore and Univ. of Zaragoza, Spain.A264 I 561.7 Autism linked to nutrition. R.J.Shamberger. King James Med. Lab., Cleveland.A265 II 561.8 Is protein intake associated with bonemineral density in young women? J.M. Beasley, L.E. Ichikawa,B.A. Ange, L. Spangler, A.Z. LaCroix, S.M. Ott and D.Scholes. Gp. Hlth. Res. Inst., Seattle, Fred Hutchinson CancerRes. Ctr., Arcadia Univ. and Univ. of Washington.A266 I 561.9 Alcohol in food during childhoodexposure as a risk factor for heavy drinking when adults: a casecontrolstudy in Europe. D. Gregori, M. Ghidina, G. Morpurgoand F. Zobec. Univ. of Padova and ZETA Res. Ltd., Trieste.A267 II 561.10 Greater fruit and vegetable intake isassociated with increased bone mass in older Puerto Ricans.S.N. Bhupathiraju, A.H. Lichtenstein, B. Dawson-Hughesand K.L. Tucker. Friedman Sch. of Nutr. Sci. and Policy, TuftsUniv. and USDA at Tufts Univ.A268 I 561.11 Dietary behaviors are associatedwith anxiety and depression of high school girls. S. Shin, K.N.Kwon, H. Kim and H. Joung. Grad. Sch. of Publ. Hlth., SeoulNatl. Univ.A269 II 561.12 Relationships among cognitivedietary restraint, subclinical ovulation disturbances, cortisoland 2-year change in bone density in premenopausal women.J.L. Bedford, J. Prior and S.I. Barr. Univ. of British Columbia.A270 I 561.13 Comparisons of dietary intakes andbody composition with sexual maturation among Korean girls.S. Jeong, S. Shin, K. Lee and H. Joung. Grad. Sch. of Publ.Hlth., Seoul Natl. Univ.A271 II 561.14 Magnesium intake and self-reportedhealth in pregnant women. C.J. Vance, D.W. Killilea and B.N.Ames. Wake Forest Univ. and Children’s Hosp. Oakland Res.Inst., CA.A272 I 561.15 Milk and milk product consumption inPoland. M. Schlegl-Zawadzka, A. Nowak, J. Hartwich and M.Rokitka. Jagiellonian Univ. Med. Col. and John Paul II Hosp.,Krakow.sun151

nutrition562. Nutritional Epidemiology: Biomarkersand ObesityPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A273 I 562.1 Carbohydrate analysis of highfructose corn syrup containing commercial beverages. P.N.Wahjudi, E. Hsieh, M.E. Patterson, C.S. Mao and W.N.P. Lee.Harbor-UCLA Med. Ctr.A274 II 562.2 Folate status, serum C-reactiveprotein level and gestational age: mothers and children’senvironmental health. H. Kim, J-Y. Lee, J-Y. Hwang, E-H.Ha, H. Park, M. Ha, Y. Kim, Y-C. Hong and N. Chang. EwhaWomans Univ., Col. of Med., Ewha Womans Univ., DankookUniv. Col. of Med., Ulsan Univ. Hosp., Univ. of Ulsan Col. ofMed. and Seoul Natl. Univ. Col. of Med., Republic of Korea.A275 I 562.3 Comparison of sodium and potassiumintake and excretion: results from the AMPM validation study.D.G. Rhodes, J.C. Clemens, T. Murayi and A. Moshfegh.USDA, Beltsville, MD.A276 II 562.4 Bone mineral density, urinary sodium,and urinary calcium in healthy young Asian and Caucasianwomen. S.I. Barr and J.L. Bedford. Univ. of British Columbia.A277 I 562.5 Caffeine exposure biomonitoring:correlation and variability of urinary caffeine metabolites. C-I.Pao, M.E. Rybak and C.M. Pfeiffer. Battelle Mem. Inst., Atlantaand Ctrs. for Dis. Control and Prevent.A278 II 562.6 Association of 25-hydroxyvitamin Dwith lung function in the Health, Aging and Body CompositionStudy. B.J. Reardon, S.B. Kritchevsky, T. Harris, D.K.Houston, D. Bauer, A. Koster, A. Newman and P.A. Cassano.‘Cornell Univ., Wake Forest Univ. Med. Ctr., NIA, NIH, UCSFand Univ. of Pittsburgh.A279 I 562.7 Urinary phytoestrogen biomarkersin the U.S. population: findings from the National Health andNutrition Examination Survey (NHANES 1999–2004). M.E.Rybak, R.B. Jain and C.M. Pfeiffer. Ctrs. for Dis. Control andPrevent.A280 II 562.8 Weight change patterns in Mexicancollege student applicants. M. Teran-Garcia, Y. Wang, C.Aradillas-Garcia, F.C. Drumon Andrade and UPAMIGOSgroup. Univ. of Illinois at Urbana-Champaign and AutonomousUniv. of San Luis Potosi, Mexico.A281 I 562.9 Racial differences in fasting lipids: lowlevels of triglycerides in overweight and obese nonHispanicBlack women. M. McIntosh, C.J. Kalynych, C. Vukich, M. Lottand R.H. Lerman. Univ. of Florida Col. of Med. Jacksonvilleand MetaProteomics LLC, Gig Harbor, WA.A282 II 562.10 Obesity is higher in male than femaleadolescents in Guadalajara, Mexico. E.M. Vasquez-Garibay,C.L. Gutierrez-Ruvalcaba, E. Romero-Velarde and R. Troyo-Sanroman. Univ. of Guadalajara, Mexico.A283 I 562.11 Estimation of adiposity inschoolchildren of Guadalajara, Mexico. E.M. Vasquez-Garibay,L.E. Romo-García, B. Vizmanos and A. Larrosa-Haro. Univ.of Guadalajara, Mexico.A284 II 562.12 Fish consumption and the prevalenceof obesity, type 2 diabetes, and hypertension among women ofchildbearing age: analysis of 2003-2006 NHANES data. S.S.Jones, M.R.C. Greenwood and S. Zidenberg-Cherr. Univ. ofCalifornia Davis Hlth. Systs., Sacramento, Univ. of California,Davis and Univ. of Hawaii.sunday563. Innovative Diet AssessmentTechnologies and Measurement ErrorMethodologies IIPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A285 I 563.1 Comparison of body compositionby bioelectrical impedance analysis and dual-energy X-rayabsorptiometry in Hispanic diabetics. M. Batech, W.L. Beeson,E. Schultz, L. Salto, A. Firek, M. DeLeon, H. Balcazar and Z.Cordero-MacIntyre. Schs. of Publ. Hlth. and Med., Loma LindaUniv. and Sch. of Publ. Hlth., Univ. of Texas at El Paso.A286 II 563.2 Comparison of intervieweradministered24-hour recalls with web-based assessment.L. Arab, A. Winter, A. Gammelgard, J. Shapiro and S.Thompson. David Geffen Sch. of Med. at UCLA, UCLA andSantech Inc., La Jolla.A287 I 563.3 Socioeconomic status and measuresof dietary recall accuracy for fourth-grade children. S.D. Baxter,C.H. Guinn, J.A. Royer, J.W. Hardin, A.J. Mackelprang, C.M.Devlin and A.F. Smith. Univ. of South Carolina and ClevelandState Univ.A288 II 563.4 Meat, poultry and fish consumption bycooking method and degree of doneness. N.L. Tran, L. Barrajand X. Bi. Exponent, Washington, DC.A289 I 563.5 Cultural adaptations in the collectionand entry of dietary intake data: field experiences with Latinowomen. E. Pinto, P. Rojas, M. De La Rosa and G. Rahill. Univ.of Puerto Rico, Río Piedras Campus, Florida Intl. Univ. andArkansas State Univ.A290 II 563.6 Development and validation ofa photographic method to assess dietary intake in youth.T.B. Matthiessen, F.M. Steinberg and L.L. Kaiser. Univ. ofCalifornia, Davis.A291 I 563.7 Determining the accuracy of a quickquestionnaire in assessing calcium intake in young healthywomen. C.W. Gunther, D. Teegarden and J.A. Shertzer. OhioState Univ. and Purdue Univ.A292 II 563.8 Adjusting serum biomarkers of folatestatus for within-person variation. R. Bailey, A. Carriquiry, J.Gahche, K. Dodd, M. Joseph, J. Dwyer, E. Yetley, C. Semposand M.F. Picciano. OD, NIH, Iowa State Univ. and Natl. Ctr. forHlth. Stats., Hyattsville, MD.564. Nutritional Interventions for HealthPromotionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-1:45 p m (I); 1:45 p m-2:45 p m (II)A293 I 564.1 Sex differences in response to aMediterranean diet on cardiovascular risk profile. A. Bédard, M.Riverin, S. Dodin, L. Corneau and S. Lemieux. Univ. Laval,Canada.A294 II 564.2 Effects of nuts on glycemic control andcoronary heart disease risk factors in type 2 diabetes. C.W.C.Kendall, A. Esfahani, T.L. Parker, M.S. Banach, S. Mitchelland D.J.A. Jenkins. Univ. of Toronto and St. Michael’s Hosp.152

sundayA295 I 564.3 The effect of adding monounsaturatedfat to a dietary portfolio of cholesterol-lowering foods inhypercholesterolemia. C.W.C. Kendall, L. Chiavaroli, J.M.W.Wong, A. Esfahani and D.J.A. Jenkins. Univ. of Toronto andSt. Michael`s Hosp.A296 II 564.4 Watermelon supplementation reducesaortic blood pressure and wave reflection in individuals withpre-hypertension and stage 1 hypertension. A. Figueroa, M.A.Sanchez-Gonzalez, F. Viicl and P. Perkins-Veazie. FloridaState Univ. and North Carolina State Univ., Kannapolis.A297 I 564.5 Dried plums consumed twice dailyincrease antioxidant capacity after two weeks in adult women.S. Kaper, L.S. Howarth, Y. Petrisko, A. Furchner-Evanson,T. Nemoseck, M.Y. Hong and M. Kern. Sch. of Exercise andNutr. Sci., San Diego State Univ.A298 II 564.6 Strategies to remediate vitamin Ddeficiency in Mongolian children. D. Ganmaa, N. Sumberzul,M. Holick, W. Willett, L. Frazier and J. Rich-Edwards. HarvardSch. of Publ. Hlth., Hlth. Sci. Univ. of Mongolia, Boston Univ.Sch. of Med. and Brigham and Women’s Hosp., Harvard Med.Univ.A299 I 564.7 The effect of mixed fruit and vegetableconcentrates on biomarkers of cardiovascular disease: a reviewof the clinical evidence. A. Esfahani, J. Truan, K. Srichaikuland C.W.C. Kendall. Univ. of Toronto and St. Michael’s Hosp.A300 II 564.8 The Global Positioning Systemnutritional drawing courses: promoting physical activity andgood nutrition through popular technology. N. Hongu, J.K.Larsen, R.R. Thornton, K.D. Wisneski and B.J. Orr. Univ. ofArizona.A301 I 564.9 Dietary changes in men and womenwith type 2 diabetes mellitus: a pilot study assessing the impactof a novel, simplified approach to diet guidance. K.H. Rubin,N.V. Matusheski, K.C. Maki, M.R. Rubin, M.S. Reeves, V.N.Kaden and R.M. Black. Kraft Foods Inc., Glenview, IL andProvident Clin. Res., Glen Ellyn, IL.A302 II 564.10 Peer education initially helps preventweight changes in freshman women. D.D. Guest, M.P. Thorpe,M.C. Mojtahedi, A. Richey, E. Mailey, L.E. Kedem, E. McAuley,K. Chapman-Novakofski and E.M. Evans. Univ. of Illinois,Urbana.A303 I 564.11 Weight change in young adults:identifying factors for targeted intervention strategies. J.M.Rueda, E. Doko, K. Lanni and P. Khosla. Wayne State Univ.A304 II 564.12 Promoting healthier vendingmachines on a college campus. J.L. Lapp, W. Ressler and A.Frith. Ithaca Col.A305 I 564.13 Effect of strawberry powder onblood pressure and flow-mediated vasodilation in individualswith prehypertension. A. Vaux-Bjerke, F. Kan, T. Barrette, I.Edirisinghe, B. Burton-Freeman and T. Kappagoda. Univ. ofCalifornia, Davis and Illinois Inst. of Technol., Summit-Argo.nutritionA306 II 564.14 A home-based educationalintervention to caregivers in South India to improvecomplementary feeding and responsive feeding, andpsychosocial stimulation increases dietary intake, growthand development of infants. M.E. Bentley, S. Vazir, P. Engle,N. Balakrishna, S. Johnson, H. Creed, P. Griffiths and S.F.Rao. Univ. of North Carolina at Chapel Hill, Natl. Inst. Nutr.,Hyderabad, India, California Polytech State Univ. San LuisObispo, Univ. of Denver, Aurora, Inst. Nutr. Res., Lima, Peruand Univ. of Loughborough, UK.A307 I 564.15 Impact of the Mediterranean diet andweight loss on plasma cell adhesion molecule concentrationsin men with the metabolic syndrome. C. Richard, C. Couillard,M-M. Royer, S. Desroches, P. Couture and B. Lamarche.Laval Univ., Canada.A308 II 564.16 Effect of almond consumption on theserum fatty acid profile: a dose response study. C.W.C. Kendall,S. Nishi, A-M. Yoon, A. Esfahani, R.P. Bazinet, K.G. Lapseyand D.J.A. Jenkins. Univ. of Toronto and St. Michael’s Hosp.and Almond Board of California, Modesto.A309 I 564.17 Effects of acute and chronic processedtomato intake on LDL oxidation and paraoxonase activity. Y.Cao, P.M. Kris-Etherton and B.M. Burton-Freeman. PennState, Univ. of California, Davis and Illinois Inst. of Technol.,Moffet Campus.A310 II 564.18 Effects of peanut and peanut butterconsumption on waist circumference and body weight in adultswith type 2 diabetes. K. Reinsma, L. Heim, M. Wien, K. Odaand J. Sabaté. Loma Linda Univ.A311 I 564.19 Comparison of effects of live- anddead cell from potential probiotic lactic acid bacteria. N.J. Ha,D.K. Lee, M.J. Kim, J.R. Kim, M.K. Cha, J.Y. Kang, S.A. Kimand H.S. Shin. Col. of Pharm., Sahmyook Univ. and Col. ofPharm., Duksung Women’s Univ., Republic of Korea.A312 II 564.20 Blueberries reduce lipid peroxidationand boost antioxidant enzymes in apoE knockout mice. X.Wu, J. Kang, C-h. Xie, M.E. Ferguson, T.M. Badger and S.Nagarajan. Univ. of Arkansas for Med. Sci.A313 I 564.21 Effect of cinnamon on postprandialglucose. C.B. Wright, S. Calder and L. Humphries. SouthernUtah Univ.A314 II 564.22 Reductions in 24-hour glucose, bloodpressure and body weight in men and women with type 2diabetes mellitus: a pilot study assessing the impact of a novel,simplified approach to diet guidance. K.C. Maki, K.H. Rubin,N.V. Matusheski, M.R. Rubin, M.S. Reeves, V.N. Kaden andR.M. Black. Provident Clin. Res., Glen Ellyn, IL and Kraft FoodsInc., Glenview, IL.A315 I 564.23 Novel dietary intervention producessignificant improvements in fibromyalgia patients with irritablebowel syndrome. K.F. Holton, D.L. Taren, R.M. Bennett andK.D. Jones. Sch. of Nursing, Oregon Hlth. & Sci. Univ. and Sch.of Publ. Hlth., Univ. of Arizona.sunPOSTER PRESENTERS: UPLOAD YOUR POSTERWhere: E-Poster Counter, Hall C LobbyDeadline: Wed., April 28, 3:30PMUploaded posters will be available online to all registered attendees following the meeting atwww. experimentalbiology.org153

pathologysundayPathology565. Cell Death, Tissue Injury and RepairPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 11:30 a m-1:30 p mA323 565.1 Role of E74-like transcription factor-3 in thepulmonary regenerative response to naphthalene-inducedbronchiolar epithelial injury. J.R. Oliver and J. Hu. Hosp. forSick Children and Univ. of Toronto.A324 565.2 The effects of irridation on glioblastomacell lines: a potential tool to study the mechanism of tumorresistance. C-I. Sze, C-L. Hsieh, R. Tsai, J. Sze, Y-F. Huangand S-Y. Ho. Natl. Cheng Kung Univ. Med. Col. and SinlauHosp., Taiwan.A325 565.3 Pro-apoptotic effects of retinoic acid onactivated canine neutrophils. S. Channabasappa, S. Stewart,S. Caldwell, A. Carr and B. Singh. Univ. of Saskatchewan andCol. of Arts and Sci., Saskatoon.A326 565.4 Repair and regeneration in a Giant Danio(Danio aequipinnatus) model of heart injury. P.J. Lafontant,A.R. Burns, J. Grivas, M.A. Lesch, T. Frounfelter, B.L.Golden, N. Fitzharris and B. Nida. DePauw Univ. and Univ. ofHouston Col. of Optom.A327 565.5 Bowel morphologic evaluation in experimentaladministration of an extract of Ocimum champechianum. A.P.Gurgel, K.P. Cavalcanti, T. Mendes, P. Barreto, I.A. Souza,N.T. Filho and A.S. Cabrita. Univ. of Coimbra, Portugal andFed. Univ. of Pernambuco, Brazil.A328 565.6 Integrin alpha 7 interacts with HtrA2 to induceprostate cancer cell death. J-H. Luo, Z-H. Zhu and Y.P. Yu.Univ. of Pittsburgh.A329 565.7 Inhibition of polyisoprenylated proteinmetabolism may explain the apoptotic properties of farnesoland related flavors. L.T. Ayuk-Takem, F. Amissah and N.S.Lamango. Florida A&M Univ.A330 565.8 Analysis of cell cycle, cell death and EGFRexpression in hepatic cells WRL68 treated with ethanol. E.Alvarez-Ayala, J. Reyes-Esparza and L. Rodriguez-Fragoso.Univ. Autónoma del Estado de Morelos, Mexico.A331 565.9 Acrylamide-induced apoptosis in macrophages:anti-apoptotic role of ATF3. K. Kim, E. Sohn, D.K. Rhee and S.Pyo. Sungkyunkwan Univ. and Kangwon Natl. Univ., Republicof Korea.A332 565.10 Apoptosis in b-catenin knockout mice occursthrough the Fas pathway. K.N. Nejak-Bowen, X. Tan, C. Daiand S. Monga. Univ. of Pittsburgh.A333 565.11 Mouse genotype alters palatal fusion responseto nicotine. M.J. Serrano and K. Svoboda. Baylor Col. ofDent.A334 565.12 Polonium-210 in diesel particulate matter. G.I.Lykken, R. Czapiewski and T. Ward. Univ. of North Dakotaand Techsource Inc., Germantown, MD.A335 565.13 Investigating a 3-step leukemogenic hypothesisin C57BL/6 mice: tungsten, RSV and hypoxia. C.D. Fastje,K. Harper, C. Terry, S.S. Wong and M.L. Witten. Univ. ofArizona.A336 565.14 Tobacco smoke-induced lung lesions persistpostexposure in spontaneously hypertensive rats. D.W. Wilson,C. TeeSy, H-P. Witschi and K. Pinkerton. Univ. of California,Davis.A337 565.15 Human intestinal ischemia/reperfusioninducedinflammation characterized: experiences from a newtranslational model. K. Lenaerts, J. Grootjans, J.P.M. Derikx,R.A. Matthijsen, A.P. de Bruïne, A.A. van Bijnen, R.M. vanDam, C.H.C. Dejong and W.A. Buurman. Maastricht Univ.Med. Ctr. and VieCuri Med. Ctr., Netherlands.A338 565.16 Pentoxifylline ameliorates acute renal ischemiareperfusioninjury. J.P. Grande, J. Cheng and P. Yin. MayoClin.A339 565.17 Differences in cutaneous mast cells affect scarformation. B.C. Wulff, A.E. Parent, M.A. Meleski and T.A.Wilgus. Ohio State Univ.A340 565.18 Ultrastructural differences in the endoplasmicreticulum among various pituitary tumor types. S. Sharma, F.Rotondo, K. Kovacs and E. Horvath. St. Michael’s Hosp.,Toronto.A341 565.19 Expression profiling of intestinal ischemia/reperfusion: first human in vivo findings. K. Lenaerts, J.Grootjans, J.P.M. Derikx, R.M. van Dam, C.H.C. Dejong andW.A. Buurman. Maastricht Univ. Med. Ctr., Netherlands.566. Breast Cancer: From Bench to BedsidePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 11:30 a m-1:30 p mA342 566.1 Coordinate dysregulation of multiplemicroRNAs that regulate DNMT3b expression characterizes asubset of basal-like breast cancers. R. Sandhu, C.A. Livasyand W.B. Coleman. Univ. of North Carolina at Chapel Hill.A343 566.2 Mitochondrial p53/Bid interaction plays a proapoptoticrole in response to PPARrg and RXR ligands in breastcancer cells. D. Bonofiglio, E. Cione, D. Vizza, M. Perri, A.Pingitore, H. Qi, S. Catalano, M.L. Panno, G. Genchi and S.Andò. Univ. of Calabria, Italy.A344 566.3 Inhibition of cyclin D1 expression by androgenreceptor in breast cancer cells: identification of a novelandrogen response element. M. Lanzino, D. Sisci, C. Morelli,S. Catalano, I. Casaburi, C. Capparelli, P. Avena and S.Andò. Univ. of Calabria, Italy.A345 566.4 Role of Nrf2/antioxidant response element inmammary carcinogenesis. L. Becks, M. Prince, H. Burson, C.Christophe, K. Itoh, M. Yamamoto, E. Orchard, J. McLarty,S. Zhang and H.E. Kleiner-Hancock. LSU Hlth. Sci Ctr.,Shreveport, Feist-Weiller Cancer Ctr., Shreveport, HirosakiUniv. Sch. of Med. and Tohoku Univ. Grad. Sch. of Med.,Japan,.A346 566.5 Development and characterization of cell linesderived from hamster breast carcinomas as model of oncolyticvirotherapy. H.E. Kleiner-Hancock, M. Coburn, S. Zhang, B.Cheng, L. Li, M. Lowery-Nordberg, B.D.L. Li and J.M. Mathis.LSU Hlth. Sci. Ctr. and Feist-Weiller Cancer Ctr., Shreveport.A347 566.6 Proteomic analysis identifies differentiallyexpressed proteins in a breast primary tumor and associatedbone metastatic lesion. V. Castronovo, B. Dumont, A. Turtoi,Y. Greffe, Y.H. Wang and A. Bellahcene. Univ. of Liege,Belgium.154

sundayA348 566.7 Annexin A1 and cytostatic effects of HDACinhibitors on breast adenocarcinoma cell line, MCF7. A. Hirata,T. Senanayake, P.M. Woster and F. Hirata. Wayne State Univ.Eugene Applebaum Col. of Pharm. and Hlth. Sci.A349 566.8 O-GlcNAc causes increased levels of tumorsuppressor protein p53 in human breast cancer MCF-7 cells.K. Wang, S-R. Ho and A. Paterson. Univ. of Alabama atBirmingham.A350 566.9 Fatty acid composition changes in humanMCF-7 breast adenocarcinoma cells following anti-estrogentreatments. S. St.-Pierre and M.E. Surette. Univ. of Moncton,Canada.A351 566.10 Stathmin expression in breast cancer patientstreated with anti-tubulin drugs. T-W. Lu, K. Beedupalli, W.Johnson, R. Luduena and I-T. Yeh. Univ. of Texas Hlth. Sci.Ctr. at San Antonio.A352 566.11 Pathologic changes in breast cancer after antiestrogentherapy. N. Samarnthai, R. Elledge, J. Huang, S.Massarweh and I-T. Yeh. Univ. of Texas Hlth. Sci. Ctr. at SanAntonio, Baylor Col. of Med. and Univ. of Kentucky.567. Lung CancerPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 11:30 a m-1:30 p mA353 567.1 Nicotine upregulates the expression of alpha-7-nicotinic receptors on human non-small cell lung cancer cellsvia alpha-7-nAChRs and protein kinase C sensitive mechanism.J.K. Lau, K.C. Brown and P. Dasgupta. Marshall Univ. Sch. ofMed.A354 567.2 A strong inverse correlation between p16INK4aand pRb expression is observed at the level of individual tumorcells in HPV-negative primary squamous cell lung cancer. J.H.Suh and K.R. Shroyer. Stony Brook Univ. Med. Ctr.A355 567.3 Sirtuin expression is downregulated in nonsmallcell lung cancer. Q.R. Xie, Z. Li, Z. Chen, S. Lu, W. Yingand W. Xia. Shanghai Jiao Tong Univ. and Shanghai ChestHosp.A356 567.4 Capsaicin: a potential therapeutic agent forhuman small cell lung cancer. A.M. Dom, K.C. Brown, T.R.Witte, W.E. Hardman and P. Dasgupta. Marshall Univ. Sch. ofMed.A357 567.5 Capsaicin displays anti-proliferative activityof human small cell lung cancer via recruitment of E2F4 todownstream target genes. P. Dasgupta, K.C. Brown, T.R.Witte, H. Luo, W.E. Hardman and Y.C. Chen. Marshall Univ.Sch. of Med. and Alderson Broaddus Col., WV.A358 567.6 Akt regulates Raf/MEK/ERK cascade, VEGFand matrix metalloproteinase expression, and malignantcharacteristics of NSCLC cells. K. Jiang, S. Rice, T. Sharp, J.Qi, D. Mu, B. Han and D.S. Zander. Penn State Hershey Med.Ctr.568. NeuropathologyPosterpathologySu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 11:30 a m-1:30 p mA359 568.1 Autonomous myotube fate specificationmediated by Egr3 transcriptional regulation in muscle stretchreceptor morphogenesis. M. Oliveira Fernandes, K. Grunerand W. Tourtellotte. Northwestern Univ., Chicago.A360 568.2 Egr3 is a transcriptional regulator required fornormal target tissue innervation during sympathetic nervoussystem development. D.H. Quach, L. Li, L. Eldredge, A.Honasoge, K. Gruner and W. Tourtellotte. NorthwesternUniv., chicago.A361 568.3 Mucopolysaccharidosis type IIIB and GalNActransferase double knockout mice manifest early onset fatalleukodystrophy. E.M. Whitley, E.M. Snella, A.D. Dierenfeld,F.D. Echevarria and N.M. Ellinwood. Iowa State Univ.A362 568.4 Nitric oxide prevents cognitive disorders andneurodegeneration in rats with experimental Alzheimer’sdisease. E.B. Manukhina, A.V. Goryacheva, I.V. Barskov,M.G. Pshennikova, N.A. Andrianov, H.F. Downey and I.Y.Malyshev. Inst. of Gen. Pathol. and Pathophysiol., Moscow,Univ. of North Texas Hlth. Sci., Sci. Ctr. of Neurol., Moscow andMoscow State Univ. of Med. and Dent.A363 568.5 miRNA expression patterns during skeletalmuscle regeneration. Y. Chen, J. Gelfond, L.M. McManus andP.K. Shireman. Univ. of Texas Hlth. Sci. Ctr. at San Antonio andSouth Texas Veterans Hlth. Care Syst.A364 568.6 Rab7 CMT2B mutants alter function inendosomal transport, growth factor signaling and regulatoryprotein interaction. P. Jim, S. Mukherjee, S. Basuray, E.Romero, C. Contreras and A. Wandinger-Ness. Univ. of NewMexico.A365 568.7 YKL-40 glial expression may impact neuronaltrophic support in neurodegeneration and neurologicalconditions. D. Bonneh-Barkay, M. Figley, H. Zou, A. Starkey,W. Wang, S. Bissel, A.K. Wagner and C.A. Wiley. Univ. ofPIttsburgh.A366 568.8 AAV-mediated sFLT-1 gene therapy amelioratesretinal lesions in Ccl2/Cx3cr1 deficient mice. J. Tuo, J-J. Pang,X. Cao, D. Shen, J. Zhang, A. Scaria, S.C. Wadsworth, P.Pechan, W.W. Hauswirth and C-C. Chan. NEI, NIH, Univ. ofFlorida and Genzyme Corp., Framingham, MA.A367 568.9 Retinoid receptor-mediated signaling in motorneurons and its implications for amyotrophic lateral sclerosis.C.L. Kolarcik and R. Bowser. Univ. of Pittsburgh Sch. of Med.A368 568.10 Post-translational protein modifications oftransthyretin in amyotrophic lateral sclerosis. C.L. Kolarcik, J.Ganesalingam, S.W. Darko, J. An, D. Lacomis and R. Bowser.Univ. of Pittsburgh Sch. of Med. and King’s Col. London.A369 568.11 Cystatin C: expression and activity inamyotrophic lateral sclerosis. M.E. Wilson, I. Boumaza, D.Lacomis and R.P. Bowser. Univ. of Pittsburgh.A370 568.12 Prion disease prevention: mapping genetictransmission etiology. A.C. Kelly, N. Mateus-Pinilla, M. Douglas,M. Douglas, M. Ruiz, W. Brown, T. Beissel, P. Shelton and J.Novakofski. Univ. of Illinois at Urbana -Champaign and IllinoisDept. of Nat. Resources, Springfield.A371 568.13 Functional evaluation of a 3-D nerve constructutilized for repair of a critical nerve defect. A.M. Adams, T.Y.Kostrominova and L.M. Larkin. Univ. of Michigan and IndianaUniv. Sch. of Med. Northwest, Gary.155sun

pathology/PharmacologyA372 568.14 Overexpression of human Down syndromecandidate region 1 gene is protective in stroke. C.G. Sobey, V.H.Brait, K. Martin and M.A. Pritchard. Monash Univ., Australia.A373 568.15 Microglia/macrophages and gliomaprogression. H. Zhai, I. Gravanis and S. Tsirka. Stony BrookUniv., SUNY.A374 568.16 Pharmacogenetic testing in the pediatricepileptic population. T. Sander, C.J. Marcuccilli, T. Zembles,R.N. Hines, S. Lo and P.E. North. Med. Col. of Wisconsin andChildren’s Hosp. of Wisconsin.sundayA375 568.17 Protein biomarkers for motor neuron disease.R.P. Bowser, J. An and J. Ganesalingam. Univ. of PittsburghSch. of Med. and Kings Col. London.A376 568.18 Scedosporium apiospermum presenting as anintracranial mass in an immuno-compromised patient. A. Dabi,M. Kurukumbi, R. Khan and A. Jayam-Trouth. Howard Univ.Hosp.Pharmacology and Experimental Therapeutics569. Diabetes PharmacologyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC1 569.1 The effect of a human pancreatic a-amylaseinhibitor, montbretin A, on the chronic treatment of type 2diabetes. V.G. Yuen, G. Brayer, S. Withers, R. Andersen, J.Coleman and J. McNeill. Univ. of British Columbia and Ctr. forDrugs R&D, Vancouver.C2 569.2 ACE 2: a potential therapeutic target forangiotensin II-mediated insulin resistance and glucoseintolerance. K.H. Chhabra, H. Xia and E. Lazartigues. LSUHlth. Sci. Ctr., New Orleans.C3 569.3 Phosphatidylcholine supplementation alleviatesthe impaired glucose response induced by acutemethionine loading. A-l.N. Lopez, M.D. Gossell-Williams,O.R. Simon and H. Phillips. Univ. of West Indies, Jamaica.C4 569.4 Antidiabetic potential of combine aqueousextract of Eugenia jambolana and >Momordica charantia fruit.S.U. Yele. Sch. of Pharm. and Technol. Mgmt., NMIMS Univ.,India.C5 569.5 Amelioration of STZ-induced type I diabeticnephropathy in rats by a phytomedicine: Gmelina arborea. Y.A.Kulkarni and A. Veeranjaneyulu. Sch. of Pharm. & Technol.Mgmt., SVKM’s NMIMS Univ., India.C6 569.6 Antioxidant defense in renal proximal tubularcells from normal and diabetic rats. L.H. Lash, D.A. Putt, S.R.Terlecky and Q. Zhong. Wayne State Univ. Sch. of Med.570. Obesity and Metabolic SyndromePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC7 570.1 Effect of l-carnitine intake on tolerance tophysical exercise, oxidative stress and vascular reactivityin obese trained rats. F.B.M. Priviero, J. Rojas-Moscoso,R. Gómez-Campos, C. Valgas da Silva, E.M. Carneiro, E.Antunes and A. Zanesco. UNICAMP, Univ. Estadual deCampinas and UNESP, Rio Claro, Brazil.C8 570.2 L-4F rescues the metabolic syndromephenotype of HO-2 null mice via insulin, adiponectin, andLKB1 signaling pathways. K.R. Angevine, A.P.H. Burgess, L.Vanella, D.H. Kim, K. Sodhi, S.J. Peterson, N.G. Abrahamand E. Mensah-Osman. Univ. of Toledo Col. of Med. and NewYork Med. Col.C9 570.3 Endothelium-dependent contractions inducedby aging and diet-induced obesity are attenuated in lipocalin-2deficient mice. J.T.C. Liu, A. Xu, R.Y.K. Man, T.W. Mak, I.K.M.Law, C.F. Liang, P.M. Vanhoutte and Y. Wang. Univ. of HongKong and Ontario Cancer Inst., Toronto.C10 570.4 Transgenic expression of CyP7A1 in the liverprevents high fat diet-induced obesity and insulin resistance inmice. T. Li, E. Owsley, M. Matozel, P. Hsu and J.Y.L. Chiang.Norheastern Ohio Univs. Col. of Med.C11 570.5 Effect of pioglitazone, simvastatin and theircombination on adiponectin and TNF-a level in the metabolicsyndrome: novel findings from the high fructose-fed rat model.N.N. Nassar and M.F. Schaalan. Fac. of Pharm., Cairo Univ.and Fac. of Pharm., Misr Intl. Univ., Egypt.C12 570.6 Age-associated decline in erectile function: theconfounding influence of obesity. M.T. Maio, M. Komolova, C.Smallegange and M.A. Adams. Queen’s Univ., Canada.C13 570.7 Obesity decreases the activity of the vascularendocannabinoid system: role of eNOS and AMPK. N. Lobato,F. Filgueira, F. Giachini, M.H. Carvalho, R.C. Webb, R.C.Tostes and Z. Fortes. Univ. of São Paulo and Med. Col. ofGeorgia.C14 570.8 Improvement of blood rheology by productGRTC in a metabolic syndrome aging model. J. Yang, N. Tan, Y.Zhang, C. Zhao and J-S. Zhu. Pharmanex Beijing Pharmacol.Ctr., Pharmanex Res. Inst., Provo, UT and Sch. of Pharm.,Xinjiang Shihezi Univ., People’s Republic of China.571. Endothelial Dysfunction in DiabetesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC15 571.1 Potential utility of single and concomitantadministration of pioglitazone and simvastatin in amelioratingendothelial dysfunction in diabetic insulin-resistant rats. N.N.Nassar and M.F. Schaalan. Fac. of Pharm., Cairo Univ. andFac. of Pharm., Misr Intl. Univ., Egypt.156

sundayC16 571.2 The role of endothelium-derived relaxing factorsin mesenteric endothelial function in streptozocin-induceddiabetic rats. R. Zhang, L. Anderson and R. Rahimian. Sch.of Pharm. and Hlth. Sci. and Sch. of Dent., Univ. of Pacific.C17 571.3 Inhibition of NADPH oxidase restoresvasoreparative function in diabetic CD34 + cells. Y.P.R. Jarajapu,S. Caballero, Q. Li and M. Grant. Univ. of Florida.C18 571.4 Endothelium-derived reactive oxygen speciesimpair myogenic tone in type-2 diabetic rat ophthalmic artery.Y.P.R. Jarajapu, I. Ito, D. Guberski and M. Grant. Univ. ofFlorida, Showa Univ., Japan and Biomed. Res. Models Inc.,Worcester, MA.C19 571.5 Toll-like receptor 4 deficiency attenuates insulinresistance and endothelial dysfunction associated with obesityand diabetes in mice. C-F. Liang, A. Xu and P.M. Vanhoutte.Univ. of Hong Kong.C20 571.6 TNF-derived TIP peptide ameliorates highglucose-induced arginase mediated endothelial dysfunctionvia inhibiting PKC-a activation. M.J. Romero, G. Yang, S.Chandra, S. Sridhar, R. Lucas and R.W. Caldwell. Med. Col.of Georgia.C21 571.7 Inhibition of lactate-producing glycolysisincreases antidiabetic drug-induced vasorelaxations and blockssildenafil’s attenuation of them. J.D. Peuler and L.E. Phelps.Midwestern Univ., IL.C22 571.8 Changes in angiotensin II type 2 receptorfunction in the aorta of diabetic rats over time. R. Sabra, A. Al-Hariri and R. Ghali-Ghoul. American Univ. of Beirut.C23 571.9 Effects of PETN and ISDN on vasculardysfunction and oxidative stress in an experimental model ofdiabetes. M. Knorr, M. Oelze, S. Schuhmacher, P. Wenzel, C.Hochmuth, S. Steven, T. Heeren, D. Stalleiken, T. Muenzeland A. Daiber. Univ. Hosp. Mainz and Actavis, DeutschlandGmbH & Co., Langenfeld, Germany.C24 571.10 C-peptide restores mitochondrial complex 1activity and lowers superoxide levels in high glucose-treatedmurine renal microvascular endothelial cells. H.L. Vejandla,E.R. Dabkowski, J.M. Hollander and R.W. Brock. WestVirginia Univ.572. Myocardial Dysfunction in DiabetesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC25 572.1 PKC b inhibitor ruboxistaurin prevents theincrease of 15-F2t-isoprostane in the myocardium and plasmain type 1 diabetic rats. Y. Liu, S. Lei, H-m. Liu, X. Mao, G.T.Wong, P.M. Vanhoutte, M.G. Irwin and Z. Xia. Univ. of HongKong.C26 572.2 Hypoxia-inducible factor 1a is critically involvedin metallothionein protection against diabetic cardiomyopathy.W. Feng, W. Xue and J. Zhao. Univ. of Louisville.C27 572.3 Aldehyde dehydrogenase activator attenuatesdiabetic cardiomyopathy: a role in improving the quality ofresident cardiac stem cells? S.S. Palaniyandi, M-H. Disatnik,L. Sun, J.J. Vishnumangalam, X. Xia, A. Pavlovic, V. Bhalla,E. Ashley and D. Mochly-Rosen. Stanford Univ.C28 572.4 Potentiation of aspirin-induced cardioprotectionby minocycline against myocardial ischemia reperfusion injuryin streptozotocin diabetic rat. L.K. Bhatt and V. Addepalli. Sch.of Pharm. and Technol. Mgmt., NMIMS Univ., India.pharmacologyC29 572.5 Ruboxistaurin attenuates hypertriglyceridemiain diabetic rats: comparison with the antioxidant N-acetylcysteine.Y. Liu, S. Lei, H-m. Liu, X. Mao, G.T. Wong, P.M. Vanhoutte,M.G. Irwin and Z. Xia. Univ. of Hong Kong.573. Cardioprotection, Cardiac Injury andRemodelingPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC30 573.1 Inhibition of vasoconstriction by amlodipine inhuman internal mammary arteries used as bypass grafts. G-W.He , X-Y. Bai, X-C. Liu, W-B. Jing, L. Fan and Q. Yang. TEDAIntl. Cardiovasc. Hosp. and Med. Col., Nankai Univ., People’sRepublic of China, Oregon Hlth. & Sci. Univ. and Chinese Univ.of Hong Kong.C31 573.2 SR Ca 2+ -handling proteins and PKC: a rolein low molecular weight FGF2-mediated cardioprotection. B.Oloizia, J. Bodmer and J.E. Schultz. Univ. of Cincinnati.C32 573.3 Endothelin-1 blockade with bosentanattenuates15-F2t-isoprostane adverse effects on postischemicrat hearts. Z. Xia, H-m. Liu, Z-y. Xia, Y. Liu, S. Lei, X. Maoand M.G. Irwin. Univ. of Hong Kong and Renmin Hosp., WuhanUniv., People’s Republic of China.C33 573.4 The anti-atherogenic potential of C-typenatriuretic peptide: disparate regulation of endothelial andvascular smooth muscle cell proliferation via natriuretic peptidereceptor-C. R.S. Khambata, C.M. Panayiotou, F. Xiao andA.J. Hobbs. University Col. London.C34 573.5 AT1 receptor-specific downregulation of Smad7plays a key role in atrial fibrillation-induced myocardial fibrosis.D.D. Duan, X. He, L. Peng, S. Wang, H. Ma, J. Lin and X.Gao. Univ. of Nevada, Reno, First Affiliated Hosp., Sun Yat-SenUniv., People’s Republic of China and SUNY Downstate Med.Ctr.C35 573.6 Molecular identification of the constitutivelyactivatedvolume-regulated Cl - channels in hypertrophiedventricular myocytes. D.D. Duan, G. Wang, L. Liu and L.L. Ye.Univ. of Nevada, Reno and Zhongshan Med. Col., Sun Yat-senUniv., People’s Republic of China.C36 573.7 Monoamine oxidase B gene deletion preventscardiac pump dysfunction in mice with pressure overload. N.Kaludercic, E. Takimoto, T. Nagayama, E. Lai, K. Chen, J.C.Shih, K. Pacak, D.A. Kass, F. Di Lisa and N. Paolocci. JohnsHopkins Med. Instns., Univ. of Padova, NICHD, NIH and Univ.of Southern California.C37 573.8 The chemical chaperone tauroursodeoxycholicacid alleviates cardiac contractile dysfunction in obesity: roleof endoplasmic reticulum-stress in cardiac functionality. A.F.Ceylan Isik, J. Ren and N. Sreejayan. Univ. of Wyoming.C38 573.9 Role of O-linked b-N-acetylglucosamine inisoflurane-induced cardiac protection. Y.M. Tsutsumi, K.Hirose, E. Katayama, R. Tsutsumi, M. Kinoshita, K. Tanakaand S. Oshita. Univ. of Tokushima, Japan.C39 573.10 Co-regulation of cardioprotective geneexpression by NF-kB, AP-1, and STAT3 in late phase ischemicpreconditioning. M. Tranter, M. McGuinness, W. Paulding, L.Haar, X. Ren and W.K. Jones. Univ. of Cincinnati and XavierUniv., OH.sun157

PharmacologyC40 573.11 Inducible cardiac-specific RhoA-expressionprotects against ischemia/reperfusion injury in mouse hearts.S.Y. Xiang, H. Ling, D.P. Del Re, N.H. Purcell, S. Miyamoto,S.J. Matkovich, G.W. Dorn and J.H. Brown. UCSD andWashington Univ. Sch. of Med.C41 573.12 microRNA regulation of Hsp70.3 proteinexpression in late ischemic preconditioning. R.N. Helsley, M.Tranter, W. Paulding, X. Ren, M. McGuinness and K. Jones.Miami Univ., Univ. of Cincinnati and Xavier Univ.C42 573.13 Isoflurane preconditioning modulates theexpression of eNOS and eNOS-related genes during myocardialischemia and reperfusion. I. Baotic, S. Sudhakaran, P.F. Prattand J. Kersten. Med. Col. of Wisconsin.C43 573.14 Myocardial TRPV activation associated withhigh fat diet and cardioprotection. L.L. Haar, J. Rubinstein, M.Tranter, M. Jiang and W.K. Jones. Univ. of Cincinnati Med.Ctr.574. ThrombosisPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC44 574.1 Drug rediscovery: glybenclamide exhibitsthromboxane receptor dependent antithrombotic activity. H.J.Ting and F. Khasawneh. Western Univ. of Hlth. Sci., CA.C45 574.2 Thrombin sponge: a potent nanoparticleapproach to inhibiting coagulation in acute thrombosis. J.W.Myerson, L. He, D.M. Tollefsen and S.A. Wickline. WashingtonUniv. in St. Louis.C46 574.3 Celecoxib administration interferes with theanti-platelet effect of low dose aspirin in canines. D.A. Lauver,R.A. Frieler, W.L. Smith and B.R. Lucchesi. Univ. of MichiganMed. Sch.C47 574.4 12-Lipoxygenase plays a significant role inregulation of human platelets activation. P.L. Apopa, J. Vesci,O. Boutaud, A. Jadhav, A. Simeonov, G. Rai, D.J. Maloney,T. Holman, V. Kenyon and M. Holinstat. Thomas JeffersonUniv., Vanderbilt Univ., NHGRI, NIH and Univ. of California,Santa Cruz.C48 574.5 A novel antagonist for the thromboxane A 2receptor. F.T. Khasawneh and H.J. Ting. Western Univ. of Hlth.Sci.575. Vascular Pharmacology: GeneralPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC49 575.1 Dysfunction of endothelial and smooth musclecells in small arteries of a mouse model of Marfan syndrome.H. Syyong, A.W.Y. Chung, C.H.H. Yang and C. van Breemen.Univ. of British Columbia and Child and Family Res. Inst.,Vancouver.C50 575.2 Thalidomide produces vascular relaxations.J.R. Docherty and S.W. Seto. Royal Col. of Surgeons inIreland.C51 575.3 Cardiac-specific overexpression of catalaseprolongs survival and attenuates paraquat-induced myocardialcontractile dysfunction. W. Ge, H. Ma, Y. Zhang, X. Han and J.Ren. Univ. of Wyoming.sundayC52 575.4 8-pCPT-conjugated cyclic AMP analogs exertthromboxane receptor antagonistic properties. M. Schmidt,C. Sand, M. Grandoch and P. Oude Weernink. Univ. ofGroningen, Netherlands and Univ. Clin. Essen, Germany.C53 575.5 Role of sex steroids in the regulation of the UAmyogenic tone during pregnancy at high altitude. K. Chang, D.Xiao, Q. Xue and L. Zhang. Loma Linda Univ. Sch. of Med.C54 575.6 l-Tryptophan methyl ester evokes endothelium-,serotonin-independent biphasic vasoconstrictor and vasodilatorresponses in rat mesenteric arterioles. A.B. Jadhav, L.R.Nadithe, J. Balsevich, J. Akhtar and V. Gopalakrishnan.Univ. of Saskatchewan and Royal Univ. Hosp., Saskatoon.C55 575.7 Characterization of the relaxant response toequilin in rat mesenteric arteries. F. Filgueira, N. Lobato, G.Ceravolo, A.P. Dantas, Z. Fortes, R.C. Webb, R.C. Tostes andM.H. Carvalho. Univ. of São Paulo and Med. Col. of Georgia.C56 575.8 Effects of PETN and GTN on activity of purifiedhuman mitochondrial aldehyde dehydrogenase. M. Knorr, A.Daiber, J. Kamuf, A. Pautz, M. Oelze, J. Art and H. Kleinert.Univ. Hosp. Mainz, Germany.C57 575.9 Vascular endothelial growth factor inhibitorsinduce hypertension, afferent arteriolar dysfunction, andglomerular injury. T. Nagasawa, S.M. Shaw, K.A. Walsh, J.L.Meyer, M.C. Shaw and J.D. Imig. Med. Col. of Wisconsin.576. Vascular Pharmacology: Ion ChannelsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC58 576.1 L-type Ca 2+ channels are silent duringdepolarization of venous smooth muscle. K. Thakali, S.V.Kharade, S.W. Rhee and N.J. Rusch. Univ. of Arkansas forMed. Sci.C59 576.2 Effect of b3 subunit deletion on L-type calciumchannels in mouse small mesenteric arteries. S.V. Kharadeand N.J. Rusch. Univ. of Arkansas for Med. Sci.C60 576.3 PSD 95 scaffolds associated with vascular K v1channels are post-transcriptionally downregulated in cerebralarteries during hypertension. B.K. Joseph, N.J. Rusch andS.W. Rhee. Univ. of Arkansas for Med. Sci.C61 576.4 Alteration in contractile mechanism of ratcavernosal smooth muscle induced by different class diuretics.M.A. Claudino, F.I. Takeshi, F.B.M. Priviero, E. Antunes, A.Lopes and G. De Nucci. Univ. of Campinas, Brazil and Univ.Fed. of Rio de Janeiro.577. CNS Mechanisms in CVP FunctionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC62 577.1 Preconditioning by sub-lethal ischemia/reperfusion or glibenclamide ameliorates lactate dehydrogenaseactivity to different extends in rat hippocampus and cerebralcortex (brain) subjected to ischemia/reperfusion injury. N.N.Nassar, D.M. Abdallah, R.M. Abd-El-Salam and A.A. Abdel-Rahman. Fac. of Pharm., Cairo Univ. and Brody Sch. of Med.at East Carolina Univ.158

sundayC63 577.2 Enhancement of the rostral ventrolateralmedulla ERK1/2/nNOS/NO signaling pathway is implicated inthe central cannabinoid receptor-evoked sympathoexcitation inconscious rats. B.M. Ibrahim and A.A. Abdel-Rahman. EastCarolina Univ.C64 577.3 Hemeoxygenase-carbon monoxide signalingin the rostral ventrolateral medulla is implicated in ethanolevokedsympathoexitation and pressor response in the SHR.N.N. Nassar, G. Li and A.A. Abdel-Rahman. Brody Sch. ofMed. at East Carolina Univ.C65 577.4 Enhanced hemeoxygenase-1 signaling in therostral ventrolateral medulla mediates a critical protective roleagainst genetically elevated blood pressure in SHR rats. N.N.Nassar, G. Li and A.A. Abdel-Rahman. Brody Sch. of Med. atEast Carolina Univ.578. Neuropharmacology: AminesPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC66 578.1 CREB regulation of the CART gene in the ratnucleus accumbens and GH3 cultured cells. G.A. Rogge, D.C.Jones, E. Nestler and M.J. Kuhar. Emory Univ. and MountSinai Sch. of Med.C67 578.2 CART peptide may be an endogenousantidepressant. M. Job, I. McNamera and M.J. Kuhar. EmoryUniv.C68 578.3 Differential cocaine-induced changes in striatalglutamate receptor phosphorylation in low and high cocaineresponding rats. D. Yamamoto and N.R. Zahniser. Univ. ofColorado Denver, Aurora.C69 578.4 Contingent methamphetamine administrationdecreases dopamine and vesicular monoamine-2 transporterfunction. L.M. McFadden, P.L. Vieira-Brock, K.A. Stout, S.M.Nielsen, D.G. Wilkins, G.R. Hanson and A.E. Fleckenstein.Univ. of Utah.C70 578.5 Trace amine-associated receptor 1 mediatesmethamphetamine effects on monoamine transporter function.G.M. Miller and Z. Xie. Harvard Univ./New England PrimateRes. Ctr.C71 578.6 Modeling antidepressant binding at thehuman serotonin transporter. C.P. Kuntz, N.R. Sealover, S.Mukhopadhyay and E.L. Barker. Purdue Univ.C72 578.7 Visualizing RNA interference mediatedknockdown of the 5-HT 1Areceptor. N.L. Dudek, J.E. Vantreaseand K.E. Scrogin. Loyola Univ. Chicago Sch. of Med.C73 578.8 Desipramine is a novel modulator ofnorepinephrine-induced signaling through the alpha2Aadrenergic receptor. C.M. Cottingham and Q. Wang. Univ. ofAlabama at Birmingham.pharmacology579. Cholinergic Receptors: Structure andFunctionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC74 579.1 Validating the acetylcholine binding protein’sconversion potential to a human nicotinic acetylcholinereceptor. Á. Nemecz and P. Taylor. Skaggs Sch. of Pharm. andPharmaceut. Sci., UCSD.C75 579.2 Ligand design for human nicotinic acetylcholinereceptors using in situ freeze-frame click chemistry. J. Yamauchi,A. Nemecz, K-Y. Ho, J.R. Fotsing, T. Weide, N. Grimster, B.Stump, T.T. Talley, V.V. Fokin, K.B. Sharpless and P. Taylor.Skaggs Sch. of Pharm. and Pharmaceut. Sci., UCSD and TheScripps Res. Inst.C76 579.3 Interaction of tricyclic antidepressants withthe human a4b2 nicotinic receptor. D.E. Blaty, H.R. Arias,A. Rosenberg, K.M. Targowska-Duda, D. Feuerbach, K.Jozwiak, R. Moaddel and I.W. Wainer. Arizona Col. of Osteo.Med., Midwestern Univ., NIA, NIH, Baltimore, Med. Univ. ofLublin, Poland and Novartis Insts. for Biomed. Res., Basel.C77 579.4 Crystallographic comparison of nicotinicligands in complex with the acetylcholine binding protein. T.T.Talley, J.F. Park, J. Wu, K-Y. Ho, B. Sankaran and P. Taylor.Lawrence Berkeley Natl. Lab. and Skaggs Sch. of Pharm. andPharmaceut. Sci., UCSD.C78 579.5 Dual allosteric modulators of neuronal nicotinicacetylcholineand GABA Areceptors. K.W. Gee, T. Johnstone,D.J. Hogenkamp, R. Yoshimura, E.R. Whittemore, Z. Gu andJ. Yakel. Univ. of California, Irvine and NIEHS, NIH, ResearchTriangle Park.C79 579.6 Effect of streptozotocin on neurogenic M 2andM 3muscarinic receptor-mediated contractions in mouse urinarybladder. K.J. Pak and F.J. Ehlert. Univ. of California, Irvine.C80 579.7 The actions of piperidine alkaloids at fetalmuscle-type and autonomic-type nicotinic acetylcholinereceptors. B.T. Green, S.T. Lee, K.E. Panter, K.D. Welch, D.Cook, J.A. Pfister and W.R. Kem. USDA, Logan, UT and Univ.of Florida.580. Behavioral Pharmacology: Alcoholand NicotinePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC81 580.1 Accuracy and reliability of consumer breathalcohol analyzers. W. Davis, J.C. Andrews, E. Herb, J.R. Lee,N.S. Latman and C.L. Bouma. West Texas A&M Univ.C82 580.2 Pilot safety evaluation of varenicline for thetreatment of methamphetamine dependence. R. Sevak, T.Zorick, K. Miotto, S. Shoptaw, A-N. Swanson, C. Clement,R. De La Garza II, T.F. Newton and E. London. UCLA andBaylor Col. of Med.C83 580.3 Effects of varenicline on the discriminativestimulus effects of nicotine in female cynomolgus monkeys.B.L. Blaylock, S.H. Nader and M.A. Nader. Wake Forest Univ.Sch. of Med.sun159

PharmacologyC84 580.4 Nicotine and varenicline share discriminativestimulus properties and act through mecamylamine-sensitivereceptors in rhesus monkeys. C.S. Cunningham and L.R.McMahon. Univ. of Texas Hlth. Sci. Ctr. at San Antonio.C85 580.5 Cytisine attenuates nicotine-induced ethanolconsumption in C57BL/6J mice. R. Sajja, M. Spinar and S.Rahman. South Dakota State Univ.C86 580.6 Adolescent nicotine exposure enhancesalcohol self-administration, and subsequently affects extinctionof conditioned fear response. A. Larraga, S. McQuown, J.D.Belluzzi and F.M. Leslie. Univ. of California, Irvine.C87 580.7 Nicotinic and muscarinic receptors in the ratdorsal hippocampus mediate the conditioned place preferenceinduced by ethanol. P. Rostami and M.R. Zarrindast. TarbiatMoallem Univ. and Tehran Univ., Iran.C88 580.8 The ability of repeated nicotine exposure to alterlocomotor activity and prefrontal cortex CREB phosphorylationin adolescent rats depends on sensation-seeking phenotype.R.M. Philpot, M.E. Engberg and L. Wecker. Univ. of SouthFlorida.C89 580.9 Effects of nicotine pretreatment on cocaineseekingbehavior. C.Y. Mojica, J.D. Belluzzi and F.M. Leslie.Univ. of California, Irvine.581. Opioids and CannabinoidsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC90 581.1 Exploration of novel radioiodine-labelingtechniques for opioid peptides. J.E. Pickett, S. Majumdar, M.Burgman and G.W. Pasternak. Mem. Sloan-Kettering CancerCtr.C91 581.2 Morphine-induced motor stimulation andataxia: differences among adolescent, late adolescent, andadult mice. W. Koek and C.P. France. Univ. of Texas Hlth. Sci.Ctr. at San Antonio.C92 581.3 The central antidepressant-like andantinociceptive effects of a delta opioid receptor agonist SNC80in rats. C-M. Chen, C-C. Cheng, P-Y. Su and M-C. Ko. Natl.Cheng Chi Univ., Taiwan and Univ. of Michigan.C93 581.4 Effects of intradermal administration ofendogenous opioid peptides, b-endorphin and dynorphin-A,on scratching behavior in mice. E. Hu, C.M. Cremeans, S.M.Husbands and M-C. Ko. Univ. of Michigan Med. Sch. and Univ.of Bath, U.K.C94 581.5 Interactions between the serotonin/norepinephrine uptake inhibitor clomipramine and mu opioidagonists in rhesus monkeys: role of mu agonist efficacy. M.L.Banks and S.S. Negus. Virginia Commonwealth Univ.C95 581.6 Effect of chronic in vivo exposure to opioidversus cannabinoid receptor agonists on CB1 and mu-opioidreceptor protein level in the guinea pig longitudinal musclemyentericplexus model. H.T. Maguma and D.A. Taylor. BrodySch. of Med. at East Carolina Univ.C96 581.7 Pro-depressant-like effects of CB1 receptorinverse agonists/antagonists in male Sprague-Dawley rats.E.M. Jutkiewicz, A. Makriyannis, K. Vemuri and J. Bergman.Univ. of Michigan, Northeastern Univ. and McLean Hosp.,Belmont, MA.sundayC97 581.8 Dopamine D2-like receptors mediate thediscriminative stimulus effects of delta-9-tetrahydrocannabinolin rhesus monkeys. J.L. Stewart and L.R. McMahon. Univ. ofTexas Hlth. Sci. Ctr. at San Antonio.C98 581.9 Elevation of endocannabinoids via inhibitionof their catabolic enzymes attenuates the precipitated opioidwithdrawal syndrome. D. Ramesh, J.Z. Long, K. Ahn, B.F.Cravatt and A.H. Lichtman. Virginia Commonwealth Univ.,The Scripps Res. Inst. and Pfizer Global R&D.582. Behavioral Pharmacology of MemoryCognition and LearningPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC99 582.1 The effects of positive allosteric modulation ofthe a7 nicotinic acetylcholine receptor in the five-choice serialreaction time task (5-csrtt). P. Horvath, R. Yoshimura, D.J.Hogenkamp and K.W. Gee. Univ. of California, Irvine.C100 582.2 Cognitive impairment and decreasedhippocampal neurogenesis after treatment withchemotherapeutic drugs. R.N. Pechnick, K.C. Reyes, M. Das,L.M. Lacayo, C. Farrokhi, S. Zonis and V. Chesnokova.Cedars-Sinai Med. Ctr.C101 582.3 Alpha-1Aa adrenergic receptor stimulationenhances learning and memory in mice. B.L. Goldenstein,M. Lyons, S. Wood, B. Nelson, R. Fagerlie, J. Haselton, D.Perez and V. Doze. Univ. of North Dakota Sch. of Med. & Hlth.Sci. and Cleveland Clin. Fndn.C102 582.4 Acute donepezil treatment does not attenuatethe deficit in learning observed in Ts65Dn mice, a model ofDown syndrome. G.R. Wenger. Univ. of Arkansas for Med. Sci.C103 582.5 Effects of memantine and donepezil on objectrecognition memory and hippocampal acetylcholine levelsin rats with cholinergic lesions. J. Ihalainen, T. Sarajarvi,S. Kemppainen, P. Keski-Rahkonen, M. Lehtonen, P.K.Banerjee and H. Tanila. A.I. Virtanen Inst. and Univ. of Kuopio,Finland and Forest Res. Inst., Jersey City.C104 582.6 Acute morphine increased both perseverativeand non-perseverative errors of rats in a modified attentionalset-shifting test. Y. Chen, A.M. Young, G.W. Schrimsher andM. Evola. Texas Tech Univ. Hlth. Sci. Ctr. and Texas Tech Univ.C105 582.7 Cognitive deficits associated with chroniccocaine self-administration in monkeys. R.W. Gould and M.A.Nader. Wake Forest Univ. Sch. of Med.C106 582.8 The interaction of chronic delta-9-tetrahydrocannabinol and estradiol during early adulthood haslong-term effects on learning in female rats. P.J. Winsauer andJ.L. Sutton. LSU Hlth. Sci. Ctr., New Orleans.C107 582.9 Phenotypical characterization of NPS precursorknockout mice. X. Liu and R.K. Reinscheid. Univ. of California,Irvine.160

sunday583. Pain Medication: Treatment andMechanicsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC108 583.1 Effect of diacerein alone and combinationwith aceclofenac in adjuvant-induced arthritis and in chronicinflammatory model in rats. B. Medhi, B.D.S. Prasad, S. Patyar,A. Prakash and U.N. Saikia. Postgrad. Inst. of Med. Educ. andRes., Chandigarh, India.C109 583.2 NSAIDs inhibit activity and reduce surfaceexpression of calpain proteases. K. Silver, L. LeLoup, L.C.Freeman, A. Wells and J.D. Lillich. Kansas State Univ. andUniv. of Pittsburgh Med. Ctr.C110 583.3 Activation of TRPA1 channels by fenamateNSAIDs. J.M. Herz, H. Hu, J. Tian, C. Wang, R. Xiao, J. Woodand M.X. Zhu. Algomedix, Mill Creek, WA and Ohio StateUniv.C111 583.4 The selective mu opioid antagonistb-funaltrexamine reduces Toll-like receptor-4 signaling. C.W.Stevens, S. Aravind and R.L. Davis. Oklahoma State Univ.Ctr. for Hlth. Sci.C112 583.5 The role of Gao in mu-opioid signaling andantinociception. J.A. Thomson, E.M. Jutkiewicz and J.R.Traynor. Univ. of Michigan.C113 583.6 Alterations in b-arrestin expression in guineapig ileum and colon following morphine tolerance. M. Kang, H.M.Payne, W.L. Dewey and H.I. Akbarali. Virginia CommonwealthUniv.C114 583.7 Competition between Gi/o-coupled receptorsprevents cAMP overshoot following chronic opioid treatment.E.S. Levitt and J.R. Traynor. Univ. of Michigan.C115 583.8 Effects of wheel running duration onosteoarthritis-induced shifts in hind limb weight bearing inrats. J. Jezierski, C. Dunbar, A. Luginbuhl, L. Benoit, M.Schuenke, E.J. Bilsky and G.W. Stevenson. Univ. of NewEngland.C116 583.9 Bisphosphonate targeting to specific skeletalsites in mice with whole body vibration. R.V. Papineni, S.Orton, T. Ji, H. Schmitthenner, W. McLaughlin, D. Vizard andJ. Pan. Carestream Hlth. Inc., New haven.584. GPCRs Dopamine ReceptorsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC117 584.1 Lipid rafts and membrane cholesterol areinvolved in regulating D2 dopamine receptor signaling. L.A.Hazelwood, R.J. Romanelli, R.B. Free, R.A. Roof, J.A.Javitch, K.A. Neve and D.R. Sibley. NINDS, NIH, Rockville,Oregon Hlth. & Sci. Univ. and Columbia Univ.C118 584.2 Ligand-specific roles for transmembrane 5serine residues in D1 dopamine receptor binding and activation.B.R. Chemel, L.A. Bonner, V.J. Watts and D.E. Nichols.Purdue Univ. and St. Anselm Col., NH.C119 584.3 Serine 5.43 of the D4 dopamine receptor playsa key role in its interactions with norepinephrine and Ro10-4548. J. Schetz, A. Goetz and D. Cummings. Univ. of NorthTexas Hlth. Sci. Ctr. and Friedrich Alexander Univ. Erlangen.pharmacologyC120 584.4 Functional selectivity of 9-OH-risperidone(paliperidone) versus risperidone at dopamine D2 receptors.M. Silva, T.A. Sanchez, K.A. Berg and W.P. Clarke. Univ ofTexas Hlth. Sci. Ctr. at San Antonio.C121 584.5 D3 dopamine receptor tolerance property:molecular mechanism and physiological relevance. S. Gil-Mast, S. Zalcman and E.V. Kuzhikandathil. UMDNJ-NewJersey Med. Sch.C122 584.6 Regulation of D2 dopamine receptors byG-protein coupled receptor kinase and b-arrestin. V.J.Thanawala, A. Kovoor, J. Celver and M. Sharma. Univ. ofRhode Island, Kovogen LLC, Mystic, CT.585. Regulation of Cell-Surface ReceptorsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC123 585.1 Constitutive PKC phosphorylation of the D1dopamine receptor inhibits receptor signaling. M.L. Rankinand D.R. Sibley. NINDS, NIH.C124 585.2 Desensitization of the dopamine D1-D2receptor heteromeric complex in primary striatal neuronsand bi-functional regulation by GRK2. V. Verma, A. Hasbi,B.F. O’Dowd and S.R. George. Univ. of Toronto and Ctr. forAddiction and Ment. Hlth., Toronto.C125 585.3 The interaction of G protein-coupled receptorkinase 4g with Ga sis required for inhibition of the b 2-AR.B.T. Andresen, M.K. Flynn, K. Sisk, M. Bastepe and E.K.Jackson. Univ. of Missouri-Columbia, Harry S Truman VA Med.Ctr., Harvard Med. Sch. and Univ. of Pittsburgh.C126 585.4 Attenuation of dynamin-dependentinternalization decreases antinociception during the expressionof morphine tolerance. T.A. Macey, L.W. Fyfe, M.M. Morganand S.L. Ingram. Washington State Univ. Vancouver.C127 585.5 Regulation of kappa opioid receptorresponsiveness on peripheral sensory neurons. T.A. Sanchez,M.P. Rowan, M. Silva, W.P. Clarke and K.A. Berg. Univ. ofTexas Hlth. Sci. Ctr. at San Antonio.C128 585.6 Omega-3 fatty acid mediated phosphorylationof the short and long human GPR120 receptor isoforms. R.L.Burns and N.H. Moniri. Col. of Pharm. and Hlth. Sci., MercerUniv.C129 585.7 A functional genomics approach identifiesGPCR endocytosis-regulating kinases. P. Hein, S. Herzig andM. von Zastrow. Univ. of Cologne and UCSF.C130 585.8 Hyperglycemia upregulates AT2 receptors viaIRF-1 in proximal tubule epithelial cells. Q. Ali and T. Hussain.Univ. of Houston.C131 585.9 A novel role for Ser25 in regulating class Ascavenger receptor trafficking. D.M. Nikolic, J. Cholewa andS.R. Post. Univ. of Arkansas for Med. Sci.C132 585.10 The diacidic ExD motif controls angiotensinII type 2 receptor export from the endoplasmic reticulum. X.Zhang and G. Wu. LSU Hlth. Sci. Ctr., New Orleans.C133 585.11 RACK1 regulates PP2A-mediated dephosphorylationof threonine 38 of the human nuclearxenobiotic receptor CAR. S. Mutoh, M. Osabe, R. Moore, K.Vinal, T. Sueyoshi and M. Negishi. NIEHS, NIH, ResearchTriangle Park.161sun

Pharmacology586. GPCRs: Arrestin Regulation andSignalingPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC134 586.1 Inhibition of LIMK activity by b-arrestins: amechanism for cofilin activation. A. Lin and K. DeFea. Univ. ofCalifornia, Riverside.C135 586.2 Functional characterization of b-arrestin 1/ERK scaffolding complex downstream of PAR2. J. Min and K.DeFea. Univ. of California, Riverside.C136 586.3 AT1 AR-b-arrestin signaling confers PPARgagonist-mediated myocyte contractility. D.G. Tilley, A. Nguyenand H.A. Rockman. Sch. of Pharm., Thomas Jefferson Univ.and Duke Univ. Med. Ctr.C137 586.4 Synergistic a1-adrenergic receptor mediatedincreases in IL-1b from lipopolysaccharide-challenged humanmonocytes is b-arrestin 1-dependent and NF-kB-independent.L.A. Grisanti and J.E. Porter. Univ. of North Dakota.C138 586.5 Identification of the nuclear localizationsequence in beta arrestin1: functional inplications in NF-kBactivation. C.Z. Hoeppner, N. Cheng and R.D. Ye. Univ. ofIllinois at Chicago.C139 586.6 Differences in beta arrestin dependent signalingby PAR2 and NK1R are determined by the C-terminal tails. K.Pal and K. DeFea. Univ. of California, Riverside.587. G-Protein RegulatorsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC140 587.1 Rgs16 is an early marker for islet formationand beta cell expansion in diabetics. O. Ocal, A. Villasenor,Z. Wang, L. Rivera, I. Wernstedt Asterholm, A. Artyukhin, P.Scherer, R. Brekken, O. Cleaver and T. Wilkie. Univ. of TexasSouthwestern Med. Ctr.C141 587.2 Identification of novel isoforms of regulatorof G-protein signaling 6. J. Yang, S-R. Ibeawuchi, J. Huang,A. Stewart, C-K.J. Chen and R.A. Fisher. Univ. of Iowa andVirginia Commonwealth Univ.C142 587.3 RGS7 protein suppression of Gao proteinmediateda2A-adrenergic receptor inhibition of mousehippocampal CA3 epileptiform activity. B.W. Nelson, B.Goldenstein, K. Xu, E. Luger, J. Wald, L. O’Shea, D.Weinshenker, B. Sjogren, R. Charbeneau, X. Huang, R.Neubig and V. Doze. Univ. of North Dakota, Emory Univ. andUniv. of Michigan.sundayC143 587.4 Regulation of the RGS14/Gia1-GDP signalingcomplex by phosphorylation. D.P. Cowan, F. Shu and J.R.Hepler. Emory Univ.C144 587.5 AGS3 blocks D2L dopamine receptor-mediatedheterologous sensitization of adenylyl cyclase 2. J.M. Conleyand V.J. Watts. Purdue Univ.C145 587.6 Movement of activator of G-protein signaling 3within the aggresome pathway. A. Vural, S.S. Oner, N. An, J.B.Blumer and S.M. Lanier. Med. Univ. of South Carolina.C146 587.7 Coupling of a G-protein coupled receptor to theAGS3-Gai signaling complex. S.S. Oner, N. An, A. Vural, B.Breton, M. Bouvier, J.B. Blumer and S.M. Lanier. Med. Univ.of South Carolina and Univ. of Montreal.C147 587.8 Receptor-regulated interaction of activator ofG-protein signaling 4 and Gai. S.S. Oner, E. Maher, B. Breton,M. Bouvier and J.B. Blumer. Med. Univ. of South Carolina andUniv. of Montreal.C148 587.9 Ric-8A binds to and regulates the activationstate of the RGS14:Gai1-GDP signaling complex. C.P. Vellano,F. Shu, S. Ramineni, C. Yates, G.G. Tall and J.R. Hepler.Emory Univ. Sch. of Med. and Univ. of Rochester Med. Ctr.588. Pharmacology and Women’s HealthPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:30 p m-2:45 p mC149 588.1 Modulation of response to stress by estradiolbenzoate and selective estrogen receptor agonists. E.L.Sabban, H.A. Harris and L.I. Serova. New York Med. Col. andWyeth Res., Collegeville, PA.C150 588.2 Characterization of estradiol-mediated, rapidenhancement of bradykinin signaling in sensory neurons. M.P.Rowan, K.A. Berg, K.M. Hargreaves, J.L. Roberts and W.P.Clarke. Univ. of Texas Hlth. Sci. Ctr. at San Antonio.C151 588.3 Gender differences in cardiac responses tocatecholamine stress in caloric restricted mice. L. Yan, S. Gao,L. Lai, H. Ge, C. Hong, D.E. Vatner and S.F. Vatner. UMDNJ-New Jersey Med. Sch.C152 588.4 Estrogen-induced resistance artery relaxationis nNOS- and age-dependent in postpartum rats. C. Royal andR. White. Med. Col. of Georgia.C153 588.5 Apolipoprotein mimetic peptide (L-4F)regulation of adiposity via increases in estradiol/testosteroneratio in obese female mice. A.P.H. Burgess, M. Li, D.H. Kim,L. Vanella, L.M. Palladino, K. Angevine, E. Mensah-Osmanand N.G. Abraham. Univ. of Toledo and New York Med. Col.C154 588.6 Pumpkin seed oil supplementation improvesHDL and LDL cholesterol in postmenopausal women: a randomdouble-blind pilot study. C.D. Hyde, M. Gossell-Williams, T.Hunter, D. Simms-Stewart, D. McGrowder, H. Fletcher andE. Choo-Kang. Univ. Hosp. and Univ. of West Indies, Jamaica.162

sundayPhysiologyphysiology589. Atherosclerosis/Thrombosis/PlateletsPoster(Sponsored by: The Microcirculatory Society)Su n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD1 589.1 Acetylsalicylic acid enhances purinergicreceptor-mediated outward currents in rat megakaryocytes. J.P.Young, J. Beckerman, S. Vicini and A. Myers. GeorgetownUniv.D2 589.2 Ginkgo biloba extract ameliorates the formationof foam cells by regulating the expression of SR-A and ABCA1in macrophage: role of heme oxygenase-1. K-H. Su, J-Y. Tsai,Y.R. Kou, A-N. Chiang and T-S. Lee. Natl. Yang-Ming Univ.,Taiwan.D3 589.3 T-lymphocytes contribute to angiotensinII-mediated thrombosis in cremaster muscle arterioles.E.Y. Senchenkova and D.N. Granger. LSU Hlth. Sci. Ctr.,Shreveport.D4 589.4 Involvement of NF-kB/ERK and Sp1/p38MAPK pathways in HNE-induced 5-lipoxygenase expression inmurine macrophages. C.D. Kim, S.J. Lee, C.E. Kim, K.W. Seo,H.M. Park, J.W. Yun and J.U. Bae. Sch. of Med., Pusan Natl.Univ., Republic of Korea.D5 589.5 Platelet function and relationship to coronaryartery disease risk in early menopausal women. V.M. Miller,M. Jayachandran, R.D. Litwiller, B.D. Lahr, K.R. Bailey, J.A.Heit and W.G. Owen. Mayo Clin.D6 589.6 MLCK210 deficiency amelioratesatherosclerosis in apoE knockout mice. C. Sun, M.H. Wu andS.Y. Yuan. Univ. of California, Davis and Sch. of Med.D7 589.7 BPP-10c isolated from Bothrops jararacavenom has antithrombotic effect in rats. D.A. Ianzer, C.H.Xavier, R.A. Fraga-Silva, F. Faria, A.C.M. Camargo, R.A.S.Santos and M.M. Teixeira. Butantan Inst., São Paulo and Fed.Univ. of Minas Gerais, Brazil.D8 589.8 Interleukin 17 promotes atherosclerosis andprotects against aneurysmal rupture. M.S. Madhur, S.A. Funt,Y. Blinder and D.G. Harrison. Emory Univ.D9 589.9 Cellular mechanism to infection-inducedthrombotic risk. M. Jayachandran, B.J. Sticha and V.M. Miller.Mayo Clin.D10 589.10 Selective serotonin reuptake inhibitors influenceagonist-induced platelet aggregation: preliminary results fromco-morbidity of depression and cardiovascular disease study.E. Litinas, J. Fareed, O. Iqbal, E. Tobin, J. Piletz, E. Mereshand A. Halaris. Loyola Univ. Med. Ctr.D11 589.11 Lipopolysaccharide and induction of bloodborne cell-derived microvesicles. J. Xiong, V.M. Miller and M.Jayachandran. Mayo Clin.D12 589.12 Assembly of the prothrombinase complexon fibroblast surface, promoted by TSP1, results in cytokinerelease and CTGF upregulation. M.C. Rico, J.J. Rough, F.E.Del Carpio-Cano, F. Safadi, S.P. Kunapuli and R.A. DeLaCadena. Temple Univ. Sch. of Med.D13 589.13 Platelet P-selectin mediates cytomegalovirusinducedmicrovascular dysfunction. K. Stokes, I.L. Leskovand E.V. Senchenkov. LSU Hlth. Sci. Ctr., Shreveport.D14 589.14 Gender-specific cardiovascular advantagesin apolipoprotein E knockout mice and effects of captopriltreatment on late-stage atherosclerotic lesion progression. J.D.Procknow, R. Sprague and A.H. Stephenson. Saint LouisUniv.D15 589.15 Arsenic-induced endothelial activation:contribution of endoplasmic reticulum stress. S. Srivastava,S.D. Sithu, E. Vladykoskaya, P. Haberzettl and S.E. D’Souza.Univ. of Louisville.D16 589.16 Polymicrobial sepsis and endotoxemia promotemicrovascular thrombosis via distinct mechanisms. K. Patel,S.H. Soubra, F.W. Lam and R.E. Rumbaut. Baylor Col. ofMed. and Michael E. DeBakey VA Med. Ctr.D17 589.17 ICAM-1 is key molecule in carbamylatedLDL-induced monocyte adhesion. E. Apostolov, D. Ray, A.Savenka, S. Shah and A. Basnakian. Univ. of Arkansas forMed. Sci. and Central Arkansas Veterans Healthcare Syst.D18 589.18 Antioxidant and anti-inflammatory properties ofApoA-I Milano. M. Purushothaman, P. Puru, G. Cimmino andJ.J. Badiom. Mount Sinai Sch. of Med. and Cornell Univ.590. Inflammation/Leukocyte-EndotheliumInteractionsPoster(Sponsored by: The Microcirculatory Society)Su n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD19 590.1 Angiotensin II induced cerebral microvascularinflammation and increased blood-brain barrier permeabilityvia oxidative stress. M. Zhang, Y. Mao, R.F. Tuma and T.Chabrashvili. Temple Univ. and Temple Univ. Hosp.D20 590.2 Stressed microvilli and long tethers in rolling,tight adhesion zones and aft trunks in arresting neutrophilsrevealed using total internal reflection fluorescence microscopy.P. Sundd, E. Gutierrez, M. Pospieszalska, A. Groisman andK. Ley. La Jolla Inst. for Allergy & Immunol. and UCSD.D21 590.3 Activation of calcium-independentphospholipase A 2b increases platelet activating factor andPGI 2production in cardiac endothelial cells. J.S. Sharma andJ. McHowat. Saint Louis Univ.D22 590.4 Gut wall compromise in the presence ofpancreatic enzymes causes circulatory shock. E.B. Kistlerand G.W. Schmid-Schonbein. UCSD.D23 590.5 Monocyte adhesion and endothelialhyperpermeability are associated with failure of arteriovenousfistula maturation for hemodialysis access. E.S. Lee, Q. Shen,M. Guo, R.L. Pitts, M.H. Wu and S.Y. Yuan. Univ. of California,Davis, Sacramento.D24 590.6 Cystathionine b-synthase and cystathionineg-lyase double gene transfer ameliorated homocysteinemediatedmesangial inflammation through hydrogen sulfidegeneration. U. Sen, N. Qipshidze, O.A. Abe, N. Metreveli andS.C. Tyagi. Univ. of Louisville.D25 590.7 The vasodilatory peptide maxadilan increasesvascular permeability due to activation of leukocytes inpostcapillary venules. E. Svensjo, V. Cruz, E.M. Saraiva, M.T.Bozza, E.A. Lerner and J. Scharfstein. Fed Univ. of Rio deJaneiro and Biol. Res. Ctr., Boston.163sun

PhysiologyD26 590.8 PI3K/Akt signaling pathway controls PGE 2-induced ICAM-1 expression through activation of NF-kB. T.Y.Park, Y-S. Jung, E.J. Baik, C-H. Moon and S.H. Lee. AjouUniv. Sch. of Med., Republic of Korea.D27 590.9 Interaction of (alpha4 beta1) integrin/VCAM-1induces myosin light chain phosphorylation in monocytes andendothelial cells. M. Haidari, W. Zhang, Z. Chen, L. Gangeheiand R. Dixon. Univ. of Texas Hlth. Sci. Ctr. and Texas HeartInst., Houston.D28 590.10 Pentoxifylline reduces endothelial activationinduced by cytokine and HIV-derived peptides: implicationsfor HIV-associated cardiovascular disease. C. Kim, S. Gupta,G. Rajashekhar, B. Taylor, N. Gollahalli, A. Renwick and M.Clauss. Indiana Univ. Sch. of Med.D29 590.11 PAR4 deficiency inhibits microvascularinflammation after cerebral ischemia/reperfusion injury. Y. Mao,M. Zhang, S.P. Kunapuli and R. Tuma. Temple Univ.D30 590.12 Inhibition of protein kinase C beta II attenuateslocal hyperglycemia-induced leukocyte-endothelial interactions.Q. Chen, E. Iames, D. Torino, K-A. Perkins, B. Rueter, C.Prince and L.H. Young. Philadelphia Col. of Osteo. Med.D31 590.13 How blood brain barrier is breached in a mousemodel of INCL. A. Saha, J. Munasinghe, Z. Zhang, A. Hefferand A.B. Mukherjee. NICHD and NINDS, NIH.D32 590.14 Turning on inflammatory response tohomocysteine through activation of infammasomes inpodocytes. C. Zhang, M. Xia, Z-C. Wang, J-J. Hu, K.M. Boini,N. Li and P-L. Li. Med. Col. of Virginia, VCU.D33 590.15 Response of the murine urinary bladdermicrocirculation to lipopolysaccharide from Escherichia coliand Pseudomonas aeruginosa. P. Kowalewska, L. Burrowsand A.E. Fox-Robichaud. McMaster Univ., Canada.D34 590.16 Leukocyte adhesion and its contribution on thelocal oxidative and nitrosative stresses in microcirculation. S.Kar and M. Kavdia. Univ. of Arkansas.D35 590.17 TNFa compromises the inner earmicrocirculation in a sphingosine kinase 1/sphingosine-1-phosphate dependent manner: a novel mechanism for suddenhearing loss. E.Q. Scherer, J. Yang, K. Ivanov, C.D. Diehl, K.Reimann, P. Wangemann, U. Pohl, M. Canis, S. Strieth, J.Voigtlaender-Bolz, D. Lidington and S-S. Bolz. Tech Univ.Munich, Univ. of Toronto, Kansas State Univ. and LudwigMaximilians Univ. Munich.D36 590.18 Orthopedic trauma-induced pulmonarydysfunction in obese Zucker rats. L. Xiang. Univ. of MississippiMed. Ctr.D37 590.19 Effects of a 4-hour exposure to conventionalperitoneal dialysis fluids on the murine hepatic microcirculation.A. Patrick and A.E. Fox-Robichaud. McMaster Univ., Canada.591. Ischemia-Reperfusion/Free RadicalBiologyPoster(Sponsored by: The Microcirculatory Society)Su n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD38 591.1 Exposure to ambient ultrafine particulatematter exacerbates cardiac ischemia/reperfusion injury in acyclosporin-sensitive manner. R.C. Sloan, C.R. Frasier, B.L.Cathey, W.E. Cascio, R.M. Lust, R.B. Devlin, D.A. Brown andC.J. Wingard. East Carolina Univ. and EPA, Chapel Hill.sundayD39 591.2 Classical transient receptor potential channel6 is essential for ischemia-reperfusion injury of the lung. A.Dietrich, A. Sydykov, H. Kalwa, U. Storch, B. Fuchs, H.A.Ghofrani, T.W. Gudermann and N. Weissmann. PhilippsUniv. Marburg, Univ. of Giessen and Ludwig Maximilians Univ.Munich.D40 591.3 Effect of skeletal muscle ischemia-reperfusionpost-conditioning on antioxidant status in rats. M.A. Dubick, V.J.Mase, Jr., J.L. Barr, D.L. Grubbs, J.L. Roe and T.J. Walters.U.S. Army Inst. of Surg. Res., San Antonio.D41 591.4 Compartmentalized nitric oxide signalingat the myoendothelial junction can regulate gap junctioncommunication. A.C. Straub, S.R. Johnstone, A.K. Best, L.Palmer and B.E. Isakson. Univ. of Virginia.D42 591.5 Pyruvate-fortified fluid resuscitation suppressesinflammation and arrhythmogenesis during hemorrhagic shockand hindlimb ischemia. H. Gurji, B. Hoxha , D. Flaherty , J.Sun , D. Schulz , J. Blaylock , A. Olivencia-Yurvati and R.Mallet. Univ. of North Texas Hlth. Sci. Ctr.D43 591.6 Reduction of myocardial reperfusion injury bymechanical tissue resuscitation using a bio-absorbable patch.J.E. Jordan, J.J. Mays, J.E. Shelton, E.A. Thompson, A.K.Bryant, M.J. Morykwas and L.C. Argenta. Wake Forest Univ.Hlth. Sci.D44 591.7 Enhancing complement control on endothelialbarrier reduces renal dysfunction following ischemia/reperfusion injury. S.B. Pushpakumar, G. Perez-Abadia, N.Todnem, C. Soni, T. Fensterer, P.K. Patibandla, J. Barkerand C. Maldonado. Univ. of Louisville.D45 591.8 Disruption of the intestinal mucin layer andentry of pancreatic digestive enzymes in early stages of shock.M. Chang and G.W. Schmid-Schönbein. UCSD.D46 591.9 Concentration-dependent effects oftestosterone on glial cells undergoing oxygen/glucosedeprivation/reperfusion. J. Zhou, N. Chen, J. Shen, W. Jin, I.C.Bruce and Q. Xia. Honors Col. of Chu Kochen, Zhejiang Univ.and Zhejiang Univ. Sch. of Med., People’s Republic of China.D47 591.10 Acute hyperglycemia augments neurovascularinjury in diabetes. A. Ergul, M.M. Elgebaly, S. Ogbi, M.Johnson, E. Mezzetti and S.C. Fagan. Med. Col. of Georgiaand Univ. of Georgia Col. of Pharm.D48 591.11 Mitochondrial depolarization is not responsiblefor cardioprotection during ischemic preconditioning. D. Lee, R.Quarrie, B. Cramer, G. Steinbaugh, D.R. Pfeiffer, J.L. Zweierand J.A. Crestanello. Ohio State Univ. Med. Ctr.D49 591.12 The roles of protein kinase C epsilon andtetrahydrobiopterin /dihydrobiopterin related to endothelial nitricoxide synthase coupling/uncoupling in ischemia/reperfusion.K-A. Perkins, C. Zambrano, S. Pershad, Q. Chen, S. McGraw,J. Adams and L. Young. Philadelphia Col. of Osteo. Med.D50 591.13 Protection of NADHh-linked Fe-S clusters incardiac mitochondria by ranolazine. A.K. Gadicherla, W.E.Antholine, J.S. Heisner, A.K.S. Camara, M. Aldakkak, M.Yang, A.D. Boelens and D.F. Stowe. Med. Col. of Wisconsin.D51 591.14 Interstitial nitric oxide concentrations areelevated in rat gastrocnemius muscle following recovery fromfemoral occlusion. S. Fabris, A.A. Smith, B. Parlett and D.A.MacLean. Northern Ontario Sch. of Med. and Laurentian Univ.,Canada.D52 591.15 Characterization of a novel liposome basedtherapy to reduce complement deposition on cell membranes.G. Perez-Abadia, L. Goga, S.B. Pushpakumar, C.V. Soni, P.Olson, G. Anderson, J. Barker and C.J. Maldonado. Univ. ofLouisville and Potentia Pharmaceut., Louisville.164

sundayD53 591.16 Effect of Cuscuta chinensis on renal function inischemia/reperfusion-induced acute renal failure rats. S. Shin,A.S. Lee, E.J. Kim, D.G. Kang and H.S. Lee. ProfessionalGrad. Sch. of Oriental Med., Wonkwang Univ., Republic ofKorea.D54 591.17 Low dose nitrite enhances perfusion after fluidresuscitation from hemorrhagic shock. P. Cabrales. UCSD.D55 591.18 Substrate availability for both endothelial nitricoxide synthase and glucose-6-phosphate dehydrogenaseresult in enzyme dysfunction as a result of ischemia/reperfusioninjury: the role of NADPH in endothelial dysfunction. L.A.Reyes, C. Dumitrescu, R. Biondi, L. Druhan and J.L. Zweier.Ohio State Univ.592. Microvascular Pathophysiology/TumorMicrocirculationPoster(Sponsored by: The Microcirculatory Society)Su n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD56 592.1 Nuclear factor-kappa B expression and matrixmetalloproteinase activity in hypertension. K-I. Wu and G.Schmid-Schönbein. UCSD.D57 592.2 Tumor-derived TIMP-2 mediates endothelialbarrier dysfunction and breast cancer cell transmigration byactivating endothelial MMP-2. Q. Shen, E.S. Lee, R.L. Pitts,M.H. Wu and S.Y. Yuan. Univ. of California, Davis Sch. of Med.D58 592.3 Mechanisms of impaired acetylcholinemediatedvasodilation in overweight rats. M. Lekic, B.R. Walkerand K.L. Sweazea. Col. of Nursing and Hlth. Innovation,Arizona State Univ. and Univ. of New Mexico.D59 592.4 Retinal arteriolar endothelial dysfunction inearly stage of diabetes in porcine model. T.W. Hein, L.B. Potts,Y. Ren and L. Kuo. Texas A&M Hlth. Sci. Ctr., Temple.D60 592.5 Increased protease activity and receptorcleavage in a rat model of diet-induced obesity. R. Mazor andG. Schmid-Schönbein. UCSD.D61 592.6 Breast cancer microparticles promoteformation of a microenvironment favorable for lung metastasis.N.N. Bauer, J. Rai, H. Chen, L. Harris, L. Shevde and J. King.Univ. of South Alabama and Charleston Area Med. Ctr., WV.D62 592.7 Insulin supplementation elevates systolic bloodpressure and arteriolar tone in mice with type 2 diabetes. A.Feher, Y-M. Yang, D. Sun, G. Kaley and Z. Bagi. New YorkMed. Col.D63 592.8 Enhanced calcium sensitivity of endothelialcalcium-activated large conductance potassium channels. M.A.Riddle and B.R. Walker. Univ. of New Mexico.D64 592.9 Longitudinal investigation of permeability anddistribution of macromolecules in mouse tumor developmentand malignant transformation using PET. C.B. Rygh, J.W. Seo,S.P. Qin, L.M. Mahakian, H. Zhang, D.L. Kukis, J.Q. Chan, J.Cheng-Liao, R.K. Reed and K.W. Ferrara. Univ. of California,Davis and Univ. of Bergen, Norway.D65 592.10 Simultaneous measurement of RBC velocity,flux, hematocrit and shear rate in vascular networks in vivo.W.S. Kamoun, S-S. Chae, D.A. Lacorre, J.A. Tyrrell, M. Mitre,M.A. Gillissen, D. Fukumura and R.K. Jain. MassachusettsGen. Hosp., Harvard Med. Sch.593. Microvascular Pharmacology/TherapeuticsPoster(Sponsored by: The Microcirculatory Society)physiologySu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD66 593.1 Resveratrol protects the renal microcirculationduring sepsis. J.H. Holthoff and P.R. Mayeux. Univ. ofArkansas for Med. Sci.D67 593.2 S1P 1receptor activation is insufficient to mimicS1P-mediated effects on aqueous humor outflow physiology.G. Sumida and W.D. Stamer. Univ. of Arizona.D68 593.3 Intravenous infusion of keratose-based fluidinduces arteriolar vasodilation in cremaster muscle of rats. F.A.Nunez, S. Trach, M. Callahan, M. Van Dyke and T. Smith.Wake Forest Univ. Baptist Med. Ctr., Heidelberg Univ. andWake Forest Inst. of Regen. Med.D69 593.4 Glycogen synthase kinase 3b inhibitor protectsagainst vascular hyperpermeability following hemorrhagicshock. E.W. Childs, F.A. Hunter, B. Tharakan, D.A. Sawantand W.R. Smythe. Texas A&M Hlth. Sci. Ctr. Col. of Med. andScott and White Hosp., Temple.D70 593.5 Impaired arteriolar dilation in a mouse modelof familial hypercholesterolemia: impact of chronic exerciseand anti-cholesterol therapy. P.A. Stapleton, A.G. Goodwill,M.R. Morrisette, M.E. James and J.C. Frisbee. West VirginiaUniv. Hlth. Sci. Ctr.D71 593.6 Erythrocytes (RBCs) of humans with type 2diabetes (DM2) release ATP in response to activation of theprostacyclin receptor (IPR) but not in response to low PO 2.S. Knebel, M. Ellsworth, E. Bowles, R. Sprague and A.Stephenson. Saint Louis Univ.D72 593.7 The purinergic agonists ATP and UTP actpredominantly via P2Y receptors in human vascular endothelialcells. A.P. Braun, A. Raqeeb and J. Sheng. Univ. of Calgary.D73 593.8 Computational models of personalizedmedicine: leading indicators for angiogenesis therapies. F. MacGabhann and A.S. Popel. Johns Hopkins Univ. and JohnsHopkins Univ. Sch. of Med.594. Blood Pressure Regulation IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD74 594.1 Effects of high salt diet on age-relatedhypertension and central AngII-induced cardiovascularresponses. B. Basgut, B. Erdos, M. Whidden, N. Kirichenko,M. Woods and N. Tumer. Univ. of Florida, Gazi Univ., Turkeyand DVA Med. Ctr., Gainesville, FL.D75 594.2 Elderly women demonstrate an attenuatedvasoconstrictive response during a cold pressor stimulus.S.S. Jarvis, T.B. VanGundy, M. Galbreath, S. Shibata, R.L.Meier, W. Vongpatanasin, B. Levine and Q. Fu. Texas Hlth.Presbyterian Hosp. Dallas and Univ. of Texas SouthwesternMed. Ctr.sun165

PhysiologyD76 594.3 Age-related changes in stress-inducedcardiovascular and lumbar sympathetic nerve activityresponses. B. Erdos, B. Basgut, M. Whidden, N. Kirichenkoand N. Tumer. Univ. of Florida and VA Med. Ctr.D77 594.4 Sympathectomy does not inhibitdexamethasone-induced hypertension. A.E. Soto-Pina, S.Kadapakkam, C. Mehring, C. Hinojosa-Laborde and R.Strong. Univ. of Texas Hlth. Sci. Ctr. at San Antonio and SouthTexas Veterans Hlth. Care Syst.D78 594.5 Central TNF-alpha enhances pressorhemodynamic response to acute stressor. T. Zera, M. Ufnaland E. Szczepañska-Sadowska. Med. Univ. of Warsaw.D79 594.6 Peripheral vascular responses to an orthostaticchallenge and plasma volume in Parkinson’s disease patientswith orthostatic hypotension. M.T.E. Hopman, D.H.J. Thijssen,R.A.J. Esselink, M. van Aalst, J.P.H. Seeger, B.R. Bloemand J.T. Groothuis. Radboud Univ. Nijmegen Med. Ctr.,Netherlands.D80 594.7 Relationship between total peripheralresistance and measures of central artery wave reflection.J.R.A. Shepherd, E.C. Hart, T.B. Curry, N. Charkoudian, M.J.Joyner and D.P. Casey. Mayo Clin.D81 594.8 Vitamin C reduces AT 1R and AT 2R activationin the rostral ventrolateral medulla of hypertensive sucrosefedrats. T.G.C. Oliveira, E.B. Oliveira-Sales, D.E. Casarini,C.T. Bergamaschi, J.C. Heimann, R.R. Campos and M.S.Dolnikoff. Fed. Univ. of São Paulo, Brazil and Univ. of SãoPaulo.D82 594.9 Sex differences in the sympathetic balanceof blood pressure: the role of the a-adrenergic receptors.E.C. Hart, N. Charkoudian, B.G. Wallin, S.K. Roberts, C.P.Johnson and M.J. Joyner. Mayo Clin. and Sahlgren Acad. atGothenburg Univ., Sweden.D83 594.10 The effects of menstrual cycle on cardiovascularresponse to mental stress and arterial stiffness. R. Sone, N.Tan and F. Yamazaki. Yamaguchi Univ. and Sch. of Hlth. Sci.,Univ. of Occup. and Envrn. Hlth., Japan.595. Cardiac Electrophysiology IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD84 595.1 The effect of Na + -Ca 2+ exchange on therecovery from Ca 2+ dependent inactivation of L-type Ca 2+channel in cardiomyocytes in pulmonary vein. J-H. Kwon, W-T.Kim, H-A. Kim and C-H. Leem. Univ. of Ulsan Col. of Med.,Republic of Korea.D85 595.2 Alternans of repolarization and depolarizationin ventricular myocytes. S. Chourasia, A. Agarwal, L. Jingand A. Patwardhan. Univ. of Kentucky.D86 595.3 Identification of the impact of contention onheart rate variability. H. Mongue-Din, A. Salmon, M.Y. Fiszmanand Y. Fromes. CNRS, Inst. of Myology, Paris and Gp. Hosp.Paris Saint Joseph.D87 595.4 A single exposure to acrolein causesarrhythmogenesis, cardiac electrical dysfunction and decreasedheart rate variability in hypertensive rats. M.S. Hazari, J. Griggs,N. Haykal-Coates, D. Winsett, A. Farraj and D. Costa. U.S.EPA, Research Triangle Park and Univ. of North Carolina atChapel Hill.sundayD88 595.5 New applications of automated electrophysiology:heat activation of TRPV1 and action potentials ofcardiomyocytes. R. Haedo, A. Haythornthwaite, S. Stoelzle,C. Haarmann, C. Farre, D. Guinot, M. Kreir, J. Steindl, M.Beckler, M. George, A. Brueggemann and N. Fertig. NanionTechnol. Inc., New Brunswick, NJ and Munich.D89 595.6 The aging rabbit heart as a model for cardiacaging. L.L. Cooper, K.E. Odening, O. Ziv, L. Chaves, L.Schofield, B-R. Choi and G. Koren. Brown Univ. and RhodeIsland Hosp.D90 595.7 Apocynin inhibits and its removal augmentsL-type Ca 2+ currents in coronary artery smooth muscle cellsand ventricular myocytes. R. Ochi, R.S. Gupte, T. Murayama,N. Kurebayashi and S.A. Gupte. Univ. of South Alabama andJuntendo Univ., Japan.596. Cardiac Function and Dynamics IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD91 596.1 Role of iNOS in intrinsic myocyte dysfunctionduring progression of left ventricular hypertrophy. S-J. Kim, J.Chavez and G.J. Crystal. Advocate Illinois Masonic Med. Ctr.,Chicago.D92 596.2 The effects of pressure overload on cardiacgeometry and function are aggravated by aging. M. de Boer,E.D. van Deel, G.T.J. van der Horst, J.H.J. Hoeijmakersand D.J. Duncker. Erasmus Med. Ctr. and Univ. Med. Ctr.Rotterdam, Netherlands.D93 596.3 Cardiac-specific Cre-recombinase causes adose-dependent transient reduction in systolic function. G.H.Smith, M.E. Hall, D.E. Stec and J.E. Hall. Univ. of MississippiMed. Ctr.D94 596.4 Standing test after the blood donation canpredict the incidence of late phase vasovagal reaction. M.Yoshida, E. Dan, S. Narita, H. Momii, T. Kadokami and S-i.Andoh. Saiseikai Futsukaichi Hosp., Japan.D95 596.5 Histone deacetylase inhibition attenuatescatecholamine-induced impairments in contractile reserve. J.T.Liles, K.M. Joly, K.K. Ida, J. Chapo and C.F. Plato. Gilead Sci.Inc., Westminster, CO.D96 596.6 Ursolic acid accentuates contractile andsecretory functions in beating rabbit atria. H.Z. Cui, H.R. Choi,K.W. Cho, D.G. Kang and H.S. Lee. Wonkwang Univ., Republicof Korea.D97 596.7 Cardiovascular effects of a nebulized b-agonistcompared to saline in healthy humans. E.C. Wong, C.M.Wheatley, N.A. Cassuto, W.T. Foxx-Lupo, A.E. Patanwalaand E.M. Snyder. Univ. of Arizona.166

sundayphysiology597. Diabetes and Insulin Resistance IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD98 597.1 Increased capacity to oxidize fatty acids doesnot prevent development of hepatic steatosis in high-fat diet fedrats. J. Ciapaite, N.M.A. van den Broek, S.M. Houten, R.J.A.Wanders, K. Nicolay, J.A.L. Jeneson and J.J. Prompers.Univ. of Technol. Eindhoven, Netherlands Consortium for Systs.Biol., The Hague and Acad. Med. Ctr., Amsterdam.D99 597.2 Ob/Ob mice but not high fat fed mice exhibitdivergent changes in atrogin-1 and Bnip3 expression in skeletalmuscle. M. Gaugler and T.H. Reynolds. Skidmore Col.D100 597.3 Imidazolines as single agent therapy fordiabetics with hypertension. L.P. Edwards, L. Crane, G.Baziard-Mouysset and T. Brown-Bryan. Loma Linda Univ.,Univ. Paul Sabatier, France and Charles Drew Univ. of Med.and Sci.D101 597.4 NADPH oxidase inhibition alleviates diabetesinducedmyocardial contractile dysfunction. N. Roe, P. Thomasand J. Ren. Univ. of Wyoming.D102 597.5 Oxidation of myocardial glutathione increasessusceptibility to ventricular arrhythmia in the aged diabeticheart. R.C. Sloan, C. Frasier, E. Anderson, C. Wingard andD.A. Brown. East Carolina Univ.D103 597.6 Central NPY deficiency does not enhance thechronic actions of melanocortin 3 and 4 receptors activationon glucose homeostasis, appetite and cardiovascular functionin diabetic mice. J.N. Freeman, J.M. do Carmo, J.E. Hall andA.A. da Silva. Univ. of Mississippi Med. Ctr.D104 597.7 Chronic and acute postprandial hyperglycemiaenhances the gene expressions of inflammatory cytokinesin the peripheral leukocytes in rats. T. Goda, S. Fujimoto, Y.Tanaka, N. Fukaya, M. Shimada and K. Mochizuki. Sch. ofFood and Nutr. Sci., Univ. of Shizuoka, Japan.D105 597.8 Quantification of inflammatory and Toll-likereceptor gene expression in insulin-resistant horses. A.M.Stokes, K. Carlisle, E. Madara, M. McGeachy, N. Lavie, M.Keowen, F. Garza and F. Andrews. Univ. of Hawaii and LSU.D106 597.9 Luteolin reduces cardiac dysfunctions andmitochondrial oxidative stress in streptozotocin-induceddiabetic rats. F. Su, S-Q. Liu, Y. Chen, F-X. Chen, H-P. Wangand Q. Xia. Zhejiang Univ. Sch. of Med., People’s Republic ofChina.D107 597.10 Mechanisms of impaired insulin signaling incalcineruin A-alpha knockout mice. J.L. Gooch, T.K. Roberts,R. Price and R.N. Reddy. Emory Univ.D108 597.11 Short term STZ-induced diabetes reduced leftventricular dysfunction and promoted morphometric, immuneand antioxidant adaptations after myocardial infarction in rats.G.O. Candido, R.H. Mendes, B. Rodrigues, K.T. Rosa, L.E.de Souza, A. Di Petta, P. Sammoniya, A. Belló-Klein, K. DeAngelis and M.C. Irigoyen. Fed. Univ. of São Paulo, Fed. Univ.of Rio Grande do Sul, Heart Inst. and Med. Sch., Univ. of SãoPaulo and São Judas Tadeu Univ., Brazil.598. Endothelial Cell Biology IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD109 598.1 Bcl-2 -/- and Bim -/- lung endothelial cellsdemonstrate aberrant adhesion and migration. C.M. Sorensonand N. Sheibani. Univ. of Wisconsin Sch. of Med. and Publ.Hlth.D110 598.2 PECAM-1 gene ablation impairs endotheliumdependentrelaxation. R.L. Sutliff, A.M. El-Ali, H.M. DeLisserand C.M. Hart. Emory Univ./Atlanta VA Med. Ctr. and Univ. ofPennsylvania.D111 598.3 Luminal endothelial lectins with affinity forN-acetylgucosamine determine flow-induced cardiac andvascular paracrine responses. R. Rubio, J. Ramiro-Díaz, A.Barajas-Espinosa, E. Chi-Ahumada, S. Pérez-Aguilar, D.Torres-Tirado, J. Castillo-Gonzalez, M. Knabb and A. Barbade la Rosa. Autonomous Univ. of San Luis Potosi, West ChesterUniv. and IPCYT, San Luis Potosi, Mexico.D112 598.4 Biochemical alterations in coronary endothelialluminal membranes during ischemia and reperfusion in isolatedperfused guinea pig hearts. M. Knabb, S. Pérez-Aguilar, D.Torres-Tirado, J. Ramiro-Díaz and R. Rubio. West ChesterUniv. and Autonomous Univ. of San Luis Potosí, Mexico.D113 598.5 Replicative senescence may be a suitablemodel for assessing in vivo endothelial cell oxidative stress andinflammation with aging in humans. C. Rippe, M. Blimline, K.Nelson and D.R. Seals. Univ. of Colorado at Boulder.D114 598.6 Isolation and characterization of lectins fromthe coronary luminal membrane. S. Perez-Aguilar, D. Torres-Tirado, J. Ramiro-Diaz, M. Knabb and R. Rubio. AutonomousUniv. of San Luis Potosi, Mexico.D115 598.7 Nerve-induced smooth muscle to endotheliumsignaling in small resistance arteries. L.W.M. Nausch, A.D.Bonev, Y. Tallini, M.I. Kotlikoff and M.T. Nelson. Univ. ofVermont and Cornell Univ.D116 598.8 AMP-activated protein kinase activationstimulates heme oxygenase-1 gene expression to promotehuman endothelial cell survival. X-m. Liu, K.J. Peyton, H.Wang, R.J. Korthuis and W. Durante. Univ. of Missouri-Columbia and Temple Univ.D117 598.9 Investigating the role of PECAM-1 in regulatingeNOS activity in response to flow. M.E. McCormick, S. Elms,D. Fulton and E. Tzima. Univ. of North Carolina at Chapel Hilland Med. Col. of Georgia.D118 598.10 Actin tethering in endothelial junctions. S.K.Quadri, L. Sun and J. Bhattacharya. Columbia Univ.D119 598.11 Fresh frozen plasma induces nitric oxideproduction through AMPK-Akt-mediated eNOS activation. X.Deng, M-F. Doursout, Y. Cao, C. Duan, G.E. He, R.A. Kozar,J.B. Holcomb and T.C. Ko. Univ. of Texas Hlth. Sci. Ctr. atHouston.D120 598.12 Mechanical activation of Smad, a novelregulator for endothelial cell proliferation induced by disturbedflow. J. Zhou, P-L. Lee, C-I. Lee, T-L. Yang, S. Chien and J-J.Chiu. UCSD and Natl. Hlth. Res. Insts., Zhunan, Taiwan.D121 598.13 The regulation of cytokine gene expression bysphingosine 1-phosphate in endothelial cells. L. Rossi and T.Kovala. Laurentian Univ. and Northern Ontario Sch. of Med.,Canada.sun167

PhysiologyD122 598.14 Pre- and postconditioning with the mitochondrialATP-sensitive potassium channel opener BMS-191095 protectscerebral endothelial cells against oxygen glucose deprivation.A. Institoris, T. Gaspar, P.V.G. Katakam, F. Domoki, F. Bariand D.W. Busija. Wake Forest Univ. Hlth. Sci. and Univ. ofSzeged, Hungary.D123 598.15 Isolation of microvascular endothelial cellsfrom tissues using counterflow elutriation. M.L. James andR.W. Brock. West Virginia Univ.D124 598.16 TRPC6 and TRPC1 functionally interact tomediate Ca 2+ entry in endothelial cells to induce lung vascularpermeability. M. Tauseef, N. Knezevic, V. Kini, S.M. Vogel,L. Birnbaumer, A.B. Malik and D. Mehta. Univ. of Illinois atChicago and NIEHS, NIH, Researdh Triangle Park.599. Extracellular Matrix and Pathologyof Cardiovascular DiseasePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD125 599.1 Intra-arterial adenoviral delivery of GFP-FRNKinhibits FAK- and PYK2 signaling following balloon injury. Y.E.Koshman, M. Chu and A.M. Samarel. Loyola Univ. Chicago,Maywood.D126 599.2 Endothelial beta1 integrins regulate sproutingand network formation during vascular development. D. Wenzel,D. Malan, A. Schmidt, C. Geisen, A. Raible, B. Bölck, B.K.Fleischmann and W. Bloch. Univ. of Bonn, German SportUniv., Cologne and Univ. Med. Ctr. Cologne.D127 599.3 Caveolin-1 negatively regulates ametalloprotease-dependent EGF receptor transactivation byangiotensin II. A. Takaguri, H. Shirai, A. Hinoki, V. Rizzo andS. Eguchi. Temple Univ. Sch. of Med.D128 599.4 Inhibition of matrix metalloproteinase-9reverses changes in vascular wall structure and function ofthoracic aorta of Dahl salt-sensitive rats. W.E. Rodriguez-Alvarez, N. Tyagi, U. Sen, A.S. Adeagbo, I.G. Joshua andS.C. Tyagi. Univ. of Louisville and Commonwealth Med. Col.,PA.D129 599.5 The role of P2Y2 receptor activation in profibroticresponses of cardiac fibroblasts. D. Lu, O.Ö. Braun, N.Aroonsakool and P.A. Insel. UCSD.D130 599.6 Functional heterogeneity in vascularremodeling (MMP-9 -/- and PAR-1 -/+ ) in hyperhomocysteinemic(CBS -/+ ) and diabetic (Akita, Ins2 -/+ ) mice. S. Givvimani, R.Jala, P.K. Mishra, U. Sen, N. Tyagi, N. Qipshidze, C. Munjal,M. Kandel and S.C. Tyagi. Univ. of Louisville.D131 599.7 Atorvastatin attenuates Sox9 joint and cardiaccalcification in ApoE null mice. J. Park, A. Flores, N. Basu, B.Krueger and N.M. Rajamannan. Northwestern Univ. FeinbergSch. of Med.D132 599.8 Fibroblasts migrate faster in the direction ofapplied tension in a collagen-fibrin wound model. A.D. Rouillardand J.W. Holmes. Univ. of Virginia.D133 599.9 IL-1b and TNF-a differentially regulate lysyloxidase expression and activity in adult cardiac fibroblasts.T.G. Voloshenyuk and J.D. Gardner. LSU Hlth. Sci. Ctr., NewOrleans.sundayD134 599.10 3-Azidopropylamine is an excellent substrateof lysyl oxidase. N.B. Pestov, I.A. Okkelman, S.V. Kutiakov,I.A. Prokhorenko and V.A. Korshun. Shemyakin-OvchinnikovInst. of Bioorganic Chem., Moscow.D135 599.11 Tissue-engineered cardiac stem cell grafts forrepairing heart with myocardial infarction. D-H. Kim, R. Smith,K. Gupta, P. Kim, K-Y. Suh, E. Marban and A. Levchenko.Johns Hopkins Univ., Seoul Natl. Univ. and Cedars-Sinai Med.Ctr.D136 599.12 Inhibition of nuclear factor of activated T cellsreduces diabetes-induced atherosclerosis. A.V. Zetterqvist,L.M. Nilsson-Berglund, J. Nilsson, E. Bengtsson and M.F.Gomez. Lund Univ., Sweden.D137 599.13 Compensatory response of cardiac lysyloxidase to chronic volume overload. J.D. Gardner, T.G.Voloshenyuk and J.M. Bradley. LSU Hlth. Sci. Ctr., NewOrleans.D138 599.14 Sex-based differences in ventricular collagenprofile of spontaneously hypertensive rats. J. Krontiris-Litowitzand B. Fulton. Youngstown State Univ.D139 599.15 Macrophage PPAR-g in post-myocardial infarctremodeling. L.C. Katwa, M.W. Nichols, J.A. Virag, C.J. Carr,A.N. Gould and R.M. Lust. East Carolina Univ. Brody Sch. ofMed.D140 599.16 p38 MAPK-dependent MMP regulation duringcoronary collateral growth. T.Y. Dodd, R. Jadhav, E. Smithand P. Rocic. Univ. of South Alabama.600. Matrix Metalloproteinases inMitochondrial, Cytoskeletal andNuclear RemodelingPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD141 600.1 SPARC regulates early fibroblast responses tomyocardial infarction. S.M. McCurdy, Q. Dai, A.D. Bradshawand M.L. Lindsey. St. Mary’s Univ., TX.D142 600.2 Adenosine A3 receptor agonists inducefavorable alterations in the MMP/TIMP response in skeletalmuscle following traumatic injury. M.L. Urso, R. Wang, E.J.Zambraski and B.T. Liang. U.S. Army Res. Inst. of Envrn.Med., Natick, MA and Univ. of Connecticut Hlth. Ctr.D143 600.3 Flow-induced mechanotransmission from theendothelial cytoskeleton to extracellular matrix. R.E. Evans,R.E. Mott and B.P. Helmke. Univ. of Virginia and Univ. ofPennsylvania.D144 600.4 A fibronectin fragment elicits vasodilatation andalters myogenic responsiveness of skeletal muscle arterioles.J-T.S. Chao, G.E. Davis and M.J. Davis. Univ. of Missouri-Columbia.D145 600.5 Folic acid mitigated cardiac dysfunction bynormalizing the levels of tissue inhibitor of metalloproteinaseand homocysteine-metabolizing enzymes post myocardialinfarction in mice. N. Qipshidze, N. Tyagi, U. Sen, S. Givvimani,N. Metreveli, O.A. Abe, D. Lominadze and S.C. Tyagi. Univ. ofLouisville.168

sunday601. Myocardial Ischemia/MyocardialMetabolism IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD146 601.1 Diabetes does not alter contractile function inhibernating myocardium of conscious swine. S. Sharma, S-H.Yoon, J. Cook, M.M. Saad, W. Eom, G.J. Crystal and S-J.Kim. Advocate Illinois Masonic Med. Ctr., Chicago.D147 601.2 Phosphoproteomic profile of differentiallyphosphorylated proteins in human myocardium before andafter cardiac surgery utilizing cardioplegia and cardiopulmonarybypass. R.T. Clements, A.R. Ivanov, G. Smejkal, C. Bianchiand F.W. Sellke. Rhode Island Hosp., Brown Med. Sch. HarvardSch. of Publ. Hlth. and Harvard Catalyst.D148 601.3 Insulin resistance as a mechanism of preservedmyocardial function in heart failure animals fed a high fat diet.B.A. Christopher, H-M. Huang, T.A. McElfresh, X. Chen,R.F. Muzic, C.M. Croniger and M.P. Chandler. Case WesternReserve Univ.D149 601.4 High dietary sugar exacerbates cardiacreperfusion injury in perinatal taurine-depleted adult rats. S.Roysommuti, S. Kulthinee, D. Jirakulsomchok and J.M.Wyss. Khon Kaen Univ., Thailand and Univ. of Alabama atBirmingham.D150 601.5 Effects of exercise training on cardiacmitochondrial apoptosis in ovariectomized rats. C-C. Hsu, H-C.Ou and S-D. Lee. China Med. Univ., Taiwan.D151 601.6 Rapamycin (sirolimus)–induced protectionagainst ischemia-reperfusion injury is mediated throughAMPK, Akt and JAK/STAT pathways in mouse heart. A. Das,F.N. Salloum, L. Xi, E. Mayton, S.K. Desai, R.A. Ockaili andR.C. Kukreja. Virginia Commonwealth Univ.D152 601.7 Protection of cardiomyocytes by anestheticpreconditioning involves endothelial cell-derived nitric oxide.T.M. Leucker, M. Bienengraeber, A.K. Brzezinska, P.F. Prattand D.C. Warltier. Med. Col. of Wisconsin.D153 601.8 PAR1 inhibition does not enhance thecardioprotective effect of postconditioning. R. Jiang, C.Rutledge, W. Shi, R.A. Guyton and J. Vinten-Johansen.Emory Univ.D154 601.9 Ranolazine delays Ca 2+ -induced mitochondrialpermeability transition pore opening and membrane potentialdepolarization in guinea pig heart mitochondria. M. Aldakkak,A.K.S. Camara, J.S. Heisner, A.K. Gadicherla, A.D. Boelens,M. Yang, R.K. Dash and D.F. Stowe. Med. Col. of Wisconsin.D155 601.10 Hypoxia inducible factor-1 protects againstnitrate tolerance and stunning in cardiac myocytes. H.R. Weissand T. Tan. UMDNJ-Robert Wood Johnson Med. Sch.D156 601.11 Inhibition of phosphodiesterases preventsmitochondrial permeability transition pore opening byinactivating GSK-3b via PKA and PKG in cardiac cells. G.Chanoit, S. Lee, R. McIntosh, D.A. Zvara and Z. Xu. Univ. ofNorth Carolina at Chapel Hill.D157 601.12 Life-long caloric restriction confers pronouncedAMPK-dependent cardioprotection. A.G. Edwards, A.J.Donato, L.A. Lesniewski, R.A. Gioscia, D.R. Seals and R.L.Moore. Univ. of Colorado at Boulder.D158 601.13 Mitigation of heart failure progression withsildenafil involves inhibition of RhoA/Rho-kinase pathway. F.N.Salloum, V.Q. Chau, N.N. Hoke, A. Abbate and R.C. Kukreja.Virginia Commonwealth Univ.physiology602. Reactive Oxygen Species in VascularTone and RemodelingPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD159 602.1 Reactive oxygen species inhibit vascularKATP channel via S-glutathionylation. Y. Yang, W. Shi, N. Cui,X. Chen, Y. Zhang, T.C. Trower and C. Jiang. Georgia StateUniv.D160 602.2 Role of superoxide in endothelium-dependentdilation of soleus feed arteries in young and old rats. D.W. Trott,J.W. Seawright and C.R. Woodman. Texas A&M Univ.D161 602.3 Endothelial mechanotransduction with loss ofshear is a signal for angiogenesis. S. Chatterjee, N. Hong, K.Yu and A.B. Fisher. Univ. of Pennsylvania.D162 602.4 Hypoxia reduces cerebrovascular myogenicreactivity in diabetes. A.I. Kelly-Cobbs and A. Ergul. Med. Col.of Georgia and Univ. of Georgia Col. of Pharm.D163 602.5 Modifications of coronary vascular reactivitydue to a non-enzymatic reaction between vitamin C andimidazole. K. Tiwari, B. Kipp and F. Sylvester. Grand ValleyState Univ.D164 602.6 Effect of nitric oxide synthase and growthconditions on hydrogen peroxide production in culturedendothelial cells during shear stress. N.S. Zinkevich and D.D.Gutterman. Med. Col. of Wisconsin and Zablocki VA Med. Ctr.D165 602.7 Palmitate evokes ceramide-dependent reactiveoxygen species generation from sources other than NADPHoxidase in bovine aortic endothelial cells. Q. Zhang, L. Wilson,D. Pettey, C. Arrant, C. Kowalski, E.D. Abel and J.D. Symons.Col. of Hlth., Univ. of Utah.D166 602.8 NADPH oxidase-derived superoxideupregulates intermediate-conductance Ca 2+ -activated K +channel (KCa3.1) expression in vascular smooth muscle cells.H. Gole and D.K. Bowles. Univ. of Missouri-Columbia.D167 602.9 Local regulation of L-type calcium channelsby reactive oxygen species. G.C. Amberg, S. Earley and S.A.Glapa. Colorado State Univ.D168 602.10 A kinetic model of endothelial dysfunction fromthe NOS NO synthesis biochemical pathway. S. Kar and M.Kavdia. Univ. of Arkansas.603. Vascular Smooth Muscle IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD169 603.1 Cyclin D1 is a bona fide target gene of NFATc1and is sufficient in the mediation of injury-induced vascularwall remodeling. D. Wang, M. Karpurapu, D.V. Quyen, V.Kundumani-Sridharan, S. Pulusani and G.N. Rao. Univ. ofTennessee Hlth. Sci. Ctr., Memphis.D170 603.2 BAY 41-2272 reduces vascular smooth musclecell growth via PK-G and PK-A signals. T.A. Brown, N.N.Mendelev, J.C. Fox, C.N. Joshi and D.A. Tulis. South CentralH.S., Winterville, NC, North Carolina Central Univ. and BrodySch. of Med., East Carolina Univ.169sun

PhysiologyD171 603.3 Salvianolic acid B inhibits stromal cell-derivedfactor-1/CXCR4 axis and promotes apoptosis on vascularsmooth muscle cells. C-H. Wu and C-H. Pan. China Med. Univ.,Taiwan.D172 603.4 An ethyl acetate extract from a subaleuronelayer of Japanese rice inhibits angiotensin ll–induced signaltransduction and hypertrophy in vascular smooth muscle cells.A. Takaguri, H. Utsnomiya, R. Kono, S-i. Akazawa and S.Eguchi. Temple Univ. Sch. of Med., Sch. of Med., WakayamaMed. Univ. Nagaoka Natl. Col. of Technol., Japan.D173 603.5 Increases in vascular smooth muscle stiffnesswith aging. H. Qiu, Y. Zhu, M. Gansner, C. Depre, A. Peppas,R. Resuello, F. Natividad, W. Hunter, G. Meininger, G. Genin,E. Elson, D.E. Vatner and S.F. Vatner. UMDNJ-New JerseyMed. Sch., St. Luke’s Med. Ctr. and SICONBREC, Manila, Univ.of Missouri-Columbia and Washington Univ. Sch. of Med.D174 603.6 PDGF-induced vascular smooth muscle cellmigration is regulated by coronin 1b. H.C. Williams, A. SanMartin and K.K. Griendling. Emory Univ. Sch. of Med.D175 603.7 Mitochondria control NF-kB-dependentfunctional Ca v1.2 expression in cerebral artery smooth musclecells. D. Narayanan, Q. Xi, L. Pfeffer and J. Jaggar. Univ. ofTennessee Hlth. Sci. Ctr., Memphis.D176 603.8 O-GlcNAcylation augments protein kinase Cmediated vasoconstriction. D. Hardy, R.C. Tostes and R.C.Webb. Med. Col. of Georgia and Univ. of São Paulo.D177 603.9 Modulation of calcium channel subunitexpression in vascular smooth muscle cells by transfection withb subunit constructs. S. Telemaque, S.E. Flynn, K.B. Meredith,M. Liu, A.J. Davidoff and J.D. Marsh. Univ. of Arkansas forMed. Sci. and Univ. of New England.D178 603.10 Zipper-interacting protein kinase: inferringfunction in smooth muscle contractility by identifying bona fidesubstrates. L.D. Moffat, M. Walsh and J. MacDonald. Univ. ofCalgary.D179 603.11 S-nitrosylation decreases vasodilation viaguanylyl cyclase inhibition in mouse aorta. H. Choi and R.C.Webb. Med. Col. of Georgia.D180 603.12 ET-1-induced vascular contraction is mediatedby RhoA/Rho-kinase pathway activation via O-GlcNAcylation.V.V. Lima, F.R. Giachini, R.C. Webb and R.C. Tostes. Univ. ofSão Paulo and Med. Col. of Georgia.D181 603.13 Deletion of Jak2 tyrosine kinase within vascularsmooth muscle cells attenuates angiotensin II-inducedhypertension in mice. A. Kirabo, P. Kearns, J. Sasser, A.J.Cardounel, C. Baylis, K-U. Wagner and P.P. Sayeski. Univ. ofFlorida and Univ. of Nebraska Med. Ctr.D182 603.14 The putative TRPM4 blocker 9-phenanthrolcauses smooth muscle cell hyperpolarization and arterialdilation. Z.I. Garcia, A.L. Gonzales and S. Earley. ColoradoState Univ.D183 603.15 Disruption of caffeine-induced constrictionin isolated cerebral arteries following treatment with siRNAagainst STIM 1. A.L. Gonzales and S. Earley. Colorado StateUniv.D184 603.16 Caveolae are necessary for functional I Catactivation by IP 3Rs in cerebral artery smooth muscle cells. A.Adebiyi and J.H. Jaggar. Univ. of Tennessee Hlth. Sci. Ctr.,Memphis.D185 603.17 Expression of KCa2.x and KCa3.1 channelsin vascular smooth muscle cells from mouse portal vein. A.Blanchette, C. Charbel and J. Ledoux. Montreal Heart Inst.and Univ. of Montreal.sunday604. Cerebral Blood Flow and Ischemia/Neuroinflammation/NeuroprotectionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD186 604.1 Caveolae/lipid raft modulates TNF-alphainducedupregulation of cell adhesion molecules in humanbrain endothelial cells. S.Y. Eum, I.E. Andras, Y.J. Choi, B.Hennig and M. Toborek. Univ. of Kentucky.D187 604.2 Ischemia/ reperfusion injury causes an outwardremodeling of the middle cerebral artery. J.M. Osmond andA.M. Dorrance. Med. Col. of Georgia and Michigan StateUniv.D188 604.3 Dihydrotestosterone attenuates HIF-1alpha andCOX-2 in cerebral arteries following hypoxia. K.L. Osterlund,R.J. Handa and R.J. Gonzales. Univ. of Arizona Col. of Med.,Phoenix.D189 604.4 Tetrahydrocurcumin ameliorates mtMMP-9-mediated mitophagy and mitochondria remodeling in stroke. N.Tyagi, N. Qipshidze, S. Givvimani, M. Kandel, P.K. Mishra, U.Sen, A. Johar and S.C. Tyagi. Univ. of Louisville.D190 604.5 Influences of alcohol consumption on transientfocal cerebral ischemia. H. Sun, W. Xiong, H. Zhao, G.M.Sharpe, D.M. Arrick and W.G. Mayhan. Univ. of NebraskaMed. Ctr.D191 604.6 Acid-sensing ion channel 1 is expressedin cerebral arteries and located near neuronal nitric oxidesynthase. L-H. Lin and W.T. Talman. Univ. of Iowa and VA Hlth.Care Syst.D192 604.7 The aryl hydrocarbon receptor upregulatesP-glycoprotein at the blood-brain barrier. D.S. Miller and X.Wang. NIEHS, NIH, Research Triangle Park.D193 604.8 Beta-amyloid is removed from the brain CSF bya nondiffusion process. C. Thompson and J.S. Crossgrove.Ohio Northern Univ.D194 604.9 Uptake of folates by rat and human brainendothelial cell lines. J.R. Araújo, P. Gonçalves and F. Martel.Fac. of Med., Univ. of Porto, Portugal.D195 604.10 Tea, coffee and caffeinated drink consumptionand risk of subclinical brain abnormalities on MRI. L. Arab, W.Lonstreth, E.S. O’Meara, K. Mukamal and D. Liebeskind.David Geffen Sch. of Med. at UCLA, Univ. of Washington, BethIsrael Deaconness Med. Ctr. and UCLA Stroke Ctr.D196 604.11 Mannose binding lectin modulates cerebralinjury after ischemic stroke and reperfusion. H.W. Morrison, D.McKee, P. McDonagh and L. Ritter. Univ. of Arizona.D197 604.12 Neural activity in hippocampal slices fromhibernating Syrian hamsters (Mesocricetus auratus) is moretolerant to anoxia than slices from nonhibernating hamsters.J.S. Tan, R. Singh, K.C. Taylor, J.S. Hamilton, J.M. Horowitzand B.A. Horowitz. Univ. of California, Davis.D198 604.13 Transfection of parasympathetic ganglionicneurons with AAV2-nNOScDNA protects rat brain from stroke.W.T. Talman, D. Easker, D. Nitschke Dragon and L-H. Lin.Univ. of Iowa and VA Med. Ctr.D199 604.14 4,4-Diisothiocyanatostilbenedisulphonic acidis cytotoxic and does not provide protection against ischemicinsults in cultured neurons or astrocytes. M. Pamenter, X. Gu,M. Yoon, G. Perkins, M. Ellisman and G. Haddad. UCSD.170

sundayD200 604.15 Protective effect of apigenin on neuronsagainst oxygen-glucose deprivation/reperfusion-induced injury.S-Q. Liu, F. Su, L-M. Fang, Q. Xia and X. Zhang. ZhejiangUniv. Sch. of Med., People’s Republic of China.D201 604.16 A role of the novel, non-AT1, non-AT2angiotensin binding site in neuronal cell death. M.M. Rashid,T.V. Arumugam and V.T. Karamyan. Sch. of Pharm., TexasTech Univ. Hlth. Sci. Ctr., Amarillo and Sch. of Biomed. Sci.,Univ. of Queensland.D202 604.17 The dietary flavonoid quercetin decreasesneuroinflammation in a mouse model of Alzheimer’s disease.S.H. Jung, E.A. Murphy, J.L. McClellan, M.D. Carmichaeland J.M. Davis. Univ. of South Carolina.D203 604.18 Effects of an anoxic insult on hamsterhippocampal CA1 pyramidal cells are attenuated withdecreasing temperature. T.A. Brown, C.J. Lewis, G.H. Liepart,J.M. Ordaz, J.S. Hamilton, J.M. Horowitz and B.A. Horowitz.Univ. of California, Davis.D204 604.19 Curcumin mitigated ischemic andhyperhomocysteinemic cerebral microvascular mitochondrialmitophagy by decreasing oxidative and inflammatory stresses.S. Kapoor, N. Tyagi, N. Qipshidze, S. Givvimani, M. Kandeland S.C. Tyagi. Univ. of Louisville.D205 604.20 Brain MCPp-1 is elevated in a mouse model ofcancer-related fatigue. B.T. Gordon, A. Murphy, J.L. McClellan,M. Carmichael and M. Davis. Univ. of South Carolina.605. Renin-Angiotensin System in Regulationof Blood Pressure and Renal FunctionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD206 605.1 Antenatal steroid exposure is associated withreduced urinary ACE2 activity in adolescents. T.M. Gwathmey,H.A. Shaltout, P.A. Nixon, J.C. Rose, L.K. Washburn andM.C. Chappell. Wake Forest Univ. Sch. of Med. and WakeForest Univ.D207 605.2 Stimulation of the renin angiotensin system inan early stage of life causes sustained hypertension in rats.B. Heijnen, H. van Essen, J. Debets, C. Peutz-Kootstra, P.Lijnen, B. Janssen and H. Struijker-Boudier. MaastrichtUniv., Netherlands.D208 605.3 Influence of maternal high sodium diet onsystemic and renal renin angiotensin aldosterone systemof males and females offspring Wistar rats. D.R. Ramos,N.L. Costa, K.L. Lopes Jang, I.B. de Oliveira and L.N.S.Furukawa. Univ. of São Paulo.D209 605.4 Chymase-dependent generation of angiotensinII from angiotensin-(1-12) in human atrial tissue. S. Ahmad,J. Varagic, B. Westwood, M.C. Chappell, W.B. Strawn, T.Simmons and C.M. Ferrario. Wake Forest Univ. Sch. of Med.D210 605.5 Role of angiotensin II receptor (AT1aR) in thickascending limb of Henle’s loop and distal tubules. H. Li, D.R.Davis and C.D. Sigmund. Univ. of Iowa.D211 605.6 Immunocytochemical distribution of theAng-(1-7)/mas receptor in the sheep kidney. B. Westwood,T.M. Gwathmey, H.A. Shaltout, D. Diz, J.C. Rose and M.C.Chappell. Wake Forest Univ. Sch. of Med.physiologyD212 605.7 Expression of components of the reninangiotensinsystem in the brain of 2K1C hypertensive rats afterexercise training. L.M. Cangussu, R.A.S. Santos, A. Martins,A.C. Alzamora and M.J. Campagnole-Santos. Fed. Univ. ofMinas Gerais and Fed. Univ. of Ouro Preto, Brazil.D213 605.8 Effect of carvedilol and losartan on renalresponses to Ang II and adrenergic agonists in fructose-fedrat. M.H. Abdulla, M.A. Sattar, N.A. Abdullah, M.H. Khan,K.R.L. Anand Swarup, H.A. Rathore, Z.O. Ibraheem and E.J.Johns. Univ. Sains Malaysia, Univ. Malaya, Tulane Univ. andUniversity Col. Cork.D214 605.9 The role of kidney on sodium balancein angiotensin II-induced hypertension. C.S.R. Ferreira-Figueiredo and M. Oliveira-Souza. Univ. of São Paulo.D215 605.10 Renin-angiotensin-aldosterone system duringextracorporeal membrane oxygenation in a pig model of septicshock. T.S. Mu, S.G. Batts, A.K. Sato, C.A. Hernandez, W.Ichimura, S.L. Lentz-Kapua and C.F.T. Uyehara. Tripler ArmyMed. Ctr., Honolulu.D216 605.11 AT1 receptor-mediated augmentation of urinaryexcretion of endogenous Ang II in Val5-Ang II infused rats. W.Shao, D.M. Seth and L.G. Navar. Tulane Univ. Sch. of Med.D217 605.12 Effect of COX-2 inhibition on sodium excretionand ENaC expression in angiotensin II-induced hypertensiverats. A.A. Gonzalez, C. Cespedes, S. Villanueva and C.P. Vio.Catholic Univ. of Chile and Univ. de los Andes, Chile.D218 605.13 Kidney microRNA expression profile in AngII- dependent hypertension. R.A. Gonzalez-Villalobos, C.Kim, R.M. Neff, R. Satou and L.G. Navar. Tulane Univ. Sch. ofMed.D219 605.14 AT1 receptor-independent oxidative stress inangiotensin II infused male spontaneously hypertensive rats..K. Bhatia and J.C. Sullivan. Med. Col. of Georgia.D220 605.15 Elevated blood pressure and abnormalevolution of pregnancy in ACE2-deficient female mice. R.V.Pimentel, R.A.S. Santos, M. Todiras, E.P. Velloso, J.F. Braga,J. Penninger, M. Bader and N. Alenina. Univ. Fed. de MinasGerais, Brazil, Max Delbruch Ctr., Berlin and Inst. of Molec.Biotechnol., Austrian Acad. of Sci., Vienna.D221 605.16 Increased urinary renin excretion rate in chronicAngII-infused rats fed a high salt diet leads to augmentedurinary Ang II levels. M. McCormack, L. Liu, D.M. Seth, H.Kobori, L.G. Navar and M.C. Prieto. Tulane Univ. Sch. ofMed.606. Ion TransportPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD222 606.1 Vasopressin triggers phosphorylation of Na-K-2Cl cotransporter NKCC1) in rat inner medullary collectingduct. C-L. Chou, E.M. Kassai and M.A. Knepper. NHLBI,NIH.D223 606.2 An essential role of cortactin in regulation ofENaC. D. Ilatovskaya, K.C. Vinnakota, T.S. Pavlov and A.Staruschenko. ‘Med. Col. of Wisconsin and Inst. of Cytol.,RAS, St. Petersburg.D224 606.3 Defining roles for P2Y 2and P2Y 4receptors onblood pressure and urinary excretion. T. Rieg, J. Schroth, P.A.Insel, J. Broyer and V. Vallon. UCSD, VA San Diego HealthcareSyst. and Inspire Pharmaceuts. Inc., Durham, NC.sun171

PhysiologyD225 606.4 Phospho-specific antibodies to Ser126 andSer874 of the apical Na-K-2Cl cotransporter demonstratevasopressin-regulated phosphorylation in the renal thickascending limb. R. Gunaratne, T. Pisitkun, D.W.W. Braucht, L.Xie, M. Rinschen, J.D. Hoffert, C-L. Chou and M.A. Knepper.NHLBI, NIH.D226 606.5 Akt/PKB-sensitive proximal tubular glucoseand phosphate transport. M. Föller, D.S. Kempe, G. Siraskar,H. Fröhlich, T.F. Ackermann, B. Siraskar, H. Völkl, M.Judenhofer, B. Pichler, K.F. Leavens, M.J. Birnbaum, D.Pearce and F. Lang. Eberhard Karls Univ. of Tübingen, Univ.of Innsbruck, Univ. of Pennsylvania and UCSF.D227 606.6 Angiotensin II-induced stimulation of NHE3 isdependent on IRBITt and CaMKII. P. He and C. Yun. EmoryUniv.D228 606.7 Angiotensin II stimulates ENaC and suppressesthe inhibitory effect of 11,12-EET on ENaC in the corticalcollecting duct. P. Sun, D. Lin, P. Yue and W. Wang. New YorkMed. Col.D229 606.8 Efficiency of sodium transport in the thickascending limb. A. Nieves-Gonzalez, L.C. Moore, C. Clausen,M. Marcano, H.E. Layton and A.T. Layton. Stony Brook Univ.,Univ. of Puerto Rico and Duke Univ.D230 606.9 Pendrin regulates ENaC abundance andfunction by modulating luminal HCO3 - concentration. V. Pech,T.D. Pham, S.M. Hong, K.B. Spencer, B.J. Duke, E. Walp, Y.H.Kim, R.L. Sutliff, D.C. Eaton and S.M. Wall. Emory Univ. Sch.of Med.D231 606.10 Ion transport homeostasis in alpha-1 AMPKKO mice. Y. Lazo, G. Baile, L. Martínez, M. Bernal, B. Violletand I. Gimenez. Univ. of Zaragoza and Aragones Inst. of Hlth.Sci., Spain, Univ. Paris Descartes and INSERM U567, Paris.D232 606.11 Disease-causing mutation R1185C altersphosphorylation of WNK4 by SGK1 via a calmodulin bindingsite. T. Na, W. Zhang, Y. Jiang and J-B. Peng. Univ. of Alabamaat Birmingham.D233 606.12 Physiological regulation of ENaC activity in thedistal nephron by local bradykinin signaling. O. Pochynyuk.Univ. of Texas Hlth. Sci. Ctr. at San Antonio.D234 606.13 Role of the cAMP/PKA signaling cascade invasopressin-induced trafficking of TRPC3 channels in principalcells of the collecting duct. M. Goel, C-D. Zuo and W.P.Schilling. Case Western Reserve Univ. and MetroHlth. Med.Ctr.D235 606.14 Role of TRPC3 channels in ATP-induced Ca 2+signaling in principal cells of the inner medullary collecting duct.M. Goel and W.P. Schilling. Case Western Reserve Univ. andMetroHlth. Med. Ctr.D236 606.15 SGLT2 mediates glucose reabsorption in theearly proximal tubule. V. Vallon, J. Schroth, K.A. Platt, J.Whaley, S. Thomson and T. Rieg. UCSD and VA San DiegoHlth. Care Syst., Lexicon Pharmaceut., Inc., The Woodlands,TX and Bristol-Myers Squibb R&D, Pennington, NJ.D237 606.16 Activation of a latent nuclear localization signalin the amino-terminus of g-ENaC initiates feedback regulationof channel activity. E. Mironova and J.D. Stockand. Univ. ofTexas Hlth. Sci. Ctr. at San Antonio.D238 606.17 Evidence for ENaC involvement in hypertensionproduced by NO1 gene deletion in the collecting duct. K.A.Hyndman, A. Elmarakby, D.M. Pollock and J.S. Pollock.Med. Col. of Georgia.sundayD239 606.18 Identification of key residues in WW domainsof ubiquitin-protein ligase Nedd4-2 that bind to calcium channelTRPV6. W. Zhang, T. Na and J-B. Peng. Univ. of Alabama atBirmingham.D240 606.19 Voltage-dependent gating underlies the PHA1phenotype caused by mutation of a conserved HG motif inENaC. V. Kucher, N. Boiko, O. Pochynyuk and J.D. Stockand.Univ. of Texas Hlth. Sci. Ctr. at San Antonio.D241 606.20 Loss of paracrine regulation of ENaC byATP signaling intrinsic to the distal nephron increases bloodpressure. O. Pochynyuk, V. Bugaj, T. Rieg, P.A. Insel, V. Vallonand J.D. Stockand. Univ. of Texas Hlth. Sci. Ctr. at San Antonioand UCSD.D242 606.21 Caveolin-1 mediates constitutive NKCC2endocytosis in thick ascending limbs. G.R. Ares and P.A. Ortiz.Henry Ford Hosp., Detroit.D243 606.22 Hypertension resistance polymorphisms inROMK alter channel function by different mechanisms. L. Fang,D. Li and P.A. Welling. Univ. of Maryland Sch. of Med.D244 606.23 Estrogen induces transient intracellular Ca 2+signals in distal renal tubules. J. Praetorius, R.A. Fenton andM.V. Hofmeister. Aarhus Univ., Denmark.D245 606.24 Kcnmb4 -/- mice have decreased tubular dilationunder high urinary flow. J.D. Holtzclaw, P.R. Grimm and S.C.Sansom. Univ. of Nebraska Med. Ctr.D246 606.25 Evidence for aldosterone-mediated regulationof Na-K ATPase in kidney proximal tubules. J. Parks, M.T.Barati, S.A. Salyer, A. Mandal, J.D. Klein and S.J. Khundmiri.Univ. of Louisville Univ. of Arizona and Emory Univ.D247 606.26 Different types of vesicle trafficking of NBCe1(SLC4A4). I.I. Grichtchenko, C.J. Perry and A.A. Bellis. Univ.of Colorado Denver, Aurora.D248 606.27 Pannexin1 is a novel renal ATP releasemechanism. F. Hanner and J. Peti-Peterdi. Univ. of SouthernCalifornia.D249 606.28 Protein kinase D1 modulates aldosteroneinducedENaC trafficking and regulation in M1 renal corticalcollecting duct cells. R. Dooley, B.J. Harvey and W. Thomas.Royal Col. of Surgeons in Ireland.D250 606.29 UCH-L3 upregulates the epithelial sodiumchannel in A6 distal nephron cells. H-F. Bao, B.J. Duke andD.C. Eaton. Emory Univ.D251 606.30 Differential regulation of NaPi2a and NaPi2cby parathyroid hormone. K. Okamura, H. Giral, Y. Caldas,E. Sutherland, A. Millard, M. Levi and J. Blaine. Univ. ofColorado Denver, Aurora.D252 606.31 ENaC expression alters a recycling vesicle poolresponsible for its regulation. M. Butterworth, R. Edinger, C.Bertrand, R.A. Frizzell and J. Johnson. Univ. of Pittsburgh.D253 606.32 Vesicle associated membrane protein (VAMP)3 but not vamp2 is involved in NKCC2 apical targeting andprocessing in thick ascending limbs. P.S. Caceres, M. Mendezand P.A. Ortiz. Henry Ford Hosp. and Wayne State Univ.D254 606.33 Glucagon-like peptide-1 downregulates Na + /H +exchanger NHE3 activity in rat renal proximal tubule. B.P.M.Pacheco, L.M.A. Lessa, F.T. Oricchio, G. Malnic and A.C.C.Girardi. Univ. of São Paulo.D255 606.34 Mutations in renal drug efflux transporterhOATv1 cause hyperuricemia. P. Jutabha, N. Anzai, K.Kitamura, A. Taniguchi, S. Kaneko, H. Yamada, W. Urano, G.Seki, H. Endou and H. Sakurai. Kyorin Univ. Sch. of Med.,Kumamoto Univ. Grad. Sch. of Med. and Pharm. Sci.,TokyoWomen’s Med. Univ., Kyoto Univ. Grad. Sch. of Pharm. Sci. andUniv. of Tokyo.172

sundayD256 606.35 Disruption of sodium and water balance in k + -adapted BKb4 -/- mice. P.R. Grimm, J.D. Holtzclaw, D.L. Irsik,L. Liu and S.C. Sansom. Univ. of Nebraska Med. Ctr.D257 606.36 Role of SPAK binding sites in SLC12cotransporters basal activity and regulation by WNK3. D.Pacheco-Alvarez, P. De-los-Heros, J. Ponce-Coria, N.Vazquez, P. Ortal-Vite, E. Rodriguez-Lobato and G. Gamba.Univ. Panamericana, Mexico and Natl. Autonomous Univ. ofMexico.607. ATPase Ion PumpsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD258 607.1 Reversible glutathionylation of theplasmalemmal Ca 2+ -ATPase/pump by the thiol-oxidizing agentdiamide. W.G. Sinkins and W.P. Schilling. Case WesternReserve Univ. and MetroHlth. Med. Ctr.D259 607.2 Gastric H + /K + ATPase beta subunit in thecolonic H + /K + ATPase knockout mice. G. Wei, S. Higashi and S.Nakamura. Murray State Univ.D260 607.3 Agrin C20 peptide provides neuroprotection byactivating a Na,K-ATPase/inositol 1,4,5-trisphosphate receptorsignaling pathway. Z. Spicarova, X.L. Liu, A. Bondar and A.Aperia. Karolinska Inst., Solna and Inst. of Chem. Biol. andFundamental Med., Novosibirsk, Russia.D261 607.4 Isoforms of Na, K-ATPase in epithelial andendothelial barriers in the equine hoof. K. Asplin and A.Mobasheri. Univ. of Nottingham.D262 607.5 N-terminal a2 Na + pump constructs aredominant negative for native a2 Na + pumps in smooth, butnot cardiac muscles, and increase salt sensitivity. H. Song, L.Chen, J.C. Lee, M.I. Kotlikoff, W.J. Lederer, C.A. Frederick,E. Karaashima, W.C. Randall and M.P. Blaustein. Univ. ofMaryland Sch. of Med., Cornell Univ. Col. of Vet. Med. and Univ.of Maryland Biotechnol. Inst.D263 607.6 Sorting of a2 and a3 Na + pumps in glia andneurons: linkage with Na/Ca exchanger-1. H. Song, D.J. Weber,S.M. Thompson and M.P. Blaustein. Univ. of Maryland Sch. ofMed.D264 607.7 Critical role of the isoform-specific regionin Na,K-ATPase trafficking and protein kinase C-dependentregulation. S.V. Pierre, Y. Sottejeau, A. Belliard, M-J. Duranand T.A. Pressley. Univ. of Toledo Hlth. Sci. Campus and TexasTech Univ. Hlth. Sci. Ctr.608. Ion ChannelsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD265 608.1 Possible role of adaptor proteins in thetrafficking of hIK1. J. McKenzie and K.L. Hamilton. Univ. ofOtago, New Zealand.D266 608.2 I K1a crucial component of repolarizationreserve is modulated by shifts in [Ca 2+ ] i. A. Toth, N. Nagy, L.Virag and A. Varro. Univ. of Szeged, Hungary.D267 608.3 Inhibition of murine macrophage inwardlyrectifying Kir2.1 channels by gambogic acid. Z. O’Bryant andM. Colden. Morehouse Sch. of Med.physiologyD268 608.4 Angiotensin II – PKC-mediated translocationof the BK-b1 subunit to the basolateral membrane of principalcells. L. Liu, P.R. Grimm, J.D. Holtzclaw, D.L. Irsik and S.C.Sansom. Univ. of Nebraska Med. Ctr.D269 608.5 An extended di-isoleucine motif mediatesKir2.3 endocytosis via direct binding to the AP-2 adaptin a/s2subunits. B. Ortega, A.K. Mason and P.A. Welling. Univ. ofMaryland Sch. of Med.D270 608.6 Golgi trafficking defect in channelopathyreveals a new cargo selection mechanism. T.K. Taneja, D. Ma,B.M. Hagen, B-Y. Kim, J. Lederer and P.A. Welling. Univ. ofMaryland Baltimore and Univ.of Maryland Biotechnol. Inst.D271 608.7 Regulation of migration and proliferation ofglioma cells by modulating the ion channel activity. A.K. Rooj,C.M. Fuller and D.J. Benos. Univ. of Alabama at Birmingham.D272 608.8 Gating-associated conformational changesin the pore of ASIC1a. L.A. Tolino, S. Okumura and M.D.Carattino. Univ. of Pittsburgh.D273 608.9 An ASIC1 and ENaC hybrid channel is theamiloride sensitive channel in human glioma. N. Kapoor, W.Lee, V. Parpura, C.M. Fuller, C.A. Palmer and D.J. Benos.Univ. of Alabama at Birmingham.D274 608.10 Acid–induced currents in freshly isolatedcerebral artery smooth muscle cells are predominatelyconducted by ASIC1b. W-S. Chung, A. Swenson, J.M. Farleyand H.A. Drummond. Univ. of Mississippi and Med. Ctr.D275 608.11 Small molecule inhibitors of acid sensing ionchannel-1. Y.J. Qadri, Y.H. Song, C.M. Fuller and D.J. Benos.Univ. of Alabama at Birmingham.D276 608.12 Functional characterization of TMEM16 anionchannels. G. Owsianik, J. Prenen, D. Hermans, J. Eggermontand B. Nilius. Katholieke Univ. Leuven, Belgium.D277 608.13 Defective cAMP-dependent HCO 3-secretionleads to abnormal mucus. N. Yang, M.A.S. Garcia and P.M.Quinton. UCSD and Univ. of California, Riverside.D278 608.14 Isoform-dependent modification of T-typecalcium channels by ProTxII. E.O. Hall, G.B. Edgerton, K.M.Blumenthal and D.A. Hanck. Univ. of Chicago and Univ. atBuffalo, SUNY.D279 608.15 Promotion of trafficking and sensitivity to DAGare involved in TRPC6 channel activation by hydrogen peroxide.S.M. Graham, M. Ding, R. Luchowski, Z. Gryczynski and R.Ma. Univ. of North Texas Hlth. Sci. Ctr.D280 608.16 TMEM16A contributes to Ca 2+ -activated Cl -secretion in the renal collecting duct. P. Svenningsen. Univ. ofSouthern California.609. Transporters: Ions, Transmitters,Nutrients, Metabolites, and DrugsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD281 609.1 Sphingosine-1-phosphate acutely modulatesthe cystic fibrosis transmembrane regulator transporter in anAMPK-dependent manner. F.A. Malik, A. Meissner, C. Bearand S.S. Bolz. Univ. of Toronto and Hosp. for Sick Children.D282 609.2 Substrate specificity of organic aniontransporter 2: a tale of different expression systems? R.M.Pelis. Novartis Insts. for Biomed. Res.D283 609.3 On the substrate recognition and autoinhibitorydomain of SPAK. K.B. Gagnon and E. Delpire. Vanderbilt Univ.Med. Ctr.173sun

PhysiologyD284 609.4 Effect of AQP1 knockout on mouse exercisetolerance. L. Xu, Y. Zhou, N.A. Courtney, T.S. Radford andW.F. Boron. Sch. of Med., Case Western Reserve Univ.D285 609.5 Placenta copper transport proteins inpreeclampsia. C.V. Iseminger, C.M. Anderson and W.T.Johnson. Univ. of North Dakota and USDA, Grand Forks.D286 609.6 GATMD: g-aminobutyric acid transportermutagenesis database. P.D. Kidd, C.M. Anderson, N. Musterand S. Eskandari. California State Polytech Univ., Pomona.D287 609.7 Mapping critical structural elements in divalentmetal-ion transporter-1. J.H. Alexander, A. Shawki, J. Mellerand B. Mackenzie. Univ. of Cincinnati Col. of Med.D288 609.8 PCR cloning of a divalent metal transporterfrom malaria mosquito Anopheles gambiae tissue cDNA library.A. Mandal, M. Charles, J. Dines, L. Merritt, D. Singleton, R.Brookings, E. Meleshkevitch, D. Boudko and P.K. Mandal.Edward Waters Col., FL and Rosalind Franklin Univ. of Med.and Sci.D289 609.9 Role of KCC3 in high-grade glioma migration.K.B. Gagnon and E. Delpire. Vanderbilt Univ. Med. Ctr.D290 609.10 C-terminal threonines in the KCC4 K-Clcotransporter confer sensitivity to cell volume. A. Mercado,E. Babilonia, K.B. Gagnon, A. Mandal, E. Delpire and D.B.Mount. Brigham and Women’s Hosp., Harvard Med. Sch., Natl.Cardiol. Inst. Ignacio Chavez, Mexico City, Vanderbilt Univ. Med.Ctr. and VA Boston Healthcare Syst.D291 609.11 Molecular determinant(s) of hyperosmoticallyactivated NKCC1-mediated K + /K + exchange. K.B. Gagnon andE. Delpire. Vanderbilt Univ. Med. Ctr.D292 609.12 Na + /H + -exchanger-1 inhibition reversesperipheral diabetic neuropathy. S. Lupachyk, P. Watcho, Y.Maksimchyk, H. Shevalye, C. Oltman, M.A. Yorek and I.G.Obrosova. Pennington Biomed. Res. Ctr., LSU and DVA Med.Ctr., Iowa City.D293 609.13 A role for C-terminal cysteines in oligomerizationof the Slc26a6 anion transporter. Q. Li, E. Babilonia, M-H.Chang, C. Kwon, A. Mandal, A. Mercado, M.F. Romero andD.B. Mount. Brigham and Women’s Hosp., Harvard Med. Sch.,Mayo Clin. Sch. of Med. and VA Boston Healthcare Syst.610. Epithelial Ion ChannelsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD294 610.1 Regulation of podocyte Slo1 BK channels bysynaptopodin. E.Y. Kim, P. Mundel and S.E. Dryer. Univ. ofHouston and Univ. of Miami Miller Sch. of Med.D295 610.2 Angiotensin II diminishes the effect of SGK1 onWNK4-mediated inhibition of ROMK1 channels. P. Yue, D. Lin,C. Pan, P. Sun and W. Wang. New York Med. Col.D296 610.3 Vasopressin independent trafficking ofaquaporin-2 by prostaglandin E2. E.T.B. Olesen, H.B. Moeller,S. Nielsen, J. Frøkiær, H.A. Praetorius and R.A. Fenton.Univ. of Aarhus and Aarhus Univ. Hosp., Denmark.D297 610.4 Aquaglyceroporins in epithelial and endothelialbarriers in the equine hoof. K. Asplin and A. Mobasheri. Univ.of Nottingham.D298 610.5 Effect of DIDS and pCMBS on the CO 2permeability of human aquaporin-5. X. Qin and W.F. Boron.Case Western Reserve Univ.sundayD299 610.6 KCNE1-induced increase in KCNQ1 currentsis not mediated through enhanced membrane expression.S. Hammami, D.A. Klaerke and N.J. Willumsen. Univ. ofCopenhagen.D300 610.7 Regulation of plasma membrane expressionofTRPV4 channel by GSK1016790A and hypotonic stress inHeLa and M-1 cells. M. Jin, J. James and R.G. O’Neil. Univ. ofTexas Hlth. Sci. Ctr. at Houston.D301 610.8 Characteristics of mucosal intermediateconductance K + (KCNN4) channels in rat intestinal epithelialIEC18 cells. V.M. Rajendran and W.F. Wonderlin. West VirginiaUniv. Sch. of Med.D302 610.9 Inhibition of tyramine signaling by cGMPin Drosophila Malpighian tubules. K.A. Ruka and E.M.Blumenthal. Marquette Univ.D303 610.10 A cAMP-activated Cl - channel in the apicalmembrane of chick (Gallus gallus) proximal tubule cells. G.Laverty, V. Reddy and S.S. Árnason. Univ. of Delaware andUniv. of Iceland.D304 610.11 Saponin selectively permeabilizes the sweatduct basolateral membrane. M.M. Reddy. UCSD.D305 610.12 Effects of TMEM16A expression on motilityand metastasis in epithelial tumor cells. D.J. Shiwarski, L.M.He, X. Huang, S. Gollin, J. Grandis and U. Duvvuri. Univ. ofPittsburgh Med. Ctr.D306 610.13 Glucose stimulates BK channels in humanpodocytes. W-T. Huang and H-P. Ma. People’s Hosp. ofGuangxi, People’s Republic of China and Univ. of Alabama atBirmingham.D307 610.14 A Pseudomonas aeruginosa toxin (Cif) reducesplasma membrane CFTR by inactivating the deubiquitinatingenzyme USP10. J. Bomberger, S. Ye, G. O’Toole and B.Stanton. Dartmouth Med. Sch.D308 610.15 SGK1 increases plasma membrane CFTRin human airway epithelial cells. J. Bomberger, D. Sato, B.Coutermarsh, R. Barnaby, M.C. Chapline and B. Stanton.Dartmouth Med. Sch. and Mount Desert Island Biol. Lab.,Salisbury Cove, ME.D309 610.16 The Ca 2+ -activated Cl - channel TMEM16Arepresents the effector pathway for purinergic receptormediatedsecretion in liver epithelium. A.K. Dutta, A-K. Khimji,M. Dougherty, C. Kresge, K. Woo, V. Esser, G. Alpini and D.Rockey. Univ. of Texas Southwestern Med. Ctr. and Texas A&MHlth. Sci. Ctr. Col. of Med., Temple.D310 610.17 b-Adrenergic activation of Cl secretion andK secretion in guinea pig distal colonic mucosa proceeds viaseparate receptor complexes. S. Halm, J. Zhang and D. Halm.Wright State Univ. Boonshoft Sch. of Med.D311 610.18 Inhibition of Na + transport in mouse lungexposed to chlorine. A. Lazrak, L. Cain, S. Doran and S.Matalon. Univ. of Alabama at Birmingham.611. Epithelial Sodium ChannelsPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD312 611.1 EGF and its related growth factors mediatesodium transport in mpkCCD c14cells via ErbB2 (neu/HER-2) receptor. N.N. Zheleznova, V. Levchenko, T.S. Pavlov, A.Vandewalle, P.D. Wilson and A. Staruschenko. Med. Col. ofWisconsin and INSERM, Paris.174

sundayD313 611.2 WAVE proteins mediate ENaC activity. A.V.Karpushev, V. Levchenko and A. Staruschenko. Med. Col. ofWisconsin.D314 611.3 Effects of cytochrome P450 metabolites ofarachidonic acid on the epithelial sodium channel. T.S. Pavlov,D. Ilatovskaya, R.J. Roman and A. Staruschenko. Med. Col.of Wisconsin, Inst. of Cytol., RAS, St. Petersburg and Univ. ofMississippi Med. Ctr.D315 611.4 Regulation of ENaC by the cytoskeleton. M.S.Reifenberger, B.J. Duke, L. Yu and D.C. Eaton. Emory Univ.D316 611.5 8-CPT-cAMP is a self-inhibition reliever forENaC expressed in Xenopus oocytes. H-L. Ji, R. Molina, D.Han and R-Z. Zhao. Univ. of Texas Hlth. Sci. Ctr. at Tyler.D317 611.6 Biophysical features of a new cloned deltaENaC subunit. D. Han, H. Nie, R. Zhao, X. Su and H-L. Ji.Univ. of Texas Hlth. Sci. Ctr. at Tyler and China Med. Univ.,Shenyang.D318 611.7 Regulation of ENaC by 1,2-propanediol, di-2-ethylhexyl phthalate and texanol. D. Han, R. Molina, S. Idelland H-L. Ji. Univ. of Texas Hlth. Sci. Ctr. at Tyler.D319 611.8 Interaction of CMMD family proteins with theepithelial sodium channel. Y. Liu, M. Swart and F. McDonald.Univ. of Otago, New Zealand.D320 611.9 The molecular chaperones, ERdj3 and ERdj4,two Hsp40s, select ENaC for ER-associated degradation. C.R.Boyd, T.M. Buck, A.R. Kolb, T.R. Kleyman and J.L. Brodsky.Univ. of Pittsburgh.D321 611.10 Activation of the epithelial Na channel in thecollecting duct by vasopressin contributes to water reabsorption.V. Bugaj, O. Pochynyuk and J.D. Stockand. Univ. of TexasHlth. Sci. Ctr. at San Antonio.D322 611.11 Physiological regulation of ENaC in thealdosterone-sensitive distal nephron by a local endothelinsystem. V. Bugaj, O. Pochynyuk, D.E. Kohan and J.D.Stockand. Univ. of Texas Hlth. Sci. Ctr. at San Antonio andUniv. of Utah Hlth. Sci. Ctr.D323 611.12 Developmental changes in the ENaC channelof the chick chorioallantoic membrane. L.A. Gonzalez andD.U. Silverthorn. Univ of Texas at Austin.D324 611.13 Insulin stimulation of the epithelial sodiumchannel is inhibited by COMMD1. F.J. McDonald, M. Swartand Y. Ke. Univ. of Otago, New Zealand.D325 611.14 Functional expression of the epithelial sodiumchannel delta subunit in human respiratory epithelial cells. E.Schwagerus, S.T. Buckley and C. Ehrhardt. Sch. of Pharm.and Pharmaceut. Sci., Trinity Col. Dublin.D326 611.15 Renal epithelial Na channel protein expressionis reduced in H,K-ATPase knockout mice. M.M. Greenlee, I.J.Lynch, M.L. Gumz, B.D. Cain and C.S. Wingo. Univ. of Floridaand North Florida/South Georgia VA Med. Ctr.D327 611.16 Identification of epithelial Na + channel intersubunitCl - coordinating residues suggests a trimeric alpha,gamma, beta channel architecture. D.M. Collier and P.M.Snyder. Univ. of Iowa Carver Col. of Med.D328 611.17 Role of P97 protein in ENaC recycling. B.Malik, N.M. Mathur, Q. Yue, G. Yue, B.J. Duke, O. Al-Khaliliand D.C. Eaton. Emory Univ.D329 611.18 Phosphopeptide screen uncovers JNK1 asa potentiator of Nnedd4-2-mediated epithelial Na + channelinhibition. V. Bhalla, N.M. Oyster, M. Wijngaarden, J. Lee, H.Li, X. Xia, Z. Huang, R. Chalkley, A. Burlingame, D. Pearceand K. Hallows. Stanford Univ. Sch. of Med., Univ. of PittsburghSch. of Med., Leiden Univ. Med. Ctr., Netherlands and UCSF.physiologyD330 611.19 WNK4 inhibits ENaC activity and reducesg ENaC subunit expression, but has no effect on b ENaCexpression. L. Yu, H. Cai, B.J. Duke, A-K. Otor and D.C.Eaton. Emory Univ. Sch. of Med.D331 611.20 Epithelial sodium channel gating is modulatedby cysteine-palmitoylation. G.M. Mueller, A.B. Maarouf, C.L.Kinlough, N. Sheng, O.B. Kashlan, S. Luthy, S. Okumura,R.P. Hughey and T.R. Kleyman. Univ. of Pittsburgh Med. Ctr.D332 611.21 Mapping an inhibitory peptide binding site toconstruct a molecular model of the alpha subunit of the epithelialsodium channel. O.B. Kashlan, C.R. Boyd, C. Argyropoulos,S. Okumora, R.P. Hughey, M. Grabe and T.R. Kleyman. Univ.of Pittsburgh.D333 611.22 Regulation of ENaC by proprotein convertasesubtilisin/kexin type 9. V. Sharotri and P.M. Snyder. Univ. ofIowa Carver Col. of Med.D334 611.23 Mapping a limited inhibitory domain derivedfrom the gamma subunit of ENaC. C.J. Passero, M.D.Carattino, M.M. Myerburg, R.P. Hughey and T.R. Kleyman.Univ. of Pittsburgh.D335 611.24 Transition metals inhibit epithelial sodiumchannels via distinct mechanisms. S. Sheng, J. Chen and K.L.Winarski. Univ. of Pittsburgh.D336 611.25 An extracellular subdomain of the epithelial Na +channel gamma subunit confers Na + self-inhibition response.K.L. Winarski, N. Sheng, J. Chen, T.R. Kleyman and S.Sheng. Univ. of Pittsburgh.D337 611.26 Comparison of Na + regulation of exhaled breathcondensate and urine in healthy humans. C.M. Wheatley, N.A.Cassuto, W.T. Foxx-Lupo, E.C. Wong, A.E. Patanwala andE.M. Snyder. Univ. of Arizona.D338 611.27 An SP/TP motif in the N-terminal cytoplasmicdomain of UT-A3 as potential activation site of UT-A3-mediatedurea transport. A. Mistry, R. Mallick, J.D. Klein, J.M. Sandsand O. Fröhlich. Emory Univ.612. Airway and Alveolar Epithelial CellBiologyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD339 612.1 Bronchial epithelial dysfunction in asthma:similarities to metabolic syndrome. A. Agrawal, T. Ahmad, U.Mabalirajan, D.A. Joseph and B. Ghosh. Inst. of Genomicsand Integrat. Biol., Delhi.D340 612.2 Protease activated receptor-2 in the airwayepithelium: a sentinel receptor triggered by the asthmaassociated allergen Alternaria alternata. A.N. Flynn, J. Vagner,S. Schulz, J. Hoffman and S. Boitano. Univ. of Arizona.D341 612.3 Estrogen induces nitric oxide productionin human bronchial epithelial cells. E.A. Townsend, M.A.Thompson, S.D. Cassivi, C.M. Pabelick and Y.S. Prakash.Mayo Clin. Col. of Med.D342 612.4 Loss of cilia alters airway epithelial cells andevokes an immune response. S.K. Gilley, A.E. Stenbit, K.M.Sas, P.A. Flume and P.D. Bell. Med. Univ. of South Carolina.D343 612.5 Function of the HVCN1 proton channel inairway epithelia and a naturally occurring missense mutation,M91T. H. Fischer, D. Iovannisci, M. Hajighasemi and B. Illek.Children’s Hosp. Oakland Res. Inst.sun175

PhysiologyD344 612.6 Transepithelial ion transport properties ofhuman native small airways. A.K.M. Shamsuddin and P.M.Quinton. UCSD and Univ. of California, Riverside.D345 612.7 Homoserine lactone stimulates CFTRdependentCl - secretion in human airway epithelial cells: rolesfor Ca 2+ and cAMP. T.E. Machen, C. Schwarzer, S. Wong, J.Shi, E. Matthes, A. Hofer and B. Illek. Univ. of California,Berkeley, Harvard Univ., West Roxbury and Children’s Hosp.Oakland Res. Inst., CA.D346 612.8 Mechanisms of apical fluid volume control inairway epithelia. C.V. Falkenberg and E. Jakobsson. Univ. ofIllinois at Urbana-Champaign.D347 612.9 Functional expression of the hypoosmosensitivechannels TRPV4 and TRPM3 in mouse airwayepithelium. R. Lembrechts, I. Brouns, K. Schnorbusch, I.Pintelon, J-P. Timmermans and D. Adriaensen. Univ. ofAntwerp, Belgium.D348 612.10 Acute and selective activation of pulmonaryneuroepithelial bodies by mild hypo-osmotic stimuli. R.Lembrechts, I. Brouns, K. Schnorbusch, I. Pintelon, J-P.Timmermans and D. Adriaensen. Univ. of Antwerp, Belgium.D349 612.11 ATP promotes plasma membrane woundrepair by a P2Y2R dependent mechanism. H.A. Belete andR.D. Hubmayr. Mayo Clin.D350 612.12 Wound repair in type I alveolar epithelial cellsinvolves lysosome secretion followed by initiation of actinrepolymerization. L.M. Godin, J. Vergen, Y.S. Prakash andR.D. Hubmayr. Mayo Clin. and Creighton Univ.D351 612.13 HMGB1 accelerates alveolar epithelial repairvia an IL-1b-dependent activation of TGF-b1 by the avb6integrin. J. Roux, H. Koh, X. Fang, B.T. Houseman, K.M.Shokat, D. Sheppard, M.A. Matthay and J-F. Pittet. UCSFand Keio Univ., Japan.D352 612.14 ATF3 is activated in ventilator-induced lunginjury. C. Dos Santos, A. Akram, H. Masoom, B. Han, J.J.Haitsma, C. Peng, Y. Shan, H. Zhang, M. Liu, T. Hai and A.S.Slutsky. Univ. of Toronto, Ohio State Univ. and St. Michael’sHosp.,Toronto.D353 612.15 GABA receptors modulate ventilator-inducedlung injury. N.R. Chintagari and L. Liu. Oklahoma State Univ.D354 612.16 Heteropore characteristics of type I- and type IIlikerat alveolar epithelial cell monolayers. Y.H. Kim, Z. Borok,E.D. Crandall and K-J. Kim. Univ. of Southern California.D355 612.17 Mechanisms of zinc oxide nanoparticleinducedalveolar epithelial cell injury. Y.H. Kim, F. Fazlollahi,N.R. Yacobi, Z. Borok, K-J. Kim and E.D. Crandall. Univ. ofSouthern California.D356 612.18 Age-dependent changes in gene expressionprofiles of postnatally developing rat lungs exposed to nanosizeand micro-size CuO particles. M. Cormack, M. Lin, A.Fedulov, S.J. Mentzer and A. Tsuda. Harvard Sch. of Publ.Hlth. and Harvard Med. Sch.D357 612.19 Damage-associated molecular pattern markersare triggered by pulmonary nanotube exposure. B.L. Herndon,A. Patel, T. Quinn, E. Nalvarte-Kostoryz and E. Fibuch. Univ.of Missouri-Kansas City Sch. of Med., Sch. of Dent. and St.Luke’s Hosp.D358 612.20 Diesel particulate matter induces receptorfor advanced glycation end-products expression in alveolarepithelial cells and mediates an inflammatory response. K.M.Wasley, C.H. Allison and P.R. Reynolds. Brigham YoungUniv.sundayD359 612.21 RAGE and ERM proteins in EMT of humanalveolar epithelial cells. S.T. Buckley, C. Medina and C.Ehrhardt. Sch. of Pharm. and Pharmaceut. Sci., Trinity Col.Dublin.D360 612.22 HIV-1-related proteins decrease Nrf2expression and alter tight junction protein localization in theplasma membranes of cultured alveolar epithelial cells. X. Fan,P. Joshi, M. Koval and D.M. Guidot. Emory Univ. Sch. of Med.,VA Med. Ctr., Decatur.D361 612.23 Protein kinase activation is required forsecretagogue-stimulated membrane-association of fusionpromoting protein annexin A7 in alveolar type II cells. A.Chander, T. Gerelsaikhan, K. Holbrook and Y. Hayrapetyan.Stony Brook Univ. Med. Ctr.D362 612.24 Mitochondrial donation by mesenchymalstromal cells rescues alveolar surfactant secretion insepsis. M.N. Islam, K. Otsu, S.D. Houser, J. Lindert and J.Bhattacharya. Columbia Univ. Col. of P&S.D363 612.25 The PI 3-kinase/Akt pathway plays a role in thetrafficking of the surfactant protein-A receptor P63 (CKAP4) tothe cell surface of type II pneumocytes. S.R. Bates, J-Q. Tao,S.I. Feinstein, L. Zhang, A.B. Fisher and A.S. Kazi. Univ. ofPennsylvania Sch. of Med.D364 612.26 microRNA-150 regulates surfactant secretionvia P2X7 receptors. T. Weng, A. Mishra, Y. Guo, Y. Wang,L. Su and L. Liu. Oklahoma State Univ. and Univ. of TexasSouthwestern Med. Ctr.D365 612.27 Impact of untranslated regions (utrs) ondifferential translation among SftpA1 and SftpA2 gene variants.P. Silveyra, G. Wang and J. Floros. Penn State Col. of Med.613. Control of Breathing: DevelopmentPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD366 613.1 Age and sex differences in the hypercapnicventilatory response in awake neonatal rats. J.M. Wenninger,H.S. Holley and M. Behan. Sch. of Vet. Med., Univ. ofWisconsin-Madison.D367 613.2 Inspiratory neural network complexity ofunusual gasping patterns in urethane-anesthetized neonatalrats. L.D. Salay, I.M. Reid and I.C. Solomon. Stony BrookUniv.D368 613.3 Carotid body O 2sensitivity during chronichyperoxia and after recovery in normoxia. R.W. Bavis, N.Pradhan, N. Nawreen and D.F. Donnelly. Bates Col. and YaleUniv. Sch. of Med.D369 613.4 Neonatal maternal separation promotesrespiratory instability during heat exposure in 12-day-old rats:sex-specific role of o 2chemosensitivity. R. Kinkead and R.Gulemetova. Univ. Laval, Canada.D370 613.5 Ventilatory effect following 10 days concomitantexposure to neonatal intermittent hypoxia and neonatal caffeinetreatment in 12-day-old rats. C. Julien, V. Joseph and A.Bairam. Quebec Univ. Hosp. Ctr., Laval Univ.D371 613.6 Postnatal development of ATP signalinginvolved in respiratory response to hypoxia in rats. L. Niane,D.F. Donnelly, V. Joseph and A. Bairam. Quebec Univ. Hosp.Ctr., Laval Univ. and Yale Univ.176

sundayD372 613.7 Chronic ethanol exposure disruptsneuroventilation and responses to hypoxia in bullfrog tadpoles.L.H. McLane, C.M. Brundage and B.E. Taylor. Univ. of AlaskaFairbanks.D373 613.8 Insight on the development of neuroventilatoryGABA-mediated inhibition in bullfrog tadpoles. C.M. Cartagena,C.M. Brundage and B.E. Taylor. Univ. of Alaska Fairbanks.D374 613.9 Suppression of expiratory activity in a mousemodel of Rett syndrome follows blockade of GABA reuptakeand activation of serotonin type 1a receptors. A.P.L. Abdala,M. Dutschmann, J.M. Bissonnette and J.F.R. Paton. Univ. ofBristol, Univ. of Leeds and Oregon Hlth. & Sci. Univ.D375 613.10 Neonatal mice lacking serotonin neurons havehigh mortality that is worsened on exposure to hypoxia andhypercapnia. V.E. Cerpa, R. Flynn, R. Jamison and G.B.Richerson. Yale Univ. and VA Med. Ctr.D376 613.11 Chorioamnionitis decreases neonatalrespiratory pattern variability in transverse rat brainstem slices.C.A. Mayer, K.V. Balan, P. Kc, R.J. Martin and C.G. Wilson.Case Western Reserve Univ.D377 613.12 LPS-mediated inflammation alters neonatalcentral respiratory control. K.V. Balan, P. Kc, C.A. Mayer, C.G.Wilson, M.J. Miller and R.J. Martin. Case Western ReserveUniv.D378 613.13 Modulatory effect of fentanyl onbronchopulmonary C-fiber-mediated ventilatory responses isage-dependent in anesthetized rats. J. Zhuang, Z. Zhang, C.Zhang and F. Xu. Lovelace Resp. Res. Inst., Albuquerque.614. Control of Breathing: RhythmGenerationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD379 614.1 Effects of anesthetic state on properties of fastinspiratory rhythms in bilateral phrenic discharges of currarizedadult rats. M.I. Cohen, K. Ono and A.R. Granata. AlbertEinstein Col. of Med. and Chiba Univ., Japan.D380 614.2 New lentiviral vector to selectively targetglycinergic neurons in the brainstem. A.P.L. Abdala, B.H.Liu, I.A. Rybak, J.C. Smith and J.F.R. Paton. Univ. of Bristol,Drexel Univ. Col. of Med. and NINDS, NIH.D381 614.3 Role of GlyT 2expressing neurons in theBötzinger complex for respiratory rhythm and patterngeneration. A.P.L. Abdala, B.H. Liu, I.A. Rybak, J.C. Smithand J.F.R. Paton. Univ. of Bristol, Drexel Univ. Col. of Med. andNINDS, NIH.D382 614.4 Disturbed inspiratory rhythm in rat brainstemslices by seizure-like bursting due to theophylline-evokedGABA Areceptor block. B. Panaitescu, J. Kuribayashi, A.Ruangkittisakul and K. Ballanyi. Univ. of Alberta.D383 614.5 Multiphoton calcium imaging of methylxanthinereversalof opioid depression of inspiratory-related pre-Bötzinger complex rhythm in newborn rat brainstem slices.A. Ruangkittisakul, B. Panaitescu and K. Ballanyi. Univ. ofAlberta.physiologyD384 614.6 Effects of IV Remifentanil on the dischargepatterns of canine pre-Bötzinger complex neurons. S. Mustapic,T. Radocaj, A.G. Stucke, E.A. Stuth, Z. Dogas, F.A. Hoppand E.J. Zuperku. Med. Col. of Wisconsin, Children’s Hosp. ofWisconsin, Univ. of Split Sch. of Med., Croatia and Zablocki VAMed. Ctr., Milwaukee.D385 614.7 Dose-dependent depression of preB[ouml]tzinger complex region neurons by local application of the5HT1A receptor agonist 8OH-DPAT. T. Radocaj, S. Mustapic,A.G. Stucke, E.A. Stuth and E.J. Zuperku. Med. Col. ofWisconsin, Children’s Hosp. of Wisconsin and Zablocki VAMed. Ctr.D386 614.8 Localization of the amphibian respiratoryrhythm generator using a multilayer PDMS microfluidic chamber.M.S. Hedrick, M.J. Klingler, A.J. Blake, J.C. Williams andS.M. Johnson. California State Univ., East Bay and Univ. ofWisconsin-Madison.D387 614.9 Microfluidic chambers used to test whetherepisodic breathing is regulated by the pons in turtle brainstems.M.E. Bartman, A.R. Krisp and S.M. Johnson. Univ. ofWisconsin-Madison.D388 614.10 Respiratory rhythm and pattern after ibotenicacid injections into the pontine respiratory group of awakegoats. J. Bonis, S. Neumueller, K. Krause, T. Kiner, A. Smith,B. Marshall, Q. Baogang, L. Pan and H. Forster. Med. Col. ofWisconsin and VA Med. Ctr.615. Respiratory Responses to ExercisePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD389 615.1 Breathing efficiency in systolic heart failure:impact of hyperventilation and dead space. P.R. Woods, T.P.Olson, R.P. Frantz, K.A. O’Malley, M.L. Hulsebus and B.D.Johnson. Mayo Clin.D390 615.2 Gas bubble composition does not affect thedetection of exercise-induced intrapulmonary arteriovenousshunt in hypoxia, normoxia or hyperoxia. J.E. Elliott, Y. Choi,S.S. Laurie, X. Yang, I.M. Gladstone and A.T. Lovering. Univ.of Oregon, Univ. of Puget Sound and Oregon Hlth. & Sci. Univ.D391 615.3 Exercise-induced flow limitation in adults witha history of bronchopulmonary dysplasia. A.T. Lovering, X.Yang, S.S. Laurie, J.E. Elliott, K.M. Beasley, J.A. Hawn andI.M. Gladstone. Univ. of Oregon, Oregon Heart & Vasc. Inst.,Springfield and Oregon Hlth. & Sci. Univ.D392 615.4 Oxygen uptake efficiency duringcardiopulmonary exercise testing in healthy subjects. X. Sunand J.E. Hansen. LA BioMed Res. Inst. at Harbor-UCLA Med.Ctr.D393 615.5 Oxygen uptake efficiency plateau duringcardiopulmonary exercise testing is best predictor of earlydeath in heart failure patients. X. Sun and J.E. Hansen. LABioMed Res. Inst., Torrance.D394 615.6 Regulation of arterial H + during exercise in man.K. Wasserman, X-G. Sun, W.W. Stringer and W.L. Beaver. LABioMed Res. Inst. at Harbor-UCLA Med. Ctr.sun177

Physiologysunday616. Gravitational and SpacePosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD395 616.1 Cardiovascular responses to standing andwalking in Earth and simulated Moon and Mars gravities. J.M.Evans, P.J. Kilfoil, S. Wang, L. Mohney and C.F. Knapp. Univ.of Kentucky.D396 616.2 Orthostatic tolerance and breast highcompression garments. J.M. Evans, R.S. Schneider, S.H.Platts, A.K. Brown, M.B. Stenger and C.F. Knapp. Univ. ofKentucky, NASA Johnson Space Ctr., MEI Technol., Houstonand Wyle Integrated Sci. and Engin. Gp., Houston.D397 616.3 A questionable association of stroke volumeand arterial pulse pressure under gravitational stress. A.T.Cote, S.S.D. Bredin and D.E.R. Warburton. Univ. of BritishColumbia.D398 616.4 ES-1 BREP: Chinese herb and vibrationcombined with resistance exercise countermeasures mainleg venous vascular characteristics during 60d head-downbed rest. Y. Ming, M-A. Custaud, L. Yinghui, P. Arbeille, B.Yanqiang, M. Coupe and J. Shizhong. Astronaut Sci. Res.Trng. Ctr. of China, Beijing, Univ. d’Angers Fac. of Med. andUMPS Med. Physiol. spatiale, Tours, France.D399 616.5 Is there diurnal variation with thevestibulosympathetic reflex? J.S. Cook, S.A. Chin-Sang, C.L.Sauder and C.A. Ray. Penn State Col. of Med.D400 616.6 The effect of simulated 1/6th and 1/3rd gravityon gastrocnemius muscle mass and fractional protein synthesisrates in mice. M.P. Wiggs, J.M. Swift, F. Lima, E.S. Greene,S.A. Bloomfield and J.D. Fluckey. Texas A&M Univ.D401 616.7 Weightbearing in simulated 1/6th and 1/3rdgravity does not prevent cancellous bone loss. B.R. Macias,J.M. Swift, F. Lima, E.S. Greene, M.R. Allen and S.A.Bloomfield. Texas A&M Univ. and Indiana Univ., Indianapolis.D402 616.8 Simulated microgravity-induced changes inskeletal bones as measured by X-ray using 20 keV electronbeam. R. Mehta, A.M. Watson, N. Ali, M. Soulsby and P.Chowdhury. Univ. of Central Arkansas, Univ. of Arkansas atLittle Rock and Univ. of Arkansas for Med. Sci.D403 616.9 An alternant method to the traditional NASAhindlimb suspension model in mice. J.A. Ferreira, J.M. Crisseyand M. Brown. Univ. of Missouri-Columbia.D404 616.10 Reconsideration of exercise prescription as thecountermeasure for prevention of muscle atrophy in space. T.Ohira, H. Okabe, F. Kawano, Y. Oke, R. Fujita, S. Nomura,N. Nakai, T. Ohira, K. Ohira and Y. Ohira. Osaka Univ.,Kokushikan Univ. and Tottori Univ., Japan.D405 616.11 Effect of antigravity muscle activity on learningcapacity and hippocampal protein expression in juvenile rats. Y.Oke, F. Kawano, S. Nomura, T. Ohira, R. Fujita, N. Nakai andY. Ohira. Grad. Sch. of Med. and Grad. Sch. of Frontier Biosci.,Osaka Univ.D406 616.12 Leptin and ghrelin levels in humans to physicalinactivity induced by simulated microgravity. D. Kanikowska,M. Sato, S. Iwase, N. Nishimura, Y. Shimizu, Y. Inukai and J.Sugenoya. Aichi Med. Univ., Japan.617. History of PhysiologyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD407 617.1 The University of California at Santa BarbaraInstitute of Environmental Stress marathon field studies of1973-75. M.B. Maron. Northeastern Ohio Univs. Col. of Med.and Univ. of New England Osteo. Sch. of Med.D408 617.2 Peer review and oversight of aero medicalresearch during World War II in America: the Committee onAviation Medicine and its subcommittees. J.B. Dean. Univ. ofSouth Florida.D409 617.3 Denitrogenation (preoxygenation) as aprophylactic treatment for flier’s bends during high altitudemissions in unpressurized aircraft of the Allied Air Forces inWorld War II. J.B. Dean. Univ. of South Florida.618. Exercise Responses and Training IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD410 618.1 Idiosyncratic control of the center of massin expert climbers. M.L. Zampagni, S. Brigadoi and Y.P.Ivanenko. Sci. Inst. Fndn. Santa Lucia, Rome, Trento Univ. andPadova Univ.D411 618.2 Are international guidelines for physical activitysufficient to improve health status? H.J.A. Foulds, S.S.D.Bredin, S.A. Charlesworth, A.C. Ivey and D.E.R. Warburton.Univ. of British Columbia.D412 618.3 The influence of physical exertion on rapiddecision making in athletes versus non-athletes. R.S. Orf,K. Wickenhauser, J. Warncke, T. Miller and A. Potterfield.Westminster Col., MO.D413 618.4 The effects of expiratory muscle strengthtraining in elite college swimmers. V. Bernhardt, S.M. Nedrud,G. Troy and P.W. Davenport. Univ. of Florida and Univ. AthleticAssn., Gainesville.D414 618.5 Dietary choline affects strength gains in elderlypeople. C.W. Lee, T.V. Lee, V.C.W. Chen, S. Bui and S.E.Riechman. Texas A&M Univ.D415 618.6 Effect of walking exercise types on bodycomposition and eating inhibition and facilitation hormone.C.I. Na, D. Kim, H. Lee, H. Kim, J. Jung, H. Kim, M. Yang, S.Kwon, W. Jung, H. Moon, C. Baek and D. Kim. Chonnam Natl.Univ., Republic of Korea and Univ. of Oklahoma.D416 618.7 Effect of hand-weight walking on bodycomposition, lipoprotein metabolism and obesity hormone ofthe obese middle-school girls. C.I. Na, D. Kim, H. Lee, E. Shim,J. Jung, H. Kim, M. Yang, S. Kwon, W. Jung, H. Moon, C.Baek and D. Kim. Chonnam Natl. Univ., Republic of Korea andUniv. of Oklahoma.D417 618.8 The effects of creatine and exercise on skeletalmuscle of FRG1-transgenic mice. D.I. Ogborn, A. Safdar,B.P. Hettinga, J.D. Crane, R. Tupler and M.A. Tarnopolsky.McMaster Univ., Canada and Univ. of Massachusetts Med.Sch.178

sundayD418 618.9 Does supplemental creatine decreaserehabilitation time in young adults with immobilization relatedinjuries? M.A. Corn, D. Kallail, C. Bullock, D. Payne and E.Raynes. Tennessee State Univ., Spring Hill, Nashville, Antiochand Brentwood.D419 618.10 Effect of high intensity interval training onsubstrate utilization. D.W. Roberson, T.A. Astorino, R.P.Allen, E. Trost and M. Jurancich. California State Univ., SanMarcos.D420 618.11 20-week resistance training in 70-year-oldsimproves glucose handling and leg blood flow responsivenessto feeding and exercise-plus-feeding without reversing agerelateddeclines in protein kinase B responses or increasingendothelial markers. B. Phillips, W. Hildebrandt, J. Williams,P.J. Atherton, D. Rankin, K. Smith, I. Macdonald, P. Greenhaffand M. Rennie. Univ. of Nottingham.D421 618.12 A prior bout of contractions speeds oxygenuptake and blood flow on kinetics and reduces the slowcomponent of oxygen uptake in highly oxidative skeletal muscle.A. Hernández, J.R. McDonald, N. Lai and L.B. Gladden.Auburn Univ. and Case Western Reserve Univ.D422 618.13 Impact of chronic intermittent forearmcompressions on blood flow capacity in humans. B.T.Roseguini, R. Sheldon, A. Stroup, J.W. Bell, I. Skarbek, D.Maurer, M.H. Laughlin and S.C. Newcomer. Univ. of Missouri-Columbia and Purdue Univ.D423 618.14 Exercise training improves the metabolicphenotype of pre- and postnatal growth restricted male ratoffspring. R.C. Laker, M.E. Wlodek, G.D. Wadley and G.K.McConell. Univ. of Melbourne.D424 618.15 Treatment with swimming and treadmillexercises reduced neuropathic pain on chronic constrictioninjury of sciatic nerve of rats. Y.T. Li, Z.Y. Li, M.I. Hsueh, H.C.Hung, H-C. Ou and Y.W. Chen. China Med. Univ., Taiwan.D425 618.16 Exercise training in two-kidney, one-clip ratsdecreases blood pressure via predominantly nitric oxidemechanisms in paraventricular nucleus. N.F. Rossi and M.Maliszewska-Scislo. Wayne State Univ. and John D. DingellVA Med. Ctr.D426 618.17 Diet and exercise training reverses the vascularreactivity impairment of subjects with the 894G>T endothelialnitric oxide synthase gene polymorphism. B.M. Silva, F.J.Neves, A.K. Sales, N.G. Rocha, R.F. Medeiros, T.C. Barbosa,F.S. Pereira, F.T. Cardoso and A.C.L. Nóbrega. Rio de JaneiroState Univ. and Fluminense Fed. Univ., Brazil.D427 618.18 Endurance exercise training increasesmedullary and extramedullary hematopoiesis. J. Baker, M. DeLisio and G. Parise. McMaster Univ., Canada.D428 618.19 Endurance training attenuates loss of bonestrength in the polymerase gamma mutator mouse model ofaging. A. Antolic, A. Safdar, J.M. Bourgeois, B.P. Hettinga,G.R. Wohl, G.C. Kujoth, T.A. Prolla and M.A. Tarnopolsky.McMaster, Canada and Univ. of Wisconsin-Madison.D429 618.20 Equivalent increases in bone mineral densitydespite differences in training volume in growing rats. S.M.Shdo, R.M. Cunningham, R.A. Pierce, L.C. Lee, C.P. Ahles,S.V. Jaque and K.D. Sumida. Chapman Univ. and CaliforniaState Univ., Northridge.D430 618.21 Mouse strain dependent variation in exercisecapacity. S.M. Courtney and M.P. Massett. Texas A&M Univ.physiologyD431 618.22 Cortisol level and behavioral response toexercise in dogs kenneled in a humane society: model forstress relief. C. Belpedio, L. Buffington, S. Clusman, F. Prete,A. Sadler, L. Whittemore and S. Mungre. Northeastern IllinoisUniv., Dog Days Training Inc., Berthoud, CO and LongmontHumane Soc., CO.D432 618.23 IL-6 and delayed onset muscle soreness do notvary during the menstrual cycle. M.E. Chaffin, K.E. Berg, J.R.Meendering, T.L. Trehearn, J.A. French and J.E. Davis. Univ.of Nebraska at Omaha, Southern Illinois Univ., South DakotaState Univ. and Univ. of Nebraska Med. Ctr.D433 618.24 Cortisol response to an acute bout of staticstretching. S.E. Fuller and L.K. Stewart. LSU.D434 618.25 Effect of the Pilates exercise on the healthphysical fitness, immunoglobulin and sex hormone in femalecollege students. C.I. Na, D. Kim, H. Lee, H. Jung, J. Jung,H. Kim, M. Yang, S. Kwon, W. Jung, H. Moon, C. Baek andD. Kim. Chonnam Natl. Univ., Republic of Korea and Univ. ofOklahoma.D435 618.26 Maternal heart rate and heart rate variabilityduring pregnancy and exercise training. C. Paynter, C.Meacham, C. Ramar, K.M. Gustafson, R.R. Suminski andL.E. May. Kansas City Univ. of Med. and Biosci., MO and Univ.of Kansas Med. Ctr.D436 618.27 The consequences of maternal training anddetraining in adult offspring. L. Fernandes, B.F.A. Calegare,S. Tufik and V. D’Almeida. UNIFESP, São Paulo.619. Cardiovascular Responses to Exercise IPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD437 619.1 p22 phox Inhibition in skeletal muscle normalizesthe exaggerated exercise pressor reflex in chronic heart failure.H. Wang, L. Gao, M.C. Zimmerman, I.H. Zucker and W. Wang.Univ. of Nebraska Med. Ctr.D438 619.2 Skeletal muscle metaboreflex overactivity ispartially corrected by decreasing superoxide within the nucleustractus solitarius of hypertensive rats. M.N. Murphy, M. Mizunoand S.A. Smith. Univ. of Texas Southwestern Med. Ctr.D439 619.3 The pressor response mediated by group IIImuscle afferent mechanoreflex is altered in prehypertensivewomen. S-A. Park, K-A. Kim, H-M. Choi, S. Park, J-H. Lee,J-M. Chun, H. Nho and J-K. Kim. Kyung Hee Univ., Republicof Korea.D440 619.4 Activation of peripheral mu-opioid receptorattenuates the augmented exercise pressor reflex seen in ratswith chronic femoral artery occlusion. H. Tsuchimochi, J.L.McCord and M.P. Kaufman. Penn State Heart & Vasc. Inst.,Hershey.D441 619.5 The sympathetic response to activation of theskeletal muscle mechanoreflex is enhanced in spontaneouslyhypertensive rats. M. Mizuno, M.N. Murphy, J.H. Mitchell andS.A. Smith. Univ. of Texas Southwestern Med. Ctr.D442 619.6 Sex-specific effects of atorvastatin on theblood pressure response to exercise. E.G. Dostaler, P.D.Thompson, R.S. Axtell, P. Latchman and B.A. Parker.Southern Connecticut State Univ. and Hartford Hosp.sun179

PhysiologyD443 619.7 The influence of the intensity of a single boutof aerobic exercise on endothelial function in obese postmenopausalwomen. D.J. Cheek, K. Boyd and J. Mitchell.Harris Col. of Nursing and Hlth. Sci., Texas Christian Univ.D444 619.8 Cardiovascular responses to dynamic exercisein postmenopausal women. K-A. Kim, S-A. Park, H-M. Choi,S. Park, J-H. Lee, J-M. Chun, H. Nho and J-K. Kim. KyungHee Univ., Republic of Korea.D445 619.9 Short-term AMPK activation improves vascularendothelial function in old mice by a different mechanism thanhabitual aerobic exercise. B.R. Lawson, D.R. Seals, K.A.Magerko, J.R. Durrant, M.L. Zigler, A.J. Donato and L.A.Lesniewski. Univ. of Colorado at Boulder.D446 619.10 Aging induced alterations in carotid baroreflexcontrol of arterial blood pressure at rest and during dynamicexercise in humans. J.P. Fisher, A. Kim, C.N. Young andP.J. Fadel. Univ. of Birmingham, U.K. and Univ. of Missouri-Columbia.D447 619.11 Impaired hypoxic exercise vasodilation inolder adults. T.D. Evans, G. Blain, J. Limberg, A. Kiefer, J.Sebranek, L. Proctor and W. Schrage. Univ. of Wisconsin-Madison.D448 619.12 Comparison baroreflex between male andfemale rats: role of exercise training. H. Machert, M. Sartori,I.C. Sanches, L. Jorge, D.S. Dias, C. Mostarda, M.C. Irigoyenand K. De Angelis. São Judas Tadeu Univ., Brazil and Univ. ofSão Paulo.D449 619.13 Effect of short-term training on markers ofinflammation in a swine model of atherosclerosis. I. Masseauand D.K. Bowles. Univ. of Missouri-Columbia.D450 619.14 Aerobic interval training attenuates pathologicalcardiovascular remodeling in aortic-banded miniature swine.C.A. Emter, C.P. Baines and D.K. Bowles. Univ. of Missouri-Columbia.D451 619.15 Diverse effects of exercise on myofilamentfunction in pathologic left ventricular hypertrophy anddysfunction. E.D. van Deel, M. de Boer, N.M. Boontje, M. deWaard, J. van der Velden and D.J. Duncker. Erasmus Med.Ctr., Univ. Med. Ctr. Rotterdam, Netherlands and VU Univ. Med.Ctr., Amsterdam.D452 619.16 Exercise and endogenous antioxidant enzymeactivity in perfused and ischemic cardiac tissue. J.C. Quindry,L.E. Schreiber, G.R. McGinnis, J.M. Irwin, M. Landram, Z.Urbiztondo and L. Allums. Auburn Univ. and AppalachianState Univ.D453 619.17 Endurance exercise rescues cardiomyopathyin mitochondrial DNA mutator mouse model of aging. A.Safdar, D.I. Ogborn, J.M. Bourgeois, S. Melov, A. Hubbard,B.P. Hettinga, G.C. Kujoth, T.A. Prolla and M.A. Tarnopolsky.McMaster Univ., Canada, Buck Inst. for Age Res., Novato, CAand Univ. of Wisconsin-Madison.D454 619.18 Early exercise training attenuates left ventriculardysfunction, myocardial infarction area and molecularabnormalities in diabetic rats. B. Rodrigues, L. Jorge, C.Malfitano, A. Medeiros, K.T. Rosa, T.C. Alba-Loureiro, G.O.Candido, R. Curi, S. Lacchini, P.C. Brum, K. De Angelis andM.C. Irigoyen. Heart Inst., Sch. of Phys. Educ. and Sports andInst. of Biomed. Sci., Univ. of São Paulo and São Judas TadeuUniv., Brazil.D455 619.19 Effect of exercise-training on EDHF-mediatedrelaxation after chronic coronary occlusion. R.R. Boyle, M.D.Smith and C.L. Heaps. Texas A&M Univ.sundayD456 619.20 Endurance exercise protects cardiac tissuefrom doxorubicin-induced proteolysis and apoptosis. A.N.Kavazis, A.J. Smuder, K. Min, N. Tümer and S.K. Powers.Univ. of Florida and VA Med. Ctr.D457 619.21 Exercise training restores contractility incollateral-dependent myocardium independent of calciumsensitization of myofilament proteins. V. Sarin, X. Wu, M.Muthuchamy and C.L. Heaps.620. Signal Transduction and ModulationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD458 620.1 Annexin A1 mediates the effects ofdexamethasone on macula densa cyclooxygenase-2expression. S. Seidel, T. Roeschel, T. Kahl, J. Schnermann,S. Bachmann and A. Paliege. Charité, Berlin and NIDDK,NIH.D459 620.2 Regulation of annexin A1 in the maculadensa: association with neuronal nitric oxide synthase andcyclooxygenase-2. A. Paliege, S. Seidel, T. Roschel, K. Mutigand S. Bachmann. Charité, Berlin.D460 620.3 Endothelin-1 induces serine 910phosphorylation of focal adhesion kinase via PKCdelta-andSrc-dependent signaling pathways. M. Chu, R. Iyengar, Y.Koshman, T. Kim and A.M. Samarel. Loyola Univ. Med. Ctr.D461 620.4 Interaction of tricyclic antidepressants withthe ha3b4 nicotinic receptor. A.H. Ahmad, D. Feuerbach, K.Jozwiak and H.R. Arias. Midwestern Univ., AZ, Novartis Insts.for Biomed. Res. and Med. Univ. of Lublin.D462 620.5 Structure-function correlation of G6, a novelsmall molecule inhibitor of Jak2: indispensability of thestilbenoid core. A. Majumder, L. Govindasamy, A. Magis,R. Kiss, T. Polgar, R.W. Allan, M. Agbandje-McKenna, G.M.Keseru, K. Bisht and P.P. Sayeski. Univ. of Florida.D463 620.6 PI3K and MAPK activation during eccentriccardiac hypertrophy. A. Zhao, Z. Alvin, V. Cousins and G.E.Haddad. Howard Univ.D464 620.7 NF449 is a novel inhibitor of fibroblast growthfactor receptor 3 signaling active in chondrocytes and multiplemyeloma cells. K. Chlebova and P. Krejci. Masaryk Univ.,Czech Republic.D465 620.8 Maturation and differential role of PKC isoformsin adrenergic, serotonergic, and phorbol ester–mediatedcerebral artery contractility. N. Chu, R. Goyal, D. Goyal andL.D. Longo. Loma Linda Univ.D466 620.9 Selective downregulation of human Kv1.3channels by PKA I. Z. Kuras, V. Kucher, L. Neumeier, K.Dillehay and L. Conforti. Univ. of Cincinnati.180

sunday621. Aging and Muscle FunctionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD467 621.1 Caloric restriction attenuates many agerelatedchanges in skeletal muscle mitochondrial physiology.I.R. Lanza, E. Li, D. Jakaitis, B. Ali and K.S. Nair. Mayo Clin.Col. of Med.D468 621.2 The effects of aging on muscle loss and NFkBlevels of various tissues in rats. T.C. LaGuire, C.R. Kohlenand S.K. Reaves. California Polytech State Univ., San LuisObispo.D469 621.3 MIP/MTMR14 is implicated in skeletal muscleaging. L. Brotto, R. Craig, T. Hall, M. Loghry, H. Valdivia, T.Nosek, J. Shen, C-K. Qu and M. Brotto. Univ. of Missouri-Kansas City Schs. of Nursing and Med., Univ. of Wisconsin-Madison Sch. of Med. and Case Western Reserve Univ. Sch. ofMed.D470 621.4 Effects of b-hydroxy-b-methylbutyrate onmuscle IGF-I and MGF mRNA expression in aged female ratsduring 10-week resistance training. Y-M. Park, S-R. Lee, J.M.Wilson, P.C. Henning, C. Ugrinowitsch, M.C. Zourdos, B.H.Arjmandi, J.A. Rathmacher and J-S. Kim. Florida State Univ.and Iowa State Univ.622. Cardiac Muscle PhysiologyPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD471 622.1 A session of strength exercise induced cardiachypertrophy by AT1 receptor-AKT-mTOR signaling pathway.S.F.S. Melo, M.A. Amadeu, T. Fernandes, E.C. Carmo, F.C.Magalhães, D.L.M. Barreti, U.P.R. Socci, C.R. Alves, F.R.R.Redondo, P.C. Brum and E.M. Oliveira. Univ. of São Paulo.D472 622.2 Mitochondrial uncouplers trigger ventricularfibrillation in isolated rat hearts. H. Clements-Jewery. WestVirginia Sch. of Osteo. Med.D473 622.3 Clofibric acid has positive inotropic effectson cardiac muscle. S-H. Kim, O.M. Mirza, J.K. Stone, C.D.Touchberry, J. Youssef, M.Z. Badr and M.J. Wacker. Univ. ofMissouri-Kansas City.D474 622.4 Thyroid hormone increases rapidly the lengthof the AT1R mRNA poly-A tail in cardiomyocytes. G.P. Diniz, E.Bruneto, F. Goulart da Silva, M.T. Nunes and M.L.M. Barretode Chaves. Univ. of São Paulo.D475 622.5 AMPK signaling pathway is downregulated bythyroid hormone in cardiomyocytes. A.P.C. Takano, G.P. Dinizand M.L. Barreto-Chaves. Univ. of São Paulo.D476 622.6 Impact of dietary fish oil on the atrial endothelinsystem and inositol triphosphate signaling: relevance topostoperative atrial fibrillation. F. Mayyas, S. Sakurai, M.Niebauer, M.K. Chung and D.R. Van Wagoner. ClevelandClin.D477 622.7 Cardiac enlargement during pregnancy mayinvolve new myocyte formation. S. Foster, C. Miller, A. Bilko,A. Injaian and B.A. Bailey. Ursinus Col. and Temple Univ. Sch.of Med.623. Central Autonomic RegulationPosterphysiologySu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD478 623.1 Interaction of GABA and glutamate inputsin the dorsal motor nucleus of the vagus. T. Babic, K.N.Browning and R.A. Travagli. Pennington Biomed. Res. Ctr.,Baton Rouge.D479 623.2 The central oxytocin system mediates theactions of nesfatin-1. G.L.C. Yosten and W.K. Samson.D480 623.3 Functional brainstem expression of T-typecalcium channel subunit alpha1H but not alpha1G maintainingsympathetic tone generation in neonatal B6 mice. C-K. Su,Y-P. Fan and C-C. Chen. Inst. of Biomed. Sci., Acad. Sinica,Taipei.D481 623.4 Resting arterial blood pressure (ABP),sympathetic control of resting ABP, and hypertensive responsesto 7-days of intermittent hypoxia are similar in rats bred for lowand high aerobic capacity running. A.L. Sharpe, M.A. Andrade,M. Herrera-Rosales, A. Calderon, S.L. Britton, L.G. Kochand G.M. Toney. Univ. of Texas Hlth. Sci. Ctr. at San Antonioand Univ. of Michigan Med. Sch.D482 623.5 Pancreatic preganglionic neurons: differentialresponses to CCK 1and 5-HT 3receptor stimulation. A.J.M.Verberne, B.M. Mussa and D.M. Sartor. Univ. of Melbourne.D483 623.6 An initial transient is followed by steady-stateregulation of blood pressure during hibernation bouts in theSyrian hamster. C.E. Song, H. Pham, J.S. Hamilton, J.M.Horowitz, B.A. Horwitz and C-Y. Chen. Univ. of California,Davis.D484 623.7 Physical training restores the increasedpressor and chronotropic responses intensity-induced byacute exercise in rats fed with hypercaloric diet. D.C. Lima, J.B.Guimarães, G.V. Rodovalho, S.A. Silveira, A.S. Haibara andC.C. Coimbra. Fed. Univ. of Minas Gerais and Fed. Univ. ofAlfenas, Brazil.D485 623.8 Heart rate control, but not the ventilatoryresponse to CO 2, is altered in 5HT 1Areceptor knockout miceduring early development: possible relevance for sudden infantdeath syndrome. K. Barrett, A. Daubenspeck, A. Li and E.Nattie. Dartmouth Med. Sch.D486 623.9 Age-dependent failure of cardiac autoresuscitationin neonatal Pet-1 -/- mice exposed to multiple boutsof anoxia: implications for the sudden infant death syndrome.K.J. Cummings, A. Li and E. Nattie. Dartmouth Med. Sch.D487 623.10 Stimulation of the efferent vagus nervemitigates acute lung injury and ventilator-induced lung injury.C. Dos Santos, Y. Shan, A. Akram, C. Peng, A.S. Slutsky andJ. Haitsma. Univ. of Toronto and St. Michael’s Hosp.D488 623.11 Increases in N-type calcium current augmenttransmitter release following three days of chronic intermittenthypoxia. D.L. Kunze, A. Ramirez-Navarro and D.D. Kline.Case Western Reserve Univ., MetroHlth. Med. Ctr. and Univ. ofMissouri-Columbia.D489 623.12 Respiratory responses to NaHS are mediatedby central mechanisms. J. Yu, H. Li, Y. He and J. Walker. Univ.of Louisville.D490 623.13 Effects of isoflurane anesthesia on murineglucose metabolism. C. Constantinides, R. Mean, B. Janssenand L.W. Hedlund. Univ. of Cyprus, Cardiovasc. Res. Inst.Maastricht, Netherlands and Duke Univ. Med. Ctr.sun181

PhysiologyD491 623.14 Distribution and morphology ofcatecholaminergic and cholinergic axons in whole-mountmouse atria. S.W. Harden and Z. Cheng. Col. of Med., Univ. ofCentral Florida.D492 623.15 Decrease in cardiovascular stress reactivity inAT 1Areceptor knockout mice is stimulus intensity-dependent. D.Mayorov, C.A. Chavez and K.H. Choy. Univ. of Melbourne.624. Neural Control and AutonomicRegulation: Nucleus TractusSolitariusPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD493 624.1 Temperature dependence of signal processingin nucleus tractus solitarius 2nd-order neurons in Syrianhamsters. S-i. Sekizawa, J.M. Horowitz, B.A. Horwitz andC-Y. Chen. Univ. of California, Davis.D494 624.2 Oxytocin-immunoreactive axons closelyappose tyrosine hydroxylase-immunoreactive neurons in therat nucleus of the solitary tract and dorsal vagal motor neuronsthat supply the gastrointestinal tract. I.J. Llewellyn-Smith, R.A.Travagli and K.N. Browning. Flinders Univ., Australia andPennington Biomed. Res. Ctr., Baton Rouge.D495 624.3 Responses of nucleus tractus solitariusneurons to vanilloid, purinergic and CCK receptor activation.K.N. Browning and R.A. Travagli. Pennington Biomed. Res.Ctr., Baton Rouge.D496 624.4 GABA Breceptors depress glutamate releaseat C-fiber afferent synapses in the nucleus of the solitary tract.J.A. Fawley, J.H. Peters, S.J. McDougall and M.C. Andresen.Oregon Hlth. & Sci. Univ.D497 624.5 Effects of chronic blockade of cannabinoid 1receptors in the NTS on blood pressure in Sprague Dawleyrats. F.A. Hopp, C. Dean, C.J. Hillard and J.L. Seagard. Med.Col. of Wisconsin and Zablocki VA Med. Ctr.D498 624.6 Mechanisms mediating heart rate responsesevoked by activation of NTS A 1adenosine receptors. J.M.McClure, Z. Minic, C. Li, D.S. O’Leary and T.J. Scislo. WayneState Univ. Sch. of Med.D499 624.7 Modulation of baroreflex sensitivity byendogenous angiotensins in lamb solitary tract nucleus. H.A.Shaltout, J.C. Rose, M.C. Chappell and D.I. Diz. Wake ForestUniv. Sch. of Med.D500 624.8 Aging is associated with resistance to thecardiovascular actions of leptin for baroreflex modulation. A.C.Arnold and D.I. Diz. Wake Forest Univ. Sch. of Med.D501 624.9 Contributions of hydrogen sulfide to synapticneurotransmission in the nucleus of the solitary tract in normoxiaand following chronic intermittent hypoxia. J.R. Austgen, H.A.Dantzler and D.D. Kline. Univ. of Missouri-Columbia.D502 624.10 Glutamatergic transmission is altered in thecaudal NTS of rats submitted to chronic intermittent hypoxia.J.H. da Costa Silva, D.B. Zoccal and B.H. Machado. Sch. ofMed. of Ribeirão Preto, Univ. of São Paulo.D503 624.11 Activation of NTS A 2aadenosine receptorsimpairs cardiopulmonary chemoreflex control of renal, adrenaland lumbar sympathetic nerve activity. Z. Minic, D.S. O’Learyand T.J. Scislo. Wayne State Univ. Sch. of Med.sundayD504 624.12 Structural integration and cardiovasculareffects following transplantation of endothelial progenitor cellsinto the brainstem of rats. A.M. Alviar Baquero, N. Kränkel, J.Whitaker, M. Dewhurst, P. Maddedu and J.F.R. Paton. Univ.of Bristol and Pfizer, Sandwich, UK.D505 624.13 Functional effects of endogenous BDNF in thenucleus tractus solitarius. C.G. Clark, D.D. Kline, D.L. Kunze,D.M. Katz and E.M. Hasser. Univ. of Missouri-Columbia,Rammelkamp Ctr., MetroHlth. Systs. and Case WesternReserve Univ.D506 624.14 Cardiovascular responses to ATP into thenucleus of the solitary tract in AV3V-lesioned rats. P.M. DePaula, D.C. Zanella, A.C. Takakura, E. Colombari and J.V.Menani. Sch. of Dent.-UNESP, Araraquara, Brazil.D507 624.15 Expression of c-Fos protein in the nucleus oftractus solitary and paraventricular nucleus of the hypothalamuselicited by electrical stimulation of the aortic depressor nerve inconscious L-NAME-induced hypertensive rats. R.M. Pereira,M.T. Durand, J.A. Castania, M. Oliveira, M.C.O. Salgado, R.Fazan, Jr. and H.C. Salgado. Sch. of Med. of Ribeirão Preto,Univ. of São Paulo.625. Neural Control of CardiovascularFunctionPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD508 625.1 ASIC2 dependent activation of thebaroreceptors is required for the arterial baroreflex. R.Sabharwal, D. Morgan, C.A. Whiteis, K. Rahmouni, M.W.Chapleau and F.M. Abboud. Univ. of Iowa and VA Med. Ctr.D509 625.2 ASIC3 in dorsal root ganglion neuronscontributes to femoral occlusion-enhanced sympatheticresponsiveness. J. Liu, J. Xing, Z. Gao and J. Li. Penn StateCol. of Med.D510 625.3 Activity of neurons in the rostral ventrolateralmedulla of conscious cats. S.M. Barman, L.A. Cotter, V.J.DeStefino, D.A. Reighard and B.J. Yates. Michigan StateUniv. and Univ. of Pittsburgh.D511 625.4 Central Ang-(1-7) enhances baroreflex gain inrabbits with chronic heart failure. S. Kar, P.L. Curry and I.H.Zucker. Univ. of Nebraska Med. Ctr.D512 625.5 Mas and AT1 receptor expression in adultsheep dorsomedial medulla. A. Arter, M. Nautiyal, H.A.Shaltout, M.C. Chappell and D.I. Diz. Wake Forest Univ.D513 625.6 Peripheral activation of ACE2-Ang-(1-7)-Masaxis reduces the cardiovascular reactivity to acute stress inrats. A.M. Lima, C.H. Xavier, R.A.S. Santos, M.K. Raizada,A.J. Ferreira and M.A.P. Fontes. Fed. Univ. of Minas Gerais,Brazil and Univ. of Florida.D514 625.7 AT 1Areceptor deficiency attenuatescardiovascular reactivity to contextual fear conditioning but notanxiety-like behavior in mice. D. Mayorov, K.H. Choy and C.A.Chavez. Univ. of Melbourne.D515 625.8 A novel algorithm for quantifying multiunitsympathetic nerve activity. M. Brockway, P.A. Guzman, B.Veitenheimer, M. Kuroki and J.W. Osborn. Univ. of Minnesota,Minneapolis.182

sundayD516 625.9 A comparison of two radiotelemetry transmittersfor the recording of behavioral and electrocardiographic data inprairie voles (Microtus ochrogaster). A.J. Grippo, S.M. Allen,D.L. Chandler, P. Dave, V. McDaniel and N. McNeal. NorthernIllinois Univ.D517 625.10 Effect of pyridostigmine on the sympathovagalbalance and cardiac morphometry in heart failure. R.M. Lataro,C.A.A. Silva, C.M. Prado, M.A. Rossi, R. Fazan, Jr. and H.C.Salgado. Sch. of Med. of Ribeirão Preto, Univ. of São Paulo.D518 625.11 Galanin reduces cardiac vagal acetylcholinerelease and bradycardia via a GalR1, protein kinase Cdependent pathway. N. Herring, J. Cranley, M.N. Lokale, B.Habecker and D.J. Paterson. Oxford Univ. and Sch. of Med.,Oregon Hlth. & Sci. Univ.D519 625.12 Hindlimb unloading results in loss of circadiancontrol of heart rate and increased incidence of spontaneousventricular arrhythmias. K.C. Welliver, A.J. Jepson and J.A.Moffitt. Des Moines Univ.D520 625.13 Maternal diabetes increases smallconductance Ca 2+ -activated K + currents which alters actionpotential properties and excitability of cardiac motoneurons inthe nucleus ambiguus. M. Lin, Q-H. Chen, L. Li, R.D. Wursterand Z. Cheng. Col. of Med., Univ. of Central Florida, Univ. ofTexas Hlth. Sci. Ctr. at San Antonio and Loyola Univ. Med. Ctr.D521 625.14 Does infusion of Bacillus anthracis toxinsproduce sympathoinhibition? M.J. Kenney and R.J. Fels.Kansas State Univ.D522 625.15 Role of epinephrine in 5HT 1Areceptor agonistmediatedincrease in venous tone during hypovolemic shock.R.L. Tiniakov and K.E. Scrogin. Loyola Univ. Chicago StritchSch. of Med.D523 625.16 Muscle metaboreflex-induced coronaryvasoconstriction limits left ventricular performance-blood flowrelationship. M. Coutsos, J.A. Sala-Mercado, M. Ishinose, Z.Li and D.S. O’Leary. Wayne State Univ. Sch. of Med., MeijiUniv., Tokyo and Qilu Hosp. of Shandong Univ., People’sRepublic of China.D524 625.17 Effects of hyper- and hypocapnea on choroidaland retinal blood flows and the visual acuity. N. Hayashi, N.Someya and T. Ikemura. Kyushu Univ., Japan.D525 625.18 Sympathetic overactivity in sinoaorticdenervated C57BL mice. F.L. Rodrigues, M. Oliveira, V.J.Dias da Silva, H.C. Salgado and R. Fazan, Jr. Sch. of Med. ofRibeirao Preto USP and Fed. Univ. of Triangulo Mineiro, Brazil.D526 625.19 Age-related changes in autonomic controlduring sleep: symbolic and complexity analyses of heart ratevariability. E. Tobaldini, A. Viola, S. Chellappa, A. Porta, K.R.Casali and N. Montano. Sacco Hosp., Milan, Univ. of Basel,Univ. of Milan and Univ. of Rio Grande do Sul, Brazil.626. microRNA, siRNA, and Other RegulatoryRNAPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD527 626.1 Micro RNA 802 stimulates ROMK channels bysuppressing caveolin-1 expression during a high potassiumintake. D. Lin, P. Yue, C. Pan, P. Sun and W. Wang. New YorkMed. Col.D528 626.2 A role for miR-471 in cardiac ischemiareperfusioninjury. B.J. Chun, M.W. Kidd, A. Eguchi, A.L.Moreno, S.F. Dowdy, P.M. Patel, D.M. Roth and H.H. Patel.UCSD , HHMI and VA San Diego Healthcare Syst.D529 626.3 Fetal disruption of microRNA expressionassociated with adult onset COPD-like lung disease in a ratmodel. J.C. Cohen, E. Killeen and J.E. Larson. Stony BrookUniv. and Thomas Jefferson Sch. of Med.D530 626.4 Effects of exercise on miRNA expression levelsin human peripheral blood mononuclear cells. S. Radom-Aizik,F. Zaldivar, S. Oliver, P. Galassetti and D.M. Cooper. Univ. ofCalifornia, Irvine.D531 626.5 Expression profile of radiation-responsivemicroRNAs in the human gastric cancer cell. Y. Shen and S.Kim. Kyung Hee Univ., Republic of Korea.D532 626.6 Post-transcriptional regulation of CD38expression in human airway smooth muscle cells. J.A. Jude, S.Puvanendiran, T. Walseth, J. Solway, R. Panettieri and M.S.Kannan. Univ. of Minnesota, St. Paul and Minneapolis, Univ. ofChicago and Univ. of Pennsylvania.D533 626.7 microRNA expression with aging in humanaortic endothelial cells. M. Blimline, D.R. Seals, A.J. Donato,B.S. Fleenor and C. Rippe. Univ. of Colorado at Boulder.D534 626.8 A developmentally noncoding RNA regulatesA. nidulans SYG1 plus gprB. J.G. Alcocer, K. Miller and B.Miller. Univ. of Idaho.D535 626.9 Nuclear factor-kappa beta regulates plateletactivating factor signaling in fetal ovine pulmonary vascularsmooth muscle cells. B.O. Ibe and L.S. Renteria. LABiomed.Res. Inst. at Harbor-UCLA Med. Ctr.627. Neuroendocrinology, Hypothalamusand PituitaryPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mphysiologyD536 627.1 Immunoregulation by the neurohypophysis. A.Quintanar-Stephano, C. Villalobos, K. Arroyo, A. Organista,M. Tinajero, R. Chavira, J. Ventura, M. Muñóz, R. Campos,H. Reyna, K. Kovacs and I. Berczi. Autonomous Univ. ofAguascalientes, Mexico, Inst. of Med. Sci. and Nutr., MexicoCity, IPN- Sch. of Med., Mexico City, St. Michael’s Hosp.,Toronto and Univ. of Manitoba, Canada.D537 627.2 Behavioral actions of neuropeptide W: moreevidence for a role in the stress response. A.N. Pate and W.K.Samson. Saint Louis Univ.D538 627.3 Nitric oxide and vasopressin expression duringsepsis. G.R. Oliveira-Pelegrin, L.A. Athayde, S.V. Azevedo,S. Yao, D. Murphy and M.J.A. Rocha. Fac. of Odontol. andFac. of Med. of Ribeirão Preto, Brazil and Univ. of Bristol, U.K.D539 627.4 Morphological restoration of pituitarythyrotrope population by thymulin gene therapy in nude mice.E.V. Martines, P. Reggiani, R. Goya and G. Cónsole. Univ.Adventista del Plata and Natl. Univ. of la Plata, Argentina.D540 627.5 High fat feeding inhibits the hypothalamopituitarygonadal axis and ovulation in diet-induced obese rats.P. Balasubramanian, L.K. Jagannathan, E.T. Gilbreath, M.Subramanian, P.S. Mohankumar and S.M.J. Mohankumar.Michigan State Univ.sun183

PhysiologyD541 627.6 Mechanisms of impaired vasopressin responsein acute alcohol-intoxicated hemorrhaged rats. A.M. Whitaker,J. Sulzer, J. Porter and P. Molina. LSU Hlth. Sci. Ctr., NewOrleans.D542 627.7 Estrogen modulation of neuropeptide Yreceptor signaling in magnocellular oxytocin neurons of thehypothalamus. J.H. Urban, A.M. Mitzey, M.S. Brownfield,M.M. Oblinger and W.E. Chura. Rosalind Franklin Univ. andUniv. of Wisconsin-Madison.D543 627.8 TRPV1 channels contribute to hyperosmoticinducedrelease of vasopressin from somata and dendritesof magnocellular neuroendocrine cells in supraoptic punches.C.S. Beitzel, J. Castillo, M. Valdez, A. Shahidzadeh, K.Spurgin, R. Calma and M. Curras-Collazo. Univ. of California,Riverside.628. Lipid, Lipoprotein and CholesterolMetabolismPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD544 628.1 Second hand smoke exposure mediatesoxidative modification of plasma apolipoprotein E. V.Narayanaswami, C. Gallo, M. Amaya, S. Tamamizu-Kato, O.Akintunde, D. Uyeminami, K. Pinkerton, K. Uchida and M.Kosaraju. California State Univ., Long Beach, Children’s Hosp.Oakland Res. Inst., Univ. of California, Davis and Nagoya Univ.,Japan.D545 628.2 Nicotinic acid improves reverse cholesteroltransport in dogs. J. Le Bloc’h, V. Leray, T. Magot, M. Krempf,P. Nguyen and K. Ouguerram. INSERM U915, Nantes andNatl. Vet. Sch. of Nantes.D546 628.3 A systematically constructed conceptual modelof cholesterol metabolism. A. de Graaf, N.C.A. van de Pas,A.E.M. Soffers, R.A. Woutersen, B. van Ommen and I.M.C.Rietjens. TNO Quality of Life, Zeist and Wageningen Univ.,Netherlands.D547 628.4 Apolipoprotein E suppresses atherosclerosisby reducing leukocyte recruitment to atheroma. N. Gaudreault,N. Kumar, J. Possada and R. Raffai. UCSF.D548 628.5 Profiling across species for the identificationof optimal animal models of dyslipidemia. A.M. Strack,E. Carballo-Jane, V.H. Mendoza, K. Gagen, L. McNamara,J. Gorski, G. Eiermann, A. Petrov, T. Akiyama, A. Kulick,M. Donnelly, G. Voronin, R. Rosa, A-M. Cumiskey, K. Bekkari,L. Mitnaul, O. Puig, K.S. Koblan and B.K. Hubbard. MerckRes. Labs., Rahway, NJ.D549 628.6 High egg cholesterol consumption may notaffect blood serum cholesterol levels in elite athletes in training.S. Bui, J. Oliver, M. Mardock, A. Beihl and S.E. Riechman.Texas A&M Univ.D550 628.7 Increased systemic peroxynitrite levels anddecreased expressions of lipolytic proteins in obese-prone rats.B. Smith and S.X. Ma. David Geffen Sch. of Med. at UCLA andHarbor-UCLA Med. Ctr.629. Gestational, Fetal and NeonatalBiology, Including Mammary Gland andLactationPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p mD551 629.1 Expression of angiotensin II subtype 1areceptor during pregnancy in mouse. K. Chen and J.C. Rose.New York Downtown Hosp. and Wake Forest Univ. Sch. ofMed.D552 629.2 Chronic hypoxia decreases the expression ofPKCe and alters methylation status of PKCe promoter in H9c2cells. A. Patterson. Loma Linda Univ.D553 629.3 Placenta vitamin D signaling in preeclampsia.C. Wheeler, J.N. Benoit and C.M. Anderson. Red River H.S.,Grand Forks and Univ. of North Dakota.D554 629.4 Effect of surgical isolation of pituitary fromhypothalamic influences on corticotroph development in fetalsheep. J. Schwartz, M. Sandhu, K. Farrand, E. Szarek, C.McMillen, D. Houghton, R. Young and N-A. Saleh. Sch. ofMed., Griffith Univ., Australia, Arid Agr. Univ., Pakistan, Sch. ofBiomed. Sci., Univ. of Queensland, Univ. of Adelaide,Univ. ofSouth Australia and Monash Univ., Australia.D555 629.5 Effects of dietary carbohydrates on mineralmetabolism in lactating dams and their pups. V. Douard, A.Asgerally, S. Shapses, Y. Sabbagh and R. Ferraris. UMDNJ-New Jersey Med. Sch., Rutgers Univ. and Genzyme Corp.D556 629.6 Aldosterone levels are inversely correlated tosuperoxide dismutase acitivity in the low-birth-weight newborn.N.B. Ojeda, D.G. Romero, J.H. Dasinger, B.T. Alexander andP. Rhodes. Univ. of Mississippi Med. Ctr.D557 629.7 Maternal exercise dose response effect onfetal heart rate and variability. L.E. May, A.G. Glaros, K.M.Gustafson and R.R. Suminski. Kansas City Univ. of Med. andBiosci. and Kansas Univ. Med. Ctr.D558 629.8 High muscle mass in Oregon women isassociated with decreased antioxidant expression in theterm placenta. P.F. O’Tierney, A. Cedar, C. Morris and K.L.Thornburg. Oregon Hlth. & Sci. Univ.D559 629.9 Comparison of the effects of growth hormoneon MAC-T cells and primary mammary cells. L. McDonnell, T.Johnson and D.G. Peterson. California Polytech State Univ.,San Luis Obispo.630. Connective Tissue and Bone MetabolismPosterSu n. 7:30 a m—An a h e i m Co n v e n t i o n Ce n t e r, Ex h i b i t Ha l l CDPresentation time: 12:45 p m-3:00 p msundayD560 630.1 Trenbolone (17b-hydroxyestra-4,9,11-trien-3-one) protects against bone loss in gonadectomized malerodents. J.F. Yarrow, C.F. Conover, J. Lipinska, C. Santillana,S.E. Franz, T.J. Wronski and S.E. Borst. VA Med. Ctr. andUniv. of Florida.D561 630.2 Follicle-stimulating hormone, interleukin-1 andbone density in adult women. J.G. Cannon, M. Cortez-Cooper,E. Meaders, J. Stallings, S. Haddow, B. Kraj, G. Sloan and A.Mulloy. Sch. of Allied Hlth. Sci. and Sch. of Med., Med. Col. ofGeorgia.184

sundayD562 630.3 Mineralization of breast capsular tissue:changes in factors affecting apatite formation and growth. L.W.Hunter, N.V. Tran and V.M. Miller. Mayo Clin.D563 630.4 Effects of lifelong decreased IGF-1 onphysiological status in mice. S.M. Motch, C. Sell, R. Graboski,M. Matzko, J.T. Stout and R. McCarter. Penn State and DrexelUniv. Col. of Med.D564 630.5 Effects of daily insulin treatment on bone in ratsfollowing severe burn and disuse. L. Baer, H. Pidcoke, X. Wu,D. Silliman, T. Walters, J.C. Tou, S. Wolf and C. Wade. U.S.Army Inst. of Surg. Res., fort Sam Houston and West VirginiaUniv.D565 630.6 Interaction of the effects between estrogenreceptor-alpha polymorphism and physical activity or nutrient onbone mass in Japanese young women. H. Kondo, H. Fujino, S.Murakami, I. Takeda and A. Ishihara. Nagoya Women’s Univ.,Kobe Univ., Himeji Dokkyo Univ. and Kyoto Univ., Japan.physiologyD566 630.7 Folic acid mitigated homocysteine-mediateddecrease in bone blood flow and bone remodeling. M. Kandel,N. Tyagi, N. Qipshidze, C. Munjal, P. Basu, S. Givvimani, O.A.Abe, P.K. Mishra, U. Sen and S.C. Tyagi. Univ. of Louisville.D567 630.8 Cooperative role of NF-kB signaling andPARP-1 activity in the TNF-induced inhibition of PHEX geneexpression. P.R. Kiela, P.M. Majewski, R.D. Thurston, R.Ramalingam, A. Sabetisoofyani and F.K. Ghishan. Univ. ofArizona.D568 630.9 ALP to PTH ratio in young and old females.Z. Wilson, C. Lau, F. Caporaso, K. Sumida and F. Frisch.Chapman Univ.D569 630.10 ALP trends in men and women. Z. Wilson, C.Lau, F. Caporaso, K. Sumida and F. Frisch. Chapman Univ.Join Us Next Year!Experimental Biology 2011sunApril 9 – 13Washington, DCAmerican Association of AnatomistsThe American Physiological SocietyAmerican Society for Biochemistry and Molecular BiologyAmerican Society for Investigative PathologyAmerican Society for NutritionAmerican Society for Pharmacology and Experimental TherapeuticsFor further information:www.experimentalbiology.org185

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sunday, april 25 across societies â Experimental Biology