CA2244732A1 - Laser opto-acoustic imaging system - Google Patents

Laser opto-acoustic imaging system

Info

Publication number
CA2244732A1
CA2244732A1 CA002244732A CA2244732A CA2244732A1 CA 2244732 A1 CA2244732 A1 CA 2244732A1 CA 002244732 A CA002244732 A CA 002244732A CA 2244732 A CA2244732 A CA 2244732A CA 2244732 A1 CA2244732 A1 CA 2244732A1
Authority
CA
Canada
Prior art keywords
tissue
laser
acoustic
pressure profile
stress
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002244732A
Other languages
French (fr)
Other versions
CA2244732C (en
Inventor
Alexander A. Oraevsky
Steven L. Jacques
Rinat O. Esenaliev
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Individual
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2244732A1 publication Critical patent/CA2244732A1/en
Application granted granted Critical
Publication of CA2244732C publication Critical patent/CA2244732C/en
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
    • G01N21/1702—Systems in which incident light is modified in accordance with the properties of the material investigated with opto-acoustic detection, e.g. for gases or analysing solids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/0093—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy
    • A61B5/0095—Detecting, measuring or recording by applying one single type of energy and measuring its conversion into another type of energy by applying light and detecting acoustic waves, i.e. photoacoustic measurements
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B5/00—Measuring for diagnostic purposes; Identification of persons
    • A61B5/145—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue
    • A61B5/1455—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters
    • A61B5/1459—Measuring characteristics of blood in vivo, e.g. gas concentration, pH value; Measuring characteristics of body fluids or tissues, e.g. interstitial fluid, cerebral tissue using optical sensors, e.g. spectral photometrical oximeters invasive, e.g. introduced into the body by a catheter
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B8/00—Diagnosis using ultrasonic, sonic or infrasonic waves
    • A61B8/08—Detecting organic movements or changes, e.g. tumours, cysts, swellings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K49/00—Preparations for testing in vivo
    • A61K49/22—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations
    • A61K49/222—Echographic preparations; Ultrasound imaging preparations ; Optoacoustic imaging preparations characterised by a special physical form, e.g. emulsions, liposomes
    • A61K49/225—Microparticles, microcapsules
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00017—Electrical control of surgical instruments
    • A61B2017/00115—Electrical control of surgical instruments with audible or visual output
    • A61B2017/00128—Electrical control of surgical instruments with audible or visual output related to intensity or progress of surgical action
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00844—Feedback systems
    • A61F2009/00851—Optical coherence topography [OCT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/007—Methods or devices for eye surgery
    • A61F9/008—Methods or devices for eye surgery using laser
    • A61F2009/00897—Scanning mechanisms or algorithms

Abstract

The present invention provides a system and principles of laser photo-acoustic imaging and tomography. The basis for laser photo-acoustic tomography is the time resolved detection of laser induced transient stress waves, selectively generated in absorbing tissues of diagnostic interest. Such a technique allows to visualize absorbed light distribution in turbid biological tissues irradiated by short laser pulses. Laser photo-acoustic tomography can be used for detection of tissue pathological changes that result in increased concentration of various tissue chromophore such as hemoglobin or development of enhanced micro-circulation in diseased tissue. The invented technology combines the advantages of pulsed laser excitation with time resolved detection of acoustic transients. The invented technology can be used for determination of optical heterogeneities in biological tissues. These heterogeneities include blood vessels, tissue layers, abnormal tissues and damaged tissues with further reconstruction of 3D tomographic images of human organs or portions thereof.

Claims (20)

1. A method of characterizing a tissue using laser optoacoustic imaging, comprising the steps of:
irradiating a volume of said tissue with at least one laser pulse so as to penetrate said tissue and selectively heat a small volume or layer of said tissue with a higher optical absorption causing the tissue to produce a pressure profile confined in said volume or layer of said tissue, wherein said pressure profile reflects a value of pressure as a function of depth in said tissue, and wherein said pressure profile of said tissue is characteristic of said tissue;
detecting said pressure profile with at least one acoustic transducer;
recording an amplitude and temporal profile of said pressure profile by an electronic system;
analyzing said pressure profile with a computer.
2. The method of claim 1, wherein said stress profiles are recorded and analyzed by the computer to reconstruct a three-dimensional image.
3. The method of claim 1, wherein said laser pulse heats certain tissue structures with different light absorption thereby generating stress profiles resembling profiles of absorbed laser energy distribution in heterogeneous tissues followed by time-resolved detection of ultrasonic stress waves.
4. The method of claim 1, wherein the shape and dimensions of said diseased tissue volume or layer is determined from the temporal profile of laser-induced stress, the time of stress wave arrival to the accoustic transducer, and the direction of the stress detection.
5. The method of claim 20, wherein the acoustic detector is a piezoelectric or optical detector capable of detecting pressure profiles within a wide ultrasonic frequency range.
6. The method of claim 1, wherein said stress wave is detected with an acoustic transducer using temporal resolution.
7. The method of claim 1, wherein said transducer determines a geometry of the characterized tissue volume by positioning a multiple of acoustic transducers at fixed locations along the surface of said characterized tissue.
8. The method of claim 1, wherein said multiple separate optical fibers or laser beams irradiate large volume of tissue to reduce time of scanning and incident laser fluence.
9. The method of claim 1, wherein said amplitude and temporal profile of laser-induced stress wave is recorded by a digital oscilloscope.
10 . The method of claim 1, wherein said stress detection is in transmission mode.
11 . The method of claim 1, wherein said stress detection of tissue optical heterogeneities occurs at a tissue depth of up to about 12 cm.
12. The method of claim 1, wherein said stress detection is in reflection mode.
13 . The method of claim 1, wherein said irradiating is in a spectral range of from about 600 nm to about 1400 nm.
14 . The method of claim 1, wherein said irradiating is at at a wavelength that corresponds to the absorption band of molecules, cells or tissues of diagnostic interest.
15. The method of claim 1, further comprising use of exogenous molecular probes or dyes to enhance contrast between pressure profiles of different tissues.
16. The method of claim 1, wherein said diseased tissue is selected from the group consisting of breast carcinoma, brain hemorrhages, hematomas, atherosclerotic plaques, polyarhtritis, port-wine stains, skin disorders, melanomas and ocular diseases.
17. The method of claim 1, wherein said diseased tissue is an internal organ, and wherein irradiation is delivered via endoscopes and said acoustic transducer is positioned on the skin surface.
18. The method of claim 1, wherein said diseased tissue is an internal organ, and wherein irradiation is delivered onto the skin surface and said transducer is incorporated with an endoscope and positioned inside the organs.
19. The method of claim 1, wherein said diseased tissue is an internal organ, and wherein an optical fiber and transducer are incorporated in endoscope and positioned inside the organs.
20. An imaging system for biomedical diagnostics comprising:
a pulsed optical source to produce conditions of pressure profile confinement in a volume of tissue of diagnostic interest;
a light delivery system for delivery of radiation to said tissue of diagnostic interest;
at least one acoustic detector to detect said pressure profile in said volume of tissue of diagnostic interest;
an electronic system for recording and processing of said detected pressure profile; and a computer with software for image reconstruction and analysis of said detected pressure profile.
CA2244732A 1996-01-31 1997-01-31 Laser opto-acoustic imaging system Expired - Lifetime CA2244732C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/594,758 1996-01-31
US08/594,758 US5840023A (en) 1996-01-31 1996-01-31 Optoacoustic imaging for medical diagnosis
PCT/US1997/001815 WO1997027801A1 (en) 1996-01-31 1997-01-31 Laser opto-acoustic imaging system

Publications (2)

Publication Number Publication Date
CA2244732A1 true CA2244732A1 (en) 1997-08-07
CA2244732C CA2244732C (en) 2010-04-20

Family

ID=24380282

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2244732A Expired - Lifetime CA2244732C (en) 1996-01-31 1997-01-31 Laser opto-acoustic imaging system

Country Status (7)

Country Link
US (1) US5840023A (en)
EP (1) EP0920277B1 (en)
JP (1) JPH11514549A (en)
AU (1) AU732799B2 (en)
CA (1) CA2244732C (en)
DE (1) DE69734203T2 (en)
WO (1) WO1997027801A1 (en)

Families Citing this family (312)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5585112A (en) 1989-12-22 1996-12-17 Imarx Pharmaceutical Corp. Method of preparing gas and gaseous precursor-filled microspheres
US5776429A (en) 1989-12-22 1998-07-07 Imarx Pharmaceutical Corp. Method of preparing gas-filled microspheres using a lyophilized lipids
US5542935A (en) 1989-12-22 1996-08-06 Imarx Pharmaceutical Corp. Therapeutic delivery systems related applications
US6146657A (en) 1989-12-22 2000-11-14 Imarx Pharmaceutical Corp. Gas-filled lipid spheres for use in diagnostic and therapeutic applications
US6088613A (en) 1989-12-22 2000-07-11 Imarx Pharmaceutical Corp. Method of magnetic resonance focused surgical and therapeutic ultrasound
US5922304A (en) 1989-12-22 1999-07-13 Imarx Pharmaceutical Corp. Gaseous precursor filled microspheres as magnetic resonance imaging contrast agents
US6551576B1 (en) 1989-12-22 2003-04-22 Bristol-Myers Squibb Medical Imaging, Inc. Container with multi-phase composition for use in diagnostic and therapeutic applications
US5874062A (en) 1991-04-05 1999-02-23 Imarx Pharmaceutical Corp. Methods of computed tomography using perfluorocarbon gaseous filled microspheres as contrast agents
US5205290A (en) 1991-04-05 1993-04-27 Unger Evan C Low density microspheres and their use as contrast agents for computed tomography
US20080154257A1 (en) * 2006-12-22 2008-06-26 Shiva Sharareh Real-time optoacoustic monitoring with electophysiologic catheters
US6743779B1 (en) 1994-11-29 2004-06-01 Imarx Pharmaceutical Corp. Methods for delivering compounds into a cell
US5997898A (en) 1995-06-06 1999-12-07 Imarx Pharmaceutical Corp. Stabilized compositions of fluorinated amphiphiles for methods of therapeutic delivery
US6231834B1 (en) 1995-06-07 2001-05-15 Imarx Pharmaceutical Corp. Methods for ultrasound imaging involving the use of a contrast agent and multiple images and processing of same
US6139819A (en) 1995-06-07 2000-10-31 Imarx Pharmaceutical Corp. Targeted contrast agents for diagnostic and therapeutic use
US6033645A (en) 1996-06-19 2000-03-07 Unger; Evan C. Methods for diagnostic imaging by regulating the administration rate of a contrast agent
US6521211B1 (en) 1995-06-07 2003-02-18 Bristol-Myers Squibb Medical Imaging, Inc. Methods of imaging and treatment with targeted compositions
US6309352B1 (en) * 1996-01-31 2001-10-30 Board Of Regents, The University Of Texas System Real time optoacoustic monitoring of changes in tissue properties
US6405069B1 (en) * 1996-01-31 2002-06-11 Board Of Regents, The University Of Texas System Time-resolved optoacoustic method and system for noninvasive monitoring of glucose
JP2001507207A (en) 1996-05-01 2001-06-05 イマアーレクス・フアーマシユーチカル・コーポレーシヨン Methods for delivering compounds to cells
US6414139B1 (en) 1996-09-03 2002-07-02 Imarx Therapeutics, Inc. Silicon amphiphilic compounds and the use thereof
CA2263568C (en) 1996-09-11 2008-12-02 Imarx Pharmaceutical Corp. Methods for diagnostic imaging using a contrast agent and a renal vasodilator
US5713356A (en) * 1996-10-04 1998-02-03 Optosonics, Inc. Photoacoustic breast scanner
US6745067B1 (en) * 1998-09-14 2004-06-01 Lucid, Inc. System for marking the locations of imaged tissue with respect to the surface of the tissue
US6424852B1 (en) * 1996-10-18 2002-07-23 Lucid, Inc. System for confocal imaging within dermal tissue
GB9704737D0 (en) * 1997-03-07 1997-04-23 Optel Instr Limited Biological measurement system
US6143276A (en) 1997-03-21 2000-11-07 Imarx Pharmaceutical Corp. Methods for delivering bioactive agents to regions of elevated temperatures
US6537246B1 (en) 1997-06-18 2003-03-25 Imarx Therapeutics, Inc. Oxygen delivery agents and uses for the same
US6090800A (en) 1997-05-06 2000-07-18 Imarx Pharmaceutical Corp. Lipid soluble steroid prodrugs
US6416740B1 (en) 1997-05-13 2002-07-09 Bristol-Myers Squibb Medical Imaging, Inc. Acoustically active drug delivery systems
GB9712524D0 (en) * 1997-06-16 1997-08-20 Nycomed Imaging As Method
US6548047B1 (en) 1997-09-15 2003-04-15 Bristol-Myers Squibb Medical Imaging, Inc. Thermal preactivation of gaseous precursor filled compositions
US6091981A (en) * 1997-09-16 2000-07-18 Assurance Medical Inc. Clinical tissue examination
US6063031A (en) * 1997-10-14 2000-05-16 Assurance Medical, Inc. Diagnosis and treatment of tissue with instruments
US6123923A (en) 1997-12-18 2000-09-26 Imarx Pharmaceutical Corp. Optoacoustic contrast agents and methods for their use
US20010003580A1 (en) 1998-01-14 2001-06-14 Poh K. Hui Preparation of a lipid blend and a phospholipid suspension containing the lipid blend
US5977538A (en) * 1998-05-11 1999-11-02 Imarx Pharmaceutical Corp. Optoacoustic imaging system
US6104942A (en) * 1998-05-12 2000-08-15 Optosonics, Inc. Thermoacoustic tissue scanner
US6478735B1 (en) * 1999-01-28 2002-11-12 The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration Physiological feedback method and system
US6216025B1 (en) 1999-02-02 2001-04-10 Optosonics, Inc. Thermoacoustic computed tomography scanner
GB9915082D0 (en) * 1999-06-28 1999-08-25 Univ London Optical fibre probe
AU6894500A (en) 1999-08-06 2001-03-05 Board Of Regents, The University Of Texas System Optoacoustic monitoring of blood oxygenation
US6253621B1 (en) 1999-08-31 2001-07-03 Advanced Micro Devices Micro-void detection
US6212421B1 (en) * 1999-09-03 2001-04-03 Lockheed Martin Energy Research Corp. Method and apparatus of spectro-acoustically enhanced ultrasonic detection for diagnostics
US6421811B1 (en) 1999-09-30 2002-07-16 Advanced Micro Devices, Inc. Defect detection via acoustic analysis
US6277656B1 (en) 1999-09-30 2001-08-21 Rama R. Goruganthu Substrate removal as a function of acoustic analysis
US6430728B1 (en) 1999-09-30 2002-08-06 Advanced Micro Devices, Inc. Acoustic 3D analysis of circuit structures
WO2001035881A1 (en) * 1999-11-12 2001-05-25 Thomas Bende Non-contact photoacoustic spectroscopy for photoablation control
US6751490B2 (en) 2000-03-01 2004-06-15 The Board Of Regents Of The University Of Texas System Continuous optoacoustic monitoring of hemoglobin concentration and hematocrit
GB0015250D0 (en) * 2000-06-22 2000-08-16 Payne Peter A Ophthalmic uses of lasers
IL138073A0 (en) * 2000-08-24 2001-10-31 Glucon Inc Photoacoustic assay and imaging system
US6673334B1 (en) * 2000-10-16 2004-01-06 Mallinkcrodt, Inc. Light sensitive compounds for instant determination of organ function
US6669926B1 (en) * 2000-10-16 2003-12-30 Mallinckrodt, Inc. Hydrophilic light absorbing indole compounds for determination of physiological function in critically ill patients
EP1434522B1 (en) 2000-10-30 2010-01-13 The General Hospital Corporation Optical systems for tissue analysis
US9295391B1 (en) 2000-11-10 2016-03-29 The General Hospital Corporation Spectrally encoded miniature endoscopic imaging probe
US7179449B2 (en) * 2001-01-30 2007-02-20 Barnes-Jewish Hospital Enhanced ultrasound detection with temperature-dependent contrast agents
JP2002272738A (en) * 2001-03-21 2002-09-24 Fuji Photo Film Co Ltd Ultrasonic diagnostic equipment
AT503309B1 (en) 2001-05-01 2011-08-15 Gen Hospital Corp DEVICE FOR DETERMINING ATHEROSCLEROTIC BEARING BY MEASURING OPTICAL TISSUE PROPERTIES
US6490470B1 (en) 2001-06-19 2002-12-03 Optosonics, Inc. Thermoacoustic tissue scanner
US20050085725A1 (en) * 2001-08-09 2005-04-21 Ron Nagar Photoacoustic assay and imaging system
US6980299B1 (en) 2001-10-16 2005-12-27 General Hospital Corporation Systems and methods for imaging a sample
US7077565B2 (en) * 2001-11-15 2006-07-18 Glucon, Inc. Method for measuring temperature of substances from measurement of absorption coefficients
JP2005530128A (en) 2002-01-11 2005-10-06 ザ・ジェネラル・ホスピタル・コーポレイション Apparatus for OCT imaging using axial line focus to improve resolution and depth regions
US7355716B2 (en) 2002-01-24 2008-04-08 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7322972B2 (en) * 2002-04-10 2008-01-29 The Regents Of The University Of California In vivo port wine stain, burn and melanin depth determination using a photoacoustic probe
AU2003238655A1 (en) * 2002-06-25 2004-01-06 Glucon Inc. Method and apparatus for determining tissue viability
EP1524938A2 (en) * 2002-07-12 2005-04-27 Iscience Surgical Corporation Ultrasound interfacing device for tissue imaging
ATE424758T1 (en) 2002-07-26 2009-03-15 Univ Texas CONTINUOUS OPTOACOUSTIC MONITORING OF HEMOGLOBIN CONCENTRATION AND HEMATOCRIT
CA2514189A1 (en) 2003-01-24 2004-08-12 The General Hospital Corporation System and method for identifying tissue using low-coherence interferometry
US7567349B2 (en) 2003-03-31 2009-07-28 The General Hospital Corporation Speckle reduction in optical coherence tomography by path length encoded angular compounding
US7643153B2 (en) 2003-01-24 2010-01-05 The General Hospital Corporation Apparatus and method for ranging and noise reduction of low coherence interferometry LCI and optical coherence tomography OCT signals by parallel detection of spectral bands
US7500953B2 (en) * 2003-01-25 2009-03-10 Seno Medical Instruments, Inc. High contrast optoacoustic imaging using nanoparticles
US7430445B2 (en) * 2003-04-24 2008-09-30 The Board Of Regents Of The University Of Texas System Noninvasive blood analysis by optical probing of the veins under the tongue
KR20130138867A (en) 2003-06-06 2013-12-19 더 제너럴 하스피탈 코포레이션 Process and apparatus for a wavelength tunning source
JP4406226B2 (en) * 2003-07-02 2010-01-27 株式会社東芝 Biological information video device
CN103181754A (en) 2003-10-27 2013-07-03 通用医疗公司 Method and apparatus for performing optical imaging using frequency-domain interferometry
WO2005054780A1 (en) 2003-11-28 2005-06-16 The General Hospital Corporation Method and apparatus for three-dimensional spectrally encoded imaging
US20050124897A1 (en) * 2003-12-03 2005-06-09 Scimed Life Systems, Inc. Apparatus and methods for delivering acoustic energy to body tissue
JP4643153B2 (en) 2004-02-06 2011-03-02 株式会社東芝 Non-invasive biological information imaging device
EP2336747B1 (en) 2004-05-06 2017-08-30 Nippon Telegraph And Telephone Corporation Component concentration measuring device
WO2005117534A2 (en) 2004-05-29 2005-12-15 The General Hospital Corporation Process, system and software arrangement for a chromatic dispersion compensation using reflective layers in optical coherence tomography (oct) imaging
US7447408B2 (en) 2004-07-02 2008-11-04 The General Hospital Corproation Imaging system and related techniques
AT414212B (en) * 2004-07-20 2006-10-15 Upper Austrian Res Gmbh THERMOACUSTIC TOMOGRAPHY PROCESS AND THERMOACUSTIC TOMOGRAPH
US8081316B2 (en) 2004-08-06 2011-12-20 The General Hospital Corporation Process, system and software arrangement for determining at least one location in a sample using an optical coherence tomography
EP1793730B1 (en) 2004-08-24 2011-12-28 The General Hospital Corporation Process, system and software arrangement for determining elastic modulus
KR20120062944A (en) 2004-08-24 2012-06-14 더 제너럴 하스피탈 코포레이션 Method and apparatus for imaging of vessel segments
KR101269455B1 (en) 2004-09-10 2013-05-30 더 제너럴 하스피탈 코포레이션 System and method for optical coherence imaging
JP4997112B2 (en) 2004-09-29 2012-08-08 ザ ジェネラル ホスピタル コーポレイション Apparatus for transmitting at least one electromagnetic radiation and method of manufacturing the same
JP5623692B2 (en) 2004-11-02 2014-11-12 ザ ジェネラル ホスピタル コーポレイション Optical fiber rotator, optical system and method for sample imaging
US7995210B2 (en) 2004-11-24 2011-08-09 The General Hospital Corporation Devices and arrangements for performing coherence range imaging using a common path interferometer
EP1816949A1 (en) 2004-11-29 2007-08-15 The General Hospital Corporation Arrangements, devices, endoscopes, catheters and methods for performing optical imaging by simultaneously illuminating and detecting multiple points on a sample
US8185189B2 (en) * 2004-12-20 2012-05-22 Koninklijke Philips Electronics N.V. Investigation of body structures
IL166408A0 (en) * 2005-01-20 2006-01-15 Ultraview Ltd Combined 2d pulse-echo ultrasound and optoacousticsignal for glaucoma treatment
US20060184042A1 (en) * 2005-01-22 2006-08-17 The Texas A&M University System Method, system and apparatus for dark-field reflection-mode photoacoustic tomography
EP1875436B1 (en) 2005-04-28 2009-12-09 The General Hospital Corporation Evaluation of image features of an anatomical structure in optical coherence tomography images
WO2006130797A2 (en) 2005-05-31 2006-12-07 The General Hospital Corporation Spectral encoding heterodyne interferometry techniques for imaging
JP5702049B2 (en) 2005-06-01 2015-04-15 ザ ジェネラル ホスピタル コーポレイション Apparatus, method and system for performing phase resolved optical frequency domain imaging
US20070015992A1 (en) * 2005-06-30 2007-01-18 General Electric Company System and method for optoacoustic imaging
ES2354287T3 (en) 2005-08-09 2011-03-11 The General Hospital Corporation APPARATUS AND METHOD FOR PERFORMING A DEMODULATION IN QUADRATURE BY POLARIZATION IN OPTICAL COHERENCE TOMOGRAPHY.
JP6046325B2 (en) 2005-09-29 2016-12-14 ザ ジェネラル ホスピタル コーポレイション Method and apparatus for the observation and analysis of one or more biological samples with progressively increased resolution
US7889348B2 (en) 2005-10-14 2011-02-15 The General Hospital Corporation Arrangements and methods for facilitating photoluminescence imaging
WO2007082228A1 (en) 2006-01-10 2007-07-19 The General Hospital Corporation Systems and methods for generating data based on one or more spectrally-encoded endoscopy techniques
WO2007084981A2 (en) * 2006-01-19 2007-07-26 The Regents Of The University Of Michigan System and method for photoacoustic imaging and monitoring of laser therapy
CN104257348A (en) 2006-01-19 2015-01-07 通用医疗公司 Methods And Systems For Optical Imaging Of Epithelial Luminal Organs By Beam Scanning Thereof
WO2007084903A2 (en) 2006-01-19 2007-07-26 The General Hospital Corporation Apparatus for obtaining information for a structure using spectrally-encoded endoscopy techniques and method for producing one or more optical arrangements
US20090054763A1 (en) * 2006-01-19 2009-02-26 The Regents Of The University Of Michigan System and method for spectroscopic photoacoustic tomography
US7740585B2 (en) * 2006-01-20 2010-06-22 Seno Medical Instruments, Inc. Quantitative optoacoustic tomography with enhanced contrast
US8135450B2 (en) * 2006-01-20 2012-03-13 Esenaliev Rinat O Noninvasive glucose sensing methods and systems
WO2007149601A2 (en) 2006-02-01 2007-12-27 The General Hospital Corporation Apparatus for controlling at least one of at least two sections of at least one fiber
JP5524487B2 (en) 2006-02-01 2014-06-18 ザ ジェネラル ホスピタル コーポレイション A method and system for emitting electromagnetic radiation to at least a portion of a sample using a conformal laser treatment procedure.
EP1986545A2 (en) 2006-02-01 2008-11-05 The General Hospital Corporation Apparatus for applying a plurality of electro-magnetic radiations to a sample
EP1988825B1 (en) 2006-02-08 2016-12-21 The General Hospital Corporation Arrangements and systems for obtaining information associated with an anatomical sample using optical microscopy
WO2007101026A2 (en) 2006-02-24 2007-09-07 The General Hospital Corporation Methods and systems for performing angle-resolved fourier-domain optical coherence tomography
US7750536B2 (en) 2006-03-02 2010-07-06 Visualsonics Inc. High frequency ultrasonic transducer and matching layer comprising cyanoacrylate
CN101466298B (en) 2006-04-05 2011-08-31 通用医疗公司 Methods arrangements and systems for polarization-sensitive optical frequency domain imaging of a sample
EP3150110B1 (en) 2006-05-10 2020-09-02 The General Hospital Corporation Processes, arrangements and systems for providing frequency domain imaging of a sample
WO2007133964A2 (en) * 2006-05-12 2007-11-22 The General Hospital Corporation Processes, arrangements and systems for providing a fiber layer thickness map based on optical coherence tomography images
CN100456016C (en) * 2006-05-30 2009-01-28 华南师范大学 Multi-channel electronic parallel scanning photoacoustic real-time tomo graphic-imaging method and apparatus thereof
US20070291275A1 (en) * 2006-06-16 2007-12-20 Prescient Medical, Inc. Side-viewing optical acoustic sensors and their use in intravascular diagnostic probes
US8501099B2 (en) * 2006-07-11 2013-08-06 The Curators Of The University Of Missouri Photo-acoustic detection device and method
US7968347B2 (en) * 2006-07-11 2011-06-28 The Curators Of The University Of Missouri Photo-acoustic detection device and method
JP2010501877A (en) 2006-08-25 2010-01-21 ザ ジェネラル ホスピタル コーポレイション Apparatus and method for improving optical coherence tomography imaging capabilities using volumetric filtering techniques
US8219170B2 (en) 2006-09-20 2012-07-10 Nellcor Puritan Bennett Llc System and method for practicing spectrophotometry using light emitting nanostructure devices
US8396527B2 (en) 2006-09-22 2013-03-12 Covidien Lp Medical sensor for reducing signal artifacts and technique for using the same
US8195264B2 (en) 2006-09-22 2012-06-05 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
US8175671B2 (en) 2006-09-22 2012-05-08 Nellcor Puritan Bennett Llc Medical sensor for reducing signal artifacts and technique for using the same
WO2008049118A2 (en) 2006-10-19 2008-04-24 The General Hospital Corporation Apparatus and method for obtaining and providing imaging information associated with at least one portion of a sample and effecting such portion(s)
WO2008067438A2 (en) * 2006-11-29 2008-06-05 The Regents Of University Of Michigan System and method for photoacoustic guided diffuse optical imaging
EP1935346A1 (en) 2006-12-21 2008-06-25 Stichting voor de Technische Wetenschappen Imaging apparatus and method
US20080173093A1 (en) * 2007-01-18 2008-07-24 The Regents Of The University Of Michigan System and method for photoacoustic tomography of joints
US7911621B2 (en) 2007-01-19 2011-03-22 The General Hospital Corporation Apparatus and method for controlling ranging depth in optical frequency domain imaging
EP2104968A1 (en) 2007-01-19 2009-09-30 The General Hospital Corporation Rotating disk reflection for fast wavelength scanning of dispersed broadband light
US20110021924A1 (en) * 2007-02-09 2011-01-27 Shriram Sethuraman Intravascular photoacoustic and utrasound echo imaging
WO2008103982A2 (en) * 2007-02-23 2008-08-28 The Regents Of The University Of Michigan System and method for monitoring photodynamic therapy
US20080228073A1 (en) * 2007-03-12 2008-09-18 Silverman Ronald H System and method for optoacoustic imaging of peripheral tissues
US20080234567A1 (en) * 2007-03-19 2008-09-25 The General Hospital Corporation Apparatus and method for providing a noninvasive diagnosis of internal bleeding
WO2008118781A2 (en) 2007-03-23 2008-10-02 The General Hospital Corporation Methods, arrangements and apparatus for utilizing a wavelength-swept laser using angular scanning and dispersion procedures
US10534129B2 (en) 2007-03-30 2020-01-14 The General Hospital Corporation System and method providing intracoronary laser speckle imaging for the detection of vulnerable plaque
US9380967B2 (en) 2007-04-11 2016-07-05 The Board Of Regents Of The University Of Texas System Systems and methods for measuring fetal cerebral oxygenation
US10226206B2 (en) 2007-04-11 2019-03-12 The Board Of Regents Of The University Of Texas System Systems and methods for measuring neonatal cerebral oxygenation
US20080255433A1 (en) * 2007-04-11 2008-10-16 The Board Of Regents Of The University Of Texas Syatem Optoacoustic monitoring of multiple parameters
WO2008131082A1 (en) 2007-04-17 2008-10-30 The General Hospital Corporation Apparatus and methods for measuring vibrations using spectrally-encoded endoscopy techniques
WO2008137637A2 (en) 2007-05-04 2008-11-13 The General Hospital Corporation Methods, arrangements and systems for obtaining information associated with a sample using brillouin microscopy
JP4739363B2 (en) * 2007-05-15 2011-08-03 キヤノン株式会社 Biological information imaging apparatus, biological information analysis method, and biological information imaging method
JP5595534B2 (en) * 2007-05-15 2014-09-24 キヤノン株式会社 Biological information imaging apparatus, biological information analysis method, and biological information imaging method
US7952719B2 (en) 2007-06-08 2011-05-31 Prescient Medical, Inc. Optical catheter configurations combining raman spectroscopy with optical fiber-based low coherence reflectometry
JP5349839B2 (en) * 2007-06-22 2013-11-20 キヤノン株式会社 Biological information imaging device
US20090024040A1 (en) * 2007-07-20 2009-01-22 Prescient Medical, Inc. Wall-Contacting Intravascular Ultrasound Probe Catheters
WO2009018456A2 (en) 2007-07-31 2009-02-05 The General Hospital Corporation Systems and methods for providing beam scan patterns for high speed doppler optical frequency domain imaging
US8361437B2 (en) 2007-08-28 2013-01-29 University Of Florida Research Foundation, Inc. Multimodal nanoparticles for non-invasive bio-imaging
JP5536650B2 (en) 2007-08-31 2014-07-02 ザ ジェネラル ホスピタル コーポレイション System and method for self-interfering fluorescence microscopy and associated computer-accessible media
JP5201920B2 (en) * 2007-09-12 2013-06-05 キヤノン株式会社 measuring device
JP5132228B2 (en) * 2007-09-12 2013-01-30 キヤノン株式会社 Measuring method and measuring device
US20090076395A1 (en) * 2007-09-19 2009-03-19 Prescient Medical, Inc. Optimized intravascular ultrasound probe catherers
US20090105588A1 (en) * 2007-10-02 2009-04-23 Board Of Regents, The University Of Texas System Real-Time Ultrasound Monitoring of Heat-Induced Tissue Interactions
WO2009050632A1 (en) 2007-10-16 2009-04-23 Koninklijke Philips Electronics N.V. Apparatus, systems and methods for production and integration of compact illumination schemes
EP3229010A3 (en) 2007-10-25 2018-01-10 Washington University in St. Louis Confocal photoacoustic microscopy with optical lateral resolution
US7933021B2 (en) 2007-10-30 2011-04-26 The General Hospital Corporation System and method for cladding mode detection
WO2009073979A1 (en) 2007-12-12 2009-06-18 Carson Jeffrey J L Three-dimensional photoacoustic imager and methods for calibrating an imager
CN101909516B (en) * 2007-12-28 2012-07-04 皇家飞利浦电子股份有限公司 Tissue ablation device with photoacoustic lesion formation feedback
DE102008017097A1 (en) 2008-01-17 2009-07-30 RUHR-UNIVERSITäT BOCHUM Method for photoacoustic generation of illustration, involves emitting light pulse sequence by light source, where light pulse sequence has two electromagnetic pulses
US9332942B2 (en) 2008-01-28 2016-05-10 The General Hospital Corporation Systems, processes and computer-accessible medium for providing hybrid flourescence and optical coherence tomography imaging
US11123047B2 (en) 2008-01-28 2021-09-21 The General Hospital Corporation Hybrid systems and methods for multi-modal acquisition of intravascular imaging data and counteracting the effects of signal absorption in blood
JP5284129B2 (en) * 2008-02-06 2013-09-11 キヤノン株式会社 Imaging apparatus and analysis method
EP2110076A1 (en) * 2008-02-19 2009-10-21 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Method and device for near-field dual-wave modality imaging
US9078617B2 (en) * 2008-03-17 2015-07-14 Or-Nim Medical Ltd. Apparatus for non-invasive optical monitoring
EP2274572A4 (en) 2008-05-07 2013-08-28 Gen Hospital Corp System, method and computer-accessible medium for tracking vessel motion during three-dimensional coronary artery microscopy
JP5795531B2 (en) 2008-06-20 2015-10-14 ザ ジェネラル ホスピタル コーポレイション Fused fiber optic coupler structure and method of using the same
JP4829934B2 (en) * 2008-07-11 2011-12-07 キヤノン株式会社 Inspection device
JP5667051B2 (en) 2008-07-14 2015-02-12 ザ ジェネラル ホスピタル コーポレイション Equipment for color endoscopy
WO2010009747A1 (en) * 2008-07-25 2010-01-28 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Quantitative multi-spectral opto-acoustic tomography (msot) of tissue biomarkers
WO2011000389A1 (en) 2009-06-29 2011-01-06 Helmholtz Zentrum München Deutsches Forschungszentrum Für Gesundheit Und Umwelt (Gmbh) Thermoacoustic imaging with quantitative extraction of absorption map
JP5419404B2 (en) * 2008-09-04 2014-02-19 キヤノン株式会社 Photoacoustic device
JP5451014B2 (en) * 2008-09-10 2014-03-26 キヤノン株式会社 Photoacoustic device
US8532751B2 (en) 2008-09-30 2013-09-10 Covidien Lp Laser self-mixing sensors for biological sensing
US8386000B2 (en) 2008-09-30 2013-02-26 Covidien Lp System and method for photon density wave pulse oximetry and pulse hemometry
US8433382B2 (en) 2008-09-30 2013-04-30 Covidien Lp Transmission mode photon density wave system and method
US8142368B2 (en) * 2008-10-02 2012-03-27 Artann Laboratories Inc. Method of characterization and differentiation of tissue
JP5305818B2 (en) * 2008-10-03 2013-10-02 キヤノン株式会社 Biological information acquisition device
JP5183406B2 (en) * 2008-10-03 2013-04-17 キヤノン株式会社 Biological information processing apparatus and biological information processing method
JP5235586B2 (en) * 2008-10-03 2013-07-10 キヤノン株式会社 Biological information processing apparatus and biological information processing method
JP5279435B2 (en) * 2008-10-03 2013-09-04 キヤノン株式会社 SUBJECT INFORMATION ACQUISITION DEVICE AND METHOD FOR CONTROLLING SUBJECT INFORMATION ACQUISITION DEVICE
JP2010088627A (en) * 2008-10-07 2010-04-22 Canon Inc Apparatus and method for processing biological information
EP2341832B1 (en) * 2008-10-13 2014-07-16 Academisch Medisch Centrum bij de Universiteit van Amsterdam Mammography-apparatus and method for screening the occurrence of malignant cells
US9528966B2 (en) * 2008-10-23 2016-12-27 Washington University Reflection-mode photoacoustic tomography using a flexibly-supported cantilever beam
EP3330696B1 (en) 2008-12-10 2023-07-12 The General Hospital Corporation Systems, apparatus and methods for extending imaging depth range of optical coherence tomography through optical sub-sampling
JP5241465B2 (en) * 2008-12-11 2013-07-17 キヤノン株式会社 Photoacoustic imaging apparatus and photoacoustic imaging method
US9351705B2 (en) 2009-01-09 2016-05-31 Washington University Miniaturized photoacoustic imaging apparatus including a rotatable reflector
JP2012515930A (en) 2009-01-26 2012-07-12 ザ ジェネラル ホスピタル コーポレーション System, method and computer-accessible medium for providing a wide-field super-resolution microscope
WO2010091190A2 (en) 2009-02-04 2010-08-12 The General Hospital Corporation Apparatus and method for utilization of a high-speed optical wavelength tuning source
US9351642B2 (en) 2009-03-12 2016-05-31 The General Hospital Corporation Non-contact optical system, computer-accessible medium and method for measurement at least one mechanical property of tissue using coherent speckle technique(s)
US20100245770A1 (en) * 2009-03-17 2010-09-30 Zhang Hao F Systems and methods for photoacoustic opthalmoscopy
BRPI1009366A2 (en) * 2009-04-20 2016-03-08 Univ Missouri in vitro solid tissue analyte detection method and system
US11490826B2 (en) 2009-07-14 2022-11-08 The General Hospital Corporation Apparatus, systems and methods for measuring flow and pressure within a vessel
EP2459987A1 (en) 2009-07-27 2012-06-06 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt (GmbH) Imaging device and method for optoacoustic imaging of small animals
JP5525787B2 (en) * 2009-09-14 2014-06-18 株式会社東芝 Biological information video device
US8494604B2 (en) 2009-09-21 2013-07-23 Covidien Lp Wavelength-division multiplexing in a multi-wavelength photon density wave system
US8788001B2 (en) 2009-09-21 2014-07-22 Covidien Lp Time-division multiplexing in a multi-wavelength photon density wave system
US8798704B2 (en) 2009-09-24 2014-08-05 Covidien Lp Photoacoustic spectroscopy method and system to discern sepsis from shock
US9057695B2 (en) * 2009-09-24 2015-06-16 Canon Kabushiki Kaisha Apparatus and method for irradiating a scattering medium with a reconstructive wave
EP2957232A1 (en) 2009-10-29 2015-12-23 Canon Kabushiki Kaisha Photoacoustic apparatus
CN104856728B (en) * 2009-10-29 2019-07-23 佳能株式会社 Photo-acoustic device
JP5538855B2 (en) 2009-12-11 2014-07-02 キヤノン株式会社 Photoacoustic apparatus and method for controlling the apparatus
JP5538856B2 (en) 2009-12-11 2014-07-02 キヤノン株式会社 Photoacoustic device
CN102655815B (en) 2009-12-17 2015-07-01 佳能株式会社 Measurement system and image forming method
NL2005509C2 (en) 2010-02-19 2011-08-23 Academisch Medisch Ct Bij De Universiteit Van Amsterdam Mammography-apparatus.
JP5448918B2 (en) * 2010-02-24 2014-03-19 キヤノン株式会社 Biological information processing device
US8804126B2 (en) 2010-03-05 2014-08-12 The General Hospital Corporation Systems, methods and computer-accessible medium which provide microscopic images of at least one anatomical structure at a particular resolution
US9086365B2 (en) 2010-04-09 2015-07-21 Lihong Wang Quantification of optical absorption coefficients using acoustic spectra in photoacoustic tomography
JP5641773B2 (en) * 2010-04-28 2014-12-17 キヤノン株式会社 measuring device
US9069130B2 (en) 2010-05-03 2015-06-30 The General Hospital Corporation Apparatus, method and system for generating optical radiation from biological gain media
EP2575597B1 (en) 2010-05-25 2022-05-04 The General Hospital Corporation Apparatus for providing optical imaging of structures and compositions
EP2575598A2 (en) 2010-05-25 2013-04-10 The General Hospital Corporation Apparatus, systems, methods and computer-accessible medium for spectral analysis of optical coherence tomography images
US10285568B2 (en) 2010-06-03 2019-05-14 The General Hospital Corporation Apparatus and method for devices for imaging structures in or at one or more luminal organs
JP5761935B2 (en) 2010-07-22 2015-08-12 キヤノン株式会社 Subject information acquisition apparatus, subject information acquisition method, and subject information acquisition program
US8930145B2 (en) 2010-07-28 2015-01-06 Covidien Lp Light focusing continuous wave photoacoustic spectroscopy and its applications to patient monitoring
WO2012024687A2 (en) * 2010-08-20 2012-02-23 Purdue Research Foundation Bond-selective vibrational photoacoustic imaging system and method
US20130109950A1 (en) * 2011-11-02 2013-05-02 Seno Medical Instruments, Inc. Handheld optoacoustic probe
US9289191B2 (en) 2011-10-12 2016-03-22 Seno Medical Instruments, Inc. System and method for acquiring optoacoustic data and producing parametric maps thereof
US8686335B2 (en) 2011-12-31 2014-04-01 Seno Medical Instruments, Inc. System and method for adjusting the light output of an optoacoustic imaging system
US9510758B2 (en) 2010-10-27 2016-12-06 The General Hospital Corporation Apparatus, systems and methods for measuring blood pressure within at least one vessel
US8817255B2 (en) 2010-12-17 2014-08-26 Canon Kabushiki Kaisha Apparatus and method for irradiating a scattering medium
US8954130B2 (en) 2010-12-17 2015-02-10 Canon Kabushiki Kaisha Apparatus and method for irradiating a medium
US8976433B2 (en) 2010-12-17 2015-03-10 Canon Kabushiki Kaisha Apparatus and method for irradiating a scattering medium
US8521247B2 (en) 2010-12-29 2013-08-27 Covidien Lp Certification apparatus and method for a medical device computer
US8997572B2 (en) 2011-02-11 2015-04-07 Washington University Multi-focus optical-resolution photoacoustic microscopy with ultrasonic array detection
RU2486501C2 (en) * 2011-02-28 2013-06-27 Александр Алексеевич Карабутов Laser optical-acoustic tomography method and apparatus for realising said method (versions)
WO2012125649A2 (en) * 2011-03-14 2012-09-20 Lawrence Livermore National Security, Llc Non-contact optical system for detecting ultrasound waves from a surface
JP5917012B2 (en) * 2011-04-11 2016-05-11 キヤノン株式会社 Laser apparatus and photoacoustic apparatus
WO2012149175A1 (en) 2011-04-29 2012-11-01 The General Hospital Corporation Means for determining depth-resolved physical and/or optical properties of scattering media
US10206607B2 (en) * 2011-04-29 2019-02-19 The Board Of Regents Of The University Of Texas System Methods and apparatus for optoacoustic guidance and confirmation of placement of indwelling medical apparatus
US9304490B2 (en) 2011-05-27 2016-04-05 Canon Kabushiki Kaisha Apparatus and method for irradiating a medium
WO2012174413A1 (en) 2011-06-15 2012-12-20 University Of Southern California Optical coherence photoacoustic microscopy
US9330092B2 (en) 2011-07-19 2016-05-03 The General Hospital Corporation Systems, methods, apparatus and computer-accessible-medium for providing polarization-mode dispersion compensation in optical coherence tomography
JP5917037B2 (en) 2011-07-29 2016-05-11 キヤノン株式会社 Subject information acquisition apparatus and subject information acquisition method
WO2013029047A1 (en) 2011-08-25 2013-02-28 The General Hospital Corporation Methods, systems, arrangements and computer-accessible medium for providing micro-optical coherence tomography procedures
EP2769491A4 (en) 2011-10-18 2015-07-22 Gen Hospital Corp Apparatus and methods for producing and/or providing recirculating optical delay(s)
US9055869B2 (en) 2011-10-28 2015-06-16 Covidien Lp Methods and systems for photoacoustic signal processing
US9730587B2 (en) * 2011-11-02 2017-08-15 Seno Medical Instruments, Inc. Diagnostic simulator
US9757092B2 (en) 2011-11-02 2017-09-12 Seno Medical Instruments, Inc. Method for dual modality optoacoustic imaging
US10433732B2 (en) 2011-11-02 2019-10-08 Seno Medical Instruments, Inc. Optoacoustic imaging system having handheld probe utilizing optically reflective material
US11191435B2 (en) 2013-01-22 2021-12-07 Seno Medical Instruments, Inc. Probe with optoacoustic isolator
US20130338475A1 (en) 2012-06-13 2013-12-19 Seno Medical Instruments, Inc. Optoacoustic imaging system with fiber optic cable
US9743839B2 (en) 2011-11-02 2017-08-29 Seno Medical Instruments, Inc. Playback mode in an optoacoustic imaging system
US9814394B2 (en) 2011-11-02 2017-11-14 Seno Medical Instruments, Inc. Noise suppression in an optoacoustic system
US9445786B2 (en) 2011-11-02 2016-09-20 Seno Medical Instruments, Inc. Interframe energy normalization in an optoacoustic imaging system
US20130289381A1 (en) 2011-11-02 2013-10-31 Seno Medical Instruments, Inc. Dual modality imaging system for coregistered functional and anatomical mapping
US20130116538A1 (en) 2011-11-02 2013-05-09 Seno Medical Instruments, Inc. Optoacoustic imaging systems and methods with enhanced safety
US9733119B2 (en) 2011-11-02 2017-08-15 Seno Medical Instruments, Inc. Optoacoustic component utilization tracking
US20140005544A1 (en) 2011-11-02 2014-01-02 Seno Medical Instruments, Inc. System and method for providing selective channel sensitivity in an optoacoustic imaging system
US11287309B2 (en) 2011-11-02 2022-03-29 Seno Medical Instruments, Inc. Optoacoustic component utilization tracking
JP5936330B2 (en) 2011-11-04 2016-06-22 キヤノン株式会社 Acoustic wave measuring device and control method of acoustic wave measuring device
US8886294B2 (en) 2011-11-30 2014-11-11 Covidien Lp Methods and systems for photoacoustic monitoring using indicator dilution
US9186068B2 (en) 2011-12-05 2015-11-17 Covidien Lp Methods and systems for photoacoustic monitoring using hypertonic and isotonic indicator dilutions
US9131852B2 (en) 2011-12-05 2015-09-15 Covidien Lp Methods and systems for photoacoustic monitoring using indicator dilution
JP6148257B2 (en) * 2012-01-23 2017-06-14 トモウェーブ ラボラトリーズ，インク． Laser photoacoustic ultrasonic imaging system (Louis) and method of use
CA2866840C (en) 2012-03-09 2022-03-29 Seno Medical Instruments, Inc. Statistical mapping in an optoacoustic imaging system
US9629528B2 (en) 2012-03-30 2017-04-25 The General Hospital Corporation Imaging system, method and distal attachment for multidirectional field of view endoscopy
US9833146B2 (en) 2012-04-17 2017-12-05 Covidien Lp Surgical system and method of use of the same
US8885155B2 (en) 2012-04-30 2014-11-11 Covidien Lp Combined light source photoacoustic system
KR101974580B1 (en) 2012-05-03 2019-05-02 삼성전자주식회사 The laser-induced ultrasonic wave apparatus and the method of generating a image using the same
WO2013177154A1 (en) 2012-05-21 2013-11-28 The General Hospital Corporation Apparatus, device and method for capsule microscopy
JP5984547B2 (en) 2012-07-17 2016-09-06 キヤノン株式会社 Subject information acquisition apparatus and control method thereof
JP6227652B2 (en) 2012-08-22 2017-11-08 ザ ジェネラル ホスピタル コーポレイション System, method, and computer-accessible medium for fabricating a miniature endoscope using soft lithography
US11020006B2 (en) 2012-10-18 2021-06-01 California Institute Of Technology Transcranial photoacoustic/thermoacoustic tomography brain imaging informed by adjunct image data
JP6080485B2 (en) * 2012-10-18 2017-02-15 キヤノン株式会社 SUBJECT INFORMATION ACQUISITION DEVICE AND METHOD FOR CONTROLLING SUBJECT INFORMATION ACQUISITION DEVICE
EP2742854B1 (en) 2012-12-11 2021-03-10 iThera Medical GmbH Handheld device and method for tomographic optoacoustic imaging of an object
DE102012223651A1 (en) * 2012-12-18 2014-06-18 Carl Zeiss Ag A resection imaging method and apparatus for performing such an imaging method
JP6112861B2 (en) 2012-12-28 2017-04-12 キヤノン株式会社 SUBJECT INFORMATION ACQUISITION DEVICE, SIGNAL PROCESSING DEVICE, AND DISPLAY DEVICE
EP2754388B1 (en) 2013-01-15 2020-09-09 Helmholtz Zentrum München Deutsches Forschungszentrum für Gesundheit und Umwelt GmbH System and method for quality-enhanced high-rate optoacoustic imaging of an object
JP6192297B2 (en) 2013-01-16 2017-09-06 キヤノン株式会社 SUBJECT INFORMATION ACQUISITION DEVICE, DISPLAY CONTROL METHOD, AND PROGRAM
WO2014120791A1 (en) 2013-01-29 2014-08-07 The General Hospital Corporation Apparatus, systems and methods for providing information regarding the aortic valve
WO2014121082A1 (en) 2013-02-01 2014-08-07 The General Hospital Corporation Objective lens arrangement for confocal endomicroscopy
US9380981B2 (en) 2013-03-15 2016-07-05 Covidien Lp Photoacoustic monitoring technique with noise reduction
SG11201506836YA (en) 2013-03-15 2015-09-29 Seno Medical Instr Inc System and method for diagnostic vector classification support
EP2967491B1 (en) 2013-03-15 2022-05-11 The General Hospital Corporation A transesophageal endoscopic system for determining a mixed venous oxygen saturation of a pulmonary artery
JP5575293B2 (en) * 2013-03-22 2014-08-20 キヤノン株式会社 Subject information acquisition apparatus and subject information acquisition method
WO2014176132A1 (en) * 2013-04-22 2014-10-30 The Curators Of The University Of Missouri Photoacoustic probe for burn injury diagnosis
WO2014186353A1 (en) 2013-05-13 2014-11-20 The General Hospital Corporation Detecting self-interefering fluorescence phase and amplitude
WO2015009932A1 (en) 2013-07-19 2015-01-22 The General Hospital Corporation Imaging apparatus and method which utilizes multidirectional field of view endoscopy
EP3021735A4 (en) 2013-07-19 2017-04-19 The General Hospital Corporation Determining eye motion by imaging retina. with feedback
ES2893237T3 (en) 2013-07-26 2022-02-08 Massachusetts Gen Hospital Apparatus with a laser arrangement using optical scattering for applications in optical coherence tomography in the Fourier domain
WO2015054688A2 (en) 2013-10-11 2015-04-16 Seno Medical Instruments, Inc. Systems and methods for component separation in medical imaging
US11137375B2 (en) 2013-11-19 2021-10-05 California Institute Of Technology Systems and methods of grueneisen-relaxation photoacoustic microscopy and photoacoustic wavefront shaping
EP3071094A1 (en) 2013-11-22 2016-09-28 Massachusetts Institute Of Technology System and method for non-contact ultrasound
US9733460B2 (en) 2014-01-08 2017-08-15 The General Hospital Corporation Method and apparatus for microscopic imaging
WO2015116986A2 (en) 2014-01-31 2015-08-06 The General Hospital Corporation System and method for facilitating manual and/or automatic volumetric imaging with real-time tension or force feedback using a tethered imaging device
WO2015117070A1 (en) 2014-01-31 2015-08-06 Tomowave Laboratories, Inc. Optoacoustic image mapping of tissue temperature
US10258241B2 (en) 2014-02-27 2019-04-16 Seno Medical Instruments, Inc. Probe adapted to control blood flow through vessels during imaging and method of use of same
TWI662540B (en) 2014-03-12 2019-06-11 美商富士膠片索諾聲公司 High frequency ultrasound transducer having an ultrasonic lens with integral central matching layer
WO2015153982A1 (en) 2014-04-04 2015-10-08 The General Hospital Corporation Apparatus and method for controlling propagation and/or transmission of electromagnetic radiation in flexible waveguide(s)
US10238369B2 (en) 2014-06-10 2019-03-26 The Johns Hopkins University Real time ultrasound thermal dose monitoring system for tumor ablation therapy
AU2015287867B2 (en) 2014-07-08 2019-04-11 Noninvasix, Inc. Systems and methods for measuring fetal cerebral oxygenation
EP3171766B1 (en) 2014-07-25 2021-12-29 The General Hospital Corporation Apparatus for in vivo imaging and diagnosis
EP3212065B1 (en) 2014-10-30 2022-03-30 Seno Medical Instruments, Inc. Opto-acoustic imaging system with detection of relative orientation of light source and acoustic receiver using acoustic waves
AU2016233575A1 (en) 2015-03-14 2017-07-13 The Board Of Regents Of The University Of Texas System Systems and methods for measuring neonatal cerebral oxygenation
US10028662B2 (en) 2015-05-14 2018-07-24 Endra Life Sciences Inc. Systems and methods for imaging biological tissue structures
US10898166B2 (en) 2015-05-14 2021-01-26 Endra Life Sciences Inc. Systems and methods for imaging biological tissue structures
WO2017160858A1 (en) 2016-03-14 2017-09-21 Massachusetts Institute Of Technology System and method for non-contact ultrasound with enhanced safety
WO2018209046A1 (en) 2017-05-10 2018-11-15 Washington University Snapshot photoacoustic photography using an ergodic relay
NL2019124B1 (en) 2017-06-27 2019-01-07 Sigmascreening B V Mammography apparatus
NL2019834B1 (en) 2017-10-31 2019-05-08 Sigmascreening B V Mammography apparatus and method of pressurizing a breast
US10806513B2 (en) * 2018-01-16 2020-10-20 Bin Rao Methods and apparatus for optimizing selective photothermolysis
WO2019152045A1 (en) * 2018-02-02 2019-08-08 Xinova, LLC Real-time treatment adjustment based on dosimetric data
JP7458078B2 (en) 2018-03-09 2024-03-29 テヒニッシェ ウニヴェルジテート ミュンヘン Tissue measurement sensor
US10799292B2 (en) * 2018-05-04 2020-10-13 Bin Rao High power tunable optical parametric oscillator for selective photothermolysis laser surgeries
IL261039B (en) 2018-08-07 2020-10-29 Elbit Systems Land & C4I Ltd Two-stage photo-acoustic excitation sensing systems and methods
WO2020037082A1 (en) 2018-08-14 2020-02-20 California Institute Of Technology Multifocal photoacoustic microscopy through an ergodic relay
EP3847453A4 (en) 2018-09-04 2022-06-22 California Institute of Technology Enhanced-resolution infrared photoacoustic microscopy and spectroscopy
US11369280B2 (en) 2019-03-01 2022-06-28 California Institute Of Technology Velocity-matched ultrasonic tagging in photoacoustic flowgraphy
US11701035B2 (en) 2019-10-28 2023-07-18 Bruce M. Landy Noninvasive blood glucose detector and method using IR
US20220022960A1 (en) * 2020-07-21 2022-01-27 Gyrus Acmi, Inc. D/B/A Olympus Surgical Technologies America Laser treatment using acoustic feedback
CN114469010A (en) * 2022-04-19 2022-05-13 常州英诺激光科技有限公司 Photoacoustic blood oxygen measuring device and method based on laser energy compensation technology

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4028933A (en) * 1974-02-15 1977-06-14 The Board Of Trustees Of Leland Stanford Junior University Acoustic microscope
FR2405485A1 (en) * 1977-10-07 1979-05-04 Thomson Csf ULTRASONIC VISUALIZATION SYSTEM OF A THIN SECTION OF A BODY
US4430897A (en) * 1981-05-14 1984-02-14 The Board Of Trustees Of The Leland Stanford University Acoustic microscope and method
US4727420A (en) * 1984-10-16 1988-02-23 Fuji Photo Film Co., Ltd. Acoustooptic image formation
US4710030A (en) * 1985-05-17 1987-12-01 Bw Brown University Research Foundation Optical generator and detector of stress pulses
NO880891L (en) * 1987-03-03 1988-09-05 Elizabeth May Dowling PROCEDURE AND APPARATUS FOR MEASURING OR DETECTING THE CONCENTRATION OF A SUBSTANCE.
WO1989007753A1 (en) * 1988-02-19 1989-08-24 Koch High Tech Ag Ultrasonic temperature measurement and applications in optical spectroscopy and calorimetry
JP2685482B2 (en) * 1988-04-08 1997-12-03 株式会社日立製作所 Method and apparatus for analyzing particulate matter
DE3842916C1 (en) * 1988-12-21 1990-02-01 Messerschmitt-Boelkow-Blohm Gmbh, 8012 Ottobrunn, De
US4950897A (en) * 1989-01-04 1990-08-21 University Of Toronto Innovations Foundation Thermal wave sub-surface defect imaging and tomography apparatus
US5421337A (en) * 1989-04-14 1995-06-06 Massachusetts Institute Of Technology Spectral diagnosis of diseased tissue
US5136172A (en) * 1989-08-16 1992-08-04 Hitachi, Ltd. Method and apparatus for detecting photoacoustic signal
US5254112A (en) * 1990-10-29 1993-10-19 C. R. Bard, Inc. Device for use in laser angioplasty
DE4128744C1 (en) * 1991-08-29 1993-04-22 Siemens Ag, 8000 Muenchen, De
US5269309A (en) * 1991-12-11 1993-12-14 Fort J Robert Synthetic aperture ultrasound imaging system
US5398685A (en) * 1992-01-10 1995-03-21 Wilk; Peter J. Endoscopic diagnostic system and associated method
FR2712697B1 (en) * 1993-11-19 1995-12-15 Commissariat Energie Atomique Elementary analysis method by optical emission spectrometry on plasma produced by laser in the presence of argon.
DE4400674C2 (en) * 1994-01-12 1995-10-26 Siemens Ag Photoacoustic sensor
US5602894A (en) * 1994-08-04 1997-02-11 Bardash; Michael J. Three-dimensional imaging system using laser generated ultrashort x-ray pulses
FR2728452B1 (en) * 1994-12-22 1997-07-25 Dior Christian Parfums DEVICE FOR PHOTOACOUSTIC ANALYSIS OF SKIN IN SITU
US5582578A (en) * 1995-08-01 1996-12-10 Duke University Method for the comminution of concretions
US5615675A (en) * 1996-04-19 1997-04-01 Regents Of The University Of Michigan Method and system for 3-D acoustic microscopy using short pulse excitation and 3-D acoustic microscope for use therein

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