CA2300054C - Foam skin cream, uses of the foam skin protection cream and a process for its preparation - Google Patents
Foam skin cream, uses of the foam skin protection cream and a process for its preparation Download PDFInfo
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- CA2300054C CA2300054C CA002300054A CA2300054A CA2300054C CA 2300054 C CA2300054 C CA 2300054C CA 002300054 A CA002300054 A CA 002300054A CA 2300054 A CA2300054 A CA 2300054A CA 2300054 C CA2300054 C CA 2300054C
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- skin cream
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/361—Carboxylic acids having more than seven carbon atoms in an unbroken chain; Salts or anhydrides thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
- A61K8/04—Dispersions; Emulsions
- A61K8/046—Aerosols; Foams
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
- A61K8/342—Alcohols having more than seven atoms in an unbroken chain
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/55—Phosphorus compounds
- A61K8/556—Derivatives containing from 2 to 10 oxyalkylene groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
- A61K8/9783—Angiosperms [Magnoliophyta]
- A61K8/9789—Magnoliopsida [dicotyledons]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q17/00—Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
Abstract
A foam skin cream can be obtained by - preparing a phase I by melting at 75 .degree.C a mixture containing fatty acids, especially C12-C22 fatty acids, optionally unsaturated and/or polyunsaturated fatty acids, emulsifiers, coemulsifiers, such as triceteareth-4-phosphate, followed by metering it with stirring to - a phase II temperature-controlled at 75 .degree.C obtained from an aqueous mixture containing moisturizers, such as propylene glycol and/or polyhydric alcohols, especially glycerol, emulsifiers, such as alkyl sar- cosinates, and skin care additives, such as allantoin; - wherein homogeneous mixing of phases I and II is provided and said metering is performed at a temperature of 75 .degree.C; - after the metered addition, the temperature is maintained at 75 .degree.C for a period of between 5 and 20 minutes; whereupon - the temperature of the thus obtained mixture is lowered to a tem- perature of between 30 and 40 .degree.C with constant stirring; - the pH value is adjusted to from 7.6 to 8.2, preferably with a skin- compatible basic organic compound, and the mixture obtained is filled into dosage forms with the addition of a propellant.
Description
SMB
Foam Skin Cream, Uses of the Foam Skin Protection Cream and a Process for Its Pre~~aration The present invention relates to a foam skin cream, uses of the foam skin protection cream and a process for its preparation.
The galenic principle of an emulsoid two-phase system having lipophilic or hydrophobic components and, on the other hand, hydrophilic components has been known for the production of foam preparations for skin care. The application of these foam preparations to the treated skin forms a two-dimensional two-phase network, the hydrophilic components bind to the keratin of the horny layer and enable the evaporation of sweat while the lipophilic components inhibit the permeation of moisture (including the penetrated sweat) on the skin surface. As the foam, in contrast to other creams building a barrier, is absorbed in less than a minute, does not leave any grease traces on the working materials and prevents heat built-up or even maceration effects from the action of sweat, the foam has enjoyed rapidly growing popularity as a protective agent against occupational action of moisture. Further details about the per se known foam skin creams can be seen, in particular, from "Haut", issue 4, 1992, by R. Rudolph, L.' Bade, B. Bruggemann.
In "hautnah derm" 10 (1994), 344-351, B. Kunze reports lipid-containing skin protection foams which are indicated for dry sensitive skin and chroni-cal-rhagadiform eczemas. Ingredients are also disclosed therein. The skin protection foams described therein are protective against a lot of occupa-tional noxious matters, such as acid permanent waving liquids in the hairdresser's trade, lyes, oils, disinfectants, cleaning and rinsing agents, but also against water, moisture, sweat, feces, urine and mineral dusts.
-2_ EP 0 598 412 also relates to skin protection foams; PTFE is described as an active principle.
DE-C-33 30 628 relates to skin protection and care lotions containing silicone oils, partially neutralized stearic acid, fatty alcohols and their ethoxylated derivatives, ethoxylated wool alcohols, cetyl/stearyl alcohol, vaseline, thickeners and water. The lotions disclosed therein are said to be quickly absorbed without leaving an annoying grease film on the skin for extended periods of time.
Information about emulsifiers which can be employed in skin care agents are found in DE-A-195 42 572. This reference suggests emulsifiers which contain from 43 to 90% by weight of alkyl and/or alkenyl oligoglycosides and from 10 to 57% by weight of fatty alcohols. These emulsifiers are particularly suitable for the preparation of highly viscous, sensorily light oil-in-water emulsions having a long shelf life. The German utility model DE-U-9308050 relates to a skin protection foam used against skin-aggressive agents. This foam consists of an aqueous emulsion containing fatty acid esters with good skin compatibility for the production of a moisture-per-meable film, polyhydric alcohol for stably dispersing the active agents and controlling the humidity of the film, emulsifiers for improving foam stability, surfactants for reducing the surface tension and optionally neutralizing agents for resins and emulsifiers. Gaseous hydrocarbons may be used as propellants, for example, propane, butane or isobutane and mixtures thereof. However, the foams described do not contain any free fatty acids.
Aerosoles are complicated physical-chemical structures which do not form under arbitrary circumstances. In Particular, a special balance between the foam-forming components is important. Slight shifts in the composition may already result in a collapse of the foam; thus, a formulation of per se active substances may not be capable of being formulated as a foam without further provisions.
Especially in occupational applications, skin creams are often found un-pleasant because the "fatting" components remain too long on the skin and lead to annoying finger traces or generally to an unpleasant feeling. This has been remedied to some extent by the per se known skin foams since they help preventing or reducing overload of the skin with the fatting matters.
Nevertheless, it is desirable to find even more acceptance by the user, especially in the long-term use of skin protection agents.
The present invention seeks to extend the application range of skin protection foams by providing a formulation which is highly accepted by the user, the admixture of a wide variety of other substances being allowed without destroying the aerosol employed or deteriorating the properties of the aerosol.
This has surprisingly been achieved by a base formulation of a foam skin cream of the invention. The invention also relates to use of the foam skin cream according to the invention, and to a process for preparing the base of a foam skin cream according to the invention.
The foam skin cream according to the invention can be obtained by - preparing a phase I by melting at 75 °C a mixture containing fatty acids, especially C12-Caa fatty acids, optionally unsaturated and/or polyunsaturated fatty acids, emulsifiers, coemulsifiers, such as triceteareth-4-phosphate, followed by metering it with stirring to a phase II temperature-controlled at 75°C obtained from an aqueous mixture containing moisturizers, such as propylene glycol and/or polyhydric alcohols, especially glycerol, emulsifiers, such as alkyl sarcosinates, and skin care additives, such as allantoin;
- wherein homogeneous mixing of phases I and II is provided and said metering is performed at a temperature of 75°C;
- after the metered addition, the temperature is maintained at 75°C
for a period of between 5 and 20 minutes; whereupon - the temperature of the thus obtained mixture is lowered to a tem-perature of between 30 and 40 °C with constant stirring;
- the pH value is adjusted to from 7.6 to 8.2, preferably with a skin-compatible basic organic compound, and the mixture obtained is filled into dosage forms with the addition of a propellant.
At the one hand, the product obtainable according to this process can be directly employed as a foam skin cream in the industrial field for the protection from or reduction of the absorption of cancerogenic substances, such as polycyclic aromatic hydrocarbons. This mixture is capable of providing effective protection for persons whose skin has already been exposed to cancerogenic substances, such as polycyclic aromatic hydrocar-bons. In addition, the mixture is suitable for providing protection to persons from the action of acids, lyes (not above pH 11), scouring agents and detergents, sweat, urine, stool, rubber gloves, dusts, house dust, machine, drilling and cooling oils, greases, paints/varnishes, gypsum and other substances and chemicals, especially aggressive substances and chemicals.
The foam skin cream according to the invention contains fatty acids, especially C12-Czz fatty acids, and may optionally additionally contain unsaturated and/or polyunsaturated fatty acids. Useful fatty acids which are saturated include, in particular, the naturally occurring C12-C22 fatty acids, especially stearic acid and palmitic acid. Myristic acid may also be used.
Useful unsaturated fatty acids include, in particular, those having up to three unsaturated bonds in their hydrocarbon chain. Unsaturated fatty acids are found, for example, in fractions of coconut fat. Useful coemulsifiers include per se known coemulsifiers, especially triceteareth-4-phosphate, sodium laureth-4-phosphate or oleth-3 and other lipophilic emulsifiers based on fatty alcohols with a low degree of ethoxylation.
Phase I may additionally contain paraffinum liquidum. Emulsifiers to be used in phase I may include those based on fatty alcohols and those based on partial esters of fatty acids. Particularly preferred fatty alcohols include cetearyl alcohol. Glyceryl stearate, for example, may be employed as a partial ester of a fatty acid.
The moisturizers to be used in phase II include, in particular, propylene glycol andlor polyhydric alcohols, such as glycerol. As particular emulsifiers to be used in phase II, there may be mentioned alkyl sarcosinates, such as lauroyl, lauryl, cetyl sarcosinates.
The mixture obtainable also serves as a base for other foam skin creams which may be employed in a wide range of applications for protecting the skin and alleviating dermatological dysfunctions.
If desired, one or more preservatives may be added to the foam skin cream according to the invention. In particular, substances such as methyldibromo-glutaronitrile and/or phenoxyethanol have proven to be suitable pre-preservatives. These substances may be added in amounts of from 0.01 to 1% by weight.
Preferably, the emulsifiers, fatty acids, coemulsifiers, moisturizers and skin care agents, especially allantoin, panthenol etc., are used in the following amounts:
from 4 to 15% by weight of oil-in-water emulsifier;
from 1 to 10% by weight of fatty acid, especially from 4 to 7% by weight, preferably from 4.5 to 6% by weight.
from 0.4 to 2.3% by weight of coemulsifier;
from 1 to 10% by weight of moisturizer;
from 0.05 to 1 % by weight of skin care agent; and water as the balance to make 100% by weight.
A preferable foam skin cream according to the invention contains:
from 1 to 3% by weight of glyceryl stearate;
from 3 to 6% by weight of cetearyl alcohol;
from 4 to 6% by weight of stearic acid;
from 0.5 to 2% by weight of paraffin;
from 0.4 to 2.3% by weight of triceteareth-4-phosphate;
from 1.5 to 4% by weight of propylene glycol;
from 1.3 to 4.2% by weight of glycerol;
from 1 to 3% by weight of cetyl sarcosinate;
from 0.05 to 1% by weight of allantoin; and water as the balance to make 100% by weight.
In another preferred embodiment, the foam skin cream according to the invention additionally contains a silicone-containing substance, such as dimethicone. This substance is added to phase I. Preferably, it is present in amounts of from 0.05 to 1% by weight.
In addition, the foam skin cream according to the invention may addition-ally contain one or more refitting substances in phase I, such as decyl oleate, isohexadecane, stearic acid glycol ester, coconut fatty acid ethanol-amide, corn oil, peanut oil, almond oil, sesame oil, olive oil, jojoba oil, soybean oil, wool wax alcohols, paraffin, medium-chain triglycerides, oleic acid oleyl esters, white petrolatum, macrogol-glycerol hydroxystearate, hydrogenated castor oil, castor oil from Ricinus communis, avocado oil, wheat germ oil, palmitic acid isopropyl ester, cetyl palmitate, myristic acid myristyl ester and/or octyldodecanol.
In particular, the foam skin cream contains amounts of from 0.5 to 2% by weight of decyl oleate and/or from 0.5 to 2% by weight of octyldecanol, or another of the refitting substances mentioned, if the product is to be used for normal skin. The total amount of refitting substances is to be such that the skin protection foam is not destroyed. An amount of about 4% by weight of refitting substances is sufficient for normal to slightly dry skin.
If dry skin is to be treated with the foam skin cream according to the inven-tion, amounts of from 3 to 6% by weight of a component of the refitting substances, such as, in particular, decyl oleate and/or octyldecanol, are recommendable. If more than one component is used, the total amount of refitting components is to be about 12% at most for slightly dry skin. If even more severely dry skin is treated, the amount of refitting substances is from about 6 to 9% by weight if a component such as decyl oleate is used, and from 6 to 9% by weight if octyldecanol is used. The amount of refitting substance may then be up to 20% by weight.
- 7 _ Like the products without silicone-containing substances, the latter foam skin creams are suitable for the care and protection of the skin, especially from aggressive substances, such as scouring agents and detergents, sweat, urine, stool, rubber gloves, dusts, house dust, machine, drilling and cooling oils, greases, paints/varnishes, gypsum and other substances and chemicals, especially aggressive substances and chemicals.
The foam skin creams are also suitable for the treatment or alleviation of dermatological diseases. This includes, in particular, dermatological dis-eases such as allergic contact dermatitis type I and IV, cumulative-subtoxic eczema, toxic-irritative eczema, microbial-dysregulative eczema, atopic dermatitis, atopic palmoplantar eczema, dyshidrosis, hyperhidrosis, contact urticaria, intertriginous eczema in connection with hemorrhoids, various weeping fungal infections, e.g., interdigital mycosis, perleches, psoriasis vulgaris, ulcus cruris, cholinergic urticaria, diaper dermatitis.
It may be indicated to include substances which can increase the moisture content of the skin, in addition to refitting substances. Such hydratizing substances include, in particular, urea, ethoxydiglycol, sodium chloride, magnesium chloride, sorbitol, dexpanthenol, sodium lactate, allantoin, hyaluronic acid, vitamin E, linolenic acid. The amount of those substances can be from 1 to 20% by weight or more of the respective substances, depending on the severity of the disease to be treated. These quantities also apply, in particular, to urea which may also be present in amounts of from 3 to 15% by weight or from 12.5 to 15% by weight. The foam skin cream according to the invention may also be used for psoriasis.
One particularly important field of application concerns the prophylaxis and treatment of diabetic foot. Due to accompanying symptoms of diabetes, diabetics suffer from dry skin which in the course of the diseases favors damage to the extremities, up to an extent where amputation becomes necessary in the case of those having been diabetic for many years. Pro-phylactic application of skin protection agents which provide an improve-ment of the skin parameters in diabetics can prevent the development of diabetic foot.
- $ -In addition, skin care substances, such as polyunsaturated fatty acids (PUFA), may be added to the foam skin cream according to the invention.
These include, in particular, omega-6 fatty acids as known, for example, from evening primrose oil and borage oil. Both synthetic omega-6 fatty acids and those obtained from the mentioned plant extracts may be employed.
Further, there may be used soothing substances, such as chamomile extract, as another fraction which may be admixed with the foam skin cream according to the invention.
Skin-active vitamins, such as vitamins A, E and F, may be admixed with the foam skin cream according to the invention in effective amounts. Especially for the treatment and prevention of diaper dermatitis, admixing the follow-ing substances has proven useful: from 3 to 7% by weight of Calendula extract, from 3 to 7% by weight of Hamamelis extract, from 3 to 7% by weight of chamomile extract, from 3 to 7% by weight of tea tree oil extract, from 1 to 5% by weight of decyl oleate, from 1 to 5% by weight of octyldo-decanol.
The process according to the invention for the preparation of the foam skin protection cream according to the invention comprises the following steps:
preparing a phase I by melting at 75 °C a mixture containing fatty acids, especially C12-C22 fatty acids, optionally unsaturated and/or polyunsaturated fatty acids, coemulsifiers, such as triceteareth-4-phosphate, followed by metering this phase with stirring to - a phase II molten at 75 °C obtained from an aqueous mixture containing moisturizers, such as propylene glycol and/or polyhydric alcohols, especially glycerol, emulsifiers, such as alkyl sarcosinates, and skin care additives, such as allantoin;
- wherein homogeneous mixing of phases I and II is provided and said metering is performed at a temperature of 75 °C;
_g_ - after the addition of phase I to phase II, the temperature is main-tained at 75 °C for a period of between 5 and 20 minutes; whereupon - the temperature of the thus obtained mixture is lowered to a tem-perature of between 30 and 40 °C with constant stirring;
- adjusting the pH value to from 7.6 to 8.2, preferably with a skin-compatible basic organic compound, and filling into containers with the addition of a propellant.
The invention will be further illustrated by the following Example.
Examl I~e The skin protection cream according to the invention is prepared in a heatable and coolable closed apparatus with a self-withdrawing homogeni-sator and a heatable metering funnel (preferably in a Koruma multipurpose apparatus).
The preparation of phase I is effected in a heatable metering funnel by melting at 75 °C a mixture containing 2% by weight of glyceryl stearate, 4% by weight of cetearyl alcohol, 5% by weight of stearic acid, 1% by weight of paraffin and 1% by weight of triceteareth-4-phosphate, followed by metering this phase with stirring to phase II previously prepared in the heatable and coolable closed apparatus with a self-withdrawing homogeni-sator. Phase II consists of an aqueous mixture containing 2.5% by weight of propylene glycol, 2.5% by weight of glycerol, 2% by weight of sodium lauroylsarcosinate and 0.3% by weight of allantoin. The amount of water is 79.7% by weight. Homogeneous mixing of phases I and II is to be pro-vided.
The metering of phase I is performed at a temperature of 75 °C.
Both phases are combined with constant stirring at a medium stirring speed; and care must be taken that homogenization is effected uniformly. The tem-perature is maintained at 75 °C for between 5 and 20 min. The mixture obtained is cooled to a temperature of between 30 and 40 °C with constant stirring.
Then, after a temperature of 40 °C has been reached, the further sub-stances may be added. This may include adjusting the pH value to between 7.8 and 8Ø For this purpose, 2-amino-2-methyl-1-propanol is used.
Stirring is continued for a sufficient period of time until the pH value has stabilized, followed by filling into suitable storage tanks or into the corre-sponding spraying containers. In the latter case, 91% of drug is filled together with 9% of butane/propane.
Foam Skin Cream, Uses of the Foam Skin Protection Cream and a Process for Its Pre~~aration The present invention relates to a foam skin cream, uses of the foam skin protection cream and a process for its preparation.
The galenic principle of an emulsoid two-phase system having lipophilic or hydrophobic components and, on the other hand, hydrophilic components has been known for the production of foam preparations for skin care. The application of these foam preparations to the treated skin forms a two-dimensional two-phase network, the hydrophilic components bind to the keratin of the horny layer and enable the evaporation of sweat while the lipophilic components inhibit the permeation of moisture (including the penetrated sweat) on the skin surface. As the foam, in contrast to other creams building a barrier, is absorbed in less than a minute, does not leave any grease traces on the working materials and prevents heat built-up or even maceration effects from the action of sweat, the foam has enjoyed rapidly growing popularity as a protective agent against occupational action of moisture. Further details about the per se known foam skin creams can be seen, in particular, from "Haut", issue 4, 1992, by R. Rudolph, L.' Bade, B. Bruggemann.
In "hautnah derm" 10 (1994), 344-351, B. Kunze reports lipid-containing skin protection foams which are indicated for dry sensitive skin and chroni-cal-rhagadiform eczemas. Ingredients are also disclosed therein. The skin protection foams described therein are protective against a lot of occupa-tional noxious matters, such as acid permanent waving liquids in the hairdresser's trade, lyes, oils, disinfectants, cleaning and rinsing agents, but also against water, moisture, sweat, feces, urine and mineral dusts.
-2_ EP 0 598 412 also relates to skin protection foams; PTFE is described as an active principle.
DE-C-33 30 628 relates to skin protection and care lotions containing silicone oils, partially neutralized stearic acid, fatty alcohols and their ethoxylated derivatives, ethoxylated wool alcohols, cetyl/stearyl alcohol, vaseline, thickeners and water. The lotions disclosed therein are said to be quickly absorbed without leaving an annoying grease film on the skin for extended periods of time.
Information about emulsifiers which can be employed in skin care agents are found in DE-A-195 42 572. This reference suggests emulsifiers which contain from 43 to 90% by weight of alkyl and/or alkenyl oligoglycosides and from 10 to 57% by weight of fatty alcohols. These emulsifiers are particularly suitable for the preparation of highly viscous, sensorily light oil-in-water emulsions having a long shelf life. The German utility model DE-U-9308050 relates to a skin protection foam used against skin-aggressive agents. This foam consists of an aqueous emulsion containing fatty acid esters with good skin compatibility for the production of a moisture-per-meable film, polyhydric alcohol for stably dispersing the active agents and controlling the humidity of the film, emulsifiers for improving foam stability, surfactants for reducing the surface tension and optionally neutralizing agents for resins and emulsifiers. Gaseous hydrocarbons may be used as propellants, for example, propane, butane or isobutane and mixtures thereof. However, the foams described do not contain any free fatty acids.
Aerosoles are complicated physical-chemical structures which do not form under arbitrary circumstances. In Particular, a special balance between the foam-forming components is important. Slight shifts in the composition may already result in a collapse of the foam; thus, a formulation of per se active substances may not be capable of being formulated as a foam without further provisions.
Especially in occupational applications, skin creams are often found un-pleasant because the "fatting" components remain too long on the skin and lead to annoying finger traces or generally to an unpleasant feeling. This has been remedied to some extent by the per se known skin foams since they help preventing or reducing overload of the skin with the fatting matters.
Nevertheless, it is desirable to find even more acceptance by the user, especially in the long-term use of skin protection agents.
The present invention seeks to extend the application range of skin protection foams by providing a formulation which is highly accepted by the user, the admixture of a wide variety of other substances being allowed without destroying the aerosol employed or deteriorating the properties of the aerosol.
This has surprisingly been achieved by a base formulation of a foam skin cream of the invention. The invention also relates to use of the foam skin cream according to the invention, and to a process for preparing the base of a foam skin cream according to the invention.
The foam skin cream according to the invention can be obtained by - preparing a phase I by melting at 75 °C a mixture containing fatty acids, especially C12-Caa fatty acids, optionally unsaturated and/or polyunsaturated fatty acids, emulsifiers, coemulsifiers, such as triceteareth-4-phosphate, followed by metering it with stirring to a phase II temperature-controlled at 75°C obtained from an aqueous mixture containing moisturizers, such as propylene glycol and/or polyhydric alcohols, especially glycerol, emulsifiers, such as alkyl sarcosinates, and skin care additives, such as allantoin;
- wherein homogeneous mixing of phases I and II is provided and said metering is performed at a temperature of 75°C;
- after the metered addition, the temperature is maintained at 75°C
for a period of between 5 and 20 minutes; whereupon - the temperature of the thus obtained mixture is lowered to a tem-perature of between 30 and 40 °C with constant stirring;
- the pH value is adjusted to from 7.6 to 8.2, preferably with a skin-compatible basic organic compound, and the mixture obtained is filled into dosage forms with the addition of a propellant.
At the one hand, the product obtainable according to this process can be directly employed as a foam skin cream in the industrial field for the protection from or reduction of the absorption of cancerogenic substances, such as polycyclic aromatic hydrocarbons. This mixture is capable of providing effective protection for persons whose skin has already been exposed to cancerogenic substances, such as polycyclic aromatic hydrocar-bons. In addition, the mixture is suitable for providing protection to persons from the action of acids, lyes (not above pH 11), scouring agents and detergents, sweat, urine, stool, rubber gloves, dusts, house dust, machine, drilling and cooling oils, greases, paints/varnishes, gypsum and other substances and chemicals, especially aggressive substances and chemicals.
The foam skin cream according to the invention contains fatty acids, especially C12-Czz fatty acids, and may optionally additionally contain unsaturated and/or polyunsaturated fatty acids. Useful fatty acids which are saturated include, in particular, the naturally occurring C12-C22 fatty acids, especially stearic acid and palmitic acid. Myristic acid may also be used.
Useful unsaturated fatty acids include, in particular, those having up to three unsaturated bonds in their hydrocarbon chain. Unsaturated fatty acids are found, for example, in fractions of coconut fat. Useful coemulsifiers include per se known coemulsifiers, especially triceteareth-4-phosphate, sodium laureth-4-phosphate or oleth-3 and other lipophilic emulsifiers based on fatty alcohols with a low degree of ethoxylation.
Phase I may additionally contain paraffinum liquidum. Emulsifiers to be used in phase I may include those based on fatty alcohols and those based on partial esters of fatty acids. Particularly preferred fatty alcohols include cetearyl alcohol. Glyceryl stearate, for example, may be employed as a partial ester of a fatty acid.
The moisturizers to be used in phase II include, in particular, propylene glycol andlor polyhydric alcohols, such as glycerol. As particular emulsifiers to be used in phase II, there may be mentioned alkyl sarcosinates, such as lauroyl, lauryl, cetyl sarcosinates.
The mixture obtainable also serves as a base for other foam skin creams which may be employed in a wide range of applications for protecting the skin and alleviating dermatological dysfunctions.
If desired, one or more preservatives may be added to the foam skin cream according to the invention. In particular, substances such as methyldibromo-glutaronitrile and/or phenoxyethanol have proven to be suitable pre-preservatives. These substances may be added in amounts of from 0.01 to 1% by weight.
Preferably, the emulsifiers, fatty acids, coemulsifiers, moisturizers and skin care agents, especially allantoin, panthenol etc., are used in the following amounts:
from 4 to 15% by weight of oil-in-water emulsifier;
from 1 to 10% by weight of fatty acid, especially from 4 to 7% by weight, preferably from 4.5 to 6% by weight.
from 0.4 to 2.3% by weight of coemulsifier;
from 1 to 10% by weight of moisturizer;
from 0.05 to 1 % by weight of skin care agent; and water as the balance to make 100% by weight.
A preferable foam skin cream according to the invention contains:
from 1 to 3% by weight of glyceryl stearate;
from 3 to 6% by weight of cetearyl alcohol;
from 4 to 6% by weight of stearic acid;
from 0.5 to 2% by weight of paraffin;
from 0.4 to 2.3% by weight of triceteareth-4-phosphate;
from 1.5 to 4% by weight of propylene glycol;
from 1.3 to 4.2% by weight of glycerol;
from 1 to 3% by weight of cetyl sarcosinate;
from 0.05 to 1% by weight of allantoin; and water as the balance to make 100% by weight.
In another preferred embodiment, the foam skin cream according to the invention additionally contains a silicone-containing substance, such as dimethicone. This substance is added to phase I. Preferably, it is present in amounts of from 0.05 to 1% by weight.
In addition, the foam skin cream according to the invention may addition-ally contain one or more refitting substances in phase I, such as decyl oleate, isohexadecane, stearic acid glycol ester, coconut fatty acid ethanol-amide, corn oil, peanut oil, almond oil, sesame oil, olive oil, jojoba oil, soybean oil, wool wax alcohols, paraffin, medium-chain triglycerides, oleic acid oleyl esters, white petrolatum, macrogol-glycerol hydroxystearate, hydrogenated castor oil, castor oil from Ricinus communis, avocado oil, wheat germ oil, palmitic acid isopropyl ester, cetyl palmitate, myristic acid myristyl ester and/or octyldodecanol.
In particular, the foam skin cream contains amounts of from 0.5 to 2% by weight of decyl oleate and/or from 0.5 to 2% by weight of octyldecanol, or another of the refitting substances mentioned, if the product is to be used for normal skin. The total amount of refitting substances is to be such that the skin protection foam is not destroyed. An amount of about 4% by weight of refitting substances is sufficient for normal to slightly dry skin.
If dry skin is to be treated with the foam skin cream according to the inven-tion, amounts of from 3 to 6% by weight of a component of the refitting substances, such as, in particular, decyl oleate and/or octyldecanol, are recommendable. If more than one component is used, the total amount of refitting components is to be about 12% at most for slightly dry skin. If even more severely dry skin is treated, the amount of refitting substances is from about 6 to 9% by weight if a component such as decyl oleate is used, and from 6 to 9% by weight if octyldecanol is used. The amount of refitting substance may then be up to 20% by weight.
- 7 _ Like the products without silicone-containing substances, the latter foam skin creams are suitable for the care and protection of the skin, especially from aggressive substances, such as scouring agents and detergents, sweat, urine, stool, rubber gloves, dusts, house dust, machine, drilling and cooling oils, greases, paints/varnishes, gypsum and other substances and chemicals, especially aggressive substances and chemicals.
The foam skin creams are also suitable for the treatment or alleviation of dermatological diseases. This includes, in particular, dermatological dis-eases such as allergic contact dermatitis type I and IV, cumulative-subtoxic eczema, toxic-irritative eczema, microbial-dysregulative eczema, atopic dermatitis, atopic palmoplantar eczema, dyshidrosis, hyperhidrosis, contact urticaria, intertriginous eczema in connection with hemorrhoids, various weeping fungal infections, e.g., interdigital mycosis, perleches, psoriasis vulgaris, ulcus cruris, cholinergic urticaria, diaper dermatitis.
It may be indicated to include substances which can increase the moisture content of the skin, in addition to refitting substances. Such hydratizing substances include, in particular, urea, ethoxydiglycol, sodium chloride, magnesium chloride, sorbitol, dexpanthenol, sodium lactate, allantoin, hyaluronic acid, vitamin E, linolenic acid. The amount of those substances can be from 1 to 20% by weight or more of the respective substances, depending on the severity of the disease to be treated. These quantities also apply, in particular, to urea which may also be present in amounts of from 3 to 15% by weight or from 12.5 to 15% by weight. The foam skin cream according to the invention may also be used for psoriasis.
One particularly important field of application concerns the prophylaxis and treatment of diabetic foot. Due to accompanying symptoms of diabetes, diabetics suffer from dry skin which in the course of the diseases favors damage to the extremities, up to an extent where amputation becomes necessary in the case of those having been diabetic for many years. Pro-phylactic application of skin protection agents which provide an improve-ment of the skin parameters in diabetics can prevent the development of diabetic foot.
- $ -In addition, skin care substances, such as polyunsaturated fatty acids (PUFA), may be added to the foam skin cream according to the invention.
These include, in particular, omega-6 fatty acids as known, for example, from evening primrose oil and borage oil. Both synthetic omega-6 fatty acids and those obtained from the mentioned plant extracts may be employed.
Further, there may be used soothing substances, such as chamomile extract, as another fraction which may be admixed with the foam skin cream according to the invention.
Skin-active vitamins, such as vitamins A, E and F, may be admixed with the foam skin cream according to the invention in effective amounts. Especially for the treatment and prevention of diaper dermatitis, admixing the follow-ing substances has proven useful: from 3 to 7% by weight of Calendula extract, from 3 to 7% by weight of Hamamelis extract, from 3 to 7% by weight of chamomile extract, from 3 to 7% by weight of tea tree oil extract, from 1 to 5% by weight of decyl oleate, from 1 to 5% by weight of octyldo-decanol.
The process according to the invention for the preparation of the foam skin protection cream according to the invention comprises the following steps:
preparing a phase I by melting at 75 °C a mixture containing fatty acids, especially C12-C22 fatty acids, optionally unsaturated and/or polyunsaturated fatty acids, coemulsifiers, such as triceteareth-4-phosphate, followed by metering this phase with stirring to - a phase II molten at 75 °C obtained from an aqueous mixture containing moisturizers, such as propylene glycol and/or polyhydric alcohols, especially glycerol, emulsifiers, such as alkyl sarcosinates, and skin care additives, such as allantoin;
- wherein homogeneous mixing of phases I and II is provided and said metering is performed at a temperature of 75 °C;
_g_ - after the addition of phase I to phase II, the temperature is main-tained at 75 °C for a period of between 5 and 20 minutes; whereupon - the temperature of the thus obtained mixture is lowered to a tem-perature of between 30 and 40 °C with constant stirring;
- adjusting the pH value to from 7.6 to 8.2, preferably with a skin-compatible basic organic compound, and filling into containers with the addition of a propellant.
The invention will be further illustrated by the following Example.
Examl I~e The skin protection cream according to the invention is prepared in a heatable and coolable closed apparatus with a self-withdrawing homogeni-sator and a heatable metering funnel (preferably in a Koruma multipurpose apparatus).
The preparation of phase I is effected in a heatable metering funnel by melting at 75 °C a mixture containing 2% by weight of glyceryl stearate, 4% by weight of cetearyl alcohol, 5% by weight of stearic acid, 1% by weight of paraffin and 1% by weight of triceteareth-4-phosphate, followed by metering this phase with stirring to phase II previously prepared in the heatable and coolable closed apparatus with a self-withdrawing homogeni-sator. Phase II consists of an aqueous mixture containing 2.5% by weight of propylene glycol, 2.5% by weight of glycerol, 2% by weight of sodium lauroylsarcosinate and 0.3% by weight of allantoin. The amount of water is 79.7% by weight. Homogeneous mixing of phases I and II is to be pro-vided.
The metering of phase I is performed at a temperature of 75 °C.
Both phases are combined with constant stirring at a medium stirring speed; and care must be taken that homogenization is effected uniformly. The tem-perature is maintained at 75 °C for between 5 and 20 min. The mixture obtained is cooled to a temperature of between 30 and 40 °C with constant stirring.
Then, after a temperature of 40 °C has been reached, the further sub-stances may be added. This may include adjusting the pH value to between 7.8 and 8Ø For this purpose, 2-amino-2-methyl-1-propanol is used.
Stirring is continued for a sufficient period of time until the pH value has stabilized, followed by filling into suitable storage tanks or into the corre-sponding spraying containers. In the latter case, 91% of drug is filled together with 9% of butane/propane.
Claims (41)
1. A foam skin cream, with the exception of a skin cream comprising PTFE, obtainable by - preparing a phase I by melting at 75°C a mixture containing a fatty acid, an emulsifier and a coemulsifier, followed by metering it with stirring to - a phase II temperature-controlled at 75 °C obtained from an aqueous mixture containing at least one of moisturizers, emulsifiers, and skin care additives, -wherein homogeneous mixing of phases I and II is provided and said metering is performed at a temperature of 75 °C;
- after the metered addition, the temperature is maintained at 75 °C
for a period of between 5 and 20 minutes; whereupon - the temperature of the thus obtained mixture is lowered to a temperature of between 30 and 40 °C with constant stirring;
- the pH value is adjusted to from 7.6 to 8.2, and the mixture obtained is filled into dosage forms with the addition of a propellant.
- after the metered addition, the temperature is maintained at 75 °C
for a period of between 5 and 20 minutes; whereupon - the temperature of the thus obtained mixture is lowered to a temperature of between 30 and 40 °C with constant stirring;
- the pH value is adjusted to from 7.6 to 8.2, and the mixture obtained is filled into dosage forms with the addition of a propellant.
2. The foam skin cream according to claim 1, wherein a preservative is added to the mixture of phases I and II with stirring at 30 to 40 °C.
3. The foam skin cream according to claim 1 or 2, containing from 4 to 15%
by weight of oil-in-water emulsifier; from 1 to 10% by weight of fatty acid;
from 0.4 to 2.3% by weight of coemulsifier; from 1 to 10% by weight of moisturizer;
from 0.05 to 1% by weight of skin care agent; and water as the balance to make 100% by weight.
by weight of oil-in-water emulsifier; from 1 to 10% by weight of fatty acid;
from 0.4 to 2.3% by weight of coemulsifier; from 1 to 10% by weight of moisturizer;
from 0.05 to 1% by weight of skin care agent; and water as the balance to make 100% by weight.
4. The foam skin cream according to claim 1, 2 or 3, containing from 1 to 3% by weight of glyceryl stearate; from 3 to 6% by weight of cetearyl alcohol;
from 4 to 6% by weight of stearic acid; from 0.5 to 2% by weight of paraffin;
from 0.4 to 2.3% by weight of triceteareth-4-phosphate; from 1.5 to 4% by weight of propylene glycol; from 1.3 to 4.2% by weight of glycerol; from 1 to 3% by weight of cetyl sarcosinate; from 0.05 to 1% by weight of allantoin; and water as the balance to make 100% by weight.
from 4 to 6% by weight of stearic acid; from 0.5 to 2% by weight of paraffin;
from 0.4 to 2.3% by weight of triceteareth-4-phosphate; from 1.5 to 4% by weight of propylene glycol; from 1.3 to 4.2% by weight of glycerol; from 1 to 3% by weight of cetyl sarcosinate; from 0.05 to 1% by weight of allantoin; and water as the balance to make 100% by weight.
5. The foam skin cream according to any one of claims 1 to 4, additionally containing a silicone-containing compound, in phase I.
6. The foam skin cream according to any one of claims 1 to 5, additionally containing one or more refatting substances in phase I.
7. The foam skin cream according to claim 6, containing at least one of from 0.5 to 2% by weight of decyl oleate; and from 0.5 to 2% by weight of octyldecanol.
8. The foam skin cream according to claim 6, containing at least one of from 3 to 6% by weight of decyl oleate; and from 3 to 6% by weight of octyldecanol.
9. The foam skin cream according to claim 6, containing at least one of:
from 6 to 9% by weight of decyl oleate; and from 6 to 9% by weight of octyldecanol.
from 6 to 9% by weight of decyl oleate; and from 6 to 9% by weight of octyldecanol.
10. The foam skin cream according to any one of claims 1 to 9, additionally containing a hydratizing (moisture-binding) agent in phase II.
11. The foam skin cream according to any one of claims 1 to 10, containing at least one of: polyunsaturated fatty acids, soothing substances, and skin-active vitamins.
12. The foam skin cream according to any one of claims 6 to 10, containing from 3 to 7% by weight of Calendula extract; from 3 to 7% by weight of Hamamelis extract; from 3 to 7% by weight of chamomile extract; from 3 to 7%
by weight of tea tree oil extract; from 1 to 5% by weight of decyl oleate; and from 1 to 5% by weight of octyldodecanol.
by weight of tea tree oil extract; from 1 to 5% by weight of decyl oleate; and from 1 to 5% by weight of octyldodecanol.
13. The foam skin cream according to claim 1, 2 or 3 wherein said phase I
mixture additionally contains at least one of unsaturated and polyunsaturated fatty acids.
mixture additionally contains at least one of unsaturated and polyunsaturated fatty acids.
14. The foam skin cream according to claim 1, 2 or 3 wherein said fatty acid is a C10-C22 fatty acid.
15. The foam skin cream according to claim 1, 2 or 3 wherein said coemulsifier is triceteareth-4-phosphate.
16. The foam skin cream according to claim 1, 2 or 3 wherein said moisturizers are selected from the group consisting of propylene glycol and polyhydric alcohols.
17. The foam skin cream according to claim 16 wherein the moisturizer is glycerol.
18. The foam skin cream according to claim 1, 2 or 3 wherein the pH value is adjusted to from 7.6 to 8.2 with a skin-compatible basic organic compound.
19. The foam skin cream according to claim 1, 2 or 3 wherein said skin care additive is allantoin.
20. The foam skin cream according to claim 5 wherein said silicone-containing compound is dimethicone.
21. The foam skin cream according to claim 5 or 20 wherein said silicone-containing compound is in an amount of from 0.05 to 1% by weight.
22. The foam skin cream according to claim 1, 2 or 3 wherein said emulsifier is an alkyl sarcosinate.
23. The foam skin cream according to claim 6 wherein said one or more refatting substances are selected from the group consisting of decyl oleate, isohexadecane, stearic acid glycol ester, coconut fatty acid ethanolamide, corn oil, peanut oil, almond oil, sesame oil, olive oil, jojoba oil, soybean oil, wool wax alcohols, paraffin, medium-chain triglycerides, oleic acid oleyl esters, white petrolatum, macrogol-glycerol hydroxystearate, hydrogenated castor oil, castor oil from Ricinus communis, avocado oil, wheat germ oil, palmitic acid isopropyl ester, cetyl palmitate, myristic acid myristyl ester and octyldo-decanol.
24. The foam skin cream according to claim 10 wherein said hydratizing (moisture-binding) agent in phase II is selected from the group consisting of urea, ethoxydiglycol, sodium chloride, magnesium chloride, sorbitol, dexpanthenol and sodium lactate.
25. The foam skin cream according to claim24 wherein said said hydratizing (moisture-binding) agent is from 1 to 20% by weight of urea.
26. The foam skin cream according to claim 11 wherein said polyunsaturated fatty acids, are w-6 fatty acids.
27. The foam skin cream according to claim 11 wherein said soothing substance is chamomile extract.
28. Use of the foam skin cream according to any one of claims 1 to 27 for the protection from or reduction of the absorption of cancerogenic substances, polycyclic aromatic hydrocarbons, for persons exposed to such substances, acids, lyes (not above pH 11), scouring agents and detergents, sweat, urine, stool, rubber gloves, dusts, house dust, machine, drilling and cooling oils, greases, paints, varnishes, gypsum, aggressive substances and chemicals and other substances and chemicals.
29. Use of the foam skin cream according to any of claims 6 to 12 for the alleviation of dermatological diseases.
30. Use according to claim 29 wherein said diseases are selected from allergic contact dermatitis type I and IV, cumulative-subtoxic eczema, toxic-irritative eczema, microbial-dysregulative eczema, atopic dermatitis, atopic palmoplantar eczema, dyshidrosis, hyperhidrosis, contact urticaria, intertriginous eczema in connection with hemorrhoids, various weeping fungal infections, interdigital mycosis, perlèches, psoriasis vulgaris, ulcus cruris, cholinergic urticaria and diaper dermatitis.
31. Use of the foam skin cream according to claim 10 for the prophylaxis and therapy of diabetic foot.
32. Use of the foam skin cream according to claim 12 for the treatment and prevention of diaper dermatitis.
33. A process for the preparation of a foam skin cream according to any one of claims 1 to 27, comprising:
- preparing a phase I by melting at 75 °C a mixture containing a fatty acid , an emulsifier and a coemulsifier, followed by metering this phase with stirring to - a phase II molten at 75 °C obtained from an aqueous mixture containing at least one of moisturizers, emulsifiers and skin care additives;
- wherein homogeneous mixing of phases I and II is provided and said metering is performed at a temperature of 75 °C;
- after the addition of phase I to phase II, the temperature is maintained at 75 °C
for a period of between 5 and 20 minutes; whereupon - the temperature of the thus obtained mixture is lowered to a temperature of between 30 and 40 °C with constant stirring;
- adjusting the pH value to from 7.6 to 8.2, and -filling into containers with the addition of a propellant.
- preparing a phase I by melting at 75 °C a mixture containing a fatty acid , an emulsifier and a coemulsifier, followed by metering this phase with stirring to - a phase II molten at 75 °C obtained from an aqueous mixture containing at least one of moisturizers, emulsifiers and skin care additives;
- wherein homogeneous mixing of phases I and II is provided and said metering is performed at a temperature of 75 °C;
- after the addition of phase I to phase II, the temperature is maintained at 75 °C
for a period of between 5 and 20 minutes; whereupon - the temperature of the thus obtained mixture is lowered to a temperature of between 30 and 40 °C with constant stirring;
- adjusting the pH value to from 7.6 to 8.2, and -filling into containers with the addition of a propellant.
34. A process according to claim 33 wherein said fatty acid is a C10-C22 fatty acid.
35. A process according to claim 33 or 34 wherein said phase I mixture additionally contains at least one of unsaturated and polyunsaturated fatty acids.
36. A process according to claim 33, 34 or 35 wherein said emulsifier is an alkyl sarcosinate.
37. A process according to claim 33, 34, 35 or 36 wherein said skin care additive is allantoin.
38. A process according to claim 33, 34, 35, 36 or 37 3 wherein said coemulsifier is triceteareth-4-phosphate.
39. A process according to claim 33, 34,35, 36, 37 or 38 wherein the pH
value is adjusted to from 7.6 to 8.2 with a skin-compatible basic organic compound.
value is adjusted to from 7.6 to 8.2 with a skin-compatible basic organic compound.
40. A process according to claim any one of claims 33 to 39 wherein said moisturizers are selected from the group consisting of propylene glycol and polyhydric alcohols.
41. A process according to claim 40 wherein the moisturizer is glycerol.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE19735591 | 1997-08-18 | ||
| DE19735591.9 | 1997-08-18 | ||
| PCT/EP1998/005232 WO1999008649A2 (en) | 1997-08-18 | 1998-08-18 | Foaming skin cream |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CA2300054A1 CA2300054A1 (en) | 1999-02-25 |
| CA2300054C true CA2300054C (en) | 2003-09-30 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CA002300054A Expired - Lifetime CA2300054C (en) | 1997-08-18 | 1998-08-18 | Foam skin cream, uses of the foam skin protection cream and a process for its preparation |
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| Country | Link |
|---|---|
| US (4) | US6423323B2 (en) |
| EP (1) | EP1014916B2 (en) |
| JP (1) | JP4057234B2 (en) |
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| DE (1) | DE59802564D1 (en) |
| DK (1) | DK1014916T4 (en) |
| ES (1) | ES2170522T5 (en) |
| PT (1) | PT1014916E (en) |
| WO (1) | WO1999008649A2 (en) |
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| JP4057234B2 (en) * | 1997-08-18 | 2008-03-05 | ノイブルグ スキン ケア ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | Foam skin cream, use of foam skin protection cream and method for producing the same |
| US8263580B2 (en) * | 1998-09-11 | 2012-09-11 | Stiefel Research Australia Pty Ltd | Vitamin formulation |
| AUPP583198A0 (en) * | 1998-09-11 | 1998-10-01 | Soltec Research Pty Ltd | Mousse composition |
| US6627178B1 (en) * | 1999-07-30 | 2003-09-30 | Garret D. Cawthon | Methods, compositions and systems for the prevention and treatment of diaper rash |
| FR2807321B1 (en) * | 2000-04-06 | 2002-08-30 | Seppic Sa | NEW ACTIVE INGREDIENT, COMPOSITION CONTAINING THE SAME, AND USE IN COSMETICS, DERMOCOSMETICS, DERMOPHARMACY OR PHARMACY OR ON WOVEN OR NONWOVEN MEDIA |
| US8512718B2 (en) | 2000-07-03 | 2013-08-20 | Foamix Ltd. | Pharmaceutical composition for topical application |
| FR2817769B1 (en) * | 2000-12-08 | 2003-09-12 | Hospal Ind | APPARATUS FOR THE EXTRACORPOREAL TREATMENT OF BLOOD OR PLASMA COMPRISING A WET SEMI-PERMEABLE MEMBRANE AND METHODS OF MANUFACTURE |
| DE10063341A1 (en) * | 2000-12-19 | 2002-06-20 | Beiersdorf Ag | Cosmetic or dermatological composition contains three-part emulsifier system, lipid phase and gas |
| DE10063342A1 (en) * | 2000-12-19 | 2002-06-20 | Beiersdorf Ag | Cosmetic or dermatological composition contains three-part emulsifier system and gas |
| DE10063340A1 (en) * | 2000-12-19 | 2002-08-29 | Beiersdorf Ag | Self-foaming or foam-like preparations |
| JP2002265347A (en) * | 2001-03-13 | 2002-09-18 | Shiseido Co Ltd | Cosmetic promoting maturation of cornified envelope |
| DE10113050A1 (en) * | 2001-03-15 | 2002-09-19 | Beiersdorf Ag | Self-foaming or foamed cosmetic or dermatological composition comprises a specified emulsifier system, a lipid phase, a gas and an organic hydrocolloid |
| DE10113046A1 (en) * | 2001-03-15 | 2002-09-26 | Beiersdorf Ag | Self-foaming product for dermatological and cosmetic products comprises an emulsifier system, a lipid phase, gas, organic hydrocolloid and a solid body |
| DE10134786A1 (en) * | 2001-07-17 | 2003-02-06 | Beiersdorf Ag | Foamable preparations |
| DE10144061A1 (en) * | 2001-09-07 | 2003-04-17 | Beiersdorf Ag | Self-foaming or foam-like preparations with inorganic gel formers, organic hydrocolloids and particulate hydrophobic and / or hydrophobized and / or oil-absorbing solid substances |
| DE10147820A1 (en) * | 2001-09-27 | 2003-04-10 | Beiersdorf Ag | Self-foaming, foam-like, post-foaming or foamable cosmetic or dermatological preparations containing waxes or lipids which are solid and / or semi-solid at room temperature |
| DE10155956A1 (en) * | 2001-11-09 | 2003-05-22 | Beiersdorf Ag | Self-foaming, foam-like, post-foaming or foamable cosmetic or dermatological preparations |
| DE10155792A1 (en) * | 2001-11-14 | 2003-05-22 | Beiersdorf Ag | Self-foaming, foam-like, post-foaming or foamable cosmetic or dermatological preparations containing siloxane elastomers |
| US20030170282A1 (en) * | 2002-03-05 | 2003-09-11 | Walz David K. | Method of skin protection during hair treatment |
| US8053626B2 (en) | 2002-06-12 | 2011-11-08 | Sca Hygiene Products Ab | Absorbent article containing a skincare composition and method of making and using same |
| DE60231704D1 (en) * | 2002-06-12 | 2009-05-07 | Sca Hygiene Prod Ab | Absorbent article with a skin care composition |
| DE10228229A1 (en) * | 2002-06-25 | 2004-03-18 | Beiersdorf Ag | Foamable preparations |
| IL152486A0 (en) * | 2002-10-25 | 2003-05-29 | Meir Eini | Alcohol-free cosmetic and pharmaceutical foam carrier |
| WO2004037225A2 (en) * | 2002-10-25 | 2004-05-06 | Foamix Ltd. | Cosmetic and pharmaceutical foam |
| US20050069566A1 (en) * | 2003-08-04 | 2005-03-31 | Foamix Ltd. | Foam carrier containing amphiphilic copolymeric gelling agent |
| US20070292359A1 (en) * | 2002-10-25 | 2007-12-20 | Foamix Ltd. | Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof |
| US10117812B2 (en) | 2002-10-25 | 2018-11-06 | Foamix Pharmaceuticals Ltd. | Foamable composition combining a polar solvent and a hydrophobic carrier |
| US20080206161A1 (en) * | 2002-10-25 | 2008-08-28 | Dov Tamarkin | Quiescent foamable compositions, steroids, kits and uses thereof |
| US20060018937A1 (en) * | 2002-10-25 | 2006-01-26 | Foamix Ltd. | Steroid kit and foamable composition and uses thereof |
| US20070292461A1 (en) * | 2003-08-04 | 2007-12-20 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US9265725B2 (en) | 2002-10-25 | 2016-02-23 | Foamix Pharmaceuticals Ltd. | Dicarboxylic acid foamable vehicle and pharmaceutical compositions thereof |
| US8119109B2 (en) | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Foamable compositions, kits and methods for hyperhidrosis |
| US7704518B2 (en) | 2003-08-04 | 2010-04-27 | Foamix, Ltd. | Foamable vehicle and pharmaceutical compositions thereof |
| US9211259B2 (en) | 2002-11-29 | 2015-12-15 | Foamix Pharmaceuticals Ltd. | Antibiotic kit and composition and uses thereof |
| US20050205086A1 (en) * | 2002-10-25 | 2005-09-22 | Foamix Ltd. | Retinoid immunomodulating kit and composition and uses thereof |
| US7544674B2 (en) * | 2002-10-25 | 2009-06-09 | Galderma S.A. | Topical skin care composition |
| US8486376B2 (en) | 2002-10-25 | 2013-07-16 | Foamix Ltd. | Moisturizing foam containing lanolin |
| US8119150B2 (en) * | 2002-10-25 | 2012-02-21 | Foamix Ltd. | Non-flammable insecticide composition and uses thereof |
| US20060193789A1 (en) * | 2002-10-25 | 2006-08-31 | Foamix Ltd. | Film forming foamable composition |
| US20060233721A1 (en) * | 2002-10-25 | 2006-10-19 | Foamix Ltd. | Foam containing unique oil globules |
| US8900554B2 (en) | 2002-10-25 | 2014-12-02 | Foamix Pharmaceuticals Ltd. | Foamable composition and uses thereof |
| US9668972B2 (en) | 2002-10-25 | 2017-06-06 | Foamix Pharmaceuticals Ltd. | Nonsteroidal immunomodulating kit and composition and uses thereof |
| US20080317679A1 (en) * | 2002-10-25 | 2008-12-25 | Foamix Ltd. | Foamable compositions and kits comprising one or more of a channel agent, a cholinergic agent, a nitric oxide donor, and related agents and their uses |
| US7700076B2 (en) | 2002-10-25 | 2010-04-20 | Foamix, Ltd. | Penetrating pharmaceutical foam |
| US20080138296A1 (en) | 2002-10-25 | 2008-06-12 | Foamix Ltd. | Foam prepared from nanoemulsions and uses |
| US7820145B2 (en) | 2003-08-04 | 2010-10-26 | Foamix Ltd. | Oleaginous pharmaceutical and cosmetic foam |
| US20050271596A1 (en) * | 2002-10-25 | 2005-12-08 | Foamix Ltd. | Vasoactive kit and composition and uses thereof |
| US20070292355A1 (en) * | 2002-10-25 | 2007-12-20 | Foamix Ltd. | Anti-infection augmentation foamable compositions and kit and uses thereof |
| DE10250755B4 (en) * | 2002-10-31 | 2007-02-08 | Merz Pharma Gmbh & Co. Kgaa | A foamable composition based on an O / W emulsion comprising a combination of a silicone-based emulsifier and an anionic surfactant having improved skin action, their preparation and their use |
| EA009660B1 (en) * | 2002-12-12 | 2008-02-28 | Нойбург Скин Кэа Гмбх & Ко. Кг | Stable foam cream |
| GB0307866D0 (en) * | 2003-04-04 | 2003-05-14 | Novartis Ag | Pharmaceutical composition |
| US7575739B2 (en) | 2003-04-28 | 2009-08-18 | Foamix Ltd. | Foamable iodine composition |
| US7169401B2 (en) * | 2003-07-18 | 2007-01-30 | Hill Dermaceuticals, Inc. | Topical skin care composition containing refined peanut oil |
| US20070140999A1 (en) * | 2003-07-18 | 2007-06-21 | Hill Dermaceuticals, Inc. | Topical skin care composition containing refined peanut oil |
| US8795693B2 (en) | 2003-08-04 | 2014-08-05 | Foamix Ltd. | Compositions with modulating agents |
| US8486374B2 (en) | 2003-08-04 | 2013-07-16 | Foamix Ltd. | Hydrophilic, non-aqueous pharmaceutical carriers and compositions and uses |
| CN1856294A (en) | 2003-08-25 | 2006-11-01 | 弗米克斯有限公司 | Penetrating pharmaceutical foam |
| DE10347824B4 (en) * | 2003-10-10 | 2011-08-11 | Lach, Hans-Joachim, Dr., 79331 | Pharmaceutical or cosmetic composition for the treatment of the skin |
| US20060099173A1 (en) * | 2003-10-24 | 2006-05-11 | Nancy Puglia | Topical skin care composition |
| AU2003274610A1 (en) * | 2003-11-05 | 2005-05-26 | Medena Ag | Foamed skin cream |
| DE10356164A1 (en) | 2003-12-02 | 2005-08-04 | Beiersdorf Ag | Active ingredient combinations of licochalcone A or an extract of Radix Clycyrrhizae inflatae, containing licochalcone A, phenoxyethanol and, if desired, glycerol |
| ZA200507017B (en) * | 2004-02-04 | 2007-03-28 | Foamix Ltd | Cosmetic and pharmaceutical foam with solid matter |
| DE202004021449U1 (en) * | 2004-10-21 | 2008-02-28 | Neubourg Skin Care Gmbh & Co. Kg | Use of urea for the treatment of age spots |
| US8431165B2 (en) * | 2004-12-13 | 2013-04-30 | Swing Aerobics Licensing, Inc. | Medicament for treatment of cancer and other diseases |
| ZA200706401B (en) * | 2005-01-20 | 2008-11-26 | Kayban Pty Ltd | Anti-Microbial Agent |
| JP2008540511A (en) | 2005-05-09 | 2008-11-20 | フォーミックス エルティーディー． | Sugar foaming composition |
| PL2526930T3 (en) * | 2005-06-01 | 2014-05-30 | Glaxosmithkline Ip Dev Ltd | Vitamin formulation |
| US20080152596A1 (en) * | 2005-07-19 | 2008-06-26 | Foamix Ltd. | Polypropylene glycol foamable vehicle and pharmaceutical compositions thereof |
| DE202006004676U1 (en) * | 2005-09-28 | 2007-02-08 | Neubourg Skin Care Gmbh & Co. Kg | Formulation, useful as foam skin cream and to treat e.g. dermatitis and psoriasis, comprises an aqueous emulsion, propellant gas, urea emulsion, hyaluronic acid, free fatty acid and at least two emulsions |
| ES2393761T3 (en) * | 2006-07-14 | 2012-12-27 | Stiefel Research Australia Pty Ltd | Pharmaceutical fatty acid foam |
| EP2061467A4 (en) * | 2006-09-08 | 2013-08-21 | Foamix Ltd | Colored or colorable foamable composition and foam |
| US20080260655A1 (en) | 2006-11-14 | 2008-10-23 | Dov Tamarkin | Substantially non-aqueous foamable petrolatum based pharmaceutical and cosmetic compositions and their uses |
| EP2073794A2 (en) * | 2006-11-14 | 2009-07-01 | Foamix Ltd. | Stable non-alcoholic foamable pharmaceutical emulsion compositions with an unctuous emollient and their uses |
| US7801502B2 (en) * | 2006-12-18 | 2010-09-21 | Aai Corporation | Method for implementing continuous radio frequency (RF) alignment in advanced electronic warfare (EW) signal stimulation systems |
| US20080292560A1 (en) * | 2007-01-12 | 2008-11-27 | Dov Tamarkin | Silicone in glycol pharmaceutical and cosmetic compositions with accommodating agent |
| US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
| US20090130029A1 (en) * | 2007-11-21 | 2009-05-21 | Foamix Ltd. | Glycerol ethers vehicle and pharmaceutical compositions thereof |
| US9439857B2 (en) | 2007-11-30 | 2016-09-13 | Foamix Pharmaceuticals Ltd. | Foam containing benzoyl peroxide |
| WO2010041141A2 (en) | 2008-10-07 | 2010-04-15 | Foamix Ltd. | Oil-based foamable carriers and formulations |
| WO2009072007A2 (en) | 2007-12-07 | 2009-06-11 | Foamix Ltd. | Carriers, formulations, methods for formulating unstable active agents for external application and uses thereof |
| EP2242476A2 (en) | 2008-01-14 | 2010-10-27 | Foamix Ltd. | Poloxamer foamable pharmaceutical compositions with active agents and/or therapeutic cells and uses |
| DE102008020797A1 (en) | 2008-04-22 | 2009-10-29 | Aquyo Cosmetics Gmbh | Skin cream useful for e.g. treatment and/or prophylaxis of dry skin and/or skin damage in diabetic foot, comprises saccharide e.g. mannobiose, polysaccharide e.g. dextran, multivalent alcohol e.g. glycerol, urea, polycation and carrier |
| US8895080B2 (en) | 2008-06-20 | 2014-11-25 | Ocusoft, Inc. | Compositions and kits for ocular treatment |
| US20090317503A1 (en) * | 2008-06-20 | 2009-12-24 | Ocusoft, Inc. | Eyelid Preparation and Method of Use |
| CA2646932A1 (en) * | 2008-12-10 | 2010-06-10 | Lancelot Biotech Inc. | Method for the topical application of a medicinal preparation |
| ES2364692T3 (en) * | 2008-12-23 | 2011-09-12 | Intendis Gmbh | ESSENTIALLY FREE FOAM COMPOSITION OF PHARMACEUTICALLY ACTIVE INGREDIENTS FOR HUMAN SKIN TREATMENT. |
| CA2760186C (en) | 2009-04-28 | 2019-10-29 | Foamix Ltd. | Foamable vehicle and pharmaceutical compositions comprising aprotic polar solvents and uses thereof |
| CA2769677A1 (en) | 2009-07-29 | 2011-02-03 | Foamix Ltd. | Non surface active agent non polymeric agent hydro-alcoholic foamable compositions, breakable foams and their uses |
| CA2769625C (en) | 2009-07-29 | 2017-04-11 | Foamix Ltd. | Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses |
| US8945516B2 (en) | 2009-10-02 | 2015-02-03 | Foamix Pharmaceuticals Ltd. | Surfactant-free water-free foamable compositions, breakable foams and gels and their uses |
| US9849142B2 (en) | 2009-10-02 | 2017-12-26 | Foamix Pharmaceuticals Ltd. | Methods for accelerated return of skin integrity and for the treatment of impetigo |
| PL2335675T3 (en) | 2009-12-10 | 2015-08-31 | Neubourg Skin Care Gmbh & Co Kg | Emulsifier-free, polymer stabilised foam formulas |
| US8409628B2 (en) * | 2010-02-04 | 2013-04-02 | Penguin IP Holdings, Inc. | Methods and compositions for oxygenation of skin to treat skin disorders |
| PL2371350T3 (en) | 2010-03-04 | 2013-09-30 | Neubourg Skin Care Gmbh & Co Kg | Foam formulas for treating animal skin illnesses |
| WO2011123619A2 (en) | 2010-03-31 | 2011-10-06 | Penguin Ip Holdings Inc. | Permeable mixtures, methods and compositions for the skin |
| DE102011018924A1 (en) * | 2011-04-28 | 2012-10-31 | Tunap Industrie Chemie Gmbh & Co. Produktions Kg | OW emulsion concentrate, process for its preparation and skin cosmetic containing it |
| WO2013106647A1 (en) * | 2012-01-13 | 2013-07-18 | Dharma Biomedical, Llc | Supercritical guggul extracts and uses thereof |
| US20140073398A1 (en) * | 2012-09-10 | 2014-03-13 | Gaming Arts LLC | Systems and methods for playing a game of chance with a plurality of processors |
| US9717679B1 (en) | 2012-12-17 | 2017-08-01 | Touchless Designs LLC | Methods for the prevention and treatment of animal skin conditions |
| US9539275B2 (en) * | 2014-01-27 | 2017-01-10 | Hong Kong Baptist University | Melanogenesis effect of saponins of gynostemma pentaphyllum |
| US10258646B2 (en) * | 2014-10-28 | 2019-04-16 | Andrea Rosanoff | Cream transdermal magnesium supplement |
| DE102015221565A1 (en) | 2015-11-04 | 2017-05-04 | Beiersdorf Ag | Cosmetic foam of an emulsion containing glyceryl stearate citrate |
| DE102015221566A1 (en) | 2015-11-04 | 2017-05-04 | Beiersdorf Ag | Cosmetic foam of an emulsion containing sodium cetearyl sulfate and glyceryl monostearate |
| DE102015221568A1 (en) | 2015-11-04 | 2017-05-04 | Beiersdorf Ag | Cosmetic foam of an emulsion containing glycerol and alcohol |
| DE102015221567A1 (en) | 2015-11-04 | 2017-05-04 | Beiersdorf Ag | Cosmetic foam from an emulsion containing betaine |
| EP3468530A4 (en) | 2016-06-10 | 2020-03-11 | Clarity Cosmetics Inc. | Non-comedogenic hair and scalp care formulations and method for use |
| CA2978573A1 (en) | 2016-09-08 | 2018-03-08 | Foamix Pharmaceuticals Ltd. | Compositions and methods for treating rosacea and acne |
| DE102016223502A1 (en) | 2016-11-28 | 2018-05-30 | Beiersdorf Ag | UV-filter-containing, cosmetic foam comprising an emulsion containing sodium cetearyl sulfate and glyceryl monostearate |
| DE102016224029A1 (en) | 2016-12-02 | 2018-06-07 | Beiersdorf Ag | Foaming emulsion-based cleaning preparation-1 |
| CN113069942A (en) * | 2021-04-07 | 2021-07-06 | 杨梦玲 | Mild amino acid soap-based facial cleanser and preparation method thereof |
Family Cites Families (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2968628A (en) * | 1958-10-17 | 1961-01-17 | Shulton Inc | Propellant composition |
| SE325667B (en) * | 1968-03-06 | 1970-07-06 | Medisan Ab | |
| US3970584A (en) * | 1973-02-14 | 1976-07-20 | S. C. Johnson & Son, Inc. | Aerosol package containing a foam-forming emulsion and propellent system |
| US4145411A (en) * | 1974-09-05 | 1979-03-20 | Colgate-Palmolive Company | Pressurized foaming shaving composition |
| US4137302A (en) * | 1976-04-02 | 1979-01-30 | Lever Brothers Company | Cosmetic composition |
| LU83173A1 (en) * | 1981-02-27 | 1981-06-05 | Oreal | NOVEL COSMETIC COMPOSITIONS FOR THE TREATMENT OF HAIR AND SKIN CONTAINING POWDER RESULTING FROM THE SPRAYING OF AT LEAST ONE PLANT AND A COHESION AGENT |
| US4661340A (en) * | 1983-06-06 | 1987-04-28 | Interkemia Vegyipari Gazdasagi Tarsasag | Quail egg based stabilized foam compositions for cosmetic purposes |
| US4551480A (en) * | 1983-06-21 | 1985-11-05 | Stiefel Laboratories, Inc. | Compositions for the treatment of psoriasis |
| DE3330628C2 (en) * | 1983-08-25 | 1985-11-07 | Schülke & Mayr GmbH, 2000 Norderstedt | Skin protection and care lotion |
| US5002680A (en) * | 1985-03-01 | 1991-03-26 | The Procter & Gamble Company | Mild skin cleansing aerosol mousse with skin feel and moisturization benefits |
| GB2172298B (en) * | 1985-03-01 | 1988-11-23 | Procter & Gamble | Mild detergent mousse |
| DE3628531A1 (en) * | 1986-08-22 | 1988-02-25 | Merz & Co Gmbh & Co | FOAMABLE CREAMS |
| US5000938A (en) * | 1988-08-12 | 1991-03-19 | Innovatec S.A. | Protective aerated foam hand lotion and process for preparing the same |
| GB9003199D0 (en) * | 1990-02-13 | 1990-04-11 | Unilever Plc | Topical composition |
| US5472686A (en) * | 1990-12-28 | 1995-12-05 | Nippon Unicar Company Limited | Cosmetic formulations |
| US5277336A (en) * | 1990-12-31 | 1994-01-11 | L'oreal | Device for the pressurized dispensing of a product, especially a foaming product, and processes for filling a container for a device of this kind |
| US5086903A (en) * | 1991-04-08 | 1992-02-11 | Interrolll Holding Ag | Tandem brake roller system |
| EP0613369A1 (en) * | 1991-11-22 | 1994-09-07 | Richardson-Vicks, Inc. | Combined personal cleansing and moisturizing compositions |
| US5278263A (en) * | 1992-10-05 | 1994-01-11 | The Goodyear Tire & Rubber Company | Syndiotactic 1,2-polybutadiene synthesis in an aqueous medium utilizing N,N-dibutylformamide as a modifier |
| DE4238860A1 (en) | 1992-11-19 | 1994-05-26 | Medicon Gmbh | Skin protection products for the protection of human skin |
| US5334387A (en) * | 1993-02-23 | 1994-08-02 | Colgate-Palmolive Company | Topical composition comprising mono and dialkyl phosphates with a cosurfactant |
| US5616746A (en) * | 1993-04-15 | 1997-04-01 | L'oreal | Use in cosmetics of lipophilic derivatives of amino deoxyalditols, cosmetic compositions containing them, and novel alkyl carbamates |
| ZA946016B (en) * | 1993-08-30 | 1996-02-12 | Colgate Palmolice Company | An aerosol shaving cream formulation |
| DE4407015C2 (en) * | 1994-03-03 | 1996-01-25 | Henkel Kgaa | Cosmetic and / or pharmaceutical preparations |
| DE4420625C1 (en) * | 1994-06-14 | 1995-11-02 | Beiersdorf Ag | Active substance combination with a content of glycerylalkyl ethers and cosmetic and dermatological preparations containing such active substance combinations |
| US5525588A (en) * | 1994-09-14 | 1996-06-11 | Elzabeth Arden Co. | Cosmetic composition |
| US5534265A (en) * | 1994-08-26 | 1996-07-09 | The Procter & Gamble Company | Thickened nonabrasive personal cleansing compositions |
| US5500211A (en) * | 1994-09-22 | 1996-03-19 | The Gillette Company | Soap-free self-foaming shave gel composition |
| US5540853A (en) * | 1994-10-20 | 1996-07-30 | The Procter & Gamble Company | Personal treatment compositions and/or cosmetic compositions containing enduring perfume |
| FR2725897B1 (en) * | 1994-10-24 | 1996-12-06 | Oreal | PRODUCT FOR TOPICAL APPLICATION CONTAINING A LIPASE AND AN ACTIVE PRECURSOR |
| DE69509554T2 (en) * | 1994-12-06 | 1999-12-23 | Procter & Gamble | STORAGE LIQUID SKIN CLEANING COMPOSITION WITH YELLOWING POLYMERS, LIPIDS AND ATHYLENE GLYCOLETIC ACID ESTERS |
| US5653970A (en) * | 1994-12-08 | 1997-08-05 | Lever Brothers Company, Division Of Conopco, Inc. | Personal product compositions comprising heteroatom containing alkyl aldonamide compounds |
| FR2741801B1 (en) * | 1995-12-01 | 1998-01-02 | Oreal | USE OF A POLYHOLOSIDE IN A CLEANSING OR MAKE-UP REMOVER COMPOSITION, AND COMPOSITION COMPRISING SAME |
| US6086903A (en) * | 1996-02-26 | 2000-07-11 | The Proctor & Gamble Company | Personal treatment compositions and/or cosmetic compositions containing enduring perfume |
| USH2013H1 (en) * | 1997-05-23 | 2002-02-05 | The Procter & Gamble Company | Skin care compositions |
| JP4057234B2 (en) * | 1997-08-18 | 2008-03-05 | ノイブルグ スキン ケア ゲゼルシャフト ミット ベシュレンクテル ハフツング ウント コンパニー コマンディトゲゼルシャフト | Foam skin cream, use of foam skin protection cream and method for producing the same |
-
1998
- 1998-08-18 JP JP2000509390A patent/JP4057234B2/en not_active Expired - Fee Related
- 1998-08-18 AT AT98943893T patent/ATE210954T1/en active
- 1998-08-18 DE DE59802564T patent/DE59802564D1/en not_active Expired - Lifetime
- 1998-08-18 EP EP98943893A patent/EP1014916B2/en not_active Expired - Lifetime
- 1998-08-18 PT PT98943893T patent/PT1014916E/en unknown
- 1998-08-18 WO PCT/EP1998/005232 patent/WO1999008649A2/en active IP Right Grant
- 1998-08-18 CA CA002300054A patent/CA2300054C/en not_active Expired - Lifetime
- 1998-08-18 ES ES98943893T patent/ES2170522T5/en not_active Expired - Lifetime
- 1998-08-18 DK DK98943893.2T patent/DK1014916T4/en active
- 1998-08-18 AU AU91624/98A patent/AU9162498A/en not_active Abandoned
- 1998-08-18 US US09/485,930 patent/US6423323B2/en not_active Expired - Lifetime
-
2002
- 2002-07-17 US US10/196,726 patent/US20030059394A1/en not_active Abandoned
-
2005
- 2005-07-14 US US11/180,913 patent/US20060018938A1/en not_active Abandoned
-
2007
- 2007-12-11 US US12/000,314 patent/US20080213193A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU9162498A (en) | 1999-03-08 |
| DK1014916T3 (en) | 2002-04-15 |
| PT1014916E (en) | 2002-06-28 |
| EP1014916B2 (en) | 2011-06-15 |
| CA2300054A1 (en) | 1999-02-25 |
| EP1014916B1 (en) | 2001-12-19 |
| ES2170522T3 (en) | 2002-08-01 |
| JP2001515022A (en) | 2001-09-18 |
| DK1014916T4 (en) | 2011-09-26 |
| ES2170522T5 (en) | 2011-11-14 |
| US20060018938A1 (en) | 2006-01-26 |
| ATE210954T1 (en) | 2002-01-15 |
| US6423323B2 (en) | 2002-07-23 |
| WO1999008649A3 (en) | 1999-05-14 |
| JP4057234B2 (en) | 2008-03-05 |
| US20020001599A1 (en) | 2002-01-03 |
| US20080213193A1 (en) | 2008-09-04 |
| EP1014916A2 (en) | 2000-07-05 |
| US20030059394A1 (en) | 2003-03-27 |
| DE59802564D1 (en) | 2002-01-31 |
| WO1999008649A2 (en) | 1999-02-25 |
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