CA2552242A1 - Cosmetic composition containing a protein and an enzyme inhibitor - Google Patents

Cosmetic composition containing a protein and an enzyme inhibitor Download PDF

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Publication number
CA2552242A1
CA2552242A1 CA002552242A CA2552242A CA2552242A1 CA 2552242 A1 CA2552242 A1 CA 2552242A1 CA 002552242 A CA002552242 A CA 002552242A CA 2552242 A CA2552242 A CA 2552242A CA 2552242 A1 CA2552242 A1 CA 2552242A1
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CA
Canada
Prior art keywords
protein
extract
forming agent
group
film
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
CA002552242A
Other languages
French (fr)
Other versions
CA2552242C (en
Inventor
Paolo U. Giacomoni
Abul M. Manirazman
Peter J. Lentini
Harvey Gedeon
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
EL Management LLC
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Individual
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Filing date
Publication date
Application filed by Individual filed Critical Individual
Publication of CA2552242A1 publication Critical patent/CA2552242A1/en
Application granted granted Critical
Publication of CA2552242C publication Critical patent/CA2552242C/en
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/645Proteins of vegetable origin; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9711Phaeophycota or Phaeophyta [brown algae], e.g. Fucus
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9717Rhodophycota or Rhodophyta [red algae], e.g. Porphyra
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9706Algae
    • A61K8/9722Chlorophycota or Chlorophyta [green algae], e.g. Chlorella
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q17/00Barrier preparations; Preparations brought into direct contact with the skin for affording protection against external influences, e.g. sunlight, X-rays or other harmful rays, corrosive materials, bacteria or insect stings
    • A61Q17/04Topical preparations for affording protection against sunlight or other radiation; Topical sun tanning preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/78Enzyme modulators, e.g. Enzyme agonists
    • A61K2800/782Enzyme inhibitors; Enzyme antagonists

Abstract

The present invention is a cosmetic composition comprising a water-soluble protein-based film-forming agent, the film-forming agent having a tertiary structure capable of undergoing a helix-coil transformation, a protease inhibitor in an amount sufficient to protect the protein on the stratum corneum and a cosmetically acceptable vehicle so that the protease inhibitor prolongs the pulling effect of the film-forming agent.

Claims (42)

1. A cosmetic composition comprising:
a water-soluble protein-based film-forming agent, the film-forming agent having a tertiary structure capable of spontaneously undergoing a helix-coil transformation;
a protease inhibitor in an amount sufficient to protect the protein on the stratum corneum;
an anti-penetrant in an amount sufficient to keep the film-forming agent on the stratum corneum; and a cosmetically acceptable vehicle.
2. The cosmetic composition of claim 1 wherein the film-forming agent is selected from the group consisting of plant, vegetable, algae, bacterial, animal-derived or biotechnologically synthesized proteins.
3. The cosmetic composition of claim 1 wherein the water-soluble protein-based film-forming agent is selected from the group consisting of silk protein, almond protein, milk protein, whey protein, soy protein, tobacco leaf protein, bacterial protein, egg white protein and fibrous protein from beans.
4. The cosmetic composition of claim 1 wherein the protease inhibitor is selected from the group consisting of hops extract, passion flower, black current and grape leaf extract, hydrolized ulva lactuca extract, betel nut extract, blue algae extract, egg extract, white birch extract, allicin, aprotinin, leupeptin, bestatin, pepstatin A, N-alpha-p-tosyl-L-lysyl-chloromethyl-ketone and trypsin-chimotrypsin inhibitors.
5. The cosmetic composition of claim 1 further comprising a skin care active.
6. The cosmetic composition of claim 5 wherein the skin care active is selected from the list consisting of anti-aging, anti-acne and sunscreen agents.
7. The cosmetic composition of claim 1 further comprising an anti-exfoliant.
8. A cosmetic composition comprising:

a water-soluble protein-based film-forming agent, the film-forming agent having a tertiary structure and being capable of spontaneously undergoing a helix-coil transformation;
a protease inhibitor in an amount sufficient to protect the protein on the stratum corneum; and a cosmetically acceptable vehicle.
9. The cosmetic composition of claim 8 wherein the film-forming agent is selected from the group consisting of plant, vegetable, algae, bacterial, animal-derived or biotechnologically synthesized proteins.
10. The cosmetic composition of claim 9 wherein the film-forming agent is selected from the group consisting of silk protein, almond protein, milk protein, whey protein, soy protein, tobacco leaf protein, bacterial protein, egg white protein and fibrous protein from beans.
11. The cosmetic composition of claim 8 wherein the protease inhibitor is selected from the group consisting of hops extract, passion flower, black current and grape leaf extract, hydrolized ulva lactuca extract, betel nut extract, blue algae extract, egg extract, white birch extract, allicin, aprotinin, leupeptin, bestatin, pepstatin A, N-alpha-p-tosyl-L-lysyl-chloromethyl-ketone and trypsin-chimotrypsin inhibitors.
12. The cosmetic composition of claim 8 further comprising a skin care active.
13. The cosmetic composition of claim 8 wherein the skin care active is selected from the group consisting of anti-aging, anti-acne and sunscreen agents.
14. The cosmetic composition of claim 8 further comprising an anti-penetrant.
15. The cosmetic composition of claim 8 further comprising an anti-exfoliant.
16. A method of enhancing the appearance of skin comprising applying a cosmetic or pharmaceutical composition comprising a water-soluble protein-based film-forming agent, the film-forming agent having a tertiary structure and being capable of spontaneously undergoing a helix-coil transformation to cause a pulling effect; a protease inhibitor in an amount sufficient to protect the protein on the stratum corneum, and a cosmetically acceptable vehicle.
17. The method of claim 16 wherein the film-forming agent is selected from the group consisting of plant, vegetable, algae, bacterial, animal-derived or biotechnologically synthesized proteins.
18. The method of claim 16 wherein the film-forming agent is selected from the group consisting of silk protein, almond protein, milk protein, whey protein, soy protein, tobacco leaf protein, bacterial protein, egg white protein and fibrous protein from beans.
19. The method of claim 16 wherein the protease inhibitor is selected from the group consisting of hops extract, passion flower, black current and grape leaf extract, hydrolized ulva lactuca extract, betel nut extract, blue algae extract, egg extract, white birch extract, allicin, aprotinin, leupeptin, bestatin, pepstatin A, N-alpha-p-tosyl-L-lysyl-chloromethyl-ketone and trypsin-chimotrypsin inhibitors.
20. The method of claim 16 wherein the composition further comprises a skin care active.
21. The method of claim 20 wherein the skin care active is selected from the group consisting of anti-aging, anti-acne and sunscreen agents.
22. The method of claim 16 wherein the composition further comprises an anti-exfoliant.
23. A method of improving the condition of skin comprising applying a cosmetic or pharmaceutical composition comprising a water-soluble protein-based film-forming agent, the film-forming agent having a tertiary structure capable of spontaneously undergoing a helix-coil transformation to cause a pulling effect, a protease inhibitor in an amount sufficient to protect the protein on the stratum corneum, a skin care active, and a cosmetically acceptable vehicle.
24. The method of claim 23 wherein the film-forming agent is selected from the group consisting of plant, vegetable, algae, bacterial, animal-derived, or biotechnologically synthesized proteins.
25. The method of claim 23 wherein the film-forming agent is selected from the group consisting of silk protein, almond protein, milk protein, whey protein, soy protein, tobacco leaf protein, bacterial protein, egg white protein and fibrous protein from beans.
26. The method of claim 23 wherein the protease inhibitor is selected from the group consisting of hops extract, passion flower, black current and grape leaf extract, hydrolized ulva lactuca extract, betel nut extract, blue algae extract, egg extract, white birch extract, allicin, aprotinin, leupeptin, bestatin, pepstatin A, N-alpha-p-tosyl-L-lysyl-chloromethyl-ketone and trypsin-chimotrypsin inhibitors.
27. The method of claim 23 wherein the skin care active is selected from the group consisting of anti-aging, anti-acne and sunscreen agents.
28. The method of claim 23 wherein the composition further comprises an anti-exfoliant.
29. A method of prolonging a pulling effect on the surface of the skin due to the water-soluble protein-based film-forming agent in order to minimize the appearance of wrinkles, comprising applying a cosmetic or pharmaceutical composition comprising the film-forming agent in combination with a protease inhibitor in an amount sufficient to protect the protein on the stratum corneum, and a cosmetically acceptable vehicle.
30. The method of claim 29 wherein the film-forming agent is selected from the group consisting of plant, vegetable, algae, bacterial, animal-derived, or biotechnologically synthesized proteins.
31. The method of claim 29 wherein the film-forming agent is selected from the group consisting of silk protein, almond protein, milk protein, whey protein, soy protein, tobacco leaf protein, bacterial protein, egg white protein and fibrous protein from beans.
32. The method of claim 29 wherein the protease inhibitor is selected from the group consisting of hops extract, passion flower, black current and grape leaf extract, hydrolized ulva lactuca extract, betel nut extract, blue algae extract, egg extract, white birch extract, allicin, aprotinin, leupeptin, bestatin, pepstatin A, N-alpha-p-tosyl-L-lysyl-chloromethyl-ketone and trypsin-chimotrypsin inhibitors.
33. The method of claim 29 wherein the composition further comprises a skin care active.
34. The method of claim 33 wherein the skin care active is selected from the group consisting of anti-aging, anti-acne and sunscreen agents.
35. The method of claim 29 wherein the composition further comprises an anti-exfoliant.
36. A method of reducing the symptoms of skin aging comprising applying to skin in need of such reduction, a cosmetic or pharmaceutical composition comprising a water-soluble protein-based film-forming agent, the film-forming agent having a tertiary structure and being capable of spontaneously undergoing a helix-coil transformation to cause a pulling effect, a protease inhibitor in an amount sufficient to protect the protein on the stratum corneum and a cosmetically acceptable vehicle.
37. The method of claim 36 wherein the film-forming agent is selected from the group consisting of plant, vegetable, algae, bacterial, animal-derived, or biotechnologically synthesized proteins.
38. The method of claim 36 wherein the film-forming agent is selected from the group consisting of silk protein, almond protein, milk protein, whey protein, soy protein, tobacco leaf protein, bacterial protein, egg white protein and fibrous protein from beans.
39. The method of claim 36 wherein the protease inhibitor is selected from the group consisting of hops extract, passion flower, black current and grape leaf extract, hydrolized ulva lactuca extract, betel nut extract, blue algae extract, egg extract, white birch extract, allicin, aprotinin, leupeptin, bestatin, pepstatin A, N-alpha-p-tosyl-L-lysyl-chloromethyl-ketone and trypsin-chimotrypsin inhibitors.
40. The method of claim 36 further comprising a skin care active wherein the skin care active is selected from the group consisting of anti-aging and sunscreen agents.
41. The method of claim 36 wherein the composition further comprises an anti-exfoliant.
42. The method of claim 36 in which the symptom of skin aging is selected from the group consisting of lines, wrinkles, skin atrophy, skin thinning and combinations thereof.
CA2552242A 2004-01-07 2005-01-04 Cosmetic composition containing a protein and an enzyme inhibitor Expired - Fee Related CA2552242C (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US53519804P 2004-01-07 2004-01-07
US60/535,198 2004-01-07
PCT/US2005/000090 WO2005067691A2 (en) 2004-01-07 2005-01-04 Cosmetic composition containing a protein and an enzyme inhibitor

Publications (2)

Publication Number Publication Date
CA2552242A1 true CA2552242A1 (en) 2005-07-28
CA2552242C CA2552242C (en) 2010-03-30

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Family Applications (1)

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CA2552242A Expired - Fee Related CA2552242C (en) 2004-01-07 2005-01-04 Cosmetic composition containing a protein and an enzyme inhibitor

Country Status (7)

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US (2) US20050147572A1 (en)
EP (1) EP1708677A4 (en)
JP (1) JP2007517883A (en)
KR (1) KR100798607B1 (en)
AU (1) AU2005204621B2 (en)
CA (1) CA2552242C (en)
WO (1) WO2005067691A2 (en)

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Also Published As

Publication number Publication date
KR100798607B1 (en) 2008-01-28
KR20060115758A (en) 2006-11-09
WO2005067691A3 (en) 2006-06-22
CA2552242C (en) 2010-03-30
JP2007517883A (en) 2007-07-05
WO2005067691A2 (en) 2005-07-28
EP1708677A4 (en) 2010-12-22
US20050147572A1 (en) 2005-07-07
AU2005204621B2 (en) 2007-03-08
US20100003206A1 (en) 2010-01-07
AU2005204621A1 (en) 2005-07-28
EP1708677A2 (en) 2006-10-11

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