CN101953779A - Medical disinfection gel - Google Patents

Medical disinfection gel Download PDF

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Publication number
CN101953779A
CN101953779A CN 201010502347 CN201010502347A CN101953779A CN 101953779 A CN101953779 A CN 101953779A CN 201010502347 CN201010502347 CN 201010502347 CN 201010502347 A CN201010502347 A CN 201010502347A CN 101953779 A CN101953779 A CN 101953779A
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Prior art keywords
agent
ethanol
medical
regulator
thickening agent
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CN 201010502347
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Chinese (zh)
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CN101953779B (en
Inventor
杨泽秀
林栋青
邹佳辰
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Shandong Weigao Hongrui Medical Technology Co Ltd
Shandong Weigao Pharmaceutical Co Ltd
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Shandong Weigao Pharmaceutical Co Ltd
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Abstract

The invention relates to a medical disinfection gel, which consists of o-phenylphenol, ethanol, a thickening agent, a humectant, a pH regulator and deionized water, wherein the mass percentage of each component is as follows: 1.0-5.0% of o-phenylphenol, 55-65% of ethanol, 1.0-5.0% of thickening agent, 3.0-8.0% of humectant, 1.0-3.0% of pH regulator and the balance of deionized water. The invention takes o-phenylphenol as a main effective active ingredient, selects ethanol as a synergistic effect agent, and has good gelling performance by adding a thickening agent, a humectant and a pH regulator. The invention has the advantages of reasonable formula, stable performance, convenient use, cleanness, rapidness, good sterilization effect, reliable effect, no harm to skin and no potential health risk. Is especially suitable for medical hand washing and hand wiping disinfection.

Description

A kind of medical disinfecting gel
Technical field
The present invention relates to a kind of medical disinfecting articles for use, specifically a kind of medical disinfecting gel.Be mainly used in medical hands sterilization.
Background technology
We know that the hospital infection problem becomes increasingly conspicuous, and have become the public health problem that solution is badly in need of in hospital.The medical worker is in numerous and complicated medical treatment, nursery work, and many work are all finished by hands, and the various on hand number of bacteria of medical personnel are often many than other crowds, and the microbial contamination of hands is quite serious.Cross infection due to medical personnel's hand contamination is to cause one of main risk factors of nosocomial infection.This process though hospital's operations routine is all washed one's hands, but medical personnel's the present situation of washing one's hands allows of no optimist, there are the medical personnel about 50% under the situation of not washing one's hands, to be engaged in curative activity, main cause is that medical personnel's inconvenience in various operating process is washed one's hands or washed one's hands and do as a mere formality, worrying in addition frequently washes one's hands and sterilize produces stimulation and xerosis cutis to skin, and therefore most handwashing disinfections are in unconscious state.
The massive epidemiology investigation confirms that hands is the arch-criminal who propagates hospital infection, and washing one's hands with aseptic technique is to block medical personnel to cause propagating the key link of infection through hand operated, and it also is basic, the most cheap, the most simple and easy to do means.The medical disinfecting gel has the washing of exempting from, rapid-drying properties, quick-acting, Disinfection Effect is held characteristics such as effect, has been widely used in hand hygiene sterilization and the sterilization of surgical operation remote holder.At present the medical disinfecting gel sold of market mainly is serve as mainly effective disinfection composition with trichloro hydroxyl diphenyl ether (triclosan) and ethanol, but on April 15th, 2004, the report first of London The EveningStandard caused that people can cause the extensive concern of potential health risk to the use of triclosan.The EveningStandard reports according to the research of the Dr. Pe2ter Vikesland of Virginia, US Polytechnics, remains in the chlorine reaction in the water in triclosan meeting and the tap water processing procedure, generates chloroform (chloroform).Chloroform is a kind of moderately toxic organic compound that has, and can enter body through digestive tract, respiratory tract, contact skin, mainly acts on the central nervous system, has anesthetic action, and can damage heart, liver, kidney.Zoopery finds that chloroform has high fetal toxicity and slight teratogenecity, can induce white mice that hepatocarcinoma takes place.
The appearance of " superbug " at present allows the people again sight be transferred on the resistance.As far back as on August 6th, 1998, the Dr.Stuart Levy of U.S. Tufts University write articles on Nature Journal (Nature), pointed out excessively to use triclosan class antibacterial may cause the Drug resistance of antibacterial, and generation can be resisted the novel bacterial of triclosan.One piece of paper of authorities,medical magazine " lancet " publication on August 11st, 2010 warns that researcher has been found that a kind of " superbug ", and it can allow malignant bacteria become incomparably powerful, resists nearly all antibiotic.At present, this " superbug " imports Britain into from South Asia, and spreads to the whole world probably.Britain causes the superbug NDM-1 of at least five dead cases, invasion North America, because of most of antibiotic is developed immunity to drugs, probably pasts medical help after the infection.BMH announces that Britain has entered on developing the way of antibiotics, but scientist warns that possibility can not have in 10 years the effectively new antibiotic of NDM-1 is occurred.
Summary of the invention
Technical problem to be solved by this invention is to overcome above-mentioned the deficiencies in the prior art, provide a kind of prescription rationally, stable performance, easy to usely, refreshing clean have good bactericidal effect fast, reliable for effect, do not injure skin, do not have the medical disinfecting gel of potential health risk.
The technical scheme that the present invention solves the problems of the technologies described above employing is: a kind of medical disinfecting gel, it is made up of o-phenyl phenol, ethanol, thickening agent, wetting agent, pH regulator agent, deionized water, the quality percentage composition of various compositions is an o-phenyl phenol 1.0 ~ 5.0%, ethanol 55 ~ 65%, thickening agent 1.0 ~ 5.0%, wetting agent 3.0 ~ 8.0%, pH regulator agent 1.0 ~ 3.0%, surplus is a deionized water.
The present invention preferably forms proportioning (quality): o-phenyl phenol 2.0%, and ethanol 60%, carbomer thickening agent 1.5%, propylene glycol 2.0%, glycerol 3.0%, triethanolamine pH regulator agent 2.0%, surplus is a deionized water.
Thickening agent of the present invention can be selected hydroxypropyl emthylcellulose or materials such as carboxymethyl cellulose or carbomer or sodium alginate for use.Wetting agent of the present invention can select 1 for use, one or both in 2-propylene glycol, the glycerol.PH regulator agent of the present invention can be selected materials such as sodium hydroxide or triethanolamine for use.
The present invention is main effectively active component with the o-phenyl phenol, and as the agent of cleaning corrosion-proof and sterilization, selecting ethanol for use is the cooperative effect agent, because ethanol has good bactericidal property, can work in coordination with the effect that plays quick sterilization with o-phenyl phenol.The present invention has good gelling performance by adding thickening agent, wetting agent, pH regulator agent.Against existing technologies, the present invention fills a prescription rationally, stable performance, easy to use, refreshing clean quick, has good bactericidal effect, and is reliable for effect, do not injure skin, do not have potential health risk.Be specially adapted to the medical hands sterilization of washing one's hands, wipe.
The specific embodiment
The invention will be further described below in conjunction with embodiment.
A kind of medical disinfecting gel of the present invention, it is made up of o-phenyl phenol, ethanol, thickening agent, wetting agent, pH regulator agent, deionized water, the quality percentage composition of various compositions is an o-phenyl phenol 1.0 ~ 5.0%, ethanol 55 ~ 65%, thickening agent 1.0 ~ 5.0%, wetting agent 3.0 ~ 8.0%, pH regulator agent 1.0 ~ 3.0%, surplus is a deionized water.
The present invention is to be main effectively active component with the o-phenyl phenol, and as the agent of cleaning corrosion-proof and sterilization, selecting ethanol for use is the cooperative effect agent, because ethanol has good bactericidal property, can work in coordination with the effect that plays quick sterilization with o-phenyl phenol.Thickening agent of the present invention can be selected hydroxypropyl emthylcellulose or materials such as carboxymethyl cellulose or carbomer or sodium alginate for use, has good gelling performance.Wetting agent of the present invention can select 1 for use, and one or both in 2-propylene glycol, the glycerol make gel have good toughness, and active component has persistent bactericidal effect.PH regulator agent of the present invention can be selected materials such as sodium hydroxide or triethanolamine for use.
The preparation method of medical disinfecting gel of the present invention is: take by weighing corresponding thickening agent by formula proportion, gradation joins it in proper amount of deionized water, in the process that adds, stir while adding, leave standstill 24h and make its abundant swelling, o-phenyl phenol is dissolved to corresponding ethanol, the wetting agent that adds formula proportion, stir, it is joined in the thickening agent swelling solution then, stir, in the solution that mixes, add corresponding pH regulator agent, regulate pH and make it be the clear gel state, stir.
The present invention is main effectively active component with the o-phenyl phenol, and selecting ethanol for use is the cooperative effect agent, by adding thickening agent, wetting agent, pH regulator agent, has good gelling performance.The present invention fills a prescription rationally, stable performance, easy to use, refreshing clean quick, has good bactericidal effect, and is reliable for effect, do not injure skin, do not have potential health risk.Be specially adapted to the medical hands sterilization of washing one's hands, wipe.
Embodiment 1: a kind of medical disinfecting gel, it is made up of o-phenyl phenol, ethanol, thickening agent, wetting agent, pH regulator agent, deionized water, the quality percentage composition of various compositions is an o-phenyl phenol 5.0%, ethanol 55%, carbomer thickening agent 1.0%, propylene glycol 3.0%, glycerol 3.0%, triethanolamine pH regulator agent 1.0%, surplus are deionized water.Take by weighing carbomer by formula proportion, gradation joins it in proper amount of deionized water, in the process that adds, just add just and stir, leave standstill 24h and make its abundant swelling, take by weighing required o-phenyl phenol it is dissolved in the corresponding ethanol, add the wetting agent of formula proportion, stir, it is joined in the thickening agent swelling solution then, stir, in the solution that mixes, add corresponding pH regulator agent, regulate pH and make it be the clear gel state, stir, obtain the medical disinfecting gel, its prescription rationally, stable performance, easy to use, refreshing clean quick, have good bactericidal effect, do not injure skin, do not have potential health risk.Be specially adapted to the medical hands sterilization of washing one's hands, wipe.
Embodiment 2: a kind of medical disinfecting gel, it is made up of o-phenyl phenol, ethanol, thickening agent, wetting agent, pH regulator agent, deionized water, the quality percentage composition of various compositions is an o-phenyl phenol 2.0%, ethanol 60%, carbomer thickening agent 1.5%, propylene glycol 2.0%, glycerol 3.0%, triethanolamine pH regulator agent 2.0%, surplus are deionized water.Take by weighing carbomer by formula proportion, gradation joins it in proper amount of deionized water, in the process that adds, just add just and stir, leave standstill 24h and make its abundant swelling, take by weighing required o-phenyl phenol it is dissolved in the corresponding ethanol, add the wetting agent of formula proportion, stir, it is joined in the thickening agent swelling solution then, stir, in the solution that mixes, add corresponding pH regulator agent, regulate pH and make it be the clear gel state, stir, obtain the medical disinfecting gel, its prescription rationally, stable performance, easy to use, refreshing clean quick, have good bactericidal effect, do not injure skin, do not have potential health risk.Be specially adapted to the medical hands sterilization of washing one's hands, wipe.
Embodiment 3: a kind of medical disinfecting gel, it is made up of o-phenyl phenol, ethanol, thickening agent, wetting agent, pH regulator agent, deionized water, the quality percentage composition of various compositions is an o-phenyl phenol 1.0%, ethanol 65%, carbomer thickening agent 5.0%, propylene glycol 3.0%, triethanolamine pH regulator agent 3.0%, surplus is a deionized water.Take by weighing carbomer by formula proportion, gradation joins it in proper amount of deionized water, in the process that adds, just add just and stir, leave standstill 24h and make its abundant swelling, take by weighing required o-phenyl phenol it is dissolved in the corresponding ethanol, add the wetting agent of formula proportion, stir, it is joined in the thickening agent swelling solution then, stir, in the solution that mixes, add corresponding pH regulator agent, regulate pH and make it be the clear gel state, stir, obtain the medical disinfecting gel, its prescription rationally, stable performance, easy to use, refreshing clean quick, have good bactericidal effect, do not injure skin, do not have potential health risk.Be specially adapted to the medical hands sterilization of washing one's hands, wipe.

Claims (5)

1. medical disinfecting gel, it is characterized in that it is made up of o-phenyl phenol, ethanol, thickening agent, wetting agent, pH regulator agent, deionized water, the quality percentage composition of various compositions is: o-phenyl phenol 1.0 ~ 5.0%, ethanol 55 ~ 65%, thickening agent 1.0 ~ 5.0%, wetting agent 3.0 ~ 8.0%, pH regulator agent 1.0 ~ 3.0%, surplus is a deionized water.
2. medical hands disinfecting gel according to claim 1 is characterized in that the quality percentage composition of said each constituent is: o-phenyl phenol 2.0%, ethanol 60%, carbomer thickening agent 1.5%, propylene glycol 2.0%, glycerol 3.0%, triethanolamine pH regulator agent 2.0%, surplus are deionized water.
3. medical hands disinfecting gel according to claim 1 is characterized in that said thickening agent is hydroxypropyl emthylcellulose or carboxymethyl cellulose or carbomer or sodium alginate.
4. medical hands disinfecting gel according to claim 1 is characterized in that said wetting agent is 1, one or both in 2-propylene glycol, the glycerol.
5. medical hands disinfecting gel according to claim 1 is characterized in that said pH regulator agent is a triethanolamine.
CN2010105023478A 2010-10-11 2010-10-11 Medical disinfection gel Active CN101953779B (en)

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CN101953779B CN101953779B (en) 2012-05-23

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Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103768007A (en) * 2012-10-26 2014-05-07 杭州元祺生物科技有限公司 Medical disinfecting gel
CN105030661A (en) * 2015-08-14 2015-11-11 稳健医疗用品股份有限公司 Disinfection gel and preparing method of disinfection gel
CN107158273A (en) * 2017-06-08 2017-09-15 苏州凌科特新材料有限公司 Medical disinfection gel and preparation method thereof
CN107412081A (en) * 2017-09-15 2017-12-01 南通荣成医药化工有限公司 A kind of medical disinfecting water
CN111567518A (en) * 2020-05-27 2020-08-25 山东省科学院能源研究所 Gel-like sodium hypochlorite disinfectant and preparation method and application thereof
CN113491788A (en) * 2020-03-20 2021-10-12 山东威高药业股份有限公司 Composition for digestive tract wound and digestive tract wound gel

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136771A (en) * 1999-06-23 2000-10-24 The Dial Corporation Compositions containing a high percent saturation concentration of antibacterial agent
US20040247685A1 (en) * 2001-10-23 2004-12-09 Shanta Modak Gentle-acting skin-disinfectants and hydroalcoholic gel formulations
CN101194877A (en) * 2006-12-09 2008-06-11 边平达 Water washing avoiding disinfection hand cleaning gel rubber and method for producing the same
CN101698107A (en) * 2009-09-03 2010-04-28 顾海 Sterilizing medical ultrasonic coupling agent

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6136771A (en) * 1999-06-23 2000-10-24 The Dial Corporation Compositions containing a high percent saturation concentration of antibacterial agent
US20040247685A1 (en) * 2001-10-23 2004-12-09 Shanta Modak Gentle-acting skin-disinfectants and hydroalcoholic gel formulations
US6846846B2 (en) * 2001-10-23 2005-01-25 The Trustees Of Columbia University In The City Of New York Gentle-acting skin disinfectants
CN101194877A (en) * 2006-12-09 2008-06-11 边平达 Water washing avoiding disinfection hand cleaning gel rubber and method for producing the same
CN101698107A (en) * 2009-09-03 2010-04-28 顾海 Sterilizing medical ultrasonic coupling agent

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103768007A (en) * 2012-10-26 2014-05-07 杭州元祺生物科技有限公司 Medical disinfecting gel
CN105030661A (en) * 2015-08-14 2015-11-11 稳健医疗用品股份有限公司 Disinfection gel and preparing method of disinfection gel
CN107158273A (en) * 2017-06-08 2017-09-15 苏州凌科特新材料有限公司 Medical disinfection gel and preparation method thereof
CN107412081A (en) * 2017-09-15 2017-12-01 南通荣成医药化工有限公司 A kind of medical disinfecting water
CN113491788A (en) * 2020-03-20 2021-10-12 山东威高药业股份有限公司 Composition for digestive tract wound and digestive tract wound gel
CN111567518A (en) * 2020-05-27 2020-08-25 山东省科学院能源研究所 Gel-like sodium hypochlorite disinfectant and preparation method and application thereof

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Address after: No.20, Xingshan Road, torch hi tech Industrial Development Zone, Weihai City, Shandong Province 264200

Patentee after: SHANDONG WEIGAO PHARMACEUTICAL Co.,Ltd.

Address before: 264200 No. 332-9, Shichang Avenue, high tech District, Weihai City, Shandong Province

Patentee before: Shandong Wego Pharmaceutical Co.,Ltd.

TR01 Transfer of patent right
TR01 Transfer of patent right

Effective date of registration: 20220510

Address after: 264200 No. 70, Long'an Road, Gushan Town, economic and Technological Development Zone, Weihai City, Shandong Province (self declaration)

Patentee after: Shandong Weigao Hongrui Medical Technology Co.,Ltd.

Address before: No.20, Xingshan Road, torch hi tech Industrial Development Zone, Weihai City, Shandong Province 264200

Patentee before: SHANDONG WEIGAO PHARMACEUTICAL Co.,Ltd.