CN102988200A - Liposome face-nourishing skin care product - Google Patents
Liposome face-nourishing skin care product Download PDFInfo
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- CN102988200A CN102988200A CN2012105242648A CN201210524264A CN102988200A CN 102988200 A CN102988200 A CN 102988200A CN 2012105242648 A CN2012105242648 A CN 2012105242648A CN 201210524264 A CN201210524264 A CN 201210524264A CN 102988200 A CN102988200 A CN 102988200A
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Abstract
The invention relates to a liposome face-nourishing skin care product, belonging to the technical field of cosmetics. The liposome face-nourishing skin care product comprises the following components in parts by weight: 0.5-8.0 parts of epidermal growth factor (EGF), 0.01-0.1 part of human stem cell growth factor (SCGF), 10.0-10,000.0 parts of hyaluronic acid, 0.003-3000.0 parts of phospholipid, 0.001-10.0 parts of metallothionein, 0.001-10.0 parts of collagen, 0.01-100.0 parts of male larva, and 0.001-200.0 parts of cholesterol. The skin care product provided by the invention has the beneficial effects that the liposome is composed of phospholipid bilayers and contains pure water micro vesicles, and the vesicles can enclose a certain amount of nutrients and essences, are 100 nanometers in mean diameter which is 1/200-1/300 of the human cell diameter, can easily penetrate through the surface layer of human skin and can be fused with cells, thus exerting efficacy. The skin care product can deeply humidify horny cells and enhance hydration to improve the skin softness, and can provide sufficient nutrients to ensure skin health and increase skin resistance.
Description
Technical field
The present invention relates to a kind of liposome face nourishing skin care products, relate in particular to and a kind ofly solve enough that skin is intensely dark, flexibility decrease, aging problem and can the pore convergence, smooth the liposome face nourishing skin care products of wrinkle, belong to the cosmetic product technical field.
Background technology
Skin is comprised of epidermis, corium, subcutaneous fat and appendages.Epidermal area is outermost one deck of skin, is divided into from inside to outside: basal cell layer, prickle cell layer, granular cell layer, clear cell layer and horn cell layer.Skin appendages comprises hair, hair follicle, sebaceous gland and sweat gland.Skin mainly absorbs external substance, i.e. horny layer, pilosebaceous unit and the antiperspirant mouth of pipe by three approach.Its mesocuticle is the most important approach that skin absorbs, skin can only absorb some electrolyte under normal circumstances, small-molecule substance and liposoluble substance, can not directly absorb for some macro-molecular proteins, in the daily life, most skin care milks are aqueous solutions, and the superficial growth factor, human stem cell growth (SCGF), protein, aminoacid, barbaloin, the important life active compound such as vitamin all is water miscible, and the exogenous lipid of horny layer secretion and the endogenous lipid of sebaceous gland Lipid Secretion are oily matter, and water soluble nutrients chance oiliness lipid is insoluble, as shown in Figure 1, therefore cause conventional water solublity skin care item utilization rate very little, for a long time use the water solublity skin care item, cause easily the nutritional labeling waste and stop up easily pore.
Summary of the invention
For overcoming the existing shortcoming of prior art, goal of the invention of the present invention provides a kind of liposome face nourishing skin care products, it is take liposome as carrying China, various nutritional labelings are carried to deep skin, fully absorbed by human body, these skin care item solve enough that skin is intensely dark, flexibility decrease, aging problem and can the pore convergence, smooth wrinkle.
For realizing described goal of the invention, a kind of liposome face nourishing skin care products of the present invention, it comprises the composition of following ratio of weight and number:
Preferably, it also comprises the composition of following ratio of weight and number:
Compared with prior art, liposome face nourishing skin care products provided by the invention, it is take liposome as carrying China, various nutritional labelings are carried to deep skin, can promote propagation and the growth of skin tissue cell, make the cell of newborn youth substitute rapidly old and feeble dead cell, thus the mean age of reducing the cell that consists of skin, with the dim light of solution skin, flexibility decrease and aging problem, and whitening skin, wrinkle are reduced.
Description of drawings
Fig. 1 is the sketch map of the skin absorption process of the skin care item that provide in the prior art;
Fig. 2 is the sketch map of the skin absorption process of liposome face nourishing skin care products provided by the invention.
The specific embodiment
The present invention is further illustrated below in conjunction with specific embodiment.
Embodiment 1
This embodiment provides a kind of can solve the dim light of skin, flexibility decrease and aging, and the liposome face nourishing skin care products that whitening skin, wrinkle are reduced.Described liposome face nourishing skin care products comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Human stem cell growth (SCGF) | 0.01-0.1 |
| Hyaluronic acid | 10.0-10,000.0 |
| Phospholipid | 10-3000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Arbutin | 0.01-100.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome face nourishing skin care products that this embodiment provides is: phosphatidase 11 00mg, cholesterol 25mg are dissolved in the 30ml ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing that 3.0mg epidermal growth factor, 0.05mgSCGF (available from Peprotech company), 2000mg hyaluronic acid, 5mg metallothionein, 5mg collagen protein and 25mg arbutin are dissolved in the 40ml deionized water (perhaps aqueous phosphatic PH=6.8) and constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then above-mentioned aqueous solution II is added in the above-mentioned eggplant-shape bottle, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-120 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying the liposome face nourishing skin care products of an epithelical cell growth factor (EGF), human stem cell growth (SCGF), hyaluronic acid, metallothionein, collagen protein, arbutin and cholesterol.
Fig. 2 is the sketch map of the skin absorption process of liposome face nourishing skin care products provided by the invention.As shown in Figure 2 because to seal the liposome adventitia of nutritional labeling similar to human body cell outer membrane structure and composition, so gap and the direct transdermal of skin subsidiary pipeline opening that complete liposome can pass between horn cell, the horn cell enter site of action.Liposome provides exogenous bilayer lipid membrane, make structural change between horn cell, hydrophobicity afterbody arrangement disorder in the double-layer of lipoid, fat-soluble medicine can enter intercellular substance by diffusion and capillarity, horny layer humidifying and hydration are strengthened, thereby can be penetrated easily the horny layer of epidermis and arrive each position of skin.Liposome provides necessary fatty acid and lipid bilayer, liposome phospholipid and Stratum corneum lipids merge changes the horny layer the Nomenclature Composition and Structure of Complexes, form a kind of flat grain structure of half, by the lipid granule gap, liposomal encapsulated medicine or nutritional labeling are convenient to enter skin, via lipid exchange, fusion, safeguard the physiological function of skin, therefore the liposome of sealing nutritional labeling or medicine has the biomembranous characteristic of human body cell and function, affect the activity of cell, to participate in the human body metabolism, keep one of necessary basic substance of human normal physiological function, have targeting as pharmaceutical carrier, long-lasting, pardon, lipotropy and hydrophilic.Because liposome has avirulence and immunogenicity; be applicable to biological vivo degradation; can protect the entrapped superficial growth factor and metallothionein etc., and can carry the nutritional labelings such as the superficial growth factor and metallothionein and pass horny layer and enter corium and subcutaneous tissue.Alleviation, the controlled release superficial growth factor and metallothionein etc. in corium and subcutaneous tissue.Because liposome has targeting, can improve the superficial growth factor and metallothionein etc. in the bioavailability of skin.
The prepared liposome face nourishing skin care products of this embodiment is on probation through 100 Mies of 30 years old to 45 years old, and after 20 days, 95% people's skin light on the face is gorgeous, pale, and elasticity strengthens, wrinkle reduces.
Embodiment 2
This embodiment provides a kind of dim light of skin, flexibility decrease and aging of enough solving, and whitening skin, wrinkle are reduced, and can make skin keep moistening liposome face nourishing skin care products.Described liposome face nourishing skin care products comprises the composition of the weight part ratio described in the following table:
| Composition | Concrete content mg |
| Epithelical cell growth factor (EGF) | 0.5-8.0 |
| Vascular endothelial cell growth factor (VEGF) | 0.05-8.0 |
| Hyaluronic acid | 10.0-10,000.0 |
| Human stem cell growth | 0.01-0.1 |
| Phospholipid | 10-3000.0 |
| Metallothionein | 0.001-10.0 |
| Collagen protein | 0.001-10.0 |
| Elastin laminin | 0.001-10.0 |
| Fibrous protein | 0.001-10.0 |
| Arbutin | 0.01-100.0 |
| Barbaloin | 0.001-100.0 |
| Aminoacid | 0.001-10.0 |
| Vitamin E | 0.001-1000.0 |
| Vitamin C | 0.001-1000.0 |
| Cholesterol | 0.001-200.0 |
The preparation method of the liposome face nourishing skin care products that this embodiment provides is: phosphatidase 11 00mg, vitamin E2 5mg and cholesterol 25mg are dissolved in the 40ml ethanol (perhaps chloroform, methanol or dichloromethane etc.), even the solution I of vibrating, then put into eggplant-shape bottle, constantly rotating under the jolting on the water-bath Rotary Evaporators, reduction vaporization desolventizes (35 ℃ ± 1 ℃ of bath temperature) to remove, and pass into every now and then nitrogen, until fully volatilization, then at room temperature dry 24 hours; Take by weighing the 3.0mg epidermal growth factor, (0.05mgSCGF available from Peprotech company), 1mg vascular endothelial cell growth factor (VEGF), the 1000mg hyaluronic acid, the 5mg metallothionein, the 5mg collagen protein, the 5mg elastin laminin, the 5mg fibrous protein, the 20mg arbutin, the 20mg barbaloin, 5mg aminoacid and 25mg vitamin C are dissolved in the 50ml deionized water (perhaps aqueous phosphatic PH=6.8) and are constantly shaking up to get aqueous solution II under the rotation jolting on the water-bath Rotary Evaporators; Then above-mentioned aqueous solution II is added in the above-mentioned eggplant-shape bottle, constantly obtaining the liposome emulsion under the rotation jolting on the water-bath Rotary Evaporators, spy formula Ultrasound Instrument makes the abundant aquation 20-120 of lipid membrane minute under the ice-water bath condition, until become transparently to emulsion, obtain carrying an epithelical cell growth factor (EGF), vascular endothelial cell growth factor (VEGF), VEGF, hyaluronic acid, stem cell factor, metallothionein, collagen protein, elastin fiber shape albumen, arbutin, barbaloin, aminoacid, the liposome face nourishing skin care products of vitamin E and vitamin C etc.
Liposome can be protected the nutritional labelings such as entrapped epidermal growth factor, SCGF (available from Peprotech company), hyaluronic acid, metallothionein, collagen protein, elastin laminin, fibrous protein, arbutin, barbaloin, aminoacid, vitamin E and vitamin C to pass horny layer and enter corium and subcutaneous tissue, is fully absorbed and utilizes.
The liposome face nourishing skin care products that present embodiment is produced is on probation through 100 Mies of 35 years old to 45 years old, and after 10 days, 95% people's skin light on the face is gorgeous moist, pale, and elasticity strengthens, wrinkle reduces.After 30 days, 98% people's wrinkle is almost eliminated, skin bright and cleanly moistens, mottle and freckle are obviously eliminated, and skin elasticity strengthens greatly, and will have a competition with the front obvious youth that seems.
In addition, can liposome and solution separating be opened with the SephadexG50 chromatographic column if need.
Liposome face nourishing skin care products provided by the invention is the high-tech carrier for active principle in a kind of tip, consisted of by the phospholipid bimolecular, include the miniature vesicle of water purification, the nutritional labelings such as the quantitative epidermal growth factor of the internal energy encapsulation of vesicle, metallothionein, human stem cell, its average diameter is 100 nanometers, is 1/200～1/300 of human body cell diameter, can penetrate easily the human body skin top layer, with cell fusion, the performance effect.Therefore, liposome face nourishing skin care products provided by the invention, can promote cell regeneration, solve the dim light of skin, flexibility decrease and aging problem and have good skin care effect, can go deep into the humidifying horn cell and strengthen hydration improving the flexibility of skin, thereby can repair the normal physiological function that the cell that damage is arranged is safeguarded skin; Can provide enough nutrient to guarantee the health of skin, strengthen skin resistance; Have superpower moist moisture-keeping function: have efficient moisture-keeping functions, the deep layer moisturizing improves the dry water shortage status of skin.
The effect that below describes in conjunction with the embodiments component of the present invention, preparation method in detail and reach, but embodiment only is for the explanation the present invention of demonstration ground.Description only is for explaining claims.But protection scope of the present invention is not limited to description.Any those skilled in the art of being familiar with are in the technical scope that the present invention discloses, and the variation that can expect easily or replacement all should be encompassed within protection scope of the present invention.Therefore, protection scope of the present invention should be as the criterion with the protection domain of claims.
Claims (2)
1. Liposomes face skin care item of recuperating, it comprises the composition of following ratio of weight and number:
2. liposome face nourishing skin care products according to claim 1, it also comprises the composition of following ratio of weight and number:
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
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| CN201210524264.8A CN102988200B (en) | 2012-12-10 | 2012-12-10 | Liposome face-nourishing skin care product |
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|---|---|---|---|
| CN201210524264.8A CN102988200B (en) | 2012-12-10 | 2012-12-10 | Liposome face-nourishing skin care product |
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| CN102988200A true CN102988200A (en) | 2013-03-27 |
| CN102988200B CN102988200B (en) | 2014-09-17 |
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| CN201210524264.8A Expired - Fee Related CN102988200B (en) | 2012-12-10 | 2012-12-10 | Liposome face-nourishing skin care product |
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Cited By (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103276002A (en) * | 2013-05-31 | 2013-09-04 | 吉林农业大学 | Oil body containing oil body protein and collagen fusion protein |
| CN103505403A (en) * | 2013-09-29 | 2014-01-15 | 广州市娇兰化妆品有限公司 | Epidermal growth factor compound lipidosome as well as preparation method and application thereof |
| CN104606078A (en) * | 2015-02-06 | 2015-05-13 | 深圳唯美度生物科技有限公司 | Whitening cream applied to sensitive skin |
| CN105055187A (en) * | 2015-09-14 | 2015-11-18 | 广州赛莱拉干细胞科技股份有限公司 | Facial rejuvenation cosmetic preparation and preparation method for same |
| CN107510620A (en) * | 2017-09-26 | 2017-12-26 | 广西民族大学 | A kind of moisturizing whitening is dispelled the formula of Essence |
| WO2018144093A3 (en) * | 2016-11-03 | 2019-03-07 | Pinsky Mark A | Formulations for improved skin care |
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Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103276002A (en) * | 2013-05-31 | 2013-09-04 | 吉林农业大学 | Oil body containing oil body protein and collagen fusion protein |
| CN103505403A (en) * | 2013-09-29 | 2014-01-15 | 广州市娇兰化妆品有限公司 | Epidermal growth factor compound lipidosome as well as preparation method and application thereof |
| CN103505403B (en) * | 2013-09-29 | 2015-08-19 | 广州市娇兰化妆品有限公司 | Epidermal growth factor composite liposome body and its preparation method and application |
| CN104606078A (en) * | 2015-02-06 | 2015-05-13 | 深圳唯美度生物科技有限公司 | Whitening cream applied to sensitive skin |
| CN105055187A (en) * | 2015-09-14 | 2015-11-18 | 广州赛莱拉干细胞科技股份有限公司 | Facial rejuvenation cosmetic preparation and preparation method for same |
| CN105055187B (en) * | 2015-09-14 | 2018-02-09 | 广州赛莱拉干细胞科技股份有限公司 | A kind of face rejuvenation cosmetic formulation and preparation method thereof |
| WO2018144093A3 (en) * | 2016-11-03 | 2019-03-07 | Pinsky Mark A | Formulations for improved skin care |
| CN107510620A (en) * | 2017-09-26 | 2017-12-26 | 广西民族大学 | A kind of moisturizing whitening is dispelled the formula of Essence |
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| CN102988200B (en) | 2014-09-17 |
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