CN1033278A - Technology for producing ginsenoside re monomer - Google Patents
Technology for producing ginsenoside re monomer Download PDFInfo
- Publication number
- CN1033278A CN1033278A CN 87108002 CN87108002A CN1033278A CN 1033278 A CN1033278 A CN 1033278A CN 87108002 CN87108002 CN 87108002 CN 87108002 A CN87108002 A CN 87108002A CN 1033278 A CN1033278 A CN 1033278A
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- China
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- monomer
- ginsenoside
- ethanol
- technology
- ginseng juice
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Abstract
Technology for producing ginsenoside Re monomer is to be raw material with ginseng juice, extract the novel method of ginsenoside Re monomer, the ginseng juice is condensed into medicinal extract, with ethanol sedimentation, filtration, reclaim ethanol to doing, add the water extracted with diethyl ether, precipitate the Re crude product, go up the silica gel G post then,, make with ethanol-water recrystallization.
With the ginsenoside Re monomer purity height of this explained hereafter, yield is many, and cost is low.
Description
The invention belongs to the Natural Medicine Chemistry field.
Ginsenoside Re monomer is the reference substance that the saponin content of the quality evalution of genseng and ginseng product is measured, and has certain physiologically active.In production and scientific research, very big purposes is arranged all.The extraction of ginseng monomer saponin at present with separate the part that used raw material is a ginseng, the method for employing is repeatedly a column chromatography repeatedly.Need a large amount of reagent and silica gel ， And and yield very low, the highest must measuring also can only be calculated with milligram, and costs an arm and a leg.Purpose of the present invention is for satisfying the requirement of production and scientific research, reduce cost, improving yield.The method of extracting ginsenoside is studied.Each position of genseng (ginseng, stem, leaf, flower, fruit juice, seed) screened, invented with the ginseng juice and done raw material, extract the novel method of ginsenoside Re monomer.
Technical scheme of the present invention is that the ginseng juice is condensed into medicinal extract, adds 95% ethanol sedimentation, filters, and reclaims ethanol to doing thin up.Use extracted with diethyl ether again, precipitate 24 hours and separate out the ginsenoside Re monomer crude product, go up the silica gel G post then.Gained Re uses methanol-water (1: 1) recrystallization again, gets the pure product of Re.(spectroscopically pure).
Specific embodiment:
Get ginseng juice 3000me, be condensed into the about 160me of medicinal extract, add 95% ethanol 1000me and precipitate, filtration under diminished pressure reclaims ethanol to doing, and adds water to the 60me dilution, and the 40me that adds diethyl ether again places and gets about 4 grams of thick Re after 24 hours.
With silica gel G chromatographic column on this thick Re dry method (with about 180 grams of silica gel) with chloroform: methyl alcohol: water is 65: 35: 10 developping agent wash-outs, checks Re solution purity, evaporate to dryness with thin layer plate, adds the water that doubles behind the dissolve with methanol, places 24 hours.Separate out the pure product crystallization of Re, get ginsenoside Re monomer after the drying.
Claims (2)
1, a kind of ginseng juice is the production technique of raw material production ginsenoside Re monomer, it is characterized in that the ginseng juice is concentrated, and adds ethanol sedimentation, reclaims ethanol to doing, and adds water, with extracted with diethyl ether, makes the ginsenoside Re monomer crude product.
2, production technique as claimed in claim 1 is characterized in that the ginsenoside Re monomer crude product that will make.With silica gel G post on the dry method, make with the methanol-water recrystallization.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87108002 CN1033278A (en) | 1987-11-24 | 1987-11-24 | Technology for producing ginsenoside re monomer |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN 87108002 CN1033278A (en) | 1987-11-24 | 1987-11-24 | Technology for producing ginsenoside re monomer |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN1033278A true CN1033278A (en) | 1989-06-07 |
Family
ID=4816319
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN 87108002 Pending CN1033278A (en) | 1987-11-24 | 1987-11-24 | Technology for producing ginsenoside re monomer |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN1033278A (en) |
Cited By (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1048283C (en) * | 1996-03-12 | 2000-01-12 | 金凤燮 | Method for extracting asponin composition from traditional Chinese medicinal material with enzymic processing |
| CN1061988C (en) * | 1994-05-03 | 2001-02-14 | 厦门同安皂素厂 | Method of extracting dioscorea saponin from dioscorea plant |
| CN1081922C (en) * | 1998-08-28 | 2002-04-03 | 吉林省集安制药有限公司 | Medicinal composition containing ginsenoside Re, preparation and usage thereof |
| CN1092204C (en) * | 1998-07-28 | 2002-10-09 | 吉林大学基础医学院科技开发中心 | Semisynthesizing method for 20(S)-ginsenoside Rg3, and use in medicine |
| CN1092203C (en) * | 1998-07-22 | 2002-10-09 | 北京鑫利恒医药科技发展有限公司 | Process for extracting ginsenoside Re, and use of medicine thereof |
| US6576286B1 (en) | 1999-04-23 | 2003-06-10 | E Excel International | Cactus fruit drinks and food products |
| CN1303095C (en) * | 2004-09-03 | 2007-03-07 | 吉林大学 | Ginseng saponin superhigh pressure extraction process |
| CN100443497C (en) * | 2004-04-27 | 2008-12-17 | 吉林省宏久生物科技股份有限公司 | Method for extraction of ginseng fruit glucoside |
| CN102464693A (en) * | 2010-11-05 | 2012-05-23 | 李慧 | Ginsenoside Re extraction and separation method |
| CN106188208A (en) * | 2016-07-25 | 2016-12-07 | 西安岳达生物科技股份有限公司 | A kind of method prepared by ginsenoside's RE high-purity technical |
-
1987
- 1987-11-24 CN CN 87108002 patent/CN1033278A/en active Pending
Cited By (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1061988C (en) * | 1994-05-03 | 2001-02-14 | 厦门同安皂素厂 | Method of extracting dioscorea saponin from dioscorea plant |
| CN1048283C (en) * | 1996-03-12 | 2000-01-12 | 金凤燮 | Method for extracting asponin composition from traditional Chinese medicinal material with enzymic processing |
| CN1092203C (en) * | 1998-07-22 | 2002-10-09 | 北京鑫利恒医药科技发展有限公司 | Process for extracting ginsenoside Re, and use of medicine thereof |
| CN1092204C (en) * | 1998-07-28 | 2002-10-09 | 吉林大学基础医学院科技开发中心 | Semisynthesizing method for 20(S)-ginsenoside Rg3, and use in medicine |
| CN1081922C (en) * | 1998-08-28 | 2002-04-03 | 吉林省集安制药有限公司 | Medicinal composition containing ginsenoside Re, preparation and usage thereof |
| US6576286B1 (en) | 1999-04-23 | 2003-06-10 | E Excel International | Cactus fruit drinks and food products |
| CN100443497C (en) * | 2004-04-27 | 2008-12-17 | 吉林省宏久生物科技股份有限公司 | Method for extraction of ginseng fruit glucoside |
| CN1303095C (en) * | 2004-09-03 | 2007-03-07 | 吉林大学 | Ginseng saponin superhigh pressure extraction process |
| CN102464693A (en) * | 2010-11-05 | 2012-05-23 | 李慧 | Ginsenoside Re extraction and separation method |
| CN102464693B (en) * | 2010-11-05 | 2015-05-13 | 李慧 | Ginsenoside Re extraction and separation method |
| CN106188208A (en) * | 2016-07-25 | 2016-12-07 | 西安岳达生物科技股份有限公司 | A kind of method prepared by ginsenoside's RE high-purity technical |
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| C01 | Deemed withdrawal of patent application (patent law 1993) | ||
| WD01 | Invention patent application deemed withdrawn after publication |