CN103922879A - Device for removing residual solvents out of thermo-sensitive solid chemicals - Google Patents
Device for removing residual solvents out of thermo-sensitive solid chemicals Download PDFInfo
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- CN103922879A CN103922879A CN201410158688.6A CN201410158688A CN103922879A CN 103922879 A CN103922879 A CN 103922879A CN 201410158688 A CN201410158688 A CN 201410158688A CN 103922879 A CN103922879 A CN 103922879A
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- still
- thermo
- desolventizing
- residual solvent
- residual
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- 239000013557 residual solvent Substances 0.000 title claims abstract description 25
- 239000007787 solid Substances 0.000 title claims abstract description 13
- 239000000126 substance Substances 0.000 title abstract description 3
- 238000005057 refrigeration Methods 0.000 claims description 18
- 238000001179 sorption measurement Methods 0.000 claims description 6
- 238000005194 fractionation Methods 0.000 claims description 5
- 239000004593 Epoxy Substances 0.000 claims description 2
- 238000007789 sealing Methods 0.000 claims description 2
- 238000000926 separation method Methods 0.000 abstract description 7
- 238000000605 extraction Methods 0.000 abstract description 3
- 230000000274 adsorptive effect Effects 0.000 abstract 2
- 238000004807 desolvation Methods 0.000 abstract 2
- 238000004904 shortening Methods 0.000 abstract 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 27
- 239000002904 solvent Substances 0.000 description 19
- 239000000843 powder Substances 0.000 description 14
- 239000003814 drug Substances 0.000 description 13
- CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 10
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 10
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 6
- 229940079593 drug Drugs 0.000 description 6
- 239000000741 silica gel Substances 0.000 description 6
- 229910002027 silica gel Inorganic materials 0.000 description 6
- 238000001816 cooling Methods 0.000 description 5
- 238000012545 processing Methods 0.000 description 5
- 230000006837 decompression Effects 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 description 4
- 229960002930 sirolimus Drugs 0.000 description 4
- QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- XAUDJQYHKZQPEU-KVQBGUIXSA-N 5-aza-2'-deoxycytidine Chemical compound O=C1N=C(N)N=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 XAUDJQYHKZQPEU-KVQBGUIXSA-N 0.000 description 3
- HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 description 3
- CBPNZQVSJQDFBE-FUXHJELOSA-N Temsirolimus Chemical compound C1C[C@@H](OC(=O)C(C)(CO)CO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 CBPNZQVSJQDFBE-FUXHJELOSA-N 0.000 description 3
- 229960003603 decitabine Drugs 0.000 description 3
- 230000000694 effects Effects 0.000 description 3
- 229960005167 everolimus Drugs 0.000 description 3
- 239000004744 fabric Substances 0.000 description 3
- 239000002594 sorbent Substances 0.000 description 3
- 229960000235 temsirolimus Drugs 0.000 description 3
- QFJCIRLUMZQUOT-UHFFFAOYSA-N temsirolimus Natural products C1CC(O)C(OC)CC1CC(C)C1OC(=O)C2CCCCN2C(=O)C(=O)C(O)(O2)C(C)CCC2CC(OC)C(C)=CC=CC=CC(C)CC(C)C(=O)C(OC)C(O)C(C)=CC(C)C(=O)C1 QFJCIRLUMZQUOT-UHFFFAOYSA-N 0.000 description 3
- 230000007812 deficiency Effects 0.000 description 2
- CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 1
- 230000009286 beneficial effect Effects 0.000 description 1
- 235000011089 carbon dioxide Nutrition 0.000 description 1
- 239000012809 cooling fluid Substances 0.000 description 1
- 238000013461 design Methods 0.000 description 1
- 230000001627 detrimental effect Effects 0.000 description 1
- 238000010586 diagram Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 239000012530 fluid Substances 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 238000000859 sublimation Methods 0.000 description 1
- 230000008022 sublimation Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
Abstract
The invention provides a device for removing residual solvents out of thermo-sensitive solid chemicals. The device comprises a CO2 cylinder, a purifier, a refrigerating device I, a refrigerating device II, a CO2 high-pressure pump, a desolvation kettle, a adsorptive separation kettle, a flowmeter and multiple valves, wherein the CO2 cylinder, the purifier, the refrigerating device I, the CO2 high-pressure pump, the refrigerating device II, the desolvation kettle, the adsorptive separation kettle and the flowmeter are sequentially connected. The device is capable of shortening the extraction time and furthermore improving the extraction efficiency and is an efficient environment-friendly device.
Description
Technical field
The present invention relates to remove the device of residual solvent in solid pharmaceutical, particularly, relate to one and remove equilibrium temperature below 0 DEG C and be insoluble in high pressure CO
2thermo-sensitivity solid pharmaceutical in the device of residual solvent.
Background technology
Residual solvent in medicine refers to the organic substance residues in medicine production process.Residual solvent can be detrimental to health, and national Bureau of Drugs Supervision has formulated strict standard to the content of residual solvent, so it is very necessary that residual solvent in medicine is removed.
Utilize supercritical CO
2the residual solvent that fluid device removes in some drugs has been obtained good effect, but this device is not suitable for the thermo-sensitivity medicine of equilibrium temperature below 0 DEG C.The applicant finds through research, adopts high pressure CO
2also can obtain better effects at 0 DEG C of residual solvent removing below in thermo-sensitivity solid pharmaceutical.The inventor has proposed a kind of employing high pressure CO in patent (application number is 201410103811.4)
2in 0 DEG C removes thermo-sensitivity solid pharmaceutical below, the device of residual solvent, can obtain good effect, removes long deficiency of residual solvent time but exist.
Summary of the invention
In order to improve above-mentioned deficiency, the present invention proposes a kind of ultrasonic wave assisted cryogenic high pressure CO
2remove the device of residual solvent, can low temperature remove plurality of stable temperature below 0 DEG C and be insoluble in high pressure CO
2thermo-sensitivity medicine in residual solvent, remove that the residual solvent time is short, efficiency is high, effective.
In order to achieve the above object, technical scheme of the present invention is: comprise CO
2gas cylinder 1, cleaner 3, refrigeration plant I 4, II 9, CO
2high-pressure pump 6, desolventizing still 13, fractionation by adsorption still 21, under meter 24 and multiple valve 2,5,7,8,10,11,12,16,17,19,20,22,23, described CO
2gas cylinder 1, cleaner 3, refrigeration plant I 4, CO
2high-pressure pump 6, refrigeration plant II 9, desolventizing still 13, fractionation by adsorption still 21, under meter 24 connect successively.
Described desolventizing still 13 internal pressures are that 10～40MPa, temperature are-20～0 DEG C.
In described desolventizing still 13, install ultrasonic transducer 14 additional, each ultrasonic transducer 14 power are 30-800W, and preferably power is 100W; Resonant frequency is 20-100KHz, and preferably resonant frequency is 28 ± 2KHz.
Described on desolventizing still 13 perforate be convenient to line between ultrasonic transducer 14 and ultrasonic generator 15, this hole epoxy sealing.
The beneficial effect of apparatus of the present invention: the present invention proposes one efficiently fast eliminating equilibrium temperature below 0 DEG C and be insoluble in high pressure CO
2thermo-sensitivity solid pharmaceutical in the device of residual solvent; This device adopts ultrasonic wave assisted cryogenic high pressure CO
2extraction residual solvent, mass-transfer efficiency is higher, removes the residual solvent time short, has improved removal efficiency; CO
2recycle, environmental protection, is easy to promote the use of.
Brief description of the drawings
Fig. 1 is the device schematic diagram that removes residual solvent in thermo-sensitivity solid pharmaceutical; (1-CO
2gas cylinder, 2-valve, 3-cleaner, 4-refrigeration plant I, 5-valve, 6-CO
2high-pressure pump, 7-check valve, 8-valve, 9-refrigeration plant II, 10-check valve, 11-valve, 12-blow-off valve, 13-desolventizing still, 14-ultrasonic transducer, 15-ultrasonic generator, 16-safety valve, 17-valve, 18-vacuum pump, 19-back pressure valve, 20-blow-off valve, 21-fractionation by adsorption still, 22-safety valve, 23-valve, 24-under meter, 25-T-valve)
Embodiment
Below embodiments of the invention are described, should be appreciated that embodiment described herein, only for description and interpretation the present invention, is not intended to limit the present invention.
Embodiment 1:
Apparatus of the present invention, removing the application in residual acetonitrile solvent in rapamycin, comprise the steps,
Open CO
2gas cylinder 1 and respective line valve 2,5,7,8,10,11,19,23, check that whether pipeline is unobstructed, closes after inspection; With the filter cloth of appropriate size, by untreated 20g rapamycin powder wrapped multilayer, filling is not located rapamycin powder, silica gel in desolventizing still 13, separating still 21 respectively, and silica gel is full of to separating still 21.Open air in vacuum pump 18 discharge systems; Set CO
2high-pressure pump 6 flows are 40L/h, open refrigeration plant I 4, II 9, after the temperature of refrigeration plant I 4, II 9 cooling fluids reaches design temperature-5 DEG C ,-10 DEG C, open CO
2high-pressure pump 6 and pipeline respective valves 2,5,7,8,10,11,19,23; CO
2gas cylinder 1 is discharged the CO with certain pressure
2by cleaner 3 purify, refrigeration plant I 4 is cooling, CO
2high-pressure pump 6 is pressurizeed, the cooling arrival desolventizing of refrigeration plant II 9 still 13, and desolventizing still 13 internal pressures rise to 25MP
atime, slowly Open valve 19, treats that pressure-stabilisation is at 25MP
atime, keep valve 19 apertures constant; Control desolventizing still 13 pressure (25MPa), temperature (10 DEG C) and CO
2flow (40L/h) is stabilized in set(ting)value, CO
2remove residual solvent in desolventizing still 13 in, open ultrasonic generator 15, continue 2.5h; The CO that desolventizing still 13 is discharged
2arrive separating still 21; CO
2in separating still 21 and residual acetonitrile solvent decompression separation, use silica gel adsorption residual acetonitrile solvent simultaneously; CO
2discharge separating still 21, after cleaner 3 purifies, recycle; Be disposed, first close CO
2high-pressure pump 6 and ultrasonic generator 15, then close CO
2gas cylinder outlet valve 2, after the interior demonstration pressure of desolventizing still 13 no longer declines, then valve-off 11 and valve 19, desolventizing still 13 is cut out separately from system pipeline; Open the blow-off valve 12 of desolventizing still 13, by the CO in desolventizing still 13
2slowly emptying, until tensimeter shows that pressure is 0MPa, then open the top kettle cover of desolventizing still 13; Taking-up is enclosed with the filter cloth of powder medicaments, after standing for some time, makes the complete sublimation separation of dry ice, opens filter cloth and collects medicine and preserve, desolventizing end of processing.
After having operated, drug powder after taking-up processing, preserves and samples detection.After testing, in the rapamycin powder after above art breading, the content of residual acetonitrile solvent is 0.007%, successful.
Embodiment 2:
Apparatus of the present invention, removing the application in residual acetone solvent in Everolimus, comprise the steps,
Load respectively untreated Everolimus powder (50g), silica gel in desolventizing still 13, separating still 21, with air in vacuum pump 18 discharge systems; CO
2gas cylinder 1 outlet pressure is about the CO of 5MPa
2successively by cleaner 3 purify, refrigeration plant I 4 cooling (to-5 DEG C), CO
2high-pressure pump 6 is pressurizeed, refrigeration plant II 9 temperature controls (to-20 DEG C) arrive desolventizing still 13; Control desolventizing still 13 pressure (25MPa), temperature (20 DEG C) and CO
2flow (40L/h) is stabilized in set(ting)value, CO
2remove residual acetone solvent 3h at desolventizing still 13, open ultrasonic generator 15 simultaneously; The CO that desolventizing still 13 is discharged
2arrive separating still 21, with residual acetone solvent decompression separation time, adsorb residual acetone solvent with sorbent material; The CO that separating still 21 is discharged
2after purifying, cleaner 3 recycles.
After having operated, drug powder after taking-up processing, preserves and samples detection.After testing, in the Everolimus powder after above art breading, residual acetone solvent is 0.033%, successful.
Embodiment 3:
Apparatus of the present invention, removing the application in residual acetonitrile solvent in Decitabine, comprise the steps,
Load respectively untreated Decitabine powder (30g), silica gel in desolventizing still 13, separating still 21, with air in vacuum pump 18 discharge systems; CO
2gas cylinder 1 outlet pressure is about the CO of 5MPa
2successively by cleaner 3 purify, refrigeration plant I 4 cooling (to-5 DEG C), CO
2high-pressure pump 6 is pressurizeed, refrigeration plant II 9 temperature controls (to-20 DEG C) arrive desolventizing still 13; Control desolventizing still 13 pressure (25MPa), temperature (10 DEG C) and CO
2flow (40L/h) is stabilized in set(ting)value, CO
2remove residual acetonitrile solvent 2.5h at desolventizing still 13, open ultrasonic generator 15 simultaneously; The CO that desolventizing still 13 is discharged
2arrive separating still 21, with residual acetonitrile solvent decompression separation time, adsorb residual acetonitrile solvent with sorbent material; The CO that separating still 21 is discharged
2after purifying, cleaner 3 recycles.
After having operated, drug powder after taking-up processing, preserves and samples detection.After testing, in the Decitabine powder after above art breading, residual acetonitrile solvent is 0.036%, successful.
Embodiment 4:
Apparatus of the present invention, removing the application in residual ethanol solvent in Temsirolimus, comprise the steps,
Load respectively untreated Temsirolimus powder (50g), silica gel in desolventizing still 13, separating still 21, with air in vacuum pump 18 discharge systems; CO
2gas cylinder 1 outlet pressure is about the CO of 5MPa
2successively by cleaner 3 purify, refrigeration plant I 4 cooling (to-5 DEG C), CO
2high-pressure pump 6 is pressurizeed, refrigeration plant II 9 temperature controls (to 0 DEG C) arrive desolventizing still 13; Control desolventizing still 13 pressure (25MPa), temperature (0 DEG C) and CO
2flow (40L/h) is stabilized in set(ting)value, CO
2remove residual ethanol solvent 2h at desolventizing still 13, open ultrasonic generator 15 simultaneously; The CO that desolventizing still 13 is discharged
2arrive separating still 21, with residual ethanol solvent decompression separation time, adsorb residual ethanol solvent with sorbent material; The CO that separating still 21 is discharged
2after purifying, cleaner 3 recycles.
After having operated, drug powder after taking-up processing, preserves and samples detection.After testing, in the Temsirolimus powder after above art breading, residual ethanol solvent is 0.003%, successful.
Claims (4)
1. a device that removes residual solvent in thermo-sensitivity solid pharmaceutical, is characterized in that: comprise CO
2gas cylinder 1, cleaner 3, refrigeration plant I 4, II 9, CO
2high-pressure pump 6, desolventizing still 13, fractionation by adsorption still 21, under meter 24 and multiple valve 2,5,7,8,10,11,12,16,17,19,20,22,23, described CO
2gas cylinder 1, cleaner 3, refrigeration plant I 4, CO
2high-pressure pump 6, refrigeration plant II 9, desolventizing still 13, fractionation by adsorption still 21, under meter 24 connect successively.
2. a kind of device that removes residual solvent in thermo-sensitivity solid pharmaceutical according to claim 1, is characterized in that, desolventizing still 13 internal pressures are that 10～40MPa, temperature are-20～0 DEG C.
3. a kind of device that removes residual solvent in thermo-sensitivity solid pharmaceutical according to claim 1, is characterized in that, installs ultrasonic transducer 14 in desolventizing still 13 additional, and each ultrasonic transducer 14 power are 30-800W, and preferably power is 100W; Resonant frequency is 20-100KHz, and preferably resonant frequency is 28 ± 2KHz.
4. a kind of device that removes residual solvent in thermo-sensitivity solid pharmaceutical according to claim 1, is characterized in that, on desolventizing still 13, line between ultrasonic transducer 14 and ultrasonic generator 15 is convenient in perforate, this hole epoxy sealing.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410158688.6A CN103922879A (en) | 2014-04-19 | 2014-04-19 | Device for removing residual solvents out of thermo-sensitive solid chemicals |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN201410158688.6A CN103922879A (en) | 2014-04-19 | 2014-04-19 | Device for removing residual solvents out of thermo-sensitive solid chemicals |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CN103922879A true CN103922879A (en) | 2014-07-16 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN201410158688.6A Pending CN103922879A (en) | 2014-04-19 | 2014-04-19 | Device for removing residual solvents out of thermo-sensitive solid chemicals |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104764813A (en) * | 2014-12-15 | 2015-07-08 | 青岛科技大学 | Kinetic rapid determination method for removing residual solvent in thermosensitive solid drug in virtue of high pressure CO2 |
| CN104931647A (en) * | 2015-04-09 | 2015-09-23 | 青岛科技大学 | Dynamical quick measuring device for desolventizing residual solvent in thermosensitive solid medicine in high-pressure CO2 (carbon dioxide) manner |
Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642632A (en) * | 2009-09-03 | 2010-02-10 | 江苏大学 | Subcritical liquid extraction device and subcritical liquid extraction method of active ingredients of natural products |
| CN102041164A (en) * | 2011-01-05 | 2011-05-04 | 南昌同心紫巢生物工程有限公司 | Ultrasonic-assisted tea oil extraction method using subcritical CO2 |
| WO2012056141A2 (en) * | 2010-10-29 | 2012-05-03 | Bernard Mompon | Method for producing articles of plant origin impregnated with a liquid plant substance |
| CN103361180A (en) * | 2013-07-18 | 2013-10-23 | 华南理工大学 | Extraction method of plant essential oil |
| CN103706145A (en) * | 2012-10-01 | 2014-04-09 | 青岛科技大学 | Subcritical CO2 based method used for low-temperature removing of residual solvents from thermal sensitive solid medicines |
| CN103877743A (en) * | 2014-03-20 | 2014-06-25 | 青岛科技大学 | Method for removing residual solvents from heat-sensitive solid drugs |
| CN103880576A (en) * | 2014-03-20 | 2014-06-25 | 青岛科技大学 | Device for desorbing residual solvent in thermo sensitivity solid medicine |
-
2014
- 2014-04-19 CN CN201410158688.6A patent/CN103922879A/en active Pending
Patent Citations (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101642632A (en) * | 2009-09-03 | 2010-02-10 | 江苏大学 | Subcritical liquid extraction device and subcritical liquid extraction method of active ingredients of natural products |
| WO2012056141A2 (en) * | 2010-10-29 | 2012-05-03 | Bernard Mompon | Method for producing articles of plant origin impregnated with a liquid plant substance |
| CN102041164A (en) * | 2011-01-05 | 2011-05-04 | 南昌同心紫巢生物工程有限公司 | Ultrasonic-assisted tea oil extraction method using subcritical CO2 |
| CN103706145A (en) * | 2012-10-01 | 2014-04-09 | 青岛科技大学 | Subcritical CO2 based method used for low-temperature removing of residual solvents from thermal sensitive solid medicines |
| CN103361180A (en) * | 2013-07-18 | 2013-10-23 | 华南理工大学 | Extraction method of plant essential oil |
| CN103877743A (en) * | 2014-03-20 | 2014-06-25 | 青岛科技大学 | Method for removing residual solvents from heat-sensitive solid drugs |
| CN103880576A (en) * | 2014-03-20 | 2014-06-25 | 青岛科技大学 | Device for desorbing residual solvent in thermo sensitivity solid medicine |
Non-Patent Citations (3)
| Title |
|---|
| 丁明磊: "低温亚临界CO2脱除热敏性药物溶残实验研究", 《万方全文数据库》, 25 February 2014 (2014-02-25) * |
| 张菁妤等: "低温使用聚氨酯改性环氧树脂密封胶的合成及性能", 《高分子材料科学与工程》, vol. 29, no. 9, 30 September 2013 (2013-09-30), pages 1 - 5 * |
| 张菁妤等: "低黏度耐超低温室温固化环氧树脂密封剂", 《中国胶粘剂》, vol. 22, no. 1, 31 January 2013 (2013-01-31) * |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104764813A (en) * | 2014-12-15 | 2015-07-08 | 青岛科技大学 | Kinetic rapid determination method for removing residual solvent in thermosensitive solid drug in virtue of high pressure CO2 |
| CN104931647A (en) * | 2015-04-09 | 2015-09-23 | 青岛科技大学 | Dynamical quick measuring device for desolventizing residual solvent in thermosensitive solid medicine in high-pressure CO2 (carbon dioxide) manner |
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Application publication date: 20140716 |