CN104271143A - Preventing or treating periodontal disease - Google Patents

Preventing or treating periodontal disease Download PDF

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Publication number
CN104271143A
CN104271143A CN201380018455.XA CN201380018455A CN104271143A CN 104271143 A CN104271143 A CN 104271143A CN 201380018455 A CN201380018455 A CN 201380018455A CN 104271143 A CN104271143 A CN 104271143A
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CN
China
Prior art keywords
applicator
oral surfaces
antimicrobial compositions
antimicrobial
methods according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN201380018455.XA
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Chinese (zh)
Inventor
R·皮耶尔加利尼
N·卢皮斯
S·拉斯托奇
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Klox Technologies Inc
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Klox Technologies Inc
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Filing date
Publication date
Priority claimed from US13/437,553 external-priority patent/US20120251981A1/en
Application filed by Klox Technologies Inc filed Critical Klox Technologies Inc
Publication of CN104271143A publication Critical patent/CN104271143A/en
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/17—Amides, e.g. hydroxamic acids having the group >N—C(O)—N< or >N—C(S)—N<, e.g. urea, thiourea, carmustine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61C—DENTISTRY; APPARATUS OR METHODS FOR ORAL OR DENTAL HYGIENE
    • A61C19/00—Dental auxiliary appliances
    • A61C19/06—Implements for therapeutic treatment
    • A61C19/063—Medicament applicators for teeth or gums, e.g. treatment with fluorides
    • A61C19/066—Bleaching devices; Whitening agent applicators for teeth, e.g. trays or strips
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/65—Tetracyclines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/40—Peroxides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K33/00—Medicinal preparations containing inorganic active ingredients
    • A61K33/42—Phosphorus; Compounds thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42—Amides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/02—Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/02—Local antiseptics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/87—Application Devices; Containers; Packaging

Abstract

The disclosure relates to a method for treating or preventing periodontal disease, such as gingivitis or periodontitis. The method may comprise providing an antimicrobial composition disposed within a reservoir, the reservoir being fluidly connected to an exterior surface of an applicator having a frictional stress value sufficient to cause mechanical displacement of a biofilm present on an oral cavity surface; dispensing said antimicrobial composition through said applicator onto said exterior surface of said applicator; applying the antimicrobial composition to the oral cavity surface; and rubbing said applicator onto said oral cavity surface and exerting pressure towards said oral cavity surface.

Description

The prevention of periodontal disease or treatment
Technical field
Present disclosure relates generally to prevention or treatment periodontal disease, specifically but non-uniquely relate to for preventing or treat device in the method for periodontal disease and purposes and antimicrobial compositions.
Background technology
If periodontal disease such as gingivitis and periodontitis untreated, can cause loss of tooth.Treatment needs dental clinic to go to a doctor usually.Therefore, there are the needs of the treatment that can the more conventional base outside dental clinic use.
Summary of the invention
Disclosed herein is for applying blast or the antimicrobial compositions apparatus and method for prevention or treatment periodontal disease to tooth and/or gingiva.This device is of portable form and can uses outside dental clinic.Preferably, certain friction stree is put on tooth and/or gingiva by this device.More preferably, this device applies friction stree value, and described friction stree value allows the biomembrane mechanical displacement that dental surface exists.Even more preferably, this device applies friction stree value, and described friction stree value allows the thin layer mechanical displacement that dental surface exists, but does not induce adamantine infringement.The blast for being combined with device and antimicrobial compositions disclosed in going back herein.In certain embodiments, the compositions of present disclosure has teeth whiter and antimicrobial acivity.Herein also disclosed in be method for preventing or treat periodontal disease, and antimicrobial compositions and device are for preventing or treat the purposes of periodontal disease.
In one aspect, the invention provides the device comprising the bank be connected with applicator fluid, this applicator has the friction stree value being enough to cause the biomembrane mechanical displacement that tooth and/or gingival surface exist.This applicator can comprise have diameter 0.1-1000 μm, usually but not necessarily with the hole that above-mentioned friction stree value is combined.Blast or antimicrobial compositions can be arranged in bank.In some embodiments, blast or antimicrobial compositions take scope as the amount existence of 2-6ml.This device can comprise and is configured to tooth blast or antimicrobial compositions to be assigned to the trigger applicator outer surface from bank.
In some embodiments, the outer surface of applicator has up to 4-100mm 2surface area.
In some embodiments, applicator comprises sponge.In some embodiments, applicator comprises silicone tip.In some embodiments, applicator comprises sponge, and sponge can comprise and has enough diameters and internuncial hole, is transported on the outer surface of sponge by sponge for by hydroxyapatite.
In some embodiments, blast or antimicrobial compositions comprise peroxide source.In some embodiments, blast or antimicrobial compositions comprise hydroxyapatite, and such as wherein hydroxyapatite has the particle diameter that scope is 10-200nm.
In yet another aspect, the invention provides the method for tooth blast.The method can comprise the steps: a) to provide the lightening composition be arranged in cylindrical bank, this cylindrical bank is connected with the outer surface fluid of applicator, described applicator has the friction stree value being enough to cause the biomembrane mechanical displacement that dental surface exists, or comprise the hole with diameter 0.1-1000 μm, or both, b) lightening composition is assigned on the outer surface of applicator by applicator, and c) lightening composition is applied on tooth.
In some embodiments, blast or antimicrobial compositions by rubbing applicator and apply pressure towards tooth and manually apply on tooth.
In further, present disclosure relates to and being used for the treatment of or the method for prevention of periodontal disease such as gingivitis or periodontitis.The method can comprise the steps: a) to provide the compositions be arranged in bank, this bank is connected with the outer surface fluid of applicator, described applicator has the friction stree value being enough to cause the biomembrane mechanical displacement that oral surfaces exists, or comprise the hole with diameter 0.1-1000 μm, or both, b) compositions is assigned on the outer surface of applicator by applicator, and c) compositions is applied on oral surfaces.In some embodiments, oral surfaces is tooth and/or gingiva.
In certain embodiments, to be used for the treatment of or the method for prevention of periodontal disease such as gingivitis or periodontitis comprises the compositions applying to comprise peroxide such as hydrogen peroxide and/or hydroxyapatite.Said composition can comprise antimicrobial such as antibiotic agent or antiviral agent.The exemplary antibiotic agent that can comprise in the composition comprises tetracycline, doxycycline, minocycline, amoxicillin and azithromycin.
In the method being used for the treatment of gingivitis or periodontitis, said composition can put on oral surfaces such as tooth and/or gingiva every day at least one times or weekly at least one times.In specific embodiments, said composition is put on gingiva and/or tooth/gingiva connecting portion.
According to another aspect, the invention provides the method for preventing or treat periodontal disease, described method comprises: provide the antimicrobial compositions be arranged in bank, this bank is connected with the outer surface fluid of applicator, and described applicator has the friction stree value being enough to cause the biomembrane mechanical displacement that oral surfaces exists; Described antimicrobial compositions is assigned on the described outer surface of described applicator by described applicator; Antimicrobial compositions is put on oral surfaces; And rub described applicator and apply pressure towards described oral surfaces on described oral surfaces.In certain embodiments, described oral surfaces rubs described applicator and towards described oral surfaces apply pressure while antimicrobial compositions is put on oral surfaces, before or after occur.The method can be included in and described oral surfaces rubs described applicator and towards after described oral surfaces applies pressure, new antimicrobial compositions put on the further step of oral surfaces.The applying of antimicrobial compositions can be used as the stream from bank to the compositions of bank outer surface.Described stream can be continuous or other modes.
According to another aspect, the invention provides the method for preventing or treat periodontal disease, described method comprises: make biomembrane mechanical displacement on an oral surface; And antimicrobial compositions is put on oral surfaces.In certain embodiments, apply antimicrobial compositions and comprise the exterior surface making oral surfaces and applicator, described applicator is connected with the bank fluid containing antimicrobial compositions.In certain embodiments, make biomembrane mechanical displacement comprise the described oral surfaces of friction and apply pressure with the outer surface of applicator towards described oral surfaces, the outer surface of applicator has the friction stree value being enough to the biomembrane mechanical displacement caused on oral surfaces.In certain embodiments, while making the biomembrane mechanical displacement on oral surfaces, before or after, antimicrobial compositions is put on oral surfaces.In certain embodiments, after making biomembrane be shifted, new antimicrobial compositions is put on oral surfaces.
In some embodiment in said method, antimicrobial compositions decomposes by the enzyme on oral surfaces or in saliva.Therefore, provide fresh antimicrobial compositions (described in provide can be continuous or be interrupted supply) can provide continuous antimicrobial effect to oral surfaces, described continuous antimicrobial effect can cause the more fast treating of periodontal disease or more effectively prevent.
In some embodiment in said method, oral surfaces is gingival surface, dental surface or gingival surface and dental surface.Gingival surface or dental surface can comprise periodontal pocket, and the method also can comprise and being pushed in periodontal pocket by antimicrobial compositions in said case.
In some embodiment in said method, antimicrobial compositions comprises peroxide source, and described peroxide source can be hydrogen peroxide or urea peroxide.
In some embodiment in said method, antimicrobial compositions comprises hydroxyapatite, and described hydroxyapatite can have the particle diameter that scope is 10-200nm.In certain embodiments, antimicrobial compositions comprises antibiotic agent, and described antibiotic agent can be selected from tetracycline, doxycycline, minocycline, amoxicillin and azithromycin.Antimicrobial compositions can comprise following in one or more: fluoride, triclosan, sodium bicarbonate, sweeting agent, detergent, chlorhexidine, cetyl pyridinium, stannous fluoride and amine fluoride.
In some embodiment in said method, antimicrobial compositions puts on oral surfaces every day at least one times or weekly at least one times.
In some embodiment in said method, the contact area between the outer surface and oral surfaces of applicator is about 0.25-400mm 2, about 4-100mm 2or about 9-25mm 2.The outer surface of applicator can have and is greater than about 0.001N/mm 2friction stree value.Applicator can comprise the hole with diameter 0.1-1000 μm.The outer surface of applicator can be made up of any suitable material or have and remove biomembranous any suitable texture for machinery.Such as, applicator can comprise sponge or silicone.The outer surface of applicator can comprise bristle.
According to further aspect, the invention provides antimicrobial compositions for preventing or treat the purposes of periodontal disease, wherein antimicrobial compositions is arranged in the bank that is connected with the outer surface fluid of applicator, described applicator is for being assigned to the outer surface of applicator by applicator by antimicrobial compositions, oral surfaces is put on for by antimicrobial compositions, when applicator outer surface is for oral surfaces friction and towards described oral surfaces applying pressure, the outer surface of described applicator has the friction stree value being enough to cause biomembrane mechanical displacement.
According to another aspect, the invention provides antimicrobial compositions on an oral surface for preventing or treat the purposes of periodontal disease, wherein with biomembrane mechanical displacement on an oral surface.Present invention also offers on oral surfaces that antimicrobial compositions has rupture biological film thereon for preventing or treat the purposes of periodontal disease.Present invention also offers and be used for the treatment of or the purposes of applicator of prevention of periodontal disease, wherein said applicator has the outer surface for antimicrobial compositions being put on oral surfaces applicator, and described outer surface has to be enough to cause the biomembrane mechanical displacement that oral surfaces exists or the friction stree value of breaking.In certain embodiments, antimicrobial compositions is arranged in the bank that is connected with the outer surface fluid of applicator, described applicator is for contacting oral surfaces so that antimicrobial compositions is put on oral surfaces, and described applicator has to be enough to cause the biomembrane mechanical displacement that oral surfaces exists or the friction stree value of breaking.
In some embodiment of such use, applicator and bank are arranged as while biomembrane mechanical displacement, before or after, antimicrobial compositions is delivered on the outer surface of applicator, to prevent or to treat periodontal disease.In some embodiment of such use, oral surfaces is gingival surface, dental surface or gingival surface and dental surface.
In some embodiment of such use, antimicrobial compositions comprises peroxide source such as urea peroxide.In some embodiment of such use, antimicrobial compositions comprises hydroxyapatite, and described hydroxyapatite can have the particle diameter that scope is 10-200nm.Antimicrobial compositions can comprise following in one or more: fluoride, triclosan, sodium bicarbonate, sweeting agent, detergent, chlorhexidine, cetyl pyridinium, stannous fluoride and amine fluoride.Antimicrobial compositions can comprise antimicrobial, and described antimicrobial can be antibiotic agent, such as tetracycline, doxycycline, minocycline, amoxicillin and azithromycin, or antiviral agent.
In some embodiment of such use, the contact area between the outer surface and oral surfaces of applicator is about 0.25-400mm 2, about 4-100mm 2or about 9-25mm 2.Applicator can have and is greater than about 0.001N/mm 2friction stree value.Applicator can comprise the hole with diameter 0.1-1000 μm.The outer surface of applicator can be made up of any suitable material or have and remove biomembranous any suitable texture for machinery.Such as, applicator can comprise sponge or silicone.The outer surface of applicator can comprise bristle.
In some embodiment in above-mentioned, antimicrobial compositions comprises urea peroxide, and reason is the ability that its generation could prevent or treat the reactive oxygen species of periodontal disease, and it is free from side effects.Especially, compared with hydrogen peroxide, the more difficult enzymatic degradation of urea peroxide, and tolerated better by oral mucosa.In addition, urea peroxide does not stain tooth, does not change taste, and not induced sensitivity, described sensitivity can occur for other antimicrobials such as chlorhexidine.
Accompanying drawing explanation
The further aspect of present disclosure and advantage will better be understood with reference to the description be combined with following accompanying drawing, in the drawing:
Fig. 1 shows the device for blast or antimicrobial compositions being put on tooth and/or gingiva.
Fig. 2 shows the device for blast or antimicrobial compositions being put on tooth and/or gingiva, and wherein said device has the applicator comprising sponge.
Fig. 3 describes the antibacterial activity of compositions in disk diffusion measurement.The antibacterial activity of compositions is compared with peroxide positive control and saline negative control.
Fig. 4 describes the suppression being fixed at the bacterial growth of disk perimeter in the survey of Fig. 3.
Detailed description of the invention
Present disclosure is not limited to described in following description or the structure of the component shown in accompanying drawing and the details of arrangement in its application.Present disclosure can have other embodiments and carry out in many ways putting into practice or performing.In addition, wording used herein and the object of term for describing, and should not be considered as restrictive." comprise ", " comprising " or " having ", " containing ", " relating to " and change use in this article thereof be intended to comprise the project and optional other project listed thereafter.When term "and/or" uses in this article, the particular content that two appointment features or component comprise or do not comprise another separately should be considered as.Such as, " A and/or B " should be considered as (i) A, (ii) B and (iii) A and B particular content separately, as setting forth individually in this article separately.In following description, same numbers is with reference to referring to similar components.In the accompanying drawings, same reference feature specifies same or similar part.
Apparatus and method
Described herein is device 10 and method for blast or antimicrobial compositions being put on tooth and/or gums.Preferred embodiment comprises the bank 25 be connected with applicator 30 fluid.Preferably, applicator is optimized with regard to its mechanical performance, to induce a certain friction stree on tooth and/or gingiva.The favourable selection of friction stree allows effective tooth blast or prevention or treatment periodontal disease, such as gingivitis or periodontitis, and does not damage the enamel of tooth or another part or gingiva.But friction stree should be enough to make biomembrane and/or thin layer (partly or entirely) from tooth and/or gingival surface mechanical displacement.As used herein, " thin film " is one deck sialoglycoprotein adhering to tooth and/or gingival surface.As used herein, " biomembrane " adheres to the surface of tooth and/or gingiva or the material of thin layer, and can comprise other component such as from the material of bacterial secretory.Such as, biomembrane can comprise the set group of cell, and the set group of described cell is derived from microorganism and is attached to substrate or each other.The cell of these attachments is imbedded in the substrate of the Extracellular Polymers type material that they have produced usually, and demonstrates the change phenotype with regard to rate of growth and genetic transcription.
Device 10 makes applicator 30 be placed in surface contact with tooth and/or gingiva, and tooth blast or antimicrobial compositions is delivered on the surface of tooth and/or gingiva by applicator 30.
Device 10 preferably has bank 25 for storing blast or antimicrobial compositions and the applicator 30 be connected with bank 25 fluid via feeder 42.Device 10 can be of portable form and with the shape of pencil, pen or liquid rod.In one embodiment, device 10 comprises the applicator 30 that removably can engage with device 10 more than.Device 10 is that in an embodiment as pen or pencil shape, applicator 30 can be retractible wherein.Blast described herein or antimicrobial compositions can directly be contained in the bank 25 of device 10, or can supply in the removable cartridge case (not shown) in bank 25, and described bank 25 is replaceable or recharge.This device also can comprise cap 45.
Think that the friction that the performance of applicator 30 with regard to tooth blast or antimicrobial acivity is passed through to be induced on tooth and/or gingiva by applicator 30 or wearing and tearing are enhanced.The friction of being induced on tooth and/or gingiva by applicator 30 or wearing and tearing can friction stree mode define.Friction stree value may be defined as the power applied reference surface/unit real contact area, and described friction stree value is expressed as σ=T/A=μ N/A.In this equation, T is tangential force, and A is contact area, and μ is coefficient of friction, and N is vertical force.
Not bound by theory, think the friction stree particular importance of applicator 30, because its instruction is transferred to the efficiency of tooth and/or gingival surface by the mechanical energy that user provides.Friction stree can cause biomembranous mechanical displacement.When applicator has low friction stree value, the energy supplied by user is otherwise such as dissipated by applicator self, thus causes applicator to be out of shape.
Be greater than 0.001N mm -2friction stree value be favourable.More preferably, friction stree value is 0.001-0.01N mm -2, 0.01-0.1N mm -2, 0.1-0.2N mm -2, 0.2-0.3N mm -2, 0.3-0.4N mm -2, 0.4-0.5N mm -2, 0.5-0.6N mm -2, 0.6-0.7N mm -2, 0.7-0.8N mm -2, 0.8-0.9N mm -2, or 0.9-1N mm -2.In certain embodiments, friction stree value can be 1-1.5N mm -2, 1.5-2N mm -2, or even 2-2.5 or 2.5-3N mm -2.
The friction stree value of applicator 30 can use methods known in the art to measure.An example uses handles chair (Plint) twin shaft reciprocating apparatus (such as model TE75R, MRPRA RUBBER CONSULTANTS).Device 10 clamps the loading arm of reciprocating apparatus, and device is suitable for relative to the angle of reference surface making the contact area of the outer surface of applicator 30 reach maximum.Clamp the consumer reality normal force N that arrangement should be set to provide about 3N on applicator 30.Coefficient of friction is measured subsequently between applicator 30 and reference surface, and described reference surface is similar to the surface of tooth and/or gingiva.Applicator 30 uses the blast as provided in example 1 or antimicrobial compositions to carry out wet measurement.Coefficient of friction both is measured through the center 10mm of four traversing 20mm at forward with oppositely with the speed of 1mm s-1, and calculating mean value.In the end use the measurement of applicator 30 in measuring position in triplicate, to check repeatability.
In some embodiments, applicator (such as 30) comprises sponge 40.Sponge 40 comprises the hole 41 be connected with feeder (such as 42) fluid, and described feeder receives blast from bank (such as 25) or antimicrobial compositions.Preferably, sponge 40 comprises and has the hole 41 that average diameter is about 0.1-1000 μm.More preferably, hole have about 0.1-100 μm, 100-200 μm, 200-300 μm, 300-500 μm, 500-750 μm or 750-1000 μm average diameter.
Sponge 40 can be made up of synthetic material or artificial material or natural material such as felt, foam, polyethylene, nylon, silicone etc.Preferably, sponge 40 is made up of the material of the erosion resistance to peroxide-induced.
In some embodiments, applicator comprises the sponge 40 of being made up of nylon such as flocking nylon.Fig. 2 shows the exemplary that wherein applicator comprises sponge 40.As shown in Figure 2, sponge 40 just has enough granules (such as hydroxy apatite particle, as described below) diameter and internuncial hole 41 be optimized, and described granule is treating that passing hole 41 is transported in blast on the outer surface of applicator 30 or antimicrobial compositions.The BrightOne (www.blancone.it) sold by international dentistry supply (International Dental Supply) comprises the sponge with above-mentioned feature.
Contact area between the outer surface of applicator 30 and tooth and/or gingival surface is preferably 0.25-400mm 2, 4-100mm 2or 9-25mm 2.This type of contact area guarantees that biomembranous optimal mechanical is removed, and allows blast or antimicrobial compositions to be effectively applied on the surface of tooth and/or gingiva.
The available dry applicator 30 of measurement of the contact area of applicator 30 outer surface carries out.Dry applicator 30 by following carry out moistening: described dry applicator 30 is pressed for the pad containing blast or antimicrobial compositions, and make device 10 clamp the loading arm handling chair twin shaft reciprocating apparatus (such as model TE75R, MRPRA RUBBER CONSULTANTS) subsequently.Labelling in the contact area of contact area representing applicator 30 outer surface obtains towards with the reduction and rising away from reference surface by controlling to handle chair loading arm.Device is suitable for making the contact area between applicator 30 and reference surface reach maximum relative to the angle of reference surface.Should be about 1 second time of contact, and the normal load of about 3N should be applied on bringing device.Calculating contact area can be carried out subsequently by the labelling average length using the magnifier with graticule to measure and width.The measurement of applicator 30 is used in triplicate, to check repeatability in final measuring position.
Via capillarity, such as in the flowing passing through pen, or by applying pressure by press device 10 on tooth and/or gingival surface to applicator 30, or such as there is via trigger mechanical piston, rotary knob and the ratchet mechanism of clicking mechanism, or button mechanism, or by airless injection method, or by compositions to be transferred to other machine tools of the oral surfaces needing treatment from bank 25, blast or antimicrobial compositions are assigned to the outer surface of applicator 30 from bank 25 by feeder 42 by device 10.On the first end that trigger can be positioned on device 10 or sidewall.
In certain embodiments, this device has the trigger comprising button.Use push-on starter, user's pressing is positioned at the button on the first end of device 10 or sidewall, and this causes compositions to be transferred to the outer surface of applicator 30 from bank 25 by feeder 42.More preferably, push-on starter has the arrangement allowing lightening composition to separate.This can such as realize via the padlock shut-down mechanism be connected with push-on starter.According to the sound of padlock after start button trigger, user can recognize that the blast of single dose or antimicrobial compositions have been assigned on the outer surface of applicator 30.
Once compositions is positioned on the outer surface of applicator 30, user just passes through at tooth and/or gingiva left-hand seat dynamic friction applicator 30 and applies pressure towards tooth and/or gingiva, compositions is put on tooth and/or gingival surface.Preferably, apply pressure towards tooth and/or gingiva cause biomembranous mechanical displacement from tooth and/or gingival surface at tooth and/or gingiva left-hand seat dynamic friction applicator 30.
User's one group of instruction can be supplied to how the compositions from device 10 is applied on tooth and/or gingiva to describe.
In certain embodiments, bank 25 is made up of peroxide resistant material.In one embodiment, bank 25 is prepared by this base polymer that the composition components of fluoropolymer, polypropylene, polyethylene or other and present disclosure is compatible.
Compositions
The device of present disclosure can be used for multiple combination thing to be delivered to tooth and gingiva especially.In some embodiments, this device is sent blast tooth and/or is had the compositions of antimicrobial property.Compositions described herein can be used for treating periodontal disease, such as gingivitis or periodontitis.The compositions with antimicrobial acivity also can have teeth whiter activity.
Term " prevention " is that field is generally acknowledged, and when about disease such as periodontal disease such as periodontitis use, that this area is fully understood, and comprise using of compositions, relative to the experimenter not accepting compositions, described compositions reduces the frequency of the medical conditions symptom in experimenter, or postpones the outbreak of the medical conditions symptom in experimenter.Therefore, the prevention of periodontitis comprises such as relative to untreated control population, reduces and support the ligament of tooth and the inflammation of bone or infection in the PATIENT POPULATION accepting prophylactic treatment.
Term " prevention " treatment is that field is generally acknowledged, and refers to medicine using host.If it uses before the clinical manifestation of undesirable disease (disease of such as host animal or other undesirable states), then treatment is prevention, and namely it protects host not develop undesirable disease.
" treatment " disease or disease refer at least one symptom curing and improve disease or disease.
At least one brightener that compositions used herein comprises gel carrier and disperses everywhere at gel carrier.Brightener or antimicrobial are dissolvable in water in gel carrier, or in the carrier dispersed as insoluble suspended solids simply.
Said composition can comprise peroxide source.Hydrogen peroxide is strong oxidant.Usually, the concentration of hydrogen peroxide in the present composition for be about 0.001-10% by composition weight meter, such as 1-7% or 4-6%.Also can use perhydrit (also referred to as urea peroxide, Carbamaid peroxide or percarbamide).Usually, the urea peroxide concentration in the present composition for be about 0.003-30% by composition weight meter, such as about 1-25%, 10-20% or 13-17%.Said composition can comprise bicarbonate such as sodium bicarbonate.
Gel carrier can contain the composition of any number, and described composition increases the viscosity of compositions and can scope be the amount existence being about 35-95% or 45-70% or 55-65% by composition weight meter.In certain embodiments, add enough gel carriers and have about 10,000 to 200,000cps or about 30 to obtain, the compositions of the viscosity of 000 to 150,000 or 50,000 to 120,000.Gel carrier can comprise one or more polymer.Preferred polymers be acrylic acid heavy polymer such as gel carrier also can comprise cellulose derivative (such as hydroxyethyl-cellulose, sodium carboxymethyl cellulose and methylcellulose), glue (such as sodium alginate, carrageenin, xanthan gum, Tragacanth, arabic gum, gellan gum (jellan gum) and natural gellan gum), composite adhesives (such as polyvinyl alcohol, CVP Carbopol ETD2050, polyvinylpyrrolidone, propylene glycol and polyethylene glycol oxide), natural polyols (such as glycerol, mannitol, Sorbitol and maltose alcohol) and inorganic bond (such as silica gel, aluminum silica gel, propolis and hectorite).Such as, gel carrier can contain the polymer combined with composite adhesives and/or natural polyols, such as 12-18% composite adhesives (such as propylene glycol), 40-50% natural polyols (such as glycerol) and 0.5-4% polymer (such as carbomer).
In some embodiments, said composition comprises flavoring agent.Useful flavoring agent comprises aromatic oil and multi-condiment aldehyde, ester, alcohol and analog material.The example of aromatic oil comprises Oleum Menthae Rotundifoliae, Oleum menthae, wintergreen oil, Sassafras oil, Oleum Caryophylli, sage oil, Eucalyptus oil, Majorana hortensis oil, Oleum Cinnamomi, Fructus Citri Limoniae oil, lime oil, oil of grapefruit and orange oil.Also usefully this type of chemicals such as menthol, carvone and anethole, and mixed condiments is as the derivant of Evercool and ring-type alpha-keto-enamine.In these, the most frequently used is Oleum menthae, Oleum Menthae Rotundifoliae and wintergreen oil.Flavoring agent is to mix in the blast fluid composition of present disclosure by the concentration of composition weight meter about 0.05 to about 2% or preferred about 0.1 to about 0.5%.Sweet material also can be used as supplementing of seasoning material.Suitable sweeting agent is water miscible and comprises saccharin sodium, Sodium Cyclamate, xylitol, Folium Perillae (perillartien), D-trp, aspartame, dihydrochalcone etc.
In some embodiments, said composition comprises blast granule.Blast granule can comprise calcium phosphate form.Calcium phosphate can have and is selected from tetracalcium phosphate, amorphous calcium phosphate, type alpha tricalcium phosphate, bata-tricalcium phosphate and hydroxyapatite (Ca 5(OH) (PO 4) 3) structure.Calcium phosphate can be the insoluble calcium phosphate of aqueous and noncrystalline, weak crystallization substantially or crystal form such as crystalline hydroxyapatite.Preferably, said composition comprises the nano-particle of hydroxyapatite.
Hydroxyapatite has the physical arrangement similar to enamel, and therefore has the strong affinity with enamel surface, thus causes hydroxy apatite particle enamel surfaces being given to " natural " white appearance.Owing to passing through sponge applied pressure and friction, hydroxyapatite crystal also can cause the accumulation of electrostatic charge, thus promotes and expand the ion penetration in enamel structure.A large amount of hydroxyapatite nanoparticles even can be oozed out in enamel, and promotes calcium and the calcium phosphate ion deposition on enamel.Hydroxyapatite also can reduce the illeffects of peroxide, and allows the remineralization of enamel.Preferably, hydroxyapatite is present in the compositions of present disclosure with the concentration being about 0.5-5% or about 1-2% by composition weight meter.In some embodiments, hydroxy apatite particle can comprise the aggregation of indivedual hydroxy apatite particle.Such as, this type of aggregation can have about 100nm to the average diameter of about 1000nm, and comprises and have the hydroxy apatite particle of about 10nm to about 200nm average diameter.
In some embodiments, said composition also comprise following in one or more: fluoride, triclosan, detergent, chlorhexidine, cetyl pyridinium, stannous fluoride and amine fluoride.The example of amine fluoride comprises olaflur (N '-octadecyltrimethylen-iamine-N, N, N '-three (2-ethanol)-dihydrofluoride) and dectaflur (9-octadecylene base amine hydrofluoride).Exemplary detergents comprises delmopinol, sodium lauryl sulphate (SLS) and cocamidopropyl betaine (CAPB).
In certain embodiments, said composition also comprises antimicrobial.Such as, antimicrobial can be selected from antiviral agent or antibiotic agent.Antibiotic comprises such as vancomycin, penicillin, amoxicillin, ampicillin, cefotaxime, ceftriaxone, cefixime, rifampicin metronidazole, doxycycline, tetracycline, minocycline, azithromycin, tacrolimus, cyclosporin, sirolimus, everolimus, ascosin, erythromycin, clarithromycin, clindamycin, lincomycin, dirithromycin, josamycin, spiramycin, diacetyl midecamycin, tylosin, Roxithromycin, ABT-773, Ketek, kitasamycin, lincosamide, dactinomycin, daunorubicin, doxorubicin, idarubicin, anthracene nucleus, mitoxantrone, bleomycin, plicamycin, mitomycin and streptomycin.
In some embodiments, said composition comprises stabilizing agent.The stabilizing agent utilized in aqueous gel exists with the amount by aqueous gel weighing scale about 0.01% to about 5%.The amount of about 1% stabilizing agent is preferred.Stabilizing agent is selected from amino carboxylic acid and salt thereof usually.Preferred stabilizing agent is selected from amino carboxylic acid and its alkali metal salt and/or alkali salt.Suitable amino carboxylic acid comprises anti-form-1,2-cyclohexalene two nitrilo-tetraacethyl (CDTA), ethylenediaminetetraacetic acid (EDTA), N-(2-ethoxy) ethylenediamine triacetic acid (HEDTA), nitrilotriacetic acid(NTA) (NTA), diethylene-triamine pentaacetic acid (DTPA), triethylenetetramine hexaacetic acid (TTHA) and ethyleneglycolbis(2-aminoethylether)tetraacetic acid (GEDTA).
In addition to the above components, neutralization reagent can add in compositions.Adoptable inorganic neutralization reagent and organic neutralization reagent are alkali.Suitable alkali comprises alkali metal hydroxide and ammonium hydroxide, carbonate, alkoxide, oxide, peroxide, superoxides and water-soluble organic amine.Aminoacid such as Beta-alanine and lysine also can be used for neutralization and viscosity is modified.Preferred alkali comprises sodium hydroxide, potassium hydroxide, ammonium hydroxide, triethanolamine (TEA), aminomethylpropanol (AMP), TRIS (trometamol), tetrahydroxypropyl ethylenediamine and three (methylol) aminomethane (TRIS).In certain embodiments, neutralization reagent will be used for obtaining the lightening composition of the pH with about 4 to 10 or about 5 to 7 or about 5.5 to 6.5.
Following is the aspect of present disclosure and the non-limiting example of embodiment.
Embodiment 1
Exemplary composition is prepared by mixing following component.
Component % content
Propylene glycol ≈16％
Pure water ≈18％
Glycerol ≈45％
Carbamaid peroxide ≈15％
EDETATE SODIUM ≈1％
Acritamer 940 ≈2％
Sodium hydroxide ≈0.5％
Nanocrystal hydroxyapatite ≈1.5％
Saccharin sodium ≈0.1％
Mint flavor ≈0.2％
Embodiment 2
Use the antibacterial activity of disk diffusion measurement evaluation group compound.
With from gingiva tooth connecting portion Fresh bacterial inoculating nutrient medium and at 37 DEG C with stir cultivate.After 24 hours, 500 μ L bacterial suspensions are spread on agar plates, and 8mm sterile nylon disk is placed on plate.By 15 μ L test solution (saline, 1%H 2o 2and 4.3%H 2o 2) or the compositions of 500 μ L embodiments 1 be applied on disk, and make plate incubation 24 hours at 37 DEG C.As shown in Figures 3 and 4, as by disk perimeter without shown in the diameter of cingula, the compositions of embodiment 1 is to the clear and definite bactericidal activity of bacteria display from gingiva tooth connecting portion.
Be to be understood that present disclosure is not limited to the particular describing and illustrate herein, but all modifications comprised within the scope of the present disclosure that falls into and define as claims and change.

Claims (83)

1., for preventing or treat a method for periodontal disease, described method comprises:
There is provided the antimicrobial compositions be arranged in bank, described bank is connected with the outer surface fluid of applicator, and described applicator has the friction stree value being enough to cause the biomembrane mechanical displacement that oral surfaces exists;
Described antimicrobial compositions is assigned on the described outer surface of described applicator by described applicator;
Described antimicrobial compositions is put on described oral surfaces; With
Described oral surfaces rubs described applicator and apply pressure towards described oral surfaces.
2. method according to claim 1, wherein rub described applicator and apply pressure towards described oral surfaces and occur while described antimicrobial compositions is put on described oral surfaces on described oral surfaces.
3. method according to claim 1, wherein rub described applicator and apply pressure towards described oral surfaces and occurred before described antimicrobial compositions is put on described oral surfaces on described oral surfaces.
4. method according to claim 1, wherein rub described applicator and apply pressure towards described oral surfaces and occur after described antimicrobial compositions is put on described oral surfaces on described oral surfaces.
5. the method according to any one of claim 1-4, described method is also included in and described oral surfaces rubs described applicator and towards after described oral surfaces applies pressure, new antimicrobial compositions put on the step of described oral surfaces.
6. the method according to any one of claim 1-5, wherein said oral surfaces is gingival surface, dental surface or gingival surface and dental surface.
7. method according to claim 6, wherein said gingival surface or dental surface comprise periodontal pocket, and described method also comprises and being pushed in described periodontal pocket by described antimicrobial compositions.
8. the method according to any one of claim 1-7, wherein said antimicrobial compositions comprises peroxide source.
9. method according to claim 8, wherein said peroxide source is urea peroxide.
10. the method according to any one of claim 1-9, wherein said antimicrobial compositions comprises hydroxyapatite.
11. methods according to claim 10, wherein said hydroxyapatite has the particle diameter that scope is 10-200nm.
12. methods according to any one of claim 1-11, wherein said antimicrobial compositions comprises antimicrobial.
13. methods according to claim 12, wherein said antimicrobial is antibiotic agent.
14. methods according to claim 13, wherein said antibiotic agent is selected from tetracycline, doxycycline, minocycline, amoxicillin and azithromycin.
15. methods according to claim 12, wherein said antimicrobial is antiviral agent.
16. methods according to any one of claim 1-15, wherein said antimicrobial compositions comprise following in one or more: fluoride, triclosan, sodium bicarbonate, sweeting agent, detergent, chlorhexidine, cetyl pyridinium, stannous fluoride and amine fluoride.
17. methods according to any one of claim 1-16, wherein said compositions is applied to described oral surfaces every day at least one times.
18. methods according to any one of claim 1-16, wherein said compositions is applied to described oral surfaces weekly at least one times.
19. methods according to any one of claim 1-18, the contact area wherein between the outer surface and described oral surfaces of described applicator is about 0.25-400mm 2, about 4-100mm 2or about 9-25mm 2.
20. methods according to any one of claim 1-19, wherein said applicator has and is greater than about 0.001N/mm 2friction stree value.
21. methods according to any one of claim 1-20, wherein said applicator comprises the hole with diameter 0.1-1000 μm.
22. methods according to any one of claim 1-21, the outer surface of wherein said applicator comprises bristle.
23. 1 kinds for preventing or treat the method for periodontal disease, described method comprises:
Make biomembrane mechanical displacement on an oral surface; With
Antimicrobial compositions is put on described oral surfaces.
24. methods according to claim 23, wherein apply described antimicrobial compositions and comprise the exterior surface making described oral surfaces and applicator, and described applicator is connected with the bank fluid containing described antimicrobial compositions.
25. methods according to claim 24, wherein make described biomembrane mechanical displacement comprise the described oral surfaces of friction and apply pressure with the outer surface of described applicator towards described oral surfaces, the outer surface of described applicator has the friction stree value being enough to the biomembrane mechanical displacement caused on described oral surfaces.
26. methods according to any one of claim 23-25, wherein while making the biomembrane mechanical displacement on described oral surfaces, put on described oral surfaces by described antimicrobial compositions.
27. methods according to any one of claim 23-25, wherein before making the biomembrane mechanical displacement on described oral surfaces, put on described oral surfaces by described antimicrobial compositions.
28. methods according to any one of claim 23-25, wherein after making the biomembrane mechanical displacement on described oral surfaces, put on described oral surfaces by described antimicrobial compositions.
29. methods according to any one of claim 23-25, wherein described antimicrobial compositions is put on the stream that described oral surfaces comprises described antimicrobial compositions and be fed to applicator from bank, described applicator rubs on described oral surfaces.
30. methods according to any one of claim 23-29, wherein said oral surfaces is gingival surface, dental surface or gingival surface and dental surface.
31. methods according to claim 30, wherein said gingival surface or dental surface comprise periodontal pocket, and described method also comprises and being pushed in described periodontal pocket by described antimicrobial compositions.
32. methods according to any one of claim 23-30, wherein said antimicrobial compositions comprises peroxide source.
33. methods according to claim 32, wherein said peroxide source is urea peroxide.
34. methods according to any one of claim 23-33, wherein said antimicrobial compositions comprises hydroxyapatite.
35. methods according to claim 34, wherein said hydroxyapatite has the particle diameter that scope is 10-200nm.
36. methods according to any one of claim 23-35, wherein said antimicrobial compositions comprises antimicrobial.
37. methods according to claim 36, wherein said antimicrobial is antibiotic agent.
38. according to method according to claim 37, and wherein said antibiotic agent is selected from tetracycline, doxycycline, minocycline, amoxicillin and azithromycin.
39. methods according to claim 36, wherein said antimicrobial is antiviral agent.
40. methods according to any one of claim 23-39, wherein said antimicrobial compositions comprise following in one or more: fluoride, triclosan, sodium bicarbonate, sweeting agent, detergent, chlorhexidine, cetyl pyridinium, stannous fluoride and amine fluoride.
41. methods according to any one of claim 23-40, wherein said antimicrobial compositions is applied to the biomembrane of described oral surfaces and displacement every day at least one times.
42. methods according to any one of claim 23-40, wherein said antimicrobial compositions is applied to weekly the biomembrane of described oral surfaces and displacement at least one times.
43. methods according to any one of claim 24-42, wherein said applicator comprises the hole with diameter 0.1-1000 μm.
44. methods according to any one of claim 24-43, the outer surface of wherein said applicator comprises bristle.
45. methods according to any one of claim 24-44, the contact area wherein between the outer surface and described oral surfaces of described applicator is about 0.25-400mm 2, about 4-100mm 2or about 9-25mm 2.
46. methods according to any one of claim 24-45, the outer surface of wherein said applicator has and is greater than about 0.001N/mm 2friction stree value.
47. 1 kinds of antimicrobial compositions are for preventing or treat the purposes of periodontal disease, wherein said antimicrobial compositions is arranged in the bank that is connected with the outer surface fluid of applicator, described applicator is for being assigned to the outer surface of described applicator by described applicator by described antimicrobial compositions, described oral surfaces is put on for by described antimicrobial compositions, when described applicator outer surface is for described oral surfaces friction and towards described oral surfaces applying pressure, the outer surface of described applicator has the friction stree value being enough to cause described biomembrane mechanical displacement.
48. purposes according to claim 47, wherein said applicator and bank be arranged as to rub on described oral surfaces described applicator outer surface and execute stressed towards described oral surfaces while, described antimicrobial compositions is delivered on the outer surface of described applicator, to prevent or to treat periodontal disease.
49. purposes according to claim 47, wherein said applicator and bank are arranged as and on described oral surfaces, rub described applicator outer surface and before applying pressure towards described oral surfaces, described antimicrobial compositions is delivered on the outer surface of described applicator, to prevent or to treat periodontal disease.
50. purposes according to claim 47, wherein said applicator and bank are arranged as the described applicator outer surface and towards after described oral surfaces applies pressure of rubbing on described oral surfaces, described antimicrobial compositions is delivered on the outer surface of described applicator, to prevent or to treat periodontal disease.
51. purposes according to any one of claim 47-50, wherein said oral surfaces is gingival surface, dental surface or gingival surface and dental surface.
52. purposes according to any one of claim 47-51, wherein said antimicrobial compositions comprises peroxide source.
53. purposes according to claim 52, wherein said peroxide source is urea peroxide.
54. purposes according to any one of claim 47-53, wherein said antimicrobial compositions comprises hydroxyapatite.
55. purposes according to claim 54, wherein said hydroxyapatite has the particle diameter that scope is 10-200nm.
56. purposes according to any one of claim 47-55, wherein said antimicrobial compositions comprises antimicrobial.
57. purposes according to claim 56, wherein said antimicrobial is antibiotic agent.
58. purposes according to claim 57, wherein said antibiotic agent is selected from tetracycline, doxycycline, minocycline, amoxicillin and azithromycin.
59. purposes according to claim 56, wherein said antimicrobial is antiviral agent.
60. purposes according to any one of claim 47-59, wherein said antimicrobial compositions comprise following in one or more: fluoride, triclosan, sodium bicarbonate, sweeting agent, detergent, chlorhexidine, cetyl pyridinium, stannous fluoride and amine fluoride.
61. purposes according to any one of claim 47-60, the contact area wherein between the outer surface and described oral surfaces of described applicator is about 0.25-400mm 2, about 4-100mm 2or about 9-25mm 2.
62. purposes according to any one of claim 47-61, wherein said applicator has and is greater than about 0.001N/mm 2friction stree value.
63. purposes according to any one of claim 47-62, wherein said applicator comprises the hole with diameter 0.1-1000 μm.
64. purposes according to any one of claim 47-63, wherein said applicator comprises bristle.
65. antimicrobial compositions on an oral surface for preventing or treat the purposes of periodontal disease, wherein with the mechanical displacement of biomembrane on described oral surfaces.
66. purposes according to claim 65, wherein said antimicrobial compositions is arranged in the bank that is connected with the outer surface fluid of applicator, described applicator is for contacting described oral surfaces so that described antimicrobial compositions is put on described oral surfaces, and described applicator has the friction stree value being enough to cause the biomembrane mechanical displacement that described oral surfaces exists.
67. purposes according to claim 66, wherein said applicator and bank are arranged as while making described biomembrane be shifted, and are delivered to by described antimicrobial compositions on the outer surface of described applicator, to prevent or to treat periodontal disease.
68. purposes according to claim 66, wherein said applicator and bank were arranged as before making the displacement of described biomembrane, were delivered to by described antimicrobial compositions on the outer surface of described applicator, to prevent or to treat periodontal disease.
69. purposes according to claim 66, wherein said applicator and bank are arranged as after making the displacement of described biomembrane, are delivered to by described antimicrobial compositions on the outer surface of described applicator, to prevent or to treat periodontal disease.
70. purposes according to any one of claim 65-69, wherein said oral surfaces is gingival surface, dental surface or gingival surface and dental surface.
71. purposes according to any one of claim 65-70, wherein said antimicrobial compositions comprises peroxide source.
72. according to the purposes described in claim 71, and wherein said peroxide source is urea peroxide.
73. purposes according to any one of claim 65-72, wherein said antimicrobial compositions comprises hydroxyapatite.
74. according to the purposes described in claim 73, and wherein said hydroxyapatite has the particle diameter that scope is 10-200nm.
75. purposes according to any one of claim 65-74, wherein said antimicrobial compositions comprises antimicrobial.
76. according to the purposes described in claim 75, and wherein said antimicrobial is antibiotic agent.
77. according to the purposes described in claim 76, and wherein said antibiotic agent is selected from tetracycline, doxycycline, minocycline, amoxicillin and azithromycin.
78. according to the purposes described in claim 75, and wherein said antimicrobial is antiviral agent.
79. purposes according to any one of claim 65-78, wherein said antimicrobial compositions comprise following in one or more: fluoride, triclosan, sodium bicarbonate, sweeting agent, detergent, chlorhexidine, cetyl pyridinium, stannous fluoride and amine fluoride.
80. purposes according to any one of claim 66-79, the contact area wherein between the outer surface and described oral surfaces of described applicator is about 0.25-400mm 2, about 4-100mm 2or about 9-25mm 2.
81. purposes according to any one of claim 66-80, wherein said applicator has and is greater than about 0.001N/mm 2friction stree value.
82. purposes according to any one of claim 66-81, wherein said applicator comprises the hole with diameter 0.1-1000 μm.
83. purposes according to any one of claim 66-82, wherein said applicator comprises bristle.
CN201380018455.XA 2012-04-02 2013-04-02 Preventing or treating periodontal disease Pending CN104271143A (en)

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