CN1043406C

CN1043406C - Method for preparation of compound Qingdaisan powder

Info

Publication number: CN1043406C
Application number: CN93121590A
Authority: CN
Inventors: 尚庆英
Original assignee: Individual
Current assignee: Individual
Priority date: 1993-12-27
Filing date: 1993-12-27
Publication date: 1999-05-19
Anticipated expiration: 2013-12-27
Also published as: CN1094964A

Abstract

The present invention relates to compound qingdaisan which is prepared from nine Chinese herbal medicines, wherein alkaloids with effective curative effects of common cnidium fruit, golden thread, lightyellow sophora root, golden larch bark and folium syringae are extracted by different methods. After being crushed and sieved, calcined alum, catechu, realgar and bear gall are mixed with the alkaloids, sieved, dried, sterilized and packed in a separate way; then, the compound qingdaisan is prepared. The compound qingdaisan is used for treating various kinds of vaginitis and trachelitis of females; the females with diseases need adopting a drug powder applying device for cervixes offered in the China patent with the patent number of 92200616.4 to spray the medicine powder on uterine necks and in vaginae. Excipients do not need adding to the medicine, so the medicine of the present invention is favorable for realizing the curative effects.

Description

The preparation method of compound Qingdaisan powder

The present invention is a kind of preparation method of Chinese herb medicine, is the process for preparing medicine that is used for the treatment of female vagina and cervicitis.

At present, the medicine of treatment female vagina and cervicitis mainly contains two classes, and a class is that medicine is made suppository, and another kind of is that medicine is made tablet, is used to the intravaginal filling by patient.This two classes pharmaceutical dosage form all needs to add excipient, and the therapeutic component that these excipient influence in the medicine directly contacts with the inflammation wound surface, thereby has reduced the curative effect of therapeutic component, and easily pollutes underwear again.

The present invention designs for the effect that improves treatment female vagina and cervicitis.

According to tcm theory, female vagina and cervicitis are referred to as " leukorrheal diseases ", and the traditional Chinese medical science is thought: " leukorrheal diseases " main diseases is because of being: " invade in the damp, accumulate and give birth to heat.Chinese medicine to the Therapeutic Principle of " leukorrheal diseases " is: based on damp eliminating, and the suitable heat-clearing and toxic substances removing of holding concurrently.To have cervix uteri to waste mashed more in view of patient, the vulva pruritus symptom, and clinical experience proves, adds Chinese medicinal herbs with removing the necrotic tissue and promoting granulation, the Chinese crude drug of holding back wound and killing parasites for relieving itching, can strengthen therapeutic effect.

The technology of the present invention solution:

The present invention is made up of following Chinese medicinal herbs: Fructus Cnidii, Rhizoma Coptidis, Radix Sophorae Flavescentis, Cortex Pseudolaricis, Folium Caryophylli, dry Alumen, CATECHU, Realgar, Fel Ursi.

The present invention prepares as follows:

The first step: Fructus Cnidii and Folium Caryophylli adopt water to do the leaching solvent respectively, adopt infusion process, and decocting method or percolation will be condensed into thick paste (1) after the leachate filtration.Rhizoma Coptidis and Radix Sophorae Flavescentis adopt water to add the acid adjuvant that leaches respectively and do the leaching solvent, heating extraction, and extracting liquid filtering, adding alkali adjustment filtrate pH value such as calcium carbonate or sodium hydroxide is 7, leaves standstill a few hours, is condensed into thick paste (2) and (3) after filtering once more.Cortex Pseudolaricis as leaching solvent, adopts infusion process or hot infusion process with 40-80% ethanol, and after leachate filtered, the ethanol with in the way of distillation recovery filtrate was condensed into leachate thick paste (4) again.

Second step: after above-mentioned thick paste (1), (2), (3), (4) mixing, can adopt hypobaric drying method, medicated powder A is pulverized, is screened into to thermal vapor stream seasoning or freeze-drying drying.Dry Alumen, CATECHU and Realgar mix the back pulverizes, and is screened into medicated powder B.Fel Ursi is ground into fine powder, and the back of sieving becomes medicated powder C.

The 3rd step:, adopt eo sterilization method, far infrared sterilization or Co with medicated powder A, B, the mutual mix homogeneously of C ⁶⁰The radiation sterilization sterilization all can.

Ill women can adopt China's No. 92200616.4 patents---drug powder applying device for cervix, directly sprays on the cervix uteri compound Qingdaisan powder and intravaginal, also can spray on the cervix uteri compound Qingdaisan powder and intravaginal by other people.

Adopt the present invention to treat female vagina and cervicitis is obtained following good effect: not add on the compound Qingdaisan powder of any excipient on cervix uteri and after on the intravaginal inflammatory wound surface, can contact with whole inflammatory wound surface immediately, can bring into play the anti-inflammation of medicine rapidly fully, promote the effect of planing surface healing.Nine flavor Chinese medicinal herbs pharmacological action complementations have increased antibacterial range, have strengthened antibiotic parasiticidal effect, have removing the necrotic tissue and promoting granulation again, hold back the effect of wound, have improved the scorching and various colpitic therapeutic effect of woman cervix uteri significantly.

The embodiment of the invention:

One, take off and state Chinese medicinal herbs, can prepare by following proportioning:

Fructus Cnidii 200kg Rhizoma Coptidis 150kg Radix Sophorae Flavescentis 200kg Cortex Pseudolaricis 100kg

Folium Caryophylli 100kg dry Alumen 10kg CATECHU 8kg Realgar 6kg

Fel Ursi 2kg

Two, compound Qingdaisan powder preparation method:

The first step: Fructus Cnidii and Folium Caryophylli add water 8-10 doubly, decoct twice, decoct 40-10 minute at every turn, and gradation filters, merging filtrate, and filtrate is concentrated into relative density and is: the thick paste of 1.20-1.25 (1).Add 8-10 after the Radix Sophorae Flavescentis fragmentation and doubly measure 0.2% sulfuric acid solution, heating extraction twice, each about 1 hour, merging filtrate was 7 with 10% sodium hydroxide solution adjust pH, left standstill 2 hours, filtered, filtrate is concentrated into the thick paste that relative density is 1.20-1.25 (2).Add the 0.1 % citric acid soln that 8-10 doubly measures after the Rhizoma Coptidis fragmentation, heating extraction twice, each about 1 hour, merging filtrate, using calcium carbonate or sodium hydroxid adjustment pH value is 7, leaves standstill 2 hours, filter, it is 1.12-1.22 thick paste (3) that filtrate is concentrated into relative density.Add 5 times of amount 75% alcoholic solution after the Cortex Pseudolaricis shredding, put in 40 ℃ of hot water lixiviate 48 hours, incline and get supernatant, residue adds doubly 75% ethanol of 1-2 again, put in 40 ℃ of hot water lixiviate 48 hours, and filtered, filtrate and the merging of above-mentioned supernatant, reclaim ethanol to there not being the alcohol flavor with the way of distillation, be condensed into the thick paste that relative density is 1.20-1.25 (4).

Second step: after above-mentioned thick paste (1), (2), (3), (4) mixing, adopt the hypobaric drying method drying, pulverize, cross 100 mesh sieves, become medicated powder A.Dry Alumen, CATECHU and Realgar mix the back pulverizes, and crosses 100 mesh sieves, becomes medicated powder B.Fel Ursi is ground into fine powder, crosses 100 mesh sieves, becomes medicated powder C.

The 3rd step: with medicated powder A, B, the mutual mix homogeneously of C, put in 80 ℃ of far infrared casees, dry sterilization 2 hours is crossed 100 mesh sieves, and is aseptic subpackaged by each consumption 0.6g～1.0g, and sealing promptly.

Claims

1. the preparation method of a compound Qingdaisan powder is characterized in that:

Form by the following raw materials according medicine: Fructus Cnidii 200kg, Rhizoma Coptidis 150kg, Radix Sophorae Flavescentis 200kg, Cortex Pseudolaricis 100kg, Folium Caryophylli 100kg, dry Alumen 10kg, CATECHU 8kg, Realgar 6kg, Fel Ursi 2kg;

Preparation as follows:

The first step: Fructus Cnidii and Folium Caryophylli adopt water to do the leaching solvent respectively, adopt infusion process, and decocting method or percolation after leachate filtered, are concentrated into relative density and are: the thick paste 1 of 1.20-1.25; Add 8-10 after the Radix Sophorae Flavescentis fragmentation and doubly measure 0.2% sulfuric acid solution, heating extraction twice, each about 1 hour, merging filtrate, transferring pH value with 10% sodium hydroxide solution is 7, leaves standstill 2 hours, filters, filtrate is concentrated into the thick paste 2 that relative density is 1.20-1.25; Add the 0.1% citric acid solution that 8-10 doubly measures after the Rhizoma Coptidis fragmentation, heating extraction twice, each about 1 hour, merging filtrate, using calcium carbonate or sodium hydroxide adjustment pH value is 7, leaves standstill 2 hours, filter, filtrate is concentrated into relative density and is: the thick paste 3 of 1.12-1.22; 75% alcoholic solution that adds 5 times of amounts after the Cortex Pseudolaricis shredding, put lixiviate 48 hours in the 40 degree hot water, incline and get supernatant, residue adds doubly 75% ethanol of 1-2 again, put lixiviate 48 hours in the 40 degree hot water, filter, filtrate and the merging of above-mentioned supernatant, reclaim ethanol to there not being the alcohol flavor with the way of distillation, being condensed into relative density is the thick paste 4 of 1.20-1.25;

Second step: after above-mentioned thick paste 1,2,3,4 mixing, adopt hypobaric drying method, thermal vapor stream seasoning or freeze-drying drying are pulverized, and cross 100 mesh sieves, become medicated powder A; Dry Alumen, CATECHU and Realgar mix the back pulverizes, and crosses 100 mesh sieves, becomes medicated powder B; Fel Ursi is ground into fine powder, crosses 100 mesh sieves, becomes medicated powder C;

The 3rd step: with medicated powder A, B, the mutual mix homogeneously of C, put in 80 ℃ of far infrared casees, dry sterilization 2 hours is crossed 100 mesh sieves promptly.