CN105496804A - Formula for hair treatment and head psoriasis treatment, reagent kit thereof and application - Google Patents
Formula for hair treatment and head psoriasis treatment, reagent kit thereof and application Download PDFInfo
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- CN105496804A CN105496804A CN201510992268.2A CN201510992268A CN105496804A CN 105496804 A CN105496804 A CN 105496804A CN 201510992268 A CN201510992268 A CN 201510992268A CN 105496804 A CN105496804 A CN 105496804A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/36—Carboxylic acids; Salts or anhydrides thereof
- A61K8/362—Polycarboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/194—Carboxylic acids, e.g. valproic acid having two or more carboxyl groups, e.g. succinic, maleic or phthalic acid
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/37—Esters of carboxylic acids
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/02—Preparations for cleaning the hair
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q5/00—Preparations for care of the hair
- A61Q5/12—Preparations containing hair conditioners
Abstract
The invention relates to a formula for hair treatment and head psoriasis treatment, a reagent kit thereof and application. The formula comprises a component capable of being cross-linked with amino in keratin fibers, the component can be mixed with a hair dye or a blenching agent which can be commercially obtained, and the formula is used for enhancing hair quality, preventing alopecia and treating symptoms of psoriasis on the head.
Description
Technical field
The present invention relates to a kind of formula for the treatment of hair and treatment head Corii Bovis seu Bubali moss and test kit thereof and application, comprising provides a kind of and can be cross-linked composition amino in keratin fiber, and by this composition with can the hair dye that obtains of business or bleach mix.
Background technology
Corii Bovis seu Bubali moss is a noninfectious struvite dermatosis.In the patient of 70%, this disease leaves obvious vestige in the region of scalp: a large amount of scalp injury, red infected zone and inflammation.Therefore, if a kind of hair treatment formulations can be developed, nutrition can be provided to alleviate again the symptom of head Corii Bovis seu Bubali moss for hair, will very large market be had.
Disclose in European patent application EP 234261 and can provide nutrition for hair and hair can be made to be easy to the treatment of hair reagent of combing.This reagent can be used on clean still moist hair with the form of rinse solution or Emulsion, and stops a few minutes to one hour on hair, and then hair is cleaned with clear water.
Above-mentioned hair nursing mode only to the hair of drying and the hair of porous effective.For rapidly by the hair of oiling, its effect is remarkable, because hair is more oily after using, thus causes hair style can not be permanent.Hair style depend on two sulphur bridge key for a long time, cystine linkage is unstable, under the condition of reduction, be reduced into sulfydryl.There are many trials at present, make sulfydryl be oxidized to two sulphur bridge key by adding oxidant.These methods are used to the stability improving hair-waving.Many patents and patent application describe how to re-establish cystine linkage, such as US9,095,518, US2015034119A1,201537270A1,201537271A1 and WO2015017768. be space but the technology described in these files still improves a lot.
Also have many trials in prior art, overcome defect in known hair care technology by adding aminoacid, the mixed weak acids solution of such as each seed amino acid and vitamin is as hair conditioner (US-PS4201235).But, prepare one kind of multiple such vitamin and amino acid mixture solution and extremely to bother and expensive.
" make up and cosmetic product " Vol98 (1983), S.59-68, in describe use keratin hydrolyzate and citric acid in one He in shampoo.But this shampoo only has very low hair care function, and hair can be caused extremely withered.Therefore, need once even repeatedly to use hair conditioner after hair washing.
Document W.Fassbender, perfume & cosmetics, 39 (1), S.11-16 (1958), disclose and the mixture containing 18 to 22 seed amino acids can be used in skin protection and treatment.This mixture can be obtained by the hydrolyzate of separating natural albumen and cleaning afterwards.Therefore, the component ratio reached required for cosmetics is difficult to.
In the prior art, the formula with the treatment of hair alleviating Corii Bovis seu Bubali moss symptom or reagent is not mentioned.
Summary of the invention
In view of above problem, the object of this invention is to provide a kind of formula for the treatment of of hair, this formula contains at least bifunctional active component, can treat and alleviate the symptom of Corii Bovis seu Bubali moss at head.This formula contains fumaric acid and the cautious alkali of bifunctional Bu Lunsi, reacts, thus improves the quality of hair from every side, and significantly improve the stability of curly hair with the amino in hair.Meanwhile, the difunctional fumaric acid contained in formula can be treated and be alleviated the Corii Bovis seu Bubali moss symptom of head.
Concrete technical scheme is as follows:
A formula for novel treatment of hair, for obtaining hair style steady in a long-term, and can alleviate head Corii Bovis seu Bubali moss symptom.This reagent has following component:
A) have the cautious alkali of at least bifunctional Bu Lunsi that a kind of molecular formula is X-R-Y, wherein X and Y is proton acceptor, and R is one containing 1 to 20 carbon atom, 0 to 5 oxygen atom, and the organic spacer of 0 to 5 nitrogen-atoms, the molecular weight of X-R-Y is less than 500g/mol, and
B) can treat Corii Bovis seu Bubali moss and the acid can reacted with the amino in hair, this acid is fumaric acid.
Further, the pH of component (a) is 7 to 12, and the pH of component (b) is 1.5 to 7.
The weight percentage of the dual-function compound in above-mentioned two kinds of compositions is 1 ~ 30%.
Composition is a) general at composition b) use before.Also can by composition b) be used in composition a) before.
Fumarate has been the known oral medicine being used for the treatment of Corii Bovis seu Bubali moss.Do not report at present and prove that fumaric acid itself can be used for treating Corii Bovis seu Bubali moss as application compress, because Corii Bovis seu Bubali moss is not regarded as a kind of dermatosis, but a kind of metabolic disease.
But surprisingly found now, fumaric acid is as application compress and be used in head hair region in the basic conditions and have significant curative effect to Corii Bovis seu Bubali moss.Importantly, and not merely use fumaric acid, because it has stimulation to skin, but use under alkaline environment, it can be impelled to form ester.
The present invention by first using containing the cautious alkali of Bu Lunsi on hair, and pH value is the formula of 7 to 12, then uses the formula containing fumaric acid of pH value between 1.5 to 7, obtain fumarate by fumarate derivative.
Wherein in step (a), proton acceptor X and Y of the cautious alkali of at least bifunctional Bu Lunsi independently selects in carboxylate, nitrate, hydrophosphate, phosphate, primary amine, secondary amine, sulfate and carbonate.
Preferably, step (a) is separately mixed in a carrier with the formula in step (b), and the carrier wherein in formula (a) is identical with the carrier in formula (b) or not identical.
Preferably, the formula in step (a) was mixed into the agent of dye method or bleach that can buy acquisition in use before hair.
Preferably, before carrying out step (a), hair is by the hair care ingredient process containing thioglycolic acid.
The present invention relates to a kind of formula for the treatment of hair and treatment head Corii Bovis seu Bubali moss: (a) by a formula for hair, this formula has the cautious alkali of at least bifunctional Bu Lunsi that a kind of molecular formula is X-R-Y, wherein X and Y is proton acceptor, R is one containing 1 to 20 carbon atom, 0 to 5 oxygen atom, and the organic spacer of 0 to 5 nitrogen-atoms, the molecular weight of X-R-Y is less than 500g/mol, b () a kind of can treat Corii Bovis seu Bubali moss and the acid can reacted with the amino in hair is selectively cleaned, and/or dry hair, it is characterized in that, the pH of formula (a) is 7 to 12, the pH of formula (b) is 1.5 to 7.
Detailed description of the invention
In this application, comprise all embodiments, be below defined as master, unless otherwise described.All percentage ratio is the percentage by weight of total composition.All proportions is part by weight." part ", such as mixture 1 part of X, 3 parts of Y are weight ratios." QS " or " QSP " means quantity is 100% or 100g, and +/-is standard deviation.All scopes are that can comprise and combinative.The quantity of significance bit does not have restriction effect to institute's exponential quantity, does not represent the accuracy of measurement yet.All numerals are all described by " approximately ".All measurements are all carried out under 25 DEG C and environmental condition." environmental condition " refers to 1 atmospheric pressure, 50% relative humidity." relative humidity " refers to the percentage ratio of atmospheric water content relative to identical temperature gentle pressure saturated humidity level.Relative humidity can be measured with drimeter." min " refers to minute, and " mol " refers to mole, and " nm " is nanometer." g " is gram." comprise " step and the composition that refer to contain other, comprise " by ... composition " and " primarily of ... composition ".Embodiment and described aspect thereof can comprise or composition, feature and other embodiments that clearly can not announce with those combined, unless clearly set forth not meeting property." at least one embodiment " refer to one or more embodiment, or all embodiments or most embodiment all has described feature.
" viscosity ", at 25 DEG C, uses HAAKE to rotate viscosity measuring instrument VT550, and use cooling/heating device and induction system to measure, according to DIN53019, shearing is 12.9s
-1.
Water-solublely can refer to can be formed in water when concentration is 0.1% at 25 DEG C and be judged as limpid solution according to naked eyes.
" substantially do not have " to refer to be less than 1% in composition or formula altogether, or be less than 0.8%, or be less than 0.5%, or be less than 0.3%, or be about 0%.
" keratin fiber " refers to the fiber be made up of keratin." hair " refers to mammiferous keratin fiber.In at least one embodiment, " hair " refers to the hair of people." hair shaft " or " wool fibre " refers to single hair line, can with " hair " one word use mutually.
" make up and can accept " and refer to described composition, formula can contact with human body keratin tissue and not have excessive toxicity.
" derivant " includes but are not limited to acyl, ester, carboxylic acid, acid, salt, alcohol etc.
" monomer " refers to single, unpolymerized, can form macromolecular chemical unit under certain condition by polyreaction.
The compound of " polymer " two or more monomer polymerization." polymer " comprises all materials synthesized by monomer chemistries and also comprises natural polymer.Homopolymer is called by a kind of polymer of monomer polymerization.The polymer be polymerized by two or more different monomers is called copolymer.The distribution of different monomers can be random, be separated by or block.Use in the present invention " polymer " refers to the polymer of any kind, comprises homopolymer and copolymer.
" test kit " refers to the packaging containing Multiple components.An example of test kit is, containing the first composition, and the second composition separately packed, and can operation instruction be contained.
Detail of the present invention is described below:
The invention describes and strengthen keratin fiber and alleviate and treat the formula of head Corii Bovis seu Bubali moss symptom.This formula by using reinforcing formulation or by this formula and the obtainable hair dye of business or bleach, reaching semipermanent strengthening effect on hair.The method contains two kinds of different formula, and wherein a kind of pH value of formula is greater than 7, and the pH value of another kind of formula is less than 7.First formula is alkalescence, and second formula is acid.After hair strengthening effect is at least maintained to once hair washing.In addition, inventor finds, this method increases hair style water-resistance and moisture resistance, adds the plasticity of hair after using shampoo.After mixing with business obtainable dye method agent or bleach, retroaction be there is no to hair dyeing and bleaching.
Above-mentioned effect comes from used step, the order of these steps, and the special composition comprising activating agent.Active component in acid formula is diffused in the hair shaft of keratin fiber, reacts, and the functional group in keratin structure be cross-linked with the amino in keratin polypeptide, by providing enough commissure for resisting the recovery strength of instinct in keratin.Described acid ingredient can not react with potential sulfydryl in hair, because reaction condition is acid.In theory, potential sulfydryl reaction needed deprotonation.Because the protonating agent in the present invention is the acid stronger than sulfydryl, such reaction can not occur.Active component in base formulation diffuses in the keratin fiber in hair shaft, reacts and be cross-linked these functional groups with the carboxylic acid group in keratin polypeptide.The stable reinforcement of keratin can be formed like this, such as, can carry out permanently effective reparation to hair damage.
The detail of different aspect of the present invention is described below.
crosslinking component:
Crosslinking component of the present invention is different mutually, with collaborative mode combined effect.The order used does not associate with its effect, but when it mixes with the agent of commercially available dye method or bleach, its order used is just relevant with effect.Commercially available hair dye and bleach contain makes pH be alkaline pH regulator composition.During hair oxidation dyeing, the change of pH value 0.5 can make the final color of hair change.When business can obtain the use of bleached hair formula, when pH value change is more than 0.5, its discoloration can be made to reduce.Therefore, when needs add additive in commercially available hair dye and bleach, significantly these additives can not change the pH value of hair dye and bleach.The pH value of commercially available hair dye and bleach is 8 to 12, so it is important to make it mix mutually with alkaline components of the present invention.When formula of the present invention mixes mutually with commercially available hair dye and bleach, mixing formula first uses, and then uses unmixing strong composition.The residence time of 1 to 45 minute is preferably had between each step.Optionally, hair is cleaned and drying between first step and second step.Optionally, send out into by force with alkalescence the waiting time that the time step by step has 1 to 45 minute in use acidity.
Acid strong composition (b) of sending out generally uses after alkalescence sends out composition (a) by force, and containing fumaric acid as cross-linking agent.Fumaric acid is the preferred of an acid strong composition, because it can connect adjacent amino.Fumaric acid is natural acquisition, more gets consumer reception relative to the bifunctional Brnsted acid of synthesis.This is not only because healthy reason, also has sustainability and environment reason, because the compound nature of natural acquisition and promptly decomposing, and does not need special processing mode.Further, they are relatively cheap.
Alkalescence is strong sends out the activating agent in composition and the carboxylic acid reaction in hair, and provides in hair protein and be further cross-linked.Containing keratic polypeptide in hair, these polypeptide contain carboxylic acid group [-COOH], hydroxyl [-OH], amino [-NH
2], and potential sulfydryl [-SH].Different active component and different functional group reactionses.Such as, at least bifunctional Brnsted acid reacts with amino, and at least bifunctional proton acceptor is in carboxyl reaction.
It is 1 to 30% that fumaric acid and at least bifunctional proton acceptor account for weight ratio that is acid or alkaline crosslinking component altogether, is preferably 2 to 25%, is more preferably 3 to 20%, be particularly preferably 4 to 15%, be preferably 5 to 10% the most.At least bifunctional proton acceptor is 1:1 to 3:1 with the mol ratio of at least bifunctional Brnsted acid, is preferably 1.5:1 to 2.5:1, is particularly preferably 2:1 to 2.5:1.
In at least one embodiment, a cosmetic acceptable carrier is contained separately in acid and alkaline crosslinking component.In at least one embodiment, it is that arbitrary active component that can make is allocated in crosslinking component that described cosmetic can accept carrier, can be used on hair.In at least one embodiment, described carrier is a water-solubility carrier, or a soluble alcohol carrier.In at least one embodiment, when described carrier is a soluble alcohol carrier, this carrier contains water and a kind of ethanol.In at least one embodiment, described ethanol is selected from ethanol, isopropyl alcohol, propanol, or its mixture.In at least one embodiment, when described carrier is water-solubility carrier, this carrier does not mainly also have ethanol substantially containing water.In at least one embodiment, described acidity and alkaline crosslinking component independently contain the cosmetic acceptable carrier of a safety and effective dose separately.In at least one embodiment, described acidity and alkaline crosslinking component separately independently containing relative in crosslinking component about 0.1% to 99%, or about 1% to 98%, or about 10% to 97%, or the water of about 30% to 95%.
Acid and alkaline crosslinking component can contain other compositions.In at least one embodiment, acid and alkaline crosslinking component contains antioxidant.Antioxidant has effect providing in long-term crosslinked stability.In at least one embodiment, described acidity and alkaline crosslinking component contain 0.001% to 5%, or the antioxidant of 0.5% to 1.0%.In at least one embodiment, described antioxidant is selected from ascorbic acid (vitamin C), the ascorbic acid fat of fatty acid, ascorbic acid derivates (such as, magnesium ascorbyl phosphate, sodium ascorbyl phosphate, ascorbyl sorbate), vitamin E, tocopherol sorbic acid ester, tocopherol acetate, other esters of tocopherol, butylhydroxy benzoic acid and its salt, peroxide, comprises hydrogen peroxide, peroxy-borate, thioglycolate salt, persulfate, 6-hydroxyl-2,5,7,8-tetramethyl benzodihydropyran-2-carboxylic acid (trade name Trolox
tM), gallic acid and alkane ester thereof, especially propyl gallate, uric acid and salt thereof and alkane ester, its salt of ferulic acid and alkane ester, sorbic acid and salt thereof, thioctic acid, amine (such as, N-diethyl hydroxylamine, aminoguanidine), containing sulfur-based compound (as glutathion), Dihydroxyfumaric acid and salt thereof, betanin, nordihydroguaiaretic acid, bioflavonoids, curcumin, lysine, 1-methionine, proline, superoxide dismutase, silymarin, tea extract, Pericarpium Vitis viniferae or Semen Vitis viniferae extract, melanin, rosemary extract, with and composition thereof.In at least one embodiment, described polyphenoils is a kind of ester of tocopherol sorbic acid ester or tocopherol.In at least one embodiment, described polyphenoils is sodium benzoate.In at least one embodiment, described polyphenoils is ferulic acid.The advantage of ferulic acid is to strengthen the oxidation stability in formula.In at least one embodiment, described acidity and alkaline crosslinking component contain the ferulic acid of a safety and effective dose.In at least one embodiment, described crosslinking component contains about 0.001% to 5%, or the ferulic acid of about 0.5% to 1.0%.
In at least one embodiment, acid and alkaline crosslinking component contains an intercalating agent.Intercalating agent refers to and can by the active substance of metal ion by it being removed from system with its formation complex, thus these metal ions can not be participated in or catalyzed chemical reaction.Comprise intercalating agent can prevent from causing transition to peel off and the ultraviolet radiation of skin damage and other can cause material in the environment of skin injury, thus reduce the content of the local iron ion that can cause oxidation and mottle.Intercalating agent can increase the long-time stability of crosslinking component.In at least one embodiment, described acidity and alkaline crosslinking component contain the intercalating agent of a safety and effective dose.In at least one embodiment, described acidity and alkaline crosslinking component contain an intercalating agent, described intercalating agent is selected from N-hydroxy-succinamide, EDTA, NTA, deferoxamine, hydroxamic acid and salt thereof, phytic acid, phytate, Portugal's (grape) saccharic acid and plays salt, siderophillin, lactoferrin, with and composition thereof.In at least one embodiment, described acidity and alkaline crosslinking component contain the intercalating agent of a safety and effective dose.Described acidity and alkaline crosslinking component contain about 0.001% to 10%, or about 0.01% to 5%, or about 0.1% to 5%, or the intercalating agent of about 0.5% to 1.0%.Operable intercalating agent is published in patent document U.S.Pat.No.5, and 487, in 884, be published on January 30th, 1996, author is Bissett etc., international patent application file, No.91/16035, author is Bushdeng, be published in October 31 nineteen ninety-five, and international patent application file, No.91/16034, author is Bushdeng, is published in October 31 nineteen ninety-five.In at least one embodiment, described intercalating agent is selected from N-hydroxy-succinamide, deferoxamine, hydroxamic acid and salt thereof, phytic acid, Portugal's (grape) saccharic acid and its derivant, and mixture.
In at least one embodiment, the form of described acidity and alkaline crosslinking component is suitable for hair.In at least one embodiment, described acidity and alkaline crosslinking component are an Emulsion, a solution, or dispersion liquid.In at least one embodiment, described crosslinking component contains a surfactant.This surfactant can manufacture Emulsion.In at least one embodiment, Emulsion can be a Wo-emulsion, or oil-water emulsions, or multicomponent Emulsion.The advantage of Emulsion is easy to use.Described acidity and alkaline crosslinking component can be flushing frees, also can be wash types.Described acidity and alkaline crosslinking component also can be the forms of hair conditioner.
Described acidity and alkaline crosslinking component can also contain at least one Cosmetic Ingredient, are selected to mould to send out polymer, hair care ingredient, and hair rinses composition, or its mixture.In at least one embodiment, described acidity and alkaline crosslinking component contain mould send out a polymer.In at least one embodiment, mould a polymer described in be selected from: nonionic is moulded and sent out a polymer, and anion plastic sends out polymer, and amphion is moulded and sent out a polymer, and cation is moulded and sent out a polymer, or its mixture.Spendable mould send out a polymer can at the CTFA International Cosmetic Ingredient dictionary handbook of 2008, " hairspray ", finds in the 12nd version.Suitable mould that to send out a polymer can be the polymer that european patent application the 08151246.9,12nd page of the 5th row delivered on February 11st, 2008 is announced in the 19th page of the first row.
In at least one embodiment, described acidity and alkaline crosslinking component contain percentage by weight and are approximately 0.01% to 10%, or about 0.1% to 8%, or about 0.1% to 5% mould and send out a polymer.
In at least one embodiment, described crosslinking component contain a nonionic mould send out a polymer.In at least one embodiment, moulding described in and sending out polymer is a natural or artificial-synthetic copolymer.In at least one embodiment, described nonionic mould send out a polymer be selected from by the polymer of following monomer polymerization: vinylpyrrolidone, caprolactam ethylene, vinyl acetate, vinyl alcohol, vinylacetate, (methyl) acrylamide and/or its derivant, (methyl) acrylic acid and salt thereof, and/or its derivant, propylene, glycol acid, .beta.-methylacrylic acid, or its mixture.Such as, the trade name of these polymer can be
or Luviset
In at least one embodiment, described crosslinking component contains an anion plastic and sends out polymer.In at least one embodiment, described anion plastic is sent out polymer and is selected from: acrylic acid/alkyl acrylate/N-alkyl acrylamide terpolymer, vinylacetate/crotonic acid-copolymers, C1-C5-alkyl acrylate/(methyl) acrylic copolymer, kayexalate, vinylacetate/butenoic acid/vinyl chain alkanoic acid ester copolymer, vinylacetate/butenoic acid/vinyl neodecanoate copolymer, aminomethylpropanol acrylic copolymer, vinylpyrrolidone/(methyl) acrylic copolymer, methyl vinyl ether/Malaysia mono alkyl ester copolymer, aminomethylpropanol salt/the methacrylate copolymer of allyl methacrylate, ethyl acrylate/methacrylic acid copolymer, vinylacetate/n-butyl maleate/isobornyl acrylate copolymer, octyl acrylamide/methacrylic acid copolymer, the polyester of diethylene glycol, cyclohexanedimethanol, M-phthalic acid, sulfoisophthalic acid, with and composition thereof.
In at least one embodiment, described acidity and alkaline crosslinking component contain an amphion mould send out a polymer.In at least one embodiment, described amphion is moulded a polymer and is selected from: N-alkyl acrylamide/fatty aminoalkyl methylmethacrylate/methacrylic acid copolymer, with there is the monomer of tertiary amine groups and there is the copolymer of monomer polymerization of acid group, fatty alcohol acrylate, alkylamine oxidation methyl acrylate, and the copolymer of at least one monomer in acrylic acid and methacrylic acid, polyquaternary ammonium salt-47, polyquaternary ammonium salt-43, the oligomer of crotonbetaine or crotonobetaine ester or polymer, and composition thereof.
In at least one embodiment, described acidity and alkaline crosslinking component contain a cation mould send out a polymer.In at least one embodiment, described cation is moulded and sent out polymer is a kind of homopolymer or a kind of copolymer, and wherein quaternary amine base is present in main polymer chain or the substituent group as one or more cation monomer.Can the copolymerization of anon-normal ion monomer containing ammonium monomer.Suitable cation can be the compound of unsaturated polymerizable, and this compound can contain at least one cation group, especially vinyl ammonium salt, such as, trialkyl methyl acryloxyalkyl ammonium, trialkyl acryloxyalkyl ammonium, dialkyl ammonium hexadiene ammonium, and the quaternary ammonium ethylene ammonium monomer containing the positive nitrilo of ring, such as, pyridine, imidazole salts, season ketopyrrolidine, as alkyl vinyl imidazolium salt, alkylvinylpyridines, or alkyl vinyl pyrrolidone salt.Alkyl in these monomers is preferably low alkyl, as C1 to C7 alkyl, and particularly preferably C1 to C3 alkyl.Suitable anon-normal ion monomer shell is selected from: Methacrylamide and derivant thereof, acrylate and derivant thereof, vinyl caprolactam, caprolactam, vinyl pyrrolidone, vinyl acetate, vinyl alcohol, propylene glycol, ethylene glycol.Such as, suitable cation is moulded and sent out polymer is the polymer having following trade name, Gafquat755N, Gafquat734, GafquatHS100, LuviquatHM550, MerquatPlus3300, GaffixVC713, AquaflexSF40.In at least one embodiment, described crosslinking component contain one from natural polymer derivative and cation that is that come mould and send out a polymer.In at least one embodiment, described natural polymer is selected from: the cation derivant of polysaccharide, such as cellulose, starch, and or Guar beans, chitosan, its salt, and/or its derivant, or its mixture.In at least one embodiment, described cation is moulded a polymer and is selected from: polyquaternary ammonium salt-4, Polyquaternium-10, polyquaternary ammonium salt-24, melon that hydroxypropyl ammonium chloride, with and composition thereof.
In at least one embodiment, described acidity and alkaline crosslinking component contain a hair care ingredient.Described acidity and alkaline crosslinking component contain any suitable, traditional hair care ingredient.Here hair care ingredient refers to any cosmetic acceptable, can improve hair appearance, such as make hair glossy, be easy to combing, touch and feel, have the composition of volume.Spendable hair care ingredient can at the CTFA International Cosmetic Ingredient dictionary handbook of 2008, and " hair care ingredient ", finds in the 12nd version.In at least one embodiment, described hair care ingredient is selected from: ionic surfactant, non-ionic surface active agent, silicon compound, organic oiliness hair care ingredient, with and composition thereof.Suitable hair care ingredient can be the polymer that european patent application the 08151246.9,19th page of the 3rd row delivered on February 11st, 2008 is announced in the 27th page of the 33rd row.
In at least one embodiment, described hair care ingredient is an ionic surfactant.In at least one embodiment, described ionic surfactant contains amino or quaternary ammonium group.In at least one embodiment, described acidity and alkaline crosslinking component contain about 0.05% to 3.5%, or about 0.1% to 3.0%, or the ionic surfactant of about 0.5% to 2.5%.In at least one embodiment, the molecular formula of described ionic surfactant is Formulae II:
Wherein, R
71, R
72, R
73in at least one is selected from: the fat-based containing 1 to 22 carbon atom, the aromatic radical containing maximum 22 carbon atoms, alkoxyl, polyoxyalkylene, alkylamide, hydroxyalkyl, aryl or alkylaryl; X is selected from: halogen, acetate, citrate, lactate, oxyacetate, phosphate, nitrate, sulfate, sulfonate, alkyl sulfate, with and composition thereof.In at least one embodiment, the molecular formula of described ionic surfactant as shown in Formulae II, wherein, R
71, R
72, R
73and R
74in at least one is fat-based containing 16 to 24 carbon atoms, remaining R
71, R
72, R
73and R
74the respective group being independently selected from fat-based containing 1 to 4 carbon atom, X is sulphuric acid or hydrochloric acid.In at least one embodiment, described ionic surfactant is selected from: INCROQUAT TMC-80 ECONOL TM22, Methylsulfate, ethyl-sulfate, octadecyl trimethyl ammonium chloride, with and composition thereof.It is generally acknowledged, relative to the ionic surfactant containing shorter alkyl chain, longer alkyl chain can improve the smoothness of dry or moist hair and touch sense, also can reduce scalp irritation.In at least one embodiment, described ionic surfactant is the long alkyl quaternary ammonium salts of a pair of, be selected from: dialkyl group (14 to 18 carbon atoms) alkyl dimethyl ammonium chloride, alkyl dimethyl ammonium chloride, dihydro tallow alkyl alkyl dimethyl ammonium chloride, VARISOFT TA100, Varisoft 432PPG, with and composition thereof.In at least one embodiment, described ionic surfactant is the amino amine of uncle containing 12 to 22 carbon atom alkyls.In at least one embodiment, described ionic surfactant is selected from: cetyltrimethyl ammonium salt, behenyl trimethyl ammonium salt, ditallow dimethyl ammonium, stearamidopropyl dimethylamine, (2) ester quat, quaternary ammonium salt 8,14,15,18,22,24,26,27,30,33,37,53,60,61,72,78,80,81,82,83,84, and/or 91, or its mixture.
In at least one embodiment, described hair care ingredient is a non-ionic surface active agent.The HLB of suitable non-ionic surface active agent is less than 8.Suitable non-ionic surface active agent is selected from: glyceryl ester, sugar ester, alkyl polyglucoside ether, the many glucosides of oleyl, or the many glucosides of plant sterol, polyoxyethylene 20 sorbitan monostearate, or its mixture.
In at least one embodiment, described hair care ingredient is a silicon resin compound.At least wanting in an embodiment, described silicon compound is one volatilizable or not volatilizable, and/or solvable or insoluble silicon compound.Suitable silicon resin compound can be the product having following trade name: SF1075 benzyl oil (Utilities Electric Co.), DC244, DC245, DC345, Dow5/7113, DC556 cosmetics-stage oil, DC1248 (Dow Corning Corporation).In at least one embodiment, the hair care ingredient that described acidity and alkaline crosslinking component contain is the product of following reactant: (a) amino silane, (b) polysiloxanes, and optional (c) polyethers.In at least one embodiment, the hair care ingredient that described acidity and alkaline crosslinking component contain is the product of following reactant: (a) amino silane, (b) polysiloxanes, and (c) polyethers.In at least one embodiment, described acidity and alkaline crosslinking component contain a hair care ingredient, and this hair care ingredient is selected from: epoxy amino silane copolymer, and Polysiloxane-polyurea block copolymer, with and composition thereof.In at least one embodiment, the hair care ingredient that described acidity and alkaline crosslinking component contain is the product of following reactant: (a) amino silane, (b) polysiloxanes, (c) polyethers, and optional (d) amine.In at least one embodiment, described polysiloxanes is an epoxy polysiloxane.In at least one embodiment, described polysiloxanes contains at least two oxirane or oxetanes.In at least one embodiment, state polysiloxanes and contain 10 to 450 silicon atoms, or 40 to 400 silicon atoms, or 75 to 350 silicon atoms, or 150 to 250 silicon atoms.In at least one embodiment, the structural formula of described polyethers is CH
2(O) CHCH
2o (CH
2(CH
3) CH
2o)
ncH
2cH (O) CH
2(on average), wherein n is the integer in 1 to 10.In at least one embodiment, described amine contains 1 to 10 carbon atom, or 2 to 5 carbon atoms.In at least one embodiment, described amine is one at least by alkylamine that alkyl replaces.In at least one embodiment, described amine is selected from: methylamine, ethamine, propylamine, ethanolamine, isopropanolamine, butylamine, isobutyl amine, hexylamine, dodecyl amine, oleamide, the aminopropyl trimethoxylsilane of aniline, aminopropyl triethyl silicane, amino-morpholine, stearamidopropyldiethylamine benzylamine, naphthylamines Aminoethyl carbazole, amino heptachlor hexane, 2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-15 fluoro-1-octylame, its mixture of ethyl.In at least one embodiment, described amine is selected from: methyl ethyl-amine, tuaminoheptane, methyl lauryl amine, diethanolamine, dibenzyl amine, diethylamine dicyclohexylamine, piperidines, pyrrolidine phthalimide, its mixture of ethyl.In at least one embodiment, described hair care ingredient is an epoxy amino silane copolymer.In at least one embodiment, the hair care ingredient that described acidity and alkaline crosslinking component contain is the product of following reactant: (a) amino silane, (b) polysiloxanes, wherein said polysiloxanes contains about 10 to 450 silicon atoms, or about 40 to 400 silicon atoms, and (c) polyethers, and (d) amine, the wherein alkylamine that replaced by least one alkyl of amine.
In at least one embodiment, described acidity and alkaline hair care ingredient are selected from: epoxy amino silane copolymer, Polysiloxane-polyurea block copolymer, with and composition thereof.In at least one embodiment, described conditioner is a polydimethylsiloxanederivative derivative, and this derivant contains aminoalkyl and amido.Described polydimethylsiloxanederivative derivative can be, such as, containing methoxyl group or hydroxyl, or its mixture.
In at least one embodiment, described conditioner is an organic oiliness hair care ingredient.In at least one embodiment, described organic oiliness hair care ingredient is nonvolatile, water miscible, or oiliness.Organic oiliness hair care ingredient can be selected from hydrocarbon oil and oily ester.In at least one embodiment, described conditioner is an oils and fats alcohol.In at least one embodiment, described hair care ingredient is one non-volatile, the oils and fats alcohol of low melting point.In at least one embodiment, described conditioner is an oiliness alcohol, and this oiliness alcohol is selected from: lauryl alcohol, octadecanol, hexadecanol, tetradecanol, with and composition thereof.
Described acidity and alkaline crosslinking component can also contain at least one direct dyes.In at least one embodiment, described direct dyes contains about 0.01% to 15%, or about 0.1% to 10%, or the hair direct dyes of about 0.5% to 8%.
Described acidity and alkaline crosslinking component can also contain at least one viscosity adjustment composition.In at least one embodiment, described crosslinking component contains about 0.01% to 20%, or about 0.05% to 10%, or the viscosity adjustment composition of about 0.1% to 5%.
Described acidity and alkaline crosslinking component can also contain at least one emulsifying agent and/or surfactant.In at least one embodiment, described emulsifying agent and/or surfactant are selected from non-ionic surface active agent, anionic surfactant, zwitterionic surfactant, or its mixture.In at least one embodiment, described acidity and alkaline crosslinking component contain about 0.01% to 20%, or 0.05% to 10%, or the emulsifying agent of 0.1% to 5% and/or surfactant.
Described acidity and alkaline crosslinking component can also contain at least one dyestuff.In at least one embodiment, described dyestuff is selected from natural dye, synthetic dyestuff, or its mixture.Described dyestuff can make organic dyestuff, inorganic dyestuff, or its mixture.Described dyestuff can be selected from colored dyes, pearl oyster dyestuff, or its mixture.Described acidity and alkaline crosslinking component can also containing about 0.01% to 10%, or the dyestuff of 1% to 2%, and this percentage ratio is the percentage by weight under non-dissolved state in described acidity and alkaline crosslinking component.Dyestuff in described acidity and alkaline crosslinking component can be inorganic, nitroso, azo, two diazonium, carotenoid, tritan., triarylmethane, xanthene, quinoline, oxazine dye, azine, anthraquinone, indigo, quinoline a word used for translation (two) ketone, phthalocyanine dye, vegetal, natural colour, water miscible, comprising those has C.I. name.
In at least one embodiment, described acidity and alkaline crosslinking component contain at least one special composition.In at least one embodiment, described special composition is selected from: silicon dioxide, silicate, aluminate, alum clay, Muscovitum, insoluble salt, especially insoluble inorganic metal salt, metal-oxide, mineral, insolubility polymer beads, or its mixture.In at least one embodiment, described acidity and alkaline crosslinking component contain about 0.01% to 10%, or the special composition of about 0.05% to 5%.In at least one embodiment, described acidity and alkaline crosslinking component do not inject the special composition of earth and so on substantially.
In at least one embodiment, described acidity and alkaline crosslinking component contain at least one antiseptic.Described acidity and alkaline crosslinking component contain percentage by weight about 0.01% to 5%, or the antiseptic of about 0.05% to 1%.
Described acidity and alkaline crosslinking component can contain other optional members various.These optional members can be selected from: antioxidant, chelating agen, solvent, spice, filler, screening agent, eliminating smell agent, stain, fat carrier, surfactant, adhesion agent, viscosity modifier, ultraviolet filtering agent, free radical resisting material, polyvinyl alcohol, pH adjusting agent, salt, stain, polymer plasticization agent, direct dyes, or its mixture.Described acidity and alkaline crosslinking component can containing the antibacterial of about 0% or 0.1% to 5%.In at least one embodiment, described acidity and alkaline crosslinking component contain an organic acid, and described organic acid is selected from: glycine, L-Methionine, L-arginine, biotin, flesh (ammonia) acid, with and composition thereof.In at least one embodiment, described acidity and alkaline crosslinking component contain pantothenylol.In at least one embodiment, described acidity and alkaline crosslinking component contain a wax compound.In at least one embodiment, described acidity and alkaline crosslinking component contain Cera Flava.
In at least one embodiment, the viscosity of described acidity and alkaline crosslinking component, weighing at 25 DEG C, is about 0.1mPa.s to 1000000mPa.s, or 1mPa.s to 80000mPa.s, or 5mPa.s to 3500mPas.Viscosity HAAKE rotary viscosity measuring instrument VT550 weighs.This measuring instrument contains cooling/heating container, and sensing system, and according to DIN53019 (MV-DIN, SV-DIN), shearing is 12.9s
-1.
In at least one embodiment, described acidity and alkaline crosslinking component contain a buffer agent.In at least one embodiment, described buffer agent is phosphate buffer.In at least one embodiment, described buffer agent is borate buffer or carbonate buffer agent.In at least one embodiment, described buffer agent is selected from: glycine/sodium hydroxide, sodium carbonate/bicarbonate, sodium tetraborate/sodium hydroxide, sodium bicarbonate/sodium hydroxide, ammonium chloride/ammonia.Described buffer can control ph, thus increases the stability of crosslinking component.In at least one embodiment, described acidity and alkaline crosslinking component contain an acid-base modifier.Described acidity and alkaline crosslinking component can contain with protonating agent.Described protonating agent can be simple substance or many Bronsted acid, water solublity or not water soluble acid, and/or organic or inorganic acid.In at least one embodiment, described protonating agent is selected from formic acid, acetic acid, sulphuric acid, hydrochloric acid, citric acid, with and composition thereof.
The present invention relates to a treatment of hair in addition and can treat the test-run a machine box of head Corii Bovis seu Bubali moss, containing composition (a) and composition (b), wherein composition (a) is the cautious alkali of at least bifunctional Bu Lunsi of X-R-Y containing a kind of molecular formula, wherein X and Y is proton acceptor, R is one containing 1 to 20 carbon atom, 0 to 5 oxygen atom, and the organic spacer of 0 to 5 nitrogen-atoms, the molecular weight of X-R-Y is less than 500g/mol, composition (b) is fumaric acid, fumaric acid can react with the amino in hair and can treat the Corii Bovis seu Bubali moss of head, wherein the pH of formula (a) is 7 to 12, the pH of formula (b) is 1.5 to 7.
The preferred treatment of hair of the present invention containing composition (a), the test kit of (b) and (c), wherein composition (a) is the cautious alkali of at least bifunctional Bu Lunsi of X-R-Y containing a kind of molecular formula, wherein X and Y is proton acceptor, R is one containing 1 to 20 carbon atom, 0 to 5 oxygen atom, and the organic spacer of 0 to 5 nitrogen-atoms, the molecular weight of X-R-Y is less than 500g/mol, composition (b) is fumaric acid, fumaric acid can react with the amino in hair and can treat the Corii Bovis seu Bubali moss of head, wherein the pH of formula (a) is 7 to 12, the pH of formula (b) is 1.5 to 7, composition (c) is hair conditioner.
Following examples further describe the example application in the scope of the invention.These embodiments are only used for explaining the present invention, do not limit the present invention, to a lot of amendments of these examples not away from protection scope of the present invention.
Embodiment 1
The scalp showing the patient of Corii Bovis seu Bubali moss symptom immerses the aqueous solution of 5% hexamethylene diamine (pH9.5) (composition 1), dry afterwards.
On scalp, use 10ml to contain 5% fumaric acid hair oil (composition 2) 10 minutes afterwards, and slowly dry.Such process repeats twice every day, continues 20 days.
Scalp is no longer scratched where it itches afterwards, and other symptoms of Corii Bovis seu Bubali moss also disappear.
Process is last, and composition (1) and (2) are employed successfully in and form curly hair.
Embodiment 2
The scalp showing the patient of Corii Bovis seu Bubali moss symptom cleans with the shampoo (composition 1) containing 5% hexamethylene diamine (pH9.5).Use containing 5% fumaric acid aqueous solution (composition 2) on scalp afterwards, and slowly dry.Such process repeats once every day, continues 10 days.
Scalp is no longer scratched where it itches afterwards, and other symptoms of Corii Bovis seu Bubali moss also disappear.
Process is last, and composition (1) and (2) are employed successfully in and form curly hair.
Claims (12)
1., for the treatment of hair and the formula for the treatment of head Corii Bovis seu Bubali moss, it is characterized in that, described formula is containing, for example lower component:
A () molecular formula is the cautious alkali of at least bifunctional Bu Lunsi of X-R-Y; Wherein, X and Y is proton acceptor, and R is an organic spacer containing 1 to 20 carbon atom, 0 to 5 oxygen atom and 0 to 5 nitrogen-atoms, and the molecular weight of X-R-Y is less than 500g/mol, and
B () can treat Corii Bovis seu Bubali moss and the acid of reacting with the amino in hair, described acid is fumaric acid;
Further, the pH value of component (a) is 7 to 12, and the pH value of component (b) is 1.5 to 7.
2. formula according to claim 1, is characterized in that, the concentration expressed in percentage by weight of the cautious alkali of described at least bifunctional Bu Lunsi in component (a) is 1 to 30%.
3. formula according to claim 1, is characterized in that, the concentration expressed in percentage by weight of described fumaric acid in component (b) is 1 to 30%.
4., according to the arbitrary described formula of claims 1 to 3, it is characterized in that, proton acceptor X and Y of the cautious alkali of described at least bifunctional Bu Lunsi independently selects in carboxylate, nitrate, hydrophosphate, phosphate, primary amine, secondary amine, sulfate and carbonate.
5. according to the arbitrary described formula of claims 1 to 3, it is characterized in that, material in described component (a) and component (b) is separately mixed in a carrier, wherein the carrier in component (a) and the carrier in component (b) identical or different.
6., according to the arbitrary described formula of claims 1 to 3, it is characterized in that, described component (a) was mixed into hair dye or bleach in use before hair.
7., according to the arbitrary described formula of claims 1 to 3, it is characterized in that, before use component (a), hair is by the hair care ingredient process containing thioglycolic acid.
8. the test kit for the treatment of of hair and treatment head Corii Bovis seu Bubali moss, it is characterized in that, described test kit contains composition (a) and composition (b);
Wherein, the at least bifunctional Bu Lunsi cautious alkali of composition (a) for containing molecular formula being X-R-Y, wherein X and Y is proton acceptor, and R is an organic spacer containing 1 to 20 carbon atom, 0 to 5 oxygen atom and 0 to 5 nitrogen-atoms, and the molecular weight of X-R-Y is less than 500g/mol;
Composition (b) is fumaric acid, and the amino in fumaric acid and hair reacts and treats the Corii Bovis seu Bubali moss of head;
The pH value of composition (a) is 7 to 12, and the pH value of composition (b) is 1.5 to 7.
9. test kit according to claim 8, is characterized in that, also containing composition (c), described composition (c) is hair conditioner.
10. fumaric acid and/or fumarate are as the application of hair nursing reagent, it is characterized in that, for strengthening hair quality, pre-Anti-hair loss and the treatment Corii Bovis seu Bubali moss symptom at head.
11. application according to claim 10, is characterized in that, the formula of use one containing the cautious alkali of at least bifunctional Bu Lunsi on hair.
12. according to the application of claim 10 or 11, and it is characterized in that, described fumarate is dimethyl fumarate ester.
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| CN105902404A (en) * | 2016-06-14 | 2016-08-31 | 知识产权全资有限公司 | Hair strengthening ingredient and method |
| CN105902403A (en) * | 2016-05-19 | 2016-08-31 | 知识产权全资有限公司 | Hair strengthening ingredient and hair-strengthening method |
| CN106265109A (en) * | 2016-08-22 | 2017-01-04 | 知识产权全资有限公司 | Strong composition and the strong method sent out and make hair have splendid feel |
| WO2018033821A1 (en) * | 2016-08-15 | 2018-02-22 | Saffron Secret Llc | Hair straightening combined with color correction using aerosol foam delivery |
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| CN105902403A (en) * | 2016-05-19 | 2016-08-31 | 知识产权全资有限公司 | Hair strengthening ingredient and hair-strengthening method |
| WO2017197931A1 (en) * | 2016-05-19 | 2017-11-23 | 知识产权全资产有限公司 | Hair strengthening ingredient and method for strengthening hair |
| CN111494227A (en) * | 2016-05-19 | 2020-08-07 | 知识产权全资有限公司 | Hair strengthening composition and method for strengthening hair |
| US11559475B2 (en) | 2016-05-19 | 2023-01-24 | Liw Patent Company Limited By Guarantee | Hair strengthening ingredient and method for strengthening hair |
| AU2017266787B2 (en) * | 2016-05-19 | 2023-10-19 | Liw Patent Company Limited By Guarantee | Hair strengthening ingredient and method for strengthening hair |
| CN105902404A (en) * | 2016-06-14 | 2016-08-31 | 知识产权全资有限公司 | Hair strengthening ingredient and method |
| WO2017215276A1 (en) * | 2016-06-14 | 2017-12-21 | 知识产权全资产有限公司 | Hair strengthening ingredient and hair-strengthening method |
| WO2018033821A1 (en) * | 2016-08-15 | 2018-02-22 | Saffron Secret Llc | Hair straightening combined with color correction using aerosol foam delivery |
| CN106265109A (en) * | 2016-08-22 | 2017-01-04 | 知识产权全资有限公司 | Strong composition and the strong method sent out and make hair have splendid feel |
| WO2018036105A1 (en) * | 2016-08-22 | 2018-03-01 | 知识产权全资产有限公司 | Method for strengthening and repairing hair, and kit therefor |
| EP3501489A4 (en) * | 2016-08-22 | 2020-08-12 | LIW Patent Company limited by guarantee | Method for strengthening and repairing hair, and kit therefor |
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Application publication date: 20160420 |