CN1076624A - Benefit Tianjin antihypelipidemic preparation and preparation method thereof - Google Patents
Benefit Tianjin antihypelipidemic preparation and preparation method thereof Download PDFInfo
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Abstract
A kind of beneficial Tianjin antihypelipidemic preparation for the treatment of diabetes and preparation method thereof.Said preparation contains Radix et Caulis Opuntiae Dillenii, Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, Radix Glycyrrhizae.Its preparation process is after the bright product of succulent stem of cactus are squeezed out juice and the fried liquid of all the other four kinds of prepared slices of Chinese crude drugs mixes, evaporation and concentration becomes thick paste, or produce fried liquid in the extraction pot with putting with succulent stem of cactus dry product and all the other four kinds of medicine decoction pieces, evaporation and concentration becomes thick paste, again above-mentioned thick paste is carried out precipitate with ethanol, filtration, recovery ethanol, continuing evaporation and concentration Radix et Caulis Opuntiae Dillenii content to the medicinal liquid is 50-200% (g/ml), and potus or other dosage form are promptly made in cold preservation, filtration, packing, sealing, sterilization.
Description
The present invention relates to a kind of Chinese medicine preparation, particularly a kind of beneficial Tianjin antihypelipidemic preparation that is applicable to the treatment diabetes and preparation method thereof.
At present, diabetes (diabetes) have become common chronic disease.The sickness rate of China's diabetes has the trend of increasing in recent years.The pathological changes of its pathological change ordinary wave and each system of meeting body, the chronic pathological changes as cardiovascular, kidney, nervous system and optical fundus seriously is detrimental to health.Classify the 3rd (except that cardiovascular disease and tumor) as at the mortality rate of American-European diabetes.Research to diabetes has been subjected to generally paying attention to.Existing Therapeutic Method generally adopts oral antidiabetic drug to reach hypoglycemic purpose.Common Western medicine has sulphanylureas (as glyburide) and biguanides (as insoral) etc., though hypoglycemic effect is better in the recent period for this class medicine, the treatment diabetes is had certain effect, and taking for a long time has certain side effect to human body.(Phenformin) belongs to chemosynthesis medicine as insoral, is that Ministry of Public Health new drug reviewing season person understands specified positive control drug.Its blood sugar reducing function mainly is used for realizing to the absorption of glucose, the release that reduces glyconeogenesis, glucagon suppression or inhibition insulin antibody thing by the inhibition intestinal.Its side effect mainly shows all has certain detrimental effect to hemogram, liver function, kidney merit, can cause patient's diabetic cardiovascular and cerebrovascular complication, occurs hypoglycemic reaction easily, and gastrointestinal is had zest, produces anorexia, feels sick, vomiting even diarrhoea etc.Therefore cause certain mental pressure to the patient.Although the now existing method that adopts treatment by Chinese herbs because of dosage is bigger, decocts, the normal phase takes equal inconvenience, onset is slow, applies so influence it.
Radix et Caulis Opuntiae Dillenii [Opuntia dillenii(ker-Gawl) Haw] and Yunnan Radix et Caulis Opuntiae Dillenii (Opuntia monocantha Haw) spread all over each province, China south, and the wild artificial culture that also has is arranged, and especially wild resource is extremely abundant, is not utilized as yet so far.
The purpose of this invention is to provide a kind of beneficial Tianjin antihypelipidemic preparation for the treatment of diabetes and preparation method thereof, the said preparation hypoglycemic activity is remarkable, effect stability; Taking dose is little, has no side effect, and is suitable for diabetics and takes for a long time.Its preparation method is easy, and sufficient raw can be made into various dosage forms.
The object of the present invention is achieved like this: the weight ratio of each component is succulent stem of cactus dry product 10-40 part, Radix Ginseng 1.5-3 part, Rhizoma Atractylodis Macrocephalae 1.5-3 part, Poria 1.5-3 part, Radix Glycyrrhizae 0.5-1.5 part in the said preparation.
The bright product of also available succulent stem of cactus replace dry product, and its consumption is a dry product: bright product=1: 5.
Formulation preparation method of the present invention is as follows:
Take by weighing raw materials usedly according to quantity, succulent stem of cactus dry product 10-40 part, Radix Ginseng 1.5-3 part, Rhizoma Atractylodis Macrocephalae 1.5-3 part, Poria 1.5-3 part, Radix Glycyrrhizae 0.5-1.5 part earlier are cut into 0.5-5cm with the succulent stem of cactus dry product
2Fritter, with Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, the decoction pieces of Radix Glycyrrhizae is with placing extraction pot, the 10-20 times of water that adds the raw material gross weight, soaked 6-12 hour down at 10-30 ℃, heat fried three times, each 1-3 hour, merge fried liquid, put in the vaporizer, relative density is that 1.10-1.25 ends when being no more than 100 ℃ of following evaporation and concentration and becoming 20 ℃, add thick paste total amount 1-3 medicinal alcohol doubly and carry out precipitate with ethanol, filter the filtering residue washing with alcohol of 40-80%, merging filtrate and washing liquid, reclaim ethanol, in that to be no more than 100 ℃ of following evaporation and concentration each component total content to the medicinal liquid be 50-200%(g/ml) packing, sealing in 100-115 ℃ of sterilization in 15-30 minute, is made medicinal liquid.
Also can take by weighing the bright product 50-200 of succulent stem of cactus part according to quantity, Radix Ginseng 1.5-3 part, Rhizoma Atractylodis Macrocephalae 1.5-3 part, Poria 1.5-3 part, Radix Glycyrrhizae 0.5-1.5 part become the long piece of 1-5cm with the bright product crosscut of succulent stem of cactus earlier, and it is standby to squeeze its bright juice with squeezer; Again with Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, the decoction pieces of Radix Glycyrrhizae is with placing extraction pot, add four kinds of water that decoction pieces gross weight 8-15 doubly measures, soaked 6-12 hour down at 10-30 ℃, heat fried three times, each 1-3 hour, merge fried liquid, above-mentioned bright juice is mixed with fried liquid, mix thoroughly, put in the vaporizer, becoming the thick paste shape being no more than 100 ℃ of following evaporation and concentration, is that 1.10-1.25 ends to 20 ℃ of relative densities, adds thick paste total amount 1-3 medicinal alcohol doubly and carries out precipitate with ethanol, filter, the filtering residue washing with alcohol of 40-80%, merging filtrate and washing liquid reclaim ethanol, in that to be no more than 100 ℃ of following evaporation and concentration each component total content to the medicinal liquid be 50-200%(g/ml) packing, sealing, in 100-115 ℃ of sterilization in 15-30 minute, make medicinal liquid.
On the basis of above-mentioned two kinds of methods, the medicinal liquid made is ended at the thick paste that to be no more than 100 ℃ of relative densities when continuing evaporation and concentration down and becoming 20 ℃ be 1.20-1.30, add the medical starch of thick paste total amount 1/3-1/5, mixing, make granule, the graininess electuary is made in dry, pack.Maybe the medicinal liquid made is ended at the thick paste that to be no more than 100 ℃ of relative densities when continuing evaporation and concentration down and becoming 20 ℃ be 1.20-1.30, add microcrystalline Cellulose or the Powderd cellulose of thick paste total amount 1/3-1/5, mixing is made granule, dry, be sub-packed in the capsule shells, make capsule.Maybe the medicinal liquid made is ended for the 1.20-1.30 thick paste being no more than 100 ℃ of relative densities when continuing evaporation and concentration down and becoming 20 ℃, the cellulose excipient microcrystalline Cellulose or the Powderd cellulose that add thick paste total amount 1/3-1/5, the hyprolose or the calcium carboxymethylcellulose that add thick paste and cellulose excipient total amount 1/50-1/20 again, mixing, granulate, hyprolose dry, its gross weight of adding 1-30% in dried granule or the magnesium stearate mixing of calcium carboxymethylcellulose and 0.5-2%, be pressed into tablet, pack into gastric soluble tablet with acrylic resin.
Because it is primary raw material that the present invention adopts the very abundant Radix et Caulis Opuntiae Dillenii of resource, is equipped with the medicinal herbs most in use such as Radix Ginseng of replenishing QI to invigorate the spleen again, makes compound preparation, so preparation method is easy, better stability of preparation.Diabetes spp is in traditional Chinese medical science diabetes category, and YIN fluid deficiency, production of dryness-heat in the interior are the pathogenetic basic pathologies of glycosuria.The Radix et Caulis Opuntiae Dillenii that preparation of the present invention adopts has nature and flavor bitter cold, GUIXIN, lung, stomach warp, moisturizes and quenches the thirst, heat-clearing and toxic substances removing, the function of promoting flow of QI and blood; The flat strongly invigorating primordial QI of the sweet little hardship of the Radix Ginseng of adapted, supplementing QI for promoting the production of body fluid; The bitter temperature of the Rhizoma Atractylodis Macrocephalae, the spleen invigorating QI invigorating; The sweet light eliminating dampness by diuresis of Poria, the sweet gentle middle benefit soil of Radix Glycyrrhizae.Above-mentioned all medicines share, the moon of lung spleen can be mended, the scorching of lung stomach gets clearly, effect with supplementing QI for promoting the production of body fluid, clearing heat and moistening dryness, promoting blood circulation and detoxication, substantially be consistent with the rule of treatment of TCM treatment of diabetes utilization " supplementing QI and nourishing YIN, clearing away heat and promoting production of body fluid ", and diabetes are easily merged Blood stasis and the infected all has prevention and therapeutical effect.Clinical observation and animal test results show, the preparation that adopts preparation method of the present invention to make, and taking dose is little, has no side effect, and blood sugar decreasing effect is remarkable, therefore, is suitable for diabetics and takes for a long time.
Benefit Tianjin oral liquid for decreasing blood sugar clinical observation 328 examples, 2-3 month course of treatment, total effective rate is 86.5%, obvious effective rate 31.4%.Compare curative effect with insoral matched group (116 example) and do not have significant difference.See Table 1
Table 1 treatment group and matched group are always treated number
| Total routine number | Produce effects | Effectively | Invalid | Increase the weight of | Total effective rate | |
| Treatment group matched group | 328 116 | 103 36 | 181 63 | 44 17 | 0 0 | 86.5% 85.3% |
| The P value | ＞0.05 | |||||
Oral liquid for decreasing blood sugar has the following advantages through clinical observation benefit Tianjin:
1, has significant hypoglycemic activity, wherein reduce every indexs such as fasting glucose, glucose in urine, post-prandial glycemia and glycolated hemoglobin and all be better than insoral.
2, the effect (P＜0.01) that has significant cholesterol reducing, triglyceride.Aspect protection diabetes patient blood vessel wall, reduction diabetic cardiovascular and cerebrovascular complication, show the outstanding advantage of beneficial Tianjin oral liquid for decreasing blood sugar.This is that insoral is incomparable.
3, have the immunologic function of raising, the effect of enhancing body anti-infective.Make immunoglobulin value (IgG) after receiving treatment, be significantly increased (P＜0.01).This be current chemosynthesis antidiabetic drug (comprising insoral) can't be obtained.
4, taking this preparation 2-3 month, hemogram, liver function, kidney merit, electrocardio etc. are not all had obviously influence, beneficial Tianjin oral liquid for decreasing blood sugar safety non-toxic is described, is the ideal Chinese patent medicines of treatment diabetes.
Drug effect: beneficial Tianjin antihypelipidemic preparation to alloxan induced hyperglycemia mice and continuous seven days of rats gavaged 30g/kg/ day, all presents remarkable hypoglycemic activity respectively, and its effectiveness is better than insoral (chemical synthetic drug).Anti-sugar experimental results show that the effect of beneficial Tianjin antihypelipidemic preparation is similar to insoral.Insoral (Phenformin) is to belong to chemosynthesis medicine (being that Ministry of Public Health new drug reviewing season person understands specified positive control drug), its blood sugar reducing function mainly be by suppress intestinal to the absorption of glucose, reduce glyconeogenesis, the release of glucagon suppression or suppress the insulin antagonist be used for realizing.Its side effect has anorexia, nausea,vomiting,diarrhea or hypoglycemic reaction etc. occurs.Benefit Tianjin antihypelipidemic preparation does not then have above-mentioned side effect, more hypoglycemic reaction can not occur, and this is the advantage place of this compound preparation just.
Toxicity: after beneficial Tianjin antihypelipidemic preparation is given mouse gavaging 384g/kg/ day, no abnormal finding, it is dead to observe seven days none examples, is 640 times of the consumption of being grown up; Intraperitoneal administration mice median lethal dose(LD 50) is the average fiducial limit of 46.06 ± 3.35g/kg(95%).
Give continuous 6 months of rat oral beneficial Tianjin every day antihypelipidemic preparation (30,15,7.5g/kg), hemogram, liver function and kidney merit are not had obvious influence; The main organs pathological examination results, in, low dose of toxic action is not obvious; Heavy dose of granular degeneration that can make renal tubular epithelial, but can recover after the drug withdrawal.In sum, this compound preparation toxicity is very little, takes safe and reliable for a long time.
The invention will be further described below in conjunction with implementation method.
Implementation method one beneficial Tianjin oral liquid for decreasing blood sugar (potus)
Take by weighing 10 parts of succulent stem of cactus dry products, 2 parts of Radix Ginseng, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 2 parts in Poria, 1 part in Radix Glycyrrhizae at first according to quantity.Clean being cut into of Radix et Caulis Opuntiae Dillenii is no more than 1cm
2Fritter, with the above-mentioned prepared slices of Chinese crude drugs with putting in the extraction pot, add the water (should use distilled water) of 15 times of recipe quantities, in 10-30 ℃ of following soaked overnight (being no less than 8 hours), heat decoction three times.Fried in shallow oil first 2 hours, for the second time, each 1 hour for the third time, decoction liquor is filtered respectively, merge three times and decoct filtrate, in vaporizer when being no more than 100 ℃ of following evaporation and concentration and becoming 20 ℃ the thick paste of relative density 1.10-1.15, add the medicinal alcohol of 2 times of thick paste gross weights, leaving standstill under 0-4 ℃ more than 24 hours, filter, filtering residue is washed 2-3 time with 70% ethanol, and merging filtrate and washing liquid reclaim ethanol, continue to concentrate, at the 100%(g/ml that is no more than 100 ℃ of following evaporation and concentration suitable medical material amount of each component total content to the medicinal liquid) end, under 0-4 ℃, left standstill 48 hours, filter, add to ormal weight with distilled water, mixing is sub-packed in the container of peace bottle that 20ml/ props up or 180ml/ bottle sealing, promptly benefit Tianjin oral liquid for decreasing blood sugar or potus sterilized 30 minutes down for 100 ℃.Every day three times, each 20ml.
Adopt the beneficial Tianjin oral liquid for decreasing blood sugar or the potus of method for preparing, be the slightly heavy-gravity liquid of brownish red, relative density is 1.035-1.055, and pH value is between 4.0-6.0, through transferred three months and after room temperature places 2 years the basic no change of the outward appearance of oral liquid 37-40 ℃ of condition.
Implementation method two beneficial Tianjin oral liquid for decreasing blood sugar (potus)
Take by weighing 50 parts of the bright product of succulent stem of cactus, 2 parts of Radix Ginseng, 2 parts of the Rhizoma Atractylodis Macrocephalaes, 2 parts in Poria, 1 part in Radix Glycyrrhizae at first according to quantity.Radix et Caulis Opuntiae Dillenii cleaned be cut into the piece that is no more than 1cm, it is standby to squeeze its bright juice with squeezer.Again the four flavor prepared slices of Chinese crude drugs such as above-mentioned Radix Ginseng are put in the extraction pot together, the water that adds 10 times of amounts of its total amount, soaked 12 hours down at 10-30 ℃, heating decoction forward direction has soaked adds suitable quantity of water in the medical material, make liquid level exceed medical material 20-30cm, decoct three times, each time was followed successively by 2 hours, 1 hour, 1 hour.Decoction liquor is filtered respectively, merge three times and decoct filtrate, squeeze the juice and decoct the filtrate mix homogeneously above-mentioned, put in the vaporizer thick paste of relative density 1.10-1.15 when being no more than 100 ℃ of following evaporation and concentration and becoming 20 ℃, the medicinal alcohol that adds 2 times of thick paste gross weights, leaving standstill under 0-4 ℃ more than 24 hours, filtering, filtering residue is washed 2-3 time with 70% ethanol, merging filtrate and washing liquid, reclaim ethanol, continue to concentrate, be no more than the 100 ℃ of following evaporation and concentration suitable medical material amount of each component total content 100%(g/ml to the medicinal liquid) end, under 0-4 ℃, left standstill 48 hours, filter, add to ormal weight mixing with distilled water, be sub-packed in the container of peace bottle that 20ml/ props up or 180ml/ bottle, sealing was sterilized promptly benefit Tianjin oral liquid for decreasing blood sugar or potus 30 minutes down for 100 ℃.Every day three times, each 20ml.
Implementation method three beneficial Tianjin hypoglycemic granule agent (electuary)
In the treating excess syndrome applying method one or two evaporation and concentration each component total content to the medicinal liquid be 100%(g/ml) concentrated solution, continued to steam the thick paste of relative density 1.24-1.25 when being condensed into 20 ℃, the starch that adds thick paste gross weight 1/3 amount, mixing, make 20 purpose granules, the temperature drying with being not less than 70 ℃ is distributed into bag, every bag of 5g makes beneficial Tianjin hypoglycemic granule agent (electuary).Obey behind the available heat water dissolution, or use mixing in water for oral taking, each one bag, every day three times.
Implementation method four beneficial Tianjin Jiangtang capsule agent
The thick paste of 20 ℃ of relative density 1.24-1.25 in the treating excess syndrome applying method three, the microcrystalline Cellulose of adding thick paste gross weight 1/3, mixing, make 20 purpose granules, dry under 60-90 ℃, in dried granules packing capsule housing, every 0.5g makes the Jiangtang capsule agent of beneficial Tianjin.Each 4-8 grain when taking, every day three times.
Implementation method five beneficial Tianjin metformins
The thick paste of relative density 1.24-1.25 20 ℃ time the in the treating excess syndrome applying method three, the microcrystalline Cellulose that adds thick paste gross weight 1/3, the hyprolose that adds thick paste and microcrystalline Cellulose gross weight 1/20 again, mixing is made 20 purpose granules, is no more than 70 ℃ of dryings down, in dried granule, add the calcium carboxymethylcellulose of its gross weight 3% and 1% magnesium stearate, mixing is pressed into the sheet of 0.5g, packs into gastric soluble tablet with acrylic resin, makes beneficial Tianjin sugar-tablet.Each 4-8 sheet when taking, every day three times.
Implementation method six beneficial Tianjin oral liquid for decreasing blood sugar (potus)
Take by weighing 40 parts of succulent stem of cactus dry products, 3 parts of Radix Ginseng, 3 parts of the Rhizoma Atractylodis Macrocephalaes, 3 parts in Poria, 1.5 parts in Radix Glycyrrhizae at first according to quantity.All the other preparation methoies are with implementation method one.
Implementation method seven beneficial Tianjin oral liquid for decreasing blood sugar (potus)
Take by weighing 20 parts of succulent stem of cactus dry products, 1.5 parts of Radix Ginseng, 1.5 parts of the Rhizoma Atractylodis Macrocephalaes, 1.5 parts in Poria, 0.5 part in Radix Glycyrrhizae at first according to quantity.All the other preparation methoies are with implementation method one.
Claims (7)
1, a kind of Chinese medicine benefit Tianjin antihypelipidemic preparation for the treatment of diabetes, the weight ratio that it is characterized in that each component in the preparation is succulent stem of cactus dry product 10-40 part, Radix Ginseng 1.5-3 part, Rhizoma Atractylodis Macrocephalae 1.5-3 part, Poria 1.5-3 part, Radix Glycyrrhizae 0.5-1.5 part.
2, the beneficial Tianjin of Chinese medicine according to claim 1 antihypelipidemic preparation is characterized in that the succulent stem of cactus dry product in the preparation can replace with the bright product of succulent stem of cactus, and its consumption is a dry product: bright product=1: 5.
3, a kind of preparation method for the treatment of Chinese medicine benefit Tianjin antihypelipidemic preparation of diabetes, it is characterized in that taking by weighing according to quantity raw materials used, succulent stem of cactus dry product 10-40 part, Radix Ginseng 1.5-3 part, Rhizoma Atractylodis Macrocephalae 1.5-3 part, Poria 1.5-3 part, Radix Glycyrrhizae 0.5-1.5 part are cut into 0.5-5cm with the succulent stem of cactus dry product earlier
2Fritter, with Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, the decoction pieces of Radix Glycyrrhizae is with placing extraction pot, the 10-20 times of water that adds the raw material gross weight, soaked 6-12 hour down at 10-30 ℃, heat fried three times, each 1-3 hour, merge fried liquid, put in the vaporizer, relative density is that the thick paste of 1.10-1.25 ends when being no more than 100 ℃ of following evaporation and concentration and becoming 20 ℃, add thick paste total amount 1-3 medicinal alcohol doubly and carry out precipitate with ethanol, filter the filtering residue washing with alcohol of 40-80%, merging filtrate and washing liquid, reclaim ethanol, in that to be no more than 100 ℃ of following evaporation and concentration each component total content to the medicinal liquid be 50-200%(g/ml) packing, sealing in 100-115 ℃ of sterilization in 15-30 minute, is made medicinal liquid.
4, preparation method according to claim 3, it is characterized in that taking by weighing according to quantity the bright product 50-200 of succulent stem of cactus part, Radix Ginseng 1.5-3 part, Rhizoma Atractylodis Macrocephalae 1.5-3 part, Poria 1.5-3 part, Radix Glycyrrhizae 0.5-1.5 part, earlier the bright product crosscut of succulent stem of cactus is become the long piece of 1-5cm, it is standby to squeeze its bright juice with squeezer; Again with Radix Ginseng, the Rhizoma Atractylodis Macrocephalae, Poria, the decoction pieces of Radix Glycyrrhizae is with placing extraction pot, add four kinds of water that decoction pieces gross weight 8-15 doubly measures, soaked 6-12 hour down at 10-30 ℃, heat fried three times, each 1-3 hour, merge fried liquid, above-mentioned bright juice is mixed with fried liquid, mix thoroughly, put in the vaporizer, relative density is that the thick paste of 1.10-1.25 ends when being no more than 100 ℃ of following evaporation and concentration and becoming 20 ℃, add thick paste total amount 1-3 medicinal alcohol doubly and carry out precipitate with ethanol, filter the filtering residue washing with alcohol of 40-80%, merging filtrate and washing liquid, reclaim ethanol, in that to be no more than 100 ℃ of following evaporation and concentration each component total content to the medicinal liquid be 50-200%(g/ml) packing, sealing in 100-115 ℃ of sterilization in 15-30 minute, is made medicinal liquid.
5, according to claim 3 or 4 described preparation methoies, it is characterized in that the medicinal liquid that will make ends at the thick paste that to be no more than 100 ℃ of relative densities when continuing evaporation and concentration down and becoming 20 ℃ be 1.20-1.30, the medical starch that adds thick paste total amount 1/3-1/5, mixing, make granule, the graininess electuary is made in dry, pack.
6, according to claim 3 or 4 described preparation methoies, it is characterized in that the medicinal liquid that will make ends at the thick paste that to be no more than 100 ℃ of relative densities when continuing evaporation and concentration down and becoming 20 ℃ be 1.20-1.30, the microcrystalline Cellulose or the Powderd cellulose that add thick paste total amount 1/3-1/5, mixing, make granule, dry, be sub-packed in the capsule shells, make capsule.
7, according to claim 3 or 4 described preparation methoies, it is characterized in that the medicinal liquid that will make ends at the thick paste that to be no more than 100 ℃ of relative densities when continuing evaporation and concentration down and becoming 20 ℃ be 1.20-1.30, the cellulose excipient microcrystalline Cellulose or the Powderd cellulose that add thick paste total amount 1/3-1/5, the hyprolose or the calcium carboxymethylcellulose that add thick paste and cellulose excipient gross weight 1/50-1/20 again, mixing, granulate, dry, in dried granule, add the hyprolose of its gross weight 1-30% or the magnesium stearate mixing of calcium carboxymethylcellulose and 0.5-2%, be pressed into tablet, pack into gastric soluble tablet with acrylic resin.
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| Application Number | Priority Date | Filing Date | Title |
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| CN93110152A CN1049341C (en) | 1993-03-09 | 1993-03-09 | Medicinal preparation for promoting secretion of body fluid and lowering sugar and its preparation method |
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| CN93110152A CN1049341C (en) | 1993-03-09 | 1993-03-09 | Medicinal preparation for promoting secretion of body fluid and lowering sugar and its preparation method |
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| CN1076624A true CN1076624A (en) | 1993-09-29 |
| CN1049341C CN1049341C (en) | 2000-02-16 |
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| CN93110152A Expired - Fee Related CN1049341C (en) | 1993-03-09 | 1993-03-09 | Medicinal preparation for promoting secretion of body fluid and lowering sugar and its preparation method |
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Cited By (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000064279A1 (en) * | 1999-04-23 | 2000-11-02 | E Excel International Inc. | Cactus fruit health products |
| US6210738B1 (en) | 1999-04-23 | 2001-04-03 | E Excel Internatioanal Inc. | Freeze-dried ginseng berry tea |
| US6238672B1 (en) | 1999-04-23 | 2001-05-29 | E. Excel International Inc. | Dietary supplements containing dehydrated cactus fruit juice and ginseng berry juice |
| US6524626B2 (en) | 1999-04-23 | 2003-02-25 | E Excel International, Inc. | Ginseng berry topical products |
| US6576286B1 (en) | 1999-04-23 | 2003-06-10 | E Excel International | Cactus fruit drinks and food products |
| CN104224872A (en) * | 2013-06-24 | 2014-12-24 | 山东明仁福瑞达制药股份有限公司 | Health product for regulating blood sugar and blood fat |
| CN105962350A (en) * | 2016-06-23 | 2016-09-28 | 青岛浩大海洋保健食品有限公司 | Plateau opuntia ficus-indica health-care oral liquid with efficacy of preventing and improving diabetes |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100370972C (en) * | 2006-01-10 | 2008-02-27 | 北京申科联华科技有限公司 | Heart boosting pulse restoring tablet and its preparation method |
-
1993
- 1993-03-09 CN CN93110152A patent/CN1049341C/en not_active Expired - Fee Related
Cited By (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2000064279A1 (en) * | 1999-04-23 | 2000-11-02 | E Excel International Inc. | Cactus fruit health products |
| WO2000064278A1 (en) * | 1999-04-23 | 2000-11-02 | E.Excel International, Inc. | Ginseng berry health products |
| US6210738B1 (en) | 1999-04-23 | 2001-04-03 | E Excel Internatioanal Inc. | Freeze-dried ginseng berry tea |
| US6238672B1 (en) | 1999-04-23 | 2001-05-29 | E. Excel International Inc. | Dietary supplements containing dehydrated cactus fruit juice and ginseng berry juice |
| US6524626B2 (en) | 1999-04-23 | 2003-02-25 | E Excel International, Inc. | Ginseng berry topical products |
| US6576286B1 (en) | 1999-04-23 | 2003-06-10 | E Excel International | Cactus fruit drinks and food products |
| CN104224872A (en) * | 2013-06-24 | 2014-12-24 | 山东明仁福瑞达制药股份有限公司 | Health product for regulating blood sugar and blood fat |
| CN105962350A (en) * | 2016-06-23 | 2016-09-28 | 青岛浩大海洋保健食品有限公司 | Plateau opuntia ficus-indica health-care oral liquid with efficacy of preventing and improving diabetes |
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| Publication number | Publication date |
|---|---|
| CN1049341C (en) | 2000-02-16 |
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