US20020077256A1

US20020077256A1 - Novel detergent compositions with enhanced depositing, conditioning and softness capabilities

Info

Publication number: US20020077256A1
Application number: US09/321,074
Authority: US
Inventors: Susan M. Niemiec; Hsing Yeh; Regina Gallagher
Original assignee: Individual
Current assignee: Johnson and Johnson Consumer Inc
Priority date: 1999-05-27
Filing date: 1999-05-27
Publication date: 2002-06-20
Anticipated expiration: 2019-05-27
Also published as: MX221734B; CN1277836A; AU3646500A; CA2309413A1; US6495498B2; EP1080714A2; PH12000000280B1; JP2001002535A; MXPA00005244A; US6858202B2; TWI291875B; EP1080714A3; US6908889B2; US20040157755A1; US20030176303A1; BR0002284A; AU782857B2; KR20010029752A; KR100766731B1

Abstract

Novel one detergent compositions comprised of at least one water soluble silicone agent, at least one cationic condiioning agent, and a detergent. These compostions are suabble for use i sn s, bats, and shower gels. Also descrbed is a novel delivery system for deposbii berneft ar kW snd onto the skin, nails, and/or hair comrn d of at least one water soluble silicone and at least one catonic conditoning agenl

Description

BACKGROUND OF THE INVENTION

1. Field of Invention

The present invention relates to detergent compositions that not only effectively cleanse the hair but also impart superior wet stage and dry stage conditioning properties to the hair in a single application. The present invention is further directed to a novel delivery system for delivering benefit agents onto andlor into the surface of the skin, nails, and/or hair, and methods of using such systems.

2. Backciround of the Invention and Prior Art

Consumers often desire to have a hair shampoo that not only effectively cleanses the hair, but that also imparts other desirable properties, such as conditioning and lathering, to the hair. Because nonionic, amphoteric and zwitterionic surfactants are relatively inferior cleansing surfactants in comparison to anionic surfactants, hair shampoos generally are formulated with the latter, which thoroughly cleanses as opposed to conditions the hair. Hence, hair that has been shampooed with an anionic surfactant-based composition usually appears unconditioned and is considered to be cosmetically unappealing. Furthermore, anionic surfactants adversely leave the hair with an undesirable harsh and “dry to the touch” feel, which is difficult to comb in either the wet or dry state. Even after complete drying, such thoroughly cleansed hair remains unsatisfactory in hair softness and “flyaway” properties. Thus, it is usually necessary to perform a post-shampoo conditioning step to such hair in order to ameliorate these undesirable physical characteristics.

With the advent of so-called “two-in-one” conditioning shampoos, it became possible to condition and cleanse hair simultaneously. However, it is well known that the formulation of such two-inone” conditioning shampoos is difficult due to the inherent incompatibility between the cleansing anionic surfactants and the cationic conditioning agents. Unfortunately, those known “two-in-one” conditioning shampoos that have overcome the incompatibility problem disadvantageously possess inferior cleansing and conditioning properties.

One known method for reducing the incompatibility between the anionic surfactants and the cationic conditioning agents is through the use of altemative, non-anionic surfactants and improved cationic conditioning agents. However, such alternative, non-anionic surfactants possess relatively inferior cleansing properties.

Other efforts have concentrated on varying the types of conditioners. Cationic conditioning agents disadvantageously do not generally provide optimal overall conditioning benefits, particularly in the areas of “softness” and “wet/dry combing”, when delivered as an ingredient in a shampoo composition. Water-insoluble conditioning agents, such as the non-volatile silicones that are well recognized in the art as providing a degree of softness to the hair, often results in unstable “two-inone” formulations. See U.S. Pat. No. 4,704,272; U.S. Pat. No. 4,741,855; and U.S. Pat. No. RE 34,584. Substantive cationic polymers, which are capable of depositing on the hair shaft during shampooing to impart the desired degree of manageability, disadvantageously result in formulations that give the hair a greasy feeling or “build-up” on hair. See U.S. Pat. No. 5,221,530; U.S. Pat. No. 5,417,965; U.S. Pat. No. 4,292,212; and U.S. Pat. No. 4,472,297.

Another important property of cleansing compositions that is desired by consumers is lathering. Consumers often associate high lathering with effective cleansing, and typically prefer high lathering shampoos to low lathering shampoos from an aesthetic standpoint. Unfortunately, many therapeutic shampoos, in particular those possessing therapeutic agents such as anti-dandruff agents, contain active agents that tend to adversely affect lathering performance. Kt is well known that the deposition of therapeutic agents on the hair or skin may be improved via significantly increasing the levels of therapeutic agents in the shampoo compositions. However, not only does the use of such high levels therapeutic agents disadvantageously increase raw materials costs, but also it also reduces the latherability of the shampoo and deleteriously affects product stability. The presence of detergents in the anti-dandruff shampoos also interferes with the ability of therapeutic agents to deposit onto the hair because the detergents are designed to carry or remove oil, grease, dirt, and particulate matter from the hair and scalp during rinsing.

Accordingly, it would be highly desirable to find a “twG-in-one” cleansing composition capable of effectively cleansing and detangling the hair while imparting superior wet and dry combing and softness thereto, without creating “build-up”. It would also be desirable to have a high-lathering “two-in-one” cleansing composition that not only effectively cleansed the hair but also deposited a significant amount of therapeutic agents onto the hair and skin.

SUMMARY OF THE INVENTION

In accordance with this invention, there is provided a cleansing composition comprising, cons essentially of, and/or consisng of

a) at least one water soluble silicone agent;

b) at least one cationic conditioning agent; and

c) at least one detergent.

Another embodiment of the present invention is directed to a delivery system for delivering benefit agents into and/or onto the hair, nails, and scalp comprised of, consisting essentially of, and/or consisting of

a) at least one water soluble silicone agent; and

b) at least one cationic conditioning agent.

Another embodiment of the present invention is directed to a method for enhancing the deposition of benefit agents which comprises, consists essentially of, and/or consists of topically administering to a human or animal a composition comprised of, consists essentially of, and/or consists of:

a) a delivery system comprised of

i) at least two cationic conditioning compounds selected from the group consisting of guar hydroxypropyltrimonium chloride, acrylaminopropyltrimonium chloride/acrylamide copolymer, and mixtures thereof;

ii) at least one water soluble silicone compound comprised of silicone quatemium-1 3; and

b) an effective amount of a benefit agent to a desire location on the skin, hair, and/or nails.

Yet another embodiment is directed to a method for depositing a thin coating of conditioner on a hair fiber, comprised of, consisting essentially of, and/or consisting of:

a) topically applying an effective amount of a delivery system composition comprised of

ii) at least one water soluble silicone compound comprised of cetyl triethylmonium dimethicone copolyol phthalate; and

iii) a hydrophilic benefit agent to a desired location on the hair of a human or animal.

Yet another embodiment is directed to a method for treating hair loss comprising, consists essentially of, and/or consisting of topically administering to a human or animal at a desired area for treating hair loss a composition comprised of, consisting essentially of, and/or consisting of based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

ii) at least one cationic conditioning agent; and

B. an effective amount of a hair loss treatment agent.

Another embodiment is directed to a method for inhibiting hair growth comprising, consisting essentially of, and/or consisting of topically administering to a human or animal at a desired area for inhibiting hair growth a composition comprised of, consisting essentially of, and/or consisting of, based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

ii) at least one cationic conditioning agent; and

B. an effective amount of a hair growth inhibiting agent.

Another embodiment of the present invention is directed to a method for treating or minimizing the effects of aging comprising, consisting essentially of, and/or consisting of topically administering to a human or animal at a desired area a composition comprised of, consisting essentially of, and/or consisting of based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

ii) at least one cationic conditioning agent; and

B. an effective amount of an anti-aging active agent.

Another embodiment of the present invention is directed to a method for treating acne comprising, consisting essentially of, and/or consisting of topically administering to a human or animal at a desired area a composition comprised of, consisting essentially of, and/or consisting of, based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

i) at least one cationic conditioning agent; and

B. an effective amount of an anti-acne active agent.

Another embodiment of the present invention is directed to a method for depigmenting skin comprising, consisting essentially of, and/or consisting of topically administering to a human or animal at a desired area a composition comprised of, consisting essentially of, and/or consisting of based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

ii) at least one cationic conditioning agent; and

B. an effective amount of a depigmentation active agent.

In yet another embodiment of the present invention is a method for treating the diseases of dandruff, seborrheic dermatitis, and psoriasis and/or the symptoms associated therewith comprising, consisting essentially of, and/or consisting of topically administering to a human or animal at a desired area a composition comprised of, consisting essentially of, and/or consisting of based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

ii) at least one cationic conditioning agent; and

B. an effective amount of a benefit agent selected from the group consisting of an anti-dandruff agent, an antiseborrheic dermatitis agent, an antipsoriasis agent, and mixtures thereof.

The composition of this invention, when used in a shampoo or body cleanser, possesses one or more of the following properties: lathering, cleansing, wet detangling, wet combining, dry combing, conditioning, softness, manageability, nnseability, and ability to significantly deposit therapeutic agents. Moreover, the delivery system of the present invention is capable of effectively depositing benefit agents into and/or onto the skin, hair and nails.

BRIEF DESCRIPTION OF THE DRAWINGS

The above and other aspects and novel features of the present invention will become apparent from the following detailed description of the preferred embodiments, as illustrated in the accompanying figures showing the improved hair conditioning properties imparted by using the method and composition of the present invention, wherein: [0058]
FIG. 1([0059] a) is a mass spectrometric representation of a hair fiber previously treated with Pantene Pro-V shampoo.
FIG. 1([0060] b) is a mass spectometric representation of a hair fiber previously treated with a cleansing composition of the present invention as described in Example 11.

DETAILED DESCRIPTION OF PREFERRED EMBODIMENTS

In one embodiment of the present invention, the cleansing composition may suitably comprise, consist of, or consist essentially of: a) at least one water soluble silicone agent; b) at least one cationic conditioning agent; and c) at least one detergent. Preferably, the cleansing composition contains, based upon the total weight of the cleansing composition, a) from about 0.001 percent to about 20 percent, and preferably from about 0.01 percent to about 5 percent of water soluble silicone agents; b) from about 0.01 percent to about 10 percent, and preferably from about 0.1 percent to about 5 percent of cationic conditioning agents; and c) from about 0.01 percent to about 30 percent, and preferably from about 5 percent to about 20 percent detergent. [0061]
The first component of the cleansing composition is a water soluble or insoluble silicone agent, with water soluble silicone agents being preferred. Examples of suitable water soluble silicone agents nonexdusively include the water soluble dimethicones substituted with fatty acid moieties, water soluble silicone quatemiums, and mixtures thereof. Either volatile or nonvolatile water soluble silicones are suitable for use in the present invention, with the latter being preferred. Preferably, the water soluble dimethicones are substituted with fatty acid moieties selected from fatty acids having from about 5 carbon atoms to about 30 carbon atoms and the silicone quatemiums contain about 6 carbon atoms to about 20 carbon atoms. [0062]
Examples of suitable water soluble volatle silicone agents nonexcusiely indude polydimethylilo:ane, hexamethyidisiloxne, cyclomethicone fluids such as polydiknethylcyclosloxane available commercially from Dow Coming Corporaton of Midland, Michigan under the tradename, “DC-345” and mixtures thereof, with the cyclomethicone fluids being preferred. [0063]
Examples of suitable water soluble nonvolatile silicone agents nonexdusively include cetyl triethylmonium dimethicone copolyol phthalate, stearalkonium dimethicone copolyol phthalate, dimethicone copolyol having the following structure I.: [0064]
Wherein: [0065]
q′ is an integer from about 1 to about 7000; [0066]
q″ is an integer from about 1 to about 5000; [0067]
R[0068] ₉may be any water soluble group such as:
a) a fatty alcohol having from about 8 carbon atoms to about 30 carbon atoms; [0069]
b) a fatty acid having from about 8 carbon atoms to about 30 carbon atoms, and derivatives thereof; [0070]
c) a crosslinked water soluble polymer such as mercaptol propyl copolymer; [0071]
d) a cationic moiety, e.g. trimonium chloride; [0072]
e) propyl PG Betaine; [0073]
f) polypeptides such as polysarcosine, and [0074]
e) mixtures thereof, [0075]
dimethicone copolyol acetate, dimethicone copolyol lactate, dimethicone copolyol laurate, dimethicone copolyol methyl ether, dimethicone copolyol octyl dodecyl citrate, hydrolyzed soy proteinidimethicone copolyol acetate, dimethiconol, and mixtures thereof. [0076]
Examples of suitable water soluble silicone quatemiums nonexclusively include silicone quatemium 13, silicone quatemium 40, quatemium 80 and mixtures thereof, as well as those silicone quatemiums disclosed in U.S. Pat. No. 5,098,979, which is incorporated by reference herein in its entirety. [0077]
More preferred water soluble silicone agents include silicone quatemium 13, cetyl triethylmonium dimethicone copolyol phthalate, stearalkonium deimethicone copolyol phthalate, and mixtures thereof. [0078]
The second component in the composition of the present invention is a cationic conditioning agent such as a cationic cellulose derivative; a cationic guar derivative; a homopolymer or copolymer of a cationic monomer selected from: [0079]
a. a monomer having the formula II. [0080]
wherein [0081]
R is H or CH[0082] ₃,
Y is O or NH, [0083]
R[0084] ₁is an alkylene group having from about 2 to about 6 carbon atoms,
R[0085] ₂, R₃and R₄are each independency an alkyl group or hydroxyalkyl group having from about 1 to about 22 carbon atoms, and
X is a monovalent anion selected from halide and alkyl sulfate hawt from about 1 to about 4 carbon atoms, or [0086]
b. diallyidimethylammonium chloride, or mixtures thereof. [0087]
A suitable cationic cellulose derivative is the polymeric quatemary ammonium saft derivd from the reaction of hydroxyethyl cellulose with a trimethylammonium substituted epoxide. The material known as Polyquatemium-10, commercially available from Amerchol Corporation of Edison, N.J. as “Polymner JR-400,” is especially useful in this regard. [0088]
The cationic guar derivative is preferably a guar hydroxpropytrimonium chloride, available comnmercially from Rhone-Poulenc Inc., of Cranbury, N.J. under the tradename, OJaguar C-17.” [0089]
Another suitable cationic polymer indudes those compounds denved from acrayamidopropyl trimonium chloride which has the formula III.: [0090]
and more preferably is the copolymer of this monomer with acrylamide, the latter of which is available commercially from Allied Colloids, of Suffolk, Va. under the tradename, uSalcare SC60.”[0091]
Other suiae cationic conditioning polymers are those deried from the monomer diallyidirnethylammonium chloride. The homopolymer of this monomer is Polyquatemium-6, which is available cornme illy from Allied Colloids of Suffolk, Va. under the tradename, usalcare 530.” The copolymer of diallyidimethylammonium chloride with acrylamide is known as Polyquatemr7, and is also available from Allied Colloids under the tradename “Salcare SC10.” Other suitable polymers include polyquatemium47, which is available from Calgon Corporation under the tradename, “MERQUAT 2001 N.”Most preferred cationic conditioning agents include acrylamidopropyltrimonium chloridelacrylamide copolymer, guar hydroxypropyltrimonium chloride, and mixtures thereof. [0092]
The third component in the composition of the present invention is a detergent. By “detergent,” it is meant any known surfactant and/or soap that is compatible with the silicone agents and the cationic agents of the cleansing composition, and may nonexclusively include anionic surfactants, nonionic surfactants, cationic surfactants, amphoteric surfactants (including betaine surfactants and zwitterionic surfactants) and mixtures thereof. [0093]
Examples of suitable anionic surfactants include, but are not limited to, compounds in classes known as alkyl sulfates, sulfate esters of an alkylphenoxy polyoxyethylene ethanol, alpha-olefin sulfonates, betaalkyloxy alkane sulfonates, alkyl arylsulfonates, alkyl carbonates, alkyl ether carboxylates, fatty acids, sulfosuccinates, alkyl ether sulfosuccinates, sarcosinates, octoxynol phosphates, nonoxynol phosphates, taurates, fatty taurides, sulfated monoglycerides, fatty acid amido polyoxyethylene sulfates, and isethionates and mixtures thereof. Many additional surfactants are described in WO 07/26860 and in McCUTCHEON“S DETERGENTS AND EMULSIFIERS (1989), which are both incorporated herein by reference. These anionic surfactants are generally present in the composition as a neutralized salt in the form of sodium salts, potassium salts, ammonium salts, lithium salts, alkyl ammonium salts, or hydroxyalkyl ammonium salts. Preferred anionic surfactants are alkyl sulfates, alkyl ether sulfates, alkyl phosphates, amino acid salts such as N-acyl-L-glutamate, x-olefin sulfonates, alkyl sarcosinates, alkyl benzene sulfonates, acyl isethionates, alkyl sulfosuccinates, acyl methyl taurides, and mixtures thereof, with sodium C14-16 olefin sulfonate, ammonium lauryl sulfate, sodium trideceth sulfate, sodium laureth sulfate, disodium laureth sulfosuccinate being most preferred. [0094]
Examples of suitable nonionic surfactants include, but are not limited to, those set forth in WO 07/26860, with polysorbate 20, long chain alkyl glucosides having alkyl groups containing about 8 carbon atoms to about 22 carbon atoms; coconut fatty acid monoethanolamides such as cocamide MEA; coconut fatty acid diethanolamides, and mixtures thereof, being most preferred. Any amount of cationic surfactants or non-ionic surfactants employed in the detergent base are in addition to the amount of the non-ionic surfactant or cationic surfactant, respectively, that may be included in the vesicle bilayer. [0095]
Examples of suitable cationic surfactants include, but are not limited to, those set forth in WO 07/26860, as well as the quaternary ammonium surfactants and quaternary amine surfactants that are not only positively charged at the pH of the shampoo composition, which generally is about pH 10 or lower, but also are soluble in the shampoo composition. Preferred cationic surfactants nonexusively include the n-acylamidopropyl dimethylamine o)xdes such as cocamidopropylamine o)xde sold commercially under the tradename “Incromine Oxdde C” available from Croda Inc. Parsippany, N.J. [0096]
Examples of suitable amphoteric surfactants include, but are not limied to, those set forth in WO 07/26860, i.e., amphocarboxylates, alkyl betaines, amidoalkylbetaines, amidoalkylsultaines, amphophosphates, phosphobetaines, pyrophosphobetaines, carboxyalkyl alkyl polyamines, and mxbdures thereof. Preferred amphoteric surfactants include amidoalkylbetaines such as cocamidopropyl betaine available commercially from Goldschmidt Chemical Corporation of Hopewell, Viinia under the tradename “Tegobetaine E”; alkyl imidazoline having from about 8 carbon atoms to about 18 carbon atoms in the alkyl group such as Sodium Cocoamphopropionate available commercially from Mona Industries Inc. of Paterson, N.J. under the tradename “Monateric CA-35”. [0097]
Examples of suitable soaps include fatty acids reacted with potassium, sodium, ammonium, lithium, or a triethanol amine base to form soaps such as, e.g., sodium cocoate or triethanolamine cocoate. [0098]
In a preferred embodiment, the detergent is comprised of a mbdure of, based upon the total weight of the detergent, from about 0.1 percent to about 30 percent, and preferably from about 1 percent to about 20 percent anionic surfactants, from about 0 percent to about 10 percent, and preferably from about I percent to about 7 percent nonionic surfactants, from about 0 percent to about 10 percent, and preferably from about 0 percent to about 4 percent cationic surfactants, and from about 0 percent to about 15 percent, and preferably from about 1 percent to about 10 percent amphoteric surfactants. [0099]
In another preferred embodiment, the cleansing composition is comprised of, based upon the total weight of surfactant, from about 50 percent to about 99 percent, and preferably from about 80 percent to about 95 percent, of anionic surfactants preferably selected from the group consisting of alkyl sulfates, alkyl ether sulfates, and mixtures thereof wherein the alkyl group has from about 8 carbon atoms to about 18 carbon atoms, and from about 1 percent to about 20 percent, and preferably from about 5 percent to about 15 percent of amphoteric surfactants, preferably cocamidopropyl betaine. [0100]
In another preferred embodiment, the cleansing composition is comprised of, based upon the total weight of surfactant, from about 50 percent to about 99 percent, and preferably from about 70 percent to about 90 percent, of anionic surfactants, preferably those selected from the group consisting of sodium PEG7 olive oil carbonate, alkyl sulfates, alkyl ether sulfates, and mixtures thereof wherein the alkyl group has from about 8 carbon atoms to about 18 carbon atoms; from about 1 percent to about 30 percent, and preferably from about 10 percent to about 25 percent of an amphoteric surfactant preferably selected from the group consisting of cocamidopropyl betaine and mixtures thereof; and optionally, from about 0 percent to about 15 percent, and preferably from about 2 percent to about 10 percent of a cationic surfactant such as cocammoniumcarbomoyl chloride. [0101]
In embodiments wherein a particulate compound, such as several of the antidandruff agents, e.g. zinc pyrithione, that tends to precipitate out of the solution is combined with the cleansing composition, the surfactant is preferable employed in conjunction with a suspending agent, with the latter having the ability of suspending the particulate compound. In those embodiments, the suspending agent-cntaining cleansing composition may be made by either 1) simultaneously combining the suspending agent with the detergent, the silicone agents, and the cationic conditioners, or preferably, 2) pre-mixing the suspending agent with the detergent component, then combining the resulting mbdure with the silicone agents and the catioric conditioners. [0102]
Examples of suitable suspending agents nonexclusively include: 1) acrylate polymers and copolymers thereof such as the Acrylates/Aminoacrylates Cl 030 Alkyl PEG20 Itaconate copolymer available commercially from National Starch and Chemical Corporation of Bridgewater, N.J. under the trade name “Structure Plus”; 2) fatty acyl derivatives, wherein the acyl group has the structure IV: [0103]
wherein R[0104] ₁₀comprises a carbon chain having from about 7 carbon atoms to about 21 carbon atoms that is either saturated or unsaturated and is either substituted or unsubstituted with, for example, hydroxy groups; 3) esters of long chain fatty acids, wherein the fatty acids have the structure V:
wherein R[0105] ₁₁is an alkyl group having from 8 carbon atoms to about 30 carbon atoms, and R,₂is an alkyl group having from 8 carbon atoms to about 30 carbon atoms, such as stearyl stearate ; 4) alkyl dimethylamine o)xdes wherein the alkyl group has from about 8 carbon atoms to about 18 carbon atoms as disclosed in U.S. Pat. No. Re. 34,584, which is incorporated by reference herein in its entrety; 5) methylvinylether/maleic anhydride copolymer crosslinked with 1 ,9-decadiene PolyVM/MA (PVM/MA decadiene crosspolymer) available from International Specialty Products under the tradename, “Stabileze 06 & QM;”6) cellulose derivatives such as methylcellulose, hydroxybutyl methylcellulose, hydroxypropylcellulose, hydroxypropyl methylcellulose, hydroxyethyl ethylcellulose, hydroxyethyl cellulose, and mixtures thereof; 7) Distearyl Phthalic Amide available from Stepan Company under the tradename “Stepan SAB-2,” 8) Di(hydrogenated) Tallow Phthalic Amide available from Stepan Company under the tradename “Stepan TAB2”; 9) primary amines having a fatty alkyl group with at least about 16 carbon atoms such as palmitate amine and stearamine; 10) polyacrylic acids such as carbomers, which are available from B. F. Goodrich Company under the tradename, “Carbopol”; 11) polysaccharide gums such as xanthan gum; 12) colloidal clays such as benzyl dimethyl hydrogenated tallow ammonium montmorillonite (Bentone 27); 13) colloidal silica; and 14) mixtures thereof. Examples of suitable fatty acyl derivatives include ethylene glycol distearate, ethylene glycol monostearate, and alkanolamides such as cocamide MEA, and mixtures thereof.
Preferred suspending agents include carbomer, hydroxyethyl cellulose, methylvinyletherlmaleic anhydride copolymer crosslinked with 1 ,9-decadiene PolyVMtMA (PVMIMA decadiene crosspolyrner), and Acrylates/Aminoacrylates C1030 Alkyl PEG20 ftaconate Copolymer, with Acrylates/Aminoacrylates C10-30 Alkyl PEG20 Itaconate Copolymer being most preferred. [0106]
The suspending agent is preferably used in an amount effective for suspending the particulate compound. Although such amount may vary dependent upon, for example, the type of particulate compound selected, the viscosity of the formulation desired, and the stability of the formulation, typically the amount of suspending agent may range, based upon the total weight of the detergent, from about 0 percent to about 5 percent, and preferably from about 0.01 percent to about 1 percent. [0107]
Other optional ingredients that may be included in the cleansing composition nonexIusiwly include commercially available pearlescent or opacifyng agents, thickeners, chelating agents, colorants, fragrances, preservatives, pH adjustors, conditioning agents, and mixtures thereof. [0108]
Suitable pearlescent or opacng agents which are respectively present in an amount, based upon the total weight of the composition, of from about 0 percent to about 3 percent, preferably from about 025 percent to about 2.5 percent, and more preferably, from about 0.5 percent to about 1.5 percent Examples of suitable pearlescent or opaciylng agents include, but are not limited to mono or diesters of ([0109] a) fatty acids havig from about 16 to about 22 carbon atoms and lb) either ethylene or propylene glycol; mono or diesters of (a) faty acids having from about 16 to about 22 carbon atoms (b) a polyalkylene glycol of the formula X.:
HO—(JO)_a—H X.
wherein [0110]
J is an alkylene group having from about 2 to about 3 carbon atoms; and [0111]
a is 2or 3; [0112]
fatty alcohols containing from about 16 to about 22 carbon atoms; fatty esters of the formula Xl: [0113]
KCOOCH₂L XI.
wherein K and L independently contain from about 15 to about 21 carbon atoms; [0114]
inorganic solids insoluble in the shampoo composition, and mixtures thereof. [0115]
In a preferred embodiment, the pearlescent or opacifyig agent is introduced to the shampoo composition as a preformed, stabilized aqueous dispersion, such as that commercially available from Henkel Corporation of Hoboken, N.J. under the tradename, “Euperlan PK-3000.” This material is a combination of glycol distearate (the diester of ethylene glycol and stearic acid), Laureth-4 (CH[0116] ₃(CHO₁o (OCH₂CH₂)₄OH) and cocamidopropyl betaine and preferably is in a weight percent ratio of from about 25 to about 30: about 3 to about 15: about 20 to about 25, respectively.
Examples of suitable chelating agents include those which are capable of protecting and preservng the composiins of this invention. Preferably, the chelating agent is EDTA, and more preferably is tetrasodium EDTA avilable commercially from Dow Chemical Company of Midland, Mich. under the tradename, “Versene 100XL” and is present in an amount, based upon the total weight of the composition, from about 0 to about 0.5 percent and preferably from about 0.05 percent to about 025 percent. Other suitable chelating agents include parabens such as methyl paraben, propyl paraben, butl paraben, isomethyl paraben, isopropyl paraben, isobuWl paraben, sodium benzoate, iodopropynyl butylcarbamate which is commercially avalable as “Glycaci L” from Lonza, Inc., and mixtures thereof. Suitable preservatives include Quatemium-15, avalable commieally as “Dowici 200” frm the Dow Chemical Corporation of Midland, Mich., and are present in the m on in an amount, based upon the total weight of the composition, from about 0 to about 02 percent, and preferably from about 0.05 percent to about 0.10 percent [0117]
The above described cleansing composition may be prepared by combining the desired components in a suitable container and minng them under ambient conditions in any conventional mixng means well known in the art, such as a mechanically stirr propeller, paddle, and the like. Although the order of mi ng is not critical, it is preferable to preblend certain components, such as the fragrance and the nonionic surfactant before adding such components into the main mbdure. [0118]
The composition of this invention can be formulated in a variety of dosage forms for topical application that include, but are not limited to, for example, washes, baths, lotions, creams, ointments, sprays, aerosols, skin patches, soap, mousses, tonics, gels, solids (e.g. sticks) or the like which is designed to be left on the skin and not washed shortly after application. Alternatively, the composition may be applied to the desired area in the form of, for example, a lotion, cream, gel, soap, shampoo or the like which is designed to be rinsed off within a given amount of time after application. [0119]
Another preferred embodiment of the present invention is directed to a delivery system for delivering benefit agents to the hair, nails, and scalp comprised of a) at least one water soluble silicone agent; and b) at least one, and more preferably at least two cationic conditioning compounds. Preferably, the delivery system is comprised of, based upon the total weight of the delivery system, a) from about 0.001 percent to about 10 percent, and preferably from about 0.01 percent to about 5 percent of at least one water soluble silicone agent; and b) from about 0.001 percent to about 5 percent, and preferably from about 0.01 percent to about 2 percent of at least one, and preferably at least two cationic conditioning compounds. [0120]
In embodiments wherein it is desirable to deposit hydrophilic benefit agents, e.g. salicylic acid, alpha hydroxy acids, vitamins, proteins, and peptides, onto and/or into the skin, hair, and nails, it is preferable to apply thereto the benefit agent in the delivery system composition comprised of at least two cationic conditioning compounds, which preferably are guar hydroxypropyltrimonium chloride and acrylaminopropyltrimonium chloride/acrylamide copolymer; and more preferably with the combination of at least 2 cationic conditioning compounds, which are preferably guar hydroxypropyltrimonium chloride and acrylaminopropyltrimonium chloride/acrylamide copolyner, and at least one water soluble silicone compound, which preferably is a silicone quatemium-13. It is most preferable to apply the hydrophilic benefit agent in a delivery system comprised of at least 2 cationic conditioning compounds, which preferably are guar hydroxypropyltrimonium chloride and acrylamidopropyltrimonium chloride/acrylamide copolymer, and at least two water soluble silicone compounds, one of which is preferably a silicone quatemium-13. [0121]
In embodiments wherein it is desirable to deposit hydrophobic benefit agents, Le. elubiol, kebconazole, retiol and dervati thereof, onto and/or into the skin, nails, and/or hair, it is preferable to apply thereto the hydrophobic benefit agent in a delivery system composition comprised of at least 2 cationic condiioning compounds, which preferably are guar hydroxypropyltrimonium chloride and acrylamiiopropyltrimonium chloride/acrylamide copolymer and at least one water soluble silicone compound, which preferably is a silicone quatemium-13. It is more preferable to apply the hydrophobic benefit agent in a delivery system comprised of at least 2 cationic conditioning compounds, which preferably are guar hydroxypropytimonium chloride and acrylamidopropyltrimonium chloride/acrylamide copolymer, and at least two water soluble silicone compounds, one of which is preferably a silicone quatemium-13. [0122]
In embodiments wherein it is desirable to deposit a thin coating of conditioner on the hair fiber, it is desirable to apply thereto a composition comprised of at least two cationic agents and at least one water soluble silicone, the latter of which preferably is cetyl triethylmonium dimethicone copolyol phthalate. Suitable depositing conditioners nonexdusively include the silicone agents and cationic conditioning agents described herein as well as other known conditioners. [0123]
In addition to combining a benefit agent along with the delivery system, another embodiment of the present invention is directed to combining an optional benefit agent along with the above-described cleansing composition. By “benefit agent,” it is mean any active ingredient that is to be delivered into and/or onto the skin at a desired location, such as a cosmetic agent or a pharmaceutical agent. By “cosmetic agent,” it is meant any ingredient that is appropriate for cosmetically treating, providing nutrients to, and/or conditioning the hair and/or skin via topical application. By “pharmaceutical agent,” it is mean any drug that is either hydrophobic or hydrophilic in nature and appropriate for topical use. As used herein “medicament agents” include those agents capable of promoting recovery from injury and illness. [0124]
Examples of suitable benefit agents include, but are not limited to, depigmentation agents; reflectants; thickening agents; detanglingtwet combing agents; film forming polymers; humectants; amino acid agents; antimicrobial agents; allergy inhibitors; anti-acne agents; anti-aging agents; anti-wrinkling agents, antiseptics; analgesics; antitussives; antipruritics; local anesthetics; anti-hair loss agents; hair growth promoting agents; hair growth inhibitor agents, antihistamines; antuinfectives; inflammation inhibitors; anti-emetics; anticholinergics; vasoconstrictors; vasodilators; wound healing promoters; peptides, polypeptides and proteins; deodorants and antiperspirants; medicament agents; skin emollients and skin moisturizers; hair conditioners; hair softeners; hair moisturizers; vitamins; tanning agents; skin lightening agents; antifungals such as antifungals for foot preparations; depilating agents; shaving preparations; eaemal analgesics; perfumes; counterirritants; hemorrhoidals; insecticides; poison ivy products; poison oak products; bum products; anti- diaper rash agents; prickly heat agents; make-up preparations; vitamins; amino adds and their derivatives; herbal exracts; retinoids; flavoids; sensates; anti-oxdants; skin conditioners; hair lighteners; chelating agents; cell turnover enhancers; coloring agents; pigments; sunscreens and the like, and mixtures thereof. The amount of certain cleansing compostikon/delivery system compounds for the benefit agent purposes set forth below is in addition to the amount of the same compound that may be desired for use in the cleansing composition/delivery system therefor. [0125]
Examples of suitable reflectants nonexcusively include mica, alumina, calcium silicate, glycol dileate, glycol distearate, silica, sodium magnesium fluorosilicate, and mixtures thereof. [0126]
Examples of suitable UV absorbers include benzophenone, bomelone, butyl paba, cinnamidopropyl trimethyl ammonium chloride, disodium distyryibiphenyl disulfonate, paba, potassium methoxydnnamate, and mixtures thereof. [0127]
Commercially available thickening agents that are capable of imparting the appropriate *i”, to the conditioning shampoo compositions are suitable for use in this invention. If used, the thickener should be present in the shampoo compositions in an amount sufficient to raise the Brookfield viscosity of the composition to a value of between about 500 to about 10,000 centipoise. Examples of suitable thickening agents nonexcusiely include: mono or diesers of polyethylene glycol of formula VI. [0128]
HO—(CH₂CH₂O)_zH VI.
wherein z is an integer from about 3 to about 200; [0129]
fatty acids containing from about 16 to about 22 carbon atoms; fatty acid esters of ethoxylated polyols; ethoxylated deiiaties of mono and diesters of fatty acids and glycerine; hydroxyalkyl cellulose; alkyl cellulose; hydroxyalkyl alkyl cellulose; and mixtures thereof. More specifically, suitable thickening agents nonevdusvely include behenalkonium chloride; cetyl alcohol, quatemium 46, PG-hydroxyethyl cellulose, cocodimonium chloride, polyquatemium 6, polyquatemium 7, quatemium 18, PEG-18 glycerol oleatelcocoate, a mbdure of acrylatestspirit 50 acrylate copolymer, laureth 3 and propylene glycol, which is commercially available from Goldschmidt under the tradename “Antil 208,” a mbdure of cocamidopropylbetaine and glyceryl laurate which is commercially available from Goldschmidt under the tradename, “Antil HS60,” a mbdure of propylene glycol, PEG 55, and propylene glycol oleate, which is commercially available from Goldschmidt under the tradename, “Antil 414 liquid,” and mixtures thereof. Preferred thickeners include polyethylene glycol ester, and more preferably PEG-150 distearate which is available from the Stepan Company of Northfield, Illinois or from Comiel, S.pA. of Bologna, Italy under the tradename, “PEG 6000 DS”. [0130]
Suitable detanglingtwet combing agents nonexclusively include dioleoylamidoethyl hydroxythylmonium methosulfate, di (soyoylethyl) hydroxyethylmonium methosulfate, hydroxyethyl behenamidopropyl dimonium chloride, olealkonium chloride, polyquatemium 47, stearalkonium chloride, tricetylmonium chloride, and mixtures thereof. [0131]
Suitable film forming polymers include those that, upon drying, produce a substantially contkuous coating or flm on the hair, skin, or nails. Nonecusive examples of suitable film forming polymers indude acrylamidopropyl trimonium chloride/acrylamide copolymer; corn starch/ acrylamidel sodium acrylate copolymer; polyquatemium 10; polyquatemium 47; polyvinylmethyl/maleic anhydride copolymer; styrene/acrylates copolymers; and mixures thereof. [0132]
Commercially amailable humectants which are capable of providing moisturrzatn and conditioning properties to the deansing composition are suitable for use in the present invention. The humectant is preferably present in an amount of from about 0 percent to about 10 percent, more preferably from about 0.5 percent to about 5 percent, and most preferably from about 0.5 percent to about 3 percent, based on the overall weight of the composition. Examples of suitable humectants nonexcusively indude: 1) water soluble liquid polyols selected from the group comprising glycerine, propylene glycol, he)yene glycol, butylene glycol, pentylene glycol, dipropylene glycol, and mixtures thereof; 2) polyalkylene glycol of the formula VII: [0133]
HO—(R″O)_b—H VII.
wherein R″ is an alkylene group having from about 2 to about 4 carbon atoms and b is an integer of from about 1 to about 10, such as PEG 4; 3) polyethylene glycol ether of methyl glucose of formula VIII: [0134]
CH[0135] ₃—C₆H₁₀O₅—(OCH₂CH₂)_c—OH VIII
wherein c is an integer from about 5 to about 25; [0136]
4) urea; 5) fructose; 6) glucose; 7) honey; 8) lactic acid; 9) maltose; 10) sodium glucuronate; and 11) mixtures thereof, with glycerine being the preferred humectant. [0137]
Suitable amino acid agents include amino acids derived from the hydrolysis of various proteins as well as the salts, esters, and acyl derivatives thereof. Examples of such amino acid agents nonexcusively include amphoteric amino acids such as alkylamido alkylamines, i.e. stearyl acetyl glutamate, capryloyl silk amino acid, caprylol collagen amino acids; capryloyl kertain amino acids; capryloyl pea amino acids; cocodimonium hydroxypropyl silk amino acids; corn gluten amino acids; cysteine; glutamic acid; glycine; hair keratin amino acids; hair amino acids such as aspartic acid, threonine, serine, glutamic acid, proline, glycine, alanine, half-cystine, valine, methionine, isoleucine, leucine, tyrosine, phenylalanine, cysteic acid, lysine, histsline, arginine, cysteine, tryptophan, citrulline; lysine; silk amino acids, wheat amino acids; and mixtures thereof [0138]
Suitable proteins include those polymers that have a long chain, i.e. at least about 10 carbon atoms, and a high molecular weight, i.e. at least about 1000, and are formed by self-condensation of amino acids. Nonexcusive examples of such proteins include collagen, deoxyribonuclease, iodized corn protein; keratin; milk protein; protease; serum protein; silk; sweet almond protein; wheat germ protein; wheat protein; wheat protein, alpha and beta helix of keratin proteins; hair proteins, such as intermediate filament proteins, high-sulfur proteins, ultrahigh-sulfur proteins, intermediate filament-associated proteins, high-tyrosine proteins, high-glycine tyrosine proteins, tricohyalin, and mixtures thereof. [0139]
Examples of suitable vitamins nonexclusively include vitamin B complex including thiamine, nicotinic acid, biotin, pantothenic acid, choline, riboflavin, vitamin B6, vitamin B12, pyridoxine, inositol, camiline; vitamins A,C,D,E,K and their deriatives such as vitamin A palmitate and pro-vitamins, e.g. (i.e. panthenol (pro vitamin B5) and panthenol triacetate) and mixtures thereof. [0140]
Examples of suitable antibacterial agents nonexusiwely include bacitracin, erythromycin, neomycin, tetracycline, chlortetracycline, benzethonium chloride, phenol, and mixtures thereof. [0141]
Examples of suitable skin emollients and skin moisturizers nonexlusively include mineral oil, lanolin, vegetable oils, isostearyl isostearate, glyceryl laurate, methyl gluceth 10, methyl gluceth 20 chitosan, and mixtures thereof. [0142]
Examples of suitable hair conditioners nonexclusively include quatemized compounds such as behenamidopropyl PG-dimonium chloride, tricetylammonium chloride, dihydrogenated tallowamidoethyl hydroxyethylmonium methosuifate, and mixdures thereof as well as lipophilic compounds like cetyl alohol, stearyl alcohol, hydrogenated polydecene, and mixtures thereof. [0143]
An example of a suitable hair softener nonexclusively includes silicone compounds, such as those that are either non-volatile or volatile and those that are water soluble or water insoluble. Examples of suitable silicones include organo-substituted polysiloxanes, which are either linear or cyclic polymers of monomeric silicone/oxygen monomers and which nonexcusively include cetyl dimethicone; cetyl triethylammonium dimethicone copolyol phthalate; cyclomethicone; dimethicone copolyol; dimethicone copolyol lactate; hydrolyzed soy protein/dimethicone copolyol acetate; silicone quatemium 13; stearalkonium dimethicone copolyol phthalate; stearamidopropyl dimethicone; and mixtures thereof. [0144]
Examples of suitable hair moisturizers nonexclusively include panthenyl ethyl ether, phytantriol, and mixtures thereof. [0145]
Examples of sunscreen agents nonexclusively include butyi methoxydibenzoylmethane, octyl methoxycinnamate, oxybenzone, octocrylene, octyl salicylate, phenylbenzimidazole sulfonic acid, ethyl hydroxypropyl aminobenzoate, menthyl anthranilate, aminobenzoic acid, cinoxate, diethanolamine methoxycinnamate, glyceryl aminobenzoate, titanium dioxdde, zinc o)xde, oxybenzone, padimate o, red petrolatum, and mixtures thereof. [0146]
An example of a suitable tanning agent nonexclusively includes dihydroxyacetone. [0147]
Examples of skin lightening agents nonexlusively include hydroquinone, catechol and its derivativs, ascorbic acid and Ks derivatives, and mixtures thereof. [0148]
Examples of suitable insecticides (including insect repellents, antiscabies and antlice treatments) nonexcusively include pennethrin, pyrethrin , piperonyl butoxdde, imidacloprid, N,N-diethyl toluamide, which refers to the material containing predominantly the meta isomer, i.e., N,N-diethyl-mtoluamide, which is also known as DEET; compounds of the formula iX [0149]
wherein [0150]
R[0151] ₅is a branched or unbranched alkyl group having about 1 to about 6 carbon atoms;
R[0152] ₄is H, methyl or ethyl;
R[0153] ₇is a branched or unbranched alkyl or alkoxy group having from about I to about 8 carbon atoms; and
K is a —CN or a —COOR[0154] ₈group, wherein
R[0155] ₈is a branched or unbranched alkyl group having from about 1 to about 6 carbon atoms,
natural or synthetic pyrethroids, whereby the natural pyrethroids are contained in pyrethrum, the etract of the ground flowers of Chrysanthemum cinerariaefolium or C coccineum; and mixtures thereof. Within the structure of Formula K(. are ethyl 3-(N-butylacetamido)propionate, wherein R[0156] ₇is a CH₃group, R₅is an n-butyl group, R₈is H, K is COOR₈and R₈is ethyl, which is avalable commercially from Merck KGaA of Darmstadt, Germany under the name, “Insect Repellent 3535.”
An example of an anti fungal for foot preparations nonexlusively includes tolnaftate. [0157]
Examples of suitable depilating agents nonexclusively include calcium thioglycolate, magnesium thioglycolate, potassium thioglycolate, strontium thioglycolate, and mixtures thereof. [0158]
Examples of suitable exdemal analgesics and local anesthetics nonexcusively include benzocaine, dibucaine, benzyl alcohol, camphor, capsaicin, capsicum, capsicum oleoresin, juniper tar, menthol, methyl nicotinate, methyl salicylate, phenol, resorcinol, turpentine oil, and mixtures thereof. [0159]
Examples of suitable antiperspirants and deodorants nonexclusively include aluminium chlorohydrates, aluminium zirconium chlorohydrates, and mixtures thereof. [0160]
Examples of suitable counterirritants nonexlusively include camphor, menthol, methyl salicate, peppermint and clove oils, ichtammol, and mixtures thereof. [0161]
An example of a suitable inflammation inhibitor nonexclusively includes hydrocortisone. [0162]
Examples of suitable hemorrhoidal products nonexlusively include the anesthetics such as benzocaine, pramo)dne hydrochloride, and mixtures thereof; antiseptics such as benzethonium chloride; astringents such as zinc oxide, bismuth subgallate, balsam Peru, and mixtures thereof; skin protectants such as cod liver oil, vegetable oil, and mixtures thereof. [0163]
Examples of suitable make-up preparations nonexciusively include components for lipstkk, rouge, blush, eye liner, eyeshadow powder, mascara, face powder, and mixtures thereof. [0164]
One preferred type of benefit agent includes those therapeutic components that are effective in the treatment of dandruff, seborrheic dermnatitis, and psoriasis as well as the symptoms associated therewith. Examples of such suitable benefits agents nonexcusively include zinc pyrithione, shale oil and derivatives thereof such as sulfonated shale oil, selenium sulfide, sulfur, salicylic acid; coal tar; povidone-iodine, imidazoles such as ketoconazole, dichlorophenyl imidazolodioxalan, which is commercially available from Janssen Phannaceutica, N.V., under the tradename, “Elubiol”, clotrimazole, Itraconazole, miconazole, clirnbazole, tioconazole, sulconazole, butoconazole, fluconazole, miconazolenitrile and any possibl stereo isomers and derivatives thereof such as anthralin; piroctone ofamine (Octopiroo; selenium sulfide; ciclopiroxolamine; antipsoriasis agents such as vitamin D analogs, e.g. calcipotriol, calcitriol, and tacaleitrol; vitamin A analogs such as esters of vitamin A, e.g. vitamin A palmitate, retinoids, retinols, and retinoic acid; corticosteroids such as hydrocortisone, clobetasone, butyrate, clobetasol propionate and mixtures thereof. [0165]
Most preferred benefit agents nonexclusively include sulfonated shale oil, elubiol, 6-(1-piperidinyl) -2,4pyrimidinediamine-3-oxide, finasteride, ketoconazole, salicylic acid, zinc pyrithione, coal tar, benzoyl peroxdde, selenium sulfide, hydrocortisone, sulfur, menthol, pramo)dne hydrochloride, tricetylammonium chloride, polyquatemium 10, panthenol, panthenol triacetate, vitamin A and derivatives thereof, Wamin B and derivatives thereof, vitamin C and derivatives thereof, vitamin D and derivatives thereof, vitamin E and derivatives thereof, vitamin K and derivatives thereof, keratin, lysine, arginine, hydrolyzed wheat proteins, hydrolyzed silk proteins, octyl methoxycinnamate, oxybenzone, minoxidil, titanium dio)xde, zinc dio)de, retinol, erthromycin, tretinoin, and mixtures thereof. [0166]
The amount of benefit agent to be combined with the cleansing composition or the delivery system may vary depending upon, for example, the resulting benefit desired and the sensiivi of the user to the benefit agent. Unless otherwise expressed herein, preferably the benefit agent is present in the cleansing composition or delivery system in an amount, based upon the total weight of the composition or delivery system, from about 0.001 percent to about 20 percent, and preferably from about 0.001 percent to about 10 percent, and more preferably from about 0.001 percent to about 5 percent. [0167]
Another embodiment of the present invention is directed to a method for enhancing the deposition of benefit agents which comprises topically administering to a desired location on a human or animal the delivery system composition as described above combined with an effective amount of a benefit agent and an optional detergent. While the frequency and amount of the delivery system to be applied will depend upon, for example, the type and amount of benefit agent available, the intended usage of the final composition, i.e. therapeutic versus maintenance regimen, the amount and type of detergent present, and the sensitivity of the individual user to the delivery system, typically the delivery system of the present invention should be topically applied to affected body parts at regular intervals, and preferably from about 2 to about 14 times per week. More preferably, the delivery system composition is applied more frequently during the initial stages of treatment, e.g. from about 5 to about 7 times per week until the desired effect is achieved, then less frequently when maintenance is desired, e.g. from about 2 to about 5 times per week. [0168]
In a preferred embodiment wherein the delivery system composition containing a benefit agent is incorporated into a shampoo, the shampoo is applied to wet hair, then the hair is washed in accortance with known practices. More preferably, the composition remains on the hair for greater than about 0 to about 10 minutes, and preferably from about 1 to about 5 minutes before rinsing. [0169]
An altemative preferred embodiment of the present invention is directed to a method for treating hair loss, such as hair loss resulting from alopecia, comprising topically applying the above-described delivery system composition, the hair loss benefit agent, and the optional detergent, to a desired location on an animal or human, wherein the benefit agent is comprised of an effective amount of a hair loss treatment agent such as minoxdil or mbdure thereof. As used herein, “hair loss treatment agents” shall include agents capable of growing hair and/or agents capable of preventing the loss of hair. By “effective amount,”it is meant an amount effective for treating hair loss and preferably may range from, based upon the total weight of the cleansing composition/delivery system, from about 0.001 percent to about 20 percent, and preferably from about 1 percent to about 5 percent. [0170]
Examples of benefit agents suitable for treating hair loss include, but are not limited to potassium channel openers or peripheral vasodilators such as mino)ddil, diazoxide, and compounds such as N*-cyano-N-(tert-pentyl)-N′-3-pyridinyl-guanidine (“P-1 075”) as disclosed in U.S. Pat. No. 5,244,664, which is incorporated herein by reference; vitamins, such as vitamin E and vitamin C, and derivatives thereof such as vitamin E acetate and vtamin C palmiate; hormones, such as erythropoietin, prostaglandins, such as prostaglandin El and prostaglandin F2-alpha; fatty acids, such as oleic acid; diruretics such as spironolactone; heat shock proteins (HSP), such as HSP 27 and HSP 72; calcium channel blockers, such as verapamil HCL, nifedipine, and diltiazemamiloride; immunosuppressant drugs, such as cyclosporin and Fk-506; 5 alpha-reductase inhibitors such as finasteride; growth factors such as, EGF, IGF and FGF; transforming growth factor beta; tumor necrosis factor; non-steroidal anti-inflammatory agents such as benoxaprofen; retinoids such as tretinoin; cytokines, such as IL, IL-1 alpha, and IL-1 beta; cell adhesion molecules such as ICAM; glucorcorticoids such as betametasone; botanical exracts such as aloe, clove, ginseng, rehmannia, swertia, sweet orange, zanthoxyum, Serenoa repens (saw palmetto), Hypoxis rooperi, stinging nettle, pumpkin seeds, and rye pollen; other botanical extracts including sandlewood, red beet root, chrysanthemum, rosemary, burdock root and other hair growth promoter activators which are disclosed in DE 4330597 which is incorporated by reference in its entirety herein; homeopathic agents such as Kalium Phosphoricum D2, Azadirachta indica D2, and Joborandi Dl; genes for cytokines, growth factors, and male-pattered baldness; antifungals such as ketoconazole and elubiol; antibiotics such as streptomycin; proteins inhibitors such as cycloheximide; acetazolamide; benoxaprofen; cortisone; diltiazem; hexachlorobenzene; hydantoin; nifedipine; penicillamine; phenothaiazines; pacidil; psoralens, verapamil; zidovudine; alphaglucosylated rutin having at least one of the following rutins: quercetin, isoquercitrin, hespeddin, naringin, and methyihesperidin, and flavonoids and transglycosidated derivatives thereof which are all disclosed in JP 7002677, which is incorporated by reference in is entirety herein; and mixtures thereof. [0171]
Preferred hair loss treatment agents include 6-0-piperdinyl)-2,4-pymidinediamine-3-oxdde, N′-cyano-N-(tert-pentyl)-N′-3-pyridinyl-guanidine, finasterde, retinoids and dernatives thereof, ketoconazole, elubiol or mixtures thereof. [0172]
Another embodiment of the present invention is directed to a method for inhibiting hair growth comprising topically applying the abovedescribed delivery system composition combined with a benefit agent and an optional detergent, to a desired area on an animal or human for inhibiting hair growth, wherein the benefit agent is comprised of an effective amount of a hair growth inhibiting agent. In a preferred embodiment, the delivery system composition contains, based upon the total weight of the composition, from about 0.001 percent to about 20 percent, and preferably from about 0.01 percent to about 5 percent hair growth inhibiting agent. [0173]
Examples of benefit agents suitable for use in inhibiting hair growth include: serine protesses such as trypsin; vitamins such as alpha-tocophenol (vitamin E) and deriaties thereof such as tocophenol acetate and tocophenol palmitate; antineoplastic agents, such as doxorubicin, cyclophosphamide, chlormethine, methotrexate, fluorouracil, vincristine, daunorubicin, bleomycin and hydroxycarbamide; anticoagulants, such as heparin, heparinoids, coumaerins, detran and indandiones; antithyroid drugs, such as iodine, thiouracils and carbimazole; lithium and lithium carbonate; interferons, such as interferon alpha, interferon alpha-2a and interferon alpha-2b; retinoids, such as retinol (vitamin A), isotretinoin: glucocorticoids such as betamethasone, and dexamethosone; antihyperlipidaemic drugs, such as triparanol and clofibrate; thallium; mercury; albendazole; allopurinol; amiodarone; amphetamines; androgens; bromocriptine; butyrophenones; carbamazepine; cholestyramine; cimetidine; clofibrate; danazol; desipramine; dbirazine; ethambutol; etionamide; fluoxetine; gentamicin, gold salts; hydantoins; ibuprofen; impramine; immunoglobulins; indandiones; indomethacin; intraconazole; levadopa; maprotiline; methysergide; metoprolol; metyrapone; nadolol; nicotinic acid; potassium thiocyanate; propranolol; pyridostimine; salicylates; sulfasalazine; terfenadine; thiamphenicol; thiouracils; trimethadione; troparanol; valproic acid; and mixtures thereof. [0174]
Preferred hair growth inhibitory agents include serene proteases, retinol, isotretinoin, betamethoisone, alpha-tocophenol and derivatives thereof, or mixtures thereof. [0175]
Another preferred embodiment of the present invention is directed to a method for treating acne and for reducing the signs of aging, i.e. wrinkles, fine lines, and other manifestations of photodamage, comprising topically applying the above-described delivery system composition, the relevant benefit agent, and the optional detergent to the skin of an animal or human at a desired area, wherein the beneft agent is comprised of an effective amount of an antiacne agent or an anti-aging agent, respectively. [0176]
Eamples of suitable anti-aging agents include, but are not limited to inorganic sunscreens such as titanium dio)xde and zinc o)xde; organic sunscreens such as octyl-methyl cinnamates and derivatives thereof; retinoids; vitamins such as vitamin E, vitamin A, vitamin C, vitamin B, and derivativs thereof such as vitamin E acetate, vitamin C palmitate, and the like; antoxidants including beta carotene, alpha hydroxy acid such as glycolic acid, citric acid, lactic acid, malic acid, mandelic acid, ascorbic acid, alpha-hydroxybutyric acid, alpha-hydroxbutyric acid, alpha-hydroxyisocaproic acid, atrrolactic acid, alpha-hydrox valeric acid, ethyl pyruvate, galacturonic acid, glucopehtonic acid, glucopheptono 1 ,41actone, gluconic acid, gluconolactone, glucuronic acid, glucurronolactone, glycolic acid, isopropyl pyruvte, methyl pyruvate, mucic acid, pyruvia acid, saccharic acid, saccaric acid 1 ,4lactone, tartaric acid, and tartronic acid; beta hydroxy acids such as beta-hydroxybutyric acid, beta-phenyl-lactic acid, beta-phenylpyru%ic acid; botanical exracts such as green tea, soy, milk thistle, algae, aloe, angelica, bitter orange, coffee, goldthread, grapefruit, hoellen, honeysuckle, Job's tears, lithospermum, mulberry, peony, puerarua, nice, safflower, and mixtures thereof. [0177]
Preferred anti-aging agents include retinoids, anti-oxddants, alpha-hydroxy acids and beta-hydroxy acid with retinol and tretinoin being most preferred. [0178]
Suitable amounts of anti-aging agents indude, based upon the total weight of the delivery system composition and optional detergent, from about 0.01 percent to about 10 percent, and preferably from about 0.04 percent to about 5 percent. [0179]
Examples of suitable anti-acne agents include, but are not limited to topical retinoids (tretinoin, isotretinoin, motretinide, adapalene, tazarotene, azelaic acid, retinol); salicyli acid; benzoyl peroxdde; resorcinol; antibiotics such as tetracycline and isomers thereof, erythromycin, and the anti-inflammatory aagents such as ibuprofen, naproxen, hetprofen; botanical exracts such as alnus, amica, artemisia capillaris, asiasarum root, birth, calendula, chamomile, cnidium, comfrey, fennel, galla rhois, hawthrom, houftuynia, hypericum, jujube, kiwi, licorice, magnolia, olive, peppermint, philodendron, salvia, sasa albo- marginata; imidazoles such as ketoconazole and elubiol, and those described in Gollnick, H et al. 196(l) Dermatology Sebaceous Glands, Acne and Related Disorders, 119-157 (1998), which is incorporated by reference herein, and mixtures thereof. [0180]
Preferred anti-acne agents include benzoyl pero)dde, retinol, elubiol, antibiotics, and salicylic acid, with retinol and tretinoin being most preferred. [0181]
Suitable amount of anti-acne agents include, based upon the total weight of the delivery system composition and optional detergent, from about 0.01 percent to about 10 percent, and preferably from about 0.04 percent to about 5 percent. [0182]
Another preferred embodiment of the present invention is directed to a method for depigmenting the skin comprising topically applying to skin at a desired area the above-described delivery system composition, the optional detergent, and an effective amount of the depigmentation benefit agent. Suitable effective amounts of depigmentation agents include, based upon the total weight of the delivery system, from about 0.01 percent to about 10 percent, and preferably from about 0.04 percent to about 5 percent. [0183]
Examples of suitable depigmentation agents include, but are not limited to retinoids such as retinol; Kojic acid and its derivatives such as, for example, kojic dipalmitate; hydroquinone and it derivatives such as arbutin; transexamic acid; vitamins such as niacin, vitamin C and its derivatives; azelaic acid; placertia; licorice; eAracts such as chamomile and green tea, and mixtures thereof, with retinol, Kojic acid, and hydroquinone, being preferred. [0184]
An altemative preferred embodiment of the present invention is directed to a method for treating the symptoms and/or the diseases of dandruff, sebontheic dermatitis and/or psorasis, comprisn topically applying the above-described delivery system composition, the benefit agent, and the optional detergent, to a location desired wherein the benefit agent is comprised of an effective amount of a dandruff treatment agent, a seborheic dermatitis treatment agent, or a psoriasis treatment agent, respectively. As used herein, “dandruff treatment agent,” “sebonheic dermatitis treatment agent,” or a “psoriasis treatment agent,” respectively, shall include agents capable of treating the symptoms and/or the diseases of dandruff, seborrheic dermatitis, and psoriasis, respectively. By “effective amount”, it is meant an amount effective for treating the disease and/or the symptoms associated therewith and preferably may range from, based upon the total weight of the vesicle delivery system and optional detergent, from about 0.001 percent to about 10 percent, and preferably from about 0.01 percent to about 5 percent. [0185]
Examples of benefit agents suitable for treating the symptoms and/or the diseases of dandruff, seborrheic dermatitis and/or psoriasis, respectively, nonexlusively include those set forth above with shale oil and derivatives thereof, elubiol, ketoconazole, coal tar, salicylic acid, zinc pyrithione, selenium sulfide, hydrocortisone, sulfur, menthol, pramoxine hydrochloride, and mixtures thereof being particularly preferred. [0186]
We have unexpectedly found that the above-described cleansing composition/ delivery system is capable of efficiently mediating the deposition and permeation of various benefit agents, such as antidandruff agents, onto and into the skin following topical administration thereto. [0187]
We have surprisingly found that the cleansing composition of the present invention is suffcienfly stable to resist phase separation even though both an anionic surfactant and cationic components may be present in the composition. Furthermore, the cleansing composition not only effectively cleanses the hair due to the ability to include an anionic surfactant therein, but it also effectively deposits conditioning agents on the hair without exhibiting an excessive build-up thereon, even after repeated shampooing. Consequently, the hair is left in a more manageable, softer, shiny and overall more esthetically pleasing state after only a single application of the composition to the hair. [0188]
We have further unexpectedly found that the above-described delivery system is capable of effiently mediating the deposition and permeation of various benefit agents, such as antidandruff agents, onto and into the skin, hair, and nails, following topical administration thereto. [0189]
The invntion illust1Uvly disclosed herein suitably may be practiced h the absence of any conent, nedient, or step which is not specdically disclosed herein. Sevral examples are set forth below to further illustrated the nature of the invntion and the manner of canying it out However, the invention should not be considered as being limited to the details thereof. [0190]

EXAMPLES

Example 1

Presaration of Cleansing Shampoo containing Two Cationic Agents

Shampoos comprised of the following components as set forth in Table 1 were prepared:

TABLE 1


Cleansing shampoo with two cationic depositing enhancing agents.

	Trade Name	CTFA	% wt/wt	Supplier

1	DI Water	DI Water	72.965
2	Salcare SC 60	Acrylamidopropylltrimoniumchloride	0.08	Ciba Specialties
		Acrylamide Copolymer
3	Jaguar C 17	Guar Hydroxypropyl Trimonium	0.15	Rhone-Poulenc
		Chloride
4	Citric Acid Anh	Citric Acid	0.025	Roche
5	Elubiol	Dichlorophenyl Imidazoldioxolan	0.50	Janssen Pharm.
6	Salicylic Acid	Salicylic Acid	1.00	Rhone-Poulenc
7	Cutina AGS	Glycol Distearate	1.75	Henkel
8	Methyl Paraben	Methyl Paraben	0.20	Nipa Hardwicke Inc.
9	Empicol EAC 70	Ammonium Laureth Sulfate	3.6	Albright & Wilson
10	Empicol AL 70	Ammonium Lauryl Sulfate	11.8	Albright & Wilson
11	Tego Betaine E	Cocamidopropyl Betaine	2.43	Goldschmidt
12	Tego Betaine F 50	Cocamidopropyl Betaine	3.00	Goldschmidt
13	Polyox WSR-205	PEG 14M	0.05	Amerchol
14	Ninol LMP	Lauramide MEA	1.00	Stephan
15	DL-Panthenol-50%	Panthenol	0.15	Roche
16	Phytantriol	Phytantriol	0.025	Roche
17	Hydrotriticum WAA	Wheat Amino Acid	0.22	Croda
18	Sodium Benzoate	Sodium Benzoate	0.20	EM Industries
19	Versene 100XL	Tetrasodium EDTA	0.20	Dow Chemical
20	BHT	Butylated Hydroxytoluene	0.10	EM Industries
21	Lorena	Fragrance	0.50	Creation Aromatiques
22	Glycacil L	Iodopropynyl butylcarbamate	0.05	Lonza
23	NaOH (25%)	Sodium Hydroxide	QS	Mallinckrodt
	Total		100.00

Shampoo Process: [0192]
A vessei was charged with % amount of deionized water (component 1). Components 2, 3 and 4 were 5 added sequentially thereto, both with ten minute intervals between the additions and with mixng at 500 rpm under constant conditions. The resulting mixdure was then heated to about 63 to 67° C. with mixing at 500 rpm. Component 5 was then to the mbdure. After all the elubiol had dissolved, salicylic acid (component 6) was added thereto with mixing for 15-20 minutes at constant conditions. The resultant mbdure was then heated to 70-75° C. and components 7, 8, 9 and 10 were sequentially added under mixing. Component 9 through 13 were sequentially added thereto with mixing under constant conditions. The resultant primary mbdure was then cooled to 50° C. [0193]
[0194] Components 15, 16, 20 and 21 were combined in a separate beaker at 25-30° C. to form a prembdure. After cooling the primary mbdure to 50° C., component 14, component 17, the prembdure, component 18, component 19 and component 22 were sequentially added thereto with mixing. Sodium hydroxdde was added thereto with mixing to adjust the pH to about 5.3-5.7. The mbdure was then continuously mbed and cooled to about 25-30° C. The remaining amount of deionized water was added to the final volume and was mbied at 500 rpm until uniform.

Example 2

Preparation of Cleansina Shamtoo containing Three Cationic Agents

Shampoos comprised of the following components as set forth in Table 2 were prepared:

TABLE 2


Cleansing shampoo with three cationic deposition enhancing agents.

	Trade Name	CTFA	% wt/wt	Supplier

1	DI Water	DI Water	72.665
2	Salcare SC 60	Acrylamidopropylltrimoniumchloride	0.08	Ciba Specialty
		Acrylamide Copolymer
3	Jaguar C 17	Guar Hydroxypropyl Trinionium	0.15	Rhone-Poulenc
		Chloride
4	Citric Acid Anh	Citric Acid	0.025	Roche
5	Cutina AGS	Glycol Distearate	1.75	Henkel Corporation
6	Methyl Paraben	Methyl Paraben	0.20	Nipa Hardwicke Inc.
7	Merquat 2001	Polyquatemium 47	0.30	Calgon
8	Empicol EAC 70	Ammonium Laureth Sulfate	3.6	Albright & Wilson
9	Empicol AL 70	Ammonium Lauryl Sulfate	11.8	Albright & Wilson
10	Tego Betaine E	Cocamidopropyl Betaine	2.43	Goldschmidt
11	Tego Betaine F 50	Cocamidopropyl Betaine	3.00	Goldschmidt
12	Elubiol	Dicholorohenyl Imidazoldioxolan	0.50	Janssen Pharm.
13	Salicylic Acid	Salicylic Acid	1.00	Rhone-Poulenc
14	Polyox WSR-205	PEG 14M	0.05	Amerchol
15	Ninol LMP	Lauramide MEA	1.00	Stepan
16	DL-Panthenol-50%	Panthenol	0.15	Roche
17	Phytantriol	Phytantriol	0.025	Roche
18	Hydrotriticum WAA	Wheat Amino Acid	0.22	Croda
19	Sodium Benzoate	Sodium Benzoate	0.20	EM Industries
20	Versene 100XL	Tetrasodium EDTA	0.20	Dow Chemical
21	BHT	Butylated Hydroxytoluene	0.10	EM Industries
22	Lorena	Fragrance	0.50	Creation Aromatiques
23	Glycacil L	Iodopropynyl butylcarbamate	0.05	Lonza
24	NaOH (25%)	Sodium Hydroxide	QS	Mallinckrodt
			100.00

Shampoo Process: [0196]
A vessel was charged with % amount of deionized water (component 1). Components 2, 3 and 4 were added sequentially, with ten minute intervals between the additions and with mixing at 500 rpm under constant conditions. The resulting mbdure was then heated to about 70 to 75° C. with mbing at 500 rpm. Component 5 and 6 were added and mid at 500 rpm until dispersed for about 15 to 25 minutes. At 70 to 75° C., components 9 through 11 were added with mixdng. [0197]
After cooling the resultant mixdure to about 63 to 67° C., elubiol, salicylic acid (component 6) and component 14 were added sequentially thereto with mixdng until the latter three components were completely dispersed. The resultant primary mbdure was then cooled to 50° C. [0198]
[0199] Components 15, 16, 20 and 21 were combined in a separate beaker at 25-30° C. to fbrm a prembdure. After cooling the primary mbdure to 50° C., components 15 and 18 were added thereto. The prembdure followed by components 19, 20 and 23 were then added thereto sequentially with mixing. Sodium hydroxide was then added thereto with mixing to adjust the pH to about 5.3-5.7. The mbdure was continuously mied and cooled to about 25-30° C. The remaining amount of deionized water was added to the final volume and was mbed at 500 rpm until uniform.

Example 3

Preparation of Cleansing Shampoo contain in Two Cationic Agents and One Silicone Quaternary Compound.

Shampoos comprised of the following components as set forth in Table 3 were prepared:

TABLE 3


Cleansing shampoo with two cationic deposition enhancing agents and a silicone
compound.

	Trade Name	CTFA	% wt/wt	Supplier

1	DI Water	DI Water	72.765
2	Salcare SC 60	Acrylamidopropylltrimoniumchloride	0.08	Ciba Industries
		Acrylamide Copolymer
3	Jaguar C 17	Guar Hydroxypropyl Trimonium	0.15	Rhone-Poulenc
		Chloride
4	Citric Acid Anh	Citric Acid	0.025
5	Cutina AGS	Glycol Distearate	1.75	Henkel Corporation
6	Methyl Paraben	Methyl Paraben	0.20	Nipa Hardwicke Inc
7	Empicol EAC 70	Ammonium Laureth Sulfate	3.6	Albright & Wilson
8	Empicol AL 70	Ammonium Lauryl Sulfate	11.8	Albright & Wilson
9	Tego Betaine E	Cocamidopropyl Betaine	2.43	Goldschmidt
10	Tego Betaine F 50	Cocamidopropyl Betaine	3.00	Goldschmidt
11	Elubiol	Dicholorohenyl Imidazoldioxolan	0.50	Janssen Pharm.
12	Salicylic Acid	Salicylic Acid	1.00	Rhone-Poulenc
13	Polyox WSR-205	PEG 14M	0.05	Amerchol
14	Ninol LMP	Lauramide MEA	1.00	Stepan
15	DL-Panthenol-50%	Panthenol	0.15	Roche
16	Phytantriol	Phytantriol	0.025	Roche
17	Biosil Basics SPQ	Silicone Quatemium-13	0.20	Biosil
18	Hydrotriticum WAA	Wheat Amino Acid	0.22	Croda
19	Sodium Benzoate	Sodium Benzoate	0.20	EM Industries
20	Versene 100XL	Tetrasodium EDTA	0.20	Dow Chemical
21	BHT	Butylated Hydroxytoluene	0.10	EM Industries
22	Lorena	Fragrance	0.50	Creation Aromatiques
23	Glycacil L	Iodopropynyl butylcarbamate	0.05	Lonza
24	NaOH (25%)	Sodium Hydroxide	QS	Mallinckrodt
			100.00

Shampoo Process: [0201]
A vessel was charged with % amount of deionized water (component 1). Components 2, 3 and 4 were added sequentially, with ten minute intervals between the additions and with mixing at 500 rpm under constant conditions. The resulting mbdure was then heated to about 70 to 75° C. wih mbing at 500 rpm. Component 5 and 6 were added and mbed at 500 rpm until dispersed for about 15 to 25 minutes. At 70 to 75° C., components 7 through 11 were added with mixing. [0202]
After cooling the resultant mbdure to about 63 to 67° C., elubiol, salicylic acid (component 6) and component 14 were added sequentially thereto with mixing until the latter three components were completely dispersed. The resultant primary mbdure was then cooled to 50° C. [0203]
[0204] Components 15, 16, 21 and 22 were combined in a separate beaker at 25-30° C. to form a prembdure. After cooling the primary miture to 50° C., components 14, 17 and 18 were added. The prembdure followed by components 19, 20 and 23 were added thereto sequentially with Mdng. Sodium hydro)dde was added thereto with mixing to adjust the pH to about 5.3-5.7. The mbdure was continuously mbed and cooled to about 25-30° C. The remaining amount of deionized water was added to the inal vwnfume and was mbed at 500 rpm until uniform.

Example 4

Preparation of Cleansing Shamgoo containing Three Cationic Additives and Two Silicone Quaternary Compounds.

Shampoos comprised of the following components as set forth in Table 4 were prepared:

TABLE 4


Cleansing shampoo with three cationic deposition enhancing agents and two silicone
compounds.

	Trade Name	CTFA	% wt/wt	Supplier

1	DI Water	DI Water	72.32
2	Salcare SC 60	Acrylamidopropylltrimoniumchloride	0.08	Ciba Specialty
		Acrylamide Copolymer
3	Jaguar C 17	Guar Hydroxypropyl Trimonium	0.15	Rhone-Poulenc
		Chloride
4	Citric Acid Anh	Citric Acid	0.025
5	Cutina AGS	Glycol Distearate	1.75	Henkel
				Corporation
6	Methyl Paraben	Methyl Paraben	0.20	Nipa Hardwicke
				Inc.
7	Merquat 2001	Polyquatemium 47	0.30	Calgon
8	Empicol EAC 70	Ammonium Laureth Sulfate	3.60	Albright & Wilson
9	Empicol AL 70	Ammonium Lauryl Sulfate	11.8	Albright & Wilson
10	Tego Betaine E	Cocamidopropyl Betaine	2.43	Goldschmidt
11	Tego Betaine F 50	Cocamidopropyl Betaine	3.00	Goldschmidt
12	Elubiol	Dicholorohenyl Imidazoldioxolan	0.50	Janssen Pharm.
13	Salicylic Acid	Salicylic Acid	1.00	Rhone-Poulenc
14	Polyox WSR-205	PEG 14M	0.05	Amerchol
15	Ninol LMP	Lauramide MEA	1.00	Stepan
16	Biosil Basics SPQ	Silicone Quatemium-13	0.20	Biosil
				Technologies Inc.
17	Biosil Basics	Cetyl Triethylmonium-Dimethicone	0.15	Biosil
	Cetylsil	Copolyol Phthalate		Technologies Inc.
18	DL-Panthenol-50%	Panthenol	0.15	Roche
19	Phytantriol	Phytantriol	0.025	Roche
20	Hydrotriticum WAA	Wheat Amino Acid	0.22	Croda
21	Sodium Benzoate	Sodium Benzoate	0.20	EM Industries
22	Versene 100XL	Tetrasodium EDTA	0.20	Dow Chemical
23	BHT	Butytated Hydroxytoluene	0.10	EM Industries
24	Lorena	Fragrance	0.50	Creation Aromatiques
25	Glycacil L	Iodopropynyl butylcarbamate	0.05	Lonza
26	NaOH (25%)	Sodium Hydroxide	QS	Mallinckrodt
			100.00

Shampoo Process: [0206]
A vessel was charged with % amount of deionized water (component 1). Components 2, 3 and 4 were added sequentially, with ten minute intervals between the additions and with mixng at 500 rpm under constant conditions. The resulting mbdure was then heated to about 70 to 75° C. with mixing at 500 rpm. Component 5 and 6 were added thereto and mbed at 500 rpm until dispersed, i.e., for about 15 to 25 minutes. At 70 to 75° C., components 7 through 11 were added thereto with mixing. [0207]
After cooling the resultant mbdure to about 63 to 67° C., elubiol, salicylic acid (component 13) and component 14 were added sequentially thereto with mixing until the latter tMme components were completely dispersed therein. The resultant primary mbdure was then cooled to 50° C. [0208]
Components 18, 19, 23 and 24 were combined in a separate beaker at 25-30° C. to form a prembdure. After cooling the primary mbdure to 50° C., [0209] components 15, 16, 17 and 20 were added thereto. The prembdure followed by components 21, 22 and 25 added thereto sequentially with mixing. Sodium hydroxide was then added thereto with mixing to adjust the pH to about 5.3-5. The mbdure was continuously mbied and cooled to about 25-30° C. The remaining amount of deionized water was added to the final volume and was mbed at 500 rpm until uniform.

Example 5

Preparation of Cleansing Shampoo containing Three Cationic Additives and One Silicone Quatemary Compounds.

Shampoos comprised of the following components as set forth in Table 5 were prepared:

TABLE 5


Cleansing shampoo with three cationic deposition enhancing agents and one silicon
compound.

	Trade Name	CTFA	% wt/wt	Supplier

1	DI Water	DI Water	72.82
2	Salcare SC 60	Acrylamidopropylltrimoniumchloride	0.08	Ciba Specialties
		Acrylamide Copolymer
3	Jaguar C17	Guar Hydroxypropyl Trimonium	0.15	Rhone-Poulenc
		Chloride
4	Citric Acid Anh	Citric Acid	0.025	Roche
5	Cutina AGS	Glycol Distearate	1.75	Henkel Corporation
6	Methyl Paraben	Methyl Paraben	0.20	Nipa Hardwicke Inc.
7	Empicol EAC 70	Ammonium Laureth Sulfate	3.8	Albright & Wilson
8	Empicol AL 70	Ammonium Lauryl Sulfate	11.8	Albright & Wilson
9	Tego Betaine E	Cocamidopropyl Betaine	2.43	Goldschmidt
10	Tego Betaine F	Cocamidopropyl Betaine	3.00	Goldschmidt
	50
11	Elubiol	Dichlorophenyl	0.500	Janssen Pharm.
		Imidazoldioxolan
12	Salicylic Acid	Salicylic Acid	1.000	Rhone-Poulenc
13	Polyox WSR-205	PEG 14M	0.05	Amerchol
14	Ninol LMP	Lauramide MEA	1.00	Stepan
15	Biosil Basics	Cetyl Triethylmonium-	0.15	Biosil Technologies
	Cetylsil	Dimethicone Copolyol Phthalate		Inc.
16	Hydrotriticum	Wheat Amino Acid	0.220	Croda
	WAA
17	DL-Panthenol-	Panthenol	0.15	Roche
	50%
18	Phytantriol	Phytantriol	0.025	Roche
19	Sodium Benzoate	Sodium Benzoate	0.20	EM Industries
20	Versene 100XL	Tetrasodium EDTA	0.20	Dow Chemical
21	BHT	Butylated Hydroxytoluene	0.10	EM Industries
22	Lorena	Fragrance	0.50	Creation Aromatiques
23	Glycacil L	Iodopropynyl butylcarbamate	0.05	Lonza
24	Citric Acid	Citric Acid (50%)	QS	Mallinckrodt
	Total		100.00

Shampoo Process: [0211]
A vessel was charged with % amount of deionized water (component 1). Components 2, 3 and 4 were added sequentially, with ten minute intervals between the additions and with mixing at 500 rpm under constant conditions. The resulting mixdure was then heated to 70 to 75° C. with mixdng at 500 rpm. Components 5 and 6 were then to the mixdure with mixing for about 15 to 25 minutes. The resultant mbdure was maintained at 70-75° C., and components 7 through 10 were sequentially added thereto with mixing. After the resultant mbdure was cooled to about 63-67° C., elubiol (component 11) was added thereto with mbixng under constant conditions. Salicylic acid was then added thereto followed by component 13 under constant mixing to form a primary mbdure. [0212]
[0213] Components 15, 16, 21 and 22 were combined in a separate beaker at 25-30° C. to form a prembdure. After cooling the primary mbdure to 50° C., components 14, 17, and 18 were sequentially added thereto with mixing. The prembdure was then added thereto. Sodium hydro)xde was then added thereto with mixing to adjust the pH to about 5.35.7. The mbdure was continuously mbied and cooled to about 25-30° C. The remaining amount of deionized water was added to the final volume and was mbed at 500 rpm until uniform.

Example 6

Preparation of Cleansing Shampoo

Shampoos comprised of the following components as set forth in Table 6 were prepared:

TABLE 6


Cleansing shampoo.

	Trade Name	CTFA	% wt/wt	Supplier

1	DI Water	DI Water	73.225
2	Cutina AGS	Glycol Distearate	1.75	Henkel Corporation
3	Methyl Paraben	Methyl Paraben	0.20	Nipa Hardwicke Inc.
4	Empicol EAC 70	Ammonium Laureth Sulfate	3.60	Albright & Wilson
5	Empicol AL 70	Ammonium Lauryl Sulfate	11.80	Albright & Wilson
6	Tego Betaine E	Cocamidopropyl Betaine	2.43	Goldschmidt
7	Tego Betaine F 50	Cocamidopropyl Betaine	3.00	Goldschmidt
8	Elubiol	Dichlorophenyl Imidazoldioxolan	0.50	Janssen Pharm.
9	Salicylic Acid	Salicylic Acid	1.00	Rhone-Poulenc
10	Polyox WSR-205	PEG 14M	0.05	Amerchol
11	Ninol LMP	Lauramide MEA	1.00	Stepan
12	Hydrotriticum	Wheat Amino Acid	0.22	Croda
	WAA
13	DL-Panthenol-	Panthenol	0.15	Roche
	50%
14	Phytantriol	Phytantriol	0.025	Roche
15	Sodium Benzoate	Sodium Benzoate	0.20	EM Industries
16	Versene 100XL	Tetrasodium EDTA	0.20	Dow Chemical
17	BHT	Butylated Hydroxytoluene	0.10	EM Industries
18	Lorena	Fragrance	0.50	Creation Aromatiques
19	Glycacil L	Iodopropynyl butylcarbamate	0.05	Lonza
20	NaOH	NaOH (25%)	QS	Mallinckrodt
	Total		100.00

Shampoo Process: [0215]
A vessel was charged with % amount of deionized water (component 1) and heated to about 70 to 75° C. Components 2 and 3 were added thereto with mixing at 500 rpm under constant conditions for 15 to 20 minutes. Component 4 through 7 were added sequentially thereto with mixing under constant conditions. After the resultant mbdure was then cooled to 63-67° C., elubiol (component 11) was added thereto with mixing under constant conditions. Salicylic acid was then added thereto followed by component 10 under constant mixng to form a primary mbdure. [0216]
Components 13, 14, 17 and 18 were combined in a separate beaker at 25-30° C. to form a prembdure. After cooling the primary mbdure to 50° C., the prembdure was added thereto, then [0217] components 15, 16 and 19 were sequentially added thereto with mixing. Sodium hydro)dde was then added thereto with mixing to adjust the pH to about 5.3-5.7. The mbdure was then continuously mbed and cooled to about 25- 30° C. The remaining amount of deionized water was added to the final volume and was mbed at 500 rpm until uniform.

Example 7

Preparation of Cleansing Shampoo Containinc One Water Soluble Silicon. Compound

Shampoos comprised of the following components as set forth in Table 7 were prepared:

TABLE 7


Cleansing shampoo with one water soluble silicone deposition enhancing agent.

	Trade Name	CTFA	% wt/wt	Supplier

1	DI Water	DI Water	73.00
2	Citric Acid Anh	Citiric Acid	0.025	Roche
3	Cutina AGS	Glycol Distearate	1.75	Henkel
4	Methyl Paraben	Methyl Paraben	0.20	Mallinckrodt
5	Empicol EAC 70	Ammonium Laureth Sulfate	3.8	Albright & Wilson
6	Empicol AL 70	Ammonium Lauryl Sulfate	11.8	Albright & Wilson
7	Tego Betaine E	Cocamidopropyl Betaine	2.43	Goldschmidt
8	Tego Betaine F 50	Cocamidopropyl Betaine	3.00	Goldschmidt
9	Elubiol	Dichlorophenyl Imidazoldioxolan	0.50	Janssen Pharm.
10	Salicylic Acid	Salicylic Acid	1.00	Rhone-Poulenc
11	Polyox WSR-205	PEG 14M	0.05	Amerchol
12	Ninol LMP	Lauramide MEA	1.00	Stephan
13	DL-Panthenol-50%	Panthenol	0.15	Roche
14	Phytantriol	Phytantriol	0.025	Roche
15	Biosil Basic SPQ	Silicone Quatemium 13	0.20	Biosil
16	Hydrotriticum WAA	Wheat Amino Acid	0.22	Croda
17	Sodium Benzoate	Sodium Benzoate	0.20	EM Industries
18	Versene 100XL	Tetrasodium EDTA	0.20	Dow Chemical
19	BHT	Butylated Hydroxytoluene	0.10	EM Industries
20	Lorena	Fragrance	0.50	Creation Aromatiques
21	Glycacil L	Iodopropynyl butylcarbamate	0.05	Lonza
22	NaOH (25%)	Sodium Hydroxide	QS	Mallinckrodt
	Total		100.00

Shampoo Procss: [0219]
A vessel was charged with 3%4 amount of deionized water (component 1). Components 2 was then added thereto. The resultant mixture was then heated to 70-75oC, and components 3 & 4 were sequentially added thereto with mixing at 500 rpm under constant conditions. Component 5 through 8 were then sequentially added thereto with mixing under constant conditions. The resulting mbdure was cooled to about 63 to 67° C. with mixdng at 500 rpm. Component 9 was then added to the mbdure. After all the elubiol had dissolved therein, salicylic acid (component 10) was added thereto with mixing for 15-20 minutes at constant conditions; [0220] component 11 then was added thereto. The resultant primary mbdure was then cooled to 50° C.
Components 13, 14, 19 and 20 were combined in a separate beaker at 25-30° C. to form a prembdure. After cooling the primary miture to 50° C., component 12, [0221] component 15, component 16, the prembdure , component 17, component 18 and component 21 were sequentially added thereto wih mixing. Sodium hydroxide was added thereto with mixing to adjust the pH to about 5.3-5.7. The mbdure was continuously mbed and cooled to about 25-30° C. The remaining amount of deionized water was added to the final volume and mbied at 500 rpm until uniform.

Example 8

Preparation of Cleansing Shamooo Containing Two Water Soluble Silicone Compounds.

Shampoos comprised of the following components as set forth in Table 8 were prepared:

TABLE 8


Cleansing shampoo with two water soluble silicone deposition enhancing agents.

	Trade Name	CTFA	% wt/wt	Supplier

1	DI Water	DI Water	73.00
2	Citric Acid Anh	Citric Acid	0.025	Roche
3	Cutina AGS	Glycol Distearate	1.75	Henkel
4	Methyl Paraben	Methyl Paraben	0.20
5	Empicol EAC 70	Ammonium Laureth Sulfate	3.6	Albright & Wilson
6	Empicol AL 70	Ammonium Lauryl Sulfate	11.8	Albright & Wilson
7	Tego Betaine E	Cocamidopropyl Betaine	2.43	Goldschmidt
8	Tego Betaine F 50	Cocamidopropyl Betaine	3.00	Goldschmidt
9	Elubiol	Dichlorophenyl Imidazoldioxolan	0.50	Janssen Pharm.
10	Salicylic Acid	Salicylic Acid	1.00	Rhone-Poulenc
11	Polyox WSR-205	PEG 14M	0.05	Amerchol
12	Ninol LMP	Lauramide MEA	1.00	Stephan
13	DL-Panthenol-50%	Panthenol	0.15	Roche
14	Phytantriol	Phytantriol	0.025	Roche
15	Biosil Basic SPQ	Silicone Quatemium 13	0.20	Biosil
16	Biosil Basic Cetylsil	Cetyl Triethylammonium	0.15	Biosil
		Dimethicone Copolyol Phthalate
17	Hydrotriticum WAA	Wheat Amino Acid	0.22	Croda
18	Sodium Benzoate	Sodium Benzoate	0.20	EM Industries
19	Versene 100XL	Tetrasodium EDTA	0.20	Dow Chemical
20	BHT	Butylated Hydroxytoluene	0.10	EM Industries
21	Lorena	Fragrance	0.50	Creation Aromatiques
22	Glycacil L	Iodopropynyl butylcarbamate	0.05	Lonza
23	NaOH (25%)	Sodium Hydroxide	QS	Mallinckrodt
	Total		100.00

Shampoo Process: [0223]
A vessel was charged with % amount of deionized water (component 1). Components 2 was then added thereto. The resultant mbdure was then heated to 70-75° C. and components 3 and 4 were sequentially added thereto with mixing at 500 rpm under constant conditions. Component 5 through 8 were sequentially added thereto with mixing under constant conditions. After cooling the resulting mbiure to about 63 to 67° C. with mixing at 500 rpm, component 9 was then added to the mixture. After all the elubiol had dissolved therein, salicylic acid (component 10) was added thereto with mbxng for 15-20 minutes at constant conditions; [0224] component 11 was then added thereto. The resultant primary mbdure was then cooled to 50° C.
Components 13, 14, 20 and 21 were combined in a separate beaker at 25-300C to form a prembdure. After cooling the primary mbdure to 50° C., component 12, [0225] component 15, component 16, component 17 the prembdure, component 18, component 19 and component 22 were sequentially added thereto with mixing. Sodium hydro)xde was then added thereto with mixing to adjust the pH to about 5.3-5.7. The mbdure was continuously mixed and cooled to about 25-30° C. The remaining amount of deionized water was added to the fingl volume and was mwed at 500 rpm until uniform.

Example 9

Multiple Attribute Assessment Study

A large-scale consumer study was conducted to assess a variety of attributes such as cleansing ability, hair combing attributes (e.g. wet combing and dry combing); hair softness; and lather attributes (e.g. the amount of lather and the creaminess of the lather). The four formulations tested in this study ingluded: 1) the formulation prepared in accordance with Example 3; 2) “Pantene Pro-V” regular shampoo for normal hair commercially available from Procter & Gamble; 3) “Johnson's pH[0226] _5.5” regular shampoo for normal hair commercially available from Johnson & Johnson Consumer Companies, Inc.; and 4) “Johnson's pH_5.5” regular shampoo modified with a different fragrance.
For each of the four above-mentioned test products, 250 female subjects between the age of 16-65 who use regular shampoos for normal hair were selected to participate in a blinded, monadic inhome use study. After using the test product for 2 weeks, each subject completed a questionnaire which asked them to rate the overall performance of the test product as well as and various attributes associated therewith. [0227]

The following table is a summary of the results from study:

TABLE 9


% of subjects satisfied with the performance of the product in eacqh
attribute listed.

		Example #3
	pH 5.5	(base W/2 cationic
	with modified	agents & 1 silicone
pH 5.5	fragrance	agent)	Pantene

Attributes	(a)	(b)	(c)	(e)
Cleaning	88%	86% (4)	91% (3)	88%
Wet combing	71% (2)	66% (2)	83% (1) (3)	77% (4)
Dry combing	72% (2)	78% (2)	86% (1)	83%
Hair Softness	78% (2)	78% (2)	90% (1)	86%
Amount of	41%	37% (2)	47% (1) (3)	38% (4)
lather
Creaminess	14% (2)	11% (2)	27% (1) (3)	21% (4)
of lather (Very
creamy

This Example showed that the formulation of Example 3 ranked superior with respect to the subject's satisfaction in all the attributes listed above. More specifically, the formulation of Example 3 performed significantly better relative to the performance of the pH[0229] _5.5product with either the origingl and modified fragrance with respect to the following attributes: wet combing, dry combing, hair softness, cleansing, amount of lather and creaminess of the lather. The formulation of Example 3 also performed significantly superior relative to the performance of Pantene with respect to wet combing, amount of lather and creaminess of the lather. This Example showed that the subjects perceived that the formulation of Example 3 performed the best overall with respect to the attributes tested.

Example 10

Hair Softness Assessment

80 Caucasian females between the ages of 18 and 65 years old were selected to participate in a blind hair softness assessment study conducted by professional hair stylists. Prior to participating in the study, each subject did not wash their hair for a period of 24 hours prior to the study entry. All of the subjects as well as the stylist completed two different questionnaires relating to the hair quality and hair softness of each panelist before the study commenced. [0230]
The following three methods were used for purposes of assessing hair softness: 1) pat and compress hair with hands; 2) run fingers through the hair; and 3) feel the hair fibers/strands with fingers. [0231]

After 3 cc of the formulation of Example 3 was applied via a syringe onto the hair on each respective subject's head, the stylist then shampooed the hair of each respecttw subject After this procedure was repeated twice per subject, the hair of each subject was then blown until the hair was completely dried. No other styling aides were used on hair or scalp of any of the subjects. After the drying procedure, both the respectihe subject as well as the stylist conducted an independent evaluation of the respective subject's hair softness, using the Softness scale as set forth in Table 10 below. The results of the evaluations are set forth in Table 11 below.

TABLE 10


Softness Scale

Number Score	Softness Assessment

0	Not At all Soft
1	Just Barely Soft
2	Between Just Barely and Slightly
	Soft
3	Slightly Soft
4	Slightly to Moderately Soft
5	Moderately Soft
6	Moderately to Considerably Soft
7	Considerable Soft
8	Considerably to Very Soft
9	Very Soft
10	Extremely Soft

[0233]

TABLE 11

Softness assessments determine by the subject and stylist.

The numbers represent the mean score from 80 subjects.

Pre-wash softness

Evaluator score Post-Wash Score p-value

Stylist 2.74 7.44 0.0001

Subject 3.50 7.58 0.0001
It is evident from the data above that the formulation of Example 3 significantly ingreased the softness of the hair as determined independently by the stylist and the subjects. [0234]
Each respective subject as well as the stylist also conducted an independent, post-drying evaluation of the degree of softness of each respective subject's hair, using the Hair Softness Quantification Scale set forth in Table 12 below. The results of the evaluations are set forth in Table 13 below. [0235]

TABLE 12

Hair Softness Qualification Scale

Number

Scale Distinction

−1 Less Soft

0 The Same

1 Somewhat Softer

2 Twice as Soft

3 Three times as soft

4 More than Three times as

soft
[0236]

TABLE 13

Qualification of the hair softness.

The numbers below represent mean score values from 80 subjects.

Evaluator Mean Times Softer Score p-value

Stylist 2.44 0.0001

Subject 2.33 0.0001
From the data above, it is evident that the formulation of Example 3 was appro)dmately two to three times more soft as a result of shampooing with this cleansing base. [0237]

Example 11

Secondary Ion Mass Spectrometry (SIMS) to Assess Si Deposition

A formulation was prepared in accordance with the procedure set forth in Example 3, exrept that: a) the Biosil SPQ silicone agent was used instead at a concentration of I weight percent as opposed to 0.2 weight percent; b) the Salcare cationic agent was used instead at a concentration of 0.05 weight percent as opposed to 0.08 weight percent; and c) the Jaguar cationic agent was used instead at a concentration of 0.1 weight percent as opposed to 0.15 weight percent. [0238]
One hair tress was independently washed five times, followed by complete drying of the tress in between washings, with Pantene Pro-V 2-in-I shampoo for normal hair that is commercially available from The Procter and Gamble Company, and another hair tress was similarly washed with the formulation of Example 3 as modified in Example 11 and dried. [0239]
Scanning SIMS (secondary ion mass spectrometry) was then used to characterize the distribution of silicone ions from the silicone-containing polymers that were deposited on the hair. Detags of SIMS may be found in, for example, Sibilia, John, “A Guide to Material Characterization and Chemical Analysis,” Ch. 8, 185-192 (1988)(hereingfter “Sibilia”), which is ingorporated by reference herein. After placing one fiber of each tress in a Physical Electronics SIMS spectrometer, a primary ion beam was then scanned across the hair surface in order to ionize the Si molecules from the hair surface. The spectroreter then generated images revealing the distribution of Si ions on the surface of the hair. [0240]
This procedure was repeated with several hair fibers from each tress, and representative mass spectrometer images were taken of each set of hair fibers. [0241]
It is evdent from FIG. 1, which illustrates the distribution of Si ions on the hair surface that was washed with the Pantene Pro-V shampoo, that the Si ions were distributed over the surface hair fiber; however, the ions were primarily concentrated only under the scale ridge of the hair fiber. By contrast, it is evident from FIG. 2, which illustrates the distribution of Si ions on the hair surface that was washed with the modified Example 3 formulation, that the distribution of the Si ions is comparatily more homogenous than the distribution shown by the hair fibers washed with the Pantene Pro-V shampoo. [0242]
This Example showed that the cleansing composition of the present invention yielded a more homogeneous distribution of the Silicone polymers, which thereby significantly contributed to the Improved softness and body of the treated hair fibers. [0243]

Example 12

X-Ray Photoelectron Spectrometer (XPS) to Assess Polymer Thickness

After each tress of Example II was placed into a Physical Electronics x-ray photoelectron spectrometer, a beam of X-rays were scanned onto the surface of the hair fibers. Details of XPS may be found in, for example, Sibilia at 197-199, which is ingorporated by reference herein. [0244]
From the percentage of Carbon and Oxygen atoms on the hair fiber and the atomic ratios of Si:C and Si:O as determined by XPS, the thickness of the silicone polymer layer on the hair surface was estimated as shown in Table 14 below: [0245]

TABLE 14

Thickness of Silicone molecules on the hair as determined by XPS.

Thickness of Si molecules Number of

Formulation (Angstroms) monolayers

Pantene Pro-V 40-50 7-8

Modified Example 3 3 1
It is evident from the results of Table 14 that the Pantene shampoo left substantially higher levels of silicon molecular residue on the hair surface in comparison to the amount of such residue left by the modified Example 3 formulation. We believe that the higher levels of silicon deposition along the hair surface may contribute to the perception of high conditioning build-up on the hair, reduction in body, and limpness. By contrast, singe the hair treated with the modified Example 3 formulation left only one or two layers of silicon molecular residue on the surface of the hair fibers, we believe that hair treated with this formulation will likely possess attributes, such as enhanced wet and dry comb, improved rinsing performance and enhanced softness, that are superior relative to such properties possessed by hair treated with the Pantene shampoo. [0246]
Since the performance of a hair care product largely depends upon on how the product interacts with the outermost layer of the hair fiber, this example indicated that the modified Example 3 shampoo will have a superor performance relative to that of the Pantene shampoo based upon a chemical and elemental analysis of the respectie shampoo's residue left at the interface between the hair surface and the air. [0247]

Example 13

Instron Ring Comoression Study to Assess Hair Softness and Body

The ring compression technique, which measures the energy required to pull hair tresses through various sized rings both before and after the tresses are shampooed, is a well known technique as described in Wergmann & Kamuth, [0248] Pringiples of Polymer Science and Technology in Cosmetics and Personal Care, Chapter 12 “Evaluation Methods for Conditioned Hair” 554-556 (1999), which is ingorporated herein by reference, for assessing hair softness and body. See, e.g., Garcia et al, “Measurement of Bulk Compressibility and Bulk Resiliency of a Hair Mass,” 10^thIFTSCC Congress, Sidney, Australia (1978), which is ingorporated by reference herein. The apparatus used in this technique consisted of an Instron tensile tester, model 1122, which is connected to ring devices of varying diameters.
After 15 brown European hair tresses were penned with a tight pern, each tress was pulled through a metal ring having a 1.5″ inner diameter twice. The energy required to pull the tress through the ring was then recorded via the Instron tester. The tresses were then manually loosened and pulled through a second metal ring having a 1.0” inner diameter twice. The energy required to pull the tress through this second ring was then recorded via the Instron tester. [0249]
The “Dry Pull Energy” required to pull a tress through a given ring may be expressed in terms of the difference between the energy exerted to pull a tress through the same ring twice. This value is a measure of the degree of body or rebound of the hair tress after compression. Higher values of Dry Pull Energy indicate greater hair body. [0250]
The difference between the Dry Pull Energies required to pull each tress through the 1.0” and the 1.5″ diameter rings, respectively, is an indication of the softness of the hair tress. The greater the difference between the difference in the Dry Pull Energies indicates that the respective hair tress is relatively more compressible or softer. The difference in the Dry Pull Energies resulting from the tress being pulled through a 1.0″ inch ring and then through a 1.5″ inch diameter ring are shown in Table 15 and 1I below for the dry permed hair. [0251]
The tresses were then shampooed once with one of the following products: 1) the formulation of Example 3; 2) “Pantene Pro-V” shampoo for normal hair, and 3) “Shiseido Super Mild” shampoo commercially available from Shiseido Fine Toiletries Co., LTD. A minimum of 3 tresses was used for each product. After the tresses were shampooed and blown completely dry, the tresses were manually Ioosened to separate the indwvidual hair fibers. The tresses were then pulled through the rings in accordance wlih the procedures as described above. [0252]
The difference in the Dry Pull Energies resulting from the tress being pulled through the same size ring twice, i.e. a 1.0″ diameter ring and independently a 1.5″ diameter ring, both before the hair is shampooed as well as after the hair is both shampooed and dried are shown in the Table 17 below. [0253]

TABLE 15

Dry Pull Energy (mJ)

Dry Pull Dry Pull Difference

Energy Energy Between Dry Pull

Before After Energy Before and

Test Product Shampooing Shampooing After treatments

Example 3 16.0 10.0 6.0

Pantene Pro V 20.3 16.8 3.5

Shiseido Super Mild 7.99 7.90 0.09
[0254]

TABLE 16

Statistical significance of represented by p-values

determined by the Student's t-test*.

Formulations p-value

Example 3 vs. Pantene >0.000

Example 3 vs. Shiseido 0.026

It is evident from the data above that the formulation of Example 3 showed the greatest difference in Dry Pull Energies, which indicates that this formulation is superior with respect to the other two tested commercial formulations with respect to delivering softness to the hair fibers.

TABLE 17


Dry Pull Energy (mJ)

Difference

Dry Pull		between Dry	Dry Pull		between Dry
Energy	Dry Pull	Pull	Energy	Dry Pull	Pull
Before	Energy After	Energies	Before	Energy After	Energies
shampooing	Shampooing	before and	shampooing	Shampooing	Before and
Pulled	Pulled	after	Pulled	Pulled	After
through 1.0″	through 1.0″	shampooing	through 1.5″	through 1.5″	Shampooing

Test Product	Ring	Ring	(1.0″ ring)	Ring	Ring	(1.5″ ring)

Example 3	2.76	1.31	1.45	2.20	1.07	1.13
Pantene Pro V	2.39	1.56	0.83	2.19	1.43	0.76
Shiseido	1.26	1.05	0.21	1.34	0.93	0.41
Super Mild

It Is evident from the data in Table 17 above that the formulation of Example 3 showed the greatest difference in Dry Pull Energy before and after shampooing regardless of the ring size employed. This indicates that the formulation of Example 3 exhibited the greatest amount of body and/or rebound relatie to that possessed by the other two commercial products. [0256]

Example 14

Dynamic Vapor Sorption Studies to Determine Moisture Uptake

Dynamic Vapor Sorption (DVS), Surface Measurement Systems, Ltd., was used to determine the water absorption and moisture desorption on hair fibers after application of a composition thereto. [0257]

Four hair tresses were individually shampooed twice with 3 g of one of the formulations prepared in accordance with one of the following examples as shown in Table 18 below: 1) modified Example 3; 2) Example 6; 3) modified Example 7; and 4) modified Example 6. After blow drying the hair tresses for 2 minutes, the tresses were then cut into segments 5-7 mm in length and weighed using a DVS Cain microbalance. The weights of the hair samples ranged between approximately 30 mg to 40 mg/sample. The hair samples were then placed into the DVS humidity chamber and equilibrated at 0% relative humidity at 25° C. ovemight. The relative humidity in the chamber was then ingreased to 10% RH until equilibation occurred. The relative humidity was then ingreased to 95% RH in appro)dmately 10% RH intervals. The weight of the hair samples was then measured at each interval after each equilibration using the Cain microbalance. The relative humidity was then reduced back to 10% RH in ˜10% RH intervals. The weight of the hair fibers at each 10% RH interval is an indication of the water moisture absorbed and of the moisture retained by the hair samples. The water retaining capacity is the difference between the measured weight of water retained by the hair fibers at a given relative humidity during the ascent of the relative humidity versus measured weight of water retained by the hair fibers at a given relative humidity during the descent of the relative humidity. Higher values of water retaining capacity indicate the presence of surface water on the hair fiber, which tends to create limpness of the hair or ingrease interfiber adhesion. Lower values water retaining capacity indicated the reduction of water by the hair fiber, which tend to ingrease the body of the hair. A summary of the water retaining capacities is shown in Table 19 below.

TABLE 18


Summary of formulations tested and modifications.

	Number of	Number of	Modifications in
Formulations	Cationic	Silicones	Formulation

Modified Example 3	2	1	Jaguar is 0.10 wt %
			instead of 0.15 wt %
Example 6	0	0	No modifications
Modified Example 7	0	1	No PEG 14M
Modified Example 6	0	0	No PEG 14M

TABLE 19


Water Retaining Capacities

	Moderate Relative	High Relative
	Humidity (calculated at	Humidity (calculated at
Test Products	50% RH)	80% RH)

Untreated	2.34	1.80
Modified example 3	2.14	1.65
Example 6	2.53	1.88
Modified Example 7	2.34	1.82
Modified example 6	2.47	1.99

It is evident from the data above that the formulation of Example 3 as modified above in Table 18 possessed superior body properties at both moderate and high relative humidity conditions. By contrast, the formulations that did not contain a cationic agent and/or a silicone agent did not perform relatively as well. This Example showed that formulations exhibiting superior body preferably contain both at least two cationic agents as well as one silicone agent. [0260]

Example 15

Determination of Skin Permeation

Experoments were conducted to determine the deposition of actives into the skin from various shampoo compositions. To determine penetration of actives, in vitro skin permeation studies were conducted using non-occluded Franz diffusion chambers. [0261]
Human cadaver skin, microtomed to 400 μm, were mounted on Franz diffusion cells containing a receptor medium composed of a citric acid phosphate buffer or a phosphate buffered solution (depending being monitored). The receptor capacity was 5 ml and the cell surface was 0.636 cm2. The mpartment was maintained at 37° C. during the experiment. [0262]
In a tube, 50 μl of each formulation as shown in Tables 1 and 2 through 6 were diluted with 50 μl of 37° C. eater. This solution was then rubbed onto the epidermal surface of the mounted skin for 30 seconds and allowed to sit thereon for 5 minutes. The solution was then rinsed from the surface three times with 37° C. water and then swabbed twice with dry cotton swabs. At 24 hours after the topical applbtion of the formulation, the surface of the skin was rinsed three times with methanol or distilled water soaked cotton swabs (depending on the active to be monitored), and then swabbed three times wtkh three dry cotton swabs. After removing the skin from the diffusion cell, the epidermis and dermis were separated, chopped and placed into separate vials containing an extraction solution and sonicated in a bath sonicator for 30 minutes. After sonication of the epidermis, dermis and swabs, respectively, each sonicated sample was assayed using a Walters high pressure liquid chromatography (“HPLC”). Penetration of the actve into the skin was calculated based upon a percentage of the applied dose and the amount of active delivered into the epidermis or dermis per surface area. For these studies, the penetration of a lipophilic agent, elubiol was investigated. Also the penetration of a hydrophilic agent, salicylic acid was investigated. [0263]

shown in Table 20 below, the formulations investigated were the formulations prepared in accordance with the procedures set forth in Example 1, and Examples 3 through 8. Table 21 shows the amount of elubiol penetrated into the skin (epidermis and dermis) after topical application of the formulations set forth in Table 20 in accordance with the procedure set forth above.

TABLE 20


Summary of Depositing Agents in each compositions

Example		Number of	Number Of
#	Depositing Agents (Additives)	Cationic	Silicones

1	Jaguar, Salcare	2	0
3	Jaguar, Salcare, Biosil SPQ	2	1
4	Jaguar, Salcare, Merquat,	3	2
	Biosil SPQ, Biosil Cetyl
6	None	0	0
7	Biosil Basic SPQ	0	1
8	Biosil SPQ, Biosil Cetyl	0	2

TABLE 21


Levels of elubiol in the skin (epidermis and dermis) after topical application of various
shampoo formulations.

Epidermis

Percentage

Dermis

Total Skin Delivery

Amt/Surface

of Applied

Percentage of

Amt/Surface

Percentage

Formulations	Area	Dose	Amt/Surface	Applied Dose	Area	of Applied
Number tested	(μg/cm²)	%	Area (μg/cm²)	%	(μg/cm²)	Dose %

#1	1.849 ± 1.316	0.510 ± 0.363	0.139 ± 0.058	0.038 ± 0.016	1.988	0.549
#3	3.471 ± 2.009	1.039 ± 0.601	0.173 ± 0.051	0.052 ± 0.015	3.644	1.091
#4	8.70 ± 3.35	2.433 ± 0.936	0.121 ± 0.021	0.034 ± 0.006	8.822	2.466
#6	0.412 ± 0.051	0.111 ± 0.014	0.089 ± 0.023	0.024 ± 0.006	0.502	0.135
#7	0.50 ± 0.14	0.127 ± 0.036	0.398 ± 0.067	0.101 ± 0.017	0.899	0.227
#8	0.25 ± 0.02	0.064 ± 0.06	0.034 ± 0.006	0.009 ± 0.002	0.279	0.072

TABLE 22


Statistical significance of elubiol permeation as represented by p-values
determined by the Student's t-test*.

Formulations	Epidermis	Dermis

4 Vs 6	One Tail = 0.001	One Tail = 0
	Two Tail = 0.003	Two Tail = 0
4 Vs 3	One Tail = 0.011	One Tail = 0
	Two Tail = 0.022	Two Tail = 0
4 Vs 1	One Tail = 0.002	One Tail = 0
	Two Tail = 0.004	Two Tail = 0

The results of Table 21 are summarized below in Table 23.

TABLE 23


Ranking (from best to worst) of the formulations with respect
to elubiol delivery into the skin (epidermis and dermis).

	Number of		Total % of
Ranked	Cationic	Number Of	Elubiol
Example	Agents in	Silicons in	Delivered into
Number	Composition	Composition	the Skin

4	3	2	2.466
3	2	1	1.091
1	2	0	0.549
7	0	1	0.227
6	0	0	0.135
8	0	2	0.072

This Example showed that a formulation (Formnulation 4) containing 3 cationic agents and 2 silicones delivered 2.466% of the applied dose of elubiol into the skin. However, when a formulation (Formnulation 3) containing 2 cationic agents and 1 silicone were ingorporated with the cleansing shampoo base, the percentage of elubiol delivered decreased to 1.091 %, over a 2.2 fold decrease in delivery. When no cationic agents were ingorporated into the cleansing base (Formulation 6), the elubiol permeation surprisingly decreased to 0.135 %, an 18.2 fold decrease over the delivery exdiibited by Formulation 4. [0268]
It is also evident from this Example that there is a synergistic effect on the permeation of hydrophobic benefit agents In combingtion with cationic agents and water-soluble silicones. Formuiatlons that contain either a cationic agent alone or a sgiconeagent alone did not achieve the desired effect of enhanced permeation of the benefit agent. This Example showed that the combingtion of two or more cationic agents with one or more water soluble silicone agents was superior with respect to permeation of hydrophobic actives into the skin. [0269]

The amount of salicyic acid penetrated into the skin (epidermis and dermis) after topical application of the Formnulations is set forth in Table 24, wherein the formulations were prepared in accordance with the procedure set forth above.

TABLE 24


Levels of salicylic acid in the skin after topical application of various shampoo
formulations

Epidermis

Percentage

Dermis

Total Skin Delivery

Amt/Surface

of Applied

Percentage of

Amt/Surface

Percentage

Formulation	Area	Dose	Amt/Surface	Applied Dose	Area	of Applied
Number tested	(μg/cm²)	%	Area (μg/cm²)	%	(μg/cm²)	Dose %

#4	11.50 ± 5.07	1.508 ± 0.664	0.412 ± 0.222	0.054 ± 0.029	11.912	1.562
#6	4.83 ± 2.52	0.604 ± 0.315	0.195 ± 0.141	0.024 ± 0.018	5.027	0.629
#3	9.67 ± 5.61	1.326 ± 0.769	0.419 ± 0.170	0.057 ± 0.023	10.093	1.383
#1	5.23 ± 1.27	0.675 ± 0.293	0.473 ± 0.200	0.061 ± 0.026	5.707	0.700
#7	2.36 ± 0.37	0.303 ± 0.048	0.137 ± 0.028	0.018 ± 0.004	2.493	0.321
#8	0.93 ± 0.20	0.118 ± 0.025	0.022 ± 0.022	0.003 ± 0.003	0.95	0.121

TABLE 25


Statistical significance of salicylic acid permeation
as represented by p-values determined by the Student’s t-test*.

Formulations	Epidermis	Dermis

4 Vs. 6	One Tail = 0.011	One Tail = 0
	Two Tail = 0.021	Two Tail = 0
4 Vs. 3	One Tail = 0.373	One Tail = 0
	Two Tail = 0.746	Two Tail = 0
4 Vs. 1	One Tail = 0.066	One Tail = 0
	Two Tail = 0.132	Two Tail = 0

The results of Table 24 are summarized below in Table 26.

TABLE 26


Ranking (from best to worst) of the formulations with respect
to salicylic acid delivery into the skin (epidermis and dermis)..

		Number	Total %
Ranking Best to	Number of	Of	of Salcyclic acid
Worst	Cationic Agents	Silicones	Delivered into the Skin

4	3	2	1.562
3	2	1	1.383
1	2	0	0.700
6	0	0	0.629
7	0	1	0.321
8	0	2	0.121

It is evident from Tables 24 and 26 above that Formnulation 4, which contained a cleansing base ingorporated with three cationic agents and two water-soluble silicones agents (Example 4), delivered the highest levels of salicylic acid into the skin. It is further evident that in the formulation containing only silicone agents ingorporated with the cleansing base (Example 7 and 8), the level of salicylic acid delivered into the skin was comparatively low. Notably, the cleansing base without the cationic agents and silicone agents (Example 6) possessed superior salicylic acid delivery capabilities in comparison with formnulations containing only silicone agents (Example 7 and 8). Formulation 4, which contained both cationic agents and silicone agents, performed 4.9 times better than formulations without cationic agents (Example 6) and 1.62 times better than formulations containing only cationic agents (Example 1). [0273]
This example demonstrated that the combingtion of elubiol and salicylic acid in a cleansing shampoo with 2 or more cationic agents and 1 or water soluble silicone agents performed superior with respect to delivering the elubiol and salicylic acid into the skin. Thus, the composition of this invention affords a method of regulating the delivery of both hydrophobic and hydrophilic actives into the skin. [0274]

Claims

We claim:

1. A cleansing composition comprised of:

a) at least one water soluble silicone agent:

b) at least one cationic conditioning agent: and

c) at least one detergent.

2. The composlion of claim 1 wherein the water soluble silicone agents are selected from water soluble dimethicones substituted with fatty acid moieties, water soluble silicone quatemiums, and mixtures thereof.

3. The composition of claim 1 wherein the dirnethicones are substituted with fatty acid moieties selected from fatty acids having from about 5 carbon atoms to about 30 carbon atoms and the silicone quatemiums contain about 6 carbon atoms to about 20 carbon atoms.

4. The composition of claim 1 wherein the water soluble volatile silicone agents are selected from the group consisting of polydimethyisiloane, hexamethyidisiloxne, cyclomethicone fluids, and mixtures thereof.

5. The composition of claim 1 wherein the water soluble non-volatile silicone agents are selected from the group consisting of cetyl triethylmonium dimethicone copolyol phthalate, stearalkonium dimethicone copolyol phthalate, dimethicone copolyol having the following structure:

wherein:

qua is an integer from about 1 to about 7000;

q” is an integer from about 1 to about 5000;

R₉may be any water soluble group such as:

a) a fatty alcohol having from about 8 carbon atoms to about 30 carbon atoms;

b) a fatty acid having from about 8 carbon atoms to about 30 carbon atoms, and derivatives thereof;

c) a crosslinked water soluble polymer such as mercaptol propyl copolymer, d) a cationic moiety, e.g. trimonium chloride; JBP452

e) propyl PG Betaine;

f) polypeptides such as polysarcosine, and e) mbtures thereof, dimethicone copolyol acetate, dimethicone copolyol lactate, dimethicone copolyol laurate, dirnethicone copolyol methyl ether, dimethicone copolyol octyl dodecyl citrate, hydrolyzed soy protein/dirnecinone copolyol acetate, dimethiconol, and mixtures thereof.

6. The composition of claim 2 wherein the water soluble silicone quatemiums are selected from the group consisting of silicone quatemium 13, silicone quatemium 40, quatemium 80, and mixtures thereof.

7. The composition of claim 1 wherein the water soluble silicone agents inlude slicone quatemium 13, cetyl triethylmonium dimethicone copolyol phthalate, stearalkonium dimethcone copolyol phthalate, and mixtures thereof.

8. The composition of claim 1 comprised of, based upon the total weight of the composition,

a) from about 0.001 percent to about 20 percent of water soluble silicone agents;

b) from about 0.01 percent to about 10 percent of cationic conditioning agents; and

c) from about 0.01 percent to about 30 percent of detergent.

9. The composition of claim 1 comprised of, based upon the total weight of the composition,

a) from about 0.01 percent to about 5 percent of water soluble silicone agents;

b) from about 0.1 percent to about 5 percent of cationic conditioning agents; and

c) from about 5 percent to about 20 percent of detergent.

10. The composition of claim 1 wherein the cationic conditioning agent is selected from the group consisting of a cationic cellulose derivatie; a cationic guar derivati; a homopolymer or copolymer of a cationic monomer selected from:

a. a monomer having the formula

wherein

R is H or CH₃,

Y is O or NH,

R₁is an alkyene group hawig from about 2 to about 6 carbon atoms,

R₂. R₃and R₄are each independently an alkyt group or hydmrxyaliq pup having from about I to about 22 carbon atoms, and

X is a monovalent anion selected from halide and alkyl sulfate hatig from about 1 to about 4 carbon atoms, or

b. diallyldimethylammonium chloride,

and mixtures thereof.

11. The composition of claim 10 wherein the cationic conditioning agent is s ieled from the group consting of polyquatemium-10, guar hydroxAppyltrronium chloride, compounds derid from acrylamidopipyl tronium chloride/acriamide copolymer, polyquatemium-6, polyquateeum7, polyquatemium47, and mixtures thereof.

12. The composition of claim 11 wherein the cationic conditioning agent is selected from the group consisting of acrylamidopropyltrimonium chloride/acrylamide copolymer, guar hydro4Wopy monium chloride, and mixtures thereof.

13. The composition of claim 1 wherein the detergent is a surfactant, soap, or mbdure thereof.

14. The composition of claim 1 wherein the surfactant is comprised of at least one anionic surfactant.

15. The composition of claim 1 wherein the detergent is comprised of, based upon the total weight of the detergent,

a) from about 1 percent to about 20 percent of an anionic surfactant;

b) from about 1 percent to about 10 percent of an amphoteric surfactant;

C) from about 0 percent to about 4 percent of a cationic surfactant; and

d) from about I percent to about 7 percent of a nonionic surfactant.

16. The composition of claim 1 wherein the detergent is comprised of, based upon the total weight of the detergent,

a) from about 80 percent to about 95 percent of an anionic surfactant selected from the group consisting of alkyl sulfates, alkyl ether sulfates, and mixtures thereof wherein the alkyl groups have from about 8 carbon atoms to about 18 carbon atoms; and

b) from about 5 percent to about 15 percent of an amphoteric surfactant containing at least a cocamidopropyl betaine.

17. The composition of claim 1 wherein the detergent is comprised of, based upon the total weight of the detergent,

a) from about 70 percent to about 90 percent of an anionic surfactant selected from the group consisting of sodium PEG7 olive oil carboxaate, alkyl sulfates, alkyl ether sulfates, and mixtures thereof wherein the alkyl group has from about 8 carbon atoms to about 18 carbon atoms;

b) from about 10 percent to about 25 percent of an amphoteric surfactant containing at least a cocamidopropyl betaine; and

c) from about 2 percent to about 10 percent of a cationic surfactant.

18. The composition of claim 1 further comprising at least one benefit agent.

19. The composition of claim 18 wherein the benefit agent is selected from the group consisting of elubiol, 6(1-piperidinyl)-2,4pyrimidinediamine-3-oxdde, shale oil and derivatives thereof, fingsteride, ketoconazole, salicylic acid, zing pyrithione, coal tar, benzoyl pero)dde, selenium sulfide, hydrocortisone, sulfur, menthol, pramo)dne hydrochloride, tricetylammonium chloride, polyquatemium 10, panthenol, panthenol triacetate, vitamin A and derivatives thereof, vitamin E and dervatives thereof, vitamin C and derivatives thereof, vitamin D and derivatives thereof, vitamin E and derivatives thereof, vitamin K and derivatives thereof, keratin, lysine, arginine, hydrolyzed wheat Eroteins, hydrolyzed silk proteins, octyl methoxyinnamate, oxybenzone, minoxddil, titanium dio)dde, zing dioxide, retinol, erthromycin, tretinoin, and mixtures thereof.

20. The composition of claim 18 further comprising, based upon the total weight of the composition, from about 0.001 percent to about 20 percent of the benefit agent

21. The composition of claim 18 further comprising a suspending agent.

22. The composition of claim 21 wherein the composition is comprised of, based upon the total weight of the composition, from about 0.01 percent to about 5 percent of the suspending agent.

23. The composition of claim 21 wherein the suspending agent is selected from the group consisting of carbomer, hydroxyethyl cellulose, methylvinylether/maleic anhydride copolymer crosslinked with 1 ,9decadiene PolyVMIMA (PVMTMA decadiene crosspolymer), Acrylates/Aminoacrylates C10-30 AJkyl PEG20 Itaconate Copolymer, and mixtures thereof.

24. The composition of claim 1 in the form of a shampoo, a gel, a bath, a cream, a lotion, or a mousse.

25. The use of the composition of claim 1 to cleanse the skin, hair and/or nails.

26. A delivery system for delivering benefit agents into andtor onto the hair, nals, and scalp corTs of:

a) at least one water soluble sione agent, and

b) at least one cationic conditionwig agent

27. The delihry system of claim 26 wherein the delivery system is compssed of, based upon the total weight of the delivery system:

a) from about 0.001 percent to about 10 of at least one water soluble saioxne agent, and

b) from about 0.001 percent to about 5 percent of at least one cationic condo compounds.

28. The dewiiy system of claim 28 wherein the water soluble silicone agent contais at least a silcone quatemium-13, a cetyl triethylmonium dimethicone copolyol phthalate, or a mbdure thereof and the cationi condiloning agent contains at least a guar hydroxypropyltrimonium chloride, an acrylaminopropyltrimonium chloride/acrylamide copolymer, or a mbdure thereof.

29. A method for enhancing the deposition of benefit agents which comprises topically administering to a human or animal a composition comprised of:

a) a deliwery system comprised of

i) at least two cationic conditioning compounds selected from the group consisting of guar hydroxypropyltrimonium chloride, acrylaminopropyttrimonium chloride/acryiamide copolymer, and mixtures thereof;

ii) at least one water soluble silicone compound comprised of silicone quatemium-13; and

b) an effective amount of a benefit agent to a desied location on the skin, hair, and/or nals.

30. The method of claim 29 wherein the benefit agent is elubiol, shale oil and derivatives thereof, 6 (1-piperidinyl)-2,4pyrimidinediamine-3-oxdde, fingsteride, ketoconazole, salicylic acid, zing pyrithione, coal tar, benzoyl peroxdde, selenium sulfide, hydrocortisone, sulfur, menthol, pramoxine hydrochloride, tricetylammonium chloride, polyquatemium 10, panthenol, panthenol triacetate, vitamin A and dervtives thereof, vitamin B and derivatives thereof, vitamin C and derivatives thereof, vitamin D and derivatives thereof, vitamin E and derivatives thereof, vitamin K and derivatives thereof, keratin, lysine, arginine, hydrolyzed wheat proteins, hydrolyzed sik proteins, octyl methoxycinnamate, oxybenzone, minoANI, titanium dioxide, zing dio)xde, retinol, erthromycin, tretinoin, and mixtures thereof.

31. The method of daim 29 wherein the composition is further comprised of a detergent

32. A method for depositing a thin coating of conditioner on a hair fiber, comprised of:

i) at least two cationic conditioning compounds selected from the group consiing of guar hydroxpropyftrimonium chloride, acrylaminopropyltrimonium chloride/acrylamide copolymer, and mixtures thereof;

i) at least one water soluble silicone compound comprised of cetyl trlylnoi dire copolyol phthalate; and

ill) a hydrophiiic benefit agent to a desired locaon on the hair of a human or animal.

33. A method for treating hair loss comprising topically administering to a human or animal at a desired area for treating hair loss a composition comprised of, based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

ii at least one cationic conditioning agent; and

B. an effective amount of a hair loss treatment agent.

34. The method of claim 33 wherein the composition is further comprised of a detergent.

35. The method of claim 33 wherein the hair loss treatment agent is selected from minoxdil, N%- cyano-N-(tert-pentyl)-N′-3-pyridinylguanidine, diazoxide, vitamin E, vitamin C, vitamin E acetate, vtamin C paimitate; erythropoietin; prostaglandin El, prostaglandin F2-alpha; oleic acid; heat shock protein 27 (“HSP 27”), heat shock protein 72 (“HSP 72”); verapamil HCL, nifedipine, diltiazemamiloride, cyclosporin, Fk-506; fingsteride, 17-beta estradiol, EGF, FGF, benoxaprofen, tretinoin, ILL, IL-1 alpha, and IL-1 beta ICAM, betametasone, aloe, clove, ginseng, rehmannia, swertia, sweet orange, zanthoxylum, elubiol, ketoconazole, zing pyrithione; streptomycin; cycloheximide; or mixtures thereof.

36. The method of clairn 33 wherein the hair loss treatment agent is 6(1-piperidinyl2,4 pyrimidinediamine-3-oxdde, N′-cyano-N-(tert-pentyl)-N′-3-pyridinyl-guanidine, a retinoid and derivatives thereof, fingsteride, mino)ddil, ketoconazole, or mixtures thereof.

37. The method of claim 33 wherein the hair loss treatment agent is present in an amount, based upon the total weight of the composition, from about 0.001 percent to about 20 percent.

38. A method for inhibiting hair growth comprising topically administering to a human or animal at a desired area for inhibiting hair growth a composition comprised of, based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

i) at least one cationic conditioning agent; and

B. an effective amount of a hair growth inhibiting agent

39. The method of clain 38 wherein the hair growth inhibiting agent is selected from ant asic agents; anticoagulants; antkthyroid drugs; lithium; lithium carbonate; interferons; retinoids; antihyperlipidaemic drugs; thallium; mercury; albendazole; allopurinol; amiodarone; amphetamines; androgens; bromocriptine; butyrophenones; carbamazepine; cholestyramine; cimetidine; clofibrat; danazol; desipramine; dbqrazine; ethambutol; etionamide; fluoxatine; gentamicin; gold salts; hydantoins; ibuprofen; impramine; immunoglobulins; indandiones; indomethacin; intraconazole; levadopa; maprotiline; methysergide; metoprolol, metyrapone; nadolol;, nicotinic acid; potassium thiocyanate; propranolol, pyridostimine; salicylates; sulfasalazine; terfenadine; thiamphenicol; thiouracils; trimethadione; troperanol; valproic acid or mixtures thereof.

40. The method of claim 38 wherein the hair growth inhibing agent is a serine protease, retnol, isotretinoin, betamethisone, alpha-tocophenol and derivatives thereof, or a mbdure thereof.

41. The method of claim 38 wherein the hair growth inhibiting agent is present in an amount, based upon the total weight of the composition, from about 0.001 percent to about 20 percent.

42. The method of claim 38 further comprising a detergent.

43. A method for treating or minimizing the effects of aging comprising topically administering to a human or animal at a desired area a composition comprised of, based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

ii) at least one cationic conditioning agent; and

B. an effective amount of an antiaging active agent.

44. The method of claim 43 wherein the antiaging active agent is selected from sunscreens; retinoids and derivatives thereof; vitamins and derivatives thereof; antioxddants; hydrocarboxy acids; botanical extracts; or mixtures thereof.

45. The method of claim 43 wherein the anti-aging active agent is retinol, tretinoin, or mixtures thereof.

46. The method of claim 43 wherein the antiaging active agent is present in an amount, based upon the total weight of the composition, from about 0.01 percent to about 10 percent.

47. The method of claim 43 wherein the composition is further comprised of a detergent.

48. A method for treating acne comprising topically administering to a human or animal at a desired area a composition comprised of, based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

ii) at least one cationic conditioning agent; and

B. an effective amount of an anti-acne active agent.

49. The method of claim 48 wherein the ant-acne actve agent is selected from imidazoles; retinoids; salicylic acid; benzoyl peroxde; antibiotics; antiandrogens; 5-alpha-reductase isotypes; ants inflammatory agents; botanical earacts; or mixtures thereof.

50. The method of claim 48 wherein the ant-acne active agent is retinol, elubil, an anIbitJ salicylic acid or mixtures thereof.

51. The method of claim 48 wherein the anti-acne active agent is present in an amount, based upon the total weight of the composition, from about 0.01 percent to about 10 percent

52. The method of claim 48 wherein composition is further comprised of a detergent.

53. A method for depigmenting skin comprising topically administering to a human or aningl at a desired area a composition comprised of, based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

j.) at least one cationic conditioning agent; and

B. an effective amount of a depigmentation active agent.

54. The method of claim 53 wherein the depigmentation active agent is selected from retinoids and derivaties thereof; kojic acid and its derivatives; hydroquinone and derivatives thereof; transeamic acid; vitamins; azelaic acid; botanical extracts or mixtures thereof.

55. The method of claim 53 wherein the depigmentation active agent is kojic acid, retinol, hydroquinone, transexamic acid or mixtures thereof.

56. The method of claim 53 wherein the depigmentation active agent is present in an amount, based upon the total weight of the composition, from about 0.01 percent to about 10 percent.

57. The method of claim 53 wherein the composition is further comprised of a detergent.

58. A method for treating the diseases of dandruff, seborrheic dermatitis, and psoriasis and/or the symptoms associated therewith comprising topically administering to a human or animal at a desired area a composition comprised of, based upon the total weight of the composition,:

A. a delivery system comprised of

i.) at least one water soluble silicone agent;

h) at least one cationic conditioning agent; and

B. an effective amount of a benefit agent selected from the group consisting of an anti, dandruff agent, an antiseborrheic dernatits agent, an antpsoriasis agent, and mixtures thereof.

59. The method of claim 58 wherein the anti-dandruff agent, the antiseborrheic derfnattis agent, and the antipsoriasis agent are selected from zing pyrithione, selenium sulfide, sulfur, sulfonated shale oil; saliclic acid; coal tar, povidone-iodine, imidazoles such as ketoconazole, dichlorophenyl irnidazolodioxalan, clotrimazole, itraconazole, miconazole, climbazole, tioconazole, sulconazole, butoconazole, fluconazole, miconazolenkdrite and any possible stereo isomers and dervatives thereof such as anthralin; piroctone olamine (Octopiro4; selenium sulfide; cidopirox olamine; antIsOpiasis agents; vitamin A analogs; cortisteroids and mixtures thereof.

60. The method of claim 58 wherein the antiandruff agent, the anti-seborrheic dematits agent, and the antipsoriasis agent are selected from elubiol, ketoconazole, coal tar, saticyli acid, zing pyrithone, selenium sulfide, hydrocoitisone, sulfur, menthol, pramo)dne hydrochloride and mixtures thereof.

61. The method of claim 58 wherein the anti-dandruff agent, the antiseborrheic dermatitis agent, and the anti-psoriasis agent are present in an amount, based upon the total weight of the composition, from about 0.001 percent to about 10 percent.

62. The method of claim 58 wherein the composition is further comprised of a detergent