US20080149124A1 - Particulate material dispensing hairbrush with combination bristles - Google Patents
Particulate material dispensing hairbrush with combination bristles Download PDFInfo
- Publication number
- US20080149124A1 US20080149124A1 US11/926,667 US92666707A US2008149124A1 US 20080149124 A1 US20080149124 A1 US 20080149124A1 US 92666707 A US92666707 A US 92666707A US 2008149124 A1 US2008149124 A1 US 2008149124A1
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- United States
- Prior art keywords
- brush
- bristles
- head
- aperture
- cover
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
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-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K13/00—Devices for grooming or caring of animals, e.g. curry-combs; Fetlock rings; Tail-holders; Devices for preventing crib-biting; Washing devices; Protection against weather conditions or insects
- A01K13/002—Curry-combs; Brushes
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K13/00—Devices for grooming or caring of animals, e.g. curry-combs; Fetlock rings; Tail-holders; Devices for preventing crib-biting; Washing devices; Protection against weather conditions or insects
- A01K13/003—Devices for applying insecticides or medication
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
- A46B11/001—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs
- A46B11/0013—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs dispensing by gravity or by shaking
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
- A46B11/001—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs
- A46B11/002—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs pressurised at moment of use manually or by powered means
- A46B11/0055—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs pressurised at moment of use manually or by powered means with a reciprocating piston or plunger acting as the pressurising means
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
- A46B11/001—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water with integral reservoirs
- A46B11/0062—Brushes where the reservoir is specifically intended for being refilled when empty
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B11/00—Brushes with reservoir or other means for applying substances, e.g. paints, pastes, water
- A46B11/0072—Details
- A46B11/0079—Arrangements for preventing undesired leakage or dispensing
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/555—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells
- A61K47/556—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound pre-targeting systems involving an organic compound, other than a peptide, protein or antibody, for targeting specific cells enzyme catalyzed therapeutic agent [ECTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/66—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid the modifying agent being a pre-targeting system involving a peptide or protein for targeting specific cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A46—BRUSHWARE
- A46B—BRUSHES
- A46B2200/00—Brushes characterized by their functions, uses or applications
- A46B2200/10—For human or animal care
- A46B2200/104—Hair brush
Definitions
- This invention relates to a brush and a combination of bristles secured to the base.
- Various hair care utensils have been devised for grooming, cleaning, treating, medicating and otherwise taking care of human or pet hair, including utensils such as combs and brushes.
- hair grooming utensils include various spraying devices, such as manual pump sprays, pressurized aerosol containers, etc. These utensils are employed for applying hair coloring, cleansing solutions, medicinal compositions to treat various ailments, etc.
- Conventional brushes have a plurality of bristles arranged in various 2-dimensional patterns. While these brushes are effective for hair grooming, they cannot apply significant quantities of a liquid or other materials. Conventional brushes are also less than desirable for applying medicinal or other treatment compositions to hair and scalp. Moreover, most conventional brushes include a plurality of bristles of the same flexibility and stiffness. This is less than advantageous since transferring a particulate material to hair and scalp requires stiff bristles to part and separate the hair, and soft bristles to capture and deposit a particulate material to the hair and scalp.
- a brush for stroking hair and collecting and depositing a particulate material on hair and scalp. It is also desirable to have a brush that is capable of applying medicine, cleaning solutions and other treatment material to the hair, skin or scalp, as the brush is drawn through the hair.
- a brush having a head with a reservoir formed therein and at least one aperture formed in the head for opening the reservoir to the exterior of the head.
- the inventive brush also includes a plurality of bristles mounted on the head for transferring material dispensed from the reservoir through the at least one aperture in the head as the brush is drawn through human or animal hair.
- the inventive brush includes a fill and/or refill aperture formed in the head and a cap releasably engageable with the refill aperture.
- the brush may also include a cover movably mounted on the head for closing an aperture in the head with the cover movable between a first position for closing the aperture, and a second position for opening the aperture.
- the inventive brush includes a plurality of soft flexible bristles mounted along the head and surrounding the at least one aperture. These bristles are suitable for receiving materials that are dispensed through at least one aperture.
- the brush of the invention preferably includes a second group of stiffer, more rigid bristles disposed about the soft flexible bristles. In one form, the inner disposed bristles protrude beyond the height of the outer bristles.
- the inventive brush may include a vibration mechanism for vibrating the head in order to enhance migration of material from the reservoir to the bristles during use of the brush.
- Yet another object of the invention is to provide an improved hairbrush having bristles of two or more different types.
- Yet a further object of the invention is to provide an improved hair brush that is capable of applying medicine, cleaning solutions, powders and other treatment to the hair, the skin or scalp, as the brush is being drawn through the hair.
- FIG. 1 is a front elevational view of the hairbrush of the invention and depicting the movable cover mounted on the brush head and disposed in a first position for closing the apertures formed along the brush head;
- FIG. 2 is a side elevational view of the hairbrush depicted in FIG. 1 ;
- FIG. 3 is an enlarged elevational view showing one construction of the outer bristles of the hairbrush of the invention.
- FIG. 4 is also an enlarged elevational view showing a second construction of the outer bristles of the inventive hairbrush
- FIG. 5 is a front elevational view of the cover used for closing the apertures formed on the head of the inventive hairbrush
- FIG. 6 is a side elevational view of the cover depicted in FIG. 5 ;
- FIG. 7 is a front elevational view of the hairbrush of the invention, and depicting the cover of FIG. 1 in a second position in order to open the apertures formed along the brush head;
- FIG. 8 is a side elevational view of the hairbrush depicted in FIG. 7 .
- FIG. 9 is a side elevational view of a second embodiment of the inventive hair brush.
- FIG. 10 is a rear elevational view of the second embodiment
- FIG. 11 is a front elevational view of the second embodiment
- FIG. 12 is a side perspective view of the second embodiment.
- FIG. 13 is an enlarged perspective view, partially cut away of the brush head of the second embodiment.
- FIG. 14 is an exploded perspective view of the second embodiment showing the various component parts.
- FIGS. 1-8 of the drawing there is depicted a particulate dispensing hairbrush with combination bristles denoted generally by reference 10 .
- the brush 10 may be formed of any suitable lightweight material, preferably a plastic, with polypropylene being useable by example.
- the brush 10 may be formed of a single-piece, molded body 12 or of multiple pieces joined together by adhesive, double shot molding, heat or sonic welding, etc.
- the body 12 includes a handle 14 with elongated shaft 16 extending from a first outer end 18 to a second end 20 .
- An aperture 22 may be formed in the shaft 16 adjacent the first end 18 to provide a convenient means for supporting the brush on a hook or other surface when not in use.
- the shaft 16 is provided in a convenient hand grip size and may optionally be provided with ergonomic surfaces 24 , such as soft, flexible ribs, which extend along some or substantially all of the exterior surface of the shaft 16 .
- the body 12 of the brush 10 also includes a head 30 which may be integrally joined to the shaft 16 .
- the head 30 has a generally cubical, hollow shape, with the illustrated rectangular shape being by way of example only.
- the head 30 has a first end 32 and an opposed second end 34 .
- the second end 34 of the head 30 is joined to the second end 20 of the shaft 16 of the handle 14 by a connector 36 .
- the head 30 is formed with a hollow interior chamber or reservoir 38 which opens to an aperture 40 at the first end 32 of the head 30 .
- the aperture 40 is releasably closable by a cap 42 .
- the cap 42 may be affixed to the first end 32 of the head 30 by a snap-on, friction fit, a threaded connection, etc.
- Dispensable materials i.e., particulate solids, such as powder, or even fluid materials, may be introduced into the reservoir 38 in the head 30 through the aperture 40 .
- At least one aperture is formed in one major surface of the head 30 .
- the apertures 44 open to the reservoir 38 to allow transfer or migration of the material contained within the reservoir 38 through the apertures 44 and onto the bristles mounted on the head 30 as described hereafter for dispensing to human or pet hair.
- a cover 50 is in the form of an elongated, generally flat rod having a first end 52 and an opposed second end 54 .
- the second end 54 is enlarged, such as by a bent flange 58 , to provide a finger engageable edge for moving the cover 50 between a first position shown in FIG. 1 wherein apertures 56 , which are provided in substantially the same size and the same number as the aperture(s) 44 in the head 30 , are spaced from the apertures 44 in the head 30 by solid portions of the cover 50 to close off the apertures 44 to the transfer of the material within the reservoir 38 to the bristles on the head 30 and a second position, shown in FIGS. 7 and 8 , wherein the apertures 56 in the cover 50 are aligned with the apertures 44 and the head 30 allowing dispending of material from the reservoir 38 to the brush bristles.
- the cover 50 may be mounted interiorally or exteriorally on the major surface 31 of the head 30 and may slide within a groove formed in the major surface 31 of the head 30 .
- the groove 60 slidably captures the cover 50 in the head 30 .
- a plurality of bristles are mounted on the major surface 31 of the head 30 .
- a first group of bristles 70 are fixedly mounted on the major surface 31 of the head 30 by suitable mounting means, such as molding in the major surface 31 , adhesive, staples, etc.
- the first group of bristles 70 may be formed of soft, densely arranged, boars hair bristles.
- a second group of bristles 74 are arranged about substantially the entire outer periphery of the first group of bristles 70 , as shown in FIGS. 1 and 7 .
- the bristles 74 forming the second outer peripheral group of bristles generally have a more rigid construction that the softer bristles 70 in the first group of bristles 70 .
- the outer peripheral bristles 74 which are illustrated as being disposed only along the two longitudinal sides of the inner bristles 70 , may comprise individual, flexible nylon or polypropylene bristles which are joined by means of molding, hooking or other fastening means such as molding to the major surface 31 of the head 30 .
- the bristles 74 as shown in detail in FIG. 4 , have a shaft 76 , a spherical ball-shaped end 78 , and an attachment end 80 which is illustrated by example only as being in the form of a bent hook for mounting in the first major surface 31 of the head 30 .
- FIG. 3 depicts an alternate construction for the outer bristles in which the outer bristles are formed of clumps or groups 84 of a plurality of flexible plastic, such as nylon, bristles.
- the bristles 84 are flexible, but more rigid than the inner disposed, softer bristles 70 .
- the outer bristles may also be formed of metal, joined at one end to the head 30 for used with brushing pet undercoats.
- the height of the inner bristles 70 may be of the same height as the outer peripheral bristles 74 .
- the outer peripheral bristles 74 may also be provided in different heights, one set of which may be of the same height as the inner bristle 70 or both sets may be shorter in height than the overall height of the inner bristles 70 .
- the brush 10 may be used as a conventional brush on human or pet hair or undercoats when the cover 50 is in the first closed position shown in FIGS. 1 and 2 .
- the more rigid outer peripheral bristles 74 , 84 , etc. gently stroke hair, and, in particular, braids, without detangling or untwisting the braids.
- the outer peripheral bristles separate and detangle the hair as the brush 10 is drawn through the hair in a sideways direction of the brush 10 . That is, the brush 10 is urged through human or pet hair or pet undercoats in a sideways motion from left to right or right to left in the brush orientation shown in FIG. 1 .
- the cover 50 When it is desired to dispense the particulate or other material stored in the reservoir 38 , the cover 50 is urged to the second open position. While the brush 10 is moved through the human or pet hair or pet undercoat, gravity causes the particulate material or other material stored within the reservoir 38 in to migrate or transfer from the reservoir 38 to the soft, inner bristles 70 and then onto the human or pet hair.
- the brush 10 may be vibrated by shaking the brush during each brushing stroke to promote or enhance migration of material from the reservoir 38 to the inner bristles 70 .
- a vibratory means such as a small battery powered motor, may be mounted in the brush 10 , such as in the handle 14 , to provide vibration of the head 30 during brush strokes.
- the brush 10 may be constructed without the slidable cover 50 .
- the apertures 44 in head 30 remain open at all times. Due to the slightly clinging nature of powder or other particulate material typically applied to human hair, or pet hair or fur, while a small amount of the particulate material may migrate from the interior reservoir 38 through the apertures 44 onto the bristles 70 when the major surface 31 is oriented in a downward facing position, substantial transfer of the particulate material is achieved during a brush stroke by means of vibration, i.e., by either manual shaking of the brush or a motor aided vibration as described above.
- FIGS. 9-14 of the drawings there is depicted a second embodiment of a particulate dispensing hairbrush with combination bristles denoted generally by reference 110 .
- Brush 110 may also be formed of any suitable lightweight material, preferably a plastic, with polypropylene being useable by example. Brush 110 may be formed of a single-piece, molded body 112 or of multiple pieces joined together by adhesive, double shot molding, heat or sonic welding, etc.
- Body 112 includes a handle 114 with an aperture 122 which may be formed in handle 114 adjacent to one end to provide a convenient means for supporting the brush on a hook or other surface when not in use.
- Handle 114 is provided with an over-grip having an ergonomic surface 124 , such as soft, flexible ribs, which extend along some or substantially all of the exterior surface of handle 114 .
- Body 112 of the brush 110 also includes a head 130 which is joined to handle 114 .
- Head 130 includes a top 144 and a bottom 146 and has a first end and an opposed second end. The second end of the head 130 is joined to the other end of handle 114 by means of fingers 148 a , 148 b extending from top 144 and bottom 146 , respectively.
- Head 130 is formed with a hollow interior chamber or reservoir 138 (defined by reservoir top 154 and reservoir bottom 156 ) which opens to an access aperture at the end of the head 130 (see FIGS. 13 and 14 ).
- the aperture is releasably closable by a cap 142 .
- dispensable materials i.e., particulate solids, such as powder, or even fluid materials, may be introduced into reservoir 138 in head 130 through the aperture.
- Apertures 151 are shown in FIG. 11 along one surface of the head 130 . Apertures 151 open to reservoir 138 to allow transfer or migration of the material contained within the reservoir 138 through the apertures 151 and onto the bristles mounted on the head 130 , as described hereafter, for dispensing to human or pet hair.
- a plurality of bristles are mounted along said one surface of the head 130 .
- a first group of bristles (not shown) may be fixedly mounted along the surface of head 130 at location 161 comprising soft, densely arranged, boar or horse hair bristles.
- a second group of bristles 141 are arranged about substantially the entire outer periphery of location 161 . Bristles 141 forming the second outer peripheral group of bristles are typically made of a plastic material and generally have a more rigid construction than the softer bristles of the first group.
- brush 110 may be used as a conventional brush on human or pet hair or undercoats.
- a load dial 131 is provided along the neck region of head 130 in order to turn a shaft 133 to which the load dial is connected, which subsequently turns a load dial fin 135 connected to shaft 133 and located within brush head 130 .
- fin 135 turns or moves, it engages and depresses an internal piston/plunger unit 137 .
- Piston/plunger unit 137 includes a plurality of pistons 139 and urges the material held in reservoir 138 through apertures 151 where the material is ultimately trapped by the soft, densely arranged horse or boar hair bristles for subsequent transfer. Piston/plunger unit 137 then springs back into its original position (by means of springs 159 ) so that it is ready for additional dispensing of said material.
- brush 110 When it is desired to dispense the particulate or other material stored in the reservoir 138 , brush 110 is moved through the human or pet hair or pet undercoat, with gravity causing the particulate or other material stored within reservoir 138 to migrate or transfer from reservoir 138 to the brush and then onto the human or pet hair.
Abstract
A brush having a head with a reservoir formed therein and at least one aperture formed in the head for opening the reservoir to the exterior of the head is provided. The inventive brush also includes a plurality of bristles mounted on the head for transferring material dispensed from the reservoir through the at least one aperture in the head as the brush is drawn through human or animal hair. The inventive brush includes a refill aperture formed in the head and a cap releasably engageable with the refill aperture. The brush may also include a cover movably mounted on the head for closing an aperture in the head with the cover movable between a first position for closing the aperture, and a second position for opening the aperture.
Description
- This application claims priority to Provisional Application No. 60/871,535, filed Dec. 22, 2006 and incorporated herein by reference.
- This invention relates to a brush and a combination of bristles secured to the base.
- Various hair care utensils have been devised for grooming, cleaning, treating, medicating and otherwise taking care of human or pet hair, including utensils such as combs and brushes.
- Other hair grooming utensils include various spraying devices, such as manual pump sprays, pressurized aerosol containers, etc. These utensils are employed for applying hair coloring, cleansing solutions, medicinal compositions to treat various ailments, etc.
- Conventional brushes have a plurality of bristles arranged in various 2-dimensional patterns. While these brushes are effective for hair grooming, they cannot apply significant quantities of a liquid or other materials. Conventional brushes are also less than desirable for applying medicinal or other treatment compositions to hair and scalp. Moreover, most conventional brushes include a plurality of bristles of the same flexibility and stiffness. This is less than advantageous since transferring a particulate material to hair and scalp requires stiff bristles to part and separate the hair, and soft bristles to capture and deposit a particulate material to the hair and scalp.
- Accordingly, it would be desirable to provide a brush for stroking hair and collecting and depositing a particulate material on hair and scalp. It is also desirable to have a brush that is capable of applying medicine, cleaning solutions and other treatment material to the hair, skin or scalp, as the brush is drawn through the hair.
- Generally speaking, and in accordance with the invention, a brush having a head with a reservoir formed therein and at least one aperture formed in the head for opening the reservoir to the exterior of the head is provided. The inventive brush also includes a plurality of bristles mounted on the head for transferring material dispensed from the reservoir through the at least one aperture in the head as the brush is drawn through human or animal hair.
- In particular, the inventive brush includes a fill and/or refill aperture formed in the head and a cap releasably engageable with the refill aperture. The brush may also include a cover movably mounted on the head for closing an aperture in the head with the cover movable between a first position for closing the aperture, and a second position for opening the aperture.
- In accordance with the invention, the inventive brush includes a plurality of soft flexible bristles mounted along the head and surrounding the at least one aperture. These bristles are suitable for receiving materials that are dispensed through at least one aperture. In addition, the brush of the invention preferably includes a second group of stiffer, more rigid bristles disposed about the soft flexible bristles. In one form, the inner disposed bristles protrude beyond the height of the outer bristles.
- In a further embodiment, the inventive brush may include a vibration mechanism for vibrating the head in order to enhance migration of material from the reservoir to the bristles during use of the brush.
- Accordingly, it is an object of the invention to provide an improved particulate dispensing hairbrush.
- Yet another object of the invention is to provide an improved hairbrush having bristles of two or more different types.
- Yet a further object of the invention is to provide an improved hair brush that is capable of applying medicine, cleaning solutions, powders and other treatment to the hair, the skin or scalp, as the brush is being drawn through the hair.
- Still other objects and advantages of the invention will, in part, be obvious and will, in part, be apparent from the following description.
- For a fuller understanding of the invention, reference is made to the following description, taken in connection with the accompanying drawings, in which:
-
FIG. 1 is a front elevational view of the hairbrush of the invention and depicting the movable cover mounted on the brush head and disposed in a first position for closing the apertures formed along the brush head; -
FIG. 2 is a side elevational view of the hairbrush depicted inFIG. 1 ; -
FIG. 3 is an enlarged elevational view showing one construction of the outer bristles of the hairbrush of the invention; -
FIG. 4 is also an enlarged elevational view showing a second construction of the outer bristles of the inventive hairbrush; -
FIG. 5 is a front elevational view of the cover used for closing the apertures formed on the head of the inventive hairbrush; -
FIG. 6 is a side elevational view of the cover depicted inFIG. 5 ; -
FIG. 7 is a front elevational view of the hairbrush of the invention, and depicting the cover ofFIG. 1 in a second position in order to open the apertures formed along the brush head; and -
FIG. 8 is a side elevational view of the hairbrush depicted inFIG. 7 . -
FIG. 9 is a side elevational view of a second embodiment of the inventive hair brush; -
FIG. 10 is a rear elevational view of the second embodiment; -
FIG. 11 is a front elevational view of the second embodiment; -
FIG. 12 is a side perspective view of the second embodiment; and -
FIG. 13 is an enlarged perspective view, partially cut away of the brush head of the second embodiment; and -
FIG. 14 is an exploded perspective view of the second embodiment showing the various component parts. - Referring to
FIGS. 1-8 of the drawing, there is depicted a particulate dispensing hairbrush with combination bristles denoted generally byreference 10. - The
brush 10 may be formed of any suitable lightweight material, preferably a plastic, with polypropylene being useable by example. Thebrush 10 may be formed of a single-piece, moldedbody 12 or of multiple pieces joined together by adhesive, double shot molding, heat or sonic welding, etc. - By way of example only, the
body 12 includes ahandle 14 withelongated shaft 16 extending from a firstouter end 18 to asecond end 20. An aperture 22 may be formed in theshaft 16 adjacent thefirst end 18 to provide a convenient means for supporting the brush on a hook or other surface when not in use. - The
shaft 16 is provided in a convenient hand grip size and may optionally be provided withergonomic surfaces 24, such as soft, flexible ribs, which extend along some or substantially all of the exterior surface of theshaft 16. - The
body 12 of thebrush 10 also includes ahead 30 which may be integrally joined to theshaft 16. Thehead 30 has a generally cubical, hollow shape, with the illustrated rectangular shape being by way of example only. Thehead 30 has afirst end 32 and an opposedsecond end 34. Thesecond end 34 of thehead 30 is joined to thesecond end 20 of theshaft 16 of thehandle 14 by aconnector 36. - The
head 30 is formed with a hollow interior chamber orreservoir 38 which opens to anaperture 40 at thefirst end 32 of thehead 30. Theaperture 40 is releasably closable by acap 42. - The
cap 42 may be affixed to thefirst end 32 of thehead 30 by a snap-on, friction fit, a threaded connection, etc. - Dispensable materials, i.e., particulate solids, such as powder, or even fluid materials, may be introduced into the
reservoir 38 in thehead 30 through theaperture 40. - At least one aperture, with two pairs of spaced
apertures 44 being shown by way of example only, are formed in one major surface of thehead 30. Theapertures 44 open to thereservoir 38 to allow transfer or migration of the material contained within thereservoir 38 through theapertures 44 and onto the bristles mounted on thehead 30 as described hereafter for dispensing to human or pet hair. - A
cover 50 is in the form of an elongated, generally flat rod having afirst end 52 and an opposedsecond end 54. Thesecond end 54 is enlarged, such as by abent flange 58, to provide a finger engageable edge for moving thecover 50 between a first position shown inFIG. 1 whereinapertures 56, which are provided in substantially the same size and the same number as the aperture(s) 44 in thehead 30, are spaced from theapertures 44 in thehead 30 by solid portions of thecover 50 to close off theapertures 44 to the transfer of the material within thereservoir 38 to the bristles on thehead 30 and a second position, shown inFIGS. 7 and 8 , wherein theapertures 56 in thecover 50 are aligned with theapertures 44 and thehead 30 allowing dispending of material from thereservoir 38 to the brush bristles. - The
cover 50 may be mounted interiorally or exteriorally on themajor surface 31 of thehead 30 and may slide within a groove formed in themajor surface 31 of thehead 30. Thegroove 60 slidably captures thecover 50 in thehead 30. - A plurality of bristles are mounted on the
major surface 31 of thehead 30. Although all of the bristles can be of the same type of material and substantially the same height, by way of example only, a first group ofbristles 70 are fixedly mounted on themajor surface 31 of thehead 30 by suitable mounting means, such as molding in themajor surface 31, adhesive, staples, etc. The first group ofbristles 70 may be formed of soft, densely arranged, boars hair bristles. A second group ofbristles 74 are arranged about substantially the entire outer periphery of the first group ofbristles 70, as shown inFIGS. 1 and 7 . Thebristles 74 forming the second outer peripheral group of bristles generally have a more rigid construction that the softer bristles 70 in the first group of bristles 70. - The outer peripheral bristles 74, which are illustrated as being disposed only along the two longitudinal sides of the
inner bristles 70, may comprise individual, flexible nylon or polypropylene bristles which are joined by means of molding, hooking or other fastening means such as molding to themajor surface 31 of thehead 30. Thebristles 74, as shown in detail inFIG. 4 , have ashaft 76, a spherical ball-shapedend 78, and anattachment end 80 which is illustrated by example only as being in the form of a bent hook for mounting in the firstmajor surface 31 of thehead 30. -
FIG. 3 depicts an alternate construction for the outer bristles in which the outer bristles are formed of clumps orgroups 84 of a plurality of flexible plastic, such as nylon, bristles. Thebristles 84 are flexible, but more rigid than the inner disposed, softer bristles 70. - Although not shown, the outer bristles may also be formed of metal, joined at one end to the
head 30 for used with brushing pet undercoats. The height of theinner bristles 70 may be of the same height as the outer peripheral bristles 74. As shown inFIGS. 2 and 8 , the outerperipheral bristles 74 may also be provided in different heights, one set of which may be of the same height as the inner bristle 70 or both sets may be shorter in height than the overall height of the inner bristles 70. - In use, the
brush 10 may be used as a conventional brush on human or pet hair or undercoats when thecover 50 is in the first closed position shown inFIGS. 1 and 2 . The more rigid outerperipheral bristles brush 10 is drawn through the hair in a sideways direction of thebrush 10. That is, thebrush 10 is urged through human or pet hair or pet undercoats in a sideways motion from left to right or right to left in the brush orientation shown inFIG. 1 . - When it is desired to dispense the particulate or other material stored in the
reservoir 38, thecover 50 is urged to the second open position. While thebrush 10 is moved through the human or pet hair or pet undercoat, gravity causes the particulate material or other material stored within thereservoir 38 in to migrate or transfer from thereservoir 38 to the soft,inner bristles 70 and then onto the human or pet hair. - The
brush 10 may be vibrated by shaking the brush during each brushing stroke to promote or enhance migration of material from thereservoir 38 to the inner bristles 70. Alternately, a vibratory means, such as a small battery powered motor, may be mounted in thebrush 10, such as in thehandle 14, to provide vibration of thehead 30 during brush strokes. - It is also contemplated that the
brush 10 may be constructed without theslidable cover 50. In this aspect, theapertures 44 inhead 30 remain open at all times. Due to the slightly clinging nature of powder or other particulate material typically applied to human hair, or pet hair or fur, while a small amount of the particulate material may migrate from theinterior reservoir 38 through theapertures 44 onto thebristles 70 when themajor surface 31 is oriented in a downward facing position, substantial transfer of the particulate material is achieved during a brush stroke by means of vibration, i.e., by either manual shaking of the brush or a motor aided vibration as described above. - Referring to
FIGS. 9-14 of the drawings, there is depicted a second embodiment of a particulate dispensing hairbrush with combination bristles denoted generally byreference 110. -
Brush 110 may also be formed of any suitable lightweight material, preferably a plastic, with polypropylene being useable by example.Brush 110 may be formed of a single-piece, molded body 112 or of multiple pieces joined together by adhesive, double shot molding, heat or sonic welding, etc. - Body 112 includes a
handle 114 with anaperture 122 which may be formed inhandle 114 adjacent to one end to provide a convenient means for supporting the brush on a hook or other surface when not in use. - Handle 114 is provided with an over-grip having an
ergonomic surface 124, such as soft, flexible ribs, which extend along some or substantially all of the exterior surface ofhandle 114. - Body 112 of the
brush 110 also includes ahead 130 which is joined to handle 114.Head 130 includes a top 144 and a bottom 146 and has a first end and an opposed second end. The second end of thehead 130 is joined to the other end ofhandle 114 by means offingers -
Head 130 is formed with a hollow interior chamber or reservoir 138 (defined byreservoir top 154 and reservoir bottom 156) which opens to an access aperture at the end of the head 130 (seeFIGS. 13 and 14 ). The aperture is releasably closable by acap 142. - As in the first embodiment, dispensable materials, i.e., particulate solids, such as powder, or even fluid materials, may be introduced into
reservoir 138 inhead 130 through the aperture. -
Apertures 151 are shown inFIG. 11 along one surface of thehead 130.Apertures 151 open toreservoir 138 to allow transfer or migration of the material contained within thereservoir 138 through theapertures 151 and onto the bristles mounted on thehead 130, as described hereafter, for dispensing to human or pet hair. - A plurality of bristles are mounted along said one surface of the
head 130. Particularly, a first group of bristles (not shown) may be fixedly mounted along the surface ofhead 130 atlocation 161 comprising soft, densely arranged, boar or horse hair bristles. A second group ofbristles 141 are arranged about substantially the entire outer periphery oflocation 161.Bristles 141 forming the second outer peripheral group of bristles are typically made of a plastic material and generally have a more rigid construction than the softer bristles of the first group. - In use,
brush 110 may be used as a conventional brush on human or pet hair or undercoats. As shown inFIGS. 13 and 14 , aload dial 131 is provided along the neck region ofhead 130 in order to turn ashaft 133 to which the load dial is connected, which subsequently turns aload dial fin 135 connected toshaft 133 and located withinbrush head 130. Whenfin 135 turns or moves, it engages and depresses an internal piston/plunger unit 137. Piston/plunger unit 137 includes a plurality ofpistons 139 and urges the material held inreservoir 138 throughapertures 151 where the material is ultimately trapped by the soft, densely arranged horse or boar hair bristles for subsequent transfer. Piston/plunger unit 137 then springs back into its original position (by means of springs 159) so that it is ready for additional dispensing of said material. - When it is desired to dispense the particulate or other material stored in the
reservoir 138,brush 110 is moved through the human or pet hair or pet undercoat, with gravity causing the particulate or other material stored withinreservoir 138 to migrate or transfer fromreservoir 138 to the brush and then onto the human or pet hair.
Claims (24)
1. A brush for dispensing material, the brush comprising:
(a) a body having a handle and a head defining a brushing surface;
(b) a reservoir for containing said material formed within the head; and at least one aperture formed along said brushing surface of the head and opening the reservoir to the exterior of the head;
(c) a cover movably relative to the head for selectively closing the at least one aperture, the cover movable between a first position for closing said at least one aperture and a second position for opening the at least one aperture;
(d) a plurality of soft, inner disposed flexible bristles mounted on the head and depending from said surface, said inner bristles substantially surrounding the at least one aperture in the head for receiving material dispensed from the reservoir through the at least one aperture and transferring said material onto another surface as the brush is selectively engaged with the other surface; and
(e) a plurality of stiffer outer disposed bristles mounted on the head and depending from said surface, said outer bristles disposed about at least a portion of the outer periphery of said plurality of soft, inner disposed bristles.
2. The brush of claim 1 , wherein particulate material is disposed within the reservoir.
3. The brush of claim 1 , further comprising:
a refill aperture formed in the head; and
a cap releasable engageable with the refill aperture.
4. (canceled)
5. (canceled)
6. (canceled)
7. (canceled)
8. The brush of claim 1 , wherein the soft bristles are formed of boars hair or horse hair.
9. (canceled)
10. The brush of claim 1 , wherein the inner disposed bristles protrude beyond the height of at least some of the outer disposed bristles.
11. The brush of claim 1 , wherein the outer disposed bristles are formed of a rigid flexible material.
12. The brush of claim 11 , wherein the outer disposed bristles have an enlarged spherical shaped end.
13. The brush of claim 1 , further comprising:
vibration means, carried in the brush, for vibrating the head to enhance migration of the material from the reservoir to the bristles during use of the brush.
14. The brush of claim 1 , wherein said cover has a finger engageable surface to facilitate moving said cover between said first and second positions.
15. The brush of claim 1 , wherein said cover includes at least one opening which is in corresponding alignment with said at least one aperture when said cover is in said second position.
16. The brush of claim 1 , wherein said cover is slidable within a groove formed in said head surface to enable movement between said first and second positions.
17. The brush of claim 1 , wherein the outer disposed bristles are selected from the group consisting of nylon, polypropylene and polyethylene.
18. The brush of claim 1 , wherein the outer disposed bristles are mounted on the brush head by means of one of molding and hooking.
19. The brush of claim 1 , wherein the outer disposed bristles are in the form of clumps substantially surrounding an aperture.
20. The brush of claim 10 , wherein the height of all of the inner disposed bristles is substantially the same.
21. The brush of claim 20 , wherein some of the outer disposed bristles have a height substantially the same as that of the inner disposed bristles and wherein the remainder of said outer disposed bristles have a height that is substantially less than that of said inner disposed bristles.
22. The brush of claim 1 , wherein said cover comprises an elongated rod element having at least one opening which is aligned with said at least one aperture of said head only when said cover is in said second position.
23. The brush of claim 1 , wherein said cover is mounted interiorally of said brushing surface.
24. The brush of claim 1 , wherein said cover is mounted exteriorally of said brushing surface.
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US11/926,667 US20080149124A1 (en) | 2006-12-22 | 2007-10-29 | Particulate material dispensing hairbrush with combination bristles |
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US11/926,667 US20080149124A1 (en) | 2006-12-22 | 2007-10-29 | Particulate material dispensing hairbrush with combination bristles |
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US8883717B2 (en) | 2012-03-30 | 2014-11-11 | Artificial Cell Technologies, Inc. | Antigenic compositions and methods |
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Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1722686A (en) * | 1928-06-12 | 1929-07-30 | Soss Mark | Fountain brush |
US2823401A (en) * | 1954-01-15 | 1958-02-18 | O'higgins Michael | Tooth brush |
US3133546A (en) * | 1961-05-24 | 1964-05-19 | Valden Company | Combination comb and brush |
US3180342A (en) * | 1962-01-26 | 1965-04-27 | Dietsche Erich | Brush comb |
US3597097A (en) * | 1969-05-21 | 1971-08-03 | Louis T Kellis | Dispensing brush with housing vavle closure |
US3597098A (en) * | 1969-05-21 | 1971-08-03 | Louis T Kellis | Squeeze brush with rotary dispenser |
US4057901A (en) * | 1975-08-04 | 1977-11-15 | Gary Bloem | Wet comb |
US4902154A (en) * | 1986-07-30 | 1990-02-20 | Valenza Michael A | Dispensing brush with barb means to rupture material packet |
US5301695A (en) * | 1992-10-19 | 1994-04-12 | Wong Hilda C | Brush and method for hair treatment using bristle arrays of different densities and materials |
US5927290A (en) * | 1997-03-21 | 1999-07-27 | Thiruppathi; Devaraj | Liquid dispensing hair brush |
Family Cites Families (194)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US420516A (en) * | 1890-02-04 | Jean baptiste nadeau | ||
US562433A (en) * | 1896-06-23 | William b | ||
US3314941A (en) * | 1964-06-23 | 1967-04-18 | American Cyanamid Co | Novel substituted pyridodiazepins |
US4044724A (en) * | 1976-05-13 | 1977-08-30 | Hindes Limited | Grooming and dispensing brush head |
US4143982A (en) * | 1977-04-15 | 1979-03-13 | Cox Robert H | Dispensing brush |
US4213423A (en) * | 1978-05-01 | 1980-07-22 | Bryan Henry A | Powder dispenser |
ZA848968B (en) * | 1983-11-18 | 1986-06-25 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinolines and 1h-imidazo(4,5-c)quinolin-4-amines |
IL73534A (en) * | 1983-11-18 | 1990-12-23 | Riker Laboratories Inc | 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds |
US4944625A (en) * | 1988-10-21 | 1990-07-31 | Revlon, Inc. | Powder-applying brush |
US5238944A (en) * | 1988-12-15 | 1993-08-24 | Riker Laboratories, Inc. | Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine |
US5756747A (en) * | 1989-02-27 | 1998-05-26 | Riker Laboratories, Inc. | 1H-imidazo 4,5-c!quinolin-4-amines |
US4929624A (en) * | 1989-03-23 | 1990-05-29 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo(4,5-c)quinolin-4-amines |
US5037986A (en) * | 1989-03-23 | 1991-08-06 | Minnesota Mining And Manufacturing Company | Olefinic 1H-imidazo[4,5-c]quinolin-4-amines |
NZ232740A (en) | 1989-04-20 | 1992-06-25 | Riker Laboratories Inc | Solution for parenteral administration comprising a 1h-imidazo(4,5-c) quinolin-4-amine derivative, an acid and a tonicity adjuster |
US4988815A (en) * | 1989-10-26 | 1991-01-29 | Riker Laboratories, Inc. | 3-Amino or 3-nitro quinoline compounds which are intermediates in preparing 1H-imidazo[4,5-c]quinolines |
WO1992006093A1 (en) | 1990-10-05 | 1992-04-16 | Minnesota Mining And Manufacturing Company | Process for the preparation of imidazo[4,5-c]quinolin-4-amines |
US5175296A (en) | 1991-03-01 | 1992-12-29 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-c]quinolin-4-amines and processes for their preparation |
US5389640A (en) * | 1991-03-01 | 1995-02-14 | Minnesota Mining And Manufacturing Company | 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
US5268376A (en) | 1991-09-04 | 1993-12-07 | Minnesota Mining And Manufacturing Company | 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines |
US5266575A (en) | 1991-11-06 | 1993-11-30 | Minnesota Mining And Manufacturing Company | 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines |
IL105325A (en) * | 1992-04-16 | 1996-11-14 | Minnesota Mining & Mfg | Immunogen/vaccine adjuvant composition |
US5395937A (en) * | 1993-01-29 | 1995-03-07 | Minnesota Mining And Manufacturing Company | Process for preparing quinoline amines |
US5352784A (en) * | 1993-07-15 | 1994-10-04 | Minnesota Mining And Manufacturing Company | Fused cycloalkylimidazopyridines |
ATE195735T1 (en) * | 1993-07-15 | 2000-09-15 | Minnesota Mining & Mfg | IMIDAZO (4,5-C)PYRIDINE-4-AMINE |
US5365880A (en) * | 1994-04-14 | 1994-11-22 | South Judith M | Grooming and dispensing brush |
CA2560114A1 (en) * | 1994-07-15 | 1996-02-01 | The University Of Iowa Research Foundation | Immunomodulatory oligonucleotides |
US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US6239116B1 (en) * | 1994-07-15 | 2001-05-29 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
US5482936A (en) * | 1995-01-12 | 1996-01-09 | Minnesota Mining And Manufacturing Company | Imidazo[4,5-C]quinoline amines |
JPH09208584A (en) | 1996-01-29 | 1997-08-12 | Terumo Corp | Amide derivative, pharmaceutical preparation containing the same, and intermediate for synthesizing the same |
US5693811A (en) | 1996-06-21 | 1997-12-02 | Minnesota Mining And Manufacturing Company | Process for preparing tetrahdroimidazoquinolinamines |
US5741908A (en) * | 1996-06-21 | 1998-04-21 | Minnesota Mining And Manufacturing Company | Process for reparing imidazoquinolinamines |
EP0882727B9 (en) * | 1996-07-03 | 2005-06-15 | Sumitomo Pharmaceuticals Company, Limited | Novel purine derivatives |
US6387938B1 (en) * | 1996-07-05 | 2002-05-14 | Mochida Pharmaceutical Co., Ltd. | Benzimidazole derivatives |
EP0938315B9 (en) * | 1996-10-25 | 2008-02-20 | Minnesota Mining And Manufacturing Company | Immune response modifier compounds for treatment of th2 mediated and related diseases |
US5939090A (en) * | 1996-12-03 | 1999-08-17 | 3M Innovative Properties Company | Gel formulations for topical drug delivery |
US6069149A (en) * | 1997-01-09 | 2000-05-30 | Terumo Kabushiki Kaisha | Amide derivatives and intermediates for the synthesis thereof |
US6406705B1 (en) * | 1997-03-10 | 2002-06-18 | University Of Iowa Research Foundation | Use of nucleic acids containing unmethylated CpG dinucleotide as an adjuvant |
US6426334B1 (en) * | 1997-04-30 | 2002-07-30 | Hybridon, Inc. | Oligonucleotide mediated specific cytokine induction and reduction of tumor growth in a mammal |
US6303347B1 (en) * | 1997-05-08 | 2001-10-16 | Corixa Corporation | Aminoalkyl glucosaminide phosphate compounds and their use as adjuvants and immunoeffectors |
US6113918A (en) * | 1997-05-08 | 2000-09-05 | Ribi Immunochem Research, Inc. | Aminoalkyl glucosamine phosphate compounds and their use as adjuvants and immunoeffectors |
CA2301575C (en) * | 1997-05-20 | 2003-12-23 | Ottawa Civic Hospital Loeb Research Institute | Vectors and methods for immunization or therapeutic protocols |
JPH1180156A (en) | 1997-09-04 | 1999-03-26 | Hokuriku Seiyaku Co Ltd | 1-(substitutedaryl)alkyl-1h-imidazopyridin-4-amine derivative |
NZ504800A (en) | 1997-11-28 | 2001-10-26 | Sumitomo Pharma | 6-Amino-9-benzyl-8-hydroxy-purine derivatives and interferon inducers, antiviral agents, anticancer agents and therapeutic agents for immunologic diseases thereof |
UA67760C2 (en) * | 1997-12-11 | 2004-07-15 | Міннесота Майнінг Енд Мануфакчурінг Компані | Imidazonaphthyridines and use thereof to induce the biosynthesis of cytokines |
TW572758B (en) * | 1997-12-22 | 2004-01-21 | Sumitomo Pharma | Type 2 helper T cell-selective immune response inhibitors comprising purine derivatives |
JPH11222432A (en) | 1998-02-03 | 1999-08-17 | Terumo Corp | Preparation for external use containing amide derivative inducing interferon |
KR19990085365A (en) * | 1998-05-16 | 1999-12-06 | 허영섭 | Biodegradable polymer microspheres capable of continuously controlled controlled release and preparation method thereof |
SE9801923D0 (en) * | 1998-05-29 | 1998-05-29 | Independent Pharmaceutical Ab | Nicotine vaccine |
US6110929A (en) * | 1998-07-28 | 2000-08-29 | 3M Innovative Properties Company | Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof |
JP2000119271A (en) * | 1998-08-12 | 2000-04-25 | Hokuriku Seiyaku Co Ltd | 1h-imidazopyridine derivative |
US20020058674A1 (en) * | 1999-01-08 | 2002-05-16 | Hedenstrom John C. | Systems and methods for treating a mucosal surface |
CA2361936C (en) * | 1999-01-08 | 2009-06-16 | 3M Innovative Properties Company | Formulations comprising imiquimod or other immune response modifiers for treating mucosal conditions |
US6558951B1 (en) * | 1999-02-11 | 2003-05-06 | 3M Innovative Properties Company | Maturation of dendritic cells with immune response modifying compounds |
JP2000247884A (en) | 1999-03-01 | 2000-09-12 | Sumitomo Pharmaceut Co Ltd | Arachidonic acid-induced skin disease-treating agent |
US6546017B1 (en) | 1999-03-05 | 2003-04-08 | Cisco Technology, Inc. | Technique for supporting tiers of traffic priority levels in a packet-switched network |
US6257172B1 (en) * | 1999-03-19 | 2001-07-10 | Carl F. Leppanen | Powder-dispensing animal grooming brush |
US6573273B1 (en) * | 1999-06-10 | 2003-06-03 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
US6756382B2 (en) * | 1999-06-10 | 2004-06-29 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
US6451810B1 (en) * | 1999-06-10 | 2002-09-17 | 3M Innovative Properties Company | Amide substituted imidazoquinolines |
US6331539B1 (en) * | 1999-06-10 | 2001-12-18 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
US6541485B1 (en) * | 1999-06-10 | 2003-04-01 | 3M Innovative Properties Company | Urea substituted imidazoquinolines |
FR2794953B1 (en) * | 1999-06-18 | 2001-08-03 | Cosmogen | POWDER BRUSH FOR COSMETIC PURPOSES |
ES2233426T3 (en) | 1999-08-13 | 2005-06-16 | Hybridon, Inc. | MODULATION OF IMMUNE STIMULATION MEASURED BY CPG OF OLIGONUCLEOTIDE BY MODIFICATION OF THE POSITION OF NUCLEOSIDS. |
US6376689B1 (en) * | 1999-09-02 | 2002-04-23 | Cargill, Incorporated | Removal of gum and chlorophyll-type compounds from vegetable oils |
US6376669B1 (en) | 1999-11-05 | 2002-04-23 | 3M Innovative Properties Company | Dye labeled imidazoquinoline compounds |
AU2001245823A1 (en) | 2000-03-17 | 2001-10-03 | Corixa Corporation | Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors |
US6894060B2 (en) * | 2000-03-30 | 2005-05-17 | 3M Innovative Properties Company | Method for the treatment of dermal lesions caused by envenomation |
US6651132B1 (en) | 2000-07-17 | 2003-11-18 | Microsoft Corporation | System and method for emulating the operation of a translation look-aside buffer |
US20020055517A1 (en) * | 2000-09-15 | 2002-05-09 | 3M Innovative Properties Company | Methods for delaying recurrence of herpes virus symptoms |
JP2002145777A (en) | 2000-11-06 | 2002-05-22 | Sumitomo Pharmaceut Co Ltd | Therapeutic agent for arachidonic acid-induced dermatosis |
US6525064B1 (en) * | 2000-12-08 | 2003-02-25 | 3M Innovative Properties Company | Sulfonamido substituted imidazopyridines |
US6677348B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Aryl ether substituted imidazoquinolines |
CA2430206A1 (en) * | 2000-12-08 | 2002-06-13 | 3M Innovative Properties Company | Screening method for identifying compounds that selectively induce interferon alpha |
US6545017B1 (en) * | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Urea substituted imidazopyridines |
US20060142202A1 (en) * | 2000-12-08 | 2006-06-29 | 3M Innovative Properties Company | Compositions and methods for targeted delivery of immune response modifiers |
US6664264B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
US6545016B1 (en) * | 2000-12-08 | 2003-04-08 | 3M Innovative Properties Company | Amide substituted imidazopyridines |
US6667312B2 (en) | 2000-12-08 | 2003-12-23 | 3M Innovative Properties Company | Thioether substituted imidazoquinolines |
US6660735B2 (en) | 2000-12-08 | 2003-12-09 | 3M Innovative Properties Company | Urea substituted imidazoquinoline ethers |
US6664260B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Heterocyclic ether substituted imidazoquinolines |
US20020107262A1 (en) * | 2000-12-08 | 2002-08-08 | 3M Innovative Properties Company | Substituted imidazopyridines |
US6677347B2 (en) * | 2000-12-08 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamido ether substituted imidazoquinolines |
US6660747B2 (en) * | 2000-12-08 | 2003-12-09 | 3M Innovative Properties Company | Amido ether substituted imidazoquinolines |
US6664265B2 (en) | 2000-12-08 | 2003-12-16 | 3M Innovative Properties Company | Amido ether substituted imidazoquinolines |
UA74852C2 (en) | 2000-12-08 | 2006-02-15 | 3M Innovative Properties Co | Urea-substituted imidazoquinoline ethers |
CA2458876A1 (en) * | 2001-08-30 | 2003-03-13 | 3M Innovative Properties Company | Methods of maturing plasmacytoid dendritic cells using immune response modifier molecules |
CA2458533C (en) * | 2001-10-09 | 2011-01-04 | Tularik Inc. | Imidazole derivates as anti-inflammatory agents |
US20030139364A1 (en) * | 2001-10-12 | 2003-07-24 | University Of Iowa Research Foundation | Methods and products for enhancing immune responses using imidazoquinoline compounds |
US20040014779A1 (en) * | 2001-11-16 | 2004-01-22 | 3M Innovative Properties Company | Methods and compositions related to IRM compounds and toll-like recptor pathways |
CN1300165C (en) | 2001-11-27 | 2007-02-14 | 安那迪斯药品股份有限公司 | 3-b-d-ribofuranosylthiazolo [4,5-d] pyridimine nucleosides and uses thereof |
WO2004080430A2 (en) * | 2003-03-13 | 2004-09-23 | 3M Innovative Properties Company | Methods of improving skin quality |
EP1450804B9 (en) | 2001-11-29 | 2009-04-01 | 3M Innovative Properties Company | Pharmaceutical formulations comprising an immune response modifier |
US6677349B1 (en) * | 2001-12-21 | 2004-01-13 | 3M Innovative Properties Company | Sulfonamide and sulfamide substituted imidazoquinolines |
US6525028B1 (en) * | 2002-02-04 | 2003-02-25 | Corixa Corporation | Immunoeffector compounds |
EP1478327B1 (en) * | 2002-02-22 | 2015-04-29 | Meda AB | Method of reducing and treating uvb-induced immunosuppression |
US20030185835A1 (en) | 2002-03-19 | 2003-10-02 | Braun Ralph P. | Adjuvant for vaccines |
US7309182B2 (en) * | 2002-05-10 | 2007-12-18 | The Hartz Mountain Corporation | Liquid dispensing brush |
US20060026783A1 (en) * | 2002-05-10 | 2006-02-09 | Mckay William | Pet grooming tool with cotton swab bristles |
US6698626B2 (en) * | 2002-05-10 | 2004-03-02 | Mckay William D. | Lint remover and spray dispenser apparatus |
US7225950B2 (en) * | 2002-05-10 | 2007-06-05 | The Hartz Mountain Corporation | Lint roll/dispensable fluid container apparatus |
US20040052570A1 (en) * | 2002-05-10 | 2004-03-18 | Mckay William D. | Lint roller/brush assembly |
US7039982B1 (en) * | 2002-05-10 | 2006-05-09 | The Hartz Mountain Corporation | Lint roller/brush assembly |
GB0211649D0 (en) | 2002-05-21 | 2002-07-03 | Novartis Ag | Organic compounds |
EP1511746A2 (en) * | 2002-05-29 | 2005-03-09 | 3M Innovative Properties Company | Process for imidazo[4,5-c]pyridin-4-amines |
AU2003237386A1 (en) * | 2002-06-07 | 2003-12-22 | 3M Innovative Properties Company | Ether substituted imidazopyridines |
PT1543002E (en) * | 2002-07-23 | 2006-11-30 | Teva Gyogyszergyar Zartkoeruen | Preparation of 1h-imidazo 4,5-c |
ES2282691T3 (en) * | 2002-07-26 | 2007-10-16 | Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag | PREPARATION OF IH-IMIDAZO (4,5-C) QUINOLIN-4-AMINA THROUGH NEW INT ERMEDIOS 1H-IMIDAZO (4,5-C) QUINOLIN-4-CIANO AND 1H-IMIDAZO (4,5-C). |
ATE488246T1 (en) * | 2002-08-15 | 2010-12-15 | 3M Innovative Properties Co | IMMUNO-STIMULATORY COMPOSITIONS AND METHODS FOR STIMULATING AN IMMUNE RESPONSE |
JP2006503068A (en) | 2002-09-26 | 2006-01-26 | スリーエム イノベイティブ プロパティズ カンパニー | 1H-Imidazo dimer |
WO2004053057A2 (en) | 2002-12-11 | 2004-06-24 | 3M Innovative Properties Company | Gene expression systems and recombinant cell lines |
WO2004053452A2 (en) * | 2002-12-11 | 2004-06-24 | 3M Innovative Properties Company | Assays relating to toll-like receptor activity |
AU2003301052A1 (en) * | 2002-12-20 | 2004-07-22 | 3M Innovative Properties Company | Aryl / hetaryl substituted imidazoquinolines |
EP2572715A1 (en) * | 2002-12-30 | 2013-03-27 | 3M Innovative Properties Company | Immunostimulatory Combinations |
WO2004071459A2 (en) * | 2003-02-13 | 2004-08-26 | 3M Innovative Properties Company | Methods and compositions related to irm compounds and toll-like receptor 8 |
EP1599726A4 (en) * | 2003-02-27 | 2009-07-22 | 3M Innovative Properties Co | Selective modulation of tlr-mediated biological activity |
AU2004218349A1 (en) * | 2003-03-04 | 2004-09-16 | 3M Innovative Properties Company | Prophylactic treatment of UV-induced epidermal neoplasia |
US7163947B2 (en) * | 2003-03-07 | 2007-01-16 | 3M Innovative Properties Company | 1-Amino 1H-imidazoquinolines |
AU2004220534A1 (en) * | 2003-03-07 | 2004-09-23 | 3M Innovative Properties Company | 1-amino 1H-imidazoquinolines |
JP2006520245A (en) * | 2003-03-13 | 2006-09-07 | スリーエム イノベイティブ プロパティズ カンパニー | How to remove a tattoo |
JP2006523212A (en) * | 2003-03-13 | 2006-10-12 | スリーエム イノベイティブ プロパティズ カンパニー | Diagnosis method of skin lesion |
JP2006523452A (en) * | 2003-03-25 | 2006-10-19 | スリーエム イノベイティブ プロパティズ カンパニー | Selective activation of cellular activity mediated through a common Toll-like receptor |
US20040192585A1 (en) * | 2003-03-25 | 2004-09-30 | 3M Innovative Properties Company | Treatment for basal cell carcinoma |
US20060210588A1 (en) * | 2003-03-26 | 2006-09-21 | Cytos Biotechnology Ag | Hiv-peptide-carrier-conjugates |
EP1608369B1 (en) * | 2003-03-28 | 2013-06-26 | Novartis Vaccines and Diagnostics, Inc. | Use of organic compounds for immunopotentiation |
US20040265351A1 (en) * | 2003-04-10 | 2004-12-30 | Miller Richard L. | Methods and compositions for enhancing immune response |
CA2521682A1 (en) | 2003-04-10 | 2004-12-16 | 3M Innovative Properties Company | Delivery of immune response modifier compounds using metal-containing particulate support materials |
WO2004096144A2 (en) | 2003-04-28 | 2004-11-11 | 3M Innovative Properties Company | Compositions and methods for induction of opioid receptors |
US7731967B2 (en) * | 2003-04-30 | 2010-06-08 | Novartis Vaccines And Diagnostics, Inc. | Compositions for inducing immune responses |
DE10320450B4 (en) | 2003-05-08 | 2013-07-18 | Mtu Aero Engines Gmbh | sealing arrangement |
US20050106300A1 (en) | 2003-06-30 | 2005-05-19 | Purdue Research Foundation | Method for producing a material having an increased solubility in alcohol |
AR045260A1 (en) | 2003-08-12 | 2005-10-19 | 3M Innovative Properties Co | COMPOUNDS CONTAINING IMIDAZO-OXIMA REPLACED |
EP2939693A1 (en) | 2003-08-14 | 2015-11-04 | 3M Innovative Properties Company | Lipid-modified immune response modifiers |
WO2005018574A2 (en) * | 2003-08-25 | 2005-03-03 | 3M Innovative Properties Company | Immunostimulatory combinations and treatments |
AR045529A1 (en) | 2003-08-27 | 2005-11-02 | 3M Innovative Properties Co | IMIDAZOQUINOLINAS REPLACED WITH ARILOXI OR ARILALQUILENOXI GROUPS |
EA200600540A1 (en) * | 2003-09-05 | 2006-08-25 | Анадис Фармасьютикалз, Инк. | INTRODUCTION OF TLR7 LIGANDS AND THEIR TREATMENTS FOR THE TREATMENT OF HEPATITIS C VIRUS INFECTION |
CA2536530A1 (en) * | 2003-10-01 | 2005-04-14 | Taro Pharmaceuticals U.S.A., Inc. | Method of preparing 4-amino-1h-imidazo(4,5-c)quinolines and acid addition salts thereof |
CN1897948A (en) | 2003-10-03 | 2007-01-17 | 3M创新有限公司 | Alkoxy substituted imidazoquinolines |
US7544697B2 (en) * | 2003-10-03 | 2009-06-09 | Coley Pharmaceutical Group, Inc. | Pyrazolopyridines and analogs thereof |
SG149829A1 (en) * | 2003-10-03 | 2009-02-27 | 3M Innovative Properties Co | Pyrazolopyridines and analogs thereof |
ITMI20032121A1 (en) * | 2003-11-04 | 2005-05-05 | Dinamite Dipharma Spa In Forma Abbr Eviata Dipharm | PROCEDURE FOR THE PREPARATION OF IMIQUIMOD AND ITS INTERMEDIATES |
US8598192B2 (en) | 2003-11-14 | 2013-12-03 | 3M Innovative Properties Company | Hydroxylamine substituted imidazoquinolines |
EP1685129A4 (en) | 2003-11-14 | 2008-10-22 | 3M Innovative Properties Co | Oxime substituted imidazo ring compounds |
AR046845A1 (en) | 2003-11-21 | 2005-12-28 | Novartis Ag | DERIVATIVES OF 1H-IMIDAZO [4,5-C] QUINOLINE FOR THE TREATMENT OF PROTEIN-KINASE DEPENDENT DISEASES |
PL1687305T3 (en) | 2003-11-21 | 2008-12-31 | Novartis Ag | 1h-imidazoquinoline derivatives as protein kinase inhibitors |
JP4891088B2 (en) | 2003-11-25 | 2012-03-07 | スリーエム イノベイティブ プロパティズ カンパニー | Substituted imidazo ring systems and methods |
US8778963B2 (en) | 2003-11-25 | 2014-07-15 | 3M Innovative Properties Company | Hydroxylamine and oxime substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
CN1914203A (en) | 2003-12-04 | 2007-02-14 | 3M创新有限公司 | Sulfone substituted imidazo ring ethers |
US20090028874A1 (en) * | 2003-12-24 | 2009-01-29 | Leiden University Medical Center | Synthetic Protein as Tumor-Specific Vaccine |
US7888349B2 (en) | 2003-12-29 | 2011-02-15 | 3M Innovative Properties Company | Piperazine, [1,4]Diazepane, [1,4]Diazocane, and [1,5]Diazocane fused imidazo ring compounds |
JP2007517035A (en) | 2003-12-29 | 2007-06-28 | スリーエム イノベイティブ プロパティズ カンパニー | Arylalkenyl and arylalkynyl substituted imidazoquinolines |
US8735421B2 (en) | 2003-12-30 | 2014-05-27 | 3M Innovative Properties Company | Imidazoquinolinyl sulfonamides |
JP5064037B2 (en) | 2004-02-23 | 2012-10-31 | ジェネンテック, インコーポレイテッド | Heterocyclic self-destructive linkers and conjugates |
EP1730143A2 (en) | 2004-03-24 | 2006-12-13 | 3M Innovative Properties Company | Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines |
EP1735010A4 (en) * | 2004-04-09 | 2008-08-27 | 3M Innovative Properties Co | Methods, compositions, and preparations for delivery of immune response modifiers |
US20080015184A1 (en) | 2004-06-14 | 2008-01-17 | 3M Innovative Properties Company | Urea Substituted Imidazopyridines, Imidazoquinolines, and Imidazonaphthyridines |
WO2005123080A2 (en) | 2004-06-15 | 2005-12-29 | 3M Innovative Properties Company | Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines |
WO2006038923A2 (en) | 2004-06-18 | 2006-04-13 | 3M Innovative Properties Company | Aryl substituted imidazonaphthyridines |
WO2006009826A1 (en) | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines |
WO2006093514A2 (en) | 2004-06-18 | 2006-09-08 | 3M Innovative Properties Company | Aryl and arylalkylenyl substituted thiazoloquinolines and thiazolonaphthyridines |
EP1765348B1 (en) | 2004-06-18 | 2016-08-03 | 3M Innovative Properties Company | Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines |
WO2006009832A1 (en) | 2004-06-18 | 2006-01-26 | 3M Innovative Properties Company | Substituted imidazo ring systems and methods |
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-
2007
- 2007-08-06 US US11/834,355 patent/US20080149123A1/en not_active Abandoned
- 2007-10-29 US US11/926,667 patent/US20080149124A1/en not_active Abandoned
- 2007-12-20 WO PCT/US2007/088277 patent/WO2008079924A1/en active Application Filing
- 2007-12-20 EP EP07869593.9A patent/EP2125738B1/en active Active
- 2007-12-20 US US12/519,463 patent/US10005772B2/en active Active
-
2018
- 2018-06-25 US US16/016,933 patent/US10144735B2/en active Active
Patent Citations (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US1722686A (en) * | 1928-06-12 | 1929-07-30 | Soss Mark | Fountain brush |
US2823401A (en) * | 1954-01-15 | 1958-02-18 | O'higgins Michael | Tooth brush |
US3133546A (en) * | 1961-05-24 | 1964-05-19 | Valden Company | Combination comb and brush |
US3180342A (en) * | 1962-01-26 | 1965-04-27 | Dietsche Erich | Brush comb |
US3597097A (en) * | 1969-05-21 | 1971-08-03 | Louis T Kellis | Dispensing brush with housing vavle closure |
US3597098A (en) * | 1969-05-21 | 1971-08-03 | Louis T Kellis | Squeeze brush with rotary dispenser |
US4057901A (en) * | 1975-08-04 | 1977-11-15 | Gary Bloem | Wet comb |
US4902154A (en) * | 1986-07-30 | 1990-02-20 | Valenza Michael A | Dispensing brush with barb means to rupture material packet |
US5301695A (en) * | 1992-10-19 | 1994-04-12 | Wong Hilda C | Brush and method for hair treatment using bristle arrays of different densities and materials |
US5927290A (en) * | 1997-03-21 | 1999-07-27 | Thiruppathi; Devaraj | Liquid dispensing hair brush |
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US20110067644A1 (en) * | 2009-09-22 | 2011-03-24 | The Hartz Mountain Corporation | Pet grooming tool |
KR101073167B1 (en) * | 2009-11-30 | 2011-10-12 | 김선한 | Hair brush |
US8595885B1 (en) * | 2010-01-05 | 2013-12-03 | Ronald S. Weinstein | Pet hair and human hair grooming brush with two sets of different bristles |
US20110297101A1 (en) * | 2010-06-08 | 2011-12-08 | Products Of Tomorrow, Inc. | Massaging Pet Brush With Interchangeable Heads |
US9210994B2 (en) * | 2010-12-31 | 2015-12-15 | Goody Products, Inc. | Water removing hair brush |
US20140101879A1 (en) * | 2010-12-31 | 2014-04-17 | Roberta Celeste Brown | Water Removing Hair Brush |
USD785949S1 (en) | 2011-12-30 | 2017-05-09 | Goody Products, Inc. | Water removing hair brush |
US8869807B2 (en) * | 2012-08-28 | 2014-10-28 | Stephanie Ann Olson | Aperture brush with engaging product insert |
US20170367455A1 (en) * | 2014-12-12 | 2017-12-28 | Delta Research, S.A. | Combing device |
USD784705S1 (en) * | 2016-02-24 | 2017-04-25 | Thomas Kent York | Hair brush |
USD792711S1 (en) * | 2016-03-10 | 2017-07-25 | Gim-Hwa Enterprise Co., Ltd. | Hair brush |
US11324300B2 (en) * | 2017-06-06 | 2022-05-10 | Capillus Marketing Llc | Combing device |
US20190045918A1 (en) * | 2017-08-10 | 2019-02-14 | Scott Alan Przirembel | Liquid dispensing hair brush |
US11653751B2 (en) * | 2017-08-10 | 2023-05-23 | Scott Przirembel | Liquid dispensing hair brush |
US11259625B2 (en) * | 2018-09-21 | 2022-03-01 | Dawn N. Myers | Enhanced hair product application with concurrent styling |
US20220095778A1 (en) * | 2020-09-29 | 2022-03-31 | Robin Watts | Liquid Dispensing Hairbrush Apparatus |
Also Published As
Publication number | Publication date |
---|---|
EP2125738B1 (en) | 2020-01-22 |
EP2125738A1 (en) | 2009-12-02 |
US10144735B2 (en) | 2018-12-04 |
US10005772B2 (en) | 2018-06-26 |
US20100158928A1 (en) | 2010-06-24 |
EP2125738A4 (en) | 2010-12-29 |
US20180305357A1 (en) | 2018-10-25 |
US20080149123A1 (en) | 2008-06-26 |
WO2008079924A1 (en) | 2008-07-03 |
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Legal Events
Date | Code | Title | Description |
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STCB | Information on status: application discontinuation |
Free format text: ABANDONED -- FAILURE TO RESPOND TO AN OFFICE ACTION |