US20080249065A1 - Ophthalmic Pharmaceutical Compositions Based on Amino Acids and Sodium Hyaluronate - Google Patents
Ophthalmic Pharmaceutical Compositions Based on Amino Acids and Sodium Hyaluronate Download PDFInfo
- Publication number
- US20080249065A1 US20080249065A1 US12/091,481 US9148106A US2008249065A1 US 20080249065 A1 US20080249065 A1 US 20080249065A1 US 9148106 A US9148106 A US 9148106A US 2008249065 A1 US2008249065 A1 US 2008249065A1
- Authority
- US
- United States
- Prior art keywords
- ophthalmic pharmaceutical
- pharmaceutical composition
- patient
- proline
- leucine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/726—Glycosaminoglycans, i.e. mucopolysaccharides
- A61K31/728—Hyaluronic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/401—Proline; Derivatives thereof, e.g. captopril
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/04—Artificial tears; Irrigation solutions
Definitions
- the present invention relates to ophthalmic pharmaceutical compositions, based on amino acids and sodium hyaluronate, with a protective and regenerating action on the corneal epithelial cells.
- Dry eye syndrome is treated with eyedrops or gels (artificial tears) having a cleansing, lubricant and disinfecting action, which possess the chemico-physical characteristics of natural tears.
- treatment usually involves administering topical preparations (eyedrops, ointments or artificial tears) with an antibiotic and anti-inflammatory activity.
- the invention therefore relates to ophthalmic pharmaceutical compositions containing, as active ingredient, a combination of:
- compositions according to the invention contain glycine, L-proline and sodium hyaluronate, and possibly L-lysine in the form of hydrochloride and L-leucine.
- compositions according to the invention have a surprising effect as adjuvants: they aid regeneration of the epithelial microvilli and induce and accelerate corneal re-epithelialisation after eye surgery.
- compositions according to the invention will therefore be used to treat:
- compositions according to the invention will be applied to the eye 4-6 times a day, for a maximum of 3 months.
- compositions according to the invention will contain the various active ingredients within the following percentage ranges by weight:
- compositions according to the invention will contain the various active ingredients in the following percentages by weight:
- Sodium hyaluronate is added separately to 100 kg of purified water, and stirred until the component has completely dissolved.
- the two solutions are combined and made up to the final volume of 144 litres with purified water, checking that the pH value is between 6 and 7, and adjusting with citric acid or sodium bicarbonate if necessary.
- the solution is filtered through an 0.22 ⁇ m filter under sterile conditions and placed in a container.
- the protective and regenerative efficacy of the artificial tears according to the invention in reconstituting the corneal epithelium and stromal tissue in the case of pathological, traumatic, surgical, or parasurgical corneal lesions was investigated.
- Group B the post-operative re-epithelialisation time was shortened from the usual 4-6 days to 2-3 days, and the administration of artificial tears, even after re-epithelialisation was complete, proved to prevent the appearance of haze and the dry eye syndrome typical of the first few months after surgery.
Abstract
This invention relates to ophthalmic wound-healing pharmaceutical compositions based on amino acids and sodium hyaluronate.
Description
- The present invention relates to ophthalmic pharmaceutical compositions, based on amino acids and sodium hyaluronate, with a protective and regenerating action on the corneal epithelial cells.
- No cure for hypolacrimation (dry eye) has yet been found. Dry eye syndrome is treated with eyedrops or gels (artificial tears) having a cleansing, lubricant and disinfecting action, which possess the chemico-physical characteristics of natural tears.
- Artificial tears are fairly dense preparations, designed to remain in the eye at length and prevent rapid dilation.
- These products considerably reduce the quality of vision after administration, and do not perform any wound-healing action.
- Eye surgery designed to correct visual defects and remove cataracts is becoming increasingly common. These operations do not usually require stitches, but the wounds take some time to heal.
- No wound-healing agents exist which promote rapid healing of corneal ulcerations, wounds and lesions of post-operative, pathological, traumatic or parasurgical origin.
- Consequently, treatment usually involves administering topical preparations (eyedrops, ointments or artificial tears) with an antibiotic and anti-inflammatory activity.
- There is therefore a need for new preparations which perform a regenerating action at epithelial level, and promote corneal re-epithelialisation and rapid healing.
- It has now been found that the combination of some amino acids with sodium hyaluronate is particularly effective in promoting the process of reconstitution of the corneal epithelium and the stromal tissue in the case of pathological, traumatic, surgical or parasurgical corneal lesions.
- The invention therefore relates to ophthalmic pharmaceutical compositions containing, as active ingredient, a combination of:
- a) glycine and proline;
- b) sodium hyaluronate; and possibly
- c) lysine and leucine.
- More particularly, the compositions according to the invention contain glycine, L-proline and sodium hyaluronate, and possibly L-lysine in the form of hydrochloride and L-leucine.
- The compositions according to the invention have a surprising effect as adjuvants: they aid regeneration of the epithelial microvilli and induce and accelerate corneal re-epithelialisation after eye surgery.
- The compositions according to the invention will therefore be used to treat:
-
- slight, moderate or serious alterations of the tear film: the regeneration effect on the epithelial microvilli, which represent the fundamental substrate for effective restoration of the glycocalyx and consequently the tear film, drastically reduces the typical symptoms of dry eye.
- patients who undergo laser treatments (PRK): the reduction in post-operative re-epithelialisation time prevents the appearance of haze and dry eye syndrome which are typical of the first few months after surgery;
- relapsing and/or persistent corneal ulcers: the lasting re-epithelialisation effect prevents relapses and allows complete re-epithelialisation;
- cataract removal surgery, phacoemulsification: the rapid healing effect on the corneal tunnel significantly reduces the discomfort felt by the patient.
- The compositions according to the invention will be applied to the eye 4-6 times a day, for a maximum of 3 months.
- The compositions according to the invention will contain the various active ingredients within the following percentage ranges by weight:
-
- glycine 0.01 to 0.5%;
- L-proline: 0.09 to 0.06%;
- sodium hyaluronate: 0.5 to 0.1% and possibly
- L-lysine hydrochloride: 0.01 to 0.02%;
- L-leucine: 0.02 to 0.005%.
- According to a preferred aspect, the compositions according to the invention will contain the various active ingredients in the following percentages by weight:
-
- glycine: 0.1%
- L-proline: 0.075%;
- sodium hyaluronate: 0.3%;
- and possibly
-
- L-lysine hydrochloride: 0.014;
- L-leucine: 0.011%.
- The following is an example of a formulation according to the invention.
-
-
Eyedrop formulation Grams per INGREDIENTS unit dose Sodium hyaluronate 0.3000 L-Proline 0.0752 Glycine 0.1000 L-Lysine HCl 0.0140 L-Leucine 0.0108 Sodium chloride 0.9000 Distilled water to 100.0 mL - Preparation
- 30 kg of purified water is mixed with L-proline, glycine, lysine HCl, L-leucine and sodium chloride, and stirred until all the components have completely dissolved.
- Sodium hyaluronate is added separately to 100 kg of purified water, and stirred until the component has completely dissolved.
- The two solutions are combined and made up to the final volume of 144 litres with purified water, checking that the pH value is between 6 and 7, and adjusting with citric acid or sodium bicarbonate if necessary.
- Finally, the solution is filtered through an 0.22 μm filter under sterile conditions and placed in a container.
- Pharmacological Trial
- The protective and regenerative efficacy of the artificial tears according to the invention in reconstituting the corneal epithelium and stromal tissue in the case of pathological, traumatic, surgical, or parasurgical corneal lesions was investigated.
- 300 eyes of 200 patients were examined:
-
- 100 eyes of 50 patients suffering from slight, moderate or serious alterations of the tear film (Group A);
- 80 eyes of 40 patients who underwent laser surgery (PRK) (Group B);
- 20 eyes of 20 patients suffering from relapsing and/or persistent corneal ulcers (Group C);
- 84 eyes of 84 patients who underwent cataract removal surgery, namely phacoemulsification with IOL implantation (Group D).
- Cytomorphological study of the eye surface with confocal scanning electron microscopy (SEM) made it possible to analyse the histological modifications of the epithelial cells, and especially the microvilli. The Schimer test and BUT were used for the staging of the tear deficiency.
- Regeneration of the epithelial microvilli, the fundamental substrate for effective restoration of the glycocalyx, and consequently the tear film, was observed in Group A. The patients already perceived a noticeable benefit after 10 days of treatment, with a drastic reduction in the typical symptoms of dry eye.
- In Group B, the post-operative re-epithelialisation time was shortened from the usual 4-6 days to 2-3 days, and the administration of artificial tears, even after re-epithelialisation was complete, proved to prevent the appearance of haze and the dry eye syndrome typical of the first few months after surgery.
- In Group C, re-epithelialisation and stability of the epithelium were obtained, without relapses, and where the ulcer had been already present for several weeks, complete re-epithelialisation was achieved.
- Early healing of the corneal tunnel, with a definite reduction in the typical discomfort felt by the patient, was observed in Group D only a few days after the cataract operation.
Claims (19)
1-5. (canceled)
6. An ophthalmic pharmaceutical composition comprising as active ingredient a combination of:
a) glycine and proline; and
b) sodium hyaluronate.
7. The ophthalmic pharmaceutical composition of claim 6 , the composition further comprising as active ingredient:
c) lysine and leucine.
8. The ophthalmic pharmaceutical composition of claim 6 , wherein proline is L-proline, and wherein glycine, L-proline and sodium hyaluronate are comprised within the following percentage ranges by weight:
glycine 0.01 to 0.5%;
L-proline: 0.09 to 0.06%, and
sodium hyaluronate; 0.5 to 0.1%.
9. The ophthalmic pharmaceutical composition of claim 7 , wherein lysine is L-lysine, leucine is L-leucine and wherein L-lysine and L-leucine are comprised within the following percentage ranges by weight:
L-lysine hydrochloride: 0.01 to 0.02%; and
L-leucine: 0.02 to 0.005%.
10. The ophthalmic pharmaceutical composition of claim 6 , wherein proline is L-proline, and wherein glycine, L-proline and sodium hyaluronate have the following percentage ranges by weight:
glycine: 0.1%
L-proline: 0.075%; and
sodium hyaluronate: 0.3%.
11. The ophthalmic pharmaceutical composition of claim 7 , wherein lysine is L-lysine, leucine is L-leucine and wherein L-lysine and L-leucine have the following percentage ranges by weight:
L-lysine hydrochloride: 0.014%, and
L-leucine: 0.011%
12. The ophthalmic pharmaceutical composition of claim 6 , wherein the composition is in form of eyedrops, artificial tears, ointment or gel.
13. The ophthalmic pharmaceutical composition of claim 7 , wherein the composition is in form of eyedrops, artificial tears, ointment or gel.
14. The ophthalmic pharmaceutical composition of claim 8 , wherein the composition is in form of eyedrops, artificial tears, ointment or gel.
15. The ophthalmic pharmaceutical composition of claim 9 , wherein the composition is in form of eyedrops, artificial tears, ointment or gel
16. The ophthalmic pharmaceutical composition of claim 10 wherein the composition is in form of eyedrops, artificial tears, ointment or gel.
17. The ophthalmic pharmaceutical composition of claim 11 wherein the composition is in form of eyedrops, artificial tears, ointment or gel.
18. A method to treat a corneal ulceration in a patient, the method comprising
administering to the patient the ophthalmic pharmaceutical composition of claim 6 .
19. A method to treat a corneal ulceration in a patient, the method comprising
administering to the patient the ophthalmic pharmaceutical composition of claim 7 .
20. A method to treat a lesion of pathological, traumatic, surgical, or parasurgical origin in a patient, the method comprising
administering to the patient the ophthalmic pharmaceutical composition of claim 6 .
21. A method to treat a lesion of pathological, traumatic, surgical, or parasurgical origin in a patient, the method comprising
administering to the patient the ophthalmic pharmaceutical composition of claim 7 .
22. A method to treat symptoms of dry eye in a patient, the method comprising
administering to the patient the ophthalmic pharmaceutical composition of claim 6 .
23. A method to treat symptoms of dry eye in a patient, the method comprising
administering to the patient the ophthalmic pharmaceutical composition of claim 7 .
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITMI2005A002036 | 2005-10-26 | ||
IT002036A ITMI20052036A1 (en) | 2005-10-26 | 2005-10-26 | PHARMACEUTICAL COMPOSITIONS OPHTHALMIC BASED ON AMINO ACIDS AND SODIUM HYALURONATE |
PCT/EP2006/009967 WO2007048523A1 (en) | 2005-10-26 | 2006-10-16 | Ophthalmic pharmaceutical compositions based on amino acids and sodium hyaluronate |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/009967 A-371-Of-International WO2007048523A1 (en) | 2005-10-26 | 2006-10-16 | Ophthalmic pharmaceutical compositions based on amino acids and sodium hyaluronate |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/964,522 Continuation US8524687B2 (en) | 2005-10-26 | 2010-12-09 | Ophthalmic pharmaceutical compositions based on amino acids and sodium hyaluronate |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080249065A1 true US20080249065A1 (en) | 2008-10-09 |
Family
ID=37561156
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/091,481 Abandoned US20080249065A1 (en) | 2005-10-26 | 2006-10-16 | Ophthalmic Pharmaceutical Compositions Based on Amino Acids and Sodium Hyaluronate |
US12/964,522 Active 2026-11-02 US8524687B2 (en) | 2005-10-26 | 2010-12-09 | Ophthalmic pharmaceutical compositions based on amino acids and sodium hyaluronate |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/964,522 Active 2026-11-02 US8524687B2 (en) | 2005-10-26 | 2010-12-09 | Ophthalmic pharmaceutical compositions based on amino acids and sodium hyaluronate |
Country Status (11)
Country | Link |
---|---|
US (2) | US20080249065A1 (en) |
EP (1) | EP1940381B1 (en) |
JP (1) | JP5312946B2 (en) |
KR (1) | KR20080074107A (en) |
AT (1) | ATE451916T1 (en) |
CA (1) | CA2627215C (en) |
DE (1) | DE602006011196D1 (en) |
ES (1) | ES2335437T3 (en) |
IT (1) | ITMI20052036A1 (en) |
PL (1) | PL1940381T3 (en) |
WO (1) | WO2007048523A1 (en) |
Cited By (5)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080261915A1 (en) * | 2005-10-26 | 2008-10-23 | Solartium Llc | Wound-Healing Pharmaceutical Compositions in the Form of a Sterile Powder Based on Amino Acids and Sodium Hyaluronate |
US20080287392A1 (en) * | 2005-10-26 | 2008-11-20 | Solartium Llc | Wound-Healing Pharmaceutical Compositions in the Form of a Cream Based on Amino Acids and Sodium Hyaluronate |
US20110287064A1 (en) * | 2010-05-19 | 2011-11-24 | Heraeus Medical Gmbh | Antibiotic coating |
US20120316217A1 (en) * | 2009-12-21 | 2012-12-13 | Professional Dietetics S.R.L. | combination for the treatment of osteoarthritis |
EP2504001B1 (en) | 2009-11-26 | 2015-03-04 | Professional Dietetics S.r.l. | Combination for the treatment of radiation- or chemotherapy-induced mucositis |
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AU2010277668A1 (en) * | 2009-07-27 | 2012-03-01 | Ciro Caruso | Ophthalmic solution for protecting internal structures of the eyeball against UV-A rays or for the treatment of keratoconus with a trans-epithelial cross-linking technique |
US20120264681A1 (en) * | 2010-11-08 | 2012-10-18 | Healor Ltd. | Buffered ophthalmic compositions and methods of use thereof |
AT511164A1 (en) | 2011-03-03 | 2012-09-15 | Croma Pharma Gmbh | USE OF A VISCOELASTIC FLUID FOR THE MANUFACTURE OF A MEDICINE PRODUCT FOR SURGICAL TREATMENT OF THE EYE |
ITMI20110954A1 (en) * | 2011-05-26 | 2012-11-27 | Professional Dietetics Srl | COMBINATIONS FOR THE TREATMENT OF VAGINAL OR RECTAL MUCOSITES |
ES2604816B1 (en) * | 2015-09-09 | 2018-01-29 | Farmalider, S.A. | Pharmaceutical composition of tramadol for ophthalmic use |
IT201600116727A1 (en) * | 2016-11-18 | 2018-05-18 | Univ Politecnica Delle Marche | COMPOSED FOR THE HEALING OF WOUNDS |
AU2019311846B2 (en) | 2018-07-27 | 2023-02-23 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
US10966948B2 (en) | 2019-07-23 | 2021-04-06 | Johnson & Johnson Surgical Vision, Inc. | Compositions and methods for treating the eye |
EP4110393A1 (en) | 2020-02-28 | 2023-01-04 | Immunologik GmbH | Inhibitors of human deubiquitinases for the treatment of coronaviral infections |
US20230165851A1 (en) | 2020-04-27 | 2023-06-01 | Immunologik Gmbh | 6'-methoxycinchonan-9-ols for the treatment of coronaviral infections |
BR112022025134A2 (en) | 2020-06-10 | 2022-12-27 | Metriopharm Ag | 5-AMINO-2,3-DIHYDRO-1,4-PHTHALAZINEDIONE, COMPOSITION, COMBINATION AND METHOD OF TREATMENT OF A CORONAVIRAL INFECTION |
EP3981405A1 (en) | 2020-10-08 | 2022-04-13 | MetrioPharm AG | Compound for the treatment of coronaviral infections |
WO2022042873A1 (en) | 2020-08-27 | 2022-03-03 | Immunologik Gmbh | Pharmaceutically acceptable lectins derived from plants, fungi and bacteria for the treatment of sars-cov-2 infections |
IT202100029726A1 (en) | 2021-11-24 | 2023-05-24 | Professional Dietetics Spa | OPHTHALMIC COMPOSITIONS FOR THE TREATMENT OF CORNEAL LESIONS |
EP4193994A1 (en) | 2021-12-08 | 2023-06-14 | MetrioPharm AG | Combination of 5-amino-2,3-dihydro-1,4-phtalazinedione and a 6'-methoxycinchonan-9-ol for use in the treatment of coronaviral infections |
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-
2005
- 2005-10-26 IT IT002036A patent/ITMI20052036A1/en unknown
-
2006
- 2006-10-16 ES ES06806304T patent/ES2335437T3/en active Active
- 2006-10-16 DE DE602006011196T patent/DE602006011196D1/en active Active
- 2006-10-16 WO PCT/EP2006/009967 patent/WO2007048523A1/en active Application Filing
- 2006-10-16 JP JP2008536974A patent/JP5312946B2/en active Active
- 2006-10-16 CA CA2627215A patent/CA2627215C/en active Active
- 2006-10-16 KR KR1020087009861A patent/KR20080074107A/en active Search and Examination
- 2006-10-16 PL PL06806304T patent/PL1940381T3/en unknown
- 2006-10-16 US US12/091,481 patent/US20080249065A1/en not_active Abandoned
- 2006-10-16 AT AT06806304T patent/ATE451916T1/en not_active IP Right Cessation
- 2006-10-16 EP EP06806304A patent/EP1940381B1/en active Active
-
2010
- 2010-12-09 US US12/964,522 patent/US8524687B2/en active Active
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US5741817A (en) * | 1994-07-22 | 1998-04-21 | Chowhan; Masood | Use of low molecular weight amino acids in ophthalmic compositions |
US20030021834A1 (en) * | 1996-08-07 | 2003-01-30 | Petito George D. | Method for use of hyaluronic acid in wound management |
US20040006348A1 (en) * | 1999-08-26 | 2004-01-08 | The Spineology Group, Llc | Tools and method for processing and injecting bone graft material |
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US20080261915A1 (en) * | 2005-10-26 | 2008-10-23 | Solartium Llc | Wound-Healing Pharmaceutical Compositions in the Form of a Sterile Powder Based on Amino Acids and Sodium Hyaluronate |
US20080287392A1 (en) * | 2005-10-26 | 2008-11-20 | Solartium Llc | Wound-Healing Pharmaceutical Compositions in the Form of a Cream Based on Amino Acids and Sodium Hyaluronate |
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US20120316217A1 (en) * | 2009-12-21 | 2012-12-13 | Professional Dietetics S.R.L. | combination for the treatment of osteoarthritis |
US20110287064A1 (en) * | 2010-05-19 | 2011-11-24 | Heraeus Medical Gmbh | Antibiotic coating |
Also Published As
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ES2335437T3 (en) | 2010-03-26 |
PL1940381T3 (en) | 2010-05-31 |
ATE451916T1 (en) | 2010-01-15 |
EP1940381B1 (en) | 2009-12-16 |
US20110077219A1 (en) | 2011-03-31 |
KR20080074107A (en) | 2008-08-12 |
DE602006011196D1 (en) | 2010-01-28 |
ITMI20052036A1 (en) | 2007-04-27 |
JP2009513586A (en) | 2009-04-02 |
WO2007048523A1 (en) | 2007-05-03 |
EP1940381A1 (en) | 2008-07-09 |
CA2627215C (en) | 2015-03-24 |
JP5312946B2 (en) | 2013-10-09 |
CA2627215A1 (en) | 2007-05-03 |
US8524687B2 (en) | 2013-09-03 |
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