US20080261915A1 - Wound-Healing Pharmaceutical Compositions in the Form of a Sterile Powder Based on Amino Acids and Sodium Hyaluronate - Google Patents
Wound-Healing Pharmaceutical Compositions in the Form of a Sterile Powder Based on Amino Acids and Sodium Hyaluronate Download PDFInfo
- Publication number
- US20080261915A1 US20080261915A1 US12/091,551 US9155106A US2008261915A1 US 20080261915 A1 US20080261915 A1 US 20080261915A1 US 9155106 A US9155106 A US 9155106A US 2008261915 A1 US2008261915 A1 US 2008261915A1
- Authority
- US
- United States
- Prior art keywords
- proline
- leucine
- sodium hyaluronate
- wound
- lysine
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Abandoned
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/20—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing organic materials
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
- A61K31/198—Alpha-aminoacids, e.g. alanine, edetic acids [EDTA]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/22—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons containing macromolecular materials
- A61L15/28—Polysaccharides or their derivatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L15/00—Chemical aspects of, or use of materials for, bandages, dressings or absorbent pads
- A61L15/16—Bandages, dressings or absorbent pads for physiological fluids such as urine or blood, e.g. sanitary towels, tampons
- A61L15/42—Use of materials characterised by their function or physical properties
- A61L15/44—Medicaments
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/21—Acids
- A61L2300/214—Amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/20—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices containing or releasing organic materials
- A61L2300/23—Carbohydrates
- A61L2300/236—Glycosaminoglycans, e.g. heparin, hyaluronic acid, chondroitin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/45—Mixtures of two or more drugs, e.g. synergistic mixtures
Definitions
- the present invention relates to wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate.
- Bedsores and chronic ulcerous wounds are usually treated with gentle massage to restore the circulation, possibly with mechanical removal of the necrotic tissue and cleansing with soap (which can cause oedema or dehydration), or with hydrophilic polymers, hydrogen peroxide or alcohol rubs (which can cause damage because the removal of the fats in the cutaneous tissue dries and cracks the skin).
- the invention therefore relates to wound-healing pharmaceutical compositions in the form of a sterile powder, containing, as active ingredient, a combination of:
- compositions according to the invention contain glycine, L-proline and sodium hyaluronate, and possibly L-lysine in hydrochloride form, and L-leucine.
- compositions according to the invention have proved a surprising adjuvant effect in promoting the healing of wounds which cannot be stitched and have seriously damaged the dermis, including with loss of skin substance, such as chronic ulcerous wounds, serious burns and bedsores.
- compositions according to the invention promote the elimination of necrotic tissue, thus facilitating more rapid regeneration of the tissues, and maintain the ideal humidity conditions to aid re-epithelialisation of the skin lesions, at the same time preventing the spread of germs.
- the powder compositions will take the form of two separate capsules, one containing only proline, and the other containing the remaining active ingredients.
- proline —NH 2 group reacts with the hydroxyl groups on the hyaluronate, giving rise to a Maillard reaction, which considerably darkens the powder due to degradation of the amino acids.
- Powders from the two separate capsules will be applied to the affected area after removing any foreign material by thorough washing with a hydrogen peroxide solution or saline solution, and removing of any excess blood with sterile gauze.
- compositions according to the invention will contain the various active ingredients within the following percentage ranges by weight:
- sodium hyaluronate 0.5 to 3%
- L-lysine hydrochloride 0.05 to 1%
- compositions according to the invention will contain the various active ingredients in the following percentages by weight:
- compositions according to the invention can be formulated suitably for the topical administration in the form of a sterile powder, and prepared according to conventional methods well known in pharmaceutical technology, such as those described in Remington's Pharmaceutical Handbook, Mack Publishing Co., N.Y., USA, using excipients, solubilisers, emollients, stabilisers, emulsifiers, pH regulators, and preservatives acceptable for their final use.
- compositions of the invention to heal chronic sores in elderly patients, diabetics and patients with vascular disease was evaluated.
- the treatment was given three/four times a week, depending on the severity of the lesions, by spreading the sterile powder on the wound.
- the bedsores had to have a de-epithelialised area of over 10 cm 2 which had already been treated by conventional means for over 4 months, without any evident results.
- the type of bandage was irrelevant.
- the sterile powder compositions according to the invention obtained healing indexes (expressed as % improvement) exceeding 80% by comparison with conventional treatment.
- Each box contains five blister packs, each containing two hard gelatin capsules (capsule A and capsule B).
- Each capsule contains 438 mg (capsule A) and 150 mg (capsule B) of sterile powder.
- one capsule A and one capsule B are opened, and the powder contained in them is poured onto the wound.
- compositions of capsule A and capsule B are as follows:
- Capsule A (format 000-Snap-Fit-Code: 23000), transparent bright pink, contains 438 mg of powder with the following composition:
- Ingredients One capsule contains Powder (mg) Sodium hyaluronate 199.47 Glycine 182.10 L-Lysine hydrochloride 34.89 L-Leucine 21.54 Total 438.00
- Capsule B (format 000-Snap-Fit-Code: 43000), transparent, contains 150 mg of powder with the following composition:
- Ingredients One capsule contains Powder (mg) L-Proline 150.0 Total 150.0
Abstract
This invention relates to wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate.
Description
- The present invention relates to wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate.
- In the absence of suitable preventive actions, patients who are paralysed or bedridden for long periods are liable to ischaemic necrosis and ulceration of the tissues covering projecting bones, especially in the sacral, ischial, malleolar, heel and great trochanter regions.
- Bedsores and chronic ulcerous wounds are usually treated with gentle massage to restore the circulation, possibly with mechanical removal of the necrotic tissue and cleansing with soap (which can cause oedema or dehydration), or with hydrophilic polymers, hydrogen peroxide or alcohol rubs (which can cause damage because the removal of the fats in the cutaneous tissue dries and cracks the skin).
- Serious burns also require debridement of the affected area and removal of necrotic tissue.
- It has now been found that the combination of some amino acids with sodium hyaluronate is particularly effective in promoting the process of cell reintegration which forms the basis for fast wound-healing, aiding the reconstruction of connective tissue and the consequent regeneration of epithelial cells.
- The invention therefore relates to wound-healing pharmaceutical compositions in the form of a sterile powder, containing, as active ingredient, a combination of:
- a) glycine and proline;
- b) sodium hyaluronate; and possibly
- c) lysine and leucine.
- More particularly, the compositions according to the invention contain glycine, L-proline and sodium hyaluronate, and possibly L-lysine in hydrochloride form, and L-leucine.
- The compositions according to the invention have proved a surprising adjuvant effect in promoting the healing of wounds which cannot be stitched and have seriously damaged the dermis, including with loss of skin substance, such as chronic ulcerous wounds, serious burns and bedsores.
- The compositions according to the invention promote the elimination of necrotic tissue, thus facilitating more rapid regeneration of the tissues, and maintain the ideal humidity conditions to aid re-epithelialisation of the skin lesions, at the same time preventing the spread of germs.
- According to the invention, the powder compositions will take the form of two separate capsules, one containing only proline, and the other containing the remaining active ingredients.
- Separation of proline from the other active ingredients in the powder form is necessary for reasons of stability, because under conditions of low humidity, the proline —NH2 group reacts with the hydroxyl groups on the hyaluronate, giving rise to a Maillard reaction, which considerably darkens the powder due to degradation of the amino acids.
- Powders from the two separate capsules will be applied to the affected area after removing any foreign material by thorough washing with a hydrogen peroxide solution or saline solution, and removing of any excess blood with sterile gauze.
- The compositions according to the invention will contain the various active ingredients within the following percentage ranges by weight:
- glycine 0.5 to 2%;
- L-proline: 0.2 to 1.5%;
- sodium hyaluronate: 0.5 to 3%;
- and possibly
- L-lysine hydrochloride: 0.05 to 1%;
- L-leucine: 0.05 to 0.3%.
- According to a preferred aspect, the compositions according to the invention will contain the various active ingredients in the following percentages by weight:
- glycine 1%;
- L-proline: 0.75%;
- sodium hyaluronate: 1.33%;
- and possibly
- L-lysine hydrochloride: 0.1%;
- L-leucine: 0.15%.
- The compositions according to the invention can be formulated suitably for the topical administration in the form of a sterile powder, and prepared according to conventional methods well known in pharmaceutical technology, such as those described in Remington's Pharmaceutical Handbook, Mack Publishing Co., N.Y., USA, using excipients, solubilisers, emollients, stabilisers, emulsifiers, pH regulators, and preservatives acceptable for their final use.
- The ability of the compositions of the invention to heal chronic sores in elderly patients, diabetics and patients with vascular disease was evaluated.
- In particular, 40 elderly patients suffering from bedsores, 36 Type II diabetics with ulcers extending to the lower limbs, and 32 patients with post-phlebitic ulcers were evaluated.
- The treatment was given three/four times a week, depending on the severity of the lesions, by spreading the sterile powder on the wound.
- The bedsores had to have a de-epithelialised area of over 10 cm2 which had already been treated by conventional means for over 4 months, without any evident results. The type of bandage was irrelevant.
- The sore was clinically evaluated and photographed before treatment in the fourth and eighth weeks of the trial. “Healing” was defined as closing of the wounds, and “improvement” as a reduction in size of the treated area exceeding 70% of the initial area.
- By the fourth week of treatment 18 patients showed an improvement, namely a reduction in size of the sore of over 70%, and 2 were completely healed; by the end of the observation period (8th week), 24 patients were healed, 10 had improved and 3 patients presented a reduction of under 50% in the de-epithelialised area. 2 Patients were hospitalized for concomitant pathologies and 1 worsened due to superinfection.
- Of the 36 diabetics with ulcers of various areas and depths, which had already been treated unsuccessfully for at least four months prior to our study, 12 were healed after four weeks' treatment, and another 30 no longer presented ulcerated areas by the end of treatment period. In 4 particularly serious cases there was an improvement, but the sore was still present by the end of the 8th week of treatment.
- In patients with post-phlebitic ulcers who had already undergone conventional treatment for at least two months with no result, the administration of the sterile powder compositions according to the invention led to healing within one month in 18 patients and by the end of treatment (8th week) in another 10 patients, making a total of 28 out of 32 treated.
- In conclusion, in the case of bedsores, diabetic and post-phlebitic skin ulcers, the sterile powder compositions according to the invention obtained healing indexes (expressed as % improvement) exceeding 80% by comparison with conventional treatment.
- An example of a sterile powder formulation according to the invention is set out below.
- Each box contains five blister packs, each containing two hard gelatin capsules (capsule A and capsule B).
- Each capsule contains 438 mg (capsule A) and 150 mg (capsule B) of sterile powder.
- Before topical application, one capsule A and one capsule B are opened, and the powder contained in them is poured onto the wound.
- The compositions of capsule A and capsule B are as follows:
- Each Capsule A (format 000-Snap-Fit-Code: 23000), transparent bright pink, contains 438 mg of powder with the following composition:
-
Ingredients One capsule contains Powder (mg) Sodium hyaluronate 199.47 Glycine 182.10 L-Lysine hydrochloride 34.89 L-Leucine 21.54 Total 438.00 - Each Capsule B (format 000-Snap-Fit-Code: 43000), transparent, contains 150 mg of powder with the following composition:
-
Ingredients One capsule contains Powder (mg) L-Proline 150.0 Total 150.0
Claims (10)
1-4. (canceled)
5. A topical pharmaceutical composition in sterile powder form, containing as active ingredient a combination of:
a) glycine and proline; and
b) sodium hyaluronate.
6. The topical pharmaceutical composition of claim 5 , the composition further comprising as active ingredient:
c) lysine and leucine.
7. The topical pharmaceutical composition of claim 5 , wherein proline is L-proline, and wherein glycine, L-proline and sodium hyaluronate are comprised within the following percentage ranges by weight:
glycine 0.5 to 2%;
L-proline. 0.2 to 1.5%; and
sodium hyaluronate: 0.5 to 3%.
8. The topical pharmaceutical composition of claim 6 , wherein lysine is L-lysine, leucine is L-leucine and wherein L-lysine and L-leucine are comprised within the following percentage ranges by weight:
L-lysine hydrochloride: 0.05 to 1%; and
L-leucine: 0.05 to 0.3%.
9. The topical pharmaceutical composition of claim 5 , wherein proline is L-proline, and wherein glycine, L-proline and sodium hyaluronate have the following percentage by weight:
glycine 1%;
L-proline: 0.75%; and
sodium hyaluronate: 1.33%.
10. The topical pharmaceutical composition of claim 6 , wherein lysine is L-lysine, leucine is L-leucine and wherein L-lysine and L-leucine have the following percentage by weight:
L-lysine hydrochloride: 0.1%; and
L-leucine: 0.15%.
11. A method for treating a wound in a biological tissue, the method comprising
administering to the biological tissue a topical medicament in sterile powder, the topical medicament comprising a combination of
a) glycine and proline; and
b) sodium hyaluronate.
12. The method of claim 11 , wherein the medicament further comprises
c) lysine and leucine.
13. The method of claim 11 , wherein, the wound is a chronic ulcerous wound, a serious burn, a surgical wound, a chronic ulcerous wound, a serious burn or a surgical wound.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
IT002037A ITMI20052037A1 (en) | 2005-10-26 | 2005-10-26 | PHARMACEUTICAL COMPOSITIONS CHICATRIZERS UNDER THE FORM OF STERILE POWDER BASED ON AMINO ACIDS AND SODIUM HYALURONATE |
ITMI2005A002037 | 2005-10-26 | ||
PCT/EP2006/009968 WO2007048524A2 (en) | 2005-10-26 | 2006-10-16 | Wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate |
Related Parent Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/EP2006/009968 A-371-Of-International WO2007048524A2 (en) | 2005-10-26 | 2006-10-16 | Wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate |
Related Child Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/964,419 Continuation US8426384B2 (en) | 2005-10-26 | 2010-12-09 | Wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate |
Publications (1)
Publication Number | Publication Date |
---|---|
US20080261915A1 true US20080261915A1 (en) | 2008-10-23 |
Family
ID=37903460
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/091,551 Abandoned US20080261915A1 (en) | 2005-10-26 | 2006-09-16 | Wound-Healing Pharmaceutical Compositions in the Form of a Sterile Powder Based on Amino Acids and Sodium Hyaluronate |
US12/964,419 Active US8426384B2 (en) | 2005-10-26 | 2010-12-09 | Wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
US12/964,419 Active US8426384B2 (en) | 2005-10-26 | 2010-12-09 | Wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate |
Country Status (11)
Country | Link |
---|---|
US (2) | US20080261915A1 (en) |
EP (1) | EP1940478B1 (en) |
JP (1) | JP5334584B2 (en) |
KR (1) | KR101367340B1 (en) |
AT (1) | ATE498413T1 (en) |
CA (1) | CA2627223C (en) |
DE (1) | DE602006020155D1 (en) |
ES (1) | ES2357415T3 (en) |
IT (1) | ITMI20052037A1 (en) |
PT (1) | PT1940478E (en) |
WO (1) | WO2007048524A2 (en) |
Cited By (6)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20080249065A1 (en) * | 2005-10-26 | 2008-10-09 | Franco Conti | Ophthalmic Pharmaceutical Compositions Based on Amino Acids and Sodium Hyaluronate |
US20080287392A1 (en) * | 2005-10-26 | 2008-11-20 | Solartium Llc | Wound-Healing Pharmaceutical Compositions in the Form of a Cream Based on Amino Acids and Sodium Hyaluronate |
US20110077218A1 (en) * | 2005-10-26 | 2011-03-31 | Solartium Llc | Wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate |
CN102655861A (en) * | 2009-11-26 | 2012-09-05 | 专业营养有限公司 | Combination for the treatment of radiation- or chemotherapy-induced mucositis |
CN102665708A (en) * | 2009-12-21 | 2012-09-12 | 专业营养有限公司 | A combination for the treatment of osteoarthritis |
CN111748071A (en) * | 2020-06-29 | 2020-10-09 | 武汉瑞法医疗器械有限公司 | Hydrophilic polyurethane foam dressing and preparation method thereof |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ITMI20110954A1 (en) * | 2011-05-26 | 2012-11-27 | Professional Dietetics Srl | COMBINATIONS FOR THE TREATMENT OF VAGINAL OR RECTAL MUCOSITES |
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US4707354A (en) * | 1985-06-17 | 1987-11-17 | Alpen Tau, Inc. | Mature skin treatment and protectant compositions and methods of using same |
US5741817A (en) * | 1994-07-22 | 1998-04-21 | Chowhan; Masood | Use of low molecular weight amino acids in ophthalmic compositions |
US20020013359A1 (en) * | 2000-06-07 | 2002-01-31 | Dioguardi Francesco Saverio | Pharmaceutical composition based on proline, glycine and lysine used in the therapy for the healing of tendon lesions and open wounds |
US20030021834A1 (en) * | 1996-08-07 | 2003-01-30 | Petito George D. | Method for use of hyaluronic acid in wound management |
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US20080249065A1 (en) * | 2005-10-26 | 2008-10-09 | Franco Conti | Ophthalmic Pharmaceutical Compositions Based on Amino Acids and Sodium Hyaluronate |
US20080287392A1 (en) * | 2005-10-26 | 2008-11-20 | Solartium Llc | Wound-Healing Pharmaceutical Compositions in the Form of a Cream Based on Amino Acids and Sodium Hyaluronate |
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CA1165243A (en) * | 1980-02-19 | 1984-04-10 | Anthony N. Silvetti | Method and composition for treatment of wounds |
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FR2820635B1 (en) * | 2001-02-09 | 2005-01-21 | Genevrier Lab | PROCESS FOR THE PREPARATION OF A CREAM BASED ON HYALURONIC ACID |
ITTO20010804A1 (en) * | 2001-08-08 | 2003-02-08 | Professional Dietetics Srl | COMPOSITIONS BASED ON AMINO ACIDS, SUITABLE FOR THERAPY FOR CICATRIZATION AND / OR REPAIR OF INJURIES AND INJURIES, IN PARTICULAR FOR THE APP |
FR2864445B1 (en) * | 2003-12-30 | 2006-04-28 | Jean Noel Thorel | TOPICAL USE OF A COMPLEX NUTRIENT BASE |
ITMI20052037A1 (en) | 2005-10-26 | 2007-04-27 | Professional Dietetics Srl | PHARMACEUTICAL COMPOSITIONS CHICATRIZERS UNDER THE FORM OF STERILE POWDER BASED ON AMINO ACIDS AND SODIUM HYALURONATE |
-
2005
- 2005-10-26 IT IT002037A patent/ITMI20052037A1/en unknown
-
2006
- 2006-09-16 US US12/091,551 patent/US20080261915A1/en not_active Abandoned
- 2006-10-16 PT PT06806305T patent/PT1940478E/en unknown
- 2006-10-16 JP JP2008536975A patent/JP5334584B2/en not_active Expired - Fee Related
- 2006-10-16 ES ES06806305T patent/ES2357415T3/en active Active
- 2006-10-16 CA CA2627223A patent/CA2627223C/en not_active Expired - Fee Related
- 2006-10-16 EP EP06806305A patent/EP1940478B1/en not_active Not-in-force
- 2006-10-16 KR KR1020087009862A patent/KR101367340B1/en active IP Right Grant
- 2006-10-16 AT AT06806305T patent/ATE498413T1/en active
- 2006-10-16 WO PCT/EP2006/009968 patent/WO2007048524A2/en active Application Filing
- 2006-10-16 DE DE602006020155T patent/DE602006020155D1/en active Active
-
2010
- 2010-12-09 US US12/964,419 patent/US8426384B2/en active Active
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US20080249065A1 (en) * | 2005-10-26 | 2008-10-09 | Franco Conti | Ophthalmic Pharmaceutical Compositions Based on Amino Acids and Sodium Hyaluronate |
US20080287392A1 (en) * | 2005-10-26 | 2008-11-20 | Solartium Llc | Wound-Healing Pharmaceutical Compositions in the Form of a Cream Based on Amino Acids and Sodium Hyaluronate |
US20110077218A1 (en) * | 2005-10-26 | 2011-03-31 | Solartium Llc | Wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate |
US8426384B2 (en) | 2005-10-26 | 2013-04-23 | Professional Dietetics S.R.L. | Wound-healing pharmaceutical compositions in the form of a sterile powder based on amino acids and sodium hyaluronate |
US8524687B2 (en) | 2005-10-26 | 2013-09-03 | Professional Dietetics S.R.L. | Ophthalmic pharmaceutical compositions based on amino acids and sodium hyaluronate |
CN102655861A (en) * | 2009-11-26 | 2012-09-05 | 专业营养有限公司 | Combination for the treatment of radiation- or chemotherapy-induced mucositis |
US20130039881A1 (en) * | 2009-11-26 | 2013-02-14 | Professional Dietetics S.R.L | Combination for the treatment of radiation- or chemotherapy-induced mucositis |
CN102665708A (en) * | 2009-12-21 | 2012-09-12 | 专业营养有限公司 | A combination for the treatment of osteoarthritis |
CN102665708B (en) * | 2009-12-21 | 2014-11-05 | 专业营养有限公司 | A combination for the treatment of osteoarthritis |
CN111748071A (en) * | 2020-06-29 | 2020-10-09 | 武汉瑞法医疗器械有限公司 | Hydrophilic polyurethane foam dressing and preparation method thereof |
Also Published As
Publication number | Publication date |
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JP5334584B2 (en) | 2013-11-06 |
KR20080065982A (en) | 2008-07-15 |
JP2009513587A (en) | 2009-04-02 |
EP1940478B1 (en) | 2011-02-16 |
US20110077218A1 (en) | 2011-03-31 |
PT1940478E (en) | 2011-03-07 |
US8426384B2 (en) | 2013-04-23 |
ES2357415T3 (en) | 2011-04-26 |
ITMI20052037A1 (en) | 2007-04-27 |
WO2007048524A2 (en) | 2007-05-03 |
KR101367340B1 (en) | 2014-02-28 |
WO2007048524A3 (en) | 2008-01-31 |
DE602006020155D1 (en) | 2011-03-31 |
CA2627223C (en) | 2014-04-08 |
CA2627223A1 (en) | 2007-05-03 |
EP1940478A2 (en) | 2008-07-09 |
ATE498413T1 (en) | 2011-03-15 |
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