US3560614A - Use of a keratolytic shampoo - Google Patents

Use of a keratolytic shampoo Download PDF

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Publication number
US3560614A
US3560614A US612782A US3560614DA US3560614A US 3560614 A US3560614 A US 3560614A US 612782 A US612782 A US 612782A US 3560614D A US3560614D A US 3560614DA US 3560614 A US3560614 A US 3560614A
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United States
Prior art keywords
acid
shampoo
shampoo preparation
salicylic acid
hair
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Expired - Lifetime
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US612782A
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Paul G Embring
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Medisan AB
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Medisan AB
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q5/00—Preparations for care of the hair
    • A61Q5/02—Preparations for cleaning the hair
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/36—Carboxylic acids; Salts or anhydrides thereof
    • A61K8/368—Carboxylic acids; Salts or anhydrides thereof with carboxyl groups directly bound to carbon atoms of aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
    • A61K8/37—Esters of carboxylic acids

Definitions

  • a shampoo preparation consisting of a mixture comprising salicylic acid, an anionic surface active agent, alkyllesters of phthalic acid and/or adipic acid, and optionally water is provided.
  • the present invention relates to a shampoo preparation consisting of a mixture which comprises salicylic acid, anionic wetting agents and preferably also water.
  • Such shampoo preparations are previously known. They have been used for treating hair and the roots thereof for the purpose of cleaning the same.
  • the most active constituents of such a preparation is the anionic wetting agent.
  • the function of the salicylic acid is to combat micro-organisms, primarily fungi. It also has a keratolytic effect, i.e. it is capable of breaking up hard skin.
  • the invention is therefore characterized in that, for this purpose, one or more lower alkyl esters of phthalic acid and/ or adipic acid are incorporated into the shampoo preparation.
  • the percentages of the various constituents in the shampoo preparation may be varied within wide limits. Usually, however, the percentage of salicylic acid lies between 0.1 and 5 percent by weight, the percentage of anionic wetting agents between and 80 percent by weight and the percentage of fat dissolving organic solvent between 1 and percent by weight. If the shampoo preparation contains water, which is usually the case, the percentage thereof does not usually exceed 90 percent by weight. All the above percentages are calculated on the total weight of the shampoo preparation.
  • Examples of appropriate solvents according to the invention are: dimethyl-phthalate, diethyl-phthalate, and di-n-butyl-phthalate, and, further, dimethyl-adipate, diethyladipate, diisopropyl-adipate and di-n-butyl-adipate. Particularly good results have been obtained with dimethyl-phthalate.
  • anionic wetting agents are dioctyl-sodium sulphosuccinate, sodium laurylsulphoacetate, sodium laurylsulphate, sodium tetradecylsulphate.
  • Salicylic acid may also be introduced into the composition in the form of a derivative hydrolyzable thereto, e.g. in the form of an ester, which forms the free acid in the presence of water.
  • the shampoo preparation according to the aforegoing may also include other facultative constituents which give specific effects.
  • Such constituents are cetanol, lanolin and glycerylmonostearate, which may be added as consistency regulators.
  • Lecithin may be added to improve the skin sensitivity of the agent.
  • thickening agents, perfumes and colouring agents may be added, as well as agents which heighten the antiseptic effect of the salicyclic acid, e.g. benzoic acid, lower alkyl esters of p-hydroxybenzoic acid and hexachlorophenol.
  • the shampoo preparation according to the invention has been shown to give good results if the hair subsequent to being treated with the same is treated with an antiseptic hair wash.
  • An example of such a wash is one which consists of a solution or dispersion comprising pantothenol, whereby'it is particularly emphasized that extraordinarily satisfactory results can be obtained if the hair wash also includes surface active quaternary ammonium compounds having an antimicrobial effect.
  • Salicylic acid powder 2 Dimethyl phthalate 5 Monostearine 2.5 Cetanol 2.5 Sodium dodecylsulphate 10 Sodium dodecylbenzenesulphonate 50 Water to g.
  • the shampoo preparation when applied to hair and the capillary matrix was shown to prossess an extraordinarily good cleaning and softening effect.
  • the shampoo preparation when applied to hair and the capillary matrix was shown to possess an extraordinarily good cleaning and softening elfect.
  • Pur-cellin oil is the same as PCL liquid which is a branched chain alkyl fatty acid ester with low solidification point. It is an ester of the fatty acid most probably with a simple alcohol such as ethyl alcohol or isopropyl alcohol. Dragoco Inc., Totowa,
  • the shampoo preparation when applied to hair and the capillary matrix was shown to possess an extraordinarily good cleaning and softening effect.
  • the shampoo preparation when applied to hair and capillary matrix was shown to possess an extraordinarily good cleaning and softening effect.
  • Salicylic acid fine powder 2 Dimethyl phthalate 5 Sodium lauryl sulphate 20 coconut” monoethanolamide 1 Propylene glycol monostearate 2 Stearic acid 5 Water and perfume to 100 g.
  • the shampoo preparation when applied to hair and capillary matrix was shown to possess an extraordinarily good cleaning and softening effect.

Abstract

A SHAMPOO PREPARATION CONSISTING OF A MIXTURE COMPRISING SALICYLIC ACID, AN ANIONIC SURFACE ACTIVE AGENT, ALKYL ESTERS OF PHTHALIC ACID AND/OR ADIPIE ACID, AND OPTIONALLY WATER IS PROVIDED.

Description

United States Patent US. Cl. 424-234 1 Claim ABSTRACT OF THE DISCLOSURE A shampoo preparation consisting of a mixture comprising salicylic acid, an anionic surface active agent, alkyllesters of phthalic acid and/or adipic acid, and optionally water is provided.
The present invention relates to a shampoo preparation consisting of a mixture which comprises salicylic acid, anionic wetting agents and preferably also water.
Such shampoo preparations are previously known. They have been used for treating hair and the roots thereof for the purpose of cleaning the same. The most active constituents of such a preparation is the anionic wetting agent. The function of the salicylic acid is to combat micro-organisms, primarily fungi. It also has a keratolytic effect, i.e. it is capable of breaking up hard skin.
It has now been shown that the effect of the salicylic acid in particular can be increased considerably if certain fat dissolving organic solvents are added to the shampoo. Particular examples of such agents are lower aliphatic esters of any of the two dibasic acids phthalic acid and adipic acid, or mixtures thereof. These solvents have a good therapeutical acceptance and a low degree of volatility which is of importance with respect to fire risk and odour. Their most important property, however, is that they have been shown surprisingly capable, when coming into contact with the skin, of softening the wax-like layers of skin fat which normally cover the capillary matrix, so that the scalp is cleaned more effectively. Consequently the salicylic acid, in turn, acts keratolyticly.
The invention is therefore characterized in that, for this purpose, one or more lower alkyl esters of phthalic acid and/ or adipic acid are incorporated into the shampoo preparation.
The percentages of the various constituents in the shampoo preparation may be varied within wide limits. Usually, however, the percentage of salicylic acid lies between 0.1 and 5 percent by weight, the percentage of anionic wetting agents between and 80 percent by weight and the percentage of fat dissolving organic solvent between 1 and percent by weight. If the shampoo preparation contains water, which is usually the case, the percentage thereof does not usually exceed 90 percent by weight. All the above percentages are calculated on the total weight of the shampoo preparation.
Examples of appropriate solvents according to the invention are: dimethyl-phthalate, diethyl-phthalate, and di-n-butyl-phthalate, and, further, dimethyl-adipate, diethyladipate, diisopropyl-adipate and di-n-butyl-adipate. Particularly good results have been obtained with dimethyl-phthalate.
Examples of anionic wetting agents are dioctyl-sodium sulphosuccinate, sodium laurylsulphoacetate, sodium laurylsulphate, sodium tetradecylsulphate. Salicylic acid may also be introduced into the composition in the form of a derivative hydrolyzable thereto, e.g. in the form of an ester, which forms the free acid in the presence of water.
ice
In addition to the above ingredients obligatory, the shampoo preparation according to the aforegoing may also include other facultative constituents which give specific effects. Examples of such constituents are cetanol, lanolin and glycerylmonostearate, which may be added as consistency regulators. Lecithin may be added to improve the skin sensitivity of the agent. Further, thickening agents, perfumes and colouring agents may be added, as well as agents which heighten the antiseptic effect of the salicyclic acid, e.g. benzoic acid, lower alkyl esters of p-hydroxybenzoic acid and hexachlorophenol.
The shampoo preparation according to the invention has been shown to give good results if the hair subsequent to being treated with the same is treated with an antiseptic hair wash. An example of such a wash is one which consists of a solution or dispersion comprising pantothenol, whereby'it is particularly emphasized that extraordinarily satisfactory results can be obtained if the hair wash also includes surface active quaternary ammonium compounds having an antimicrobial effect.
The invention will now be clarified by examples.
EXAMPLE 1 A shampoo preparation was made up by mixing the following constituents:
G. Salicylic acid, powder 2 Dimethyl phthalate 5 Monostearine 2.5 Cetanol 2.5 Sodium dodecylsulphate 10 Sodium dodecylbenzenesulphonate 50 Water to g.
The shampoo preparation when applied to hair and the capillary matrix, was shown to prossess an extraordinarily good cleaning and softening effect.
EXAMPLE 2 A shampoo preparation was made up by mixing the following constituents:
G. Salicylic acid, powder 2 Ethyl-p-oxy-benzoate 1 Isopropyl adipate 6 Triethanolamine laurylsulphate 35 Water, perfume and colouring agent to 100 g.
The shampoo preparation when applied to hair and the capillary matrix was shown to possess an extraordinarily good cleaning and softening elfect.
EXAMPLE 3 A shampoo preparation was made up by mixing the following constituents:
Salicylic acid 20 Dimethyl phthalate 50 Turkish red oil 720 Pur-cellin oil (Pur-cellin oil is the same as PCL liquid which is a branched chain alkyl fatty acid ester with low solidification point. It is an ester of the fatty acid most probably with a simple alcohol such as ethyl alcohol or isopropyl alcohol. Dragoco Inc., Totowa,
NJ.) 40 Oleyl alcohol 30 Glycerol 30 Water and perfume oil to 1,000 g.
The shampoo preparation when applied to hair and the capillary matrix, was shown to possess an extraordinarily good cleaning and softening effect.
EXAMPLE 4 A shampoo preparation was made up by mixing the following constituents:
G. Salicylic acid 2 Dimethyl phthalate 10 Sodium chloride 2 Standapol S (Standapol S is a trademark for triethanol lauryl sulfate. Standard Chem. Prod., Hoboken, NJ.) 35
Water and perfume to 100 g.
The shampoo preparation when applied to hair and capillary matrix, was shown to possess an extraordinarily good cleaning and softening effect.
EXAMPLE 5 A shampoo preparation was made up by mixing the following constituents:
G. Salicylic acid, fine powder 2 Dimethyl phthalate 5 Sodium lauryl sulphate 20 Coconut" monoethanolamide 1 Propylene glycol monostearate 2 Stearic acid 5 Water and perfume to 100 g.
The shampoo preparation when applied to hair and capillary matrix, was shown to possess an extraordinarily good cleaning and softening effect.
References Cited UNITED STATES PATENTS 3,326,808 6/1967 Noseworthy 252-106 OTHER REFERENCES Stedmans Medical Dictionary, 12th edition, 1961, pp. 1340-1341.
Harry, R. C.: The Principles and Practice of Modern Cosmetics, vol. II, 1963, pp. 181-182.-
Finnerty, E. F.: New England Journal of Medicine, vol. 255, Sept. 27, 1956, pp. 614-616.
Thomssen, E. G.: Modern Cosmetics, 3rd edition, 1947, pp. 504-505.
Sagarin, E.: Cosmetics, Science and Technology, 1957, pp. 382, 404-405, 390-391.
ALBERT T. MEYERS, Primary Examiner N. A. DREZIN, Assistant Examiner US. Cl. X.R.
US612782A 1966-01-31 1967-01-31 Use of a keratolytic shampoo Expired - Lifetime US3560614A (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE01175/66A SE327049B (en) 1966-01-31 1966-01-31

Publications (1)

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US3560614A true US3560614A (en) 1971-02-02

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US (1) US3560614A (en)
AT (1) AT270073B (en)
BE (1) BE693350A (en)
CH (1) CH467071A (en)
DE (1) DE1617632A1 (en)
DK (1) DK112754B (en)
FI (1) FI44672C (en)
FR (1) FR1513652A (en)
GB (1) GB1106945A (en)
NL (1) NL6701485A (en)
NO (1) NO120697B (en)
SE (1) SE327049B (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822604A (en) * 1985-05-20 1989-04-18 S. C. Johnson & Son, Inc. Local treatment of dandruff, seborrheic dermatitis, and psoriasis
US5449519A (en) * 1994-08-09 1995-09-12 Revlon Consumer Products Corporation Cosmetic compositions having keratolytic and anti-acne activity
US5834409A (en) * 1995-03-31 1998-11-10 Colgate-Palmolive Company Scalp care products containing anti itching/anti irritant agents
US5891449A (en) * 1993-10-21 1999-04-06 Stockhausen Gmbh & Co. Kg Skin cleaning agents, a process for their production and their use
US20110124606A1 (en) * 2007-11-19 2011-05-26 Snow Brand Milk Products Co., Ltd. Sense-improving agent

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4376787A (en) 1979-12-03 1983-03-15 Economics Laboratory, Inc. Control of mastitis
GB2145931A (en) * 1983-08-26 1985-04-11 David Maxwell Brown Dimethyl phthalate preparations
FR2714290B1 (en) * 1993-12-23 1996-04-19 Gilles Pelbois Hair lotion to fight against dandruff.
GB2343189B (en) * 1998-10-27 2002-11-20 Tetrosyl Ltd Skin cleansing composition
FR3124080A1 (en) * 2021-06-21 2022-12-23 Evergreen Land Limited Antimicrobial topical formulation

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4822604A (en) * 1985-05-20 1989-04-18 S. C. Johnson & Son, Inc. Local treatment of dandruff, seborrheic dermatitis, and psoriasis
US5891449A (en) * 1993-10-21 1999-04-06 Stockhausen Gmbh & Co. Kg Skin cleaning agents, a process for their production and their use
US6235296B1 (en) * 1993-10-21 2001-05-22 Chemische Fabrik Stockhausen Gmbh Skin cleaning agents, a process for their production and their use
US5449519A (en) * 1994-08-09 1995-09-12 Revlon Consumer Products Corporation Cosmetic compositions having keratolytic and anti-acne activity
US5834409A (en) * 1995-03-31 1998-11-10 Colgate-Palmolive Company Scalp care products containing anti itching/anti irritant agents
US20110124606A1 (en) * 2007-11-19 2011-05-26 Snow Brand Milk Products Co., Ltd. Sense-improving agent

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GB1106945A (en) 1968-03-20
NO120697B (en) 1970-11-23
SE327049B (en) 1970-08-10
DE1617632A1 (en) 1971-04-01
FR1513652A (en) 1968-02-16
FI44672B (en) 1971-08-31
BE693350A (en) 1967-07-31
NL6701485A (en) 1967-08-01
FI44672C (en) 1971-12-10
AT270073B (en) 1969-04-10
CH467071A (en) 1969-01-15
DK112754B (en) 1969-01-13

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