US3672351A - Disposable blood test device - Google Patents

Disposable blood test device Download PDF

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Publication number
US3672351A
US3672351A US64509A US3672351DA US3672351A US 3672351 A US3672351 A US 3672351A US 64509 A US64509 A US 64509A US 3672351D A US3672351D A US 3672351DA US 3672351 A US3672351 A US 3672351A
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test device
blood
glove
pad
affixed
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US64509A
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Richard W Ubersax
Andrew Truhan
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B42/00—Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof
    • A61B42/10—Surgical gloves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B10/00—Other methods or instruments for diagnosis, e.g. instruments for taking a cell sample, for biopsy, for vaccination diagnosis; Sex determination; Ovulation-period determination; Throat striking implements
    • A61B10/0038—Devices for taking faeces samples; Faecal examination devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B42/00—Surgical gloves; Finger-stalls specially adapted for surgery; Devices for handling or treatment thereof

Definitions

  • ABSTRACT A disposable device for testing the contents of accessible body cavities is provided by a glove of impermeable material having a pad of bibulous material impregnated with a test composition affixed to the thumb ofthe glove in a position contactable by the tip of any of the fingers thereof.
  • the test pad may be affixed either to the base of the thumb of the glove or to the inner surface of the distal end thereof or to both positions.
  • the pad of bibulous material is impregnated with a blood diagnostic composition the device is useful in the detection of occult blood in accessible body cavities such as the rectum.
  • the invention relates to a convenient disposable device for testing the contents of accessible body cavities, such as the rectum, in the course of palpation of the body cavity by a physician.
  • a convenient disposable device for testing the contents of accessible body cavities, such as the rectum, in the course of palpation of the body cavity by a physician.
  • Such a device is provided by a glove of impermeable material having a pad of bibulous material impregnated with a test composition affixed to the thumb of the glove in a position contactable by the tip of any of the fingers thereof.
  • the test pad may be affixed either to the base of the thumb or to the inner surface of the distal end thereof or to both positions.
  • the test pad is impregnated with a blood diagnostic composition.
  • the presence of occult blood in the rectal contents may be indicative of gastrointestinal cancer or ulcers or of hemorrhoids and means for rapidly and conveniently detecting thepresence of such blood in the rectal contents without carrying out complicated laboratory procedures is highly desirable.
  • the test device of the invention will be more fully described with reference to its use for the detection of occult blood in body cavity contents.
  • H6. 1 is a representation in palm view of the device of the invention.
  • FIG. 2 is a representation of the device of the invention as used in testing any substance adhering to a finger tip of the device;
  • FIG. 3 is a partial section on line 3-3 of FIG. 2.
  • 1 is a glove of an impermeable material, such as rubber or other elastic or plastic material and 2 is the impregnated test patch affixed to the external base of the thumb portion of glove 1 or to the distal end thereof as indicated at 2' in dotted lines.
  • the patch may be made of paper, cloth, felt or other bibulous material, impregnated with a composition activated by the presence of blood to undergo a color change.
  • Suitable compositions for the detection of blood are well known in the art. They include peroxidic substances which release under acidic conditions hydrogen peroxide or other active oxidants and indicator substances oxidizable by the released oxidant to form highly colored reaction products.
  • Typical peroxidic substances include inorganic compounds, such as peroxides, perborates and persulfates of the alkali and alkaline earth metals and organic peroxides and organic hydroperoxides such as cumenehydroperoxide and diisopropylbenzenehydroperoxide.
  • Suitable oxidizable dye-forming compounds include benzidine, o-tolidine, o-toluidine, o-phenylene-diamine, N,N dimethyl-p-phenylene-diamine, N,N-diethyl-p-phenylenediamine, p-anisidine, o-cresol, m-cresol, p-cresol, a-naphthol, B-naphthol, catechol, guaiacol and pyrogallol.
  • the acidic component of the composition is preferably a normally solid, water-soluble organic acid such as citric and oxalic acids.
  • a typical impregnating composition consists of parts by weight of citric acid, 10 parts by weight of benzidine and 25 parts by weight of barium peroxide. This composition will develop a blue color in the presence of blood hemoglobin.
  • the test patches may be made by impregnating filter paper with an aqueous solution of the citric acid, drying the paper, impregnating the dried paper with a suspension of the barium peroxide in a chloroform solution of the benzidine and evaporating the chloroform.
  • the dried impregnated paper is cut into patches of suitable size and shape and the patches are afiixed to the base of the thumb portion of rubber gloves with a suitable adhesive, such as rubber cement.
  • a disposable test device comprising a glove of liquid impermeable material and a pad of bibulous material impregnated with a blood diagnostic composition capable of undergoing a color change in the presence of blood affixed to the inner surface of the thumb portion of the device in a position contactable by the tip of any of the finger portions thereof.
  • a disposable test device as defined in claim 1 wherein the blood diagnostic composition comprises a peroxidic substance, a solid organic acid and an indicator oxidizable with an accompanying color change in the presence of hemoglobin.

Abstract

A disposable device for testing the contents of accessible body cavities is provided by a glove of impermeable material having a pad of bibulous material impregnated with a test composition affixed to the thumb of the glove in a position contactable by the tip of any of the fingers thereof. The test pad may be affixed either to the base of the thumb of the glove or to the inner surface of the distal end thereof or to both positions. When the pad of bibulous material is impregnated with a blood diagnostic composition the device is useful in the detection of occult blood in accessible body cavities such as the rectum.

Description

United States Patent Ubersax et a1.
[54] DISPOSABLE BLOOD TEST DEVICE [72] Inventors: Richard W. Ubersax, 1921 Greve Avenue, Spring Lake Heights, NJ. 08807; Andrew Truhan, RD. #3, Box 392 T, Somerset, NJ. 08873 [22] Filed: Aug. 17, 1970 [21] Appl.N0.: 64,509
[ June 27, 1972 3,507,269 4/1970 Berry ..128/2 W FOREIGN PATENTS 0R APPLICATIONS 241,199 1/1926 Great Britain 128/2 W 1,018,563 1/1966 Great Britain 128/2 W Primary Examiner-Kyle L. Howell Attorney-Stowe & Stowell [57] ABSTRACT A disposable device for testing the contents of accessible body cavities is provided by a glove of impermeable material having a pad of bibulous material impregnated with a test composition affixed to the thumb ofthe glove in a position contactable by the tip of any of the fingers thereof. The test pad may be affixed either to the base of the thumb of the glove or to the inner surface of the distal end thereof or to both positions. When the pad of bibulous material is impregnated with a blood diagnostic composition the device is useful in the detection of occult blood in accessible body cavities such as the rectum.
4 Claims, 3 Drawing Figures PATENIEDJMT :2 3,672,351
F56. FIG. 2.
ll! ENTORS RICHARD W. UBERSAX ANDREW TRUHAN BY a. {(1
ATTORNEYS DISPOSABLE BLOOD TEST DEVICE The invention relates to a convenient disposable device for testing the contents of accessible body cavities, such as the rectum, in the course of palpation of the body cavity by a physician. Such a device is provided by a glove of impermeable material having a pad of bibulous material impregnated with a test composition affixed to the thumb of the glove in a position contactable by the tip of any of the fingers thereof. The test pad may be affixed either to the base of the thumb or to the inner surface of the distal end thereof or to both positions. In a particularly useful fonn of the invention the test pad is impregnated with a blood diagnostic composition.
The presence of occult blood in the rectal contents may be indicative of gastrointestinal cancer or ulcers or of hemorrhoids and means for rapidly and conveniently detecting thepresence of such blood in the rectal contents without carrying out complicated laboratory procedures is highly desirable. The test device of the invention will be more fully described with reference to its use for the detection of occult blood in body cavity contents.
An illustrative form of the invention is shown in the accompanying drawing in which:
H6. 1 is a representation in palm view of the device of the invention;
FIG. 2 is a representation of the device of the invention as used in testing any substance adhering to a finger tip of the device; and
FIG. 3 is a partial section on line 3-3 of FIG. 2.
In the drawing, 1 is a glove of an impermeable material, such as rubber or other elastic or plastic material and 2 is the impregnated test patch affixed to the external base of the thumb portion of glove 1 or to the distal end thereof as indicated at 2' in dotted lines.
The patch may be made of paper, cloth, felt or other bibulous material, impregnated with a composition activated by the presence of blood to undergo a color change. Suitable compositions for the detection of blood are well known in the art. They include peroxidic substances which release under acidic conditions hydrogen peroxide or other active oxidants and indicator substances oxidizable by the released oxidant to form highly colored reaction products.
Typical peroxidic substances include inorganic compounds, such as peroxides, perborates and persulfates of the alkali and alkaline earth metals and organic peroxides and organic hydroperoxides such as cumenehydroperoxide and diisopropylbenzenehydroperoxide.
Suitable oxidizable dye-forming compounds include benzidine, o-tolidine, o-toluidine, o-phenylene-diamine, N,N dimethyl-p-phenylene-diamine, N,N-diethyl-p-phenylenediamine, p-anisidine, o-cresol, m-cresol, p-cresol, a-naphthol, B-naphthol, catechol, guaiacol and pyrogallol.
The acidic component of the composition is preferably a normally solid, water-soluble organic acid such as citric and oxalic acids.
A typical impregnating composition consists of parts by weight of citric acid, 10 parts by weight of benzidine and 25 parts by weight of barium peroxide. This composition will develop a blue color in the presence of blood hemoglobin.
The test patches may be made by impregnating filter paper with an aqueous solution of the citric acid, drying the paper, impregnating the dried paper with a suspension of the barium peroxide in a chloroform solution of the benzidine and evaporating the chloroform. The dried impregnated paper is cut into patches of suitable size and shape and the patches are afiixed to the base of the thumb portion of rubber gloves with a suitable adhesive, such as rubber cement.
We claim:
1. A disposable test device comprising a glove of liquid impermeable material and a pad of bibulous material impregnated with a blood diagnostic composition capable of undergoing a color change in the presence of blood affixed to the inner surface of the thumb portion of the device in a position contactable by the tip of any of the finger portions thereof.
2. A disposable test device as defined in claim 1 wherein the blood diagnostic composition comprises a peroxidic substance, a solid organic acid and an indicator oxidizable with an accompanying color change in the presence of hemoglobin.
3. A disposable test device as defined in claim 2 wherein the peroxidic substance is an alkaline earth peroxide.
4. A disposable test device as defined in claim 2 wherein the oxidizable indicator is an aryldiamine, a phenol or a naphthol.

Claims (4)

1. A disposable test device comprising a glove of liquid impermeable material and a pad of bibulous material impregnated with a blood diagnostic composition capable of undergoing a color change in the presence of blood affixed to the inner surface of the thumb portion of the device in a position contactable by the tip of any of the finger portions thereof.
2. A disposable test device as defined in claim 1 wherein the blood diagnostic composition comprises a peroxidic substance, a solid organic acid and an indicator oxidizable with an accompanying color change in the presence of hemoglobin.
3. A disposable test device as defined in claim 2 wherein the peroxidic substance is an alkaline earth peroxide.
4. A disposable test device as defined in claim 2 wherein the oxidizable indicator is an aryldiamine, a phenol or a naphthol.
US64509A 1970-08-17 1970-08-17 Disposable blood test device Expired - Lifetime US3672351A (en)

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Cited By (41)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4175923A (en) * 1978-06-26 1979-11-27 Friend William G Method and apparatus for occult blood testing in the home
US4327744A (en) * 1980-06-23 1982-05-04 Smith Louise W Apparatus for the self-collection of cervical cell specimens
US4344439A (en) * 1980-10-20 1982-08-17 Ulrico Jacobellis Catheter for use in localizing the origin of idiopathic microscopic hematuria
US4357945A (en) * 1981-06-01 1982-11-09 Janko Albert B Device for testing and rupturing amniotic membrane
US4473079A (en) * 1982-09-13 1984-09-25 Jasper David A Simple, small, self-contained tests for occult blood
US4541987A (en) * 1983-09-29 1985-09-17 Helena Laboratories Corporation Test pad for detecting occult blood
US4725553A (en) * 1983-09-29 1988-02-16 Helena Laboratories Corporation Test composition for detecting occult blood
US4771482A (en) * 1987-07-17 1988-09-20 Shlenker Robin R T Glove for inhibiting the spread of contagious diseases and method of using the same
WO1989005449A1 (en) * 1987-12-02 1989-06-15 Cukier Daniel S Apparel having a breach indicator
WO1989009567A1 (en) * 1988-04-13 1989-10-19 Endotherapeutics Method of obtaining cervical culture specimens and device and kit therefor
US4910803A (en) * 1987-12-02 1990-03-27 Cukier Daniel S Apparel having a breach indicator
US4919966A (en) * 1987-07-17 1990-04-24 Shlenker Robin R T Covering such as a glove, condom or sheath for inhibiting the spread of contagious diseases and methods of making and using the same
US4935260A (en) * 1987-07-17 1990-06-19 Shlenker Robin R T Covering such as a suit, glove, condum or sheath forming a chemical barrier against harmful agents and methods of making the same
US4956300A (en) * 1982-01-05 1990-09-11 Helena Laboratories Corporation Aid for determining the presence of occult blood, method of making the aid, and method of using the aid
US5064766A (en) * 1989-10-18 1991-11-12 Wardlaw Stephen C Method for differentiating the source of occult gastrointestinal bleeding
US5081040A (en) * 1987-06-29 1992-01-14 Helena Laboratories Corporation Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes
US5196167A (en) * 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5217874A (en) * 1989-04-04 1993-06-08 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5273888A (en) * 1984-01-16 1993-12-28 Helena Laboratories Corporation Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals
US5459879A (en) * 1989-05-22 1995-10-24 Board Of Regents, The University Of Texas System Protective coverings
US5476794A (en) * 1991-03-20 1995-12-19 Thermedics Inc. Detection method for checking surfaces for nitrogen-containing explosives or drugs
US5483697A (en) * 1989-05-22 1996-01-16 Board Of Regents The University Of Texas Multilayer protective coverings with a sealing solution
US5549924A (en) * 1987-07-17 1996-08-27 Robin Renee Thill Shlenker Method of forming a membrane, especially a latex or polymer membrane, including a deactivating barrier and indicating layer
US5582620A (en) * 1995-09-14 1996-12-10 Thomas Jefferson University Radial distention of a soft tissue space using a finger guided distention balloon
US5658723A (en) * 1987-04-03 1997-08-19 Cardiovascular Diagnostics, Inc. Immunoassay system using forced convection currents
US5679399A (en) * 1987-07-17 1997-10-21 Bio Barrier, Inc. Method of forming a membrane, especially a latex or polymer membrane, including multiple discrete layers
US5702913A (en) * 1983-12-21 1997-12-30 Helena Laboratories Corporation Chromgen-reagent test system
US5840584A (en) * 1995-06-07 1998-11-24 Waldenburg; Ottfried Blood in feces test device
US5942186A (en) * 1995-12-22 1999-08-24 Sanada; Hiromi Adhesive plate with indicator function and indicator therefor
US5976881A (en) * 1992-05-28 1999-11-02 Colormetric Laboratories, Inc. Device and method for detecting chemical breakthrough of protective clothing
US6123676A (en) * 1996-05-30 2000-09-26 Selfcare International Method and apparatus for detecting an increased risk of a premature birth
US6309887B1 (en) * 1998-01-27 2001-10-30 Flexsite Diagnostics, Inc. Filter paper treatment for improved diagnostic assays
US20030120180A1 (en) * 2001-12-21 2003-06-26 Kimberly-Clark Worldwide, Inc. Method and apparatus for collecting and testing biological samples
US6867052B2 (en) * 1998-12-22 2005-03-15 Toxin Alert, Inc. Biological material detecting articles of manufacture
GB2425709A (en) * 2005-05-06 2006-11-08 Sonia Papworth A glove
US20090240130A1 (en) * 2008-03-18 2009-09-24 Barnes Sr Albert T Examination Device for Blood Detection
US20100111763A1 (en) * 2008-03-18 2010-05-06 Kahn Laurence H Examination Device for Blood Detection
US20120042429A1 (en) * 2010-08-23 2012-02-23 Zare Marc M Padded glove
US20130098174A1 (en) * 2010-07-13 2013-04-25 Roger Heller Method for measuring particles adhering to a body
US20180073843A1 (en) * 2016-09-09 2018-03-15 Deane Owen Elliott Disposable arrow wipe with chemical indicator
US10436774B1 (en) * 2017-05-16 2019-10-08 Cathy Everett Glove having chromogenic material

Cited By (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4175923A (en) * 1978-06-26 1979-11-27 Friend William G Method and apparatus for occult blood testing in the home
US4327744A (en) * 1980-06-23 1982-05-04 Smith Louise W Apparatus for the self-collection of cervical cell specimens
US4344439A (en) * 1980-10-20 1982-08-17 Ulrico Jacobellis Catheter for use in localizing the origin of idiopathic microscopic hematuria
US4357945A (en) * 1981-06-01 1982-11-09 Janko Albert B Device for testing and rupturing amniotic membrane
US4956300A (en) * 1982-01-05 1990-09-11 Helena Laboratories Corporation Aid for determining the presence of occult blood, method of making the aid, and method of using the aid
US4473079A (en) * 1982-09-13 1984-09-25 Jasper David A Simple, small, self-contained tests for occult blood
US4541987A (en) * 1983-09-29 1985-09-17 Helena Laboratories Corporation Test pad for detecting occult blood
US4725553A (en) * 1983-09-29 1988-02-16 Helena Laboratories Corporation Test composition for detecting occult blood
US5702913A (en) * 1983-12-21 1997-12-30 Helena Laboratories Corporation Chromgen-reagent test system
US5273888A (en) * 1984-01-16 1993-12-28 Helena Laboratories Corporation Chemical test kit and method for determining the presence of blood in a specimen and for verifying the effectiveness of the chemicals
US5658723A (en) * 1987-04-03 1997-08-19 Cardiovascular Diagnostics, Inc. Immunoassay system using forced convection currents
US5081040A (en) * 1987-06-29 1992-01-14 Helena Laboratories Corporation Composition and kit for testing for occult blood in human and animal excretions, fluids, or tissue matrixes
US4935260A (en) * 1987-07-17 1990-06-19 Shlenker Robin R T Covering such as a suit, glove, condum or sheath forming a chemical barrier against harmful agents and methods of making the same
US5549924A (en) * 1987-07-17 1996-08-27 Robin Renee Thill Shlenker Method of forming a membrane, especially a latex or polymer membrane, including a deactivating barrier and indicating layer
US4919966A (en) * 1987-07-17 1990-04-24 Shlenker Robin R T Covering such as a glove, condom or sheath for inhibiting the spread of contagious diseases and methods of making and using the same
US5679399A (en) * 1987-07-17 1997-10-21 Bio Barrier, Inc. Method of forming a membrane, especially a latex or polymer membrane, including multiple discrete layers
US4771482A (en) * 1987-07-17 1988-09-20 Shlenker Robin R T Glove for inhibiting the spread of contagious diseases and method of using the same
US5965276A (en) * 1987-07-17 1999-10-12 Bio Barrier, Inc. Method of forming a membrane especially a latex or polymer membrane including multiple discrete layers
US4910803A (en) * 1987-12-02 1990-03-27 Cukier Daniel S Apparel having a breach indicator
US4843014A (en) * 1987-12-02 1989-06-27 Cukier Daniel S Apparel having a breach indicator
WO1989005449A1 (en) * 1987-12-02 1989-06-15 Cukier Daniel S Apparel having a breach indicator
WO1989009567A1 (en) * 1988-04-13 1989-10-19 Endotherapeutics Method of obtaining cervical culture specimens and device and kit therefor
US4920974A (en) * 1988-04-13 1990-05-01 Endotherapeutics Method of obtaining cervical culture specimens and device and kit therefor
US5217874A (en) * 1989-04-04 1993-06-08 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5196167A (en) * 1989-04-04 1993-03-23 Helena Laboratories Corporation Fecal occult blood test product with positive and negative controls
US5483697A (en) * 1989-05-22 1996-01-16 Board Of Regents The University Of Texas Multilayer protective coverings with a sealing solution
US5459879A (en) * 1989-05-22 1995-10-24 Board Of Regents, The University Of Texas System Protective coverings
US5064766A (en) * 1989-10-18 1991-11-12 Wardlaw Stephen C Method for differentiating the source of occult gastrointestinal bleeding
US5476794A (en) * 1991-03-20 1995-12-19 Thermedics Inc. Detection method for checking surfaces for nitrogen-containing explosives or drugs
US5976881A (en) * 1992-05-28 1999-11-02 Colormetric Laboratories, Inc. Device and method for detecting chemical breakthrough of protective clothing
US5840584A (en) * 1995-06-07 1998-11-24 Waldenburg; Ottfried Blood in feces test device
US5582620A (en) * 1995-09-14 1996-12-10 Thomas Jefferson University Radial distention of a soft tissue space using a finger guided distention balloon
US5942186A (en) * 1995-12-22 1999-08-24 Sanada; Hiromi Adhesive plate with indicator function and indicator therefor
US6123676A (en) * 1996-05-30 2000-09-26 Selfcare International Method and apparatus for detecting an increased risk of a premature birth
US6309887B1 (en) * 1998-01-27 2001-10-30 Flexsite Diagnostics, Inc. Filter paper treatment for improved diagnostic assays
US6867052B2 (en) * 1998-12-22 2005-03-15 Toxin Alert, Inc. Biological material detecting articles of manufacture
US20030120180A1 (en) * 2001-12-21 2003-06-26 Kimberly-Clark Worldwide, Inc. Method and apparatus for collecting and testing biological samples
GB2425709A (en) * 2005-05-06 2006-11-08 Sonia Papworth A glove
GB2425709B (en) * 2005-05-06 2009-11-25 Papworth Sonia One glove bed check
US20090240130A1 (en) * 2008-03-18 2009-09-24 Barnes Sr Albert T Examination Device for Blood Detection
US20100111763A1 (en) * 2008-03-18 2010-05-06 Kahn Laurence H Examination Device for Blood Detection
US7938776B2 (en) 2008-03-18 2011-05-10 Mederistic Solutions, Inc. Examination device for blood detection
US20130098174A1 (en) * 2010-07-13 2013-04-25 Roger Heller Method for measuring particles adhering to a body
US20120042429A1 (en) * 2010-08-23 2012-02-23 Zare Marc M Padded glove
US20180073843A1 (en) * 2016-09-09 2018-03-15 Deane Owen Elliott Disposable arrow wipe with chemical indicator
US10066914B2 (en) * 2016-09-09 2018-09-04 Deane Owen Elliott Disposable arrow wipe with chemical indicator
US10436774B1 (en) * 2017-05-16 2019-10-08 Cathy Everett Glove having chromogenic material

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