US3723613A - Dental plaque disclosing agent - Google Patents

Dental plaque disclosing agent Download PDF

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US3723613A
US3723613A US00109054A US3723613DA US3723613A US 3723613 A US3723613 A US 3723613A US 00109054 A US00109054 A US 00109054A US 3723613D A US3723613D A US 3723613DA US 3723613 A US3723613 A US 3723613A
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plaque
red
blue
composition
fdc
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P Block
J Derdivanis
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q11/00Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/46Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur
    • A61K8/466Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing sulfur containing sulfonic acid derivatives; Salts
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/49Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds
    • A61K8/4973Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom
    • A61K8/498Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing heterocyclic compounds with oxygen as the only hetero atom having 6-membered rings or their condensed derivatives, e.g. coumarin
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N31/00Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods
    • G01N31/22Investigating or analysing non-biological materials by the use of the chemical methods specified in the subgroup; Apparatus specially adapted for such methods using chemical indicators
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/52Use of compounds or compositions for colorimetric, spectrophotometric or fluorometric investigation, e.g. use of reagent paper and including single- and multilayer analytical elements
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/40Chemical, physico-chemical or functional or structural properties of particular ingredients
    • A61K2800/42Colour properties
    • A61K2800/43Pigments; Dyes

Definitions

  • This invention relates to novel disclosing agents for use in the improvement of oral hygiene practices. More specifically the invention pertains to combinations of dyes; FDC Red No. 3 and FDC Blue No. l; FDC Red No. 3 and FDC Green No. 3; FDC Red No. 3 and Hercules Green Shade 3 for employment as disclosing agents in the control of dental plaque.
  • Dental plaque is a well-organized structure which forms on tooth surfaces and restorations. It consists mainly of bacteria surrounded by a matrix derived primarily from saliva and the bacteria themselves. Plaque differs from other soft tooth deposits such as materia alba and food debris in that it has a definite architecture and cannot be flushed away by rinsing with water.
  • plaques can be made vital and important to the patient by visualization whereby every patient is shown his plaque in situ and under the phase contrast microscope. The patient may also observe the diseased gingival areas and their juxtaposition to the places of plaque accumulation. These visual demonstrations serve two main purposes. First, it shows the patient that he does indeed have these dangerous bacterial deposits called plaques on his teeth. Secondly, by microscopic visualization, he sees that those innocent looking masses are composed of millions of living bacteria of differing shapes; some even having the ability to move about. Experience has shown that the technique of visualization of plaque generates in patients a true interest in plaque, and an abvious and apparent concern for its prompt removal.
  • plaque Since plaque is translucent or tooth-colored, it is necessary that it be appropriately stained in color for it to be made visible.
  • Disclosing dyes have been in use for over 50 years. Many substances have been used, e.g. iodine, basic fuchsin neutral red, etc. Some dyes previously tried by the prior art could not be used because they were suspected carcinogens, others appeared in the urine, and taste was a drawback to many materials.
  • red disclosing dye reveals that red is the wrong color since plaque that has been stained red is extremely difficult to see due to poor contrast with the oral tissues, especially in the back areas of the mouth and between the teeth. It should be noted that it is these precise areas which are the most prevelant sites of caries and periodontal disease.
  • a disclosing agent having all the desirable properties of the current red media, but possessing, however, a color which would be in sharp contrast to the gingival tissues would vastly improve the effectiveness of such a product.
  • the continuing search for an improved disclosing dye preparation has led to the development of the blue dye medium of the invention which provides a two-tone dye test for dental plaque.
  • novel dyes of the invention not only stain plaque a color which contrasts well with the tissues and teeth, thus making plaque visible even in the hard to see places, but they possess the property of selective differential staining and thereby permit a distinction to be made between areas of old thick accumulations and thin recent deposits. It has been well documented in dental literature that it is thick plaque deposits which are generally associated with periodontal'disease and exhibit the anaerobic flora seen in periodontal pockets. In other words, thick old plaques are probably more pathogenic than the new deposits.
  • the novel dyes of the invention are unique in that by color alone the third dimension of plaque, its age and thickness, can be readily estimated. Thick plaques stain blue and thin plaques stain red. Since old and new plaques have their own characteristic microbial morphology, the bacterial types can be also judged by color differentiation using the dyes of the invention. Utilizing the novel two-tone dye test for dental plaque the patient can, for the first time, judge for himself whether he has been practicing effective plaque removal by noting whether any plaque deposits which may be stained are either red or blue. If he consistently misses certain areas they will be considerably thicker and therefore stained blue. If he has been doing a thorough and effective job of plaque control, he will either show no stain pickup or if he has thin deposits they will stain red.
  • the dentist can also use this dye test to obtain virtually a quantitative evaluation of the effectiveness of the patients plaque control.
  • the dyes are a useful tool in dental research.
  • the extremely important third dimension of plaque its thickness can be noted by color differential and this information recorded in a photograph.
  • Studies that have been conducted heretofore to evaluate the effectiveness of antiplaque agents and oral hygiene aids using the prior art erythrosine have failed to convey the information about plaque thickness.
  • blue plaque shows the following clinical and microscopic features:
  • This intermediate area tended to look more like blue plaque than red plaque but the thickness of this plaque was less than that of blue plaque.
  • the dyes of the invention find particular value as research and diagnostic tools. They can be used in evaluating antiplaque agents, or plaque control techniques and devices by providing vital information about the third dimension of plaque, its thickness. Prior. art disclosing dyes have not been able to supply this information, thus severely limiting the value of those studies conducted to measure the effectiveness of plaque removal.
  • the relative ratio of one dye to the other in formulat ing the dye compositions of the invention is not critical and the unobvious two-tone properties may be achieved by employing for each part by weight of FDC Red No. 3 from about 0.1 to about 4 parts by weight of either FDC Green No. 3, FDC Blue No. 1 or Hercules Green Shade 3.
  • a preferred ratio would involve one to two parts by weight of the latter for each part by weight of FDC Red No. 3.
  • the concentration of the dye is not critical and may vary from about 600 to 1,200 mg. per 100 ml. of solution. If one desires to utilize the dyes as tablets or wafers, the amount of dye included in each tablet or wafer is not critical and may vary from about 20 mg. to about 100 mg. per dosage unit.
  • FDC Red No. 3 A representative example of a combination of FDC Red No. 3 and FDC Green No. 3 that may be used in the practice of the invention is as follows:
  • the formulation is painted on the teeth and gingiva, retained a few seconds and rinsed off with a small amount of water. Newly formed plaque stains red whereas old plaque stains deep blue or purple.
  • the manner by which the dye is made available to the mouth area is not critical and will vary according to patient acceptance and convenience.
  • the novel dye in addition to painting on the teeth the novel dye can be formulated as a chewable tablet, wafer, powder, lozenges, aerosol, liquid concentrate, etc.
  • Lactose Lactose, spray dried .855 Flavoring oils, spray dried in gelatin .020 Magnesium stearate .014 FDC Red No. 3 .020 FDC Green No. 3 .040 Saccharin .001 Citric acid a .050
  • Fluid Preparation May be painted on full strength, or diluted with water for use as a rinse) by weight Ethanol, USP 15.00 Polysorbate 0.20 Flavoring oils 0.50 Glycerin 5.00 FDC Red No. 3 .25 FDC Blue No. l .50 Water, q.s. ad 100.00
  • a composition comprising for each part by weight of FDC Red No. 3, from about 0.1 to 4 parts by weight of a dye selected from the group consisting of FDC Blue No. l, FDC Green No.
  • Hercules Green Shade 3 said composition adapted to differentially stain areas of old, thick accumulations of dental plaque deep blue or purple and thin, recent deposits of dental plaque red, whereby effectively practiced plaque removal on a given tooth shows, and can be photographed, as either no stain pickup or thin deposits staining red, while certain areas on said tooth if consistently missed, will be considerably thicker and therefore stained blue, and on some teeth, an intermediate definite purple zone can be distinguished between the red and blue areas, said intermediate definite purple area tending to look more like blue plaque than red plaque, but the thickness of this purple plaque being less than that of blue plaque, while tooth surfaces not covered with plaque do not show the dye at all.
  • the improvement comprising applying to the oral cavity a composition comprising for each part by weight of FDC Red No. 3, from about l2 parts by weight of a dye selected from the group consisting of FDC Blue No. 1, FDC Green No.
  • Hercules Green Shade 3 said composition adapted to differentially stain areas of old, thick accumulations of dental plaque deep blue or purple and thin, recent deposits of dental plaque red, whereby effectively practiced plaque removal on a given tooth shows, and can be photographed, as either no stain pickup or thin deposits staining red, while certain areas on said tooth if consistently missed, will be considerably thicker and therefore stained blue, and on some teeth, an intermediate definite purple zone can be distinguished between the red and blue areas, said intermediate definite purple area tending to look more like blue plaque than red plaque, but the thickness of this purple plaque being less than that of blue plaque, close examination of said photographs revealing p aque colonies growing on a tooth surface displaying a central raised blue mass surrounded by a red and/or purple peripheral zone which was lower than the central mass, the red zone of adjacent plaque colonies tending to fuse forming red fields peppered with blue raised areas, while tooth surfaces not covered with plaque do not show the dye at all, said composition by color alone enabling the estimation of the third dimension of plaque, its age, and

Abstract

Disclosing agent for use in control of dental plaque. The agents are compositions comprises of FDC Red No. 3 and FDC Blue No. 1; FDC Red No. 3 and FDC Green No. 3 and FDC Red No. 3 and Hercules Green Shade 3.

Description

Elnified Siaies Pafient [191 Block et al. Mar. 27, 1973 [54] DENTAL PLAQUE DISQLOSING [56] References Cited AGENT UNITED STATES PATENTS [76] Inventors: Philip L. Block, 416 Deerfield Dr.,
g J P- 1 Bender Derdlvams, 6284 Crown Ave., Primary Examiner shep K. Rose Oakland, Calif. 94600 Attorney-Townsend & Townsend [22] Filed: Jan. 22, 1971 211 App]. No.: 109,054 [57] ABSTRACT Disclosing agent for use in control of dental plaque. The agents are compositions comprises of FDC Red [52] US. Cl. NO. 3 and FDC Blue No. 1; FDC Red NO 3 and FDC G N.3 dFDCRdN.3 dH 1 5 l] 1mm. .001 31/00, 00111 33/16 S3: 3 o e o an es Green [58] Field of Search ..424/7, 9, 3
10 Claims, No Drawings DENTAL lLAQUE DISCLOSING AGENT This invention relates to novel disclosing agents for use in the improvement of oral hygiene practices. More specifically the invention pertains to combinations of dyes; FDC Red No. 3 and FDC Blue No. l; FDC Red No. 3 and FDC Green No. 3; FDC Red No. 3 and Hercules Green Shade 3 for employment as disclosing agents in the control of dental plaque.
Dental plaque is a well-organized structure which forms on tooth surfaces and restorations. It consists mainly of bacteria surrounded by a matrix derived primarily from saliva and the bacteria themselves. Plaque differs from other soft tooth deposits such as materia alba and food debris in that it has a definite architecture and cannot be flushed away by rinsing with water.
It is well established that dental plaque plays a major role in the etiology of periodontal diseases and caries. Although the exact manner in which plaque contributes to these disease states is not known at present, it is appreciated that effective and thorough removal of these deposits is absolutely essential for oral health. Accordingly it is desirable that an effective plaque control program be established as part of the treatment plan for every dental patient. For this program to be effective the patient must be motivated to carry out thorough daily plaque control techniques. Motivation can be achieved, however, only by establishing goals that are meaningful and attainable by the patient. Experience has shown that most patients would not be sufficiently motivated to practice good oral hygiene if they were simply told that plaque is a bacterial colony growing on their teeth; that plaque produces gingival disease and carries and must be removed daily. However, the entire concept of what plaque is and what it does to tissue can be made vital and important to the patient by visualization whereby every patient is shown his plaque in situ and under the phase contrast microscope. The patient may also observe the diseased gingival areas and their juxtaposition to the places of plaque accumulation. These visual demonstrations serve two main purposes. First, it shows the patient that he does indeed have these dangerous bacterial deposits called plaques on his teeth. Secondly, by microscopic visualization, he sees that those innocent looking masses are composed of millions of living bacteria of differing shapes; some even having the ability to move about. Experience has shown that the technique of visualization of plaque generates in patients a true interest in plaque, and an abvious and apparent concern for its prompt removal.
Since plaque is translucent or tooth-colored, it is necessary that it be appropriately stained in color for it to be made visible. Disclosing dyes have been in use for over 50 years. Many substances have been used, e.g. iodine, basic fuchsin neutral red, etc. Some dyes previously tried by the prior art could not be used because they were suspected carcinogens, others appeared in the urine, and taste was a drawback to many materials.
Since its development in 1963, a disclosing tablet containing FDC No. 3 as the staining agent has been widely employed as a disclosing agent to stain plaque. One of the reasons the dye was so widelyaccepted was because it met the criteria established at that time for an effective disclosing medium; namely, that it should have a pleasing shade of red. However, with regular use of the FDC Red No. 3 tablet, it became abundantly clear that the pleasing shade of red adversely affected the utility of the wafer. The plaque interprox imally and at the gingival margin, especially in the posterior areas, could not easily be seen because of poor contrast between the gingiva and the stained plaque. Accordingly, the use of a red disclosing dye reveals that red is the wrong color since plaque that has been stained red is extremely difficult to see due to poor contrast with the oral tissues, especially in the back areas of the mouth and between the teeth. It should be noted that it is these precise areas which are the most prevelant sites of caries and periodontal disease.
A disclosing agent having all the desirable properties of the current red media, but possessing, however, a color which would be in sharp contrast to the gingival tissues would vastly improve the effectiveness of such a product. The continuing search for an improved disclosing dye preparation has led to the development of the blue dye medium of the invention which provides a two-tone dye test for dental plaque.
The novel dyes of the invention not only stain plaque a color which contrasts well with the tissues and teeth, thus making plaque visible even in the hard to see places, but they possess the property of selective differential staining and thereby permit a distinction to be made between areas of old thick accumulations and thin recent deposits. It has been well documented in dental literature that it is thick plaque deposits which are generally associated with periodontal'disease and exhibit the anaerobic flora seen in periodontal pockets. In other words, thick old plaques are probably more pathogenic than the new deposits.
The novel dyes of the invention are unique in that by color alone the third dimension of plaque, its age and thickness, can be readily estimated. Thick plaques stain blue and thin plaques stain red. Since old and new plaques have their own characteristic microbial morphology, the bacterial types can be also judged by color differentiation using the dyes of the invention. Utilizing the novel two-tone dye test for dental plaque the patient can, for the first time, judge for himself whether he has been practicing effective plaque removal by noting whether any plaque deposits which may be stained are either red or blue. If he consistently misses certain areas they will be considerably thicker and therefore stained blue. If he has been doing a thorough and effective job of plaque control, he will either show no stain pickup or if he has thin deposits they will stain red.
The dentist can also use this dye test to obtain virtually a quantitative evaluation of the effectiveness of the patients plaque control.
Additionally, the dyes are a useful tool in dental research. For the first time the extremely important third dimension of plaque, its thickness can be noted by color differential and this information recorded in a photograph. Studies that have been conducted heretofore to evaluate the effectiveness of antiplaque agents and oral hygiene aids using the prior art erythrosine have failed to convey the information about plaque thickness.
In the following study patients were selected at random and their teeth were stained with a representative dye of the invention (FDC Red No. 3 and FDC Green No. 3). Kodachromes were taken of these stained areas from which plaque was to be removed for microscopic examination. At all times plaque samples were taken from teeth that showed red and blue plaque on the same tooth. This was done to eliminate any variation in plaque bacterial morphology that could exist between one tooth and another. Each plaque colony was disected with the tip of a fine curette. The samples were placed on a slide, suspended .in Ringers Solution, and examined and photographed through a phase contrast microscope at 400 X and 1000 X. According to the invention it is now possible to distinguish between old thick plaque and new thin plaque based on the distinctive color each takes with the novel dye of the invention.
Generally, blue plaque shows the following clinical and microscopic features:
1. Considerably greater thickness than red plaque.
2. High degree of architectural organization. Cocci, rods and/or filaments arranged in parallel rows forming fan-shaped patterns. These rays were perpendicular to the tooth but this pattern was broken at the time of sample removal.
. Filaments intertwined forming a mesh work.
. Motility present in some blue plaques.
. Spiral organisms and vibrios. Red plaques are distinguished by the following:
. Extreme thinness to the extent that sometimes it was hard to obtain sufficient material for examination.
. Low density of organisms.
. No evidence of any orderly architecture.
No motility.
No filaments, spiral organisms or vibrios. On some teeth treated with the dye it was also possible to distinguish an intermediate zone between the red and blue areas that had a definite purple color.
This intermediate area tended to look more like blue plaque than red plaque but the thickness of this plaque was less than that of blue plaque.
Close examination of the Kodachromes revealed some interesting facts. Plaque colonies growing on a tooth surface displayed a central raised blue mass surrounded by a red and/Cr purple peripheral zone which was lower than the central mass. The red zones of adjacent colonies tended' to fuse forming red fields peppered with blue raised areas. Those tooth surfaces that were not covered with plaque did not show the dye at all. It should be noted that patients treated with the dye do-not find the blue color objectionable or the taste unpalatable. The blue color fades quickly from teeth, restorations and tissues with simple water rinses and brushing. In addition, stains are easily removed from laundry or plumbing fixtures.
The dyes of the invention find particular value as research and diagnostic tools. They can be used in evaluating antiplaque agents, or plaque control techniques and devices by providing vital information about the third dimension of plaque, its thickness. Prior. art disclosing dyes have not been able to supply this information, thus severely limiting the value of those studies conducted to measure the effectiveness of plaque removal.
The relative ratio of one dye to the other in formulat ing the dye compositions of the invention is not critical and the unobvious two-tone properties may be achieved by employing for each part by weight of FDC Red No. 3 from about 0.1 to about 4 parts by weight of either FDC Green No. 3, FDC Blue No. 1 or Hercules Green Shade 3. A preferred ratio would involve one to two parts by weight of the latter for each part by weight of FDC Red No. 3.
Where the dye is to be used in the form of a solution, the concentration of the dye is not critical and may vary from about 600 to 1,200 mg. per 100 ml. of solution. If one desires to utilize the dyes as tablets or wafers, the amount of dye included in each tablet or wafer is not critical and may vary from about 20 mg. to about 100 mg. per dosage unit.
A representative example of a combination of FDC Red No. 3 and FDC Green No. 3 that may be used in the practice of the invention is as follows:
FDC Red No. 3 200 mg. FDC Green No. 3 400 mg. Surfactant between 20) 0.1 ml. Tap water 60 ml.
The formulation is painted on the teeth and gingiva, retained a few seconds and rinsed off with a small amount of water. Newly formed plaque stains red whereas old plaque stains deep blue or purple.
The manner by which the dye is made available to the mouth area is not critical and will vary according to patient acceptance and convenience. For example, in addition to painting on the teeth the novel dye can be formulated as a chewable tablet, wafer, powder, lozenges, aerosol, liquid concentrate, etc.
Examples directed to the preparation of such formulations are as follows:
Chewable Tablets or Wafers Grams .905 Flavoring oils, spray dried in gum acacia .025 Calcium stearate .010 FDC Red No. 3 .020 FDC Green No. 3 .040
Lactose, spray dried .855 Flavoring oils, spray dried in gelatin .020 Magnesium stearate .014 FDC Red No. 3 .020 FDC Green No. 3 .040 Saccharin .001 Citric acid a .050
Fluid Preparation (May be painted on full strength, or diluted with water for use as a rinse) by weight Ethanol, USP 15.00 Polysorbate 0.20 Flavoring oils 0.50 Glycerin 5.00 FDC Red No. 3 .25 FDC Blue No. l .50 Water, q.s. ad 100.00
Aerosol Sprays by weight Gl cerin 15.0 Et anol, absolute 43.4 Saccharin 0.] Flavor 0.2 Propellant 12 16.0 Propellant 114 25.0 FDC Red No. 3 0.1 FDC Green No. 3 0.1
Ethanol, USP
Glycerin 5 00 Flavoring oils 0.35 FDC Red No. 3 0.25 FDC Green No.3 0.50 Water 68.90 Propellant 12 100.00
Lozenges Grams Corn syrup solids, spray dried .880 Flavoring oils, spray dried with modified starch 0.050 Calcium stearate .010 FDC Red No. 3 .020 Hercules Green Shade 3 .040 1.000
What is claimed is:
1. In a process for the differential disclosure of dental plaque, the improvement comprising applying to the oral cavity a composition comprising for each part by weight of FDC Red No. 3, from about 0.1 to 4 parts by weight of a dye selected from the group consisting of FDC Blue No. l, FDC Green No. 3 and Hercules Green Shade 3, said composition adapted to differentially stain areas of old, thick accumulations of dental plaque deep blue or purple and thin, recent deposits of dental plaque red, whereby effectively practiced plaque removal on a given tooth shows, and can be photographed, as either no stain pickup or thin deposits staining red, while certain areas on said tooth if consistently missed, will be considerably thicker and therefore stained blue, and on some teeth, an intermediate definite purple zone can be distinguished between the red and blue areas, said intermediate definite purple area tending to look more like blue plaque than red plaque, but the thickness of this purple plaque being less than that of blue plaque, while tooth surfaces not covered with plaque do not show the dye at all.
2. A process in accordance with claim 1 wherein said dye is FDC Green No.3.
3. A process in accordance with claim 1 and further characterized by a minor amount of surfactant being included in said composition.
4. A process in accordance with claim 1 wherein said composition is aqueous.
5. A process in accordance with claim 1 wherein said composition is in tablet form.
6. A process in accordance with claim 1 wherein said composition is in aerosol spray form.
'7. In a process for the differential disclosure of dental plaque, the improvement comprising applying to the oral cavity a composition comprising for each part by weight of FDC Red No. 3, from about l2 parts by weight of a dye selected from the group consisting of FDC Blue No. 1, FDC Green No. 3 and Hercules Green Shade 3, said composition adapted to differentially stain areas of old, thick accumulations of dental plaque deep blue or purple and thin, recent deposits of dental plaque red, whereby effectively practiced plaque removal on a given tooth shows, and can be photographed, as either no stain pickup or thin deposits staining red, while certain areas on said tooth if consistently missed, will be considerably thicker and therefore stained blue, and on some teeth, an intermediate definite purple zone can be distinguished between the red and blue areas, said intermediate definite purple area tending to look more like blue plaque than red plaque, but the thickness of this purple plaque being less than that of blue plaque, close examination of said photographs revealing p aque colonies growing on a tooth surface displaying a central raised blue mass surrounded by a red and/or purple peripheral zone which was lower than the central mass, the red zone of adjacent plaque colonies tending to fuse forming red fields peppered with blue raised areas, while tooth surfaces not covered with plaque do not show the dye at all, said composition by color alone enabling the estimation of the third dimension of plaque, its age, and thickness.
8. A process in accordance with claim 7 wherein said composition is aqueous.
9. A process in accordance with claim 7 wherein said composition is in tablet form.
10. A process in accordance with claim 7 wherein said composition is in aerosol spray form.

Claims (9)

  1. 2. A process in accordance with claim 1 wherein said dye is FDC Green No. 3.
  2. 3. A process in accordance with claim 1 and further characterized by a minor amount of surfactant being included in said composition.
  3. 4. A process in accordance with claim 1 whereIn said composition is aqueous.
  4. 5. A process in accordance with claim 1 wherein said composition is in tablet form.
  5. 6. A process in accordance with claim 1 wherein said composition is in aerosol spray form.
  6. 7. In a process for the differential disclosure of dental plaque, the improvement comprising applying to the oral cavity a composition comprising for each part by weight of FDC Red No. 3, from about 1-2 parts by weight of a dye selected from the group consisting of FDC Blue No. 1, FDC Green No. 3 and Hercules Green Shade 3, said composition adapted to differentially stain areas of old, thick accumulations of dental plaque deep blue or purple and thin, recent deposits of dental plaque red, whereby effectively practiced plaque removal on a given tooth shows, and can be photographed, as either no stain pickup or thin deposits staining red, while certain areas on said tooth if consistently missed, will be considerably thicker and therefore stained blue, and on some teeth, an intermediate definite purple zone can be distinguished between the red and blue areas, said intermediate definite purple area tending to look more like blue plaque than red plaque, but the thickness of this purple plaque being less than that of blue plaque, close examination of said photographs revealing plaque colonies growing on a tooth surface displaying a central raised blue mass surrounded by a red and/or purple peripheral zone which was lower than the central mass, the red zone of adjacent plaque colonies tending to fuse forming red fields peppered with blue raised areas, while tooth surfaces not covered with plaque do not show the dye at all, said composition by color alone enabling the estimation of the third dimension of plaque, its age, and thickness.
  7. 8. A process in accordance with claim 7 wherein said composition is aqueous.
  8. 9. A process in accordance with claim 7 wherein said composition is in tablet form.
  9. 10. A process in accordance with claim 7 wherein said composition is in aerosol spray form.
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Cited By (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903252A (en) * 1972-06-08 1975-09-02 Lorvic Corp Dental disclosing compositions and the method of making and using the same
US4150106A (en) * 1978-02-16 1979-04-17 Cooper S.A. Toothpaste permitting of controlling the tooth brushing time
DE2948575A1 (en) * 1978-12-04 1980-06-12 Kuraray Co CARIES DETECTOR PREPARATION
WO1981000513A1 (en) * 1979-08-20 1981-03-05 J Thorel New compositions for detecting dental plaque
US4302439A (en) * 1976-04-07 1981-11-24 Selwyn Stephen L Method of disclosing dental plaque with D and C Red 33
US4348378A (en) * 1979-08-09 1982-09-07 Kosti Carl M Plaque disclosing dentifrice compositions with semi-solid microcapsules of dye
US4431628A (en) * 1978-04-07 1984-02-14 Colgate-Palmolive Company Natural dye indicator for dental plaque
US4459277A (en) * 1980-10-07 1984-07-10 Kosti Carl M Plaque disclosing dentifrice compositions with solid microcapsules of dye
WO1990003162A1 (en) * 1988-09-23 1990-04-05 Frank Hunter Improvements in oral hygiene
AU644062B2 (en) * 1988-09-23 1993-12-02 Frank Hunter Improvements in oral hygiene
US5862559A (en) * 1988-09-23 1999-01-26 Hunter; Frank Toothbrush for interproximal and periodontal pocket cleaning
US20020095072A1 (en) * 2001-01-17 2002-07-18 Drug Enhancement Company Of America, Llc Combination and method including a visual marker for determining compliance with a medication regimen
WO2004054528A1 (en) * 2002-12-18 2004-07-01 Hager & Werken Gmbh & Co. Kg Staining agent in tablet form for making visible the formation of dental plaque and method for producing such a tinting agent
US20050058602A1 (en) * 2003-09-11 2005-03-17 The Procter & Gamble Company Dye composition and method for detection of demineralized lesions in teeth
US20060104922A1 (en) * 2003-05-21 2006-05-18 Tarver J G Tooth whitening compositions and methods for using the same
US20070086960A1 (en) * 2003-05-21 2007-04-19 Tarver J G Systems and methods for enhancing the appearance of teeth
WO2009087626A2 (en) 2008-01-08 2009-07-16 Sharon Lerner Microbes detecting and treating toothbrush
JP2015527410A (en) * 2012-09-11 2015-09-17 エスエルエイチ オプティマル ヘルス エルエルシーSlh Optimal Health Llc Teeth cleaning composition
CN106821529A (en) * 2017-02-28 2017-06-13 厦门罗雅光科技有限公司 Portable dental check device and its control method

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Cited By (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3903252A (en) * 1972-06-08 1975-09-02 Lorvic Corp Dental disclosing compositions and the method of making and using the same
US4302439A (en) * 1976-04-07 1981-11-24 Selwyn Stephen L Method of disclosing dental plaque with D and C Red 33
US4150106A (en) * 1978-02-16 1979-04-17 Cooper S.A. Toothpaste permitting of controlling the tooth brushing time
US4431628A (en) * 1978-04-07 1984-02-14 Colgate-Palmolive Company Natural dye indicator for dental plaque
DE2948575A1 (en) * 1978-12-04 1980-06-12 Kuraray Co CARIES DETECTOR PREPARATION
US4347233A (en) * 1978-12-04 1982-08-31 Kuraray Company, Limited Dental caries detection
US4348378A (en) * 1979-08-09 1982-09-07 Kosti Carl M Plaque disclosing dentifrice compositions with semi-solid microcapsules of dye
WO1981000513A1 (en) * 1979-08-20 1981-03-05 J Thorel New compositions for detecting dental plaque
US4459277A (en) * 1980-10-07 1984-07-10 Kosti Carl M Plaque disclosing dentifrice compositions with solid microcapsules of dye
WO1990003162A1 (en) * 1988-09-23 1990-04-05 Frank Hunter Improvements in oral hygiene
AU644062B2 (en) * 1988-09-23 1993-12-02 Frank Hunter Improvements in oral hygiene
US5862559A (en) * 1988-09-23 1999-01-26 Hunter; Frank Toothbrush for interproximal and periodontal pocket cleaning
US20020095072A1 (en) * 2001-01-17 2002-07-18 Drug Enhancement Company Of America, Llc Combination and method including a visual marker for determining compliance with a medication regimen
US20060235312A1 (en) * 2001-01-17 2006-10-19 Pediamed Pharmaceuticals, Inc. Combination and method including a visual marker for determining compliance with a medication regimen
US7062312B2 (en) * 2001-01-17 2006-06-13 Pediamed Pharmaceuticals, Inc. Combination and method including a visual marker for determining compliance with a medication regimen
US7479268B2 (en) * 2002-12-18 2009-01-20 Hager & Werken Gmbh & Co. Kg Staining agent in tablet form for making visible the formation of dental plaque and method for producing such a staining agent
US20050214214A1 (en) * 2002-12-18 2005-09-29 Heiko Krantz Staining agent in tablet form for making visible the formation of dental plaque and method for producing such a tinting agent
WO2004054528A1 (en) * 2002-12-18 2004-07-01 Hager & Werken Gmbh & Co. Kg Staining agent in tablet form for making visible the formation of dental plaque and method for producing such a tinting agent
US20070086960A1 (en) * 2003-05-21 2007-04-19 Tarver J G Systems and methods for enhancing the appearance of teeth
US20060104922A1 (en) * 2003-05-21 2006-05-18 Tarver J G Tooth whitening compositions and methods for using the same
US20050058602A1 (en) * 2003-09-11 2005-03-17 The Procter & Gamble Company Dye composition and method for detection of demineralized lesions in teeth
WO2009087626A2 (en) 2008-01-08 2009-07-16 Sharon Lerner Microbes detecting and treating toothbrush
US20100296859A1 (en) * 2008-01-08 2010-11-25 Sharon Lerner Microbes Detecting and Treating Toothbrush
US8636433B2 (en) 2008-01-08 2014-01-28 Sharon Lerner Microbes detecting and treating toothbrush
JP2015527410A (en) * 2012-09-11 2015-09-17 エスエルエイチ オプティマル ヘルス エルエルシーSlh Optimal Health Llc Teeth cleaning composition
US9999686B2 (en) 2012-09-11 2018-06-19 Slh Optimal Health Llc Dental cleaning composition
CN106821529A (en) * 2017-02-28 2017-06-13 厦门罗雅光科技有限公司 Portable dental check device and its control method

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