WO1992002206A1 - Lyophilized native collagen sheets comprising cosmetic formulations for the treatment of couperose - Google Patents

Lyophilized native collagen sheets comprising cosmetic formulations for the treatment of couperose Download PDF

Info

Publication number
WO1992002206A1
WO1992002206A1 PCT/EP1991/001404 EP9101404W WO9202206A1 WO 1992002206 A1 WO1992002206 A1 WO 1992002206A1 EP 9101404 W EP9101404 W EP 9101404W WO 9202206 A1 WO9202206 A1 WO 9202206A1
Authority
WO
WIPO (PCT)
Prior art keywords
concentration
couperose
treatment
collagen sheets
collagen
Prior art date
Application number
PCT/EP1991/001404
Other languages
French (fr)
Inventor
Virgilio Vitali
Annalisa Rovesti
Original Assignee
Arval S.P.A.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arval S.P.A. filed Critical Arval S.P.A.
Publication of WO1992002206A1 publication Critical patent/WO1992002206A1/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/676—Ascorbic acid, i.e. vitamin C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/02—Cosmetics or similar toiletry preparations characterised by special physical form
    • A61K8/0208—Tissues; Wipes; Patches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/60—Sugars; Derivatives thereof
    • A61K8/602—Glycosides, e.g. rutin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/63—Steroids; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
    • A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67—Vitamins
    • A61K8/673—Vitamin B group
    • A61K8/675—Vitamin B3 or vitamin B3 active, e.g. nicotinamide, nicotinic acid, nicotinyl aldehyde
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00—Cosmetics or similar toiletry preparations
    • A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783—Angiosperms [Magnoliophyta]
    • A61K8/9789—Magnoliopsida [dicotyledons]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00—Preparations for care of the skin
    • A61Q19/08—Anti-ageing preparations

Definitions

  • the present invention concerns lyophilized native collagen sheets containing cosmetic formulations useful for the treatment of a skin aesthetic problem known as couperose.
  • Couperose is a reddening condition of the face skin due to impaired venous cutaneous microcirculation.
  • the conventional cosmetic treatments of couperose even though functional, do not give results comparable to those obtained with the topical administration of specific substances lyophilized in the form of a sheet together with the native collagen.
  • lyophilized native collagen sheets containing special active ingredients can be advantageously used for the treatment of couperose.
  • the active ingredients that can be used according to the present invention preferably include horse-chestnut extracts, goldenseal extracts, rutine, hirudine, ascorbic acid.
  • other active principles of natural or synthetic origin can be used, endowed with properties equivalent or similar to those, of the mentioned substances, or having anyhow an activity which is considered useful for the treatment of couperose.
  • Horse-chestnut and goldenseal extracts are known for their anti-essudative and anti-oedematous properties. Rutine is known for its anti-spasmodic and capillary-protecting activity. Hirudine, the anti ⁇ coagulant principle of leech's saliva (Hirudo edicinalis) exerts a regenerative and tonic action on the capillary walls, and it is endowed with anti- inflammatory properties. Nicotinamide is an essential element in many cellular processes, whereas ascorbic acid is known for its anti-oxidizing and anti-free radical properties. Finally, aescine is the active ingredient of horse-chestnut extract and it is known for its anti-oedematous and capillary-protective properties.
  • these substances will be used, preferably but not necessarily, in combination, in order to reach a special effectiveness of cosmetic treatment.
  • the collagen sheet according to the invention can be obtained according to conventional techniques, by lyophilizing native collagen in the presence of said substances.
  • the collagen sheets of the present invention can contain from about 0.1% to 20% in weight of the above mentioned substances; the collagen sheets will preferably contain from 0.1 to 5% of horse-chestnut of goldenseal extract, from 0.1 to 2% of rutine; from 1 to 10% of hirudine; from 0.1 to 3% of nicotinamide; from 0.1 to 5% of ascorbic acid; from 0.1 to 5% of aescine.
  • the collagen sheets according to the invention will contain from 1 to 3% of horse-chestnut and goldenseal extract; from 0.2 to 1% of rutine; from 0.5 to 1.5% of aescine; from 0.5 to 2% of nicotinamide; from 1 to 3% of hirudine; from 0.5 to 2% of ascorbic acid. 5
  • the collagen sheets according to the invention when applied daily in the form of a mask, or on alternate day for 10-15 consecutive days, allow a specific and functional treatment of couperose, allowing individual and objective results definitely

Abstract

Lyophilized native collagen sheets containing a formulation for the treatment of couperose, comprising one or more of the substances selected from horse-chestnut extract, goldenseal extract, rutine, hirudine, nicotinamide, aescine, ascorbic acid.

Description

LYOPHILIZED NATIVE COLLAGEN SHEETS COMPRISING COSMETIC FORMULATIONS FOR THE TREATMENT OF COϋPEROSE
The present invention concerns lyophilized native collagen sheets containing cosmetic formulations useful for the treatment of a skin aesthetic problem known as couperose. Couperose is a reddening condition of the face skin due to impaired venous cutaneous microcirculation. The conventional cosmetic treatments of couperose, even though functional, do not give results comparable to those obtained with the topical administration of specific substances lyophilized in the form of a sheet together with the native collagen.
The use of lyophilized native collagen is very common in cosmetics for the treatment of wrinkles, stretch marks or other aesthetic problems of the skin. It has now been found, and it is the object of the present invention, that lyophilized native collagen sheets containing special active ingredients can be advantageously used for the treatment of couperose. The active ingredients that can be used according to the present invention preferably include horse-chestnut extracts, goldenseal extracts, rutine, hirudine, ascorbic acid. However, other active principles of natural or synthetic origin can be used, endowed with properties equivalent or similar to those, of the mentioned substances, or having anyhow an activity which is considered useful for the treatment of couperose.
Horse-chestnut and goldenseal extracts are known for their anti-essudative and anti-oedematous properties. Rutine is known for its anti-spasmodic and capillary-protecting activity. Hirudine, the anti¬ coagulant principle of leech's saliva (Hirudo edicinalis) exerts a regenerative and tonic action on the capillary walls, and it is endowed with anti- inflammatory properties. Nicotinamide is an essential element in many cellular processes, whereas ascorbic acid is known for its anti-oxidizing and anti-free radical properties. Finally, aescine is the active ingredient of horse-chestnut extract and it is known for its anti-oedematous and capillary-protective properties.
According to the invention, these substances will be used, preferably but not necessarily, in combination, in order to reach a special effectiveness of cosmetic treatment. The collagen sheet according to the invention can be obtained according to conventional techniques, by lyophilizing native collagen in the presence of said substances.
Native collagen sheets and their preparation are described in US 4412947, EP 0284789, FR 2328786.
The collagen sheets of the present invention can contain from about 0.1% to 20% in weight of the above mentioned substances; the collagen sheets will preferably contain from 0.1 to 5% of horse-chestnut of goldenseal extract, from 0.1 to 2% of rutine; from 1 to 10% of hirudine; from 0.1 to 3% of nicotinamide; from 0.1 to 5% of ascorbic acid; from 0.1 to 5% of aescine. More preferably, the collagen sheets according to the invention will contain from 1 to 3% of horse-chestnut and goldenseal extract; from 0.2 to 1% of rutine; from 0.5 to 1.5% of aescine; from 0.5 to 2% of nicotinamide; from 1 to 3% of hirudine; from 0.5 to 2% of ascorbic acid. 5 The collagen sheets according to the invention, when applied daily in the form of a mask, or on alternate day for 10-15 consecutive days, allow a specific and functional treatment of couperose, allowing individual and objective results definitely
10 better than conventional treatments. A quantitative composition of a collagen sheet according to the present invention is reported hereinbelow by way of example.
EXAMPLE
15 Formulation native collagen collagen support hirudine polypeptides ascorbic acid
20 horse-chestnut glycole extract goldenseal fluid extract (ED = 1.25:1) rutine aescine
25 nicotinamide
Carrier
Figure imgf000005_0001
30 100.00

Claims

1. Lyophilized native collagen sheets containing a formulation for the treatment of couperose, comprising one or more of the substances selected from horse- chestnut extract, goldenseal extract, rutine, hirudine, nicotinamide, aescine, ascorbic acid.
2. Collagen sheets according to claim 1, containing from 0.1 to 20% of said substances.
3. Collagen sheets according to claim 1 or 2, wherein horse-chestnut and goldenseal extracts are present in a concentration ranging from 0.1 to 5%; rutine in a concentration ranging from 0.1 to 2%; hirudine in a concentration ranging from 1 to 10%; nicotinamide in a concentration ranging from 0.1 to 3%; aescine in a concentration ranging from 0.1 to 5%; ascorbic acid in a concentration ranging from 1 to 5%.
4. Collagen sheets according to claim 1, wherein horse-chestnut and goldenseal extracts are present in a concentration of 1.5 and 2%, respectively; rutine in a concentration of 0.5%; hirudine in a concentration of 2.5%; nicotinamide in a concentration of 0.7%; aescine in a concentration of 0.8%; ascorbic acid in a concentration of 1%.
5. Native collagen mixed with biocompatible substances of natural or synthetic origin for cosmetic use.
6. Collagen according to claim 5 in the form of lyophilized sheets having a thickness from 0.5 to 5 mm.
PCT/EP1991/001404 1990-08-03 1991-07-26 Lyophilized native collagen sheets comprising cosmetic formulations for the treatment of couperose WO1992002206A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT02118690A IT1243196B (en) 1990-08-03 1990-08-03 LYOPHILIZED NATIVE COLLAGEN SHEETS CONTAINING COSMETIC FORMULAS FOR THE TREATMENT OF COUPEROSE
IT21186A/90 1990-08-03

Publications (1)

Publication Number Publication Date
WO1992002206A1 true WO1992002206A1 (en) 1992-02-20

Family

ID=11178082

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1991/001404 WO1992002206A1 (en) 1990-08-03 1991-07-26 Lyophilized native collagen sheets comprising cosmetic formulations for the treatment of couperose

Country Status (3)

Country Link
AU (1) AU8235291A (en)
IT (1) IT1243196B (en)
WO (1) WO1992002206A1 (en)

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0577143A2 (en) * 1992-07-03 1994-01-05 ALFATEC-PHARMA GmbH Solid and liquid solutions of flavonoids
WO1999047116A1 (en) * 1998-03-16 1999-09-23 The Procter & Gamble Company Skin care compositions
US6183761B1 (en) 1998-03-16 2001-02-06 The Procter & Gamble Company Compositions for regulating skin appearance
WO2002043691A1 (en) * 2000-11-29 2002-06-06 Provincia Italiana Della Congregazione Dei Figli Dell'immacolata Concezione - Istituto Dermopatico Dell'immacolata Skin cream stimulating the surface bloodstream
FR2843304A1 (en) * 2002-08-07 2004-02-13 Ricarimpex Stable complex of destabilase, useful in pharmaceuticals and cosmetics, especially for coating cardiovascular stents, is isolated from leeches as liposomal polymeric aggregate

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4412947A (en) * 1979-09-12 1983-11-01 Seton Company Collagen sponge
EP0094285A1 (en) * 1982-05-07 1983-11-16 Elf Sanofi Preparation based on lyophilized native collagen and its use in the cosmetic field

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4412947A (en) * 1979-09-12 1983-11-01 Seton Company Collagen sponge
EP0094285A1 (en) * 1982-05-07 1983-11-16 Elf Sanofi Preparation based on lyophilized native collagen and its use in the cosmetic field

Cited By (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0577143A2 (en) * 1992-07-03 1994-01-05 ALFATEC-PHARMA GmbH Solid and liquid solutions of flavonoids
EP0577143A3 (en) * 1992-07-03 1994-09-21 Alfatec Pharma Gmbh Solid and liquid solutions of flavonoids
WO1999047116A1 (en) * 1998-03-16 1999-09-23 The Procter & Gamble Company Skin care compositions
US6183761B1 (en) 1998-03-16 2001-02-06 The Procter & Gamble Company Compositions for regulating skin appearance
WO2002043691A1 (en) * 2000-11-29 2002-06-06 Provincia Italiana Della Congregazione Dei Figli Dell'immacolata Concezione - Istituto Dermopatico Dell'immacolata Skin cream stimulating the surface bloodstream
FR2843304A1 (en) * 2002-08-07 2004-02-13 Ricarimpex Stable complex of destabilase, useful in pharmaceuticals and cosmetics, especially for coating cardiovascular stents, is isolated from leeches as liposomal polymeric aggregate
WO2004015096A2 (en) * 2002-08-07 2004-02-19 Ricarimpex Leech extracts for stents
WO2004015096A3 (en) * 2002-08-07 2004-04-08 Ricarimpex Leech extracts for stents

Also Published As

Publication number Publication date
IT9021186A0 (en) 1990-08-03
AU8235291A (en) 1992-03-02
IT9021186A1 (en) 1992-02-03
IT1243196B (en) 1994-05-24

Similar Documents

Publication Publication Date Title
US5785978A (en) Skin care compositions and methods
US5968533A (en) Skin care compositions and methods
US5425954A (en) Topical amino acid - vitamin complex compositions for pharmaceutical and cosmetic use
US4424232A (en) Treatment of herpes simplex
CA2105313A1 (en) Therapeutic and cosmetic compositions for treatment of skin
KR20000026159A (en) Method for stabilizing an ascorbic acid, its derivatives and/or extract containing ascorbic acid for local application
AU3232789A (en) Anesthetic skin moisturizing composition and method of preparing same
US4054649A (en) Therapeutic compositions and the treatment of lesions of connective tissue
WO1992015276A2 (en) Therapeutic and cosmetic compositions for treatment of skin
CA2431651A1 (en) Antifungal nail composition and method of use
US4034114A (en) Treatment of skin keratoses with retinal
WO1992002206A1 (en) Lyophilized native collagen sheets comprising cosmetic formulations for the treatment of couperose
KR20080030773A (en) Cosmetic composition for anti-wrinkle
JPH0348165B2 (en)
WO1994005272A1 (en) Skin treatment compositions containing dimethylsulphone and dimethylsulphoxide
AU781964B2 (en) Non-solid composition for local application
AU629445B2 (en) Improvements in or relating to topical compositions containing 1 alpha 25-dihydroxycholecalciferol
EP0105448B1 (en) The use of undecylenic acid for the manufacture of a composition for the treatment of herpes labialis
WO1994005279A1 (en) Dermatological treatment compositions containing dimethylsulphone and a sulfur containing amino acid
ES2182840T3 (en) FACTOR XIII FOR THE TREATMENT OF SKIN WOUNDS.
US20050276766A1 (en) Methods and compositions for increasing skin remodeling
US5977176A (en) Compositions for the treatment of warts and herpes
US5576005A (en) Effectiveness of wart removal by compositions including propolis
KR880005920A (en) Leukocyte interferon composition and skin treatment in the human body
JP3516792B2 (en) External preparation for skin

Legal Events

Date Code Title Description
AK Designated states

Kind code of ref document: A1

Designated state(s): AU BB BG BR CA CS FI HU JP KP KR LK MC MG MN MW NO PL RO SD SU US

AL Designated countries for regional patents

Kind code of ref document: A1

Designated state(s): AT BE BF BJ CF CG CH CI CM DE DK ES FR GA GB GN GR IT LU ML MR NL SE SN TD TG

NENP Non-entry into the national phase

Ref country code: CA