WO1993001862A1 - Treatment of respiratory disorders by nerve stimulation - Google Patents

Treatment of respiratory disorders by nerve stimulation Download PDF

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Publication number
WO1993001862A1
WO1993001862A1 PCT/US1992/005980 US9205980W WO9301862A1 WO 1993001862 A1 WO1993001862 A1 WO 1993001862A1 US 9205980 W US9205980 W US 9205980W WO 9301862 A1 WO9301862 A1 WO 9301862A1
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WO
WIPO (PCT)
Prior art keywords
patient
waveform
vagus nerve
respiratory
activity
Prior art date
Application number
PCT/US1992/005980
Other languages
French (fr)
Inventor
Joachim F. Wernicke
Reese S. Terry, Jr.
Original Assignee
Cyberonics, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cyberonics, Inc. filed Critical Cyberonics, Inc.
Priority to EP92915788A priority Critical patent/EP0600916A4/en
Publication of WO1993001862A1 publication Critical patent/WO1993001862A1/en

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Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61NELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N1/00Electrotherapy; Circuits therefor
    • A61N1/18Applying electric currents by contact electrodes
    • A61N1/32Applying electric currents by contact electrodes alternating or intermittent currents
    • A61N1/36Applying electric currents by contact electrodes alternating or intermittent currents for stimulation
    • A61N1/3601Applying electric currents by contact electrodes alternating or intermittent currents for stimulation of respiratory organs

Definitions

  • the present invention relates generally to methods and apparatus for treating or controlling medical, psychiat- ric or neurological disorders by application of modulating electrical signals to a selected nerve or nerves of the pa ⁇ tient, and more particularly to techniques for treating patients with respiratory disorders by application of such signals to a cranial nerve, using an implantable neurostimul- ating device.
  • the invention is directed toward treating various respiratory disorders, such as asthma, apnea, and cystic fibrosis by selective modulation of vagus nerve electrical activity.
  • asthma As a disease entity, asthma is usually idiopathic - - with attacks commonly precipitated by allergic reactions. The attacks are characterized by continuous or paroxysmal labored breathing accompanied by wheezing and a sense of constriction in the chest, and often by coughing or gasping. Apnea is a transient cessation of respiration. Sleep apneas are characterized by brief episodes of respiratory arrest, which may occur many times during sleep and may be associated with obstruction of the upper airways, cessation of diaphrag ⁇ matic movements and snoring. Cystic fibrosis (CF) is a hereditary disease characterized in part by abnormal secre- tion in the lungs, leading to difficulty in breathing.
  • CF cystic fibrosis
  • Certain of the respiratory disorders are commonly treated using various drugs and medications.
  • asthma is treated with theopholine, bronchosol, and/or ste ⁇ roids.
  • stimulants such as amphetamines are usually adminstered.
  • CF infec ⁇ tions such as pneumonia which are common with CF are treated with antibiotics, and such treatment may be used prophylacti- cally.
  • these forms of treatment have not been very effective in all cases, and may cause undesirable side- effects. It is a principal object of the present invention to apply techniques of selective modulation of the electrical activity of a cranial nerve, and particularly the vagus nerve, to treat and control various respiratory disorders, including asthma, apnea, and cystic fibrosis.
  • the nerves in the human body are generally composed of thousands of fibers of different sizes designated groups A, B and C, which carry signals to and from the brain and other parts of the body.
  • the vagus nerve may have approximately 100,000 fibers (axons) of the three different types, each of which carries such signals. Each axon of that nerve only conducts in one direction, in normal circumstances.
  • the A and B fibers are myelinated (i.e., each has a myelin sheath composed largely of fat)
  • the C fibers are unmyelinated.
  • myelinated fibers are larger, conduct electrical signals faster, and are electri ⁇ cally stimulated at much lower thresholds than unmyelinated fibers.
  • Such fibers exhibit a particular strength-duration curve in response to a specific width and amplitude of stimulation pulse.
  • the A and B fibers are stimulated with relatively narrow pulse widths, from 50 to 200 microseconds ( ⁇ s) , for example.
  • a fibers exhibit slightly faster electrical conduc ⁇ tivities than the B fibers, and slightly lower electrical stimulation thresholds.
  • the C fibers are relatively much smaller, conduct electrical signals very slowly, and have high stimulation thresholds typically requiring wider pulse widths (e.g., 300-1000 ⁇ s) and higher amplitudes for activa ⁇ tion.
  • the A and B fibers may be selectively stimulated without also stimulating the C fibers, the magnitude and width of the pulse required for stimulating the C fibers would also activate A and B fibers.
  • vagus nerve is composed of somatic and visceral afferents (i.e., inward conducting nerve fibers which convey impulses toward a nerve center such as the brain or spinal cord) and efferents (i.e., outward conducting nerve fibers which convey impulses to an effector to stimulate it and produce activity) .
  • vagal nerve fibers The vast majority of vagal nerve fibers are C fibers, and a majority are visceral afferents having cell bodies lying in masses or ganglia in the neck.
  • the central projections terminate largely in the nucleus of the solitary tract which sends fibers to various regions of the brain (e.g, the hypothala- mus, thalamus, and amygdala) ; others continue to the medial reticular formation of the medulla, the cerebellum, the nucleus cuneatus and other regions.
  • Woodbury further notes that stimulation of vagal nerve afferent fibers in animals evokes detectable changes of the EEG in all of these regions, and that the nature and extent of these EEG changes depends on the stimulation parameters.
  • Extra-physiologic electrical stimulation of the vagus nerve has previously been proposed for treatment of epilepsy and various forms of involuntary movement disorders.
  • U.S. Patent 4,702,254 to J. Zabara referred to herein as "the '254 patent”
  • a method and implantable device are disclosed for alleviating or preventing epileptic seizures, characterized by abnormal neural discharge patterns of the brain.
  • the *254 patent describes an implantable neurocybernetic prosthesis (NCP) which utilizes neurocyb- emetic spectral discrimination by tuning the external current of the NCP generator to the electrochemical proper ⁇ ties of a specific group of inhibitory nerves that affect the reticular system of the brain.
  • NCP implantable neurocybernetic prosthesis
  • the spectral discrimina ⁇ tion analysis dictates that certain electrical parameters of the NCP pulse generator be selected based on the electrochem ⁇ ical properties of the nerves desired to be activated.
  • the patent further indicates that the optimum sites for applica- tion of the NCP generator output to produce the desired effects are the cranial nerves in general, and the vagus nerve in particular.
  • the NCP disclosed in the '254 patent may be activated manually or automatically to provide treatment for the duration of the seizure.
  • Manual activation is performed when the patient experiences the aura at onset of the seizure.
  • automatic activation may be trig ⁇ gered upon detection of instantaneous changes in certain state parameters immediately preceding or at onset of a seizure.
  • a prophylactic or preventive mode may be employed in which the NCP is activated periodically to reduce the occurrence and/or the intensity of the seizures.
  • the NCP stimulator of the *254 patent is implanted in the patient's chest and is connected to electrodes installed at the selected point of signal application at the nerve site with the more negative electrode situated closer to the brain and the positive electrode further from the brain, along the vagus nerve.
  • vagus nerve One of the functions of the vagus nerve is to monitor and modulate the diameter of the bronchi.
  • Morrison et al. reported, in Br. J. Pharmacol. (1989) 28:545-549, that patients with asthma have increased vagal activity, leading to increased bronchomotor tone, especially at night; and that increased vagal activity, rather than increased receptor sensitivity, was believed to be the cause for this phenome ⁇ non.
  • Apnea may be induced by any of a variety of known causes, including degenerative diseases of the brain, and brain tumors; or may be idiopathic in origin. The condition is thought to be related to sleep disorders that vary in severity from adult snoring to sudden infant death syndrome. Abnormal control of respiration may lead to apnea.
  • CF is characterized by an excessive quantity of abnormally viscous secretions. These secretions occlude the bronchi, leading to respiratory distress and pneumonia. Since vagal activity is involved in control of bronchial tone, modulation of vagal activity may be useful in increas ⁇ ing bronchial diameter, making it easier to clear secretions.
  • the invention resides in methods and apparatus for treating respiratory disorders such as asthma, apnea and cystic fibrosis by vagal modulation.
  • the apparatus comprises a neurostimulator for generating electrical pulses in a programmable pattern to produce the desired modulation of vagal electrical activity.
  • asthma is treated by inhibiting vagal activity to increase bronchial diameter.
  • Apnea can be treated by stimulating the vagus nerve, to increase the respiratory rate.
  • the neuro- stimulator which modulates the electrical activity of the vagus nerve be activated by a sensor adapted to detect cessation of breathing.
  • patient activation of the neurostimulator is preferable for asthma sufferers, because the patient can readily detect an attack and act accordingly.
  • CF involves abnormal secretions in the lungs.
  • the therapeutic modality employed for this disor ⁇ der is to inhibit the vagus nerve to increase bronchial diameter.
  • the neurostimulator would operate on a continuous cycle in such a manner as to maintain maximum bronchial diameter or to alternately lead to normal and increased diameter. The latter mode would allow for clearing of accumulated secre ⁇ tions.
  • Activation by the patient may also be desirable to treat acute episodes of respiratory distress.
  • vagal stimulation is usually associated with activation, parameters can likely be found for effective blocking of efferent activity.
  • vagus nerve provides feedback to the brain which results in modulation of respiration, it is further postulated that stimulation of the vagus nerve can beneficially treat or control apnea.
  • the applicants have disclosed techniques for treating and controlling sleep apneas by vagal stimulation.
  • the aspect of the present invention involving apneas is closely related to the latter, but is intended for control of apnea occurring when the patient is fully awake but incapable of exercising conscious control because of respiratory abnormality or failure.
  • the apparatus of the invention includes a neuro ⁇ stimulator (preferably but not necessarily implantable) to selectively apply the desired therapy to treat the respirato ⁇ ry disorder of interest by modulating the electrical activity of the patient's vagus nerve in a predetermined manner.
  • the neurostimulator is programmed by the attending physician to provide the desired therapeutic modality for that purpose. Selection among various strategies for vagal modulation to treat the respiratory disorder of interest depends on a number of factors.
  • these include (i) a consid ⁇ eration of which of the nerve fibers are to be subjected to stimulation; (ii) whether synchronization or desynchroniz- ation of the EEG may be desirable, and in either case, the modality for achieving it; (iii) whether some type of physio ⁇ logic signal is generated which can be detected and employed to trigger the modulation; and/or (iv) whether a "carryover" or refractory period occurs after modulation in which the benefit of the modulation is maintained.
  • these are not all of the factors to be considered for selecting a stimulation strategy for treatment of the disorder, nor necessarily listed in order of importance, they are indica- tive of considerations which may apply in a specific case.
  • different signal parameters and threshold curves are used to activate the various fibers of the patient's vagus nerve for selective modulation of the electrical activity thereof.
  • the nerve fibers can be selec ⁇ tively stimulated, such as A and not B and C; or A and B, but not C; or A, B and C.
  • Various related factors must be considered in the selection process. For example, because the C fibers conduct signals very slowly, they are not highly responsive to techniques of fast stimulation.
  • EEG synchronization Proper designation of amplitude and frequency range of the applied signals allows tuning of the fibers for EEG synchronization or desynchronization, for control of the disorder.
  • Desynchronization of the EEG has been found to be achieved by stimulation of the vagus nerve at frequencies in the range from 20 to 75 Hz at levels above 0.1 volt, but requires signals greater than 3 volts at frequencies above 75 Hz. If the frequency is above 75 Hz and the signal is below 3 volts, EEG synchronization is achieved. The actual voltage required depends on the type and geometry of the electrode and the impedance of the electrode-tissue interface.
  • the basic stimulation strategy to control asthma or to treat CF is to decrease the electrical activity of the vagus nerve and thereby decrease bronchomotor tone.
  • Stimulation may be delivered continuously or intermittently on a prede ⁇ termined (preprogrammed) schedule so as to keep the bronchi dilated or to intermittently dilate them.
  • vagal activity is stimulated to produce an immediate increase in the respiratory rate upon detection of cessation of respira ⁇ tory muscle (chest) movement or of air flow through the nostril(s) .
  • a stimulation strategy which does not require specific detection involves the use of circadian or other rhythmic programming to automatically activate vagal stimula ⁇ tion in a manner to eliminate respiratory problems, particu- larly during the normal nighttime cycle.
  • a detec ⁇ tion strategy may be implemented in each case appropriate to the disorder of interest selected to initiate the proper stimulation strategy.
  • the present invention is directed to apparatus and methods which employ a neurostimulator device, preferably implantable, for therapy or treatment of respira ⁇ tory disorders through nerve stimulation.
  • the modulating signals applied to the vagus nerve may stimulate or inhibit neural signals to produce excitatory or inhibitory neuro- transmitter release, but for purposes of this disclosure both situations are included within the term "stimulating".
  • the preferred nerve site for application of the modulating signals is the vagus nerve
  • effective treatment may be achieved through application of the stimulus to one or more other nerves, particularly among the cranial nerves, and such treatment is deemed to be within the ambit of the present invention.
  • a more specific object of the invention is to provide methods and apparatus responsive to detected symptoms characteristic of or associated with certain respiratory disorders for applying preprogrammed electrical stimuli to a cranial nerve and particularly the vagus nerve of the patient to modulate the electrical activity of selected nerve fibers as part of a therapy designed to treat or control the disorder.
  • Another object of the invention is to provide methods of treating and controlling a respiratory disorder by sensing a symptom of the disorder and automatically or manually responding thereto by modulating electrical activity of the patient's vagus nerve.
  • FIG. 1 is a simplified block diagram of an implant ⁇ able neurostimulator (stimulus generator) for use (with appropriate parameter settings and ranges) in treating respiratory disorders according to the present invention
  • FIG. 2 is a simplified fragmentary illustration of a preferred embodiment and location of the generator and lead/electrode system of the neurostimulator implanted in the patient's body, and also illustrating the type and placement of suitable sensing devices associated with the neurostimu ⁇ lator for detecting respiratory disorder attacks;
  • FIG. 3 is a detailed fragmentary illustration of the nerve electrode as implanted on the vagal nerve in the neck of the patient for modulating vagal activity;
  • FIG. 4 is an illustrative idealized electrical output signal waveform of the stimulus generator useful for clarifying relevant parameters of the signal developed by the stimulus generator for application to the nerve.
  • FIG. 1 a block diagram of the basic components of the stimulus generator of a neurosti ⁇ mulator and their interrelationship is illustrated in FIG. 1, and further details of location of.an implantable version of the device and the associated lead/electrode system are shown in FIGS. 2 and 3.
  • FIGS. 2 and 3 A generally suitable form of neurostimu- lator for use in the apparatus of the present invention is disclosed in copending U.S. patent application Ser. No. 07/434,985, filed November 10, 1989 in the names of Anthony J. Varrichio, et al. (referred to herein as "the '985 application”) , assigned to the same assignee as the instant application.
  • the neurostimulator utilizes a conventional microprocessor and other standard electrical and electronic components, and in the case of an implanted device, communi ⁇ cates with a programmer and/or monitor located external to the patient's body by asynchronous serial communication for controlling or indicating states of the device. Passwords, handshakes and parity checks are employed for data integrity.
  • the neurostimulator also includes means for conserving energy, which is important in any battery operated device and especially so where the device is implanted for medical treatment of a disorder, and means for providing various safety functions such as preventing accidental reset of the device.
  • the stimulus generator 10 (FIG. 1) is preferably adapted to be implantable in the patient's body, in a pocket formed by the surgeon just below the skin in the chest as shown in FIG. 2, although a primarily external neurostimu ⁇ lator may alternatively be employed.
  • the neurostimulator also includes implantable stimulating electrodes (described below) together with a lead system 22 for applying the output signal of the stimulus generator to the patient's vagus nerve.
  • Components external to the patient's body include a programming wand for telemetry of parameter changes to the stimulus generator and monitoring signals from the generator, and a computer and associated software for adjustment of parameters and control of communication between the genera ⁇ tor, the programming wand and the computer. These external components of the system are not shown in the drawings.
  • the stimulus generator 10 or other implanted or external circuitry may include detection circuitry for sensing onset or ongoing presence of the respiratory disorder of interest to trigger automatic delivery of the stimulating signal, as will be discussed presently.
  • detection circuitry for sensing onset or ongoing presence of the respiratory disorder of interest to trigger automatic delivery of the stimulating signal, as will be discussed presently.
  • manual activation of the neurostimulator by the patient is the preferred detection strategy, provided that the patient is capable of recognizing and promptly reacting to the disorder.
  • the stimulus genera ⁇ tor is designed, implemented and programmed to deliver a selectively patterned stimulating signal to modulate the electrical activity of the vagus nerve in a manner designed to treat and control the disorder. As shown in FIG.
  • stimulus generator 10 includes a battery (or set of batteries) 12, which may be of any reliable long-lasting type conventionally employed for powering implantable medical electronic devices (such as batteries employed in implantable cardiac pacemakers or defibrillators) .
  • the battery is a single lithium thionyl chloride cell.
  • the terminals of the cell 12 are connected to the input side of a voltage regulator 13.
  • the regulator smoothes the battery output to produce a clean, steady output voltage, and provides enhancement thereof such as voltage multiplica ⁇ tion or division if necessary for a specific application.
  • Regulator 13 supplies power to logic and control section 15, which includes a microprocessor and controls the programmable functions of the device.
  • program- able functions are output current or voltage, output signal frequency, output signal pulse width, output signal on-time, output signal off-time, daily treatment time for continuous or periodic modulation of vagal activity, and output signal- start delay time.
  • Such programmability allows the output signal to be Selectively crafted for application to the stimulating electrode set (FIGS. 2 and 3) to obtain the desired modulation of vagal activity for treatment and control of the specific respiratory disorder.
  • Timing signals for the logic and control functions of the generator are provided by a crystal oscillator 16.
  • a magnetically-actuated reed switch 14 is incorporated in the electronics package to provide the generator with the capability for patient activation thereof (by use of an external magnet, not shown, placed immediately adjacent to the package or its implant site) .
  • Built-in antenna 17 enables communication between the implanted stimulus generator and the external electronics (including both programming and monitoring devices) to permit the device to receive programming signals for parameter changes, and to transmit telemetry information, from and to the programming wand. Once the system is programmed, it operates continuously at the programmed settings until they are reprogrammed (by the attending physician) by means of the external computer and the programming wand.
  • Logic and control section 15 of the stimulus generator 10 controls an output circuit or section 19 which generates the programmed signal levels appropriate to the disorder being treated.
  • the output section and its pro ⁇ grammed output signal are coupled (directly, capacitively, or inductively) to an electrical connector 20 on the housing 21 of the generator and to lead assembly 22 connected to the stimulating electrodes (FIGS. 2 and 3).
  • a sense signal analysis circuit 23 is provided within the generator housing 21, with connections to the microprocessor in logic and control section 15 and to sensing electrodes, if used.
  • the parameters of the stimulating signal of the implanted device may be calibrated by telemetry (via the programming wand) according to the needs of the particular patient and the results then programmed into the microprocessor for delivery of the appropriate treatment upon activation of the stimulus generator.
  • Housing 21 in which stimulus generator 10 is encased is hermetically sealed and composed of a suitable conventional material such as titanium which is biologically compatible with the fluids and tissue of the patient's body. Further details of structure and operation of the neurostimu ⁇ lator, beyond those by which the device is adapted to treat the disorder described herein, are available in the '985 application, to which the reader is referred.
  • FIG. 2 illustrates the preferred location of implanted generator 10, in case 21 with connector 20, in the patient's chest in a cavity formed by the implanting surgeon just below the skin, much as a pacemaker pulse generator would be implanted.
  • a stimulating nerve electrode set 25 (FIG. 3) is conductively connected to the distal end of insulated electrically conductive lead assembly 22 which is attached at its proximal end to connector 20.
  • Electrode set 25 is a bipolar stimulating electrode, preferably of the type described in U.S. Patent 4,573,481 issued March 4, 1986 to Bullara.
  • the electrode assembly is surgically implanted on the vagus nerve 27 in the patient's neck.
  • the two electrodes 25-1 and 25-2 are wrapped about the vagus nerve, and the assembly is secured to the nerve by a spiral anchoring tether 28 preferably as disclosed in U.S. Patent 4,979,511 issued December 25, 1990 to Reese S. Terry, Jr. and assigned to the same assignee as the instant application.
  • Lead(s) 22 is secured, while retaining the ability to flex with movement of the chest and neck, by a suture connection 30 to nearby tissue.
  • the open helical design of electrode assembly 25 (described in detail in the above-cited Bullara patent) , which is self-sizing and flexible, minimizes mechanical trauma to the nerve and allows body fluid interchange with the nerve.
  • the electrode assembly conforms to the shape of the nerve, providing a low stimulation threshold by allowing a larger stimulation contact area.
  • the electrode assembly comprises two ribbons of platinum consti ⁇ tuting the electrodes which are individually bonded to the inside surface of each of the first two spiral loops 25-1 and 25-2 of a three-loop helical assembly, and the two lead wires are respectively welded to the conductive ribbon electrodes.
  • the remainder of each loop is composed of silicone rubber, and the third loop acts as the tether 28 for the electrode assembly.
  • the inner diameter of the helical bipolar elec ⁇ trode assembly may typically be approximately two millimeters (mm) , and an individual spiral is about seven mm long (measured along the axis of the nerve) .
  • a suitable breathing sensor merely detects the presence or absence of nasal air flow and is worn in or near one nostril.
  • Processing of the nasal air flow signal is performed by a suitable external circuit 53 (or internal signal analysis circuit 23) which is adapted to generate an activation command to the microprocessor of logic and control circuit 15.
  • a suitable processing/analysis circuit is an RF signal generator which is adapted to be triggered by a sus ⁇ tained absence of nasal air flow for a predetermined interval of time.
  • a totally implanted sensing system may be employed, if desired, for example using a device which senses movement of the patient's diaphragm associated with normal breathing.
  • the diaphragm movement is sensed by an impedance detector, or alternatively, by plural electrodes for detecting physical movement of the muscle, implanted in the chest of the patient as shown generally at 60 in FIG. 2.
  • the detector generates a signal indicative of absence of diaphra movement for a time interval set accord- ing to the above-mentioned criteria, which is conveyed by implanted lead 62 to trigger application of vagal stimulation by generator 10 under the command of the microprocessor when it determines a lack of movement.
  • the detector may process the signal and send a trigger signal with absence of movement.
  • the stimulus generator may be programmed with an IBM-compatible personal computer (not shown) using program- ming software of the type copyrighted by the assignee of the instant application with the Register of Copyrights, Library of Congress, or other suitable software based on the descrip ⁇ tion herein, and a programming wand (not shown) .
  • the wand and software permit noninvasive communication with the generator after the latter is implanted.
  • the wand is preferably powered by internal batteries, and provided with a "power on" light to indicate sufficient power for communi ⁇ cation. Another indicator light is preferably provided to show that data transmission is occurring between the wand and the generator.
  • stimulus generator 10 to control and treat respiratory disorders utilizes the signal parame ⁇ ters shown in FIG. 4, which is an idealized representation of the output signal waveform delivered by output section 19 of the neurostimulator to electrode assembly 25.
  • This illustra ⁇ tion is presented principally to clarify terminology, including the parameters of output signal on-time, output signal off-time, output signal frequency, output signal pulse width, and output signal current or voltage.
  • the stimulation strategy is to decrease the pat ⁇ ient's vagal activity and thereby decrease the bronchomotor tone, especially at night.
  • the detection strategy for automatic activation of the neurostimulator to that end is to sense either air flow or the amount of vagal activity in a manner which will be discussed in greater detail presently.
  • the patient suffering from asthma or cystic fibrosis is provided with the capability to manually activate the neurostimulator when the onset of an attack is sensed. This is readily accomplished by placing an external magnet directly over the site of the implanted stimulus generator to actuate the reed switch 14 (FIG. 1) .
  • a technique for initiating stimulation without a detection system, either machine sensor or patient sensing, is to program the neurostimulator for activation according to the circadian rhythm of the particular patient and the disorder being treated.
  • the stimulus generator may be programmed to generate its pulses with the selected parameters at one or more set times during the night.
  • automatic detection and stimulation may be employed during the patient's normal sleeping hours, and biased off during the day to require manual activation in that portion of the 24-hour cycle.
  • apnea is treated by stimulating the vagus nerve to increase the respiratory rate upon automatic detection of sustained cessation of breathing.
  • Air flow or chest movement sensors of the types described above with reference to FIG. 2 are preferred.
  • the stimulation strategy involves programming the neurostimulator to desynchronize the apnea patient's EEG activity upon such detection, and thereby increase respiration.
  • the parameters of the stimulus signal may be programmed, for example, at a frequency of 20 Hz, an output current of 1.5 mA, and a pulse width of 0.5 ms for the pulse waveform.
  • a suitable range of stimulation parameters for desynchronization of the patient's EEG activity, and the typical value of each parameter of the stimulating output signal for treatment of apnea are set forth in Table II: TABLE II Range Typical
  • a technique for initiating stimulation without a specific detection system is to program the neurostimulator according to the circadian rhythm of the particular apnea patient, or intermittently, to desynchronize the patient's EEG activity as appropriate.
  • a secondary mode of stimulation for treating apnea patients which may be employed either as an alternative or as an adjunct to the previously described operation, is to apply a painful stimulus such as a mild electric shock to the patient either at the end of the initial time interval with no breathing or after a subsequent shorter time interval indicative of no response by the patient to the normal pulse stimuli from the neurostimulator.
  • the purpose here is to bring the patient back to consciousness and thereby restore breathing through conscious control.
  • Various features may be incorporated into the neurostimulator for purposes of the saf ty and comfort of the patient. For example, comfort is enhanced by programming the output stimulus to ramp up during the first two seconds of stimulation, rather than to be delivered abruptly.
  • the implanted generator may be provided with a clamping circuit to limit the maximum voltage delivered to the vagus nerve (for example, to 14 volts) . The maximum limit is set to prevent injury or trauma to the patient's vagus nerve.
  • the programmable functions and capabilities of the neurostimulator are designed and implemented to permit noninvasive communication with the stimulus generator after it is implanted, which is useful for both activation and monitoring functions.
  • the programming software may readily be structured to provide straightforward menu-driven operation, HELP func ⁇ tions, prompts, and messages to facilitate simple and rapid programming while keeping the user fully informed of every- thing occurring at each step of a sequence.
  • Programming capabilities should include capability to modify the adjust ⁇ able parameters of the stimulus generator and its output signal, to test device diagnostics, and to store and retrieve telemetered data.
  • the present state of the adjustable parameters is displayed on the monitor of external PC so that the programmer may then conveniently change any or all of those parameters at the same time; and, if a particular parameter is selected for change, all permissible values for that parameter are displayed so that the programmer (typical ⁇ ly, limited to the attending physician) may select an appropriate desired value for entry into the neurostimulator.
  • Diagnostics testing should be implemented to verify proper operation of the device, and to indicate the existence of problems such as with communication, the battery, or the lead/electrode impedance. A low battery reading, for example, would be indicative of imminent end of life of the battery and need for implantation of a new device.
  • the nerve electrodes are capable of indefinite use absent indication of a problem with them observed on the diagnostics testing.
  • a totally implantable neurostimulator device need not be utilized.
  • the electronic energization package may be primarily external to the body, and stimulation achieved with an RF power device implemented to provide the necessary energy level.
  • the implanted components may be limited to the lead/electrode assembly, a coil and a DC rectifier, and pulses programmed with the desired parameters transmitted through the skin with an RF carrier. The signal is rectified to regenerate a pulsed signal for application as the stimulus to the vagus nerve to modulate vagal activity.
  • An external stimulus generator may be employed with leads extending percutaneously to the implanted nerve electrode set.
  • the major problem here is the potential for infection, but it is useful to allow short term testing of the patient to determine whether the disorder suf ered by the patient under observation is amenable to successful treat ⁇ ment. If it is, a more permanent implant may be provided.

Abstract

Method and apparatus for treating and controlling respiratory disorders by detecting the presence of the respiratory disorder under treatment, and, in response, selectively applying a predetermined electrical signal to the patient's vagus nerve for modulation of its electrical activity by inhibition thereof if the respiratory disorder is asthma or cystic fibrosis, or by stimulation of the vagus nerve if the respiratory disorder is apnea.

Description

TREATMENT OF RESPIRATORY DISORDERS BY NERVE STIMULATION
Background of the Invention
The present invention relates generally to methods and apparatus for treating or controlling medical, psychiat- ric or neurological disorders by application of modulating electrical signals to a selected nerve or nerves of the pa¬ tient, and more particularly to techniques for treating patients with respiratory disorders by application of such signals to a cranial nerve, using an implantable neurostimul- ating device. Specifically, the invention is directed toward treating various respiratory disorders, such as asthma, apnea, and cystic fibrosis by selective modulation of vagus nerve electrical activity.
As a disease entity, asthma is usually idiopathic - - with attacks commonly precipitated by allergic reactions. The attacks are characterized by continuous or paroxysmal labored breathing accompanied by wheezing and a sense of constriction in the chest, and often by coughing or gasping. Apnea is a transient cessation of respiration. Sleep apneas are characterized by brief episodes of respiratory arrest, which may occur many times during sleep and may be associated with obstruction of the upper airways, cessation of diaphrag¬ matic movements and snoring. Cystic fibrosis (CF) is a hereditary disease characterized in part by abnormal secre- tion in the lungs, leading to difficulty in breathing.
Certain of the respiratory disorders are commonly treated using various drugs and medications. For example, asthma is treated with theopholine, bronchosol, and/or ste¬ roids. In the case of apnea, stimulants such as amphetamines are usually adminstered. In contrast, there is presently no significant pharmaceutical treatment of CF; although infec¬ tions such as pneumonia which are common with CF are treated with antibiotics, and such treatment may be used prophylacti- cally. However, these forms of treatment have not been very effective in all cases, and may cause undesirable side- effects. It is a principal object of the present invention to apply techniques of selective modulation of the electrical activity of a cranial nerve, and particularly the vagus nerve, to treat and control various respiratory disorders, including asthma, apnea, and cystic fibrosis.
The nerves in the human body are generally composed of thousands of fibers of different sizes designated groups A, B and C, which carry signals to and from the brain and other parts of the body. The vagus nerve, for example, may have approximately 100,000 fibers (axons) of the three different types, each of which carries such signals. Each axon of that nerve only conducts in one direction, in normal circumstances. The A and B fibers are myelinated (i.e., each has a myelin sheath composed largely of fat) , whereas the C fibers are unmyelinated. Typically, myelinated fibers are larger, conduct electrical signals faster, and are electri¬ cally stimulated at much lower thresholds than unmyelinated fibers. Such fibers exhibit a particular strength-duration curve in response to a specific width and amplitude of stimulation pulse.
The A and B fibers are stimulated with relatively narrow pulse widths, from 50 to 200 microseconds (μs) , for example. A fibers exhibit slightly faster electrical conduc¬ tivities than the B fibers, and slightly lower electrical stimulation thresholds. The C fibers are relatively much smaller, conduct electrical signals very slowly, and have high stimulation thresholds typically requiring wider pulse widths (e.g., 300-1000 μs) and higher amplitudes for activa¬ tion. Although the A and B fibers may be selectively stimulated without also stimulating the C fibers, the magnitude and width of the pulse required for stimulating the C fibers would also activate A and B fibers.
Electrical stimulation of the nerve fiber typically activates neural signals in both directions (bidirection- ally) , but selective unidirectional stimulation is achievable through the use of special nerve electrodes and stimulating waveforms. In a paper on the effects of vagal stimulation on experimentally induced seizures in rats (Epilepsia (1990) 31 (Supp 2) : S7-S19) , Woodbury has noted that the vagus nerve is composed of somatic and visceral afferents (i.e., inward conducting nerve fibers which convey impulses toward a nerve center such as the brain or spinal cord) and efferents (i.e., outward conducting nerve fibers which convey impulses to an effector to stimulate it and produce activity) . The vast majority of vagal nerve fibers are C fibers, and a majority are visceral afferents having cell bodies lying in masses or ganglia in the neck. The central projections terminate largely in the nucleus of the solitary tract which sends fibers to various regions of the brain (e.g, the hypothala- mus, thalamus, and amygdala) ; others continue to the medial reticular formation of the medulla, the cerebellum, the nucleus cuneatus and other regions.
Woodbury further notes that stimulation of vagal nerve afferent fibers in animals evokes detectable changes of the EEG in all of these regions, and that the nature and extent of these EEG changes depends on the stimulation parameters. Chase, in Exp Neurol (1966) 16:36-49, had also observed that vagal activation can affect the EEG activity of certain parts of the brain. Woodbury also observes that vagal stimulation can produce widespread inhibitory effects on seizures and certain involuntary movements.
Extra-physiologic electrical stimulation of the vagus nerve has previously been proposed for treatment of epilepsy and various forms of involuntary movement disorders. Specifically, in U.S. Patent 4,702,254 to J. Zabara (referred to herein as "the '254 patent"), a method and implantable device are disclosed for alleviating or preventing epileptic seizures, characterized by abnormal neural discharge patterns of the brain. The *254 patent describes an implantable neurocybernetic prosthesis (NCP) which utilizes neurocyb- emetic spectral discrimination by tuning the external current of the NCP generator to the electrochemical proper¬ ties of a specific group of inhibitory nerves that affect the reticular system of the brain. These nerves are embedded within a bundle of other nerves, and are selectively activat¬ ed directly or indirectly by the tuning of the NCP to augment states of brain neural discharge to control convulsions or seizures. According to the patent, the spectral discrimina¬ tion analysis dictates that certain electrical parameters of the NCP pulse generator be selected based on the electrochem¬ ical properties of the nerves desired to be activated. The patent further indicates that the optimum sites for applica- tion of the NCP generator output to produce the desired effects are the cranial nerves in general, and the vagus nerve in particular.
The NCP disclosed in the '254 patent may be activated manually or automatically to provide treatment for the duration of the seizure. Manual activation is performed when the patient experiences the aura at onset of the seizure. Alternatively, automatic activation may be trig¬ gered upon detection of instantaneous changes in certain state parameters immediately preceding or at onset of a seizure. Additionally, a prophylactic or preventive mode may be employed in which the NCP is activated periodically to reduce the occurrence and/or the intensity of the seizures. The NCP stimulator of the *254 patent is implanted in the patient's chest and is connected to electrodes installed at the selected point of signal application at the nerve site with the more negative electrode situated closer to the brain and the positive electrode further from the brain, along the vagus nerve.
One of the functions of the vagus nerve is to monitor and modulate the diameter of the bronchi. Morrison et al. reported, in Br. J. Pharmacol. (1989) 28:545-549, that patients with asthma have increased vagal activity, leading to increased bronchomotor tone, especially at night; and that increased vagal activity, rather than increased receptor sensitivity, was believed to be the cause for this phenome¬ non. Apnea may be induced by any of a variety of known causes, including degenerative diseases of the brain, and brain tumors; or may be idiopathic in origin. The condition is thought to be related to sleep disorders that vary in severity from adult snoring to sudden infant death syndrome. Abnormal control of respiration may lead to apnea. During the waking state, however, the brain stem centers responsible for respiration can be overridden by normal conscious control to initiate breathing. Hence, except for individuals with respiratory failure or serious respiratory control abnormali¬ ty, only sleep apnea is a problem. A patient suffering from Ondines Curse may completely stop breathing upon falling asleep; but even in sleep apnea condition, the patient is likely to awaken momentarily to breathe, which allows survival, albeit sleep may be fitful.
In J. APPI. Phvsiol. (1989) 67(6) :2249-2256, Holmes et al. found that stimulation of vagal C fibers in cats increases the rate and decreases the depth of respiration (shallow tachypnea) , and modulates neuronal discharges to two other muscles (the posterior crycoarytenoid and thyroaryte- noid) involved in respiration.
CF is characterized by an excessive quantity of abnormally viscous secretions. These secretions occlude the bronchi, leading to respiratory distress and pneumonia. Since vagal activity is involved in control of bronchial tone, modulation of vagal activity may be useful in increas¬ ing bronchial diameter, making it easier to clear secretions.
Summary of the Invention
The invention resides in methods and apparatus for treating respiratory disorders such as asthma, apnea and cystic fibrosis by vagal modulation. The apparatus comprises a neurostimulator for generating electrical pulses in a programmable pattern to produce the desired modulation of vagal electrical activity. According to one aspect of the invention, asthma is treated by inhibiting vagal activity to increase bronchial diameter. Apnea can be treated by stimulating the vagus nerve, to increase the respiratory rate. In the case of apnea, it is desirable that the neuro- stimulator which modulates the electrical activity of the vagus nerve be activated by a sensor adapted to detect cessation of breathing. In contrast, patient activation of the neurostimulator is preferable for asthma sufferers, because the patient can readily detect an attack and act accordingly.
As noted above, CF involves abnormal secretions in the lungs. The therapeutic modality employed for this disor¬ der, according to the invention, is to inhibit the vagus nerve to increase bronchial diameter. For this condition, the neurostimulator would operate on a continuous cycle in such a manner as to maintain maximum bronchial diameter or to alternately lead to normal and increased diameter. The latter mode would allow for clearing of accumulated secre¬ tions. Activation by the patient may also be desirable to treat acute episodes of respiratory distress.
It is postulated that inhibition of vagal activity can alleviate asthma, irrespective of whether the increased bronchomotor tone results from increased vagal activity or increased receptor sensitivity. Although vagal stimulation is usually associated with activation, parameters can likely be found for effective blocking of efferent activity. Because the vagus nerve provides feedback to the brain which results in modulation of respiration, it is further postulated that stimulation of the vagus nerve can beneficially treat or control apnea. In copending U.S. patent application Serial No. 07/695,558, the applicants have disclosed techniques for treating and controlling sleep apneas by vagal stimulation. The aspect of the present invention involving apneas is closely related to the latter, but is intended for control of apnea occurring when the patient is fully awake but incapable of exercising conscious control because of respiratory abnormality or failure.
The apparatus of the invention includes a neuro¬ stimulator (preferably but not necessarily implantable) to selectively apply the desired therapy to treat the respirato¬ ry disorder of interest by modulating the electrical activity of the patient's vagus nerve in a predetermined manner. The neurostimulator is programmed by the attending physician to provide the desired therapeutic modality for that purpose. Selection among various strategies for vagal modulation to treat the respiratory disorder of interest depends on a number of factors. These include (i) a consid¬ eration of which of the nerve fibers are to be subjected to stimulation; (ii) whether synchronization or desynchroniz- ation of the EEG may be desirable, and in either case, the modality for achieving it; (iii) whether some type of physio¬ logic signal is generated which can be detected and employed to trigger the modulation; and/or (iv) whether a "carryover" or refractory period occurs after modulation in which the benefit of the modulation is maintained. Although these are not all of the factors to be considered for selecting a stimulation strategy for treatment of the disorder, nor necessarily listed in order of importance, they are indica- tive of considerations which may apply in a specific case.
In the treatment according to the invention, different signal parameters and threshold curves are used to activate the various fibers of the patient's vagus nerve for selective modulation of the electrical activity thereof. By appropriately setting pulse width and amplitude of the electrical signal to be delivered by the neurostimulator to the patient's vagus nerve, the nerve fibers can be selec¬ tively stimulated, such as A and not B and C; or A and B, but not C; or A, B and C. Various related factors, however, must be considered in the selection process. For example, because the C fibers conduct signals very slowly, they are not highly responsive to techniques of fast stimulation. Therefore, if it were desired to increase desynchronous activity of the EEG by Stimulation of the C fibers at 50 Hz, for example, in a particular patient, it would be prudent to use a short pulse train for the stimulus. This is because the fibers would become refractory to the stimulation within a relatively short time interval and thus incapable of tracking the pattern of a longer train. After a suitable recovery period, another short pulse train may be applied to achieve further treatment. The precise pattern to be used, e.g., the length of the time intervals on and off, will depend upon and be adjusted to the individual patient and the particular respiratory disorder being treated.
Proper designation of amplitude and frequency range of the applied signals allows tuning of the fibers for EEG synchronization or desynchronization, for control of the disorder. Desynchronization of the EEG has been found to be achieved by stimulation of the vagus nerve at frequencies in the range from 20 to 75 Hz at levels above 0.1 volt, but requires signals greater than 3 volts at frequencies above 75 Hz. If the frequency is above 75 Hz and the signal is below 3 volts, EEG synchronization is achieved. The actual voltage required depends on the type and geometry of the electrode and the impedance of the electrode-tissue interface.
According to the invention, the basic stimulation strategy to control asthma or to treat CF is to decrease the electrical activity of the vagus nerve and thereby decrease bronchomotor tone. This involves inhibiting vagal activity and is triggered by manual activation by the patient upon recognizing onset or continuation of the disorder (such as severe difficulty in breathing, along with wheezing, gasping or coughing in the case of asthma) . Stimulation (inhibition) may be delivered continuously or intermittently on a prede¬ termined (preprogrammed) schedule so as to keep the bronchi dilated or to intermittently dilate them. For apnea, vagal activity is stimulated to produce an immediate increase in the respiratory rate upon detection of cessation of respira¬ tory muscle (chest) movement or of air flow through the nostril(s) .
A stimulation strategy which does not require specific detection involves the use of circadian or other rhythmic programming to automatically activate vagal stimula¬ tion in a manner to eliminate respiratory problems, particu- larly during the normal nighttime cycle. However, a detec¬ tion strategy may be implemented in each case appropriate to the disorder of interest selected to initiate the proper stimulation strategy. Broadly, then, the present invention is directed to apparatus and methods which employ a neurostimulator device, preferably implantable, for therapy or treatment of respira¬ tory disorders through nerve stimulation. The modulating signals applied to the vagus nerve may stimulate or inhibit neural signals to produce excitatory or inhibitory neuro- transmitter release, but for purposes of this disclosure both situations are included within the term "stimulating". It should be emphasized that although the preferred nerve site for application of the modulating signals is the vagus nerve, effective treatment may be achieved through application of the stimulus to one or more other nerves, particularly among the cranial nerves, and such treatment is deemed to be within the ambit of the present invention.
Accordingly, it is another object of the present invention to apply the techniques of selective modulation of vagus nerve electrical activity, using a neurostimulator device which may be implantable, or disposed external to the body with only a small portion of the circuitry implanted or with only the nerve electrode(s) and associated lead(s) implanted percutaneously in the body, to the treatment or control of respiratory disorders.
A more specific object of the invention is to provide methods and apparatus responsive to detected symptoms characteristic of or associated with certain respiratory disorders for applying preprogrammed electrical stimuli to a cranial nerve and particularly the vagus nerve of the patient to modulate the electrical activity of selected nerve fibers as part of a therapy designed to treat or control the disorder. Another object of the invention is to provide methods of treating and controlling a respiratory disorder by sensing a symptom of the disorder and automatically or manually responding thereto by modulating electrical activity of the patient's vagus nerve.
Brief Description of the Drawings
The above and still further objects, aspects, features and attendant advantages of the present invention will be better understood from a consideration of the ensuing detailed description of a presently preferred embodiment and method thereof, taken in conjunction with the accompanying drawings, in which: FIG. 1 is a simplified block diagram of an implant¬ able neurostimulator (stimulus generator) for use (with appropriate parameter settings and ranges) in treating respiratory disorders according to the present invention;
FIG. 2 is a simplified fragmentary illustration of a preferred embodiment and location of the generator and lead/electrode system of the neurostimulator implanted in the patient's body, and also illustrating the type and placement of suitable sensing devices associated with the neurostimu¬ lator for detecting respiratory disorder attacks; FIG. 3 is a detailed fragmentary illustration of the nerve electrode as implanted on the vagal nerve in the neck of the patient for modulating vagal activity; and
FIG. 4 is an illustrative idealized electrical output signal waveform of the stimulus generator useful for clarifying relevant parameters of the signal developed by the stimulus generator for application to the nerve.
Description of the Presently Preferred Embodiments and Methods
Referring now to the drawings, a block diagram of the basic components of the stimulus generator of a neurosti¬ mulator and their interrelationship is illustrated in FIG. 1, and further details of location of.an implantable version of the device and the associated lead/electrode system are shown in FIGS. 2 and 3. A generally suitable form of neurostimu- lator for use in the apparatus of the present invention is disclosed in copending U.S. patent application Ser. No. 07/434,985, filed November 10, 1989 in the names of Anthony J. Varrichio, et al. (referred to herein as "the '985 application") , assigned to the same assignee as the instant application. The specification of the '895 application is incorporated herein in its entirety by reference, but certain portions of it are summarized in this application for the sake of convenience to the reader. The neurostimulator utilizes a conventional microprocessor and other standard electrical and electronic components, and in the case of an implanted device, communi¬ cates with a programmer and/or monitor located external to the patient's body by asynchronous serial communication for controlling or indicating states of the device. Passwords, handshakes and parity checks are employed for data integrity. The neurostimulator also includes means for conserving energy, which is important in any battery operated device and especially so where the device is implanted for medical treatment of a disorder, and means for providing various safety functions such as preventing accidental reset of the device.
The stimulus generator 10 (FIG. 1) is preferably adapted to be implantable in the patient's body, in a pocket formed by the surgeon just below the skin in the chest as shown in FIG. 2, although a primarily external neurostimu¬ lator may alternatively be employed. The neurostimulator also includes implantable stimulating electrodes (described below) together with a lead system 22 for applying the output signal of the stimulus generator to the patient's vagus nerve. Components external to the patient's body include a programming wand for telemetry of parameter changes to the stimulus generator and monitoring signals from the generator, and a computer and associated software for adjustment of parameters and control of communication between the genera¬ tor, the programming wand and the computer. These external components of the system are not shown in the drawings. In conjunction with its microprocessor-based logic and control circuitry, the stimulus generator 10 or other implanted or external circuitry may include detection circuitry for sensing onset or ongoing presence of the respiratory disorder of interest to trigger automatic delivery of the stimulating signal, as will be discussed presently. In general, however, manual activation of the neurostimulator by the patient is the preferred detection strategy, provided that the patient is capable of recognizing and promptly reacting to the disorder. The stimulus genera¬ tor is designed, implemented and programmed to deliver a selectively patterned stimulating signal to modulate the electrical activity of the vagus nerve in a manner designed to treat and control the disorder. As shown in FIG. 1, stimulus generator 10 includes a battery (or set of batteries) 12, which may be of any reliable long-lasting type conventionally employed for powering implantable medical electronic devices (such as batteries employed in implantable cardiac pacemakers or defibrillators) . In the preferred embodiment of the stimulus generator, the battery is a single lithium thionyl chloride cell. The terminals of the cell 12 are connected to the input side of a voltage regulator 13. The regulator smoothes the battery output to produce a clean, steady output voltage, and provides enhancement thereof such as voltage multiplica¬ tion or division if necessary for a specific application.
Regulator 13 supplies power to logic and control section 15, which includes a microprocessor and controls the programmable functions of the device. Among these program- able functions are output current or voltage, output signal frequency, output signal pulse width, output signal on-time, output signal off-time, daily treatment time for continuous or periodic modulation of vagal activity, and output signal- start delay time. Such programmability allows the output signal to be Selectively crafted for application to the stimulating electrode set (FIGS. 2 and 3) to obtain the desired modulation of vagal activity for treatment and control of the specific respiratory disorder. Timing signals for the logic and control functions of the generator are provided by a crystal oscillator 16. A magnetically-actuated reed switch 14 is incorporated in the electronics package to provide the generator with the capability for patient activation thereof (by use of an external magnet, not shown, placed immediately adjacent to the package or its implant site) .
Built-in antenna 17 enables communication between the implanted stimulus generator and the external electronics (including both programming and monitoring devices) to permit the device to receive programming signals for parameter changes, and to transmit telemetry information, from and to the programming wand. Once the system is programmed, it operates continuously at the programmed settings until they are reprogrammed (by the attending physician) by means of the external computer and the programming wand.
Logic and control section 15 of the stimulus generator 10 controls an output circuit or section 19 which generates the programmed signal levels appropriate to the disorder being treated. The output section and its pro¬ grammed output signal are coupled (directly, capacitively, or inductively) to an electrical connector 20 on the housing 21 of the generator and to lead assembly 22 connected to the stimulating electrodes (FIGS. 2 and 3). A sense signal analysis circuit 23 is provided within the generator housing 21, with connections to the microprocessor in logic and control section 15 and to sensing electrodes, if used. The parameters of the stimulating signal of the implanted device may be calibrated by telemetry (via the programming wand) according to the needs of the particular patient and the results then programmed into the microprocessor for delivery of the appropriate treatment upon activation of the stimulus generator. Housing 21 in which stimulus generator 10 is encased is hermetically sealed and composed of a suitable conventional material such as titanium which is biologically compatible with the fluids and tissue of the patient's body. Further details of structure and operation of the neurostimu¬ lator, beyond those by which the device is adapted to treat the disorder described herein, are available in the '985 application, to which the reader is referred.
FIG. 2 illustrates the preferred location of implanted generator 10, in case 21 with connector 20, in the patient's chest in a cavity formed by the implanting surgeon just below the skin, much as a pacemaker pulse generator would be implanted. A stimulating nerve electrode set 25 (FIG. 3) is conductively connected to the distal end of insulated electrically conductive lead assembly 22 which is attached at its proximal end to connector 20. Electrode set 25 is a bipolar stimulating electrode, preferably of the type described in U.S. Patent 4,573,481 issued March 4, 1986 to Bullara. The electrode assembly is surgically implanted on the vagus nerve 27 in the patient's neck. The two electrodes 25-1 and 25-2 are wrapped about the vagus nerve, and the assembly is secured to the nerve by a spiral anchoring tether 28 preferably as disclosed in U.S. Patent 4,979,511 issued December 25, 1990 to Reese S. Terry, Jr. and assigned to the same assignee as the instant application. Lead(s) 22 is secured, while retaining the ability to flex with movement of the chest and neck, by a suture connection 30 to nearby tissue.
The open helical design of electrode assembly 25 (described in detail in the above-cited Bullara patent) , which is self-sizing and flexible, minimizes mechanical trauma to the nerve and allows body fluid interchange with the nerve. The electrode assembly conforms to the shape of the nerve, providing a low stimulation threshold by allowing a larger stimulation contact area. Structurally, the electrode assembly comprises two ribbons of platinum consti¬ tuting the electrodes which are individually bonded to the inside surface of each of the first two spiral loops 25-1 and 25-2 of a three-loop helical assembly, and the two lead wires are respectively welded to the conductive ribbon electrodes. The remainder of each loop is composed of silicone rubber, and the third loop acts as the tether 28 for the electrode assembly. The inner diameter of the helical bipolar elec¬ trode assembly may typically be approximately two millimeters (mm) , and an individual spiral is about seven mm long (measured along the axis of the nerve) .
Forpatients generally suffering respiratory disor¬ ders, but especially for apnea patients the cessation of respiration may be detected by an externally-positioned breathing sensor placed in the patient's nostril as shown at 50 in FIG. 2. A suitable breathing sensor merely detects the presence or absence of nasal air flow and is worn in or near one nostril. Processing of the nasal air flow signal is performed by a suitable external circuit 53 (or internal signal analysis circuit 23) which is adapted to generate an activation command to the microprocessor of logic and control circuit 15. A suitable processing/analysis circuit is an RF signal generator which is adapted to be triggered by a sus¬ tained absence of nasal air flow for a predetermined interval of time.
Alternatively, a totally implanted sensing system may be employed, if desired, for example using a device which senses movement of the patient's diaphragm associated with normal breathing. Preferably, the diaphragm movement is sensed by an impedance detector, or alternatively, by plural electrodes for detecting physical movement of the muscle, implanted in the chest of the patient as shown generally at 60 in FIG. 2. The detector generates a signal indicative of absence of diaphra movement for a time interval set accord- ing to the above-mentioned criteria, which is conveyed by implanted lead 62 to trigger application of vagal stimulation by generator 10 under the command of the microprocessor when it determines a lack of movement. Alternatively, the detector may process the signal and send a trigger signal with absence of movement.
The stimulus generator may be programmed with an IBM-compatible personal computer (not shown) using program- ming software of the type copyrighted by the assignee of the instant application with the Register of Copyrights, Library of Congress, or other suitable software based on the descrip¬ tion herein, and a programming wand (not shown) . The wand and software permit noninvasive communication with the generator after the latter is implanted. The wand is preferably powered by internal batteries, and provided with a "power on" light to indicate sufficient power for communi¬ cation. Another indicator light is preferably provided to show that data transmission is occurring between the wand and the generator.
The operation of stimulus generator 10 to control and treat respiratory disorders utilizes the signal parame¬ ters shown in FIG. 4, which is an idealized representation of the output signal waveform delivered by output section 19 of the neurostimulator to electrode assembly 25. This illustra¬ tion is presented principally to clarify terminology, including the parameters of output signal on-time, output signal off-time, output signal frequency, output signal pulse width, and output signal current or voltage.
In the treatment of asthma or CF according to the invention, the stimulation strategy is to decrease the pat¬ ient's vagal activity and thereby decrease the bronchomotor tone, especially at night. The detection strategy for automatic activation of the neurostimulator to that end is to sense either air flow or the amount of vagal activity in a manner which will be discussed in greater detail presently. Preferably, however, the patient suffering from asthma or cystic fibrosis is provided with the capability to manually activate the neurostimulator when the onset of an attack is sensed. This is readily accomplished by placing an external magnet directly over the site of the implanted stimulus generator to actuate the reed switch 14 (FIG. 1) .
A suitable range of stimulation parameters and the typical value of each parameter of the stimulating output signal for treatment of asthma or CF are set forth in Table I below: TABLE I Range Typical
Pulse Width 0.05 - 1.5 ms 0.5 ms Output Current 0.1 - 5.0 mA 1.5 mA Frequency 5 - 150 Hz 100 Hz ON Time 5 - 5000 sec 500 sec OFF Time 5 - 5000 sec 10 sec Frequency sweep 10 - 50 Hz Optional Random frequency 10 - 50 Hz Optional A technique for initiating stimulation without a detection system, either machine sensor or patient sensing, is to program the neurostimulator for activation according to the circadian rhythm of the particular patient and the disorder being treated. For example, the stimulus generator may be programmed to generate its pulses with the selected parameters at one or more set times during the night. Alternatively, automatic detection and stimulation may be employed during the patient's normal sleeping hours, and biased off during the day to require manual activation in that portion of the 24-hour cycle.
In contrast to treating asthma by inhibiting vagal activity to increase bronchial diameter such as when the patient senses an attack, apnea is treated by stimulating the vagus nerve to increase the respiratory rate upon automatic detection of sustained cessation of breathing. Air flow or chest movement sensors of the types described above with reference to FIG. 2 are preferred. The stimulation strategy involves programming the neurostimulator to desynchronize the apnea patient's EEG activity upon such detection, and thereby increase respiration. For desynchronization, the parameters of the stimulus signal may be programmed, for example, at a frequency of 20 Hz, an output current of 1.5 mA, and a pulse width of 0.5 ms for the pulse waveform. A suitable range of stimulation parameters for desynchronization of the patient's EEG activity, and the typical value of each parameter of the stimulating output signal for treatment of apnea are set forth in Table II: TABLE II Range Typical
Pulse Width 0.05 - 1.5 ms 0.5 ms Output Current 0.1 - 5.0 mA 1.5 mA Frequency 5 - 150 Hz 20 HZ ON Time 5 - 5000 sec 300 sec OFF Time 5 - 5000 sec 20 sec Frequency sweep 10 - 100 Hz Optional Random frequency 10 - 100 Hz Optional As noted earlier herein, a technique for initiating stimulation without a specific detection system is to program the neurostimulator according to the circadian rhythm of the particular apnea patient, or intermittently, to desynchronize the patient's EEG activity as appropriate. A secondary mode of stimulation for treating apnea patients, which may be employed either as an alternative or as an adjunct to the previously described operation, is to apply a painful stimulus such as a mild electric shock to the patient either at the end of the initial time interval with no breathing or after a subsequent shorter time interval indicative of no response by the patient to the normal pulse stimuli from the neurostimulator. The purpose here is to bring the patient back to consciousness and thereby restore breathing through conscious control. Various features may be incorporated into the neurostimulator for purposes of the saf ty and comfort of the patient. For example, comfort is enhanced by programming the output stimulus to ramp up during the first two seconds of stimulation, rather than to be delivered abruptly. Also, the implanted generator may be provided with a clamping circuit to limit the maximum voltage delivered to the vagus nerve (for example, to 14 volts) . The maximum limit is set to prevent injury or trauma to the patient's vagus nerve.
The programmable functions and capabilities of the neurostimulator are designed and implemented to permit noninvasive communication with the stimulus generator after it is implanted, which is useful for both activation and monitoring functions. Beyond the essential functions of the device, the programming software may readily be structured to provide straightforward menu-driven operation, HELP func¬ tions, prompts, and messages to facilitate simple and rapid programming while keeping the user fully informed of every- thing occurring at each step of a sequence. Programming capabilities should include capability to modify the adjust¬ able parameters of the stimulus generator and its output signal, to test device diagnostics, and to store and retrieve telemetered data. It is desirable that when the implanted unit is interrogated, the present state of the adjustable parameters is displayed on the monitor of external PC so that the programmer may then conveniently change any or all of those parameters at the same time; and, if a particular parameter is selected for change, all permissible values for that parameter are displayed so that the programmer (typical¬ ly, limited to the attending physician) may select an appropriate desired value for entry into the neurostimulator. Diagnostics testing should be implemented to verify proper operation of the device, and to indicate the existence of problems such as with communication, the battery, or the lead/electrode impedance. A low battery reading, for example, would be indicative of imminent end of life of the battery and need for implantation of a new device. The nerve electrodes are capable of indefinite use absent indication of a problem with them observed on the diagnostics testing.
Although a preferred embodiment and method of controlling respiratory disorders have been described herein, it will be apparent to those skilled in the field from a consideration of the foregoing description that variations and modifications may be made without departing from the spirit and scope of the invention. For example, a totally implantable neurostimulator device need not be utilized. Instead, the electronic energization package may be primarily external to the body, and stimulation achieved with an RF power device implemented to provide the necessary energy level. The implanted components may be limited to the lead/electrode assembly, a coil and a DC rectifier, and pulses programmed with the desired parameters transmitted through the skin with an RF carrier. The signal is rectified to regenerate a pulsed signal for application as the stimulus to the vagus nerve to modulate vagal activity. This virtual- ly eliminates battery changes, but has the disadvantages that the external transmitter must be carried by the patient, greater power is required for activation, and the output current to the nerve is less stable. An external stimulus generator may be employed with leads extending percutaneously to the implanted nerve electrode set. The major problem here is the potential for infection, but it is useful to allow short term testing of the patient to determine whether the disorder suf ered by the patient under observation is amenable to successful treat¬ ment. If it is, a more permanent implant may be provided.
Accordingly, it is intended that the invention shall be limited only to the extent required by the appended claims and the rules and principles of applicable law.

Claims

What is claimed is:
1. A method of treating patients with respiratory disorders, which includes detecting an event indicative of the respiratory disorder to be treated, and upon detection of said event, selectively applying a predetermined electrical signal to the patient's vagus nerve for stimulation thereof to alleviate the respiratory disorder under treatment.
2. The method of claim 1, wherein the predetermined electrical signal is programmable to modulate the electrical activity of the vagus nerve and thereby control another physiological parameter of the patient.
3. The method of claim 2, wherein the predetermined electrical signal is a pulse waveform with programmable signal parameters.
4. The method of claim 1, wherein the event is detectable by the patient, and the electrical signal is manually activatable.
5. The method of claim 3, wherein the respiratory disorder is asthma, and the pulse waveform is programmed to inhibit vagal activity to increase bronchial diameter.
6. The method of claim 3, wherein the respiratory disorder is cystic fibrosis, and the pulse waveform is programmed to inhibit vagal activity to increase bronchial diameter.
7. The method of claim 3, wherein the respiratory disorder is apnea, and the pulse waveform is programmed to stimulate vagal activity to increase the respiratory rate upon automatic detection of sustained cessation of breathing.
8. The method of claim 7, wherein the predetermined signal has electrical parameters programmed to cause desynchronization of the patient's EEG.
9. The method of claim 7, further including applying a painful stimulus to awaken the patient upon failure of initiate breathing by the patient in response to the programmed pulse waveform.
10. The method of claim 3, wherein the programmable signal parameters of the pulse waveform include at least some of pulse width, output current or voltage, frequency, on time and off time.
11. In a method of treating patients with respira¬ tory disorders, the step of applying an electrical signal with parameters programmed to alleviate the respiratory disorder under treatment to the vagus nerve of the patient to modulate the electrical activity thereof at predetermined times and for predetermined time intervals during the patient's circadian cycle.
12. A device for treating respiratory disorders in human patients, the combination comprising: stimulus means for generating a programmable electrical waveform, implantable electrode means electrically connect- able to said stimulus means for delivering said waveform to the vagus nerve of the patient, and programming means for applying said waveform to said electrode means with selected parameter values of the waveform programmed to stimulate the vagus nerve to modulate the electrical activity thereof according to the nature of the respiratory disorder under treatment.
13. The invention of claim 12, wherein said programming means includes means for selecting the parameter values of the waveform to inhibit or to stimulate the electrical activity of the patient's vagus nerve according to whether the respiratory disorder under treatment is difficulty in breathing or complete cessation of breathing, respectively.
14. The invention of claim 12, further including sensing means to detect an event indicative of onset of the respiratory disorder under treatment, for initiating the application of said waveform to said electrode means.
15. The invention of claim 12, wherein said programming means applies said waveform to said electrode means at predetermined times and for predeter¬ mined time intervals during the patient's circadian cycle.
16. The invention of claim 14, wherein said sensing means includes means for detecting a cessation of respiration of the patient.
17. The invention of claim 16, wherein said means for detecting cessation of respiration includes means responsive to the absence of movement of the patient's diaphragm.
18. The invention of claim 16, wherein said means for detecting cessation of respiration includes means responsive to the absence of nasal air flow by the patient.
19. The invention of claim 16, wherein the parameter values of the waveform are selected by said programming means to stimulate vagal activity and thereby increase the patient's respiration rate.
20. The invention of claim 19, wherein the stimulation of vagal activity desynchronizes the patient's EEG.
PCT/US1992/005980 1991-07-22 1992-07-22 Treatment of respiratory disorders by nerve stimulation WO1993001862A1 (en)

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EP0702978A2 (en) * 1994-09-21 1996-03-27 Medtronic, Inc. Apparatus for treating obstructive sleep apnea
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WO1997013551A1 (en) * 1995-10-11 1997-04-17 Trustees Of Boston University Method and apparatus for improving the function of sensory cells
WO2000000245A1 (en) * 1998-06-30 2000-01-06 Siemens-Elema Ab Respiratory aid system with respiration detector, picking up neuroelectrical signals
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Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2664880A (en) * 1951-11-23 1954-01-05 Jr Nathaniel B Wales Electric stimulator for artificial respiration
DE2129953A1 (en) * 1970-07-24 1972-12-21 Siemens Ag Rheograph
US3782386A (en) * 1972-05-08 1974-01-01 Dynatech Corp Cryosurgical apparatus
US3802417A (en) * 1968-12-21 1974-04-09 V Lang Device for combined monitoring and stimulation of respiration
DE2437346A1 (en) * 1973-08-10 1975-02-20 Herwig Dipl Ing Dr Thoma Nerve and muscle stimulator - gives stimulus currents varied with location and time from switching logic and relay chain
US4063550A (en) * 1976-05-28 1977-12-20 Tiep Brian L Method and apparatus for treating bronchial asthma
SU733679A1 (en) * 1977-11-10 1980-05-15 Всесоюзный Научно-Исследовательский Институт Медицинского Приборостроения Respiration stimulator
SU955938A1 (en) * 1981-03-04 1982-09-07 Центральный Ордена Трудового Красного Знамени Научно-Исследовательский Институт Курортологии И Физиотерапии Method of treating bronchial asthma
GB2103807A (en) * 1981-08-06 1983-02-23 Gaspar Formenbau Ag Apparatus for stopping a sleeping person from snoring
US4420001A (en) * 1979-01-19 1983-12-13 Hearne Keith M T Respiratory measuring devices
SU1113120A1 (en) * 1982-06-11 1984-09-15 Белорусский государственный институт усовершенствования врачей Method of treatment of atopic bronchial asthma
US4506666A (en) * 1982-12-03 1985-03-26 Kircaldie, Randall And Mcnab Method and apparatus for rectifying obstructive apnea
SU1194416A1 (en) * 1983-01-11 1985-11-30 Portnov Foma G Method of treatment of bronchial asthma
US4715367A (en) * 1986-09-15 1987-12-29 Crossley Robert B Multifunctional behavioral modification device for snoring, bruxism, and apnea
EP0293068A1 (en) * 1987-05-27 1988-11-30 Teijin Limited An electric therapeutic apparatus
US4830008A (en) * 1987-04-24 1989-05-16 Meer Jeffrey A Method and system for treatment of sleep apnea
EP0344920A1 (en) * 1988-05-04 1989-12-06 Michael James Williams Brennan Treatment of sleep disorders and alleviating disruption of circadian rhythms
US5025807A (en) * 1983-09-14 1991-06-25 Jacob Zabara Neurocybernetic prosthesis
US5036848A (en) * 1989-10-16 1991-08-06 Brunswick Biomedical Technologies, Inc. Method and apparatus for controlling breathing employing internal and external electrodes
WO1991017706A1 (en) * 1990-05-18 1991-11-28 Cns, Inc. Obstructive sleep apnea monitoring

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5335657A (en) * 1991-05-03 1994-08-09 Cyberonics, Inc. Therapeutic treatment of sleep disorder by nerve stimulation

Patent Citations (20)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US2664880A (en) * 1951-11-23 1954-01-05 Jr Nathaniel B Wales Electric stimulator for artificial respiration
US3802417A (en) * 1968-12-21 1974-04-09 V Lang Device for combined monitoring and stimulation of respiration
DE2129953A1 (en) * 1970-07-24 1972-12-21 Siemens Ag Rheograph
US3782386A (en) * 1972-05-08 1974-01-01 Dynatech Corp Cryosurgical apparatus
DE2437346A1 (en) * 1973-08-10 1975-02-20 Herwig Dipl Ing Dr Thoma Nerve and muscle stimulator - gives stimulus currents varied with location and time from switching logic and relay chain
US4063550A (en) * 1976-05-28 1977-12-20 Tiep Brian L Method and apparatus for treating bronchial asthma
SU733679A1 (en) * 1977-11-10 1980-05-15 Всесоюзный Научно-Исследовательский Институт Медицинского Приборостроения Respiration stimulator
US4420001A (en) * 1979-01-19 1983-12-13 Hearne Keith M T Respiratory measuring devices
SU955938A1 (en) * 1981-03-04 1982-09-07 Центральный Ордена Трудового Красного Знамени Научно-Исследовательский Институт Курортологии И Физиотерапии Method of treating bronchial asthma
GB2103807A (en) * 1981-08-06 1983-02-23 Gaspar Formenbau Ag Apparatus for stopping a sleeping person from snoring
SU1113120A1 (en) * 1982-06-11 1984-09-15 Белорусский государственный институт усовершенствования врачей Method of treatment of atopic bronchial asthma
US4506666A (en) * 1982-12-03 1985-03-26 Kircaldie, Randall And Mcnab Method and apparatus for rectifying obstructive apnea
SU1194416A1 (en) * 1983-01-11 1985-11-30 Portnov Foma G Method of treatment of bronchial asthma
US5025807A (en) * 1983-09-14 1991-06-25 Jacob Zabara Neurocybernetic prosthesis
US4715367A (en) * 1986-09-15 1987-12-29 Crossley Robert B Multifunctional behavioral modification device for snoring, bruxism, and apnea
US4830008A (en) * 1987-04-24 1989-05-16 Meer Jeffrey A Method and system for treatment of sleep apnea
EP0293068A1 (en) * 1987-05-27 1988-11-30 Teijin Limited An electric therapeutic apparatus
EP0344920A1 (en) * 1988-05-04 1989-12-06 Michael James Williams Brennan Treatment of sleep disorders and alleviating disruption of circadian rhythms
US5036848A (en) * 1989-10-16 1991-08-06 Brunswick Biomedical Technologies, Inc. Method and apparatus for controlling breathing employing internal and external electrodes
WO1991017706A1 (en) * 1990-05-18 1991-11-28 Cns, Inc. Obstructive sleep apnea monitoring

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
Journal of Thoracic and Cardio Vascular Surgery, Volume 5f, November 1, July 1968, BILGUTAY, A.M. et al., "Vagal Tuning", pp. 71-82 (see page 73). *
See also references of EP0600916A4 *

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EP0702979A2 (en) * 1994-09-21 1996-03-27 Medtronic, Inc. Apparatus for detecting and treating obstructive airway disorders
EP0702977A2 (en) * 1994-09-21 1996-03-27 Medtronic, Inc. Apparatus for detecting and treating obstructive airway disorders
JPH08224317A (en) * 1994-09-21 1996-09-03 Medtronic Inc Apparatus for medical treatment for therapy of obstructive sleep and apnea patient and apparatus for medical treatment for detecting emergence from sleep
EP0702977A3 (en) * 1994-09-21 1997-03-19 Medtronic Inc Apparatus for detecting and treating obstructive airway disorders
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EP0702978A2 (en) * 1994-09-21 1996-03-27 Medtronic, Inc. Apparatus for treating obstructive sleep apnea
US6032074A (en) * 1995-10-11 2000-02-29 Trustees Of Boston University Method and apparatus for improving the function of sensory cells
US5782873A (en) * 1995-10-11 1998-07-21 Trustees Of Boston University Method and apparatus for improving the function of sensory cells
WO1997013551A1 (en) * 1995-10-11 1997-04-17 Trustees Of Boston University Method and apparatus for improving the function of sensory cells
EP0940155A3 (en) * 1998-02-04 2000-05-17 Medtronic, Inc. Apparatus for management of sleep apnea
WO2000000245A1 (en) * 1998-06-30 2000-01-06 Siemens-Elema Ab Respiratory aid system with respiration detector, picking up neuroelectrical signals
WO2001074446A1 (en) 2000-03-29 2001-10-11 Patent Max Q (P.M.Q) Ltd. Implanted and programmable electrostimulator for stimulating organs and tissues of an organism
US8914114B2 (en) 2000-05-23 2014-12-16 The Feinstein Institute For Medical Research Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation
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US6512955B1 (en) 2000-08-07 2003-01-28 Mcenany Thomas J. Electrical apparatus for therapeutic treatment
US7167751B1 (en) 2001-03-01 2007-01-23 Advanced Bionics Corporation Method of using a fully implantable miniature neurostimulator for vagus nerve stimulation
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US11179560B2 (en) 2005-11-10 2021-11-23 Electrocore, Inc. Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation
US9020598B2 (en) 2005-11-10 2015-04-28 ElectroCore, LLC Methods and devices for treating primary headache
US10213601B2 (en) 2005-11-10 2019-02-26 Electrocore, Inc. Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation
US9014823B2 (en) 2005-11-10 2015-04-21 ElectroCore, LLC Methods and devices for treating primary headache
US9233246B2 (en) 2005-11-10 2016-01-12 ElectroCore, LLC Methods and devices for treating primary headache
US9233258B2 (en) 2005-11-10 2016-01-12 ElectroCore, LLC Magnetic stimulation devices and methods of therapy
EP1948301A4 (en) * 2005-11-10 2009-10-14 Electrocore Inc Electrical stimulation treatment of bronchial constriction
US8972004B2 (en) 2005-11-10 2015-03-03 ElectroCore, LLC Magnetic stimulation devices and methods of therapy
US10384061B2 (en) 2005-11-10 2019-08-20 Electrocore, Inc. Methods and devices for treating primary headache
US11654277B2 (en) 2005-11-10 2023-05-23 Electrocore, Inc. Nerve stimulation devices and methods
AU2006338184B2 (en) * 2006-02-10 2011-11-24 ElectroCore, LLC. Electrical stimulation treatment of hypotension
US9283390B2 (en) 2006-02-10 2016-03-15 ElectroCore, LLC Methods and apparatus for treating anaphylaxis using electrical modulation
US9339653B2 (en) 2006-02-10 2016-05-17 ElectroCore, LLC Electrical stimulation treatment of hypotension
US8948873B2 (en) 2006-02-10 2015-02-03 ElectroCore, LLC Electrical stimulation treatment of hypotension
WO2007092062A1 (en) * 2006-02-10 2007-08-16 Electrocore, Inc. Methods and apparatus for treating anaphylaxis using electrical modulation
US8934977B2 (en) 2006-02-10 2015-01-13 ElectroCore, LLC Methods and apparatus for treating anaphylaxis using electrical modulation
US9289599B2 (en) 2006-03-29 2016-03-22 Dignity Health Vagus nerve stimulation method
US9108041B2 (en) 2006-03-29 2015-08-18 Dignity Health Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US9533151B2 (en) 2006-03-29 2017-01-03 Dignity Health Microburst electrical stimulation of cranial nerves for the treatment of medical conditions
US8483834B2 (en) 2006-08-30 2013-07-09 Cardiac Pacemakers, Inc. Method and apparatus for controlling neural stimulation during disordered breathing
US8050765B2 (en) 2006-08-30 2011-11-01 Cardiac Pacemakers, Inc. Method and apparatus for controlling neural stimulation during disordered breathing
US9216291B2 (en) 2006-08-30 2015-12-22 Cardiac Pacemakers, Inc. Method and apparatus for controlling neural stimulation during disordered breathing
US8121692B2 (en) 2006-08-30 2012-02-21 Cardiac Pacemakers, Inc. Method and apparatus for neural stimulation with respiratory feedback
US8554323B2 (en) 2006-08-30 2013-10-08 Cardiac Pacemakers, Inc. Method and apparatus for neural stimulation with respiratory feedback
US8923971B2 (en) 2006-08-30 2014-12-30 Cardiac Pacemakers, Inc. Method and apparatus for neural stimulation with respiratory feedback
US8989862B2 (en) 2007-05-30 2015-03-24 The Cleveland Clinic Foundation Apparatus and method for treating pulmonary conditions
US8983609B2 (en) 2007-05-30 2015-03-17 The Cleveland Clinic Foundation Apparatus and method for treating pulmonary conditions
US8391970B2 (en) 2007-08-27 2013-03-05 The Feinstein Institute For Medical Research Devices and methods for inhibiting granulocyte activation by neural stimulation
US8155744B2 (en) 2007-12-13 2012-04-10 The Cleveland Clinic Foundation Neuromodulatory methods for treating pulmonary disorders
US8229564B2 (en) 2007-12-13 2012-07-24 The Cleveland Clinic Foundation Neuromodulatory methods for treating pulmonary disorders
US9125643B2 (en) 2008-02-15 2015-09-08 Holaira, Inc. System and method for bronchial dilation
US11058879B2 (en) 2008-02-15 2021-07-13 Nuvaira, Inc. System and method for bronchial dilation
US9211409B2 (en) 2008-03-31 2015-12-15 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation of T-cell activity
US9662490B2 (en) 2008-03-31 2017-05-30 The Feinstein Institute For Medical Research Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug
US10149714B2 (en) 2008-05-09 2018-12-11 Nuvaira, Inc. Systems, assemblies, and methods for treating a bronchial tree
US9668809B2 (en) 2008-05-09 2017-06-06 Holaira, Inc. Systems, assemblies, and methods for treating a bronchial tree
US8961507B2 (en) 2008-05-09 2015-02-24 Holaira, Inc. Systems, assemblies, and methods for treating a bronchial tree
US8961508B2 (en) 2008-05-09 2015-02-24 Holaira, Inc. Systems, assemblies, and methods for treating a bronchial tree
US8412338B2 (en) 2008-11-18 2013-04-02 Setpoint Medical Corporation Devices and methods for optimizing electrode placement for anti-inflamatory stimulation
US10335593B2 (en) 2009-03-20 2019-07-02 Electrocore, Inc. Devices and methods for monitoring non-invasive vagus nerve stimulation
US8918178B2 (en) 2009-03-20 2014-12-23 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US11389103B2 (en) 2009-03-20 2022-07-19 Electrocore, Inc Devices and methods for monitoring non-invasive vagus nerve stimulation
US10232178B2 (en) 2009-03-20 2019-03-19 Electrocore, Inc. Non-invasive magnetic or electrical nerve stimulation to treat or prevent dementia
US8983629B2 (en) 2009-03-20 2015-03-17 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US9254383B2 (en) 2009-03-20 2016-02-09 ElectroCore, LLC Devices and methods for monitoring non-invasive vagus nerve stimulation
US9248286B2 (en) 2009-03-20 2016-02-02 ElectroCore, LLC Medical self-treatment using non-invasive vagus nerve stimulation
US10220207B2 (en) 2009-03-20 2019-03-05 Electrocore, Inc. Nerve stimulation methods for averting imminent onset or episode of a disease
US11534600B2 (en) 2009-03-20 2022-12-27 Electrocore, Inc. Non-invasive nerve stimulation to treat or prevent autism spectrum disorders and other disorders of psychological development
US10376696B2 (en) 2009-03-20 2019-08-13 Electrocore, Inc. Medical self-treatment using non-invasive vagus nerve stimulation
US9403001B2 (en) 2009-03-20 2016-08-02 ElectroCore, LLC Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders
US9415219B2 (en) 2009-03-20 2016-08-16 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US10207106B2 (en) 2009-03-20 2019-02-19 ElectroCore, LLC Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders
US8983628B2 (en) 2009-03-20 2015-03-17 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US10507325B2 (en) 2009-03-20 2019-12-17 Electrocore, Inc. Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
US10512769B2 (en) 2009-03-20 2019-12-24 Electrocore, Inc. Non-invasive magnetic or electrical nerve stimulation to treat or prevent autism spectrum disorders and other disorders of psychological development
US9126050B2 (en) 2009-03-20 2015-09-08 ElectroCore, LLC Non-invasive vagus nerve stimulation devices and methods to treat or avert atrial fibrillation
US9623240B2 (en) 2009-03-20 2017-04-18 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US8676330B2 (en) 2009-03-20 2014-03-18 ElectroCore, LLC Electrical and magnetic stimulators used to treat migraine/sinus headache and comorbid disorders
US11298535B2 (en) 2009-03-20 2022-04-12 Electrocore, Inc Non-invasive vagus nerve stimulation
US10286212B2 (en) 2009-03-20 2019-05-14 Electrocore, Inc. Nerve stimulation methods for averting imminent onset or episode of a disease
US10232174B2 (en) 2009-03-20 2019-03-19 Electrocore, Inc. Non-invasive electrical and magnetic nerve stimulators used to treat overactive bladder and urinary incontinence
US11701515B2 (en) 2009-03-20 2023-07-18 Electrocore, Inc Non-invasive nerve stimulation with mobile device
US10252074B2 (en) 2009-03-20 2019-04-09 ElectroCore, LLC Nerve stimulation methods for averting imminent onset or episode of a disease
US10265523B2 (en) 2009-03-20 2019-04-23 Electrocore, Inc. Non-invasive treatment of neurodegenerative diseases
US11197998B2 (en) 2009-03-20 2021-12-14 Electrocore, Inc. Medical self-treatment using non-invasive vagus nerve stimulation
US9849286B2 (en) 2009-05-01 2017-12-26 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US9211410B2 (en) 2009-05-01 2015-12-15 Setpoint Medical Corporation Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US9700716B2 (en) 2009-06-09 2017-07-11 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
US10716936B2 (en) 2009-06-09 2020-07-21 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
US8886339B2 (en) 2009-06-09 2014-11-11 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
US9174041B2 (en) 2009-06-09 2015-11-03 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
US10220203B2 (en) 2009-06-09 2019-03-05 Setpoint Medical Corporation Nerve cuff with pocket for leadless stimulator
US8224449B2 (en) 2009-06-29 2012-07-17 Boston Scientific Neuromodulation Corporation Microstimulator with flap electrodes
US9649153B2 (en) 2009-10-27 2017-05-16 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
US9005195B2 (en) 2009-10-27 2015-04-14 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
US9017324B2 (en) 2009-10-27 2015-04-28 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
US8932289B2 (en) 2009-10-27 2015-01-13 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
US9675412B2 (en) 2009-10-27 2017-06-13 Holaira, Inc. Delivery devices with coolable energy emitting assemblies
US8996116B2 (en) 2009-10-30 2015-03-31 Setpoint Medical Corporation Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction
US11712283B2 (en) 2009-11-11 2023-08-01 Nuvaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
US10610283B2 (en) 2009-11-11 2020-04-07 Nuvaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
US11389233B2 (en) 2009-11-11 2022-07-19 Nuvaira, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
US9649154B2 (en) 2009-11-11 2017-05-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
US9149328B2 (en) 2009-11-11 2015-10-06 Holaira, Inc. Systems, apparatuses, and methods for treating tissue and controlling stenosis
US11051744B2 (en) 2009-11-17 2021-07-06 Setpoint Medical Corporation Closed-loop vagus nerve stimulation
US11110287B2 (en) 2009-12-23 2021-09-07 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US9162064B2 (en) 2009-12-23 2015-10-20 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US8612002B2 (en) 2009-12-23 2013-12-17 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US8855767B2 (en) 2009-12-23 2014-10-07 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US9993651B2 (en) 2009-12-23 2018-06-12 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US10384068B2 (en) 2009-12-23 2019-08-20 Setpoint Medical Corporation Neural stimulation devices and systems for treatment of chronic inflammation
US10016615B2 (en) 2010-08-19 2018-07-10 ElectroCore, LLC Non-invasive treatment of bronchial constriction
US11623078B2 (en) 2010-08-19 2023-04-11 Electrocore, Inc Devices and methods for non-invasive vagal nerve stimulation
US11123545B2 (en) 2010-08-19 2021-09-21 Electrocore, Inc. Devices and methods for nerve stimulation
US10363415B2 (en) 2010-08-19 2019-07-30 Electrocore, Inc. Devices and methods for non-invasive electrical stimulation and their use for Vagal nerve stimulation
US11779756B2 (en) 2010-08-19 2023-10-10 Electrocore, Inc. Systems and methods for vagal nerve stimulation
US9555260B2 (en) 2010-08-19 2017-01-31 ElectroCore, LLC Non-invasive treatment of bronchial constriction
US11147961B2 (en) 2010-08-19 2021-10-19 Electrocore, Inc. Devices and methods for nerve stimulation
US11389646B2 (en) 2010-08-19 2022-07-19 Electrocore, Inc Systems and methods for treating headache with vagal nerve stimulation
US9327118B2 (en) 2010-08-19 2016-05-03 ElectroCore, LLC Non-invasive treatment of bronchial constriction
US11141582B2 (en) 2010-08-19 2021-10-12 Electrocore, Inc Devices and methods for nerve stimulation
US11191953B2 (en) 2010-08-19 2021-12-07 Electrocore, Inc. Systems and methods for vagal nerve stimulation
US11324943B2 (en) 2010-08-19 2022-05-10 Electrocore, Inc Devices and methods for vagal nerve stimulation
US11400288B2 (en) 2010-08-19 2022-08-02 Electrocore, Inc Devices and methods for electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
US10639490B2 (en) 2010-08-19 2020-05-05 Electrocore, Inc. Non-invasive treatment of bronchial construction
US11458325B2 (en) 2010-08-19 2022-10-04 Electrocore, Inc Non-invasive nerve stimulation to patients
US9333347B2 (en) 2010-08-19 2016-05-10 ElectroCore, LLC Devices and methods for non-invasive electrical stimulation and their use for vagal nerve stimulation on the neck of a patient
WO2012046074A1 (en) 2010-10-06 2012-04-12 Isis Innovation Ltd Method and apparatus for treating respiratory disease
US11432760B2 (en) 2011-01-12 2022-09-06 Electrocore, Inc. Devices and methods for remote therapy and patient monitoring
US11850056B2 (en) 2011-01-12 2023-12-26 Electrocore, Inc. Devices and methods for remote therapy and patient monitoring
US9717904B2 (en) 2011-03-10 2017-08-01 ElectroCore, LLC Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
US10384059B2 (en) 2011-03-10 2019-08-20 Electrocore, Inc. Non-invasive vagal nerve stimulation to treat disorders
US10173048B2 (en) 2011-03-10 2019-01-08 Electrocore, Inc. Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
US11439818B2 (en) 2011-03-10 2022-09-13 Electrocore, Inc. Electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders
US11458297B2 (en) 2011-03-10 2022-10-04 Electrocore, Inc Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
US9067054B2 (en) 2011-03-10 2015-06-30 ElectroCore, LLC Devices and methods for non-invasive capacitive electrical stimulation and their use for vagus nerve stimulation on the neck of a patient
US9358381B2 (en) 2011-03-10 2016-06-07 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US9399134B2 (en) 2011-03-10 2016-07-26 ElectroCore, LLC Non-invasive vagal nerve stimulation to treat disorders
US11511109B2 (en) 2011-03-10 2022-11-29 Electrocore, Inc. Non-invasive magnetic or electrical nerve stimulation to treat gastroparesis, functional dyspepsia, and other functional gastrointestinal disorders
US10279163B2 (en) 2011-03-10 2019-05-07 Electrocore, Inc. Electrical and magnetic stimulators used to treat migraine/sinus headache, rhinitis, sinusitis, rhinosinusitis, and comorbid disorders
US11517742B2 (en) 2011-03-10 2022-12-06 Electrocore, Inc Non-invasive vagal nerve stimulation to treat disorders
US8788034B2 (en) 2011-05-09 2014-07-22 Setpoint Medical Corporation Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation
US9566426B2 (en) 2011-08-31 2017-02-14 ElectroCore, LLC Systems and methods for vagal nerve stimulation
US10286211B2 (en) 2011-08-31 2019-05-14 Electrocore, Inc. Systems and methods for vagal nerve stimulation
US9833621B2 (en) 2011-09-23 2017-12-05 Setpoint Medical Corporation Modulation of sirtuins by vagus nerve stimulation
US9028391B2 (en) 2011-12-15 2015-05-12 The Board Of Trustees Of The Leland Stanford Jr. University Apparatus and methods for treating pulmonary hypertension
US9005100B2 (en) 2011-12-15 2015-04-14 The Board Of Trustees Of The Leland Stanford Jr. University Apparatus and methods for treating pulmonary hypertension
US10449358B2 (en) 2012-03-26 2019-10-22 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
US9572983B2 (en) 2012-03-26 2017-02-21 Setpoint Medical Corporation Devices and methods for modulation of bone erosion
US9827036B2 (en) 2012-11-13 2017-11-28 Pulnovo Medical (Wuxi) Co., Ltd. Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US9918776B2 (en) 2012-11-13 2018-03-20 Pulnovo Medical (Wuxi) Co., Ltd. Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US10874454B2 (en) 2012-11-13 2020-12-29 Pulnovo Medical (Wuxi) Co., Ltd. Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US11241267B2 (en) 2012-11-13 2022-02-08 Pulnovo Medical (Wuxi) Co., Ltd Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US9820800B2 (en) 2012-11-13 2017-11-21 Pulnovo Medical (Wuxi) Co., Ltd. Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US9872720B2 (en) 2012-11-13 2018-01-23 Pulnovo Medical (Wuxi) Co., Ltd. Multi-pole synchronous pulmonary artery radiofrequency ablation catheter
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
US11679258B2 (en) 2013-01-15 2023-06-20 Electrocore, Inc. Stimulator for use with a mobile device
US10293160B2 (en) 2013-01-15 2019-05-21 Electrocore, Inc. Mobile phone for treating a patient with dementia
US10874857B2 (en) 2013-01-15 2020-12-29 Electrocore, Inc Mobile phone using non-invasive nerve stimulation
US11839764B2 (en) 2013-01-15 2023-12-12 Electrocore, Inc. Systems and methods for treating a medical condition with an electrical stimulation treatment regimen
US11229790B2 (en) 2013-01-15 2022-01-25 Electrocore, Inc. Mobile phone for treating a patient with seizures
US11766562B2 (en) 2013-01-15 2023-09-26 Electrocore, Inc. Nerve stimulator for use with a mobile device
US10232177B2 (en) 2013-01-15 2019-03-19 ElectroCore, LLC Mobile phone using non-invasive nerve stimulation
US11446491B2 (en) 2013-01-15 2022-09-20 Electrocore, Inc Stimulator for use with a mobile device
US11020591B2 (en) 2013-01-15 2021-06-01 Electrocore, Inc. Nerve stimulator for use with a mobile device
US9375571B2 (en) 2013-01-15 2016-06-28 ElectroCore, LLC Mobile phone using non-invasive nerve stimulation
US10376695B2 (en) 2013-01-15 2019-08-13 Electrocore, Inc. Mobile phone for stimulating the trigeminal nerve to treat disorders
US11065444B2 (en) 2013-01-15 2021-07-20 Electrocore, Inc. Mobile phone for stimulating the trigeminal nerve to treat disorders
US11406825B2 (en) 2013-01-15 2022-08-09 Electrocore, Inc Mobile phone for treating a patient with dementia
US11097102B2 (en) 2013-01-15 2021-08-24 Electrocore, Inc. Mobile phone using non-invasive nerve stimulation
US11260225B2 (en) 2013-01-15 2022-03-01 Electrocore, Inc Nerve stimulator for use with a mobile device
US9174049B2 (en) 2013-01-27 2015-11-03 ElectroCore, LLC Systems and methods for electrical stimulation of sphenopalatine ganglion and other branches of cranial nerves
US10350411B2 (en) 2013-04-28 2019-07-16 Electrocore, Inc. Devices and methods for treating medical disorders with evoked potentials and vagus nerve stimulation
US9427581B2 (en) 2013-04-28 2016-08-30 ElectroCore, LLC Devices and methods for treating medical disorders with evoked potentials and vagus nerve stimulation
US11027127B2 (en) 2013-04-28 2021-06-08 Electrocore, Inc Devices and methods for treating medical disorders with evoked potentials and vagus nerve stimulation
US10363419B2 (en) 2013-11-04 2019-07-30 Electrocore, Inc. Nerve stimulator system
US9656074B2 (en) 2013-11-04 2017-05-23 ElectroCore, LLC Nerve stimulator system
US9205258B2 (en) 2013-11-04 2015-12-08 ElectroCore, LLC Nerve stimulator system
US11311725B2 (en) 2014-10-24 2022-04-26 Setpoint Medical Corporation Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation
US11406833B2 (en) 2015-02-03 2022-08-09 Setpoint Medical Corporation Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator
US10596367B2 (en) 2016-01-13 2020-03-24 Setpoint Medical Corporation Systems and methods for establishing a nerve block
US11278718B2 (en) 2016-01-13 2022-03-22 Setpoint Medical Corporation Systems and methods for establishing a nerve block
US10695569B2 (en) 2016-01-20 2020-06-30 Setpoint Medical Corporation Control of vagal stimulation
US10314501B2 (en) 2016-01-20 2019-06-11 Setpoint Medical Corporation Implantable microstimulators and inductive charging systems
US11547852B2 (en) 2016-01-20 2023-01-10 Setpoint Medical Corporation Control of vagal stimulation
US11471681B2 (en) 2016-01-20 2022-10-18 Setpoint Medical Corporation Batteryless implantable microstimulators
US11383091B2 (en) 2016-01-25 2022-07-12 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
US10583304B2 (en) 2016-01-25 2020-03-10 Setpoint Medical Corporation Implantable neurostimulator having power control and thermal regulation and methods of use
US11173307B2 (en) 2017-08-14 2021-11-16 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
US11890471B2 (en) 2017-08-14 2024-02-06 Setpoint Medical Corporation Vagus nerve stimulation pre-screening test
US11260229B2 (en) 2018-09-25 2022-03-01 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
US11857788B2 (en) 2018-09-25 2024-01-02 The Feinstein Institutes For Medical Research Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation
US11717346B2 (en) 2021-06-24 2023-08-08 Gradient Denervation Technologies Sas Systems and methods for monitoring energy application to denervate a pulmonary artery
US11744640B2 (en) 2021-06-24 2023-09-05 Gradient Denervation Technologies Sas Systems and methods for applying energy to denervate a pulmonary artery

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