WO1997003634A1 - Oral delivery of discrete units - Google Patents
Oral delivery of discrete units Download PDFInfo
- Publication number
- WO1997003634A1 WO1997003634A1 PCT/US1996/011812 US9611812W WO9703634A1 WO 1997003634 A1 WO1997003634 A1 WO 1997003634A1 US 9611812 W US9611812 W US 9611812W WO 9703634 A1 WO9703634 A1 WO 9703634A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- active agent
- chamber
- agent formulation
- discrete units
- delivery system
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A47—FURNITURE; DOMESTIC ARTICLES OR APPLIANCES; COFFEE MILLS; SPICE MILLS; SUCTION CLEANERS IN GENERAL
- A47G—HOUSEHOLD OR TABLE EQUIPMENT
- A47G21/00—Table-ware
- A47G21/18—Drinking straws or the like
- A47G21/183—Drinking straws or the like with means for changing the flavour of the liquid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61J—CONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
- A61J7/00—Devices for administering medicines orally, e.g. spoons; Pill counting devices; Arrangements for time indication or reminder for taking medicine
- A61J7/0015—Devices specially adapted for taking medicines
- A61J7/0038—Straws
Definitions
- oral dosage form as described herein is meant the active agent formulation when placed in a discrete unit that is capable of maintaining its physical configuration and chemical integrity while housed within the delivery device.
- FIG. 1A depicts, in a cross-sectional view, one embodiment of the delivery device according to the invention.
- the device is in prepared form prior to placement in a fluid.
- Dispensing device 1 is shown in FIG. 1 A to comprise a hollow active agent formultaion chamber 10 with a first end 16 and a second end 18. Contained within chamber 10 are active agent formulation 12 and fluid passing active agent formulation retainer 14.
- the fluid passing active agent formulation retainer 14 comprises a restriction 24 and a one-way plug 28.
- the diameter of opening 20 is smaller than the plug 28.
- the restriction is made by crimping the end 16 of chamber 10.
- Second end 18 of chamber 10 has an active agent formulation retainer 26 for preventing release of plug 28.
- FIG. 1A depicts, in a cross-sectional view, one embodiment of the delivery device according to the invention.
- the device is in prepared form prior to placement in a fluid.
- Dispensing device 1 is shown in FIG. 1 A to comprise a hollow active agent formultai
- the patient sips on the second end 18 of the device and an admixture of fluid 30 and active agent formulation 12 is delivered through opening 22 and into the patient's mouth.
- the plug 28 serves as a one ⁇ way valve.
- suction is applied through the tubular member 10
- the plug 28 is deformed, thereby permitting fluid to flow around the plug 28 as shown by arrows 32.
- suction is removed, the plug 28 relaxes and automatically seals the chamber 10 (see FIG. 3B).
- the plug 28, which has a density of less than 1 moves up the elongated tubular member, thereby aiding in delivery of the active agent formulation 12.
- the position of plug 28 in chamber 10 serves as an indicator of approximately how much of the active agent formulation 12 has actually been delivered.
- FIG. 3A shows delivery device 1 after delivery of the active agent formulation has essentially been completed.
- the plug 28 is seated adjacent the opening 22 but it does not leave the chamber 10 since the diameter of the opening is less than the diameter of the plug 28 (see FIG 3B).
- the position of plug 28 adjacent the opening 22 serves as an indication that the entire active agent formulation 12 has been delivered.
- the end cap 64 may have a cross-shaped inner member 70, however, any conveniently shaped inner member is contemplated that will allow for passage of fluid but will not permit displacement of the one-way plug 28.
- End cap 66 placed over the second end 72 of the chamber 60, is designed to allow free passage of liquid when suction is applied by the patient, but to provide a means for closing the end of the device prior to use. Accordingly, rotary valve 74 is placed over end cap 66.
- FIG. 5C The top view of both end cap 66 and rotary valve 74 are shown in FIG. 5C. This configuration allows for free passage of fluid when the open sections 76 are aligned with each other and for prevention of fluid flow when the open sections 76 are aligned with closed sections 78.
- FIG. 5D is a top view of the device of FIG. 5A when the open sections 76 of the valve 74 are aligned with the closed sections 78 of the end cap 66.
- FIG. 6 is a cross-sectional view of still another embodiment of the device of the invention in prepared form prior to placement in the fluid.
- an active agent formulation chamber 90 is situated on top of an elongated tubular member 92 and separated by a fluid passing active agent formulation retainer 94, in this case a porous plug.
- a fluid passing active agent formulation retainer 94 in this case a porous plug.
- the active agent may be in liquid form and may 5 be contained within a soft gelatin capsule or within a solid oral dosage form.
- dosage forms may include, matrix or other types of tablets, pellets and elongated tablets where the height to diameter ratio exceeds one, capsules, elementary osmotic pumps, such as those described in US Patent No. 3,845,770, mini osmotic pumps such as those described in US Patent Nos. o 3,995,631 , 4,034,756, and 4,111 ,202, and multichamber osmotic systems referred to as push-pull and push-melt osmotic pumps, such as those described in US Patent Nos. 4,320,759, 4,327,725, 4,449,983, and 4,765,989 all of which are incorporated herein by reference.
- the active drug that can be delivered includes antibiotics, antiviral agents, anepileptics, analgesics, anti-inflammatory agents and bronchodilators, and may be inorganic and organic compounds, including, without limitation, drugs which act on the peripheral nerves, adrenergic receptors, cholinergic receptors, the skeletal muscles, the cardiovascular system, smooth muscles, the blood circulatory system, synoptic sites, neuroeffector junctional sites, endocrine and hormone systems, the immunological system, the reproductive system, the skeletal system, autacoid systems, the alimentary and excretory systems, the histamine system and the central nervous system.
- antibiotics antibiotics, antiviral agents, anepileptics, analgesics, anti-inflammatory agents and bronchodilators, and may be inorganic and organic compounds, including, without limitation, drugs which act on the peripheral nerves, adrenergic receptors, cholinergic receptors, the skeletal muscles, the cardiovascular system, smooth muscles, the blood circulatory
- Suitable agents may be selected from, for example, polysaccharides, steroids, hypnotics and sedatives, psychic energizers, tranquilizers, anticonvulsants, muscle relaxants, antiparkinson agents, analgesics, anti-inflammatories, muscle contractants, antimicrobials, antimalarials, hormonal agents including contraceptives, sympathomimetics, polypeptides and proteins capable of eliciting physiological effects, diuretics, lipid regulating agents, antiandrogenic agents, antiparasitics, neoplasties, antineoplastics, hypoglycemics, nutritional agents and supplements, growth supplements, fats, ophthalmics, antienteritis agents, electrolytes and diagnostic agents.
- proteins and peptides which include, but are not limited to, insulin, colchicine, glucagon, thyroid stimulating hormone, parathyroid and pituitary hormones, calcitonin, renin, prolactin, corticotrophin, thyrotropic hormone, follicle stimulating hormone, chorionic gonadotropin, gonadotropin releasing hormone, bovine somatotropin, porcine somatropin, oxytocin, vasopressin, prolactin, somatostatin, lypressin, pancreozymin and luteinizing hormone.
- agents can be in various forms, such as soluble and insoluble charged or uncharged molecules, components of molecular complexes or nonirritating, pharmacologically acceptable salts.
- Representative materials for forming devices including the active agent formulation chamber, the elongated tubular member, the end caps and tabs include, without limitation, paper, plastic such as propylene/styrene copolymers, polyproylene, high density polyethylene, low density polyethylene and the like.
- the devices usually have an inner diameter of between about 3 and 8 mm and a wall thickness of between about 0.1 and 0.4 mm.
- the devices are between about 10 and 30 cm in length.
- the plug end of the straw was placed into a glass of water and the protective gelatin capsule on the top of the straw was removed.
- the 600 mg of Micro-K particles were sucked into the mouth and easily swallowed.
- Example 2 The device was prepared according to Example 1 , but instead of Micro-K, the contents of a Contact® 12 hour capsule (SmithKline Beechem), an over the counter continuous action nasal decongestant/antihistamine containing 25 mg phenylpropanolamine and 12 mg chlorpheniramine maleate were inserted into the straw.
- the microparticulates were in the range of between about 0.5 and 1.0 mm. The particulates were sucked into the mouth as described in Example 1.
- Example 3 A delivery device according to the present invention was prepared as follows. Jumbo size straws with an inside diameter of 0.21 inches and a length of 6 inches were heat sealed at one end. The seal was partially cut off so that the orifice had a diameter of less than 5 mm.
Abstract
Description
Claims
Priority Applications (11)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
NZ313010A NZ313010A (en) | 1995-07-21 | 1996-07-17 | Oral delivery of discrete units mixed with a fluid in a hollow active agent formulation chamber |
JP50681697A JP3818664B2 (en) | 1995-07-21 | 1996-07-17 | Oral delivery of individual units |
BR9609696A BR9609696A (en) | 1995-07-21 | 1996-07-17 | Oral administration separate units |
DK96924555T DK0840591T3 (en) | 1995-07-21 | 1996-07-17 | Oral delivery system for discrete devices |
EP96924555A EP0840591B1 (en) | 1995-07-21 | 1996-07-17 | Oral delivery system for delivery of discrete units |
AT96924555T ATE199638T1 (en) | 1995-07-21 | 1996-07-17 | DEVICE FOR ORAL ADMINISTRATION OF DISCRETE UNITS |
DE69612098T DE69612098T2 (en) | 1995-07-21 | 1996-07-17 | DEVICE FOR ORAL ADMINISTRATION OF DISCRETE UNITS |
CA002226267A CA2226267C (en) | 1995-07-21 | 1996-07-17 | Device and method for oral delivery of an active agent formulation in the form of discrete units |
AU64980/96A AU713120B2 (en) | 1995-07-21 | 1996-07-17 | Oral delivery of discrete units |
HK99100704A HK1015671A1 (en) | 1995-07-21 | 1999-02-22 | Oral delivery of discrete units |
GR20010400700T GR3035850T3 (en) | 1995-07-21 | 2001-05-11 | Oral delivery of discrete units |
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US131995P | 1995-07-21 | 1995-07-21 | |
US60/001,319 | 1995-07-21 | ||
US58254496A | 1996-01-03 | 1996-01-03 | |
US08/582,544 | 1996-01-03 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO1997003634A1 true WO1997003634A1 (en) | 1997-02-06 |
Family
ID=26668856
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US1996/011812 WO1997003634A1 (en) | 1995-07-21 | 1996-07-17 | Oral delivery of discrete units |
Country Status (17)
Country | Link |
---|---|
EP (2) | EP0988850B1 (en) |
JP (1) | JP3818664B2 (en) |
KR (1) | KR100449538B1 (en) |
CN (1) | CN1113640C (en) |
AT (1) | ATE199638T1 (en) |
AU (1) | AU713120B2 (en) |
BR (1) | BR9609696A (en) |
CA (1) | CA2226267C (en) |
DE (1) | DE69612098T2 (en) |
DK (2) | DK0988850T3 (en) |
ES (2) | ES2228398T3 (en) |
GR (1) | GR3035850T3 (en) |
HK (1) | HK1015671A1 (en) |
NZ (2) | NZ313010A (en) |
PT (1) | PT840591E (en) |
TW (1) | TW347339B (en) |
WO (1) | WO1997003634A1 (en) |
Cited By (20)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO1998017227A1 (en) | 1996-10-18 | 1998-04-30 | Alza Corporation | Multiple flow path device for oral delivery of discrete units |
WO1998017228A1 (en) * | 1996-10-18 | 1998-04-30 | Alza Corporation | Closure system for an active agent delivery device |
WO1998034598A2 (en) * | 1997-02-07 | 1998-08-13 | Gist-Brocades B.V. | Homogeneous granulated formulations for dose sipping technology |
WO1998051259A1 (en) | 1997-05-16 | 1998-11-19 | Alza Corporation | Flow controller configurations for an active agent delivery device |
EP0942656A1 (en) * | 1996-10-10 | 1999-09-22 | Peter Baron | Method and apparatus for producing a flavoured beverage |
US6024721A (en) * | 1996-10-18 | 2000-02-15 | Alza Corporation | Mixing system for an active agent delivery device |
US6200622B1 (en) | 1997-03-14 | 2001-03-13 | Good Humor - Breyers Ice Cream, Division Of Conopco | Frozen food product |
WO2006136384A1 (en) * | 2005-06-22 | 2006-12-28 | Grünenthal GmbH | Cap for a drinking straw, comprising a cylindrical internal spike |
CN101537919A (en) * | 2009-04-22 | 2009-09-23 | 汕头市润科生物工程有限公司 | Apparatus for drinking solid material |
EP2163242A1 (en) | 2008-09-10 | 2010-03-17 | Sandoz AG | Capsule with soluble blocking element |
WO2010029095A2 (en) * | 2008-09-10 | 2010-03-18 | Sandoz Ag | Capsule with soluble blocking element |
US8052982B2 (en) | 1998-07-20 | 2011-11-08 | Peptech Animal Health Pty Limited | Bioimplant formulation comprising lecithin and stearin |
US8334003B2 (en) | 1996-10-10 | 2012-12-18 | Unistraw Patent Holdings Limited | Drink flavouring straw |
WO2014140199A1 (en) * | 2013-03-14 | 2014-09-18 | Unistraw Holdings Pte. Ltd. | Drinking straw with piercing end |
US8919594B2 (en) | 2007-01-31 | 2014-12-30 | Sands Innovations Pty Ltd | Dispensing container |
US8980348B2 (en) | 2002-05-31 | 2015-03-17 | Unistraw Holdings Pte. Ltd. | Drink flavouring straw |
US9005684B2 (en) | 2006-03-02 | 2015-04-14 | Unistraw Patent Holdings Limited | Drinking straw with integral filters |
US9375108B2 (en) | 2007-04-10 | 2016-06-28 | Sandoz Ag | Device for the oral application of a substance |
USD767931S1 (en) | 2013-09-12 | 2016-10-04 | Unistraw Holdings Pte. Ltd. | Beverage straw end with a beak |
EP3585320B1 (en) | 2017-02-24 | 2022-07-27 | Bolton Medical, Inc. | Delivery system for radially constricting a stent graft |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
RU2005138854A (en) * | 2003-05-14 | 2006-07-27 | Куреха Корпорейшн (Jp) | ACCOMMODATION CASE FOR SWALLOWING A SOLID FORM FOR ORAL RECEPTION, CONTAINER FOR ACCOMMODATION CASE AND INGESTION METHOD |
DE10342513A1 (en) * | 2003-09-12 | 2005-05-12 | Gruenenthal Gmbh | Dosage form for oral administration of active ingredients, vitamins and / or nutrients, kit and use |
DE10342514A1 (en) * | 2003-09-12 | 2005-04-07 | Grünenthal GmbH | Dosage form for oral administration of active ingredients, vitamins and / or nutrients, kit and use |
US20060034886A1 (en) * | 2004-07-23 | 2006-02-16 | Ward Bennett C | Bonded fiber structures for use in controlling fluid flow |
DE102005004257A1 (en) * | 2005-01-28 | 2006-08-24 | Grünenthal GmbH | Process for making a drinking straw with controller |
DE102005004256A1 (en) * | 2005-01-28 | 2006-08-10 | Grünenthal GmbH | Drinking straw with a stiffener |
US20080312587A1 (en) * | 2005-06-10 | 2008-12-18 | Gruenethal Gmbh | System for the Oral Administration of Solids to Persons Suffering from Dementia |
DE202011104802U1 (en) * | 2011-08-20 | 2012-01-26 | Christian Kober | Straw for the measurement of harmful substances or of party drugs in drinks |
US9017749B2 (en) | 2011-12-21 | 2015-04-28 | Babatope Sewande Ayeni | Flavored straw with a flavor delivery system |
DE202012005997U1 (en) | 2012-06-20 | 2012-07-18 | Claus Linder | Vessel for drinks and liquids of any kind for the measurement of harmful substances or narcotic drugs and party drugs in drinks |
US9005108B2 (en) * | 2012-09-27 | 2015-04-14 | Palo Alto Research Center Incorporated | Multiple reservoir drug delivery device and methods |
CN105030004B (en) * | 2015-05-06 | 2017-01-04 | 曹杨 | A kind of storage type suction pipe |
WO2021062987A1 (en) * | 2019-09-30 | 2021-04-08 | 上海汉都医药科技有限公司 | Drug accommodating device of solid oral formulation, and oral administration and delivery apparatus comprising same |
Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US2436505A (en) * | 1945-08-24 | 1948-02-24 | Rall John H Du | Pill douser |
US2867536A (en) * | 1954-05-07 | 1959-01-06 | Mead Bruce Ronald | Flavor-containing drinking straw |
DE1906964A1 (en) * | 1969-02-07 | 1970-08-20 | Ernst Ruediger | Drinking straw |
US3610483A (en) * | 1969-12-01 | 1971-10-05 | Ralph Visconti | Dispenser with liquid-impervious vent |
US4792333A (en) * | 1986-11-04 | 1988-12-20 | Strawdose, Inc. | Unit dose drug package and administering device |
EP0383503A1 (en) * | 1989-02-17 | 1990-08-22 | Eli Lilly And Company | Delivery device for orally administered therapeutic agents |
-
1996
- 1996-07-17 DK DK00200063T patent/DK0988850T3/en active
- 1996-07-17 EP EP00200063A patent/EP0988850B1/en not_active Expired - Lifetime
- 1996-07-17 AU AU64980/96A patent/AU713120B2/en not_active Expired
- 1996-07-17 NZ NZ313010A patent/NZ313010A/en not_active IP Right Cessation
- 1996-07-17 CN CN96195726A patent/CN1113640C/en not_active Expired - Lifetime
- 1996-07-17 WO PCT/US1996/011812 patent/WO1997003634A1/en active IP Right Grant
- 1996-07-17 ES ES00200063T patent/ES2228398T3/en not_active Expired - Lifetime
- 1996-07-17 ES ES96924555T patent/ES2154829T3/en not_active Expired - Lifetime
- 1996-07-17 DK DK96924555T patent/DK0840591T3/en active
- 1996-07-17 BR BR9609696A patent/BR9609696A/en not_active IP Right Cessation
- 1996-07-17 AT AT96924555T patent/ATE199638T1/en active
- 1996-07-17 KR KR1019970709987A patent/KR100449538B1/en not_active IP Right Cessation
- 1996-07-17 JP JP50681697A patent/JP3818664B2/en not_active Expired - Lifetime
- 1996-07-17 PT PT96924555T patent/PT840591E/en unknown
- 1996-07-17 DE DE69612098T patent/DE69612098T2/en not_active Expired - Lifetime
- 1996-07-17 CA CA002226267A patent/CA2226267C/en not_active Expired - Lifetime
- 1996-07-17 EP EP96924555A patent/EP0840591B1/en not_active Expired - Lifetime
- 1996-12-18 TW TW085115610A patent/TW347339B/en not_active IP Right Cessation
-
1999
- 1999-02-01 NZ NZ333997A patent/NZ333997A/en not_active IP Right Cessation
- 1999-02-22 HK HK99100704A patent/HK1015671A1/en not_active IP Right Cessation
-
2001
- 2001-05-11 GR GR20010400700T patent/GR3035850T3/en unknown
Patent Citations (6)
Publication number | Priority date | Publication date | Assignee | Title |
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US2436505A (en) * | 1945-08-24 | 1948-02-24 | Rall John H Du | Pill douser |
US2867536A (en) * | 1954-05-07 | 1959-01-06 | Mead Bruce Ronald | Flavor-containing drinking straw |
DE1906964A1 (en) * | 1969-02-07 | 1970-08-20 | Ernst Ruediger | Drinking straw |
US3610483A (en) * | 1969-12-01 | 1971-10-05 | Ralph Visconti | Dispenser with liquid-impervious vent |
US4792333A (en) * | 1986-11-04 | 1988-12-20 | Strawdose, Inc. | Unit dose drug package and administering device |
EP0383503A1 (en) * | 1989-02-17 | 1990-08-22 | Eli Lilly And Company | Delivery device for orally administered therapeutic agents |
Cited By (36)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0942656A1 (en) * | 1996-10-10 | 1999-09-22 | Peter Baron | Method and apparatus for producing a flavoured beverage |
US8334003B2 (en) | 1996-10-10 | 2012-12-18 | Unistraw Patent Holdings Limited | Drink flavouring straw |
US6482451B1 (en) | 1996-10-10 | 2002-11-19 | Peter Baron | Apparatus for producing a flavored beverage |
EP0942656A4 (en) * | 1996-10-10 | 2000-05-17 | Peter Baron | Method and apparatus for producing a flavoured beverage |
US6096003A (en) * | 1996-10-18 | 2000-08-01 | Alza Corporation | Closure system for an active agent delivery device |
US5910321A (en) * | 1996-10-18 | 1999-06-08 | Alza Corporation | Multiple flow path device for oral delivery of discrete units |
WO1998017228A1 (en) * | 1996-10-18 | 1998-04-30 | Alza Corporation | Closure system for an active agent delivery device |
US6024721A (en) * | 1996-10-18 | 2000-02-15 | Alza Corporation | Mixing system for an active agent delivery device |
WO1998017227A1 (en) | 1996-10-18 | 1998-04-30 | Alza Corporation | Multiple flow path device for oral delivery of discrete units |
US6572582B1 (en) | 1996-10-18 | 2003-06-03 | Alza Corporation | Mixing system for an active agent delivery device |
AU729769B2 (en) * | 1996-10-18 | 2001-02-08 | Alza Corporation | Closure system for an active agent delivery device |
WO1998034598A3 (en) * | 1997-02-07 | 1998-11-19 | Gist Brocades Bv | Homogeneous granulated formulations for dose sipping technology |
WO1998034598A2 (en) * | 1997-02-07 | 1998-08-13 | Gist-Brocades B.V. | Homogeneous granulated formulations for dose sipping technology |
US6200622B1 (en) | 1997-03-14 | 2001-03-13 | Good Humor - Breyers Ice Cream, Division Of Conopco | Frozen food product |
US6224908B1 (en) | 1997-05-16 | 2001-05-01 | Alza Corporation | Flow controller configurations for an active agent delivery device |
AU733022B2 (en) * | 1997-05-16 | 2001-05-03 | Alza Corporation | Flow controller configurations for an active agent delivery device |
US6103265A (en) * | 1997-05-16 | 2000-08-15 | Alza Corporation | Flow controller configurations for an active agent delivery device |
WO1998051259A1 (en) | 1997-05-16 | 1998-11-19 | Alza Corporation | Flow controller configurations for an active agent delivery device |
US5985324A (en) * | 1997-05-16 | 1999-11-16 | Alza Corporation | Flow controller configurations for an active agent delivery device |
US8052982B2 (en) | 1998-07-20 | 2011-11-08 | Peptech Animal Health Pty Limited | Bioimplant formulation comprising lecithin and stearin |
US8980348B2 (en) | 2002-05-31 | 2015-03-17 | Unistraw Holdings Pte. Ltd. | Drink flavouring straw |
WO2006136384A1 (en) * | 2005-06-22 | 2006-12-28 | Grünenthal GmbH | Cap for a drinking straw, comprising a cylindrical internal spike |
US9005684B2 (en) | 2006-03-02 | 2015-04-14 | Unistraw Patent Holdings Limited | Drinking straw with integral filters |
US8919594B2 (en) | 2007-01-31 | 2014-12-30 | Sands Innovations Pty Ltd | Dispensing container |
US9375108B2 (en) | 2007-04-10 | 2016-06-28 | Sandoz Ag | Device for the oral application of a substance |
WO2010029095A2 (en) * | 2008-09-10 | 2010-03-18 | Sandoz Ag | Capsule with soluble blocking element |
EP2163242A1 (en) | 2008-09-10 | 2010-03-17 | Sandoz AG | Capsule with soluble blocking element |
WO2010029095A3 (en) * | 2008-09-10 | 2010-08-19 | Sandoz Ag | Capsule with soluble blocking element |
US9629810B2 (en) | 2008-09-10 | 2017-04-25 | Sandoz Ag | Capsule with soluble blocking element |
CN101537919B (en) * | 2009-04-22 | 2014-02-19 | 广东润科生物工程有限公司 | Apparatus for drinking solid material |
CN101537919A (en) * | 2009-04-22 | 2009-09-23 | 汕头市润科生物工程有限公司 | Apparatus for drinking solid material |
CN105007783A (en) * | 2013-03-14 | 2015-10-28 | 优尼斯卓控股私人有限公司 | Drinking straw with piercing end |
WO2014140199A1 (en) * | 2013-03-14 | 2014-09-18 | Unistraw Holdings Pte. Ltd. | Drinking straw with piercing end |
US9833092B2 (en) | 2013-03-14 | 2017-12-05 | Unistraw Holdings Pte. Ltd. | Drinking straw with piercing end |
USD767931S1 (en) | 2013-09-12 | 2016-10-04 | Unistraw Holdings Pte. Ltd. | Beverage straw end with a beak |
EP3585320B1 (en) | 2017-02-24 | 2022-07-27 | Bolton Medical, Inc. | Delivery system for radially constricting a stent graft |
Also Published As
Publication number | Publication date |
---|---|
EP0988850A2 (en) | 2000-03-29 |
BR9609696A (en) | 1999-03-23 |
ATE199638T1 (en) | 2001-03-15 |
NZ313010A (en) | 1999-03-29 |
EP0840591A1 (en) | 1998-05-13 |
CA2226267A1 (en) | 1997-02-06 |
EP0988850A3 (en) | 2000-05-17 |
AU6498096A (en) | 1997-02-18 |
KR19990028664A (en) | 1999-04-15 |
GR3035850T3 (en) | 2001-08-31 |
AU713120B2 (en) | 1999-11-25 |
CN1113640C (en) | 2003-07-09 |
NZ333997A (en) | 1999-03-29 |
DE69612098D1 (en) | 2001-04-19 |
TW347339B (en) | 1998-12-11 |
HK1015671A1 (en) | 1999-10-22 |
ES2228398T3 (en) | 2005-04-16 |
ES2154829T3 (en) | 2001-04-16 |
CN1191476A (en) | 1998-08-26 |
CA2226267C (en) | 2008-01-22 |
DK0840591T3 (en) | 2001-04-17 |
EP0988850B1 (en) | 2004-09-22 |
DK0988850T3 (en) | 2005-01-24 |
EP0840591B1 (en) | 2001-03-14 |
JPH11510066A (en) | 1999-09-07 |
PT840591E (en) | 2001-06-29 |
DE69612098T2 (en) | 2001-06-21 |
KR100449538B1 (en) | 2004-12-17 |
JP3818664B2 (en) | 2006-09-06 |
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