WO1997034816A1 - Packaging for two or more substances to be mixed together - Google Patents

Packaging for two or more substances to be mixed together Download PDF

Info

Publication number
WO1997034816A1
WO1997034816A1 PCT/EP1997/001197 EP9701197W WO9734816A1 WO 1997034816 A1 WO1997034816 A1 WO 1997034816A1 EP 9701197 W EP9701197 W EP 9701197W WO 9734816 A1 WO9734816 A1 WO 9734816A1
Authority
WO
WIPO (PCT)
Prior art keywords
compartments
packaging
packaging according
plate
substances
Prior art date
Application number
PCT/EP1997/001197
Other languages
German (de)
French (fr)
Inventor
Robert Becker
Ulrich Brauns
William Frank Tyldesley
William Ronald Stuart Baxter
Original Assignee
Dr. Karl Thomae Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dr. Karl Thomae Gmbh filed Critical Dr. Karl Thomae Gmbh
Priority to AU21545/97A priority Critical patent/AU2154597A/en
Publication of WO1997034816A1 publication Critical patent/WO1997034816A1/en

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D81/00—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents
    • B65D81/32—Containers, packaging elements, or packages, for contents presenting particular transport or storage problems, or adapted to be used for non-packaging purposes after removal of contents for packaging two or more different materials which must be maintained separate prior to use in admixture
    • B65D81/3294—Thermoformed trays or the like with a plurality of recesses for different materials located in different recesses
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B65—CONVEYING; PACKING; STORING; HANDLING THIN OR FILAMENTARY MATERIAL
    • B65D—CONTAINERS FOR STORAGE OR TRANSPORT OF ARTICLES OR MATERIALS, e.g. BAGS, BARRELS, BOTTLES, BOXES, CANS, CARTONS, CRATES, DRUMS, JARS, TANKS, HOPPERS, FORWARDING CONTAINERS; ACCESSORIES, CLOSURES, OR FITTINGS THEREFOR; PACKAGING ELEMENTS; PACKAGES
    • B65D75/00—Packages comprising articles or materials partially or wholly enclosed in strips, sheets, blanks, tubes, or webs of flexible sheet material, e.g. in folded wrappers
    • B65D75/52—Details
    • B65D75/58—Opening or contents-removing devices added or incorporated during package manufacture
    • B65D75/5827—Tear-lines provided in a wall portion
    • B65D75/585—Tear-lines provided in a wall portion the tear-lines being broken by deformation or bending

Definitions

  • This invention relates to packaging for two or more substances to be mixed together.
  • the packaging for a two component adhesive system comprises separate containers for a bonding agent and a curing agent which is mixed with the bonding agent immediately before use.
  • packaging for two or more substances to be mixed together, the packaging comprising at least a pair of compartments, each for retaining a respective one of the substances, and opening means for opening the compartments to allow the substances to be discharged therefrom, wherein the opening means is so arranged as to be operable to open the compartments substantially simultaneously, and that the opening of either one of the compartments by the opening means cannot be achieved without also opening the other compartments.
  • packaging in accordance with the invention is particularly suitable for medication in the form of a two-part system comprising a pair of compartments.
  • each compartment could contain a respective drug.
  • one compartment could contain a drug and the other an agent to assist in the dissolving of the drug in water.
  • the opening means is operable to open the compartments at regions on the same side of the packaging so that, with the packaging appropriately orientated, the substances are discharged from the compartments simultaneousl .
  • the opening means comprises a zone of weakness in the packaging, and the packaging is flexible so that appropriate flexing of the packaging causes the latter to be broken open at said zone of weakness.
  • each compartment has a respective zone of weakness.
  • the packaging comprises a plate from which the compartments depend, the plate having at least two apertures through which the substances can be introduced into the compartments thereby to charge the packaging.
  • the apertures on the plate are sealed by one or more pieces of sheet material.
  • each aperture is preferably sealed by a respective one of two separate pieces of sheet material.
  • the latter feature prevents the substance in one compartment migrating into the other compartment along any interface between sheet material and plate, and also enables one compartment to be sealed before the other is filled, thereby preventing contamination of the substance in said first filled compartment during the filling of the other compartment.
  • the plate is foldable about an axis, and the zones of weakness on the compartments run parallel to said axis.
  • the packaging contains a drug and an agent to facilitate the dissolving of the drug
  • a user can release those substances into a beaker of water simply by holding the plate above the beaker with the zone(s) of weakness along the bottom of the packaging, and then folding the plate to open both compartments and thereby discharge the substances into the beaker.
  • the compartments are elongate so that, when the plate is folded to open the compartments, the latter act as chutes for the substances being discharged.
  • the compartments optionally are flattened at the end to help locate the user's fingers on the underside of the plate.
  • a handle is located at one end of the plate.
  • the handle preferably is designed as a mould or impression in a way that it can be easily hold between thumb and forefinger.
  • the invention also lies in packaging as hereinabove described, wherein one compartment of the packaging contains a solid drug to be administered by, and the other compartment contains an agent to facilitate the dissolving of the drug.
  • Figure 1 is a perspective view of the packaging modification
  • Figure 2 shows the packaging corresponding to Figure 1 when inverted
  • Figure 3 is a view corresponding to Figure 1, and shows the packaging when sealed;
  • Figure 4 is a view corresponding to Figure 1 of the packaging after breaking along the line of weakness and discharging the content
  • Figure 5 is a view corresponding to Figure 7 of the packaging after breaking along the line of weakness and discharging the content
  • Figure 6 is a view corresponding to Figure 7, and shows the packaging when inverted and sealed;
  • Figure 7 is a perspective view of the packaging modification 2
  • Figure 8 shows the packaging corresponding to Figure 7 when inverted
  • the packaging shown in the drawings is intended to be hand ⁇ held and used in the administration of a powdered drug which is to be dissolved in a beaker of water (not shown) .
  • the packaging is intended to contain both the drug and an agent which needs to be mixed with the drug immediately prior to administration, but which needs to be kept separate from the drug during storage.
  • Such an agent may for example be an agent for facilitating the dissolving of the drug in water.
  • the packaging comprises a polystyrene body having a backing plate 1 from which two cylindrical compartments 2 and 3 project.
  • compartments 2 and 3 are flatted at every end portion (4,5,6,7) in order to facilitate the holding of the device by a user by locating a respective one of the user's fingers on the flatted end portions.
  • a handle 8 is located at one end of backing plate 1.
  • the handle 8 preferably is designed as a mould 9 or impression in a way that it can be easily hold between thumb and forefinger by locating the user's thumb in the mould or impression and locating the forefinger on the underside of the mould or impression.
  • Each of the compartments 2 and 3 has a respective line of weakness, 16 and 18, which extends laterally across the middle of its compartment.
  • the lines 16 and 18 are aligned with each other.
  • the lines of weakness 16 and 18 extending laterally across the compartments 2 and 3 can also be located outside the middle of the compartments, subdividing the longitudinal axis of the compartments 2 and 3 in in a short and one longer part in a ratio between 0.5:6 and 2:6, preferably in a ratio of 1:6.
  • the short part of the subdivided longitudinal axis is faced to the handle ( Figure 7) .
  • the face of the plate 1 opposite the compartments 2 and 3 includes apertures 22 and 24 ( Figure 1, 8) through which the compartments 2 and 3 can be filled, one with a drug, the other with the agent to assist dissolving. Once so filled, the compartments 2 and 3 are sealed by means of foil seals 26 and 28 which are hea -sealed onto the plate 1 so as to cover the apertures 22 and 24 ( Figure 3 and 6) .
  • Each of the compartments 2 and 3 is thus broken in two parts, and the two parts of each compartment are inclined so that the contents thereof are discharged under the influence of gravity.

Abstract

Disclosed is a packaging for two or more substances to be mixed together, the packaging comprising at least a pair of compartments (2, 3), each for retaining a respective one of the substances, and opening means (16, 18) for opening the compartments to allow the substances to be discharged therefrom, wherein the opening means is so arranged as to be operable to open the compartments substantially simultaneously, and that the opening of either one of the compartments (2, 3) by the opening means cannot be achieved without also opening the other compartments.

Description

PACKAGING FOR TWO OR MORE SUBSTANCES TO BE NIXED TOGETHER
Field of the Invention
This invention relates to packaging for two or more substances to be mixed together.
Background to the Invention
Many products are supplied in the form of two component systems, in which constituents of the products are provided in separate containers. For example, the packaging for a two component adhesive system comprises separate containers for a bonding agent and a curing agent which is mixed with the bonding agent immediately before use.
One disadvantage of such packaging is that the user can erroneously mix the constituents together in the wrong proportions or even omit to use either one of the constituents altogether. This potential problem applies to all packaging for multi-component systems in which it is important for all the constituents to be mixed together, and in the correct proportions.
Consequently, it is very difficult to provide medication in the form of a two component system which can be supplied directly to a patient for self administration.
Summary of the Invention
According to the invention, there is provided packaging for two or more substances to be mixed together, the packaging comprising at least a pair of compartments, each for retaining a respective one of the substances, and opening means for opening the compartments to allow the substances to be discharged therefrom, wherein the opening means is so arranged as to be operable to open the compartments substantially simultaneously, and that the opening of either one of the compartments by the opening means cannot be achieved without also opening the other compartments.
Thus, the invention helps to ensure that the end user dispenses both the substances, or at least makes it difficult for the user to use one substance without also releasing the other. As a result, packaging in accordance with the invention is particularly suitable for medication in the form of a two-part system comprising a pair of compartments.
In an example of such a system, each compartment could contain a respective drug. In another example, one compartment could contain a drug and the other an agent to assist in the dissolving of the drug in water.
Preferably, the opening means is operable to open the compartments at regions on the same side of the packaging so that, with the packaging appropriately orientated, the substances are discharged from the compartments simultaneousl .
This further reduces the likelihood of the user failing to mix both substances.
Preferably, the opening means comprises a zone of weakness in the packaging, and the packaging is flexible so that appropriate flexing of the packaging causes the latter to be broken open at said zone of weakness. Preferably, each compartment has a respective zone of weakness.
Preferably, the packaging comprises a plate from which the compartments depend, the plate having at least two apertures through which the substances can be introduced into the compartments thereby to charge the packaging. Preferably, with the packaging charged, the apertures on the plate are sealed by one or more pieces of sheet material. In this case, each aperture is preferably sealed by a respective one of two separate pieces of sheet material.
The latter feature prevents the substance in one compartment migrating into the other compartment along any interface between sheet material and plate, and also enables one compartment to be sealed before the other is filled, thereby preventing contamination of the substance in said first filled compartment during the filling of the other compartment.
Preferably, the plate is foldable about an axis, and the zones of weakness on the compartments run parallel to said axis.
Thus, if the packaging contains a drug and an agent to facilitate the dissolving of the drug, a user can release those substances into a beaker of water simply by holding the plate above the beaker with the zone(s) of weakness along the bottom of the packaging, and then folding the plate to open both compartments and thereby discharge the substances into the beaker.
Preferably, the compartments are elongate so that, when the plate is folded to open the compartments, the latter act as chutes for the substances being discharged.
In order to facilitate manipulation of the plate, the compartments optionally are flattened at the end to help locate the user's fingers on the underside of the plate.
In another modification of the invention a handle is located at one end of the plate. The handle preferably is designed as a mould or impression in a way that it can be easily hold between thumb and forefinger. The invention also lies in packaging as hereinabove described, wherein one compartment of the packaging contains a solid drug to be administered by, and the other compartment contains an agent to facilitate the dissolving of the drug.
Brief Description of the Drawings
An example of packaging in accordance with the invention will now be described with reference to the accompanying drawings in which:
Figure 1 is a perspective view of the packaging modification
1;
Figure 2 shows the packaging corresponding to Figure 1 when inverted;
Figure 3 is a view corresponding to Figure 1, and shows the packaging when sealed;
Figure 4 is a view corresponding to Figure 1 of the packaging after breaking along the line of weakness and discharging the content;
Figure 5 is a view corresponding to Figure 7 of the packaging after breaking along the line of weakness and discharging the content;
Figure 6 is a view corresponding to Figure 7, and shows the packaging when inverted and sealed;
Figure 7 is a perspective view of the packaging modification 2;
Figure 8 shows the packaging corresponding to Figure 7 when inverted; Detailed Description
The packaging shown in the drawings is intended to be hand¬ held and used in the administration of a powdered drug which is to be dissolved in a beaker of water (not shown) . The packaging is intended to contain both the drug and an agent which needs to be mixed with the drug immediately prior to administration, but which needs to be kept separate from the drug during storage. Such an agent may for example be an agent for facilitating the dissolving of the drug in water.
With reference to Figures 1 and 2 and Figures 7 and 8 the packaging comprises a polystyrene body having a backing plate 1 from which two cylindrical compartments 2 and 3 project.
In modification 1 (Figure 2) of the invention the compartments 2 and 3 are flatted at every end portion (4,5,6,7) in order to facilitate the holding of the device by a user by locating a respective one of the user's fingers on the flatted end portions.
In modification 2 (Figure 7) of the invention a handle 8 is located at one end of backing plate 1. The handle 8 preferably is designed as a mould 9 or impression in a way that it can be easily hold between thumb and forefinger by locating the user's thumb in the mould or impression and locating the forefinger on the underside of the mould or impression.
Each of the compartments 2 and 3 has a respective line of weakness, 16 and 18, which extends laterally across the middle of its compartment. The lines 16 and 18 are aligned with each other. The lines of weakness 16 and 18 extending laterally across the compartments 2 and 3 can also be located outside the middle of the compartments, subdividing the longitudinal axis of the compartments 2 and 3 in in a short and one longer part in a ratio between 0.5:6 and 2:6, preferably in a ratio of 1:6. Preferably the short part of the subdivided longitudinal axis is faced to the handle (Figure 7) .
The face of the plate 1 opposite the compartments 2 and 3 includes apertures 22 and 24 (Figure 1, 8) through which the compartments 2 and 3 can be filled, one with a drug, the other with the agent to assist dissolving. Once so filled, the compartments 2 and 3 are sealed by means of foil seals 26 and 28 which are hea -sealed onto the plate 1 so as to cover the apertures 22 and 24 (Figure 3 and 6) .
When the contents of the chambers 2 and 3 are to be discharged, the user holds the plate l in the orientation shown in Figure l in both hands, and presses on the centre of the plate 1 with his/her thumbs. This causes the plate to fold about the axis 20 (Figure 4) , thereby also breaking open the chambers 2 and 3 along the corresponding zones of weakness 16 and 18 as indicated in Figure 4.
Each of the compartments 2 and 3 is thus broken in two parts, and the two parts of each compartment are inclined so that the contents thereof are discharged under the influence of gravity.
Although a container for a drug and another agent has been described, it will be appreciated that other substances can be contained. Applying the modification 2 the user holds the longer part of the plate 1 in one hand. Then the user takes the handle 8 in his other hand in away that he takes the handle between thumb and forefinger by locating the thumb in the mould 9. The user holds the plate 1 in an upright position and bends the handle towards the sealing.
This causes the plate to fold about the axis 20 (Figure 5) , thereby also breaking open the chambers 2 and 3 along the corresponding zones of weakness 16 and 18 as indicated in Figure 5.
Then the user discharges the content by turning the opening upside down

Claims

Patent Claims
1. Packaging for two or more substances to be mixed together, the packaging comprising at least a pair of compartments, each for retaining a respective one of the substances, and opening means for opening the compartments to allow the substances to be discharged therefrom, wherein the opening means is so arranged as to be operable to open said compartments substantially simultaneously, and that the opening of either one of the compartments by the opening means cannot be achieved without also opening the other compartments.
2. Packaging according to claim 1 in the form of a two-part system, said packaging comprising a pair of compartments.
3. Packaging according to claim 2, suitable for medication, characterised in that each compartment of said pair of compartments contains a respective drug or one compartment contains a drug and the other an agent to assist in the dissolving of the drug in water.
4. Packaging according to claim 1, characterised in that the opening means is operable to open the compartments at regions on the same side of the packaging so that, with the packaging appropriately orientated, the substances are discharged from the compartments simultaneously.
5. Packaging according to claim 1, characterised in that the opening means comprises a zone of weakness in the packaging, and the packaging is flexible so that appropriate flexing of the packaging causes the latter to be broken open at said zone of weakness.
6. Packaging according to claim 1, characterised in that each compartment has a respective zone of weakness and the packaging comprises a place from which the compartments depend, the plate having at least two apertures through which the substances can be introduced into the compartments thereby to charge the packaging.
7. Packaging according to claim 6, characterised in that, with the packaging charged, the apertures on the plate are sealed by one or more pieces of sheet material.
8. Packaging according to claim 6, characterised in that the plate is foldable about an axis, and the zones of weakness on the compartments run parallel to said axis.
9. Packaging according to claim 6, characterised in that the compartments are elongate so that, when the plate is folded to open the compartments, the latter act as chutes for the substances being discharged.
10. Packaging according to claim 6, characterised in that the compartments are flattened at the end to help locate the user's fingers on the underside of the plate.
11. Packaging according to claim 6, characterised in that a handle is located at one end of the plate.
12. Packaging according to claim 11, characterised in that the handle is designed as a mould or impression in a way that it can be easily hold between thumb and forefinger.
13. Packaging according to claim 2, characterised in that the packaging comprises a polystyrene body having a backing plate 1 from which two cylindrical compartments 2 and 3 with flatted end portions project.
14. Packaging according to claim 13, characterised in that each of the compartments 2 and 3 has a respective line of weakness 16 and 18 extending laterally across the middle of its compartment, and the lines 16 and 18 are aligned with each other.
15. Packaging according to claim 2, characterised in that the packaging comprises a polystyrene body having a backing plate 1 from which two cylindrical compartments 2 and 3 project, said plate 1 comprising a handle 8 located at one end of the backing plate 1.
16. Packaging according to claim 15, characterised in that each of the compartments 2 and 3 has a respective line of weakness 16 and 18 extending laterally across its compartment, whereby the lines 16 and 18 are located outside the middle of the compartments 2 and 3 thus subdividing the longitudinal axis of the compartments 2 and 3 in a short and one longer part in a ratio between 0.5:6 and 2:6, and the lines 16 and 18 are aligned with each other.
17. Packaging according to claim 16, characterised in that the short part of the subdivided longitudinal axis is faced to the handle.
18. Packaging according to claims 13 and 15, characterised in that the face of the plate 1 opposite the compartments 2 and 3 includes apertures 22 and 24 through which the compartments 2 and 3 can be filled.
PCT/EP1997/001197 1996-03-15 1997-03-10 Packaging for two or more substances to be mixed together WO1997034816A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
AU21545/97A AU2154597A (en) 1996-03-15 1997-03-10 Packaging for two or more substances to be mixed together

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB9605548.8A GB9605548D0 (en) 1996-03-15 1996-03-15 Packaging
GB9605548.8 1996-03-15

Publications (1)

Publication Number Publication Date
WO1997034816A1 true WO1997034816A1 (en) 1997-09-25

Family

ID=10790497

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP1997/001197 WO1997034816A1 (en) 1996-03-15 1997-03-10 Packaging for two or more substances to be mixed together

Country Status (8)

Country Link
AU (1) AU2154597A (en)
CO (1) CO4650178A1 (en)
FR (1) FR2746081B3 (en)
GB (1) GB9605548D0 (en)
IT (1) IT1302969B1 (en)
TW (1) TW329416B (en)
UY (1) UY24483A1 (en)
WO (1) WO1997034816A1 (en)

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2000061455A1 (en) * 1999-04-13 2000-10-19 Societe Nouvelle Des Entreprises Guex Packaging for components of a fixing pin obtained by chemical reaction
US6508604B1 (en) 1999-03-19 2003-01-21 The Procter & Gamble Company Article comprising a cell system
US20110259888A1 (en) * 2010-04-26 2011-10-27 Clic Enterprises Inc. Small volume container
JP2012140141A (en) * 2010-12-28 2012-07-26 Mitsukan Co Ltd Fluid material package, food container, and food set in the container
US8910817B2 (en) 2010-04-26 2014-12-16 Clic Enterprises, Inc. Small volume container
US8919594B2 (en) 2007-01-31 2014-12-30 Sands Innovations Pty Ltd Dispensing container
WO2016008508A1 (en) * 2014-07-14 2016-01-21 Nutresia Sa Packaging capsule for at least one portion of food

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10013803A1 (en) * 2000-03-20 2001-10-04 Transcoject Gmbh Hermetically sealed disposable container
DE20021922U1 (en) * 2000-12-23 2001-04-05 Chalupka Juergen Packaging unit for multi-component materials
EP1227047A1 (en) * 2001-01-26 2002-07-31 Snap Pak Limited Easily openable container

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3074540A (en) * 1959-07-31 1963-01-22 American Hospital Supply Corp Package for sterile articles
US3521805A (en) * 1968-09-27 1970-07-28 Anderson Bros Mfg Co Dispensing packet
FR2439725A1 (en) * 1978-10-23 1980-05-23 Sakura Color Prod Corp
EP0271976A2 (en) * 1986-12-18 1988-06-22 Sanford Redmond Asymmetric stress concentrator for a dispenser package
EP0280784A1 (en) * 1987-01-08 1988-09-07 Dispen Pak Japan, Co., Inc. Package

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3074540A (en) * 1959-07-31 1963-01-22 American Hospital Supply Corp Package for sterile articles
US3521805A (en) * 1968-09-27 1970-07-28 Anderson Bros Mfg Co Dispensing packet
FR2439725A1 (en) * 1978-10-23 1980-05-23 Sakura Color Prod Corp
EP0271976A2 (en) * 1986-12-18 1988-06-22 Sanford Redmond Asymmetric stress concentrator for a dispenser package
EP0280784A1 (en) * 1987-01-08 1988-09-07 Dispen Pak Japan, Co., Inc. Package

Cited By (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6508604B1 (en) 1999-03-19 2003-01-21 The Procter & Gamble Company Article comprising a cell system
WO2000061455A1 (en) * 1999-04-13 2000-10-19 Societe Nouvelle Des Entreprises Guex Packaging for components of a fixing pin obtained by chemical reaction
FR2792292A1 (en) * 1999-04-13 2000-10-20 Guex Soc Nouv Entreprises PACKAGING FOR COMPONENTS OF A FIXING PLUG OBTAINED BY CHEMICAL REACTION
US8919594B2 (en) 2007-01-31 2014-12-30 Sands Innovations Pty Ltd Dispensing container
US20110259888A1 (en) * 2010-04-26 2011-10-27 Clic Enterprises Inc. Small volume container
US8910828B2 (en) * 2010-04-26 2014-12-16 Clic Enterprises Inc. Small volume container
US8910817B2 (en) 2010-04-26 2014-12-16 Clic Enterprises, Inc. Small volume container
JP2012140141A (en) * 2010-12-28 2012-07-26 Mitsukan Co Ltd Fluid material package, food container, and food set in the container
WO2016008508A1 (en) * 2014-07-14 2016-01-21 Nutresia Sa Packaging capsule for at least one portion of food

Also Published As

Publication number Publication date
ITMI970563A1 (en) 1998-09-13
AU2154597A (en) 1997-10-10
FR2746081A3 (en) 1997-09-19
TW329416B (en) 1998-04-11
GB9605548D0 (en) 1996-05-15
UY24483A1 (en) 1997-09-12
IT1302969B1 (en) 2000-10-10
FR2746081B3 (en) 1998-02-06
CO4650178A1 (en) 1998-09-03

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