WO2002076436A2 - Modular system of dietary supplement compositions comprising vitamins - Google Patents
Modular system of dietary supplement compositions comprising vitamins Download PDFInfo
- Publication number
- WO2002076436A2 WO2002076436A2 PCT/NL2002/000197 NL0200197W WO02076436A2 WO 2002076436 A2 WO2002076436 A2 WO 2002076436A2 NL 0200197 W NL0200197 W NL 0200197W WO 02076436 A2 WO02076436 A2 WO 02076436A2
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- vitamin
- composition
- water
- dietary supplement
- meg
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 106
- 229940088594 vitamin Drugs 0.000 title claims abstract description 85
- 229930003231 vitamin Natural products 0.000 title claims abstract description 85
- 235000013343 vitamin Nutrition 0.000 title claims abstract description 85
- 239000011782 vitamin Substances 0.000 title claims abstract description 85
- 235000015872 dietary supplement Nutrition 0.000 title claims abstract description 32
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 100
- 150000003722 vitamin derivatives Chemical class 0.000 claims abstract description 56
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 44
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 claims abstract description 26
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 25
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 22
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 22
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 22
- 239000011718 vitamin C Substances 0.000 claims abstract description 22
- 235000013734 beta-carotene Nutrition 0.000 claims abstract description 18
- 239000011648 beta-carotene Substances 0.000 claims abstract description 18
- OENHQHLEOONYIE-JLTXGRSLSA-N β-Carotene Chemical compound CC=1CCCC(C)(C)C=1\C=C\C(\C)=C\C=C\C(\C)=C\C=C\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C OENHQHLEOONYIE-JLTXGRSLSA-N 0.000 claims abstract description 18
- 229910052500 inorganic mineral Inorganic materials 0.000 claims abstract description 14
- 239000011707 mineral Substances 0.000 claims abstract description 14
- 229930003756 Vitamin B7 Natural products 0.000 claims abstract description 11
- 235000011912 vitamin B7 Nutrition 0.000 claims abstract description 11
- 239000011735 vitamin B7 Substances 0.000 claims abstract description 11
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims abstract description 11
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 10
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims abstract description 10
- 235000019175 phylloquinone Nutrition 0.000 claims abstract description 9
- 239000011772 phylloquinone Substances 0.000 claims abstract description 9
- MBWXNTAXLNYFJB-NKFFZRIASA-N phylloquinone Chemical compound C1=CC=C2C(=O)C(C/C=C(C)/CCC[C@H](C)CCC[C@H](C)CCCC(C)C)=C(C)C(=O)C2=C1 MBWXNTAXLNYFJB-NKFFZRIASA-N 0.000 claims abstract description 9
- 229960001898 phytomenadione Drugs 0.000 claims abstract description 9
- 235000009492 vitamin B5 Nutrition 0.000 claims abstract description 7
- 239000011675 vitamin B5 Substances 0.000 claims abstract description 7
- FPIPGXGPPPQFEQ-UHFFFAOYSA-N 13-cis retinol Natural products OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-UHFFFAOYSA-N 0.000 claims abstract description 3
- ABSPRNADVQNDOU-UHFFFAOYSA-N Menaquinone 1 Natural products C1=CC=C2C(=O)C(CC=C(C)C)=C(C)C(=O)C2=C1 ABSPRNADVQNDOU-UHFFFAOYSA-N 0.000 claims abstract description 3
- FPIPGXGPPPQFEQ-BOOMUCAASA-N Vitamin A Natural products OC/C=C(/C)\C=C\C=C(\C)/C=C/C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-BOOMUCAASA-N 0.000 claims abstract description 3
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims abstract description 3
- FPIPGXGPPPQFEQ-OVSJKPMPSA-N all-trans-retinol Chemical compound OC\C=C(/C)\C=C\C=C(/C)\C=C\C1=C(C)CCCC1(C)C FPIPGXGPPPQFEQ-OVSJKPMPSA-N 0.000 claims abstract description 3
- SHUZOJHMOBOZST-UHFFFAOYSA-N phylloquinone Natural products CC(C)CCCCC(C)CCC(C)CCCC(=CCC1=C(C)C(=O)c2ccccc2C1=O)C SHUZOJHMOBOZST-UHFFFAOYSA-N 0.000 claims abstract description 3
- 235000019155 vitamin A Nutrition 0.000 claims abstract description 3
- 239000011719 vitamin A Substances 0.000 claims abstract description 3
- 235000005282 vitamin D3 Nutrition 0.000 claims abstract description 3
- 239000011647 vitamin D3 Substances 0.000 claims abstract description 3
- 229940045997 vitamin a Drugs 0.000 claims abstract description 3
- 229940021056 vitamin d3 Drugs 0.000 claims abstract description 3
- ALYNCZNDIQEVRV-UHFFFAOYSA-N 4-aminobenzoic acid Chemical compound NC1=CC=C(C(O)=O)C=C1 ALYNCZNDIQEVRV-UHFFFAOYSA-N 0.000 claims description 36
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 claims description 19
- 239000011777 magnesium Substances 0.000 claims description 19
- 229910052749 magnesium Inorganic materials 0.000 claims description 19
- GJJVAFUKOBZPCB-UHFFFAOYSA-N 2-methyl-2-(4,8,12-trimethyltrideca-3,7,11-trienyl)-3,4-dihydrochromen-6-ol Chemical compound OC1=CC=C2OC(CCC=C(C)CCC=C(C)CCC=C(C)C)(C)CCC2=C1 GJJVAFUKOBZPCB-UHFFFAOYSA-N 0.000 claims description 10
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 claims description 10
- VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 claims description 10
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 10
- 239000011575 calcium Substances 0.000 claims description 10
- 229910052791 calcium Inorganic materials 0.000 claims description 10
- 229960001231 choline Drugs 0.000 claims description 10
- OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 claims description 10
- 229910052804 chromium Inorganic materials 0.000 claims description 10
- 239000011651 chromium Substances 0.000 claims description 10
- 239000011591 potassium Substances 0.000 claims description 10
- 229910052700 potassium Inorganic materials 0.000 claims description 10
- 229930003802 tocotrienol Natural products 0.000 claims description 10
- 239000011731 tocotrienol Substances 0.000 claims description 10
- 235000019148 tocotrienols Nutrition 0.000 claims description 10
- 229920002770 condensed tannin Polymers 0.000 claims description 9
- AGBQKNBQESQNJD-UHFFFAOYSA-M lipoate Chemical compound [O-]C(=O)CCCCC1CCSS1 AGBQKNBQESQNJD-UHFFFAOYSA-M 0.000 claims description 9
- 235000019136 lipoic acid Nutrition 0.000 claims description 9
- 235000018192 pine bark supplement Nutrition 0.000 claims description 9
- 229940106796 pycnogenol Drugs 0.000 claims description 9
- 229960002663 thioctic acid Drugs 0.000 claims description 9
- SQUHHTBVTRBESD-UHFFFAOYSA-N Hexa-Ac-myo-Inositol Natural products CC(=O)OC1C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C(OC(C)=O)C1OC(C)=O SQUHHTBVTRBESD-UHFFFAOYSA-N 0.000 claims description 8
- ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 claims description 8
- 229940070404 citrus bioflavonoids Drugs 0.000 claims description 8
- 229960000367 inositol Drugs 0.000 claims description 8
- CDAISMWEOUEBRE-GPIVLXJGSA-N inositol Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@H](O)[C@@H]1O CDAISMWEOUEBRE-GPIVLXJGSA-N 0.000 claims description 8
- 229910052750 molybdenum Inorganic materials 0.000 claims description 8
- 239000011733 molybdenum Substances 0.000 claims description 8
- 229910052701 rubidium Inorganic materials 0.000 claims description 8
- IGLNJRXAVVLDKE-UHFFFAOYSA-N rubidium atom Chemical compound [Rb] IGLNJRXAVVLDKE-UHFFFAOYSA-N 0.000 claims description 8
- CDAISMWEOUEBRE-UHFFFAOYSA-N scyllo-inosotol Natural products OC1C(O)C(O)C(O)C(O)C1O CDAISMWEOUEBRE-UHFFFAOYSA-N 0.000 claims description 8
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 7
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 6
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 6
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 6
- 229940110767 coenzyme Q10 Drugs 0.000 claims description 6
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 claims description 6
- 238000002360 preparation method Methods 0.000 claims description 5
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 claims description 4
- 229910052802 copper Inorganic materials 0.000 claims description 4
- 239000010949 copper Substances 0.000 claims description 4
- 229910052720 vanadium Inorganic materials 0.000 claims description 4
- WHXSMMKQMYFTQS-UHFFFAOYSA-N Lithium Chemical compound [Li] WHXSMMKQMYFTQS-UHFFFAOYSA-N 0.000 claims description 3
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 claims description 3
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 claims description 3
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 3
- 150000001875 compounds Chemical class 0.000 claims description 3
- 229960000304 folic acid Drugs 0.000 claims description 3
- 235000019152 folic acid Nutrition 0.000 claims description 3
- 239000011724 folic acid Substances 0.000 claims description 3
- 229910052742 iron Inorganic materials 0.000 claims description 3
- 229910052744 lithium Inorganic materials 0.000 claims description 3
- 229910052711 selenium Inorganic materials 0.000 claims description 3
- 239000011669 selenium Substances 0.000 claims description 3
- 229910052712 strontium Inorganic materials 0.000 claims description 3
- CIOAGBVUUVVLOB-UHFFFAOYSA-N strontium atom Chemical compound [Sr] CIOAGBVUUVVLOB-UHFFFAOYSA-N 0.000 claims description 3
- 229910052725 zinc Inorganic materials 0.000 claims description 3
- 239000011701 zinc Substances 0.000 claims description 3
- RSDQBPGKMDFRHH-MJVIGCOGSA-N (3s,3as,5ar,9bs)-3,5a,9-trimethyl-3a,4,5,7,8,9b-hexahydro-3h-benzo[g][1]benzofuran-2,6-dione Chemical compound O=C([C@]1(C)CC2)CCC(C)=C1[C@@H]1[C@@H]2[C@H](C)C(=O)O1 RSDQBPGKMDFRHH-MJVIGCOGSA-N 0.000 claims description 2
- RSDQBPGKMDFRHH-UHFFFAOYSA-N Taurin Natural products C1CC2(C)C(=O)CCC(C)=C2C2C1C(C)C(=O)O2 RSDQBPGKMDFRHH-UHFFFAOYSA-N 0.000 claims description 2
- 229960004050 aminobenzoic acid Drugs 0.000 claims description 2
- PNDPGZBMCMUPRI-UHFFFAOYSA-N iodine Chemical compound II PNDPGZBMCMUPRI-UHFFFAOYSA-N 0.000 claims description 2
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 claims description 2
- JPFCOVZKLAXXOE-XBNSMERZSA-N (3r)-2-(3,5-dihydroxy-4-methoxyphenyl)-8-[(2r,3r,4r)-3,5,7-trihydroxy-2-(4-hydroxyphenyl)-3,4-dihydro-2h-chromen-4-yl]-3,4-dihydro-2h-chromene-3,5,7-triol Chemical compound C1=C(O)C(OC)=C(O)C=C1C1[C@H](O)CC(C(O)=CC(O)=C2[C@H]3C4=C(O)C=C(O)C=C4O[C@@H]([C@@H]3O)C=3C=CC(O)=CC=3)=C2O1 JPFCOVZKLAXXOE-XBNSMERZSA-N 0.000 claims 1
- 229920001991 Proanthocyanidin Polymers 0.000 claims 1
- 125000000118 dimethyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- GPPXJZIENCGNKB-UHFFFAOYSA-N vanadium Chemical compound [V]#[V] GPPXJZIENCGNKB-UHFFFAOYSA-N 0.000 claims 1
- 239000004615 ingredient Substances 0.000 abstract description 10
- 235000021152 breakfast Nutrition 0.000 abstract description 5
- 230000003797 telogen phase Effects 0.000 abstract description 4
- 238000011084 recovery Methods 0.000 abstract description 2
- 239000013522 chelant Substances 0.000 description 41
- 229940024606 amino acid Drugs 0.000 description 31
- 150000001413 amino acids Chemical class 0.000 description 31
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 description 16
- UEEJHVSXFDXPFK-UHFFFAOYSA-N N-dimethylaminoethanol Chemical compound CN(C)CCO UEEJHVSXFDXPFK-UHFFFAOYSA-N 0.000 description 14
- 229960002887 deanol Drugs 0.000 description 14
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 14
- 229960005069 calcium Drugs 0.000 description 9
- JZRWCGZRTZMZEH-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N JZRWCGZRTZMZEH-UHFFFAOYSA-N 0.000 description 9
- FEWJPZIEWOKRBE-UHFFFAOYSA-M 3-carboxy-2,3-dihydroxypropanoate Chemical compound OC(=O)C(O)C(O)C([O-])=O FEWJPZIEWOKRBE-UHFFFAOYSA-M 0.000 description 8
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 8
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 description 8
- QAQJMLQRFWZOBN-LAUBAEHRSA-N L-ascorbyl-6-palmitate Chemical compound CCCCCCCCCCCCCCCC(=O)OC[C@H](O)[C@H]1OC(=O)C(O)=C1O QAQJMLQRFWZOBN-LAUBAEHRSA-N 0.000 description 8
- 239000011786 L-ascorbyl-6-palmitate Substances 0.000 description 8
- PWHULOQIROXLJO-UHFFFAOYSA-N Manganese Chemical compound [Mn] PWHULOQIROXLJO-UHFFFAOYSA-N 0.000 description 8
- VYGQUTWHTHXGQB-UHFFFAOYSA-N Retinol hexadecanoate Natural products CCCCCCCCCCCCCCCC(=O)OCC=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C VYGQUTWHTHXGQB-UHFFFAOYSA-N 0.000 description 8
- 229930003427 Vitamin E Natural products 0.000 description 8
- 235000010385 ascorbyl palmitate Nutrition 0.000 description 8
- 229940047036 calcium ascorbate Drugs 0.000 description 8
- 235000010376 calcium ascorbate Nutrition 0.000 description 8
- 239000011692 calcium ascorbate Substances 0.000 description 8
- BLORRZQTHNGFTI-ZZMNMWMASA-L calcium-L-ascorbate Chemical compound [Ca+2].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] BLORRZQTHNGFTI-ZZMNMWMASA-L 0.000 description 8
- 238000009472 formulation Methods 0.000 description 8
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 description 8
- 239000011630 iodine Substances 0.000 description 8
- 229910052740 iodine Inorganic materials 0.000 description 8
- 229910052748 manganese Inorganic materials 0.000 description 8
- 239000011572 manganese Substances 0.000 description 8
- 235000010755 mineral Nutrition 0.000 description 8
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 8
- 229960002477 riboflavin Drugs 0.000 description 8
- 235000019192 riboflavin Nutrition 0.000 description 8
- 239000002151 riboflavin Substances 0.000 description 8
- 235000019157 thiamine Nutrition 0.000 description 8
- 239000011721 thiamine Substances 0.000 description 8
- 235000019165 vitamin E Nutrition 0.000 description 8
- 239000011709 vitamin E Substances 0.000 description 8
- 229940046009 vitamin E Drugs 0.000 description 8
- VXVKGIZYLHTHMR-WCCKRBBISA-N (2s)-2-amino-4-methylselanylbutanoic acid;selenium Chemical compound [Se].C[Se]CC[C@H](N)C(O)=O VXVKGIZYLHTHMR-WCCKRBBISA-N 0.000 description 7
- 241000512259 Ascophyllum nodosum Species 0.000 description 7
- PMVSDNDAUGGCCE-TYYBGVCCSA-L Ferrous fumarate Chemical compound [Fe+2].[O-]C(=O)\C=C\C([O-])=O PMVSDNDAUGGCCE-TYYBGVCCSA-L 0.000 description 7
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 description 7
- OENHQHLEOONYIE-UKMVMLAPSA-N all-trans beta-carotene Natural products CC=1CCCC(C)(C)C=1/C=C/C(/C)=C/C=C/C(/C)=C/C=C/C=C(C)C=CC=C(C)C=CC1=C(C)CCCC1(C)C OENHQHLEOONYIE-UKMVMLAPSA-N 0.000 description 7
- UNTBPXHCXVWYOI-UHFFFAOYSA-O azanium;oxido(dioxo)vanadium Chemical compound [NH4+].[O-][V](=O)=O UNTBPXHCXVWYOI-UHFFFAOYSA-O 0.000 description 7
- TUPZEYHYWIEDIH-WAIFQNFQSA-N beta-carotene Natural products CC(=C/C=C/C=C(C)/C=C/C=C(C)/C=C/C1=C(C)CCCC1(C)C)C=CC=C(/C)C=CC2=CCCCC2(C)C TUPZEYHYWIEDIH-WAIFQNFQSA-N 0.000 description 7
- 229960002747 betacarotene Drugs 0.000 description 7
- 229960002685 biotin Drugs 0.000 description 7
- 235000020958 biotin Nutrition 0.000 description 7
- 239000011616 biotin Substances 0.000 description 7
- 229940052810 complex b Drugs 0.000 description 7
- 229960003966 nicotinamide Drugs 0.000 description 7
- 235000005152 nicotinamide Nutrition 0.000 description 7
- 239000011570 nicotinamide Substances 0.000 description 7
- 229960003080 taurine Drugs 0.000 description 7
- KYMBYSLLVAOCFI-UHFFFAOYSA-N thiamine Chemical compound CC1=C(CCO)SCN1CC1=CN=C(C)N=C1N KYMBYSLLVAOCFI-UHFFFAOYSA-N 0.000 description 7
- 229960003495 thiamine Drugs 0.000 description 7
- WGIWBXUNRXCYRA-UHFFFAOYSA-H trizinc;2-hydroxypropane-1,2,3-tricarboxylate Chemical compound [Zn+2].[Zn+2].[Zn+2].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O.[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O WGIWBXUNRXCYRA-UHFFFAOYSA-H 0.000 description 7
- 235000021122 unsaturated fatty acids Nutrition 0.000 description 7
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Classifications
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/16—Inorganic salts, minerals or trace elements
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/30—Dietetic or nutritional methods, e.g. for losing weight
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Definitions
- the present invention relates to a novel dietary supplement composition comprising vitamins, minerals and possible other health-stimulating substances, such as anti- oxidants. More in particular, the invention relates to a dietary supplement composition which is comprised of two or more different independent compositions which are to be taken at different points in time by the user in order to reach an optimum health-effect.
- Vitamins and mineralen are essential building materials for the renewal of healthy cells and white blood corpuscles. They reject toxic substances, control the level of cholesterol, assist in the digestion and provide for optimal functioning of the skin, nerves, muscles and hormones, and strengthen the defence system.
- Anti-oxidants are important substances which offer protection to free radicals. They are produced within the body and their concentration is increased by pollution, sunlight, alcohol and smoke of cigarettes. Too many free radicals may damage the cells in the body and may thus cause various degeneration diseases in the long term.
- Phyto nutrients are natural nutritive substances with active parts from fruit, vegetables, grains, herbs or soya. These nutrients provide optimum protection to free radicals and at the same time they strengthen the defence system to viruses and bacterial infections. Research has revealed that the biorhythm of the human body is distinct in the uptake and removal of vitamins, minerals and anti-oxidants. This knowledge resulted in the development of a formula comprising the proper amounts for an optimum condition and a strong defence system in the body during the day and for rest and recuperation during the night. According to the invention a dietary supplement composition is now provided which both in the matter of the dosage and composition comprises a very complete formula of multivitamins, multiminerals and anti-oxidants, which is very useful for the human health promotion.
- composition A consists essentially of water soluble vitamins
- composition B consists essentially of fat soluble vitamins
- Composition A is an energy-rich composition, which is comprised of water soluble vitamins, preferably supplemented with one or more minerals and other usual health- stimulating substances.
- Composition B is a composition for recovery of the cellen in the rest phase (i.e. during the night), comprised of fat soluble vitamins, preferably supplemented with one or more minerals and other usual ingredients for this purpose.
- composition A is taken in the morning and preferably immerdiately after breakfast and composition B is taken in the evening, i.e. about 9-17 hours after composition A.
- composition B is taken immediately after dinner.
- dietary supplement compositions are known both from literature and the actual practice, among which dietary supplement compositions predominantly consisting of vitamins and minerals and dietary supplement compositions, which are comprised of separate modules which are to be taken at different points in time.
- U.S. Patents Nos. 5,948,443 and 5,976,568 disclose a total modular system of multivitamin- and mineral supplements composed of 7 modules for the promotion of public health and in particular the prevention and treatment of heart- and vascular diseases.
- the module formulations provide nutrients in suitable amounts to the morning and evening meals to obtain maximum absorption which is inter alia caused by administering a dose in the morning and a dose in the evening.
- composition A comprises as vitamins predominantly vitamin C, vitamin B-1 , vitamin B-2, vitamin B-3, vitamin B-5, vitamin B-6, vitamin B-12, vitamin B-15, and vitamin H
- composition B comprises as vitamins predominantly vitamin A, provitamin A, vitamin C, vitamin D3, and vitamin K1. All vitamins are brought in a suitable form for administration.
- Composition A further comprises one or more of the minerals chromium, potassium, copper, magnesium and manganese, in a suitable form for administration.
- Composition A may advantageously further comprise one or more compounds selected from the group consisting of folic acid, p-aminobenzoic acid, choline, inositol, citrus bioflavonoids, pycnogenol, lipoic acid, coenzyme Q10, proanthocyanidine, dimethyl- aminoethanol and nordihydroguarese acid, in a suitable form for administration.
- Composition B further comprises one or more of the minerals borium, calcium, iodine, lithium, magnesium, molybdenum, rubidium, selenium, strontium, vanadium, iron and zinc, in a suitable form for administration.
- Composition B may further advantageously comprise taurin and/or tocotrienol, in a suitable form for administration.
- compositions A and B are not very critical and can be easily determined experimentally by a person skilled in the art, preferably taking into account factors such as the specific needs (or deficiencies) of individuals to whom the vitamin preparations according to the invention are intended, and the age and the weight of these persons.
- Suitable amounts of the components for the compositions A and B and possible further compositions, forming part of the dietary supplement composition according to the present invention are for an effective daily oral dose preferably within the ranges shown in Table 1 below: water Vitamin C (Calcium Ascorbate ) 50 - 1 ,000 mg water Vitamin B-l (Thiamin) 0.7 - 100 mg water Vitamin B-2(Riboflavine) 0.8 - 100 mg water Vitamin B-3(Niacinamide ⁇ Niacine) 9 - 100 mg water Vitamin B-5(Calcium Pantothenate) 5 - 300 mg water Vitamin B-6(Pyridoxal 5-Fosfate) 0.7 - 150 mg water Vitamin B-12(Cyanocobalamine) 1 - 100 meg water Vitamin B-15(Pangaam acid) 10 - 150 mg water Vitamin H (Biotine) 0.15 - 300 meg water Folic acid 50 - 800 meg water Para-aminobenzoic acid (PABA) 15 - 100 mg water Choline (
- the dietary supplement compositions according to the invention may be adapted as far as the composition is concerned to specific target groups (modules).
- modules are for example described in U.S. Patent No. 5,976,568, the content of which is herein incorporated by reference.
- Very suitable, typical basis formulations of a dietary supplement composition according to the invention are for example illustrated in Examples 1 and 2. Other more specific modules are also illustrated in the Examples.
- compositions according to the invention may also be advantageously administered to animals, in particular mammals and especially to pets, such as cats and dogs.
- animals in particular mammals and especially to pets, such as cats and dogs.
- the amounts of the compositions A and B mentioned above usually deviate somewhat from the compositions which are taken by humans, but they can be easily optimized by persons skilled in the art based on the present disclosure and their professional skill and knowledge.
- compositions according to the present invention may be prepared in a known manner for the skilled person.
- compositions A and B may be administered in various pharmaceutical forms which are known per se, the oral administration being preferred.
- the preparations may be adminstered both in solid and liquid form, preferably in unit dose form, which forms and dosages are fully known to persons skilled in the art.
- Suitable solid forms are inter alia capsules, tablets, powders, pastilles and dragees; marikte vloeibare vormen are for example aqueous solutions of the compositions A and B, respectively, in powder form or sirups.
- the present dietary supplement compositions may be advantageously applied for a plurality of indications, such as, for example, the improvement of the total health and condition of human or animal, to early ageing, improvement of the skin, hair and nails, improvement of the stamina, to smoking and/or use of alcohol, to physical and mental stress, for performing well, optimizing the blood quality, to "ups and downs", to periods of fatigue, to absent-mindedness, stimulating muscle-formation, supplementing and formation of building materials, lowering and control of the level of cholesterol, stimulating the healing of sports and other injuries, excessive exposure to sunshine, optimizing the physical energy, and control of body weight.
- indications such as, for example, the improvement of the total health and condition of human or animal, to early ageing, improvement of the skin, hair and nails, improvement of the stamina, to smoking and/or use of alcohol, to physical and mental stress, for performing well, optimizing the blood quality, to "ups and downs", to periods of fatigue, to absent-mindedness, stimulating muscle-formation, supplementing and formation of building materials
- Example 1 A basis dietary supplement composition according to the invention was prepared using the following two compositions:
- composition A Composition A
- a capsule contains the following ingredients:
- Vitamin C (calcium ascorbate) 300 mg
- Vitamin B-2 (Riboflavine) 25 mg Vitamin B-3 (Niacinamide/Niacine) 50 mg
- Vitamin B-5 (Calcium Pantothenate) 50 mg
- Vitamin B-6 (Pyridoxal 5-Phosphate) 25 mg
- Vitamin B-12 (Cyanocobaltamine) 50 meg
- Vitamin B-15 (Pangamic acid) 25 mg Vitamin H (Biotin) 100 meg
- PABA Para-aminobenzoic acid
- Citrus Bioflavonoids 75 mg Pycnogenol 20 mg Lipoic acid 5 mg Coenzyme Q10 30 mg Proanthocyanidine (Extract of grapestones) 10 mg DMAE (Dimethyl aminoethanol) 50 mg NDGA (Nordihydroguareseacid) 50 mg Chromium (GTF) 100 meg Potassium (Amino Chelate) 100 mg Copper (Gluconate) 2 mg
- Composition B A capsule contains the following ingredients:
- Vitamin A (Palmitate) 2.666 ie ⁇ -Carotene (Provitamin A) 15 mg
- Vitamin D3 (Cholecalciferol) 200 ie
- Vitamin E D- -Tocoferol 200 ie Vitamin K1 (Phytonadione) 1 mg
- Vitamin C (Ascorbyl palmitate) 250 mg
- Composition A is a energy-rich composition containing water soluble vitamins supplemented with other ingredients and minerals, which are taken in the morning and 5 preferably immediately after breakfast.
- Composition B is a composition for recuperation of the cells in the rest phase (i.e. during the night), containing fat soluble vitamins, supplemented with other ingredients and mineralen, which are taken in the evening and preferably immediately after dinner.
- composition 1 is preferably taken in the morning, for example at breakfast, whereas composition B is preferably taken 9-17 hours later, and more preferably immediately after dinner.
- Example 2 illustrates a basis formulation, as does Example 1 , whereas Examples 3 to 6 illustrate a module for men, women, children from 1 year of age, adults in the age of
- Vitamin A (Calcium Ascorbate) 300 mg Vitamin A (Palmitate) 2.666 ie water Vitamin B-1 (Thiamine) 25 mg Beta Carotene (Provitamin A) 15 mg water Vitamin B-2 (Riboflavin) 25 mg Vitamin C (Ascorbyl Palmitate) 250 mg water Vitamin B-3 (Niacinamide ⁇ Niacin) 50 mg Vitamin D3 (Cholecalciferol) 200 ie water Vitamin B-5 (Pantothenic Acid) 50 mg Vitamin E (D-Alpha-Tocoferol) 200 ie ⁇ c water Vitamin B-6 (Pyridoxine-5-Phos.) 25 mg Vitamin F ( Unsaturated Fatty Acids) 10 mg water Vitamin B-12 (Cyano Cobaltamine) 25 meg Vitamin Kl (Phytonadione) 1 CD mg
- Vitamin H 150 meg Tocotrienol 20 mg
- Coenzyme Q10 30 mg Selenium (L-Selenomethionine) 200 meg c Procyanidine/Proanthocianidine (OPC) 50 mg Strontium (Citrate) 1 mg
- DMAE Dimethyl aminoethanol
- Vanadum Ammonium Vanadate
- NDGA Nedihydroguaretic Acid
- Iron Feumarate
- GTF Chromium
- Vitamin B (Calcium Ascorbate) 250 mg fat Vitamin A (Palmitate) 5.000 ie water Vitamin B-1 (Thiamine) 25 mg fat Beta Carotene (Provitamin A) 10 mg water Vitamin B-2 (Riboflavin) 25 mg fat Vitamin C (Ascorbyl Palmitate) 250 mg water Vitamin B-3 (Niacinamide ⁇ Niacin) 50 mg fat Vitamin D3 (Cholecalciferol) 200 ie water Vitamin B-5 (Pantothenic Acid) 50 mg fat Vitamin E (D-Alpha-Tocoferol) 200 ie water Vitamin B-6 (Pyridoxine-5-Phos.) 25 mg fat Vitamin F ( Unsaturated Fatty Acids water Vitamin B-12 (Colabamin) 50 meg fat Vitamin Kl (Phytonadione) water Vitamin H (Biotin) 100 meg Taurine 30 mg water Tolic Acid 300 meg Tocotrienol 20 mg water Para-Aminobenzoic Acid (PABA) 50 mg
- Vitamin B-12 Coleabamin
- Vitamin Kl Coleabamin
- Vitamin H Biotin
- DMAE Dimethyl aminoethanol Strontium Strontium (Citrate) 1 mg
- C NDGA Nedihydroguaretic Acid Vanadum (Ammonium vanadate) 300 meg r Chromium (GTF) 100 meg Iron (Fumarate) 15 mg m Potassium (Amino Acid Chelate) 100 mg Zinc (Citrate) 20 mg to Copper (Gluconate) 2 mg
- NDGA Nedihydroguaretic Acid Vanadum (Ammonium Vanadate) 20 meg C r Chromium (GTF) 20 meg Iron (Fumarate) 2,5 mg m Potassium (Amino Acid Chelate) 1 mg Zinc (Citrate) 4 mg
- NDGA Nedihydroguaretic Acid 50 mg Iron (Fumarate) 15 mg C Chromium (GTF) 100 meg Zinc (Citrate) 15 mg m Potassium (Amino Acid Chelate) 150 mg
- Vitamin B (Calcium Ascorbate) 300 mg fat Vitamin A (Palmitate) 6.000 ie water Vitamin B- 1 (Thiamine) 40 mg fat Beta Carotene (Provitamin A) 15 mg water Vitamin B-2 (Riboflavin) 40 mg fat Vitamin C (Ascorbyl Palmitate) 250 mg water Vitamin B-3 (Niacinamide ⁇ Niacin) 80 mg fat Vitamin D3 (Cholecalciferol) 200 ie water Vitamin B-5 (Calcium Pantothenate) 80 mg fat Vitamin E (D-Alpha-Tocoferol) 400 ie water Vitamin B-6 (Pyridoxine-5-Phos.) 40 mg fat Vitamin F ( Unsaturated Fatty Acids) water Vitamin B-12 (Cyano Cobaltmine) 80 meg fat Vitamin Kl (Phytonadione) 1 mg O c water Vitamin B-15 (Calcium Pangamate) 40 mg Taurine 50 mg
- Vitamin H (Biotin) 200 meg Tocotrienol 40 mg O water Folic Acid 400 meg Boron (Citrate) 2 mg
- vitamin preparations according to the invention may be varied in several ways by adding or deleting certain ingredients to or from the compositions
Abstract
The invention pertains to a dietary supplement composition, comprising at least two compositions A and B which are to be taken at different points in time, wherein composition A consists essentially of water soluble vitamins and composition B consists essentially of fat soluble vitamins. Composition A is an energy-rich composition, comprised of water soluble vitamins, supplemented with further ingredients and minerals, which is taken in the morning and preferably immediately after breakfast. Composition B is a composition for recovery of the cells in the rest phase (i.e. during the night), comprised of fat soluble vitamins, supplemended with other ingredients and minerals, which is taken in the evening and preferably immediately after dinner. Composition A comprises as vitamins predominantly vitamin C, vitamin B-1, vitamin B-2, vitamin B-3, vitamin B-5, vitamin B-6, vitamin B-12, vitamin B-15, and vitamin H, and composition B comprises as vitamins predominantly vitamin A, provitamin A, vitamin C, vitamin D3, and vitamin K1.
Description
Dietary supplement composition
The present invention relates to a novel dietary supplement composition comprising vitamins, minerals and possible other health-stimulating substances, such as anti- oxidants. More in particular, the invention relates to a dietary supplement composition which is comprised of two or more different independent compositions which are to be taken at different points in time by the user in order to reach an optimum health-effect.
Vitamins and mineralen are essential building materials for the renewal of healthy cells and white blood corpuscles. They reject toxic substances, control the level of cholesterol, assist in the digestion and provide for optimal functioning of the skin, nerves, muscles and hormones, and strengthen the defence system.
Irregular eating habits, the decline of the quality of the environment and the day-today pressure of work contribute to the harm of the defence system. Since our current nutrition is no longer adequate, it is important to supplement the lack of vitamins and minerals with a dietary supplement composition in order to reach the necessary daily amounts which preferably are also the optimum amounts.
Anti-oxidants are important substances which offer protection to free radicals. They are produced within the body and their concentration is increased by pollution, sunlight, alcohol and smoke of cigarettes. Too many free radicals may damage the cells in the body and may thus cause various degeneration diseases in the long term.
Phyto nutrients are natural nutritive substances with active parts from fruit, vegetables, grains, herbs or soya. These nutrients provide optimum protection to free radicals and at the same time they strengthen the defence system to viruses and bacterial infections. Research has revealed that the biorhythm of the human body is distinct in the uptake and removal of vitamins, minerals and anti-oxidants. This knowledge resulted in the development of a formula comprising the proper amounts for an optimum condition and a strong defence system in the body during the day and for rest and recuperation during the night. According to the invention a dietary supplement composition is now provided which both in the matter of the dosage and composition comprises a very complete formula of multivitamins, multiminerals and anti-oxidants, which is very useful for the human health promotion.
The dietary supplement composition according to the invention is characterised in that it comprises at least two compositions A and B which are to be taken at different points in
time, wherein composition A consists essentially of water soluble vitamins and composition B consists essentially of fat soluble vitamins.
Composition A is an energy-rich composition, which is comprised of water soluble vitamins, preferably supplemented with one or more minerals and other usual health- stimulating substances. Composition B is a composition for recovery of the cellen in the rest phase (i.e. during the night), comprised of fat soluble vitamins, preferably supplemented with one or more minerals and other usual ingredients for this purpose.
Composition A is taken in the morning and preferably immerdiately after breakfast and composition B is taken in the evening, i.e. about 9-17 hours after composition A. Preferably, composition B is taken immediately after dinner.
Many varieties of dietary supplement compositions are known both from literature and the actual practice, among which dietary supplement compositions predominantly consisting of vitamins and minerals and dietary supplement compositions, which are comprised of separate modules which are to be taken at different points in time. For example, U.S. Patents Nos. 5,948,443 and 5,976,568 disclose a total modular system of multivitamin- and mineral supplements composed of 7 modules for the promotion of public health and in particular the prevention and treatment of heart- and vascular diseases. The module formulations provide nutrients in suitable amounts to the morning and evening meals to obtain maximum absorption which is inter alia caused by administering a dose in the morning and a dose in the evening.
However, none of the references describes or suggests a dietary supplement composition according to the invention where the composition provides a strict separation between Composition A with the water soluble vitamins in the morning (at or around breakfast) and Composition B with the fat soluble vitamins in the evening (at or around dinner). As far as the inventor is aware, such strict separation is not made in the dietary supplement compositions which are known in actual practice. According to the aforementioned U.S. Patents a "module" is defined as a separate and distinct combination of vitamin-mineral and other health promoting compounds which are directed to specific target populations. In the present invention the same definition of "module" is used as the occasion arises. According to the invention composition A comprises as vitamins predominantly vitamin C, vitamin B-1 , vitamin B-2, vitamin B-3, vitamin B-5, vitamin B-6, vitamin B-12, vitamin B-15, and vitamin H, and composition B comprises as vitamins predominantly vitamin A, provitamin A, vitamin C, vitamin D3, and vitamin K1. All vitamins are brought in a suitable form for administration.
Preferably, Composition A further comprises one or more of the minerals chromium, potassium, copper, magnesium and manganese, in a suitable form for administration. Composition A may advantageously further comprise one or more compounds selected from the group consisting of folic acid, p-aminobenzoic acid, choline, inositol, citrus bioflavonoids, pycnogenol, lipoic acid, coenzyme Q10, proanthocyanidine, dimethyl- aminoethanol and nordihydroguarese acid, in a suitable form for administration.
Preferably, Composition B further comprises one or more of the minerals borium, calcium, iodine, lithium, magnesium, molybdenum, rubidium, selenium, strontium, vanadium, iron and zinc, in a suitable form for administration. Composition B may further advantageously comprise taurin and/or tocotrienol, in a suitable form for administration.
The amounts of the various ingredients in the compositions A and B are not very critical and can be easily determined experimentally by a person skilled in the art, preferably taking into account factors such as the specific needs (or deficiencies) of individuals to whom the vitamin preparations according to the invention are intended, and the age and the weight of these persons.
Suitable amounts of the components for the compositions A and B and possible further compositions, forming part of the dietary supplement composition according to the present invention, are for an effective daily oral dose preferably within the ranges shown in Table 1 below: water Vitamin C (Calcium Ascorbate ) 50 - 1 ,000 mg water Vitamin B-l (Thiamin) 0.7 - 100 mg water Vitamin B-2(Riboflavine) 0.8 - 100 mg water Vitamin B-3(Niacinamide\Niacine) 9 - 100 mg water Vitamin B-5(Calcium Pantothenate) 5 - 300 mg water Vitamin B-6(Pyridoxal 5-Fosfate) 0.7 - 150 mg water Vitamin B-12(Cyanocobalamine) 1 - 100 meg water Vitamin B-15(Pangaam acid) 10 - 150 mg water Vitamin H (Biotine) 0.15 - 300 meg water Folic acid 50 - 800 meg water Para-aminobenzoic acid (PABA) 15 - 100 mg water Choline (Bitartrate) 15 - 150 mg water Inositol 10 - 100 mg water Citrus Bioflavonoids 12 - 200 mg water Pycnogenol 10 - 150 mg
Lipoic acid 0 - 100 mg
Coenzyme Q10 5 - 200 mg
Procyanidine/Proanthocianidine (OPC) 20 - 100 mg
DMAE (Dimethyl aminoethanol) 0 - 500 mg
NDGA (Nordihydroguarese acid) 0 - 500 mg
Chromium (GTF) 10 - 300 meg
Potassium 30 - 600 mg
Copper 0 -5 mg
Magnesium 50 - 500 mg
Manganese 1-12 mg fat Vitamin A (Palmitate) 250 - 15,000 ie fat Beta Caroteen (Provitamin A) 3 - 40 mg fat Vitamin C (Ascorbyl palmitate) 50 - 1 ,000 mg fat Vitamin D3 (Cholecalciferol) 0.5 - 400 ie fat Vitamin E (D-Alpha-Tocoferol) 3 - 1500 ie fat Vitamin F (Unsaturated fatty acids) 0 - 150 mg fat Vitamin K1 (Phytonadione) 0 - 2 mg
Ta urine 10 - 750 mg
Tocotrienol 5 - 150 mg
Borium 0 - 10 mg
Calcium 80 -1 ,500 mg
Iodine 15 - 500 meg
Lithium 0 - 1 ,000 meg
Magnesium 50 - 500 mg
Molybdeen 30 - 500 meg
Rubidinum 0 - 600 meg
Selenium 20 - 1 ,000 meg
Strontium 0 - 10 mg
Vanadium 0 - 500 meg
Iron 1 - 30 mg
Zinc 5 - 30 mg
The dietary supplement compositions according to the invention may be adapted as far as the composition is concerned to specific target groups (modules). Such modules are for example described in U.S. Patent No. 5,976,568, the content of which is herein incorporated by reference. Very suitable, typical basis formulations of a dietary supplement composition according to the invention are for example illustrated in Examples 1 and 2. Other more specific modules are also illustrated in the Examples.
The dietary supplement compositions according to the invention may also be advantageously administered to animals, in particular mammals and especially to pets, such as cats and dogs. The amounts of the compositions A and B mentioned above usually deviate somewhat from the compositions which are taken by humans, but they can be easily optimized by persons skilled in the art based on the present disclosure and their professional skill and knowledge.
The dietary supplement compositions according to the present invention may be prepared in a known manner for the skilled person. The preparations, i.e. Compositions A and
B, respectively, may be administered in various pharmaceutical forms which are known per se, the oral administration being preferred. The preparations may be adminstered both in solid and liquid form, preferably in unit dose form, which forms and dosages are fully known to
persons skilled in the art. Suitable solid forms are inter alia capsules, tablets, powders, pastilles and dragees; geschikte vloeibare vormen are for example aqueous solutions of the compositions A and B, respectively, in powder form or sirups.
The present dietary supplement compositions may be advantageously applied for a plurality of indications, such as, for example, the improvement of the total health and condition of human or animal, to early ageing, improvement of the skin, hair and nails, improvement of the stamina, to smoking and/or use of alcohol, to physical and mental stress, for performing well, optimizing the blood quality, to "ups and downs", to periods of fatigue, to absent-mindedness, stimulating muscle-formation, supplementing and formation of building materials, lowering and control of the level of cholesterol, stimulating the healing of sports and other injuries, excessive exposure to sunshine, optimizing the physical energy, and control of body weight.
De invention is illustrated below by the following Examples which, however, are not to be construed as restricting the invention in any respect.
Example 1 A basis dietary supplement composition according to the invention was prepared using the following two compositions:
Composition A
A capsule contains the following ingredients:
Vitamin C (calcium ascorbate) 300 mg
Vitamin B-1 (Thiamine) 25 mg
Vitamin B-2 (Riboflavine) 25 mg Vitamin B-3 (Niacinamide/Niacine) 50 mg
Vitamin B-5 (Calcium Pantothenate) 50 mg
Vitamin B-6 (Pyridoxal 5-Phosphate) 25 mg
Vitamin B-12 (Cyanocobaltamine) 50 meg
Vitamin B-15 (Pangamic acid) 25 mg Vitamin H (Biotin) 100 meg
Folic acid 400 meg
Para-aminobenzoic acid (PABA) 50 mg
Choline (Bitartrate) 50 mg
Inositol 50 mg
fi
Citrus Bioflavonoids 75 mg Pycnogenol 20 mg Lipoic acid 5 mg Coenzyme Q10 30 mg Proanthocyanidine (Extract of grapestones) 10 mg DMAE (Dimethyl aminoethanol) 50 mg NDGA (Nordihydroguareseacid) 50 mg Chromium (GTF) 100 meg Potassium (Amino Chelate) 100 mg Copper (Gluconate) 2 mg
Magnesium (Amino Chelate) 150 mg Manganese (Amino Chelate) 5 mg
Composition B A capsule contains the following ingredients:
Vitamin A (Palmitate) 2.666 ie β-Carotene (Provitamin A) 15 mg
Vitamin D3 (Cholecalciferol) 200 ie
Vitamin E (D- -Tocoferol) 200 ie Vitamin K1 (Phytonadione) 1 mg
Vitamin C (Ascorbyl palmitate) 250 mg
Taurine 250 mg
Tocotrienol 20 mg
Borium (Citrate) 1 mg Calcium (Amino Chelate) 250 mg
Iodine (Kelp) 100 meg
Lithium (Citrate) 500 meg
Magnesium (Amino Chelate) 150 meg
Molybdenum (Molybdate) 200 meg Rubidium (Amino Chelate) 500 meg
Selenium (L-selenomethionine) 200 meg
Strontium (Citrate) 1 mg
Vanadium (Ammonium vanadate) 500 meg
Iron (Fumarate) 10 mg
Zinc (Citrate) 15 mg
Composition A is a energy-rich composition containing water soluble vitamins supplemented with other ingredients and minerals, which are taken in the morning and 5 preferably immediately after breakfast. Composition B is a composition for recuperation of the cells in the rest phase (i.e. during the night), containing fat soluble vitamins, supplemented with other ingredients and mineralen, which are taken in the evening and preferably immediately after dinner.
10 Examples 2 to 7
These Examples illustrate in the following Table some specific modules of dietary supplement compositions according to the present invention, always consisting of an energy rich Composition or Complex A containing water soluble vitamins and other ingredients, and a Composition or Complex B for the recuperation of the cells in the rest phase, containing fat
15 soluble vitamins. Composition 1 is preferably taken in the morning, for example at breakfast, whereas composition B is preferably taken 9-17 hours later, and more preferably immediately after dinner.
Example 2 illustrates a basis formulation, as does Example 1 , whereas Examples 3 to 6 illustrate a module for men, women, children from 1 year of age, adults in the age of
20 50+, and a module for sportsmen, respectively.
Example 2
Basis formulation
Complex A AM Complex B PM water Vitamin C (Calcium Ascorbate) 300 mg Vitamin A (Palmitate) 2.666 ie water Vitamin B-1 (Thiamine) 25 mg Beta Carotene (Provitamin A) 15 mg water Vitamin B-2 (Riboflavin) 25 mg Vitamin C (Ascorbyl Palmitate) 250 mg water Vitamin B-3 (Niacinamide\Niacin) 50 mg Vitamin D3 (Cholecalciferol) 200 ie water Vitamin B-5 (Pantothenic Acid) 50 mg Vitamin E (D-Alpha-Tocoferol) 200 ie ω c water Vitamin B-6 (Pyridoxine-5-Phos.) 25 mg Vitamin F ( Unsaturated Fatty Acids) 10 mg water Vitamin B-12 (Cyano Cobaltamine) 25 meg Vitamin Kl (Phytonadione) 1 CD mg
(Λ water Vitamin B-15 (Pangamic Acid) 25 mg Taurine 25 mg
H water Vitamin H (Biotin) 150 meg Tocotrienol 20 mg
H water Folic Acid 400 meg Boron (Citrate) 1 mg
C water Para-Aminobenzoic Acid (PABA) 50 mg Calcium (Amino Acid Chelate) 250 mg r Hπ water Choline (Bitartrate) 50 mg Iodine (Kelp) 100 meg
Coenzyme Q10 30 mg Selenium (L-Selenomethionine) 200 meg c Procyanidine/Proanthocianidine (OPC) 50 mg Strontium (Citrate) 1 mg
DMAE (Dimethyl aminoethanol) 50 mg Vanadum (Ammonium Vanadate) 500 meg m NDGA (Nordihydroguaretic Acid 50 mg Iron (Fumarate) 10 mg σ> Chromium (GTF) 100 meg Zinc (Citrate) 15 mg
Potassium (Amino Acid Chelate) 100 mg
Copper (Gluconate) 2 mg
Magnesium (Amino Λcid Chelate) 150 mg
Manganese (Amino Acid Chelate) 5 mg
Exampli ε 3
Men's 1 formulation
Complex A AM Complex B PM water Vitamin C (Calcium Ascorbate) 250 mg fat Vitamin A (Palmitate) 5.000 ie water Vitamin B-1 (Thiamine) 25 mg fat Beta Carotene (Provitamin A) 10 mg water Vitamin B-2 (Riboflavin) 25 mg fat Vitamin C (Ascorbyl Palmitate) 250 mg water Vitamin B-3 (Niacinamide\Niacin) 50 mg fat Vitamin D3 (Cholecalciferol) 200 ie water Vitamin B-5 (Pantothenic Acid) 50 mg fat Vitamin E (D-Alpha-Tocoferol) 200 ie water Vitamin B-6 (Pyridoxine-5-Phos.) 25 mg fat Vitamin F ( Unsaturated Fatty Acids water Vitamin B-12 (Colabamin) 50 meg fat Vitamin Kl (Phytonadione) water Vitamin H (Biotin) 100 meg Taurine 30 mg water Tolic Acid 300 meg Tocotrienol 20 mg water Para-Aminobenzoic Acid (PABA) 50 mg Boron (Citrate) 1 mg water Choline (Bitartrate) 50 mg Calcium (Amino Acid Chelate) 50 mg water Inositol 50 mg Iodine (Kelp) 100 meg
water Citrus Bioflavonoids 50 mg Lithium (Citrate) 500 meg to water Pycnogenol 20 mg Magnesium (Amino Acid Chelate) 150 mg T Lipoic Acid 5 mg Molybdenum (Molybdate) 200 meg m 40 mg m Coenzyme Q 10 Rubidium (Amino Acid Chelate) 500 meg
Procyanidine/Proanthocianidine (OPC) Selenium (L-Selenomethionine) 200 meg
DMAE (Dimethylaminoethanol) Strontium (Citrate) 1 mg
50 NDGA (Nordihydroguaretic Acid Vanadum (Ammonium Vanadate) 500 meg
C r Chromium (GTF) 100 meg Iron (Fumarate) 10 mg m Potassium (Amino Acid Chelate) 100 mg Zinc (Citrate) 15 mg
Copper (Gluconate) 2 mg
9)
Magnesium (Amino Acid Chelate) 150 mg
Manganese (Amino Acid Chelate) 5 mg
Example 4
Women' 's formulation
Complex A AM Complex B PM water Vitamin C (Calcium Ascorbate) 200 mg fat Vitamin A (Palmitate) 4.000 ie water Vitamin B-1 (Thiamine) 25 mg fat Beta Carotene (Provitamin A) 10 mg water Vitamin B-2 (Riboflavin) 25 mg fat Vitamin C (Ascorbyl Palmitate) 200 mg water Vitamin B-3 (Niacinamide\Niacin) 25 mg fat Vitamin D3 (Cholecalciferol) 400 ie water Vitamin B-5 (Pantothenic Acid) 50 mg fat Vitamin E (D-Alpha-Tocoferol) 200 ie water Vitamin B-6 (Pyridoxine-5-Phos.) 25 mg fat Vitamin F ( Unsaturated Fatty Acids)
CO water Vitamin B-12 (Colabamin) 25 meg fat Vitamin Kl (Phytonadione) c water Vitamin H (Biotin) 100 meg Taurine 50 mg
00 CO water Folic Acid 500 meg Tocotrienol 20 mg
H water Para-Aminobenzoic Acid (PABA) 50 mg Boron (Citrate) 1 mg
H water Choline (Bitartrate) 40 mg Calcium (Amino Acid Chelate) 500 mg
C water Inositol 50 mg Iodine (Kelp) 125 meg H m water Citrus Bioflavonoids 50 mg Lithium (Citrate) 500 meg
CO water Pycnogenol 20 mg Magnesium (Amino Acid Chelate) 200 mg
I Lipoic Acid Molybdenum (Molybdate) 300 meg m m Coenzyme Q10 30 mg Rubidium (Amino Acid Chelate) 500 meg
H Procyanidine/Proanthocianidine (OPC) Selenium (L-Selenomethionine) 200 meg
DMAE (Dimethyl aminoethanol) Strontium (Citrate) 1 mg C NDGA (Nordihydroguaretic Acid Vanadum (Ammonium vanadate) 300 meg r Chromium (GTF) 100 meg Iron (Fumarate) 15 mg m Potassium (Amino Acid Chelate) 100 mg Zinc (Citrate) 20 mg to Copper (Gluconate) 2 mg
Magnesium (Amino Acid Chelate) 200 mg
Manganese (Amino Acid Chelate) 5 mg
Exampli e 5
Children.s over 1 year formulation Complex A AM Complex B PM water Vitamin C (Calcium Ascorbate) 75 mg fat Vitamin A (Palmitate) 1.250 ie water Vitamin B-1 (Thiamine) 5 mg fat Beta Carotene (Provitamin A) 5 mg water Vitamin B-2 (Riboflavin) 5 mg fat Vitamin C (Ascorbyl Palmitate) 75 mg water Vitamin B-3 (NiacinamideVNiacin) 10 mg fat Vitamin D3 (Cholecalciferol) 200 ie water Vitamin B-5 (Calcium Pantothenate) 10 mg fat Vitamin E (D-Alpha-Tocoferol) 18 ie water Vitamin B-6 (Pyridoxine-5-Phosphate) 5 mg fat Vitamin F ( Unsaturated Fatty Acids water Vitamin B- 12 (Cyano Cobaltamin) 5 meg fat Vitamin Kl (Phytonadione) 1 mg water Vitamin H (Biotin) 100 meg Taurine water Folic Acid 200 meg Tocotrienol water Para-Aminobenzoic Acid (PABA) 1 mg Boron (Citrate) 300 meg water Choline (Bitartrate) 10 mg Calcium (Amino Acid Chelate) 50 mg water Inositol 10 mg Iodine (Kelp) 50 meg water Citrus Bioflavonoids 10 mg Lithium (Citrate)
water Pycnogenol Magnesium (Amino Acid Chelate) 10 mg O x Lipoic Acid Molybdenum (Molybdate) 20 meg m Coenzyme Q10 Rubidium (Amino Acid Chelate) m
H Procyanidine/Proanthocianidine (OPC) Selenium (L-Selenomethionine) 50 meg
DMAE (Dimethyl Aminoethanol) Strontium (Citrate) 0,5 mg
NDGA (Nordihydroguaretic Acid Vanadum (Ammonium Vanadate) 20 meg C r Chromium (GTF) 20 meg Iron (Fumarate) 2,5 mg m Potassium (Amino Acid Chelate) 1 mg Zinc (Citrate) 4 mg
10 Copper (Gluconate) 0.5 mg σ> Magnesium (Amino Acid Chelate) 10 mg
Manganese (Arnino Acid Chelate) 1 mg
Example 6
Over 50 years formulation
Complex A AM Complex B PM water Vitamin C (Calcium Ascorbate) 300 mg fat Vitamin A (Palmitate) 4.000 ie water Vitamin B-1 (Thiamine) 25 mg fat Beta Carotene (Provitamin A) 15 mg water Vitamin B-2 (Riboflavin) 25 mg fat Vitamin C (Ascorbyl Palmitate) 200 mg water Vitamin B-3 (Niacinamide\Niacin) 70 mg fat Vitamin D3 (Cholecalciferol) 200 ie water Vitamin B-5 (Pantothenic Acid) 100 mg fat Vitamin E (D-Alpha-Tocoferol) 400 ie water Vitamin B-6 (Pyridoxine-5-Phos.) 25 mg fat Vitamin F (Unsaturated Fatty Acids) 15 mg water Vitamin B-12 (Colabamin) 50 meg fat Vitamin Kl (Phytonadione) 1 mg water Vitamin B-15 (Calcium Pangamate) 30 mg Taurine 30 mg
CO c water Vitamin H (Biotin) 100 meg Tocotrienol 20 mg
03 water Folic Acid 400 meg Boron (Citrate) 1 mg CO water Para-Aminobenzoic Acid (PABA) 50 mg Calcium (Amino Acid Chelate) 500 mg H water Choline (Bitartrate) 50 mg Iodine (Kelp) 150 meg
H C water Inositol 50 mg Lithium (Citrate) 500 meg H water Citrus Bioflavonoids 50 mg Magnesium (Amino Acid Chelate) 150 mg
Pycnogenol 20 mg Molybdenum (Molybdate) 200 meg O z Lipoic Acid 5 mg Rubidium (Amino Chelate) 500 meg m Coenzyme Q 10 30 mg Selenium (L-Selenomethionine) 200 meg
Procyanidine/Proanthocianidine (OPC) 40 mg Strontium (Citrate) 1 mg
H DMAE (Dimethylaminoethanol) 50 mg Vanadum (Ammoniumvanadate) 500 meg
NDGA (Nordihydroguaretic Acid 50 mg Iron (Fumarate) 15 mg C Chromium (GTF) 100 meg Zinc (Citrate) 15 mg m Potassium (Amino Acid Chelate) 150 mg
10 Copper (Amino Acid Chelate) 2 mg
Magnesium (Amino Acid Chelate) 150 mg
Manganese (Λmino Acid Chelate) 7 mg
Soyagerm complex 300 mg
Phosphorus (Calcium Phosphate) 100 mg
Example 7
Sports formulalion
Complex A AM Complex B PM water Vitamin C (Calcium Ascorbate) 300 mg fat Vitamin A (Palmitate) 6.000 ie water Vitamin B- 1 (Thiamine) 40 mg fat Beta Carotene (Provitamin A) 15 mg water Vitamin B-2 (Riboflavin) 40 mg fat Vitamin C (Ascorbyl Palmitate) 250 mg water Vitamin B-3 (Niacinamide\Niacin) 80 mg fat Vitamin D3 (Cholecalciferol) 200 ie water Vitamin B-5 (Calcium Pantothenate) 80 mg fat Vitamin E (D-Alpha-Tocoferol) 400 ie water Vitamin B-6 (Pyridoxine-5-Phos.) 40 mg fat Vitamin F ( Unsaturated Fatty Acids) water Vitamin B-12 (Cyano Cobaltmine) 80 meg fat Vitamin Kl (Phytonadione) 1 mg O c water Vitamin B-15 (Calcium Pangamate) 40 mg Taurine 50 mg
03 water Vitamin H (Biotin) 200 meg Tocotrienol 40 mg O water Folic Acid 400 meg Boron (Citrate) 2 mg
H water Para-Aminobenzoic Acid (PABA) 50 mg Calcium (Amino Acid Chelate) 250 mg
H water Choline (Bitartrate) 100 mg Iodine (Kelp) 150 meg
C H water Inositol 100 mg Lithium (Citrate) 500 meg m water Citrus Bioflavonoids 100 mg Magnesium (Amino Acid Chelate) 150 mg
CO water Pycnogenol 40 mg Molybdenum (Molybdate) 100 meg x m Lipoic Acid 10 mg Rubidium (Amino Acid Chelate) 500 meg m Coenzyme Q10 20 mg Selenium (L-Selenomethionine) 200 meg
H Procyanidine/Proanthocianidine (OPC) 75 mg Strontium (Citrate) 2 mg
7J DMAE (Dimethylaminoethanol) Vanadum (Ammonium Vanadate) 100 meg
C NDGA (Nordihydroguaretic Acid Iron (Fumarate) 15 mg r m Chromium (GTF) 100 meg Zinc (Citrate) 15 mg
Potassium (Amino Acid Chelate) 150 mg Coenzyme Q10 20 mg
10 Copper (Gluconate) 2 mg L-Glutamine 25 mg
Magnesium (Amino Acid Chelate) 150 mg L-Cysteine 50 mg
Manganese (Amino Acid Chelate) 10 mg L-Leucine 100 mg
L-Isoleucine 100 mg
L-Valine 100 mg
L- Camitine 50 mg
L- Methionine 50 mg
It will be understood, that the vitamin preparations according to the invention may be varied in several ways by adding or deleting certain ingredients to or from the compositions
A and B, or by modifying amounts as illustrated in the Examples. All such variants are meant to be encompassed by the scope of the invention, which is determined by the claims that follow.
Claims
1. Dietary supplement composition, said dietary supplement composition comprising at least two compositions A and B which are to be taken at different points in time, wherein composition A consists essentially of water soluble vitamins and composition B consists essentially of fat soluble vitamins.
2. Dietary supplement composition according to claim 1 , wherein composition A in is taken in the morning and composition B is taken 9-17 hours after composition A.
3. Dietary supplement composition according to claim 1 or 2, wherein composition A comprises as vitamins predominantly vitamin C, vitamin B-1 , vitamin B-2, vitamin B-3, vitamin B-5, vitamin B-6, vitamin B-12, vitamin B-15, and vitamin H, and composition B comprises as vitamins predominantly vitamin A, provitamin A, vitamin C, vitamin D3, and vitamin K1.
4. Dietary supplement composition according to any one of claims 1 to 3, wherein composition A further comprises one or more of the minerals chromium, potassium, copper, magnesium, and manganese, in a suitable form for administration.
5. Dietary supplement composition according to any one of claims 1 to 3, wherein composition B further comprises one or more of the minerals borium, calcium, iodine, lithium, magnesium, molybdenum, rubidium, selenium, strontium, vanadium, iron, and zinc, in a suitable form for administration.
6. Dietary supplement composition according to any one of claims 1 to 4, wherein composition A further comprises one or more compounds selected from the group consisting of folic acid, p-aminobenzoic acid, choline, inositol, citrus bioflavonoids, pycnogenol, lipoic acid, coenzyme Q10, proanthocyanidin, dimethyl a inoethanol, and nordihydroguareseacid, in a suitable form for administration.
7. Dietary supplement composition according to any one of claims 1 to 3 and 5, wherein composition B further comprises taurin and/or tocotrienol, in a suitable form for administration.
8. Dietary supplement composition according to any one of the preceding claims, wherein this preparation is comprised of compositions A and B, essentially as described in Examples 1 to 7, respectively.
9. Composition A of the dietary supplement composition as defined in any one of the preceding claims.
10. Composition B of the dietary supplement composition as defined in any one of the preceding claims.
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP20020707347 EP1469746A2 (en) | 2001-03-27 | 2002-03-27 | Modular system of dietary supplement compositions comprising vitamins |
| AU2002241408A AU2002241408A1 (en) | 2001-03-27 | 2002-03-27 | Modular system of dietary supplement compositions comprising vitamins |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| NL1017707 | 2001-03-27 | ||
| NL1017707A NL1017707C2 (en) | 2001-03-27 | 2001-03-27 | Vitamin preparation. |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| WO2002076436A2 true WO2002076436A2 (en) | 2002-10-03 |
| WO2002076436A3 WO2002076436A3 (en) | 2003-03-13 |
Family
ID=19773142
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| PCT/NL2002/000197 WO2002076436A2 (en) | 2001-03-27 | 2002-03-27 | Modular system of dietary supplement compositions comprising vitamins |
Country Status (4)
| Country | Link |
|---|---|
| EP (1) | EP1469746A2 (en) |
| AU (1) | AU2002241408A1 (en) |
| NL (1) | NL1017707C2 (en) |
| WO (1) | WO2002076436A2 (en) |
Cited By (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2003079819A1 (en) * | 2002-03-27 | 2003-10-02 | Anglo French Drugs And Industries Ltd. | Dietary supplement composition and a process of manufacturing said composition |
| WO2004017766A1 (en) * | 2002-08-23 | 2004-03-04 | Dsm Ip Assets B.V. | Novel nutraceutical compositions comprising biotin |
| WO2004041257A2 (en) * | 2002-11-07 | 2004-05-21 | Dsm Ip Assets B.V. | Novel nutraceutical compositions comprising epigallocatechin gallate |
| FR2859104A1 (en) * | 2003-08-29 | 2005-03-04 | Saint Laurent Parfums | MOLECULES WITH ANTI-ADIPOGENIC ACTIVITY ON HUMAN ADIPOCYTE CELLS |
| EP1541041A1 (en) * | 2003-12-10 | 2005-06-15 | Synergia Holding | Pharmaceutical and/or dietary compositions against stress |
| EP1656148A1 (en) * | 2003-08-21 | 2006-05-17 | Duchesnay Inc. | Micronutrient supplement |
| US7354914B2 (en) | 2000-06-01 | 2008-04-08 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of Aβ protein production |
| WO2008064297A1 (en) * | 2006-11-21 | 2008-05-29 | The Coca-Cola Company | Nutritional beverage for optimal bone health |
| EP2135621A1 (en) * | 2008-06-18 | 2009-12-23 | Roberto Fasani | Combined formulations for the treatment of the male infertility |
| US20110177010A1 (en) * | 2007-11-27 | 2011-07-21 | Nutri Team Gmbh | Vitamin preparation |
| CN102319263A (en) * | 2011-08-17 | 2012-01-18 | 江门市新会区光华生物科技有限公司 | Film coated tablets containing a plurality of vitamins and mineral matters, and its preparation process |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
| US8183227B1 (en) | 2011-07-07 | 2012-05-22 | Chemo S. A. France | Compositions, kits and methods for nutrition supplementation |
| AT510810A1 (en) * | 2010-12-09 | 2012-06-15 | Gonadosan Gmbh | COMBINATION PROCEDURE FOR IMPROVING FEMALE FERTILITY |
| JP2013056867A (en) * | 2011-09-09 | 2013-03-28 | Pias Arise Kk | Kit for adjusting circadian rhythm and method for adjusting circadian rhythm |
| WO2014155370A1 (en) * | 2013-03-29 | 2014-10-02 | Omega Pharma Innovation & Development Nv | Kit with multiple nutritional supplements and a method for assembling thereof |
| US20150164825A1 (en) * | 2008-06-03 | 2015-06-18 | John Ray Biffin | Method for increasing bone density and/or reducing any osteochondral defects in an animal and a composition including vitamin k |
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| JPS59152327A (en) * | 1983-02-16 | 1984-08-31 | Otsuka Pharmaceut Co Ltd | Stabilized vitamin preparation |
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2001
- 2001-03-27 NL NL1017707A patent/NL1017707C2/en not_active IP Right Cessation
-
2002
- 2002-03-27 AU AU2002241408A patent/AU2002241408A1/en not_active Abandoned
- 2002-03-27 EP EP20020707347 patent/EP1469746A2/en not_active Withdrawn
- 2002-03-27 WO PCT/NL2002/000197 patent/WO2002076436A2/en not_active Application Discontinuation
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| WO2000030477A1 (en) * | 1998-11-19 | 2000-06-02 | Norbert Fuchs | Beverage for increasing the body's capacity to break down alcohol |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7354914B2 (en) | 2000-06-01 | 2008-04-08 | Bristol-Myers Squibb Pharma Company | Lactams substituted by cyclic succinates as inhibitors of Aβ protein production |
| WO2003079819A1 (en) * | 2002-03-27 | 2003-10-02 | Anglo French Drugs And Industries Ltd. | Dietary supplement composition and a process of manufacturing said composition |
| WO2004017766A1 (en) * | 2002-08-23 | 2004-03-04 | Dsm Ip Assets B.V. | Novel nutraceutical compositions comprising biotin |
| WO2004041257A2 (en) * | 2002-11-07 | 2004-05-21 | Dsm Ip Assets B.V. | Novel nutraceutical compositions comprising epigallocatechin gallate |
| WO2004041257A3 (en) * | 2002-11-07 | 2004-08-05 | Dsm Ip Assets Bv | Novel nutraceutical compositions comprising epigallocatechin gallate |
| JP2007533607A (en) * | 2003-08-21 | 2007-11-22 | デュシェネ インク | Micronutrient supplements |
| EP1656148A1 (en) * | 2003-08-21 | 2006-05-17 | Duchesnay Inc. | Micronutrient supplement |
| EP1656148A4 (en) * | 2003-08-21 | 2011-07-20 | Duchesnay Inc | Micronutrient supplement |
| WO2005023234A1 (en) * | 2003-08-29 | 2005-03-17 | Yves Saint Laurent Parfums | Molecules exhibiting anti-adipogenic activity on adipocyte human cells |
| FR2859104A1 (en) * | 2003-08-29 | 2005-03-04 | Saint Laurent Parfums | MOLECULES WITH ANTI-ADIPOGENIC ACTIVITY ON HUMAN ADIPOCYTE CELLS |
| EP1541041A1 (en) * | 2003-12-10 | 2005-06-15 | Synergia Holding | Pharmaceutical and/or dietary compositions against stress |
| FR2863497A1 (en) * | 2003-12-10 | 2005-06-17 | Synergia Holding | NEW PHARMACEUTICAL AND / OR DIETETIC COMPOSITIONS AGAINST STRESS |
| WO2008064297A1 (en) * | 2006-11-21 | 2008-05-29 | The Coca-Cola Company | Nutritional beverage for optimal bone health |
| US20110177010A1 (en) * | 2007-11-27 | 2011-07-21 | Nutri Team Gmbh | Vitamin preparation |
| US20150164825A1 (en) * | 2008-06-03 | 2015-06-18 | John Ray Biffin | Method for increasing bone density and/or reducing any osteochondral defects in an animal and a composition including vitamin k |
| EP2135621A1 (en) * | 2008-06-18 | 2009-12-23 | Roberto Fasani | Combined formulations for the treatment of the male infertility |
| AT510810A1 (en) * | 2010-12-09 | 2012-06-15 | Gonadosan Gmbh | COMBINATION PROCEDURE FOR IMPROVING FEMALE FERTILITY |
| AT510810B1 (en) * | 2010-12-09 | 2017-09-15 | Gonadosan Gmbh | COMBINATION PROCEDURE FOR IMPROVING FEMALE FERTILITY |
| US8183227B1 (en) | 2011-07-07 | 2012-05-22 | Chemo S. A. France | Compositions, kits and methods for nutrition supplementation |
| CN102319263A (en) * | 2011-08-17 | 2012-01-18 | 江门市新会区光华生物科技有限公司 | Film coated tablets containing a plurality of vitamins and mineral matters, and its preparation process |
| JP2013056867A (en) * | 2011-09-09 | 2013-03-28 | Pias Arise Kk | Kit for adjusting circadian rhythm and method for adjusting circadian rhythm |
| US8168611B1 (en) | 2011-09-29 | 2012-05-01 | Chemo S.A. France | Compositions, kits and methods for nutrition supplementation |
| US8545896B2 (en) | 2011-09-29 | 2013-10-01 | Chemo S. A. France | Compositions, kits and methods for nutrition supplementation |
| WO2014155370A1 (en) * | 2013-03-29 | 2014-10-02 | Omega Pharma Innovation & Development Nv | Kit with multiple nutritional supplements and a method for assembling thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| AU2002241408A1 (en) | 2002-10-08 |
| WO2002076436A3 (en) | 2003-03-13 |
| NL1017707C2 (en) | 2002-10-01 |
| EP1469746A2 (en) | 2004-10-27 |
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