WO2003024518A3 - Microstructures for delivering a composition cutaneously to skin using rotatable structures - Google Patents

Microstructures for delivering a composition cutaneously to skin using rotatable structures Download PDF

Info

Publication number
WO2003024518A3
WO2003024518A3 PCT/US2002/029228 US0229228W WO03024518A3 WO 2003024518 A3 WO2003024518 A3 WO 2003024518A3 US 0229228 W US0229228 W US 0229228W WO 03024518 A3 WO03024518 A3 WO 03024518A3
Authority
WO
WIPO (PCT)
Prior art keywords
skin
microelements
composition
stratum corneum
microstructures
Prior art date
Application number
PCT/US2002/029228
Other languages
French (fr)
Other versions
WO2003024518A2 (en
Inventor
Vladimir Gartstein
Faiz Feisal Sherman
Original Assignee
Procter & Gamble
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US09/952,391 external-priority patent/US7108681B2/en
Priority claimed from US10/216,148 external-priority patent/US20040087992A1/en
Application filed by Procter & Gamble filed Critical Procter & Gamble
Priority to JP2003528611A priority Critical patent/JP2005503210A/en
Priority to CA002456626A priority patent/CA2456626C/en
Priority to EP02798965A priority patent/EP1425064A2/en
Priority to AU2002333636A priority patent/AU2002333636A1/en
Publication of WO2003024518A2 publication Critical patent/WO2003024518A2/en
Publication of WO2003024518A3 publication Critical patent/WO2003024518A3/en

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/20—Surgical instruments, devices or methods, e.g. tourniquets for vaccinating or cleaning the skin previous to the vaccination
    • A61B17/205—Vaccinating by means of needles or other puncturing devices
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B17/322—Skin grafting apparatus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00761—Removing layer of skin tissue, e.g. wrinkles, scars or cancerous tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B2017/00743—Type of operation; Specification of treatment sites
    • A61B2017/00747—Dermatology
    • A61B2017/00765—Decreasing the barrier function of skin tissue by radiated energy, e.g. using ultrasound, using laser for skin perforation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B17/00—Surgical instruments, devices or methods, e.g. tourniquets
    • A61B17/32—Surgical cutting instruments
    • A61B2017/320004—Surgical cutting instruments abrasive
    • A61B2017/320008—Scrapers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0023—Drug applicators using microneedles
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/003—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a lumen
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M37/00—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin
    • A61M37/0015—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles
    • A61M2037/0038—Other apparatus for introducing media into the body; Percutany, i.e. introducing medicines into the body by diffusion through the skin by using microneedles having a channel at the side surface

Abstract

An improved method and apparatus (600) is provided as a system to deliver a composition, preferably a medical or pharmaceutical composition or active, through the stratum corneum of skin, without introducing bleeding or damage to tissue, and absent pain or other trauma. The dimensions and shapes of the microelements (12) are controlled so as to control the penetration depth into the skin. The microelements can be 'hollow' such that passageways (626) are created therethrough to allow the composition to flow from a chamber (476), through the microelements, and into the skin. Alternatively, the microelements can be 'solid' (622), and the composition is applied directly to the skin just before or just after the microelements are applied to the skin surface to create the openings in the stratum corneum. Another alternative embodiment uses cylindrical microstructures that are rotatably applied to the skin and which penetrate through the stratum corneum; and which can dispense fluid by various different structures.
PCT/US2002/029228 2001-09-14 2002-09-13 Microstructures for delivering a composition cutaneously to skin using rotatable structures WO2003024518A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
JP2003528611A JP2005503210A (en) 2001-09-14 2002-09-13 Microstructure for delivering compositions to the skin through the skin using a rotatable structure
CA002456626A CA2456626C (en) 2001-09-14 2002-09-13 Microstructures for delivering a composition cutaneously to skin using rotatable structures
EP02798965A EP1425064A2 (en) 2001-09-14 2002-09-13 Microstructures for delivering a composition cutaneously to skin using rotatable structures
AU2002333636A AU2002333636A1 (en) 2001-09-14 2002-09-13 Microstructures for delivering a composition cutaneously to skin using rotatable structures

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US09/952,391 2001-09-14
US09/952,391 US7108681B2 (en) 2000-10-16 2001-09-14 Microstructures for delivering a composition cutaneously to skin
US10/216,148 2002-08-09
US10/216,148 US20040087992A1 (en) 2002-08-09 2002-08-09 Microstructures for delivering a composition cutaneously to skin using rotatable structures

Publications (2)

Publication Number Publication Date
WO2003024518A2 WO2003024518A2 (en) 2003-03-27
WO2003024518A3 true WO2003024518A3 (en) 2003-09-25

Family

ID=26910709

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2002/029228 WO2003024518A2 (en) 2001-09-14 2002-09-13 Microstructures for delivering a composition cutaneously to skin using rotatable structures

Country Status (5)

Country Link
EP (1) EP1425064A2 (en)
JP (1) JP2005503210A (en)
AU (1) AU2002333636A1 (en)
CA (1) CA2456626C (en)
WO (1) WO2003024518A2 (en)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient

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US6821281B2 (en) 2000-10-16 2004-11-23 The Procter & Gamble Company Microstructures for treating and conditioning skin
US7828827B2 (en) 2002-05-24 2010-11-09 Corium International, Inc. Method of exfoliation of skin using closely-packed microstructures
US6663820B2 (en) 2001-03-14 2003-12-16 The Procter & Gamble Company Method of manufacturing microneedle structures using soft lithography and photolithography
IL152912A0 (en) * 2002-11-18 2003-06-24 Nanopass Ltd Micro needle systems
US7888546B2 (en) 2003-07-03 2011-02-15 Corium International, Inc. Wound dressing, ingredient delivery device and IV hold-down, and method relating to same
JP4457229B2 (en) 2003-11-10 2010-04-28 エイジェンシー フォー サイエンス， テクノロジー アンド リサーチ Manufacture of microneedles and microneedles
JP2005246595A (en) * 2004-03-05 2005-09-15 Ritsumeikan Microneedle array and method of producing the same
BRPI0509806A (en) 2004-04-12 2007-09-18 Allergan Inc multi-site injection system
JP4659822B2 (en) 2004-04-30 2011-03-30 チョ，ギュング，スゥ Electric exfoliator
US20070078414A1 (en) 2005-08-05 2007-04-05 Mcallister Devin V Methods and devices for delivering agents across biological barriers
US9987475B2 (en) 2006-07-03 2018-06-05 Lotte Chemical Corporation Micro needle roller assembly
JP4821993B2 (en) * 2006-07-21 2011-11-24 芳一 飛永 Micro-implement and manufacturing method thereof
KR200451185Y1 (en) 2007-02-15 2010-12-01 (주)클리니칼레졸루션아시아 Module Type Microneedle Roller
GB2448493B (en) * 2007-04-16 2009-10-14 Dewan Fazlul Hoque Chowdhury Microneedle transdermal delivery device
US20100292723A1 (en) * 2007-12-07 2010-11-18 Myeong In Lee Disk needle roller
WO2009130926A1 (en) * 2008-04-22 2009-10-29 南部化成株式会社 Endermic method, needle organizer and endermic injector device
WO2009144624A1 (en) * 2008-05-28 2009-12-03 Koninklijke Philips Electronics N.V. Device for controlled drug delivery
JP5357257B2 (en) * 2008-09-03 2013-12-04 ディーティーエスラッブ カンパニー リミテッド Skin stimulator
US20110144591A1 (en) * 2009-12-11 2011-06-16 Ross Russell F Transdermal Delivery Device
WO2011140274A2 (en) 2010-05-04 2011-11-10 Corium International, Inc. Method and device for transdermal delivery of parathyroid hormone using a microprojection array
GB201107642D0 (en) 2011-05-09 2011-06-22 Univ Cork Method
ES2786508T3 (en) 2012-06-12 2020-10-13 Hisamitsu Pharmaceutical Co Microneedle sheet
CA2894280C (en) * 2012-12-06 2018-07-31 Srgi Holdings Llc Pixel array medical devices and methods
ES2743404T3 (en) 2012-12-21 2020-02-19 Corium Inc Matrix for therapeutic agent supply and manufacturing method
EP2968887B1 (en) 2013-03-12 2022-05-04 Corium, Inc. Microprojection applicators
EP2968118B1 (en) 2013-03-15 2022-02-09 Corium, Inc. Microarray for delivery of therapeutic agent and methods of use
EP2968119B1 (en) 2013-03-15 2019-09-18 Corium International, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
AU2014237279B2 (en) 2013-03-15 2018-11-22 Corium Pharma Solutions, Inc. Microarray with polymer-free microstructures, methods of making, and methods of use
CA2903459C (en) 2013-03-15 2024-02-20 Corium International, Inc. Multiple impact microprojection applicators and methods of use
EP3011992B1 (en) 2013-06-18 2019-10-16 Hisamitsu Pharmaceutical Co., Inc. Applicator
US10039911B2 (en) 2013-06-19 2018-08-07 Hisamitsu Pharmaceutical Co., Inc. Applicator
US9694142B2 (en) 2013-09-03 2017-07-04 Visage Sculpture, PLLC Device for percutaneous delivery of therapeutic agents, and a method for its use
EP3042690B1 (en) 2013-09-06 2021-04-14 Hisamitsu Pharmaceutical Co., Inc. Micro-needle sheet
CN106061544B (en) 2014-02-27 2019-11-26 久光制药株式会社 Microneedle thin slice
EP3188714A1 (en) 2014-09-04 2017-07-12 Corium International, Inc. Microstructure array, methods of making, and methods of use
JP6571680B2 (en) 2014-12-05 2019-09-04 久光製薬株式会社 Microneedle device system
US10004887B2 (en) * 2015-02-18 2018-06-26 Alma Therapeutics Ltd. Transdermal delivery assembly
US10857093B2 (en) 2015-06-29 2020-12-08 Corium, Inc. Microarray for delivery of therapeutic agent, methods of use, and methods of making
JP6799005B2 (en) 2015-12-15 2020-12-09 久光製薬株式会社 Microneedle sheet
CN109475728B (en) 2016-09-01 2021-09-14 久光制药株式会社 Microneedle sheet
CN109925590B (en) * 2019-03-28 2021-10-08 吴晓苏 Coupling agent is brushed fast and wiping arrangement

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US3918449A (en) * 1973-06-06 1975-11-11 Guerin A Ets Device for cutaneous therapeutic treatment
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US3918449A (en) * 1973-06-06 1975-11-11 Guerin A Ets Device for cutaneous therapeutic treatment
FR2535602A1 (en) * 1982-11-05 1984-05-11 Stallergenes Lab Scarifying device
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Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8911749B2 (en) 2007-04-16 2014-12-16 Corium International, Inc. Vaccine delivery via microneedle arrays
US9114238B2 (en) 2007-04-16 2015-08-25 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9452280B2 (en) 2007-04-16 2016-09-27 Corium International, Inc. Solvent-cast microprotrusion arrays containing active ingredient
US9498524B2 (en) 2007-04-16 2016-11-22 Corium International, Inc. Method of vaccine delivery via microneedle arrays

Also Published As

Publication number Publication date
AU2002333636A1 (en) 2003-04-01
CA2456626C (en) 2009-01-20
WO2003024518A2 (en) 2003-03-27
JP2005503210A (en) 2005-02-03
EP1425064A2 (en) 2004-06-09
CA2456626A1 (en) 2003-03-27

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