WO2003092599A3 - Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent - Google Patents

Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent Download PDF

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Publication number
WO2003092599A3
WO2003092599A3 PCT/US2003/013463 US0313463W WO03092599A3 WO 2003092599 A3 WO2003092599 A3 WO 2003092599A3 US 0313463 W US0313463 W US 0313463W WO 03092599 A3 WO03092599 A3 WO 03092599A3
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WO
WIPO (PCT)
Prior art keywords
cox
flavans
present
mixture
free
Prior art date
Application number
PCT/US2003/013463
Other languages
French (fr)
Other versions
WO2003092599A2 (en
Inventor
Qi Jia
Original Assignee
Unigen Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to AU2003228777A priority Critical patent/AU2003228777C1/en
Application filed by Unigen Pharmaceuticals Inc filed Critical Unigen Pharmaceuticals Inc
Priority to EP03726548A priority patent/EP1503778B1/en
Priority to KR1020037008922A priority patent/KR100621234B1/en
Priority to AT03726548T priority patent/ATE438393T1/en
Priority to BRPI0309689-0A priority patent/BRPI0309689B1/en
Priority to DE60328676T priority patent/DE60328676D1/en
Priority to DK03726548T priority patent/DK1503778T3/en
Priority to NZ535988A priority patent/NZ535988A/en
Priority to CA2484192A priority patent/CA2484192C/en
Priority to JP2004500784A priority patent/JP4723239B2/en
Publication of WO2003092599A2 publication Critical patent/WO2003092599A2/en
Publication of WO2003092599A3 publication Critical patent/WO2003092599A3/en
Priority to HK05105928.1A priority patent/HK1073247A1/en

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    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61K31/33Heterocyclic compounds
    • A61K31/335Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/35Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
    • A61K31/352Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline 
    • A61K31/3533,4-Dihydrobenzopyrans, e.g. chroman, catechin
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    • A61K31/7048Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
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Abstract

The present invention provides a novel composition of matter comprised of a mixture of two specific classes of compounds --Free-B-ring flavonoids and flavans-- for use in the prevention and treatment of diseases and conditions mediated by the COX-2 and 5-LO pathways. The present invention further provides a novel method for simultaneously inhibiting the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) enzymes, and reducing cox-2 mRNA production. Finally, the present invention includes a method for weight loss and blood glucose control. The methods of this invention are comprised of administering to a host in need thereof an effective amount of the composition of this invention together with a pharmaceutically acceptable carrier. This invention relates generally to the prevention and treatment of diseases and conditions mediated by the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways, including but not limited to the relief joint discomfort and pain associated with conditions such as osteoarthritis, rheumatoid arthritis, and other injuries that result from overuse.
PCT/US2003/013463 2002-04-30 2003-04-30 Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent WO2003092599A2 (en)

Priority Applications (11)

Application Number Priority Date Filing Date Title
DE60328676T DE60328676D1 (en) 2002-04-30 2003-04-30 FORMULATION OF A MIXTURE OF FLAVONOIDS AND FLAVANES WITH FREE B RING AS A THERAPEUTIC AGENT
EP03726548A EP1503778B1 (en) 2002-04-30 2003-04-30 Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent
KR1020037008922A KR100621234B1 (en) 2002-04-30 2003-04-30 Formulation of a Mixture of Free-B-Ring Flavonoids and Flavans as a Therapeutic Agent
AT03726548T ATE438393T1 (en) 2002-04-30 2003-04-30 FORMULATION OF A MIXTURE OF FLAVONOIDS AND FLAVANES WITH FREE B RING AS A THERAPEUTIC AGENT
BRPI0309689-0A BRPI0309689B1 (en) 2002-04-30 2003-04-30 COMPOSITIONS COMPRISING A MIXTURE OF B-RING-FREE FLAVONOIDS AND FLAVANES AND USES THEREOF
AU2003228777A AU2003228777C1 (en) 2002-04-30 2003-04-30 Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent
DK03726548T DK1503778T3 (en) 2002-04-30 2003-04-30 Formulation of a mixture of flavonoids and flavans with free B-ring as therapeutic agent
JP2004500784A JP4723239B2 (en) 2002-04-30 2003-04-30 Formulation of a mixture of free-B-ring flavonoids and flavans as therapeutic agents
CA2484192A CA2484192C (en) 2002-04-30 2003-04-30 Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent
NZ535988A NZ535988A (en) 2002-04-30 2003-04-30 Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent
HK05105928.1A HK1073247A1 (en) 2002-04-30 2005-07-12 Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US37716802P 2002-04-30 2002-04-30
US60/377,168 2002-04-30

Publications (2)

Publication Number Publication Date
WO2003092599A2 WO2003092599A2 (en) 2003-11-13
WO2003092599A3 true WO2003092599A3 (en) 2004-03-11

Family

ID=29401452

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US2003/013463 WO2003092599A2 (en) 2002-04-30 2003-04-30 Formulation of a mixture of free-b-ring flavonoids and flavans as a therapeutic agent

Country Status (16)

Country Link
US (5) US7514469B2 (en)
EP (2) EP2108370A1 (en)
JP (2) JP4723239B2 (en)
KR (1) KR100621234B1 (en)
CN (2) CN101837003B (en)
AT (1) ATE438393T1 (en)
AU (1) AU2003228777C1 (en)
BR (1) BRPI0309689B1 (en)
CA (2) CA2703698C (en)
DE (1) DE60328676D1 (en)
DK (1) DK1503778T3 (en)
ES (1) ES2330097T3 (en)
HK (2) HK1073247A1 (en)
NZ (1) NZ535988A (en)
RU (1) RU2379031C2 (en)
WO (1) WO2003092599A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945518B2 (en) 2002-04-30 2015-02-03 Unigen, Inc. Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions

Families Citing this family (94)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20050096281A1 (en) * 2002-03-01 2005-05-05 Unigen Pharmaceuticals, Inc. Formulation of a mixture of Free-B-Ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
US7108868B2 (en) 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
EP2108370A1 (en) 2002-04-30 2009-10-14 Unigen Pharmaceuticals, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent
US8034387B2 (en) * 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
US20040097429A1 (en) * 2002-11-18 2004-05-20 Nieuwenhuizen Arie Gijsbert Method for the reduction of the mammalian appetite
WO2004075844A2 (en) * 2003-02-26 2004-09-10 Unigen Pharmaceuticals, Inc. Formulation for use in the prevention and treatment of carbohydrate induced diseases and conditions
BRPI0409179A (en) 2003-04-04 2006-05-02 Unigen Pharmaceuticals Inc formulation of dual cyclooxygenase (cox) and lipoxygenase (lox) inhibitors for mammalian skin care
JP2007502288A (en) 2003-08-12 2007-02-08 スリーエム イノベイティブ プロパティズ カンパニー Oxime-substituted imidazo-containing compounds
AU2004268625B2 (en) 2003-08-27 2011-03-31 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
JP2007504269A (en) 2003-09-05 2007-03-01 スリーエム イノベイティブ プロパティズ カンパニー Method for treating CD5 + B cell lymphoma
ES2544477T3 (en) 2003-10-03 2015-08-31 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
US7544697B2 (en) 2003-10-03 2009-06-09 Coley Pharmaceutical Group, Inc. Pyrazolopyridines and analogs thereof
EP1682544A4 (en) 2003-11-14 2009-05-06 3M Innovative Properties Co Hydroxylamine substituted imidazo ring compounds
CA2545774A1 (en) 2003-11-14 2005-06-02 3M Innovative Properties Company Oxime substituted imidazo ring compounds
NZ547467A (en) 2003-11-25 2010-06-25 3M Innovative Properties Co Substituted imidazo ring system and methods
JP2007517035A (en) 2003-12-29 2007-06-28 スリーエム イノベイティブ プロパティズ カンパニー Arylalkenyl and arylalkynyl substituted imidazoquinolines
EP1699788A2 (en) 2003-12-30 2006-09-13 3M Innovative Properties Company Imidazoquinolinyl, imidazopyridinyl and imidazonaphthyridinyl sulfonamides
US8697873B2 (en) 2004-03-24 2014-04-15 3M Innovative Properties Company Amide substituted imidazopyridines, imidazoquinolines, and imidazonaphthyridines
AU2005249147B2 (en) 2004-06-04 2011-03-24 Poly Gain Pte Ltd Natural sweetener
WO2005123080A2 (en) 2004-06-15 2005-12-29 3M Innovative Properties Company Nitrogen-containing heterocyclyl substituted imidazoquinolines and imidazonaphthyridines
US8026366B2 (en) 2004-06-18 2011-09-27 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
WO2006038923A2 (en) 2004-06-18 2006-04-13 3M Innovative Properties Company Aryl substituted imidazonaphthyridines
WO2006065280A2 (en) 2004-06-18 2006-06-22 3M Innovative Properties Company Isoxazole, dihydroisoxazole, and oxadiazole substituted imidazo ring compounds and methods
KR100610562B1 (en) * 2004-06-28 2006-08-08 재단법인서울대학교산학협력재단 Compositions for preventing or treating an acute or chronic neurodegenerative diseases comprising flavonoide derivatives
KR100545304B1 (en) * 2004-09-01 2006-05-08 주식회사 유니젠 Composition comprising uncaria genus plant having uncaria gambir, or scutellaria radix and/or green tea extract mixture for suppressing cyclooxygenase or 5-lipoxygenase
CA2584528A1 (en) * 2004-09-17 2006-03-23 Oystershell Nv Composition for inhibiting or preventing the formation of a biofilm
TW200630102A (en) * 2004-10-19 2006-09-01 Unigen Pharmaceuticals Inc Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions
US20060140881A1 (en) 2004-12-22 2006-06-29 Guofeng Xu Oral care compositions containing flavonoids and flavans
CN101141999A (en) * 2004-12-22 2008-03-12 高露洁-棕榄公司 Oral care compositions containing free-b-ring flavonoids andflavans
ES2392647T3 (en) 2004-12-30 2012-12-12 3M Innovative Properties Company Chiral tetracyclic compounds that induce interferon biosynthesis
US8034938B2 (en) 2004-12-30 2011-10-11 3M Innovative Properties Company Substituted chiral fused [1,2]imidazo[4,5-c] ring compounds
WO2006084251A2 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune reponse modifiers
US7968563B2 (en) 2005-02-11 2011-06-28 3M Innovative Properties Company Oxime and hydroxylamine substituted imidazo[4,5-c] ring compounds and methods
JP4823538B2 (en) * 2005-02-28 2011-11-24 株式会社mimozax Anti-obesity composition containing acacia bark
CN101175406B (en) * 2005-03-10 2012-11-21 尤尼根公司 Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent
EP1869043A2 (en) 2005-04-01 2007-12-26 Coley Pharmaceutical Group, Inc. Pyrazolopyridine-1,4-diamines and analogs thereof
AU2006232375A1 (en) 2005-04-01 2006-10-12 Coley Pharmaceutical Group, Inc. 1-substituted pyrazolo (3,4-c) ring compounds as modulators of cytokine biosynthesis for the treatment of viral infections and neoplastic diseases
CN101203270B (en) * 2005-06-03 2014-07-02 视界科技有限公司 Substances having body mass redistribution properties
KR100729731B1 (en) 2005-07-19 2007-06-20 건국대학교 산학협력단 3,4'-dihydroxyflavone having activity of suppressing apoptosis of keratinocyte
AU2006308596A1 (en) * 2005-11-01 2007-05-10 Mars, Incorporated Flavanols and B-type procyanidins and inflammation
JP2009518439A (en) * 2005-12-09 2009-05-07 メタプロテオミクス,エルエルシー Protein kinase regulation by hops and acacia products
US20070140990A1 (en) 2005-12-21 2007-06-21 Nataly Fetissova Oral Compositions Comprising Propolis
WO2007108042A1 (en) * 2006-03-15 2007-09-27 Tropical Technology Center Ltd. Antiinflammatory agent
US20080003300A1 (en) * 2006-06-30 2008-01-03 Gaffar Maria C Compostions containing Mg/Zn/F-CaP plus inhibitors of pro-inflammatory Cytokines (a combination of a Free-B-Ring flavonoids and a flavan) for osteoporosis prevention, therapy and treatment of bone diseases
WO2008008432A2 (en) 2006-07-12 2008-01-17 Coley Pharmaceutical Group, Inc. Substituted chiral fused( 1,2) imidazo (4,5-c) ring compounds and methods
US9682256B2 (en) * 2006-07-14 2017-06-20 Colgate-Palmolive Company Methods of making compositions comprising films
KR20140011430A (en) 2006-08-10 2014-01-28 가부시키가이샤 미모잭스 Antioxidant composition containing component originating in the bark of tree belonging to the genus acacia
US8128969B2 (en) 2006-08-10 2012-03-06 Mimozax Co., Ltd. Hypoglycemic composition containing acacia bark derivative
US8124138B2 (en) 2006-08-10 2012-02-28 Mimozax Co., Ltd. Composition for prevention and/or treatment of pruritus containing acacia bark derivative
CN101505776B (en) * 2006-08-10 2013-12-04 株式会社mimozax Antiobesity composition containing component originating in the bark of tree belonging to the genus acacia
CN101505777B (en) * 2006-08-10 2012-05-30 株式会社mimozax Composition for preventing and/or treating tumor containing component originating in the bark of tree belonging to the genus acacia
MX2009002413A (en) * 2006-09-19 2009-03-20 Horizon Science Pty Ltd Extracts derived from sugar cane and a process for their manufacture.
KR100761248B1 (en) 2006-10-12 2007-10-04 주식회사 유니젠 Composition for treating atopic dermatitis comprising extracts of bamboo and scutellaria
US8517728B2 (en) 2007-01-24 2013-08-27 Colgate-Palmolive Company Oral care implement having fluid delivery system
US20080261898A1 (en) * 2007-04-17 2008-10-23 Liao Heather H Composition and method for cancer treatment and prevention
CN101938983A (en) * 2008-02-08 2011-01-05 高露洁-棕榄公司 Oral care product and methods of use thereof
MX2010009314A (en) * 2008-02-25 2010-09-24 Nestec Sa Polyphenols for the treatment of cartilage disorders.
TWI366466B (en) * 2008-05-08 2012-06-21 Ind Tech Res Inst Herbal extracts capable of inducing immune cells to produce interferon and activating toll-like receptors and the preparation thereof
TWI522109B (en) * 2009-01-26 2016-02-21 臺北醫學大學 Use of pterosin compounds for treating diabetes and obesity
NZ624963A (en) 2009-04-29 2016-07-29 Amarin Pharmaceuticals Ie Ltd Pharmaceutical compositions comprising epa and a cardiovascular agent and methods of using the same
KR101582907B1 (en) * 2010-10-27 2016-01-08 주식회사 성균바이오텍 Composition comprising extract of Eupatorium spp. as an effective component for prevention or treatment of obesity or metabolic bone disease
WO2012106761A1 (en) 2011-02-08 2012-08-16 Horizon Science Pty Ltd Sugar extracts
AU2011361752B2 (en) 2011-03-09 2015-01-22 Colgate-Palmolive Company Interdental cleaning device
KR20120132114A (en) * 2011-05-27 2012-12-05 한국생명공학연구원 Pharmaceutical composition for the prevention or treatment of asthma containing wogonin as an effective ingredient
JP6203469B2 (en) * 2011-06-03 2017-09-27 花王株式会社 Dentifrice composition
CN102579590A (en) * 2012-02-18 2012-07-18 贾古友 Drug for treating knee osteoarthritis (OA)
US10357508B2 (en) 2012-03-19 2019-07-23 Buck Institute For Research On Aging APP specific BACE inhibitors (ASBIs) and uses thereof
CN102755311A (en) * 2012-07-05 2012-10-31 吉林大学 Application of oroxylin A in preparing medicament for treating pneumonia
CN104780987B (en) 2012-08-28 2018-10-30 产品制造商(澳大利亚)有限公司 extracting method
US9897565B1 (en) 2012-09-11 2018-02-20 Aseko, Inc. System and method for optimizing insulin dosages for diabetic subjects
US9171343B1 (en) 2012-09-11 2015-10-27 Aseko, Inc. Means and method for improved glycemic control for diabetic patients
MX357206B (en) 2012-10-26 2018-06-29 Colgate Palmolive Co Oral care implement.
TWI825378B (en) 2013-06-17 2023-12-11 美商優力竟股份有限公司 Compositions and methods for joint health
WO2015015509A2 (en) * 2013-08-02 2015-02-05 Council Of Scientific & Industrial Research Ulmoside-a: useful for prevention or cure of metabolic diseases
WO2015021512A1 (en) 2013-08-16 2015-02-19 Horizon Science Pty Ltd Sugar cane derived extracts and methods of treatment
US9486580B2 (en) 2014-01-31 2016-11-08 Aseko, Inc. Insulin management
US9898585B2 (en) 2014-01-31 2018-02-20 Aseko, Inc. Method and system for insulin management
AU2015277265B2 (en) * 2014-06-16 2018-03-01 Unigen, Inc. Compositions and methods for managing or improving bone disorders, cartilage disorders, or both
US10583161B2 (en) * 2014-06-16 2020-03-10 Unigen, Inc. Compositions and methods for managing or improving bone disorders, joint disorders, cartilage disorders, or a combination thereof
CN104083390A (en) * 2014-06-28 2014-10-08 广西大学 Application of 6,7-dyhydroxyl-5-beta-D-glucopyranose-4'-beta-O-D-glucopyranose flavonoid in preparing anti-inflammation medicaments
US11081226B2 (en) 2014-10-27 2021-08-03 Aseko, Inc. Method and controller for administering recommended insulin dosages to a patient
US9892234B2 (en) 2014-10-27 2018-02-13 Aseko, Inc. Subcutaneous outpatient management
CN104721210B (en) * 2015-03-16 2017-10-13 中国药科大学 Application of the oroxylin glycosides in medicine for treating tumor metastasis is prepared
EP3337402A4 (en) 2015-08-20 2019-04-24 Aseko, Inc. Diabetes management therapy advisor
CN106727492A (en) * 2016-12-22 2017-05-31 黄冈师范学院 A kind of application of polymethoxyflavone on the medicine for preparing treatment cutaneous papilloma
EP3638277A4 (en) * 2017-06-15 2021-03-17 Sami Labs Limited Compositions and methods for beta secretase inhibition
US20210052543A1 (en) * 2018-01-09 2021-02-25 Brigham Young University Compositions and Methods for Treating Pain with Wogonin
CN108610394B (en) * 2018-05-07 2021-08-31 深圳市维琪医药研发有限公司 Preparation and purification method and application of peptidomimetic compound
CN111803632B (en) 2019-04-09 2022-04-29 北京五和博澳药业股份有限公司 Flavone polyphenol medicine self-emulsifying composition, preparation method thereof, medicine composition and application
US11351102B2 (en) * 2019-08-26 2022-06-07 Sami-Sabinsa Group Limited Plant actives and their anti-pollution effects thereof
CA3187750A1 (en) 2020-07-30 2022-02-03 Mesfin Yimam A standardized bioflavonoid composition for regulation of homeostasis of host defense mechanism
CN112156120B (en) * 2020-11-09 2021-11-02 中国科学院新疆理化技术研究所 Application of Turkey jasmine leaf n-butyl alcohol extract
DE202022106782U1 (en) 2022-12-03 2022-12-19 Mohammed Azeemuddin Antiurolithiatic, antiosteoporotic, antidiabetic and anti-inflammatory composition of a polyherbal extract

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03240725A (en) * 1990-02-15 1991-10-28 Senjiyu Seiyaku Kk Maillard reaction inhibitor
US5886029A (en) * 1997-09-05 1999-03-23 Dhaliwal; Kirpal S. Method and composition for treatment of diabetes
EP0956867A1 (en) * 1998-05-12 1999-11-17 Franz-Peter Dr. Liebel Use of flavonoid glycosides, tanning agents and microorganisms for the therapy and prophylaxis of diabetes mellitus
US6093403A (en) * 1997-08-01 2000-07-25 Phytocell Research, Inc. Sugar imbalance and diabetes treating herbal formulation
JP2002053484A (en) * 2000-08-07 2002-02-19 Asahi Breweries Ltd Lipase inhibitor, and food and drink containing the same

Family Cites Families (200)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3686872A (en) * 1970-06-30 1972-08-29 Anthony James Whitworth Soil grouting process
US3706581A (en) * 1970-10-05 1972-12-19 Borden Co Soil grouting process and composition
US4035510A (en) 1976-09-15 1977-07-12 Scott Eugene J Van Treatment of acne utilizing N-methyldiethanolamine
US4201776A (en) 1977-01-31 1980-05-06 The Green Cross Corporation Food additive for reinforcing foods deficient in fiber content
GB2024817B (en) 1978-03-15 1982-09-22 Wellcome Found Flavan derivatives
US4268517A (en) * 1979-08-30 1981-05-19 Continental Pharma Pharmaceutical composition and therapeutical method for treating degenerative affections of the articular cartilage
JPS5738721A (en) 1980-08-20 1982-03-03 Wataru Sakai Production of bamboo extract having effect for hemorrhoids
JPS57109720A (en) * 1980-12-22 1982-07-08 Continentalfuaama Medicine containing (+)-catechine and/or its salt for degenerated disease of articular gristle
US4374824A (en) * 1981-01-27 1983-02-22 Krishan Dyal Mathur Dentifrice
GB2115409B (en) 1982-02-24 1985-08-07 Zyma Sa Novel crystal modifications of (+)-catechin
JPS6150921A (en) 1984-08-20 1986-03-13 Ichimaru Fuarukosu Kk Purification of baicalin
JPS6183179A (en) 1984-09-28 1986-04-26 Otsuka Pharmaceut Co Ltd Novel flavone derivative
JPS61161219A (en) 1985-01-08 1986-07-21 Osaka Chem Lab Skin composition for atopic dermatitis
JPS61233627A (en) 1985-04-10 1986-10-17 Agency Of Ind Science & Technol Agent for suppressing degranulation of mastocyte
JPS61238719A (en) 1985-04-17 1986-10-24 Shiseido Co Ltd Hair cosmetic
JPH0755895B2 (en) 1985-08-29 1995-06-14 サンスター株式会社 Toothpaste composition
US4627977A (en) 1985-09-13 1986-12-09 Colgate-Palmolive Company Anticalculus oral composition
JPS6327435A (en) 1986-07-18 1988-02-05 Ichimaru Pharcos Co Ltd Extracting method for extract with high baicalein content
WO1988000970A2 (en) 1986-08-08 1988-02-11 Regents Of The University Of Minnesota Method of culturing leukocytes
US5156835A (en) 1987-01-30 1992-10-20 Colgate-Palmolive Company Antibacterial antiplaque oral composition
IN168400B (en) 1987-01-30 1991-03-23 Colgate Palmolive Co
CA1308661C (en) 1987-06-26 1992-10-13 Masayasu Kurono AGENT FOR INHIBITING BINDING OF 5.alpha.-DIHYDRO-TESTOSTERONE WITH ANDROGEN RECEPTOR AS WELL AS PROCESS FOR OBTAINING SAME
US5098709A (en) 1987-07-21 1992-03-24 Kang Kwon J Method of administrating a fused salt from natural substances, namely ginkgo, persimmon, pine, and bamboo in the treatment of inflammations
JPH0662408B2 (en) 1987-10-01 1994-08-17 太陽化学株式会社 Anti-caries and anti-periodontal composition
FR2628317B1 (en) * 1988-03-09 1991-11-08 Lvmh Rech COMPOSITION BASED ON HYDRATED LIPID LAMID PHASES OR LIPOSOMES CONTAINING SCUTELLARIA EXTRACT, OR AT LEAST ONE FLAVONOID SUCH AS BAICALINE OR BAICALINE AND COSMETIC OR PHARMACEUTICAL COMPOSITION, IN PARTICULAR DERMATOLOGICAL, ANTI-ALLERGIC ANTI-ALLERGIC ACTIVITY THE INCORPORANT
US4965067A (en) 1988-08-10 1990-10-23 The Proctor & Gamble Company Oral compositions
US4942333A (en) 1988-12-05 1990-07-17 North American Philips Corporation Shadow mask with border pattern
JPH0755895Y2 (en) 1989-04-04 1995-12-25 函館製網船具株式会社 Multi-stage aquaculture cage
US4946684A (en) 1989-06-20 1990-08-07 American Home Products Corporation Fast dissolving dosage forms
FR2651132B1 (en) * 1989-08-30 1993-01-08 Pacific Chem Co Ltd PROTECTIVE AGENTS FOR CELLS AGAINST CHEMICAL SPECIES WITH ACTIVE OXYGEN AND THEIR PREPARATION.
JPH03251518A (en) 1990-02-26 1991-11-11 Ichimaru Pharcos Co Ltd Skin, scalp and hair agent containing component of suppressing growth of dandruff fungus extracted from bamboo
JP3133095B2 (en) * 1990-04-25 2001-02-05 兆岐 史 Gastrointestinal sclerosis agent
JP2704783B2 (en) 1990-05-23 1998-01-26 長谷川香料株式会社 Prevention method of flavor deterioration of food and drink
CN1028604C (en) 1990-06-13 1995-05-31 成都中医学院 Prepn. of Chinese herb-fresh bamboo-juice
US5585371A (en) 1990-08-29 1996-12-17 Humanetics Corporation Treatment of immune system with Δ5-androstenes
US5096701A (en) 1990-12-18 1992-03-17 The Procter & Gamble Company Oral compositions
JP3802555B2 (en) 1991-12-17 2006-07-26 フイズ テクノロジーズ リミテッド Ulcer prevention and treatment composition and method
JPH05271088A (en) 1991-12-27 1993-10-19 Ruibosuteii Japan:Kk Agent for improving and treating tissue disorder caused by dermatosis-immunological reaction
FR2687572B1 (en) 1992-02-26 1995-06-09 Oreal USE OF CERTAIN FLAVONOUIDS IN COSMETIC COMPOSITIONS, AND METHOD FOR PROTECTING THE SKIN, ITS PHANERES AND COSMETIC COMPOSITIONS.
JPH05331061A (en) 1992-06-01 1993-12-14 Tsumura & Co Apoptosis-inducing agent
JPH05331161A (en) 1992-05-27 1993-12-14 Tsumura & Co Chromone derivative and aldose reductase inhibitor containing the compound as active component
US5605929A (en) * 1992-05-27 1997-02-25 Arch Development Corp. Methods and compositions for inhibiting 5α-reductase activity
JPH08104268A (en) 1992-07-23 1996-04-23 Joji Maruyama Parking device for bicycle
US5650432A (en) * 1995-03-24 1997-07-22 Jlb, Inc. Method of treating or preventing non-viral microbial infection
US5320830A (en) 1992-12-30 1994-06-14 The Procter & Gamble Company Oral compositions
US5364845C1 (en) 1993-03-31 2002-09-10 Nutramax Lab Inc Glusosamine chondroitin and manganese composition for the protection and repair of connective tissue
JPH0710768A (en) 1993-05-24 1995-01-13 Suntory Ltd Hyaluronidase inhibitor containing extract of plant belonging to family leguminosae as active ingredient
CN1096680A (en) 1993-06-19 1994-12-28 金赞星 The medicine of treatment cerebrovascular
JP3529811B2 (en) 1993-06-30 2004-05-24 三省製薬株式会社 External preparation for skin
CN1093914A (en) 1993-07-04 1994-10-26 钟定铨 Ten thousand answer acute throat trouble to loose and manufacture method
JPH0725761A (en) 1993-07-09 1995-01-27 Kureha Chem Ind Co Ltd Agent for protecting cartilage
GB9317071D0 (en) 1993-08-17 1993-09-29 Univ Strathclyde Flavonoids
CN1101856A (en) * 1993-10-20 1995-04-26 宋海 Chinese medicine spray for curing burn and scald
JP3811198B2 (en) 1993-11-17 2006-08-16 株式会社創研 Antiallergic agent from rice
JP3222672B2 (en) 1993-12-16 2001-10-29 三井農林株式会社 Protein synthesis inhibitor
CN1043406C (en) 1993-12-27 1999-05-19 尚庆英 Method for preparation of compound Qingdaisan powder
JPH07223941A (en) 1994-02-14 1995-08-22 Nippon Ham Kk Anticomplementary substance
JP3412228B2 (en) 1994-02-23 2003-06-03 松下電器産業株式会社 Gas shut-off device
JPH07242555A (en) 1994-03-08 1995-09-19 Suntory Ltd Glucosyl transferase-inhibiting agent and dental caries-resistant agent and dental caries-resistant food containing the same as active ingredient
JP2711630B2 (en) 1994-04-07 1998-02-10 株式会社大阪薬品研究所 External preparation for skin
EP0768079B1 (en) 1994-06-30 2003-05-28 Kyowa Hakko Kogyo Co., Ltd. Hair growth stimulant
TW235922B (en) 1994-07-06 1994-12-11 Amboo Devise Co Ltd A production process of deodorant
JPH0826969A (en) 1994-07-15 1996-01-30 Osaka Yakuhin Kenkyusho:Kk Cosmetic composition
KR960003725A (en) 1994-07-16 1996-02-23 신국현 Treatment of cataracts with golden flavonoids
JPH08104628A (en) * 1994-10-04 1996-04-23 Sumitomo Pharmaceut Co Ltd Inhibitor of matrix metalloprotease
US5545411A (en) * 1994-12-16 1996-08-13 Bristol-Myers Squibb Company Method for lowering viscosity by use of gum acacia
KR960040370A (en) 1995-05-01 1996-12-17 강상모 Alcohol Disorder Prevention and Treatment Composition
US5589160A (en) 1995-05-02 1996-12-31 The Procter & Gamble Company Dentifrice compositions
CA2175985A1 (en) 1995-05-10 1996-11-11 Yoichi Kiyosuke Pharmaceutical composition containing substance inhibiting hsp47 production
JP3488325B2 (en) 1995-09-28 2004-01-19 株式会社大和生物研究所 Sasasa tea and its manufacturing method
GB2306321A (en) * 1995-10-24 1997-05-07 Anne Child The use of (+)-catechin in the treatment or prophylaxis of connective tissue disorders
JPH09227374A (en) 1996-02-28 1997-09-02 Taiyo Kagaku Co Ltd Composition for inhibiting production of stress protein
CN1159019C (en) 1996-04-02 2004-07-28 火星有限公司 Extractable compounds and method for making and using the same
JPH09278662A (en) 1996-04-10 1997-10-28 Nof Corp Antiallergic agent
JPH1025238A (en) 1996-07-10 1998-01-27 Mikimoto Pharmaceut Co Ltd Preparation for external use for skin
US5773014A (en) 1996-10-07 1998-06-30 Bioetica, Inc. Compositions and methods for inhibiting the formation of unwanted skin pigmentation
JPH10130162A (en) 1996-10-31 1998-05-19 Kanebo Ltd Hyaluronic acid decomposition inhibitor, agent for treatment of hyaluronic acid abnormal decomposition disease and cosmetic
US5817299A (en) 1996-11-01 1998-10-06 E-L Management Corp. Non-chemical sunscreen composition
US6197808B1 (en) * 1996-11-18 2001-03-06 Cancer Instititute (Hospital), Chinese Academy Of Medical Sciences Methods for treating hyperplasia
JP3213557B2 (en) * 1996-11-18 2001-10-02 三井農林株式会社 A remedy for condyloma acuminatum containing tea catechin as an active ingredient
US5968973A (en) 1996-11-18 1999-10-19 Cancer Institute (Hospital), Chinese Academy Of Medical Sciences Method for treating hyperplasia
JPH10167960A (en) 1996-12-12 1998-06-23 Les-Bell:Kk Hepatocyte cancer recurrence inhibitor
JPH10182415A (en) 1996-12-20 1998-07-07 Rashieru Seiyaku Kk Cosmetic composition
US5804168A (en) 1997-01-29 1998-09-08 Murad; Howard Pharmaceutical compositions and methods for protecting and treating sun damaged skin
US5962517A (en) * 1997-01-31 1999-10-05 Murad; Howard Pharmaceutical compositions and methods for treating acne
CN1189365A (en) 1997-01-31 1998-08-05 雷学军 Medicine for preventing Aids virus, treponema pallidum, neisseria gonorrhoeae and trichomonad
IN186803B (en) * 1997-02-05 2001-11-10 Panacea Biotec Ltd
GB9704904D0 (en) 1997-03-10 1997-04-30 Riley Fletcher Foundation The Essential oil composition
US5766614A (en) 1997-03-20 1998-06-16 Yong; Liu Burn treatment compositions containing herbal mix
WO1998042363A1 (en) 1997-03-21 1998-10-01 Shiseido Company, Ltd. Immunopotentiators
JPH10287528A (en) 1997-04-07 1998-10-27 Rashieru Seiyaku Kk Cosmetic composition
JP4231559B2 (en) * 1997-04-23 2009-03-04 オリザ油化株式会社 Lipoxygenase inhibitor
PL187310B1 (en) 1997-04-29 2004-06-30 Antoni Gwardys Natural antioxidative preparation
US6243841B1 (en) * 1997-05-30 2001-06-05 Texas Instruments Incorporated Automated test and evaluation sampling system and method
US5886155A (en) 1997-06-18 1999-03-23 Bioresources International Inc. Purification of miraculin glycoprotein using tandem hydrophobic interaction chromatography
IN1997DE01715A (en) 1997-06-24 2015-07-31 Council Scient Ind Res
KR19990015612A (en) 1997-08-07 1999-03-05 한영복 Hepatitis C Therapeutic Composition Containing Mixed Extracts of Hwangbaekpi and Matari Plants
WO1999018688A1 (en) 1997-10-02 1999-04-15 Nikko Co., Ltd. Apparatus for protecting against radiowave transmission from a mobile communication device
CN1062753C (en) 1997-10-21 2001-03-07 陈新学 Medicine for preventing and treating eye diseases
JP4738592B2 (en) 1997-10-31 2011-08-03 アーチ・デヴェロップメント・コーポレイション Methods and compositions for modulating 5α-reductase activity
US6696484B2 (en) * 1997-10-31 2004-02-24 University Of Chicago Office Of Technology And Intellectual Property Method and compositions for regulation of 5-alpha reductase activity
JPH11140497A (en) 1997-10-31 1999-05-25 Amyuure:Kk Catechin-containing soap
ID23921A (en) 1997-11-04 2000-05-25 Pfizer Prod Inc REPLACEMENT OF INDAZOLA BIOISOSTERE CATEGOL IN ACTIVE COMPOUNDS FOR THERAPY
US6221341B1 (en) 1997-11-19 2001-04-24 Oraceutical Llc Tooth whitening compositions
US6083921A (en) * 1998-01-12 2000-07-04 Xu; Kai Jian Pharmaceutical compositions and method of using same
US5922756A (en) 1998-02-14 1999-07-13 Chan; Marion Man-Ying Method of inhibiting nitric oxide synthase
CN1066055C (en) 1998-03-17 2001-05-23 浙江农业大学 Production method for extracting flavonoid compound extract or powder from bamboo leaf
US5908628A (en) 1998-05-01 1999-06-01 Hou; Liping Compositions with analgesic, antipyretic and antiinflammatory properties
FR2778663B1 (en) 1998-05-15 2001-05-18 Coletica NOVEL ESTERS OF FLAVONOIDS, THEIR USE IN COSMETICS, DERMOPHARMACY, PHARMACY AND AGRI-FOOD
US6043694A (en) 1998-06-24 2000-03-28 Siemens Aktiengesellschaft Lock arrangement for a calibrated DLL in DDR SDRAM applications
JP2000044481A (en) 1998-07-30 2000-02-15 Sunstar Inc Preparation for external use for skin
US6080401A (en) * 1998-11-19 2000-06-27 Reddy; Malireddy S. Herbal and pharmaceutical drugs enhanced with probiotics
JP4507027B2 (en) * 1998-12-04 2010-07-21 明治乳業株式会社 MMP inhibitor
US6194469B1 (en) 1998-12-11 2001-02-27 Board Of Trustees Operating Michigan State Univeristy Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids
US20020098207A1 (en) * 1999-02-08 2002-07-25 Daniel H. Maes Cholesterol sulfate compositions for enhancement of stratum corneum function
US6264926B1 (en) 1999-02-12 2001-07-24 Council Of Scientific And Industrial Research Formulation useful as a natural herbal tooth powder
US6241972B1 (en) 1999-02-19 2001-06-05 Block Drug Company, Inc. Oral care formulation for the treatment of sensitivity teeth
KR100317112B1 (en) 1999-03-18 2001-12-22 한영복 Pharmaceutical composition comprising mixed-extract of phellodendron cortex and anemarrhena rhizoma for alalgesic and anti-inflammation
EP1093376A1 (en) 1999-04-08 2001-04-25 Metagenics, Inc. Composition and method for treatment of inflammation and pain in mammals
US6333304B1 (en) 1999-04-20 2001-12-25 Teresa K. Bath Therapeutic compositions containing glucosamine, collagen and a bioflavanol for repair and maintenance of connective tissue
AU4550100A (en) 1999-05-05 2000-11-21 Herzog, Leslie J. Food product
JP4082823B2 (en) 1999-05-06 2008-04-30 日本メナード化粧品株式会社 Phototoxicity inhibitor
JP4521894B2 (en) * 1999-05-28 2010-08-11 明治乳業株式会社 Matrix metalloproteinase inhibitor
JP2003501381A (en) * 1999-06-07 2003-01-14 ユニバーシティ・オブ・シェフィールド Arthritis treatment
KR20010017481A (en) 1999-08-11 2001-03-05 신상국 A bervage composition for removal an acne and a method of manufacturing therof.
JP2001187744A (en) 1999-10-19 2001-07-10 Tasuku Okuda Cell activation agent and product using the same
US6264995B1 (en) * 1999-10-19 2001-07-24 Thomas Newmark Herbal composition for reducing inflammation and methods of using same
WO2001030341A1 (en) 1999-10-25 2001-05-03 Japan As Represented By Director General Of Agency Of National Cancer Center Cyclooxygenase-2 expression inhibitors
KR100390639B1 (en) 2000-01-12 2003-07-07 김미정 Manufacturing Method for Food Composition Containing Extracts of Bamboo Leaves
US6248341B1 (en) 2000-01-14 2001-06-19 Color Access, Inc. Method of treating topical angiogenesis-related disorders
JP2001220353A (en) 2000-02-07 2001-08-14 Noevir Co Ltd Phospholipase a2 inhibitor
US6290995B1 (en) * 2000-02-08 2001-09-18 Zhao Xinxian Plant drug for preventing cancer II
KR100364383B1 (en) 2000-02-10 2002-12-18 김호철 Extract of Scutellariae Radix having neuroprotective effects and pharmaceutical preparations containing the same
EP1127572A3 (en) * 2000-02-25 2003-05-02 Basf Aktiengesellschaft Use of flavones for treating cycloxygenase-2 mediated diseases
US20020086070A1 (en) * 2000-03-11 2002-07-04 Kuhrts Eric Hauser Anti-inflammatory and connective tissue repair formulations
CN1436074A (en) 2000-04-11 2003-08-13 宝生物工程株式会社 Remedies
US20030170186A1 (en) 2000-04-18 2003-09-11 Bernadette Geers Novel flavone glycoside derivatives for use in cosmetics, pharmaceuticals and nutrition
US20020016358A1 (en) 2000-04-19 2002-02-07 Nof Corporation Cosmetic composition
US6475530B1 (en) * 2000-05-31 2002-11-05 Eric H. Kuhrts Methods and compositions for producing weight loss
JP4719372B2 (en) 2000-06-21 2011-07-06 花王株式会社 PPAR-dependent gene transcription activator
US6319523B1 (en) 2000-06-29 2001-11-20 James H. Zhou Composition and method for inhibiting oral bacteria
ATE372764T1 (en) 2000-07-26 2007-09-15 Hououdou Co Ltd ANTIPRURITIC COMPOSITIONS AND COMPOSITIONS PROMOTING WOUND HEALING
WO2002009699A2 (en) 2000-07-28 2002-02-07 Immupharm Aps Method of treating symptoms of common cold, allergic rhinitis and infections relating to the respiratory tract
KR100417791B1 (en) 2000-08-14 2004-02-11 미즈코리아 주식회사 Antibiotic and cosmetic compositions containing herb medicines
CN1285202A (en) 2000-08-26 2001-02-28 田积天 Huoqingzhengyang medicine
KR20020031608A (en) 2000-10-19 2002-05-03 이응세 Scutellariae Radix extracts showing a good anti-microbial effect, preparing methods thereof and pharmaceutical compositions containing the same
JP4708675B2 (en) 2000-11-03 2011-06-22 プロテオテック・インコーポレーテッド Method for isolating amyloid inhibitory compounds from Uncaria tomentosa and related plants and use of the isolated compounds
FR2816839B1 (en) 2000-11-20 2003-09-26 Schwartz Laboratoires Robert PRODUCT PREPARING AND PROTECTING THE SKIN AGAINST UV RAYS, ACTING AGAINST CELLULAR AGING AND EXECUTING AN IMMUNOSTIMULANT ACTION
CA2431044A1 (en) 2000-12-13 2002-06-20 University Of Rochester Oral compositions and use thereof
JP2004517838A (en) * 2000-12-15 2004-06-17 ファルマシア・コーポレーション Selective COX-2 inhibition by non-edible plant extracts
EP1401460A2 (en) * 2000-12-15 2004-03-31 Pharmacia Corporation Selective cox-2 inhibition from plant extracts
US6555573B2 (en) * 2000-12-21 2003-04-29 The Quigley Corporation Method and composition for the topical treatment of diabetic neuropathy
US20020146467A1 (en) 2001-02-08 2002-10-10 Jung Kyu Yong Herbal composition for the prevention and treatment of dementia
US6391346B1 (en) * 2001-04-05 2002-05-21 Thomas Newmark Anti-inflammatory, sleep-promoting herbal composition and method of use
US6387416B1 (en) * 2001-04-05 2002-05-14 Thomas Newmark Anti-Inflammatory herbal composition and method of use
JP4901025B2 (en) 2001-06-22 2012-03-21 株式会社ナリス化粧品 Elastase inhibitor
WO2003002134A1 (en) 2001-06-27 2003-01-09 Unigen Pharmaceuticals, Inc. Method for generating, screening and dereplicating natural product libraries for the discovery of therapeutic agents
US6685971B2 (en) 2001-06-28 2004-02-03 Rongxiang Xu Method and composition for repairing and promoting regeneration of mucosal tissue in the gastrointestinal tract
DE10133203A1 (en) 2001-07-07 2003-01-16 Beiersdorf Ag Topical compositions containing catechins and/or their gallate esters, useful e.g. for treating or preventing dry skin or inflammatory conditions of the skin, e.g. eczema, polymorphic light dermatosis or psoriasis
CN1395383A (en) 2001-07-10 2003-02-05 颜森辉 Intelligent all-bearing expert management system
DE10139793A1 (en) 2001-08-14 2003-02-27 Beiersdorf Ag Use of wogonin for the production of cosmetic or dermatological preparations for the prophylaxis and treatment of inflammatory skin conditions and / or for skin protection in the case of sensitive, dry skin
US7338971B2 (en) 2001-08-30 2008-03-04 El-Naggar Mawaheb M Treatment of inflammatory, cancer, and thrombosis disorders
KR100486763B1 (en) 2001-09-07 2005-05-03 학교법인고려중앙학원 Extracts of Phyllostachys edulis leaf having antioxidant activity and the process for preparation thereof
JP2003081746A (en) 2001-09-12 2003-03-19 Pola Chem Ind Inc Extension inhibitor of dendrite of melanocyte and cosmetic containing the same
US6740343B2 (en) 2001-09-17 2004-05-25 Phytos, Inc. Standardized extracts of Scutellaria lateriflora
US20040185124A1 (en) 2002-10-24 2004-09-23 Hiromichi Hayashi Health food and antitumor agent
US20040057908A1 (en) 2001-12-13 2004-03-25 Bowen William H. Oral compositions and use thereof
US20030125264A1 (en) 2001-12-29 2003-07-03 Kimberly-Clark Worldwide, Inc. Methods For Treating Wounds
JP2003212786A (en) 2002-01-16 2003-07-30 Univ Nihon Skin care medicament with bamboo extract component as active ingredient
JP2003212771A (en) 2002-01-23 2003-07-30 Taiyo Kagaku Co Ltd Anti-neissria bacterium composition
US20030166583A1 (en) 2002-02-22 2003-09-04 Oliver Yoa-Pu Hu Dermal cytochrome P450 1A inhibitors and enhancers
US20050096281A1 (en) 2002-03-01 2005-05-05 Unigen Pharmaceuticals, Inc. Formulation of a mixture of Free-B-Ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
US7972632B2 (en) 2003-02-28 2011-07-05 Unigen Pharmaceuticals, Inc. Identification of Free-B-Ring flavonoids as potent COX-2 inhibitors
US20030165588A1 (en) 2002-03-01 2003-09-04 Unigen Pharmaceuticals, Inc. Identification of free-B-ring flavonoids as potent COX-2 inhibitors
US7108868B2 (en) 2002-03-22 2006-09-19 Unigen Pharmaceuticals, Inc. Isolation of a dual cox-2 and 5-lipoxygenase inhibitor from acacia
US7615239B2 (en) 2002-04-15 2009-11-10 Tetsuo Santo Tea for treating dermatitis comprising herbal extracts
US8945518B2 (en) 2002-04-30 2015-02-03 Unigen, Inc. Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions
EP2108370A1 (en) 2002-04-30 2009-10-14 Unigen Pharmaceuticals, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent
US8034387B2 (en) 2002-04-30 2011-10-11 Unigen, Inc. Formulation of a mixture of free-B-ring flavonoids and flavans for use in the prevention and treatment of cognitive decline and age-related memory impairments
CN1511549A (en) 2002-12-27 2004-07-14 张小丽 Composition containing scutellaria root for anti-tumor, anti-inflammation and tumor preventing medicine
JP2004244385A (en) 2003-02-14 2004-09-02 Pigeon Corp Mouth wash for infant having anticarious activity
WO2004075844A2 (en) 2003-02-26 2004-09-10 Unigen Pharmaceuticals, Inc. Formulation for use in the prevention and treatment of carbohydrate induced diseases and conditions
BRPI0408814A (en) 2003-03-27 2006-04-04 Unigen Inc pharmaceutical composition and food for health care
BRPI0409179A (en) 2003-04-04 2006-05-02 Unigen Pharmaceuticals Inc formulation of dual cyclooxygenase (cox) and lipoxygenase (lox) inhibitors for mammalian skin care
US7225870B2 (en) 2003-05-01 2007-06-05 Weatherford/Lamb, Inc. Hydraulic tools for setting liner top packers and method for cementing liners
CN1266144C (en) 2003-09-01 2006-07-26 上海凯曼生物科技有限公司 Compound of flavonoid as well as application and dosage form of extract product of the compound
EP1684737A4 (en) * 2003-11-07 2009-11-11 Oaky Natural Co Ltd Pharmaceutical composition containing guaiacol derivatives and syringol derivatives extracted from natural plant vinegar
KR100465113B1 (en) 2004-01-15 2005-01-14 주식회사 유니젠 Composition comprising an extract of Bambusoideae plant or tricin isolated therefrom
KR100522579B1 (en) 2004-04-30 2005-10-19 (주) 한약마을 Pharmaceutical composition comprising the extracts of scutellaria root and schizandra fruit mixture thereof having an effect of restraint stress
KR100720971B1 (en) 2004-06-11 2007-05-22 주식회사 유니젠 Composition having Bamboo or Bamboo extract for androgen agonist
US20060008749A1 (en) * 2004-07-08 2006-01-12 Frank Sobel Method for manufacturing of a mask blank for EUV photolithography and mask blank
KR100545304B1 (en) 2004-09-01 2006-05-08 주식회사 유니젠 Composition comprising uncaria genus plant having uncaria gambir, or scutellaria radix and/or green tea extract mixture for suppressing cyclooxygenase or 5-lipoxygenase
US20060140881A1 (en) 2004-12-22 2006-06-29 Guofeng Xu Oral care compositions containing flavonoids and flavans
US8895084B2 (en) 2004-12-23 2014-11-25 Colgate-Palmolive Company Oral care composition containing extract of unoxidized Camellia
CN101175406B (en) 2005-03-10 2012-11-21 尤尼根公司 Formulation of a mixture of free-B-ring flavonoids and flavans as a therapeutic agent
KR100720973B1 (en) 2005-03-18 2007-05-22 주식회사 유니젠 Composition comprising isoorientin for suppressing histamine
CN1686187A (en) 2005-03-23 2005-10-26 贵阳高新瑞得科技开发有限公司 Infantile lung clearing phlegm transforming effervescent granules and its making method
KR100761248B1 (en) 2006-10-12 2007-10-04 주식회사 유니젠 Composition for treating atopic dermatitis comprising extracts of bamboo and scutellaria
US9136202B2 (en) 2012-04-17 2015-09-15 Qualcomm Incorporated Enhanced package thermal management using external and internal capacitive thermal material
US10447702B2 (en) 2017-03-20 2019-10-15 Screening Room Media, Inc. Digital credential tiers

Patent Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH03240725A (en) * 1990-02-15 1991-10-28 Senjiyu Seiyaku Kk Maillard reaction inhibitor
US6093403A (en) * 1997-08-01 2000-07-25 Phytocell Research, Inc. Sugar imbalance and diabetes treating herbal formulation
US5886029A (en) * 1997-09-05 1999-03-23 Dhaliwal; Kirpal S. Method and composition for treatment of diabetes
EP0956867A1 (en) * 1998-05-12 1999-11-17 Franz-Peter Dr. Liebel Use of flavonoid glycosides, tanning agents and microorganisms for the therapy and prophylaxis of diabetes mellitus
JP2002053484A (en) * 2000-08-07 2002-02-19 Asahi Breweries Ltd Lipase inhibitor, and food and drink containing the same

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8945518B2 (en) 2002-04-30 2015-02-03 Unigen, Inc. Formulation of dual eicosanoid system and cytokine system inhibitors for use in the prevention and treatment of oral diseases and conditions

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