WO2003099246A1 - Liquid tooth whitening composition - Google Patents
Liquid tooth whitening composition Download PDFInfo
- Publication number
- WO2003099246A1 WO2003099246A1 PCT/US2003/016348 US0316348W WO03099246A1 WO 2003099246 A1 WO2003099246 A1 WO 2003099246A1 US 0316348 W US0316348 W US 0316348W WO 03099246 A1 WO03099246 A1 WO 03099246A1
- Authority
- WO
- WIPO (PCT)
- Prior art keywords
- composition
- teeth
- peroxide
- weight
- present
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/38—Percompounds, e.g. peracids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/19—Cosmetics or similar toiletry preparations characterised by the composition containing inorganic ingredients
- A61K8/22—Peroxides; Oxygen; Ozone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/33—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing oxygen
- A61K8/34—Alcohols
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8147—Homopolymers or copolymers of acids; Metal or ammonium salts thereof, e.g. crotonic acid, (meth)acrylic acid; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/81—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions involving only carbon-to-carbon unsaturated bonds
- A61K8/8141—Compositions of homopolymers or copolymers of compounds having one or more unsaturated aliphatic radicals, each having only one carbon-to-carbon double bond, and at least one being terminated by only one carboxyl radical, or of salts, anhydrides, esters, amides, imides or nitriles thereof; Compositions of derivatives of such polymers
- A61K8/8152—Homopolymers or copolymers of esters, e.g. (meth)acrylic acid esters; Compositions of derivatives of such polymers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/84—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds obtained by reactions otherwise than those involving only carbon-carbon unsaturated bonds
- A61K8/86—Polyethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q11/00—Preparations for care of the teeth, of the oral cavity or of dentures; Dentifrices, e.g. toothpastes; Mouth rinses
Definitions
- This invention relates in general to tooth whitening liquids and more particularly to a stable, aqueous peroxide containing liquid whitening product useful for whitening tooth enamel.
- a tooth is comprised of an inner dentin layer and an outer hard enamel layer that is the protective layer of the tooth.
- the enamel layer of a tooth is naturally an opaque white or slightly off-white color. It is the enamel layer that can become stained or discolored.
- the enamel layer of a tooth is composed of hydroxyapatite mineral crystals that create a somewhat porous surface. These hydroxyapatite crystals form microscopic hexagonal rods or prisms that make up the enamel surface. As a result, the surface of the enamel layer presents microscopic spaces or pores between the prisms. It is believed that this porous nature of the enamel layer is what allows staining agents and discoloring substances to permeate the enamel and discolor the tooth. These remaining substances can occupy the microscopic spaces and eventually alter the color of the tooth.
- a tooth whitening product that is to be used at home or in private by the consumer be safe and easy to use and be stable and retain its whitening efficacy during its storage on retail store shelves as well as over the period of use by the consumer.
- Products and substances that are presently available to whiten teeth include a variety of different ingredients, but the primary active ingredient is a peroxide agent formulated into a liquid, solution, paste or gel. These products upon storage lose their whitening efficacy over time.
- a further limitation of commonly used aqueous peroxide solutions is their brief period of efficacy when applied to the teeth in the oral cavity.
- saliva contains high concentrations of the enzyme catalase, which on contact, rapidly decomposes the peroxide into gaseous oxygen and water and so that there is only transitory contact of the peroxide whitening agent with the teeth.
- a liquid dental whitening composition containing a peroxide whitening constituent dispersed in an aqueous liquid vehicle in which is dispersed a film forming component, the liquid composition rapidly drying when applied to the tooth surfaces to form in situ a gel-like film containing the peroxide whitening agent.
- an aqueous tooth whitening liquid having enhanced stability and whitening efficacy, the liquid " being comprised of an aqueous vehicle containing a film forming combination of an ethylene oxide linear homopolymer, a Carbomer and a peroxide. whitening agent, the pH of the composition being maintained at an acidic level.
- the aqueous liquid of the present invention is a portable oral care tooth whitener that can be conveniently painted onto the tooth surface.
- the applied liquid whitening composition rapidly dries to produce, in situ, an adherent film of a thick liquid gel that has the capacity to release the peroxide whitening agent over an extended period of time.
- the film adheres to the tooth surface whereby the released peroxide source then whitens the teeth to which the film is applied, the film being sufficiently adherent to counteract the tooth flushing action of saliva generated in the oral cavity.
- the adjustment and maintenance of the composition pH to acid levels provides a peroxide source that is stable to decomposition on storage.
- the vehicle used to prepare the liquid whitening composition of the present invention includes a non-toxic volatile monohydric alcohol or any suitable mixture thereof.
- the presence of the volatile monohydric alcohol imparts a rapid drying property to the applied liquid whitening composition and is present in the composition at a concentration of about 10 to about 50% by weight and preferably about 25 to about 40% by weight.
- Water is included in the vehicle of the composition and about 15 to about 35% by weight of the composition and preferably about 20 to about 30% by weight.
- the proportion of vehicle used to prepare the liquid composition of the present invention is generally within the range of about 40 to about 80% by weight of the invention and preferably about 50 to about 70% by weight of the composition.
- a humectant such as sorbitol, glycerin or propylene glycol is present in the vehicle of the present invention at a concentration of about 2 to about 15% by weight and preferably about 3 to about 8 by weight.
- poly(ethylene oxides) useful in the practice of the present invention include PEG 2M, 5M, 7M, 14M, 23M, 45M and 90M commercially available from Union Carbide, Danbury, Connecticut, ranging in molecular weight from 100,000 to 4 million.
- a poly(ethylene oxide) preferred for use in the practice of the present invention is a poly(ethylene oxide) having a molecular weight of about 100,000.
- Such poly(ethylene oxide) or PEG 2M is a nonionic polymer of ethylene oxide having an average molecular weight of 100,000 and has the general formula:
- n represents the number of repeating CH2CH2O groups.
- Carbomers useful in the practice of the present invention include carboxymethylene polymers such as acrylic acid polymers, and acrylic acid copolymers.
- Carboxypolymethylene is a slightly acidic vinyl polymer with active carboxyl groups.
- a carboxypolymethylene preferred for use in the practice of the present invention is a water dispersible copolymer of acrylic acid cross-linked with approximately 0.75% to approximately 1.5% polyallyl sucrose that is sold under the trade designation Carbopol 934, 974 by B.F. Goodrich.
- the Carbopol product is present in the liquid whitening composition of the present invention at a concentration of about 0.25 to about 1.5% by weight and preferably about 0.5 to about 1.0% by weight.
- Peroxide compounds which may be used as whitening agents in the practice of the present invention include hydrogen peroxide, urea peroxide and percarbonate salts such as sodium percarbonate. Most preferred is urea peroxide.
- the peroxide constituent is present in the liquid whitening compositions of the present invention at a concentration of about 5 to about 30% by weight and preferably about 10 to about 25% by weight.
- the Carbomer of the Carbopol type behaves like a liquid gel rather than a solid gel so that the Carbomer in combination with the ⁇ oly(ethylene oxide) constituent provides thickness to the liquid product while maintaining a consistency enabling the product to be painted on the tooth surface with a soft applicator brush.
- the liquid whitening composition of the present invention may also contain a flavoring agent. Flavoring agents that are used in the practice of the present invention include essential oils as well as various flavoring aldehydes, esters, alcohols, and similar materials.
- the flavoring agent is incorporated in the whitening liquid composition of the present invention at a concentration of about 0.1 to about 2% by weight and preferably about 0.1 to about 0.5% by weight.
- the liquid whitening composition of the present invention is initially prepared in the form of a liquid varnish and applied as such to the users teeth as by painting the teeth with a soft applicator brush. After application by the user, the alcohol and water vehicle constituents rapidly evaporate to leave a film or coating of a thick liquid gel on the teeth to which the varnish has been applied.
- the deposited film is comprised of the ⁇ oly(ethylene oxide) constituent, the Carbomer and constituent and the peroxide whitening agent or agents.
- the presence of the poly(ethylene oxide) and Carbomer constituent combination permits a slow release of the peroxide agent or agents to the applied tooth site, providing prolonged whitening treatment of the site.
- the deposited film of iiquid gel contains no ingredients imparting thereto an unacceptable taste or texture, rendering it unpleasant to the user and adheres strongly to tooth enamel.
- the composition dries in a relatively short time period, for example, 20 to 60 seconds to yield a strongly adherent, clear or tooth-colored film which is effectively invisible while in place.
- the film gel is sufficiently strong and adherent enough to remain on the teeth for a period of time, for example 10 to 30 minutes to effect a whitening result and will resist the forces commonly applied by the lips and tongue. While the film is in place, the user is to refrain from mastication.
- the film can be removed as and when required, at will, by an employment of standard oral hygiene procedures such as brushing or by rinsing with an alcoholic mouthwash. While in place the film releases agents contained therein at a slow, relatively constant rate and in concentration sufficient effectively to effect stain removal from the teeth.
- the aqueous liquid whitening compositions of the present invention are prepared by adding and mixing the ingredients of the composition in a suitable vessel such as a stainless steel tank provided with a mixer.
- the ingredients are advantageously added to the mixer in the following order: water, Carbomer, alcohol, humectant, poly(ethylene oxide), and peroxide compound and any desired flavoring.
- the ingredients are then mixed to form a homogeneous dispersion/solution.
- the pH of the composition is adjusted to a pH of between about 3.5 and about 5.5 and preferably about 4.0 to about 4.5 with an orally acceptable acid such as phosphoric acid, lactic acid and malic acid or mixtures thereof which is generally added to the whitening liquid at a concentration of 0.05 to 2% by weight and preferably about 0.1 to about 1% by weight.
- the pH is buffered with a buffering agent such as sodium phosphate and sodium citrate and to maintain the acid value pH selected for the preparation of the liquid whitening composition.
- the present invention is illustrated by the following example but is not to be limited thereby.
- a whitening liquid having a pH of 4.0 was prepared having the following ingredients:
- the shelf stability of the whitening liquid packaged in plastic bottles was determined by the percent urea peroxide recovered from the whitening liquid after a 4 to 12 week exposure to temperatures of 77°F and 105°F. Peroxide recovery analysis was performed using lodometric Titration. The stability results are recorded in Table I below.
- Intrinsic staining that is, staining trapped inside the tooth enamel was measured as shade guide improvement using Vita LuminTM Vacuum Farbskala Shade Guides, a product of Nita Zahnfabrik, of Badsackinger, Germany which has 16 shades. The intrinsic staining results are recorded in Table DI below.
- the comparative composition was Composition C2, a commercially available whitening toothpaste.
- the teeth of all the subjects were professionally cleaned prior to initiation of the study.
- the study was conducted for a three week period. The results are recorded in Table IV below.
Abstract
Description
Claims
Priority Applications (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
BR0311261-6A BR0311261A (en) | 2002-05-24 | 2003-05-23 | Teeth Whitening Aqueous Liquid Composition and Method for Teeth Whitening |
EP03736696A EP1507506A1 (en) | 2002-05-24 | 2003-05-23 | Liquid tooth whitening composition |
AU2003237228A AU2003237228B2 (en) | 2002-05-24 | 2003-05-23 | Liquid tooth whitening composition |
CA002487078A CA2487078A1 (en) | 2002-05-24 | 2003-05-23 | Liquid tooth whitening composition |
MXPA04011571A MXPA04011571A (en) | 2002-05-24 | 2003-05-23 | Liquid tooth whitening composition. |
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US10/155,496 US6770266B2 (en) | 2002-05-24 | 2002-05-24 | Liquid tooth whitening composition |
US10/155,496 | 2002-05-24 |
Publications (1)
Publication Number | Publication Date |
---|---|
WO2003099246A1 true WO2003099246A1 (en) | 2003-12-04 |
Family
ID=29549079
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
PCT/US2003/016348 WO2003099246A1 (en) | 2002-05-24 | 2003-05-23 | Liquid tooth whitening composition |
Country Status (14)
Country | Link |
---|---|
US (2) | US6770266B2 (en) |
EP (1) | EP1507506A1 (en) |
CN (1) | CN100374100C (en) |
AR (1) | AR040101A1 (en) |
AU (1) | AU2003237228B2 (en) |
BR (1) | BR0311261A (en) |
CA (1) | CA2487078A1 (en) |
MX (1) | MXPA04011571A (en) |
MY (1) | MY137821A (en) |
PL (1) | PL374613A1 (en) |
RU (1) | RU2286762C2 (en) |
TW (1) | TW200407170A (en) |
WO (1) | WO2003099246A1 (en) |
ZA (1) | ZA200409448B (en) |
Cited By (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3329900A4 (en) * | 2015-07-31 | 2019-03-27 | GC Corporation | Tooth whitening composition |
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US7700295B2 (en) * | 2000-12-28 | 2010-04-20 | Mds Sciex | Elemental analysis of tagged biologically active materials |
US20030232310A1 (en) * | 2002-06-14 | 2003-12-18 | Matthews Alan B. | Dental whitening |
US8524200B2 (en) | 2002-09-11 | 2013-09-03 | The Procter & Gamble Company | Tooth whitening products |
US20050069503A1 (en) * | 2003-03-10 | 2005-03-31 | Larsen Robert K. | Tooth whitening mouthwashes and methods for making and using them |
GB2409976A (en) * | 2004-01-19 | 2005-07-20 | Glaxo Group Ltd | Tooth whitening composition |
GB2409975A (en) * | 2004-01-19 | 2005-07-20 | Glaxo Group Ltd | Tooth whitening composition |
US20080193392A1 (en) * | 2005-03-18 | 2008-08-14 | Lg Household & Health Care Ltd. | Tooth Whitener |
US20060280700A1 (en) * | 2005-06-08 | 2006-12-14 | Isler Stuart L | Oral hygiene system to fight the effects of aging on the mouth, gums, and teeth |
US9072672B2 (en) * | 2005-06-28 | 2015-07-07 | Colgate-Palmolive Company | Compositions and methods for altering the color of teeth |
US8137658B2 (en) | 2005-06-28 | 2012-03-20 | Isp Investments Inc. | Tooth whitening compositions |
MX2008000556A (en) | 2005-07-12 | 2008-03-10 | Colgate Palmolive Co | Oral care implement having reservoir for dispensing active agent. |
US8034323B2 (en) * | 2005-12-21 | 2011-10-11 | Avon Products, Inc. | Cosmetic compositions having in-situ silicone condensation cross-linking |
CN101340885A (en) | 2005-12-21 | 2009-01-07 | 高露洁-棕榄公司 | Cleaning and/or polishing compositions and methods for use thereof |
US7750106B2 (en) * | 2005-12-21 | 2010-07-06 | Avon Products, Inc. | Cosmetic compositions having in-situ hydrosilylation cross-linking |
US8101368B2 (en) * | 2006-02-13 | 2012-01-24 | Dvs Sciences Inc. | Quantitation of cellular DNA and cell numbers using element labeling |
US9682256B2 (en) | 2006-07-14 | 2017-06-20 | Colgate-Palmolive Company | Methods of making compositions comprising films |
US8517728B2 (en) | 2007-01-24 | 2013-08-27 | Colgate-Palmolive Company | Oral care implement having fluid delivery system |
US8075216B2 (en) | 2007-01-25 | 2011-12-13 | Colgate-Palmolive Company | Oral care implement housing an oral care agent |
EP2197555B1 (en) | 2007-05-07 | 2015-12-02 | Koninklijke Philips N.V. | A method for cleaning dental plaque from teeth using an adherent peelable gel |
SG172205A1 (en) | 2008-12-23 | 2011-07-28 | Boc Group Ltd | Cosmetic teeth whitening |
MX368188B (en) | 2010-02-26 | 2019-09-23 | Colgate Palmolive Co | Fluid delivery system for an oral care implement. |
US8398326B2 (en) | 2010-03-04 | 2013-03-19 | Colgate-Palmolive Company | Fluid dispensing oral care implement |
MX2012012869A (en) | 2010-05-07 | 2012-11-29 | Guillette Company | Toothbrush. |
CA2824663C (en) | 2010-12-30 | 2020-04-14 | Dentovations Inc. | Method and device for whitening teeth using sonochemistry |
US9877813B2 (en) * | 2010-12-30 | 2018-01-30 | Frederick Ralph Guy | Dental device material preparation |
US11571584B2 (en) | 2010-12-30 | 2023-02-07 | Frederick R. Guy | Tooth and bone restoration via plasma deposition |
US10384069B2 (en) | 2013-01-22 | 2019-08-20 | Frederick R. Guy | Tooth and bone restoration via plasma deposition |
WO2012105961A1 (en) | 2011-02-01 | 2012-08-09 | Colgate-Palmolive Company | Oral care implement with fluid applicator and method of assembling the same |
KR20130128009A (en) | 2011-03-09 | 2013-11-25 | 콜게이트-파아므올리브캄파니 | Interdental cleaning device |
MX338787B (en) | 2011-03-28 | 2016-05-02 | Colgate Palmolive Co | Toothbrush having oral care fluid delivery. |
EP2755595B1 (en) | 2011-09-12 | 2021-04-14 | Mavrik Dental Systems Ltd. | Devices for the whitening of teeth |
US9554641B2 (en) | 2012-10-26 | 2017-01-31 | Colgate-Palmolive Company | Oral care implement |
WO2015038400A1 (en) | 2013-09-11 | 2015-03-19 | 3M Innovative Properties Company | Oral compositions |
US10064802B2 (en) | 2013-09-11 | 2018-09-04 | 3M Innovative Properties Company | Oral compositions, dental structures and methods of delivering oral compositions |
CN104013536B (en) * | 2014-06-17 | 2016-07-06 | 广州薇美姿实业有限公司 | A kind of film-forming products for beautifying tooth |
AU2017379750B2 (en) | 2016-12-20 | 2020-06-25 | Colgate-Palmolive Company | Personal care implement with fluid delivery system |
CN108261349A (en) * | 2018-03-06 | 2018-07-10 | 山东美齿汇医疗科技有限公司 | Tooth whitening liquid |
CN108451793B (en) * | 2018-06-28 | 2022-02-15 | 吉林省登泰克牙科材料有限公司 | Tooth cold light whitening composition and application thereof |
US20240000222A1 (en) | 2020-11-17 | 2024-01-04 | Colgate-Palmolive Company | Oral Care Implement with Fluid Dispensing System |
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US6221341B1 (en) * | 1997-11-19 | 2001-04-24 | Oraceutical Llc | Tooth whitening compositions |
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US6365134B1 (en) * | 1999-07-07 | 2002-04-02 | Scientific Pharmaceuticals, Inc. | Process and composition for high efficacy teeth whitening |
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-
2002
- 2002-05-24 US US10/155,496 patent/US6770266B2/en not_active Expired - Lifetime
-
2003
- 2003-05-22 MY MYPI20031900A patent/MY137821A/en unknown
- 2003-05-23 AU AU2003237228A patent/AU2003237228B2/en not_active Ceased
- 2003-05-23 RU RU2004137809/15A patent/RU2286762C2/en not_active IP Right Cessation
- 2003-05-23 CN CNB038118483A patent/CN100374100C/en not_active Expired - Fee Related
- 2003-05-23 CA CA002487078A patent/CA2487078A1/en not_active Abandoned
- 2003-05-23 AR ARP030101824A patent/AR040101A1/en unknown
- 2003-05-23 MX MXPA04011571A patent/MXPA04011571A/en active IP Right Grant
- 2003-05-23 EP EP03736696A patent/EP1507506A1/en not_active Withdrawn
- 2003-05-23 TW TW092113918A patent/TW200407170A/en unknown
- 2003-05-23 PL PL03374613A patent/PL374613A1/en unknown
- 2003-05-23 WO PCT/US2003/016348 patent/WO2003099246A1/en not_active Application Discontinuation
- 2003-05-23 BR BR0311261-6A patent/BR0311261A/en not_active IP Right Cessation
-
2004
- 2004-03-17 US US10/801,312 patent/US20040175333A1/en not_active Abandoned
- 2004-11-23 ZA ZA200409448A patent/ZA200409448B/en unknown
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US4895721A (en) * | 1988-01-22 | 1990-01-23 | Carter-Wallace Inc. | Peroxide gel dentifrice compositions |
US6306370B1 (en) * | 1997-05-30 | 2001-10-23 | Ultradent Products, Inc. | Compositions and methods for whitening and desensitizing teeth |
US6221341B1 (en) * | 1997-11-19 | 2001-04-24 | Oraceutical Llc | Tooth whitening compositions |
US6365134B1 (en) * | 1999-07-07 | 2002-04-02 | Scientific Pharmaceuticals, Inc. | Process and composition for high efficacy teeth whitening |
US6447757B1 (en) * | 2000-11-08 | 2002-09-10 | Scientific Pharmaceuticals, Inc. | Teeth whitening composition with increased bleaching efficiency and storage stability |
Cited By (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3329900A4 (en) * | 2015-07-31 | 2019-03-27 | GC Corporation | Tooth whitening composition |
US10874596B2 (en) | 2015-07-31 | 2020-12-29 | Gc Corporation | Tooth whitening composition |
Also Published As
Publication number | Publication date |
---|---|
AR040101A1 (en) | 2005-03-16 |
CN100374100C (en) | 2008-03-12 |
CN1671350A (en) | 2005-09-21 |
US20040175333A1 (en) | 2004-09-09 |
US20030219390A1 (en) | 2003-11-27 |
TW200407170A (en) | 2004-05-16 |
RU2286762C2 (en) | 2006-11-10 |
US6770266B2 (en) | 2004-08-03 |
MY137821A (en) | 2009-03-31 |
ZA200409448B (en) | 2006-06-28 |
RU2004137809A (en) | 2005-06-27 |
AU2003237228A1 (en) | 2003-12-12 |
EP1507506A1 (en) | 2005-02-23 |
AU2003237228B2 (en) | 2008-01-10 |
BR0311261A (en) | 2005-03-15 |
CA2487078A1 (en) | 2003-12-04 |
MXPA04011571A (en) | 2005-03-07 |
PL374613A1 (en) | 2005-10-31 |
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