WO2004071500A1 - Cosmetic rejuvenating and healing product, method of its manufacture and uses thereof - Google Patents

Cosmetic rejuvenating and healing product, method of its manufacture and uses thereof Download PDF

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Publication number
WO2004071500A1
WO2004071500A1 PCT/US2003/030706 US0330706W WO2004071500A1 WO 2004071500 A1 WO2004071500 A1 WO 2004071500A1 US 0330706 W US0330706 W US 0330706W WO 2004071500 A1 WO2004071500 A1 WO 2004071500A1
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Prior art keywords
volume
vitamin
source
formulation
cosmetic
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Application number
PCT/US2003/030706
Other languages
French (fr)
Inventor
Myong Hun Chong
Original Assignee
Hanna Isul Skin Therapy, Inc.
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Priority to AU2003277046A priority Critical patent/AU2003277046A1/en
Publication of WO2004071500A1 publication Critical patent/WO2004071500A1/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/045Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/07Retinol compounds, e.g. vitamin A
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/40Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
    • A61K8/42Amides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/671Vitamin A; Derivatives thereof, e.g. ester of vitamin A acid, ester of retinol, retinol, retinal
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/676Ascorbic acid, i.e. vitamin C
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/67Vitamins
    • A61K8/678Tocopherol, i.e. vitamin E
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9789Magnoliopsida [dicotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/96Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
    • A61K8/97Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
    • A61K8/9783Angiosperms [Magnoliophyta]
    • A61K8/9794Liliopsida [monocotyledons]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q19/00Preparations for care of the skin
    • A61Q19/08Anti-ageing preparations
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • A61K2800/75Anti-irritant
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Definitions

  • the present invention relates to a cosmetic composition for rejuvenating the appearance of skin with reduced or minimal potential for skin irritation, preferably in the form of a lotion or creme, which includes as a major component aloe vera as well as Vitamins A,B,C,D and E.
  • creams or ointments are designed to deliver an active component only to the epidermal surface of the skin or, at best, to provide limited delivery through the surface skin layers.
  • Most cosmetic formulations currently available utilize an intimate dispersion or solution of the active components or components in a suitable oily medium or a water/oil or oil/water emulsion. Thus the formulation is presented to the epidermal surface in a form likely to penetrate only into the outer layer of the epidermis.
  • the present invention is a cosmetic composition for rejuvenating the appearance of skin with reduced or minimal potential for skin irritation, preferably in the form of a lotion or cream, which includes as a major component aloe vera as well as Vitamins A, B, C, D and E.
  • the cosmetic composition contains greater than about 50% aloe vera and as well as each of the vitamins A, B, C, D and E as an essential component.
  • the major components of the composition are non-oily, natural ingredients and yet the formulation of the invention has an extended shelf life. The non-oily nature of the formulation allows the active ingredients to penetrate the human epidermis to a greater relative depth than prior oil-based formulations.
  • the cosmetic formulations of the invention aid in relieving skin irritation, acne, swelling, bruising, infection, burns, stings and rashes of the epidermis.
  • the cosmetic formulations are also beneficial in treating the deleterious effects of glycolic or chemical peels, and relieve itching after laser surgery or face lift surgery immediately upon contact. While other products cleanse and moisturize at the surface level, the formulations of the present invention restore, balance and hydrate the human epidermis at a deeper level, returning it to its normal healthy state.
  • the cosmetic formulations of the invention utilize pure botanical essences and vitamins to provide gentle, fragrant and soothing compositions which aid the skin's ability to heal itself.
  • the formulations of the invention nurture and nourish the skin so that within a short period of time the skin appears younger, healthier, more firm and glowing.
  • Applicant has combined each of the vitamins A, B, C, D and E as an essential component within a natural ingredient based recovery ointment which has an extended shelf life.
  • the formulations of the invention contain a natural base ingredient which is combined with other ingredients to achieve a synergistic result.
  • the base ingredient is aloe vera extract.
  • Aloe vera is a well known extract from the aloe plant and occurs naturally in nature.
  • the aloe leaf consists of three primary sections: the rind (photosynthesis) with sap contained in the pericyclic transport tubules (xylem and phloem), the mucilage (container) layer and the parenchyma or gel fillet (storage) layer.
  • the beneficial properties of the plant extract are the result of the synergistic actions of at least 75 known ingredients, including polysaccharides, steroids, organic acids, enzymes, antibiotic agents, amino acids and minerals.
  • Glucomannan one special complex polysaccharide composed largely of the sugar mannose, interacts with special cell-surface receptors on those cells which repair damaged tissues, called fibroblasts, stimulating them, activating their faster growth and replication. Plant hormones in aloe, called gibberellins, also accelerate healing by cell replication.
  • the aloe vera component of Applicant's formulation is present in the range from about 50-75 % by volume, preferably in an amount greater than about 50% by volume, and most preferably about 60% by volume, based upon the total volume of the cosmetic formulation.
  • Applicant's cosmetic formulations present the positive healing properties of the aloe extract in combination with a synergistic active ingredient formulation which allows the active ingredients to penetrate more deeply into the epidermis to provide a deeper, longer lasting healing effect.
  • the additional components of the formulation will be discussed in turn below.
  • Deionized water is purified water having almost all solids removed by an ion- exchange process and is widely used in the laboratory environment. It is present in the range from about 5 to 25%, most preferably about 1 5.5% by volume, based upon the total volume of the cosmetic formulation.
  • Cetearyl alcohol also known as cetostearyl alcohol, and polysorbate 60 (polyoxyethylene sorbitan monostearate) are emollient and emulsion stabilizers used in many cosmetic preparations.
  • This component of the formulation of the invention is preferably present in the range from about 0.1 to 5% by volume, most preferably about 1 % by volume.
  • Isopropyl palmitate is a mixture of solid organic acids obtained from fats consisting chiefly of palmitic acid with varying amounts of stearic acid. It is used in various products as an emollient and texturizer. This component is present in the range from about 2 to 5%, most preferably about 3%.
  • Glycerine is a viscous, crystalline liquid formed when fat molecules split, forming free fatty acids and glycerine. It is commercially available from a number of sources and serves as a humectant. Glycerine is present in the range from about 1 to 5% by volume, most preferably about 3% by volume.
  • Cetyl alcohol is an emollient and emulsion stabilizer used in various cosmetic compositions and is present in the range from about 2 to 7% by volume, most preferably about 5% by volume.
  • Shea butter is a slightly ivory granulated butter consisting of mostly triglycerides, including a fair amount of linoleic acid, and unsaponifiables. It is present in the formulations of the invention in the range from about 1 to 5% by volume, most preferably about 2% by volume, based upon the total volume of the formulation.
  • the glyceryl stearate/PEG 100 Stearate are commercial emulsifiers present in the range from about 1 to 5%, most preferably about 3% by volume.
  • Cyclomethicone is a widely used silicone agent found in hair and skin care products and is present in the formulations of the invention in the range from about 0.5 to 5% by volume, preferably about 2% by volume.
  • phenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben and isobutylparaben components of the formulations of the invention are commercially available preservatives present in the range from about 0.5 to 3%, most preferably about 0.7% by volume.
  • the jojoba oil component of the formulations of the invention is an oil extracted from the bean-like seeds of the desert shrub, Simondsia Chinensis. It can be pressed into a golden, naturally liquid wax. As a lubricant, it has been used in the past as a substitute for camauba wax and beeswax. It is present in the formulations of the invention in the range from about 0.5 to 3%, most preferably about 1 % by volume.
  • avocado oil is extracted from the fruit of the tree, Persea americana. It is a vegetal oil used in moisturizers and facial creams. It is clear, light and non-tacky with quick penetration characteristics. It is present in the range from about 0.1 to 3% by volume, preferably about 0.5% by volume.
  • Lanolin oil is a yellowish-white fatty substance obtained from the wool of sheep.
  • This component is present in the range from about 0.1 to 3% by volume, preferably about 0.5 % by volume.
  • Hydrogenated Castor Oil C3H5(C18H35O3)3, is widely used for manufacturing cosmetics, shoeshines and other products as well as for making 1 2-hydroxy stearic acid. It is present in the range from about 01 . to 3%, most preferably about 0.5%.
  • Demethicone is another commercially available silicone agent used as an ointment base. It is present in the range from about 0.1 to 3% by volume, preferably about 1 % by volume.
  • Tocopheryl acetate is a source of Vitamin E. It has known antioxidant properties and is present in the range from about 0.1 to 2% by volume, preferably about 0.2% by volume.
  • Orange oil is used as a flavor or scent additive and contains enzymes which purify the skin in the formulations of the invention and is present in the range from about 0.1 to 2% by volume, preferably about 0.5% by volume.
  • Panthenol also known as dexpanthenol is a Vitamin B complex factor used in hair products and in emollients. It is present in the range from about 0.1 to 2% by volume, preferably about 0.2% by volume.
  • Retinyl palmitate is the ester of Vitamin A and palmitic acid. It is present in the range from about 0.1 to 1 % by volume, preferably about 0.2% by volume.
  • Cholecalciferol or ergocalciferol is a white, colorless crystal found in plants and years having Vitamin D activity. It is present in the range from about 0.05 to 0.5% by volume, preferably about 0.1 % by volume.
  • Ascorbyl palmitate is an anti-oxidant and source of Vitamin C and is present in the formulations of the invention in the range from about 0.05 to2% by volume, most preferably about 0.1 % by volume.
  • the cosmetic rejuvenating formulation of the invention comprises:
  • the formulations of the invention contain non-oily, natural ingredients that penetrate the epidermis to provide improved healing properties for skin irritations, acne, bruising and swelling as well as the inflammation caused from trauma to the skin following surgical procedures.
  • the formulations assist in burn healing and in the treatment of stings, rashes, eczema, psoriasis and heat rash.
  • the formulations of the invention have an extended shelf life of 3 years or more.
  • the unique combination of Vitamins A,B,C,D and E produces a synergistic effect in achieving the desired results mentioned above.

Abstract

A cosmetic composition is shown for rejuvenating the apparance of skin with reduced or minimal potential for skin irritation, in the form of a lotion or cream which includes as a major component aloe vera as well as vitamins A, B, C, D and E.

Description

COSMETIC REJUVENATING AND HEALING PRODUCT, METHOD OF ITS MANUFACTURE AND USES THEREOF
Description
Technical Field
The present invention relates to a cosmetic composition for rejuvenating the appearance of skin with reduced or minimal potential for skin irritation, preferably in the form of a lotion or creme, which includes as a major component aloe vera as well as Vitamins A,B,C,D and E.
Background Art
Conventional treatment of, or attempted prevention of, normal tissue damage caused by, for example, UV radiation of the sun, over-exfoliated, peeled and lasered skin tissue, and the like, is currently confined to the application of bland moisturizing creams designed only to minimize infection to the damaged site or to prevent itching and subsequent scratching by the affected individual. Such treatment can at best only offer symptomatic relief and a barrier to assist prevention of secondary infection at the affected site.
Additionally, conventional creams or ointments are designed to deliver an active component only to the epidermal surface of the skin or, at best, to provide limited delivery through the surface skin layers. Most cosmetic formulations currently available utilize an intimate dispersion or solution of the active components or components in a suitable oily medium or a water/oil or oil/water emulsion. Thus the formulation is presented to the epidermal surface in a form likely to penetrate only into the outer layer of the epidermis.
A need exits, therefore, for a cosmetic formulation which will treat all skin types deep beneath the surface layer of the epidermis to restore, balance and hydrate the skin, returning the skin to its normal, healthy level.
A need also exists for such a cosmetic formulation which exhibits a similar beneficial effect when applied to burns, stings, rashes, infections, acne and other skin irritations.
A need also exists for such a cosmetic formulation which relieves itching and other discomforts suffered after laser or face lift surgery and glycolic or chemical peels which acts swiftly to aid the healing process immediately upon contact.
A need exists for such a cosmetic formulation which contains non-oily, natural ingredients yet exhibits an extended shelf life without prematurely degrading.
A need also exists for such a formulation which contains a sun supplement to help protect the skin from damage from the harmful effects of the sun.
Disclosure of Invention
The present invention is a cosmetic composition for rejuvenating the appearance of skin with reduced or minimal potential for skin irritation, preferably in the form of a lotion or cream, which includes as a major component aloe vera as well as Vitamins A, B, C, D and E. Preferably, the cosmetic composition contains greater than about 50% aloe vera and as well as each of the vitamins A, B, C, D and E as an essential component. The major components of the composition are non-oily, natural ingredients and yet the formulation of the invention has an extended shelf life. The non-oily nature of the formulation allows the active ingredients to penetrate the human epidermis to a greater relative depth than prior oil-based formulations.
Additional objects, features and advantages will be apparent in the written description which follows.
Best Mode for Carrying Out the Invention
The cosmetic formulations of the invention aid in relieving skin irritation, acne, swelling, bruising, infection, burns, stings and rashes of the epidermis. The cosmetic formulations are also beneficial in treating the deleterious effects of glycolic or chemical peels, and relieve itching after laser surgery or face lift surgery immediately upon contact. While other products cleanse and moisturize at the surface level, the formulations of the present invention restore, balance and hydrate the human epidermis at a deeper level, returning it to its normal healthy state.
The cosmetic formulations of the invention utilize pure botanical essences and vitamins to provide gentle, fragrant and soothing compositions which aid the skin's ability to heal itself. The formulations of the invention nurture and nourish the skin so that within a short period of time the skin appears younger, healthier, more firm and glowing. For the first time, Applicant has combined each of the vitamins A, B, C, D and E as an essential component within a natural ingredient based recovery ointment which has an extended shelf life.
The formulations of the invention contain a natural base ingredient which is combined with other ingredients to achieve a synergistic result. The base ingredient is aloe vera extract.
Aloe vera is a well known extract from the aloe plant and occurs naturally in nature. The aloe leaf consists of three primary sections: the rind (photosynthesis) with sap contained in the pericyclic transport tubules (xylem and phloem), the mucilage (container) layer and the parenchyma or gel fillet (storage) layer. It is believed that the beneficial properties of the plant extract are the result of the synergistic actions of at least 75 known ingredients, including polysaccharides, steroids, organic acids, enzymes, antibiotic agents, amino acids and minerals. Glucomannan, one special complex polysaccharide composed largely of the sugar mannose, interacts with special cell-surface receptors on those cells which repair damaged tissues, called fibroblasts, stimulating them, activating their faster growth and replication. Plant hormones in aloe, called gibberellins, also accelerate healing by cell replication. Various other beneficial effects of the aloe vera plant extract are reported in the literature. The aloe vera component of Applicant's formulation is present in the range from about 50-75 % by volume, preferably in an amount greater than about 50% by volume, and most preferably about 60% by volume, based upon the total volume of the cosmetic formulation.
Applicant's cosmetic formulations present the positive healing properties of the aloe extract in combination with a synergistic active ingredient formulation which allows the active ingredients to penetrate more deeply into the epidermis to provide a deeper, longer lasting healing effect. The additional components of the formulation will be discussed in turn below.
Deionized water is purified water having almost all solids removed by an ion- exchange process and is widely used in the laboratory environment. It is present in the range from about 5 to 25%, most preferably about 1 5.5% by volume, based upon the total volume of the cosmetic formulation.
Cetearyl alcohol, also known as cetostearyl alcohol, and polysorbate 60 (polyoxyethylene sorbitan monostearate) are emollient and emulsion stabilizers used in many cosmetic preparations. This component of the formulation of the invention is preferably present in the range from about 0.1 to 5% by volume, most preferably about 1 % by volume.
Isopropyl palmitate is a mixture of solid organic acids obtained from fats consisting chiefly of palmitic acid with varying amounts of stearic acid. It is used in various products as an emollient and texturizer. This component is present in the range from about 2 to 5%, most preferably about 3%.
Glycerine is a viscous, crystalline liquid formed when fat molecules split, forming free fatty acids and glycerine. It is commercially available from a number of sources and serves as a humectant. Glycerine is present in the range from about 1 to 5% by volume, most preferably about 3% by volume.
Cetyl alcohol is an emollient and emulsion stabilizer used in various cosmetic compositions and is present in the range from about 2 to 7% by volume, most preferably about 5% by volume.
Shea butter is a slightly ivory granulated butter consisting of mostly triglycerides, including a fair amount of linoleic acid, and unsaponifiables. It is present in the formulations of the invention in the range from about 1 to 5% by volume, most preferably about 2% by volume, based upon the total volume of the formulation.
The glyceryl stearate/PEG 100 Stearate are commercial emulsifiers present in the range from about 1 to 5%, most preferably about 3% by volume.
Cyclomethicone is a widely used silicone agent found in hair and skin care products and is present in the formulations of the invention in the range from about 0.5 to 5% by volume, preferably about 2% by volume.
The phenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben and isobutylparaben components of the formulations of the invention are commercially available preservatives present in the range from about 0.5 to 3%, most preferably about 0.7% by volume.
The jojoba oil component of the formulations of the invention is an oil extracted from the bean-like seeds of the desert shrub, Simondsia Chinensis. It can be pressed into a golden, naturally liquid wax. As a lubricant, it has been used in the past as a substitute for camauba wax and beeswax. It is present in the formulations of the invention in the range from about 0.5 to 3%, most preferably about 1 % by volume.
Avocado oil is extracted from the fruit of the tree, Persea americana. It is a vegetal oil used in moisturizers and facial creams. It is clear, light and non-tacky with quick penetration characteristics. It is present in the range from about 0.1 to 3% by volume, preferably about 0.5% by volume.
Lanolin oil is a yellowish-white fatty substance obtained from the wool of sheep.
This component is present in the range from about 0.1 to 3% by volume, preferably about 0.5 % by volume.
Hydrogenated Castor Oil, C3H5(C18H35O3)3, is widely used for manufacturing cosmetics, shoeshines and other products as well as for making 1 2-hydroxy stearic acid. It is present in the range from about 01 . to 3%, most preferably about 0.5%.
Demethicone is another commercially available silicone agent used as an ointment base. It is present in the range from about 0.1 to 3% by volume, preferably about 1 % by volume.
Tocopheryl acetate is a source of Vitamin E. It has known antioxidant properties and is present in the range from about 0.1 to 2% by volume, preferably about 0.2% by volume.
Orange oil is used as a flavor or scent additive and contains enzymes which purify the skin in the formulations of the invention and is present in the range from about 0.1 to 2% by volume, preferably about 0.5% by volume. Panthenol, also known as dexpanthenol is a Vitamin B complex factor used in hair products and in emollients. It is present in the range from about 0.1 to 2% by volume, preferably about 0.2% by volume.
Retinyl palmitate is the ester of Vitamin A and palmitic acid. It is present in the range from about 0.1 to 1 % by volume, preferably about 0.2% by volume.
Cholecalciferol or ergocalciferol is a white, colorless crystal found in plants and years having Vitamin D activity. It is present in the range from about 0.05 to 0.5% by volume, preferably about 0.1 % by volume.
Ascorbyl palmitate is an anti-oxidant and source of Vitamin C and is present in the formulations of the invention in the range from about 0.05 to2% by volume, most preferably about 0.1 % by volume.
In a particularly preferred form, the cosmetic rejuvenating formulation of the invention comprises:
Figure imgf000009_0001
An invention has been provided with several advantages. The formulations of the invention contain non-oily, natural ingredients that penetrate the epidermis to provide improved healing properties for skin irritations, acne, bruising and swelling as well as the inflammation caused from trauma to the skin following surgical procedures. The formulations assist in burn healing and in the treatment of stings, rashes, eczema, psoriasis and heat rash. Despite the use of natural active ingredients, the formulations of the invention have an extended shelf life of 3 years or more. The unique combination of Vitamins A,B,C,D and E produces a synergistic effect in achieving the desired results mentioned above.
While the invention has been shown in only one of its forms, it is not thus limited but is susceptible to various changes and modifications without departing from the spirit thereof.

Claims

ClaimsWhat is claimed is:
1 . A cosmetic formulation comprising: a non-oily base comprising greater than about 50% by volume, based upon the total volume of the formulation, of aloe vera extract; from about 0.1 to 1 .0% by volume of tocopheryl acetate as a source of Vitamin E; from about 0.1 to 0.5% by volume of retinyl palmitate as a source of Vitamin A; from about 0.05 to 0.5% by volume of ascorbyl palmitate as a source of Vitamin C; from about 0.1 . to 2.0% panthenol as a source of Vitamin B; from about 0.05 to 0.5% cholercalciferol as a source of Vitamin D; the balance being emulsifier, emollients and preservatives.
2. The cosmetic formulation of claim 1 , further comprising: as additional ingredients, cetearyl alcohol, Polysorbate 60, isopropyl palmitate, glycerine, cetyl alcohol and shea butter.
3. The cosmetic formulation of claim 2, further including as additional ingredients: glyceryl stearate, PEG 1 00 Stearate, cyclomethicone, jojoba oil, avocado oil and lanolin oil.
4. The cosmetic formulation of claim 3, wherein the preservatives present in the formulation include phenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben and isobutylparaben.
5. The cosmetic formulation of claim 4, further comprising as additional ingredients: demethicone and orange oil.
6. A cosmetic formulation consisting essentially of: a non-oily base comprising approximately 60% by volume, based upon the total volume of the formulation, of aloe vera extract; from about 0.1 to 1 .0% by volume of tocopheryl acetate as a source of Vitamin E; from about 0.1 to 0.5% by volume of retinyl palmitate as a source of Vitamin A; from about 0.05 to 0.5% by volume of ascorbyl palmitate as a source of Vitamin C; from about 0.1 . to 2.0% panthenol as a source of Vitamin B; from about 0.05 to 0.5% cholercalciferol as a source of Vitamin D; the balance being emulsifier, emollients and preservatives.
7. The cosmetic formulation of claim 6, further comprising: as additional ingredients, cetearyl alcohol, Polysorbate 60, isopropyl palmitate, glycerine, cetyl alcohol and shea butter.
8. The cosmetic formulation of claim 7, further including as additional ingredients: glyceryl stearate, PEG 100 Stearate, cyclomethicone, jojoba oil, avocado oil and lanolin oil.
9. The cosmetic formulation of claim 8, wherein the preservatives present in the formulation include phenoxyethanol, methylparaben, ethylparaben, butylparaben, propylparaben and isobutylparaben.
1 0. The cosmetic formulation of claim 9, further comprising as additional ingredients: demethicone and orange oil.
1 1 . A cosmetic technique for rejuvenating the appearance of human epidermis with reduced or minimal potential for skin irritation, in the form of a cream which includes as a major component aloe vera as well as vitamins A,B,C,D and E, the technique comprising the steps of: formulating a cosmetic cream comprising: a non-oily base comprising greater than about 50% by volume, based upon the total volume of the formulation, of aloe vera extract; from about 0.1 to 1 .0% by volume of tocopheryl acetate as a source of Vitamin E; from about 0.1 to 0.5% by volume of retinyl palmitate as a source of Vitamin A; from about 0.05 to 0.5% by volume of ascorbyl palmitate as a source of Vitamin C; from about 0.1 . to 2.0% panthenol as a source of Vitamin B; from about 0.05 to 0.5% cholercalciferol as a source of Vitamin D; the balance being emulsifier, emollients and preservatives; applying the cosmetic cream to affected areas of the human epidermis; and wherein the non-oily base provides a mechanism for penetrating the human epidermis to a greater relative depth than oil-based cosmetic formulations.
1 2. The technique of claim 1 1 , wherein the cosmetic formulation consists essentially of: a non-oily base comprising approximately 60% by volume, based upon the total volume of the formulation, of aloe vera extract; from about 0.1 to 1 .0% by volume of tocopheryl acetate as a source of Vitamin E; from about 0.1 to 0.5% by volume of retinyl palmitate as a source of Vitamin A; from about 0.05 to 0.5 % by volume of ascorbyl palmitate as a source of
Vitamin C; from about 0.1 . to 2.0% panthenol as a source of Vitamin B; from about 0.05 to 0.5% cholercalciferol as a source of Vitamin D; the balance being emulsifier, emollients and preservatives.
PCT/US2003/030706 2003-02-06 2003-09-30 Cosmetic rejuvenating and healing product, method of its manufacture and uses thereof WO2004071500A1 (en)

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